# RGD-PIPELINE: ftp-file-extracts # MODULE: strains build 2022-07-07 # GENERATED-ON: 2023/05/20 # PURPOSE: information about active rat strains extracted from RGD database # CONTACT: rgd.data@mcw.edu # FORMAT: tab delimited text # NOTES: multiple values in a single column are separated by ';' # as of Oct 15, 2021, new columns were added: CITATION_ID, MRATBN_7.2_CHR, MRATBN_7.2_START_POS, MRATBN_7.2_STOP_POS, MRATBN_7.2_METHOD RGD_ID STRAIN_SYMBOL FULL_NAME ORIGIN SOURCE STRAIN_TYPE LAST_KNOWN_STATUS RESEARCH_USE ALLELES ALLELE_RGD_IDS RGSC_3.4_CHR RGSC_3.4_START_POS RGSC_3.4_STOP_POS RGSC_3.4_METHOD RNOR_5.0_CHR RNOR_5.0_START_POS RNOR_5.0_STOP_POS RNOR_5.0_METHOD RNOR_6.0_CHR RNOR_6.0_START_POS RNOR_6.0_STOP_POS RNOR_6.0_METHOD MRATBN_7.2_CHR MRATBN_7.2_START_POS MRATBN_7.2_STOP_POS MRATBN_7.2_METHOD CITATION_ID 10000 ACI/N A X C 9935, Irish Curtiss and Dunning 1926 at the Columbia University Institute for Cancer Research. To Heston 1945 at F30, to National Institutes of Health 1950 at F41. Subsequent sublines from Dunning or NIH. Donated to RRRC from NIH Animal Genetic Resource Bank (NIHAGR) Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery spontaneous tumors; chronic renal disease; congenital malformations Tnfrsf1a 621237 RRID:RRRC_00142 10001 AVN/Orl Ctr de Selection et d'Elev d'Anim de Lab, Orleans, France. inbred Unknown RRID:RGD_10001 10002 BBDP/Rhw S. Bieg and coworkers (1998) generated a congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 ± 53 days of age after the first and 67 ± 10 days of age after the 9th cycle. inbred Unknown RRID:RGD_10002 10003 BBDR/Rhw S. Bieg and coworkers (1998) generated a congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 +/- 53 days of age after the first and 67 +/- 10 days of age after the 9th cycle. R. H. William Laboratory, University of Washington, Seattle, Washington inbred Unknown RRID:RGD_10003 10004 BC/CpbU Obtained from the Central Laboratory Animal Institute of Utrecht University, The Netherlands. Central Laboratory Animal Institute of Utrecht University, The Netherlands. inbred Unknown RRID:RGD_10004 10005 BDIX/Han unknown unknown inbred Unknown RRID:RGD_10005 10006 BDVII/Cub Druckrey from F2 offspring of a cross between BDVI and BDI with subsequent selection of brother-sister pairs for a pink-eyed, yellow, blackhooded phenotype. Charles University, Department of Biology, Prague, inbred Unknown RRID:RGD_10006 10008 BN/SsNHsd Obtained by HSD from nucleus colony at NIH Harlan inbred Unknown RRID:RGD_10008 10009 BP/Cub Charles University, Department of Biology, Prague, inbred Unknown RRID:RGD_10009 10010 BUF/Pit Buffalo inbred Unknown RRID:RGD_10010 10011 COP/OlaHsd These are derived from the original colony which was developed by Dr. W.F. Dunning. Harlan inbred Unknown RRID:RGD_10011 10012 DA/PitN Unknown Unknown inbred Extinct RRID:RRRC_00154 10013 DON/Melb inbred Unknown RRID:RGD_10013 10014 F344/Pit inbred Unknown RRID:RGD_10014 10015 FHH/Eur An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria. The colony was transferred to Erasmus University. Erasmus University-Rotterdam inbred Unknown RRID:RGD_10015 10016 GH/Omr Genetically Hypertensive This colony was established from rats of Wistar origin. This is an hysterectomy-derived colony at the University of Otago, which was established from the Wellcome Institute colony at generation 79. These have been inbred for over 90 generations. University of Otago Wellcome Med. Res. Inst, New Zealand. inbred Unknown RRID:RGD_10016 10017 GK/KyoSwe Goto Kakizaki Developed from outbred Wistar rats with selection for high glucose levels in and oral glucose tolerance test (Goto et al 1975). Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden inbred Unknown RRID:RGD_10017 10018 IS/Kyo ishibashi rat Ishibashi rat is derived from a cross between a wild male and a Wistar female, with sib mating since 1975 at Azabu University, transferred to Kyoto University in 1978. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Osteosis RRID:RGD_10018 10019 LE/Mol Long Evans M & B A/S, Denmark. inbred Unknown RRID:RGD_10019 10020 LEW/Pit Lewis inbred Unknown RRID:RGD_10020 10021 LH/Mav In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed unrestrained conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. (see Vincent et al 1984, and Vincent and Sassard, 1994 for reviews). Laboratoire de Physiologie, 8 Avenue Rockfeller, 69373 Lyon Cedex 08, France inbred Unknown RRID:RGD_10021 10022 LN/Mav In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed unrestrained conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. (see Vincent et al 1984, and Vincent and Sassard, 1994 for reviews). Laboratoire de Physiologie, 8 Avenue Rockfeller, 69373 Lyon Cedex 08, France inbred Unknown RRID:RGD_10022 10023 LOU/CHan Louvain unknown unknown inbred Unknown RRID:RGD_10023 10024 M520/N To N 1951 from Heston at F51. Developed by Curtis at Columbia University Institute for Cancer Research, 1920; to Heston, 1949 at F49. NIH Animal Genetic Resource, Rat Resource and Research Center inbred Cryopreserved Embryo RRID:RRRC_00168 10025 MHS/Gib Milan Hypertensive Strain Outbred Wistar rats with brother x sister mating and selection for high systolic blood pressure Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy inbred Unknown RRID:RGD_10025 10026 MNR/N Maudsely non-reactive To N 1964 at F18+? from Maas. Developed by Broadhurst, 1954, from a commercial stock, with selection for low defecation response in an open field. A number of parallel sublines are in existence; these differ at least at the agouti and the major histocompatibility loci. NIH Animal Genetic Resource inbred Extinct RRID:RRRC_00174 10027 MNRA/N To Harrington in 1965 at F25 (Harrington 1981). NIH Animal Genetic Resource inbred Unknown RRID:RGD_10027 10028 MNS/Gib Milan Normotensive Strain Outbred Wistar rats with brother x sister mating and selection for low systolic blood pressure as a normotensive control for MHS. Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy inbred Unknown RRID:RGD_10028 10029 MR/Pit As for MNR except selection was for high defecation response in the open field. To Harrington in 1965 at F25 and to NIH in 1964 at F18+ (Hansen et al 1982). inbred Unknown RRID:RGD_10029 10030 NEDH/K Inbred by S. Warren at New England Deaconess Hospital, from Slonaker colony (University of Chicago ca. 1928). To Simonsen Laboratories in 1985 via B. Hoffman, Veterans Administration Medical Center, Palo Alto, CA. To Mollegaard in 1987. Central Institute for Diabetes, Karlsburg, Germany. inbred Unknown RRID:RGD_10030 10031 NP9 From Wistar inbred Unknown RRID:RGD_10031 10032 ODU/N Osaka Dental University From outbred Wistar Kyoto stock inbred by N Ito, Osaka Dental University. Selected for susceptibility to development of dental plaque (Ito et al 1975). To NIH in 1977 at F3 (Hansen et al 1982). NIH Animal Genetic Resource inbred Extinct RRID:RRRC_00176 10033 OKA/Wsl Professor Herve Bazin, Universite de Louvain, France inbred Unknown RRID:RGD_10033 10034 OM/Ztm Osborne-Mendel unknown unknown inbred Unknown RRID:RGD_10034 10035 P5C inbred Unknown RRID:RGD_10035 10036 PVG/Pit inbred Unknown RRID:RGD_10036 10037 SD/Rij From Sprague-Dawley stock of an unknown source to Hoechst, Frankfurt. To O. Haferkamp, University of Ulm, to ITRI-TNO Rijswijk, The Netherlands in 1972 (van Hooft 1990). Note that other sublines of "SD" rats (including SD/A, SD/Cpb, and SD/Waa) are known to differ among themselves, and from this strain (Bender et al 1984, Festing and Bender 1984). Harlan Rijswijk inbred Unknown RRID:RGD_10037 10038 SHR/OlaHsd Spontaneously Hypertensive Rat Harlan Sprague Dawley, Inc. inbred Unknown RRID:RGD_10038 10039 SHRSP/Riv Spontaneously Hypertensive Rat, Stroke Prone inbred Unknown RRID:RGD_10039 10040 SR/Jr Salt Resistant Originated from a Sprague-Dawley outbred colony developed by LK Dahl, Brookhaven National Laboratories, Upton, New York, selected for resistance to salt-induced hypertension (Dahl et al 1962a,b). Dr. John P. Rapp, Medical College of Ohio, USA, Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00056 10041 SS/Jr Salt Sensitive Strain originated from a colony of Sprague-Dawley outbred rats developed by LK Dahl, Brookhaven National Laboratories, Upton, New York, selected for sensitivity to salt-induced hypertension (Dahl et al 1962a,b, Rapp 1982) Dr. John P. Rapp, Medical College of Ohio, USA, Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm Hmox1 2806 RRID:RRRC_00055 10042 WAG/RijKyo Rij > Kyo (1979, F?, GF) National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Neurobiology RRID:RGD_10042 10043 WF/Pit Wistar Furth inbred Unknown RRID:RGD_10043 10044 WIST/Nhg Wistar From outbred Wistar stock in 1967. Gesellschaft f. Strahlen & Umweltforschung, Munich, Germany. inbred Unknown Ugt1a1|Abcd2 3935|69244 RRID:RGD_10044 10045 WN/N Inbred Wistar; W/N Heston in 1942 from Wistar stock of Nettleship, to National Institutes of Health in 1950 at F15. NIH Animal Genetic Resource inbred Unknown RRID:RGD_10045 10046 WKY/OlaHsd Harlan Sprague Dawley, Inc. inbred Unknown RRID:RGD_10046 10047 WTC/Kyo WTC was established as a coisogenic strain (tm<+/+>) from TRM (F18) in 1988. A missense mutation (c. 1061 C>T, p. A354V) in the hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene (Ohno et al. 2015). National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-01-03) RRID:RGD_10047 60984 GH University of Otago Medical School from rats of Wistar origin imported from England in 1930. Selection for high blood pressure started by Smirk in 1955. A number of sublines have been developed. Closely related to strain AS (Heslop and Phelan 1973). inbred Unknown RRID:RGD_60984 60985 BN BN Billingham and Silvers 1958, from a brown mutation maintained by DH King and P Aptekman in a pen-bred colony (Billingham and Silvers 1959). A plasma kininogen-deficient mutant strain (BN/Ka) has been described in which release of heat-induced substance P is defective (Tang et al, 1994) and response to the hypertensive effects of deoxycorticosterone acetate salt is much faster than in normal BN rats (Majima et al, 1995a,b). Charles River Laboratories inbred Unknown Cd36|Tnfrsf1a 2301|621237 RRID:RGD_60985 60986 BUF/N Heston 1946 from Buffalo stock of H. Morris. To NIH in 1950 at F10. NIH Autoimmune Rat Model Repository and Development Center inbred Extinct RRID:RGD_60986 60987 MHS/N Milan Hypertensive Strain Milan Hypertensive Strain: Outbred Wistar rats with brother x sister mating and selection for high systolic blood pressure (Bianchi et al 1974, Barber et al, 1994). Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy inbred Extinct Add1|Add2 2041|2042 RRID:RRRC_00169 60988 LOU/M Bazin and Beckers from rats of presumed Wistar origin kept at the Universite Catholique de Louvain. LOU/C was selected among 28 parallel sublines for its high incidence of plasmacytomas, and LOU/M for its low incidence. The two are histocomaptible. Histocompatible with LOU/C and maintained by selection of LOU/M males on the basis of acceptance of skin grafts from LOU/C rats (Bazin 1977, Beckers and Bazin 1978). inbred Unknown RRID:RGD_60988 60989 BP Strain selected for resistance to Walker 256 tumour. inbred Unknown RRID:RGD_60989 60990 LH/MavRrrc Lyon Hypertensive Lyon Hypertensive. In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed, unrestrained, conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. (see Vincent et al 1984, and Vincent and Sassard, 1994 for reviews). Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm (as of 2020-02-13) RRID:RRRC_00057 60991 LE Long Evans Dr. M. Sabourdy about 1960 from Long-Evans outbred stock. To Muhlbock, Amsterdam, and to Han in 1973. Note that other inbred strains independently derived from Long Evans stock may differ because of the outbred origin (Festing and Bender, 1984). inbred Unknown RRID:RGD_60991 60992 MNS Milan normotensive strain Outbred Wistar rats with brother x sister mating and selection for low systolic blood pressure as a normotensive control for MHS. (Bianchi et al 1974). Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy inbred Unknown RRID:RGD_60992 60993 FHH Fawn Hooded Hypertensive An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria. The colony was transferred to Erasmus University. University of Colorado Health Science Center, Denver, Colorado inbred Unknown RRID:RGD_60993 60994 F344 Fischer Curtiss and Dunning 1920 at Columbia University Institute for Cancer Research,To Heston 1949 (Billingham and Silvers 1959). To National Institutes of Health in 1951 (Hansen et al 1982). Subsequent sublines from Dunning or NIH. NIH Autoimmune Rat Model Repository and Development Center inbred Unknown RRID:RGD_60994 60995 DRY Recombinant inbred strain used as normotensive control in studies of hypertension. Sankyo Co., Ltd., Tokyo, Japan inbred Unknown RRID:RGD_60995 60996 DON Donryu rat R. Sato 1950 by inbreeding Japanese albino rats. xx inbred Unknown RRID:RGD_60996 60997 DA DA Developed from stock of unstated origin by Dr. T.T. Odell, Jr. at Oak Ridge National Laboratory, Tennessee to F11, then by Dr. Darcy Wilson at the Wistar Institute, who named it DA because it expressed the 'd' blood group allele of Joy Palm, and it is 'a' agouti in colour (Wilson 1965). Inbreeding was completed in about 1965. Although Palm and Black (1971) suggest it may be related to COP, there is no real evidence that this is the case. inbred Unknown Ednrb|Tnfrsf1a 2536|621237 RRID:RGD_60997 60998 COP This Copenhagen (COP) rat was an inbred strain from Curtiss 1921 at Columbia University Institute for Cancer Research. inbred Unknown RRID:RGD_60998 60999 LEW Lewis Dr. Margaret Lewis from Wistar stock, to Aptekman and Bogden 1954 at F20, to Silvers in 1958 at F31. Subsequently distributed by Silvers. Used as the inbred partner for a number of congenic strains at the major histocompatibility complex (Stark and Kren 1969). A substrain with congenital hydrocephalus due to primary aqueductal stenosis has been described by Yamada et al, (1992) Harlan Sprague Dawley Inc. Indianapolis, United States inbred Unknown Fgf2|Tnfrsf1a 2609|621237 RRID:RGD_60999 61000 SHR Spontaneously Hypertensive Rat Okamoto 1963 from outbred Wistar Kyoto rats. Bred from a male with mild hypertension, mated with a female with high blood pressure. Brother x sister mating with continued selection for high blood pressure (Okamoto 1969, Okamoto et al 1972). A number of sublines have been developed with a tendency to develop cardiovascular lesions and stroke (see particularly SHRSP) (Nagaoka et al 1976), and hypercholesterolemia (Yamori 1984). For a recent review see Yamori, (1994). However, there is no evidence for substrain differentiation among SHR stocks from the major commercial suppliers in the USA both respect to phenotype and DNA fingerprints (Blizard et al, 1991). Strain WKY, developed from the same base populations is sometimes used as a normotensive control, though its use as such must be questioned as it differs at many genetic marker loci (Festing and Bender 1984, and see also strain WKY). Stelzin et al (1992) found that SHR and WKY shared only 50% of their DNA fingerprint bands, whereas SS and SR shared about 80% of bands. Most authorities suggest that WKY alone is not a good control strain, and that for most comparative studies several normotensive strains should be used. There is an extensive literature on the characteristics of SHR. DeJong (1984) provides a useful comparative review of this and other hypertensive strains, and there are regular symposia on hypertensive rat strains (see J. Hypertension 4(suppl):S1-S541, 1986, and Jpn. Heart J. 28:567-648). inbred Unknown Agtr1b|Cd36|Ephx2 2071|2301|620732 RRID:RGD_61000 61001 NEDH Inbred by S. Warren at New England Deaconess Hospital, from Slonaker colony (University of Chicago ca. 1928). To Simonsen Laboratories in 1985 via B. Hoffman, Veterans Administration Medical Center, Palo Alto, CA. To Mollegaard in 1987. inbred Unknown RRID:RGD_61001 61002 BDIX Druckrey from a cross between BDI and BDVIII with subsequent selection of brother-sister pairs for agouti coat color and dark, pigmented eyes. NB. Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can _not_ be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable , and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain. inbred Unknown RRID:RGD_61002 61003 BC Hagadoorn, Holland to CPB in 1949 at F15. To Utrecht in 1973. inbred Unknown RRID:RGD_61003 61004 WIST/Zihk From Wistar outbred stock in 1978. inbred Unknown RRID:RGD_61004 61005 OM/N Osborne-Mendel Heston 1946 from non-inbred Osborne-Mendel stock obtained from J White, to NIH at F10 (Hansen et al 1982). NIH Autoimmune Rat Model Repository and Development Center inbred Extinct RRID:RGD_61005 61006 PVG PVG Kings College of Household Science, to Lister Institute, to Virol, to Glaxo 1946. Inbred by Glaxo. A substrain PVG/cBkl, which is C6 complement deficient due, presumably, to a spontaneous mutation has been described. In good environmental conditions it is perfectly healthy (Leenaerts et al, 1994). inbred Unknown RRID:RGD_61006 61007 WF Wistar Furth J Furth 1945 from a commercial Wistar stock in an attempt to develop a high leukaemia rat strain. Strain carries a distinctive heteropycnotic Y chromosome which may be used as a cellular marker (Zieverink and Moloney 1965). A substrain carrying the fuzzy mutation, which arose spontaneously in WF has been used in research on dermal toxicity, and is described in more detail by Marit et al, (1995). inbred Unknown RRID:RGD_61007 61008 WAG Wistar Albino Glaxo AL Bacharach, Glaxo Ltd 1924 from Wistar stock. Note that the presence of different coat color alleles in some sublines implies that this strain may have become genetically contaminated at some time in the past. It is therefore important that the subline should be stated carefully in published work. WAG/Cpb clearly differs from other sublines at many loci (Festing and Bender 1984). inbred Unknown RRID:RGD_61008 61009 AVN Unknown. Keil University from O Stark, Charles University, Prague. inbred Unknown RRID:RGD_61009 61010 SHRSP Spontaneously Hypertensive Rat, Stroke Prone The A1-sb and A3 substrains of SHR which had been bred as parallel lines from F20 to F36 were crossed (?) and further inbred with selection of offspring of parents that died of stroke (Okamoto et al 1974, 1986, Yamori 1984). To NIH in 1976, and designated SHRSP/A3N. Pathophysiology reviewed by Volpe and Rubattu (1994). Iffa Credo, L'arbresle, France, Max-Delbruck-Center for Molecular Medicine, Berlin-Buch inbred Unknown RRID:RGD_61010 61011 BB/N BioBreeding rat Mutation causing diabetes mellitus in a closed colony of outbred Wistar rats at Bio-Breeding Labs, Ontario, Canada in 1974 (Chappel and Chappel 1983). To Worcester in 1977 where inbreeding began. Sublines of diabetic-prone and diabetic-resistant animals have been developed, and there are also subline differences in the incidence, age of onset, untreated survival time of diabetes, leucopenia and body weight gain which can be attributed to genetic factors (Kloting et al 1987). A detailed study of 24 inbred and two outbred lines of diabetes-prone and diabetes resistant BB rats using eight marker loci found substantial genetic variation among and some variation within some of the colonies. The 22 colonies which were apparently isogenic could be divided into four groups on the basis of the marker loci (Prins et al 1990). Unavailable inbred Extinct RRID:RRRC_00144 61013 E3 Kroning, Gottingen from rats of unknown origin selected for fawn hooded phenotype, to Hannover 1957 at F16. To Gottschewski in 1964, then back to Hannover in 1968. inbred Unknown RRID:RGD_61013 61014 OLETF Otsuka Long-Evans Tokushima fatty Developed by Kazuya Kawano, Otsuka Pharmaceutical Co., Tokushima, Japan from Long-Evans outbred stock in 1982. A rat with spontaneous polyurea, polyphagia and polydipsia was found in a colony of outbred Long Evans rats purchased from Charles River in 1982. Selective breeding for diabetes with brother x sister mating was subsequently started at the Tokushima Research Institute, Otsuka Pharmaceutical Co., Japan to develop this strain Otsuka Long-Evans Tokushima fatty (OLETF). A deletion of 6847 bases in length in the Cckar gene of the OLETF was identified compared to the wild type gene of the LETO gene sequence' Otsuka Research Institute, Tokushima, Japan inbred Unknown RRID:RGD_61014 61015 LN/MavRrrc lyon normotensive (taken from Lyon Hypertensive entry, see LH) In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed unrestrained conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. (see Vincent et al 1984, and Vincent and Sassard, 1994 for reviews). Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00058 61096 SHR/NCruk Spontaneously Hypertensive Rat NIH derived strain maintained at the Charles River, United Kingdom. Charles River Laboratories UK inbred Unknown RRID:RGD_61096 61097 WKY/NCruk NIH derived strain maintained at the Charles River, United Kingdom. Charles River Laboratories UK inbred Unknown RRID:RGD_61097 61098 BXH/Ipcv These recombinant inbred strains are derived from the (BN-Lx/Cub, SHR/OlaIpcv x BN)F2 pairs and maintained at Czech Academy of Sciences, Prague, Czech Republic Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_61098 61099 HXB/Ipcv Derived from founder strains SHR/Ola and BN-Lx/Cub, this strain has been extensively genotyped in known genes as well as DNA markers, strain distribution patterns of 700+ alleles have been published. Institute of Physiology, Czech Academy of Sciences, Charles University, Prague recombinant_inbred Unknown RRID:RGD_61099 61100 SHR/Ola Strain originated from an inbred SHR strain from Harlan UK Ltd. Czech Academy of Sciences, Prague, Czech Republic inbred Unknown RRID:RGD_61100 61103 WKY This strain was maintained at Medical College of Ohio, Toledo, Ohio Medical College of Ohio, Toledo, Ohio inbred Unknown Cd36|Nos3 2301|3186 RRID:RGD_61103 61104 LEW/NCrl Substrain of LEW obtained from Charles River, which was developed from Dr Margaret Lewis from Wistar stock in early 1950s. This came to Charles River from Tulane in 1970 at F34. Charles River Laboratories USA inbred Unknown RRID:RGD_61104 61105 WKY/NHsd Derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland. and maintained at Harlan Indianapolis, Indiana U.S.A. EnvigoD8Mit5-D8Mgh6)/Ipcv A segment of chr. 8 is transferred from the normotensive BN-Lx/Cub rat to the SHR/Ola. Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic congenic Unknown 8 32203394 64762616 1 - by flanking markers 8 33603024 65467051 1 - by flanking markers 8 33558660 65717592 1 - by flanking markers 8 30848154 61290444 1 - by flanking markers RRID:RGD_61106 61107 BB/OK BioBreeding rat This colony was established in 1983, these rats were originally from an outbred colony from Ottawa, Canada. Central Institute for Diabetes, Karlsburg, Germany, National BioResource Project for the Rat in Japan inbred Cryopreserved Sperm Diabetes Obesity; Immunology Asns|Cav1|Cftr|Cyp51|Hgf|Met|Smo|Tac1|Stx1a|Cdk5 2162|2280|2332|2481|2794|3082|3726|3807|69430|70514 RRID:RGD_61107 61109 F344/NHsd F344/NHsd Strain originated from Curtiss and Dunning 1920 at Columbia University Institute for Cancer Research, To Heston 1949 (Billingham and Silvers 1959). To National Institutes of Health in 1951 (Hansen et al 1982). Subsequent sublines from Dunning or NIH. Envigo, Envigo aged inbred Unknown RRID:RGD_61109 61110 SHR/Mol Spontaneously hypertensive rat, maintained at the Mollegaard breeding center, displays traits of hypertension but not to diabetes. Mollegaard Breeding Centre Ltd., Denmark inbred Unknown RRID:RGD_61110 61111 DA/Slc dark agouti These were produced by from SD parents in 1984 by hysterectomy and fostering, then moved to Kumamoto University of Medicine in 1983. National BioResource Project for the Rat in Japan inbred Live Animals RRID:RGD_61111 61112 13M This is a Leprfa/Leprfa substrain derived from the Zucker rat. Laboratory of Human Behavior and Metabolism, Rockefeller University inbred Unknown RRID:RGD_61112 61113 BN-Lx These were derived by introgressing mutant Lx gene of the polydactylous rat onto the BN background. unknown mutant Unknown RRID:RGD_61113 61114 DA/Bkl Commercially available strain. Maintained at the National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, for production of DA background QTL monocongenic rats and experimental controls. Bantin and Kingman, Fremont, California inbred Unknown RRID:RGD_61114 61115 BN/SsN To N 1972 from Silvers at F34. Silvers began brother-sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King in a penbred colony. NIH Autoimmune Rat Model Repository and Development Center inbred Extinct RRID:RGD_61115 61116 SHRSP/A3 Derived from the a substrain of the SHR strain by selective inbreeding for stroke proneness. Graduate School of Human and Environmental Studies, University of Kyoto, Kyoto, Japan inbred Unknown RRID:RGD_61116 61117 BN-Lx/Cub Brown Norway with polydactyly-luxate These were derived by introgressing mutant Lx gene of the polydactylous (PD/Cub) rat onto the BN background. Charles University, Department of Biology, Prague inbred Unknown RRID:RGD_61117 61118 BUF/Mna Strain originated from Heston 1946 from Buffalo stock of H. Morris. To NIH in 1950 at F10. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Cancer; Urology Bsis 2221 RRID:RGD_61118 61119 WKY/NCrlCrlj Outbred Wistar stock from Kyoto School of Medicine to NIH in 1971, to Charles River in 1974. Charles River Laboratories Japan, National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo RRID:RGD_61119 61498 BN/NHsdMcwi Inbred from a single pair of SsN line rats obtained from Harlan Sprague Dawley (Alabama colony). Maintained at the Medical College of Wisconsin since 1995. To confirm homozygosity, the strain was tested with 200 microsatellite markers (genome-wide scan at 20cM) all of which were homozygous for all regions tested (Cowley et al. 2000, Physiol. Genomics. 2:107-115) PhysGen inbred Live Animals; Cryorecovery RRID:RGD_61498 61499 SS/JrHsdMcwi Inbred from a congenic control group of Dahl S rats (SS/Ren) obtained from Dr. Theodore Kurtz (UCSF, CA) which were originally derived from the Harlan SS/Jr colony. Maintained at the Medical College of Wisconsin since 1991, this strain has undergone considerable marker-selected breeding to eliminate residual heterozygosity and genetic contamination. To confirm homozygosity, the strain was tested with 200 microsatellite markers (genome-wide scan at 20cM) all of which were homozygous for all regions tested (Cowley etal. 2000, Physiol. Genomics. 2:107-115). PhysGen inbred Live Animals; Cryorecovery RRID:RGD_61499 61517 FHL/Eur Fawn Hooded Low blood pressure An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria. The colony was transferred to Erasmus University. FHL rats do not develop hypertension or renal damage Erasmus University-Rotterdam inbred Unknown RRID:RGD_61517 67934 WOKA Outbred Wistar BB rats from Biobreeding Laboratories, Ottawa, Canada in 1981 to Dr.I. Kloting, Dept. of Laboratory Animal Science, Inst. of Pathology, University of Greifswald,D-17495, Karlsburg, Germany. WOKA (originally designated WOK.1A) was developed by brother x sister mating from rats homozygous for RT1a, and WOKW (originally designatedWOK.1W) from rats homozygous for RT1U , a haplotype which pre-disposes to type I diabetes. inbred Unknown RRID:RGD_67934 67935 WOKW Outbred Wistar BB rats from Biobreeding Laboratories, Ottawa, Canada in 1981 to Dr.I. Kloting, Dept. of Laboratory Animal Science, Inst. of Pathology, University of Greifswald,D-17495, Karlsburg, Germany. WOKA (originally designated WOK.1A) was developed by brother x sister mating from rats homozygous for RT1a, and WOKW (originally designated WOK.1W) from rats homozygous for RT1U , a haplotype which pre-disposes to type I diabetes. Dept. of Laboratory Animal Science, Inst. of Pathology, University of Greifswald,D-17495, Karlsburg, Germany inbred Unknown RRID:RGD_67935 67936 WR Sykora, Rosice (Stark et al 1968b). No further infromation. inbred Unknown RRID:RGD_67936 67937 WST Strain WAG, Glaxo Research, Uxbridge, UK to Institute of Rheumatology, Warsaw in 1964. To Institute of Oncology, Warsaw 1964. To Institute of Occupational Medicine (Imp), Warsaw in 1965 (Pietrowicz 1986). inbred Unknown RRID:RGD_67937 67938 Y59 Strain developed in Zagreb, Jugoslavia. inbred Unknown RRID:RGD_67938 67939 YA/N No further information. Unavailable inbred Extinct RRID:RRRC_00191 67940 YO Fredrich Cancer Research Facility to Pit at F35. Genetic charactersitics given by Kunz et al (1987). Rapid elimination of Trichinella spiralis worms (2/12) (Bell, 1992) inbred Unknown RRID:RGD_67940 67941 Z61 Curtis 1920 at Columbia University Institute for Cancer Research. Susceptible to Cysticercus. Susceptible to oestrogen and 2-acetylaminofluorine-induced tumours. inbred Unknown RRID:RGD_67941 67942 ZI A breeder in W Germany to Hannover in 1980, to Kyoto in 1983. Carries recessive autosomal gene zitter which causes spongiform encephalopathy of the central nervous system with tremors at 15 days of age as well as curley whiskers and hair (Yamada et al 1989). inbred Unknown RRID:RGD_67942 67943 SHE/N-cp Reference found in: Berdanier C. D., Pan J. S., Hartle D. K., and Michaelis O. E. 1993, Comparative Biochemistry and physiology B-Biochemistry & Molecular Biology 106:87-94. unknown inbred Unknown RRID:RGD_67943 67945 IS from a cross between a wild male and a Wistar female, with sib mating since 1968. unknown inbred Unknown RRID:RGD_67945 67948 JC LEW/Ss to Hall Institute, to CSIRO in Brisbane, Australia. Presumed genetic comtamination some time prior to 1980, and re-named JC. To Dr. T Fukumoto, Hamamatsu University School of Medicine in 1983. Genetic markers described by Adams et al (1984). inbred Unknown RRID:RGD_67948 67957 APR Developed as strain MF by Holme and Piechuta (1979) by selective breeding of Sprague-Dawley outbred rats. Individuals were injected sub-cutaneously with egg albumin and B. pertussis vaccine i.p. then challenged with areosolised egg albumin after 14-18 days. Individuals within litters with the most severe symproms (longest duration of dyspnea) were selected and mated brother x sister. Later re-named APR (Apnea Prone Rat). inbred Unknown RRID:RGD_67957 67958 AS Albino Surgery University of Otago from Wistar rats imported from England in 1930. May be subline of GH, with which it is histocompatible (Heslop and Phelan 1973). National Institute for Medical Research, Mill Hill, UK inbred Unknown RRID:RGD_67958 67959 AS2 Outbred rats at the University of Otago Medical School, to Dept. of Surgery 1963 at F22-24. Not histocompatible with AS (Heslop 1968). inbred Unknown RRID:RGD_67959 67960 AUG Derived from one of the US August sublines in 1951 and distributed by the Chester Beatty Institute, Pollards Wood, England. inbred Unknown RRID:RGD_67960 67962 AN Outbred Wistar Imamichi strain. unknown inbred Unknown RRID:RGD_67962 67965 AXC A recombinant inbred of ACI and C. Curtiss and Dunning 1926 at the Columbia University Institute for Cancer Research. To Albert Segaloff of the Alton Ochsner Medical Foundation, New Orleans before 1956, to Southwestern Foundation for Biomedical Research in 1976. recombinant_inbred Unknown RRID:RGD_67965 67966 B Dr. P Swanson from Wistar stock now known to be King B strain, to Dempster at F43. To Harrington in 1971 at F85. inbred Unknown RRID:RGD_67966 67967 B/1N No further information. Unknown inbred Extinct RRID:RGD_67967 67971 BBZ Strain developed by crossing BB/Wor rats, a lean model of type I diabetes mellitus with a Zucker fatty (fa ) rat of unstated genetic background, followed by sib mating with forced heterozygosity for the fatty gene. Thus in each generation there is a ratio of 3 inbred Unknown RRID:RGD_67971 67974 BDE Zentralinstitut fur Versuchstierzucht, Hannover, from a cross between BDVII and E3, with selection for black hooded offspring. inbred Unknown RRID:RGD_67974 67975 BDI Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can _not_ be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable , and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain. inbred Unknown RRID:RGD_67975 67976 BDII Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can not be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable , and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain. inbred Unknown RRID:RGD_67976 67977 BDIII Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can _not_ be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable , and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain. inbred Unknown RRID:RGD_67977 67978 BDIV Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can _not_ be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable, and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain. inbred Unknown RRID:RGD_67978 67981 BDV Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can _not_ be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable , and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain. inbred Unknown RRID:RGD_67981 67983 BDVI Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can _not_ be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable , and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain. inbred Unknown RRID:RGD_67983 67984 BDVII Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can _not_ be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable , and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain. Low secondary antibody response to polypeptide (T,G)-Pro-Lys (20/20) (Gunther et al 1976) inbred Unknown RRID:RGD_67984 67986 BDVIII Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can _not_ be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable , and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain. inbred Unknown RRID:RGD_67986 67987 BDX Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can _not_ be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable , and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain. inbred Unknown Lypd3 69053 RRID:RGD_67987 67988 BEG from a cross between SC and TE. inbred Unknown RRID:RGD_67988 67989 BH D. Wilson, University of Pennsylvania from unknown stock. To Dml, who transferred stock to University of Iowa in 1973. Dml to Won to Ztm in 1973. inbred Unknown RRID:RGD_67989 67990 BI Formerly called B3, but now extinct. Slow elimination of \i Trichinella spiralis\i0 worms (11/12) (Bell, 1992) inbred Unknown RRID:RGD_67990 67991 BIL/1 University of Pittsburgh from a mutation in a colony of unknown background held by the NIH. NIH Autoimmune Rat Model Repository inbred Unknown RRID:RGD_67991 67993 BIL/2 University of Pittsburgh from a mutation in a colony of unknown background held by the NIH. NIH Autoimmune Rat Model Repository inbred Unknown RRID:RGD_67993 68000 BIRMB same as BIRMA. inbred Unknown RRID:RGD_68000 68001 BLK/N This strain has an agouti mutation Unknown inbred Extinct Asip 2003 RRID:RGD_68001 68007 BROFO Medical Biological Laboratory, Defence Research Organisation, The Netherlands. Large Wistar type of rat maintained in germ-free and SPF conditions. inbred Unknown RRID:RGD_68007 68008 BS University of Otago Medical School from a cross of wild rats x Wistar stock, with black phenotype backcrossed to the Wistar (Zeiss 1966). inbred Unknown RRID:RGD_68008 68011 C No further information. inbred Unknown RRID:RGD_68011 68012 CAP Polish Academy of Sciences, Krakow (Stark et al 1968a). inbred Unknown RRID:RGD_68012 68013 CAR/N Hunt-Hoppert caries resistant; CA/R Hunt 1937, developed for resistance to dental caries (Hunt et al 1955). NIH Autoimmune Rat Model Repository and Development Center inbred Unknown RRID:RGD_68013 68014 CAS Hunt 1937, developed for high incidence of dental caries. inbred Unknown RRID:RGD_68014 68015 CBH Woodruff, Edinburgh to Chester Beatty Inst., Fulham Road, to Chemical Defense Establishment, Porton in 1963. Then to Chester Beatty, Pollards Wood in 1966. To Olac in 1980 when the strain was re-named CBH (Chester Beatty Hooded). inbred Unknown RRID:RGD_68015 68018 CPB-WE Wistar outbred rats inbred at the Central Institute for Breeding of Laboratory Animals, Zeist, The Netherlands. inbred Unknown RRID:RGD_68018 68019 CRDH Cohen Rosenthal Diabetic Hypertensive As Cohen Rosenthal Diabetic Hypertensive, from a cross between strains CDR and SHR followed by selection for high blood pressure and blood glucose levels following two-months of feeding a copper-poor, high (74%) sucrose diet. Selected animals were brother x sister mated (Cohen et al, 1993, Rosenthal et al 1995). Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel inbred Unknown RRID:RGD_68019 68020 CWS R Shoji from a cross of an outbred Jcl:SD rat with spontaneous cataract and WKAH inbred rats. Subsequent brother x sister mating with selecting for cataract resulted in all offspring from the 3rd. generation developing cataract accompanied by microphthalmia which can be observed from the day that the eyes open. inbred Unknown RRID:RGD_68020 68022 DB No further information. inbred Unknown RRID:RGD_68022 68023 DEBR Dundee experimental bald rat The DEBR rats have been bred at the University of Dundee since March 1984. The original crosses involved the inbred stock BDIX rats showing lesion and Wistar rat. The descendants of this cross resulted from full sib-matings.Two strains of DEBR rats are geing developed: the black-hooded and brown-hooded strains. inbred Unknown RRID:RGD_68023 68026 DSS/1N Three inbred strains developed from outbred Sprague-Dawley stock selected for sensitivity to sodium chloride-induced hypertension (Dahl et al. 1962a, b). Inbred by Iwai and then Hansen (N). Unknown inbred Extinct RRID:RRRC_00155 68027 DSS/2N Three inbred strains developed from outbred Sprague-Dawley stock selected for sensitivity to sodium chloride-induced hypertension (Dahl et el 1962a, b). Inbred by Iwai and then Hansen (N). Unknown inbred Extinct RRID:RRRC_00156 68028 DSS/3N Three inbred strains developed from outbred Sprague-Dawley stock selected for sensitivity to sodium chloride-induced hypertension (Dahl et el 1962a, b). Inbred by Iwai and then Hansen (N). Unknown inbred Extinct RRID:RRRC_00157 68029 DXE-1 Set of 4 recombinant inbred strains from a cross between DA and E3 (Central Institute, Hannover) recombinant_inbred Unknown RRID:RGD_68029 68031 ET WKA strain obtained from Taisho Pharmaceutical Co. Ltd. Develops ectopic scrota in about 70% of males. The defect is controled by multiple genes, and the females are normal (Ikadai et al 1988b). Taisho Pharmaceutical Co. Ltd inbred Unknown RRID:RGD_68031 68032 EXBH Hannover as a recombinant inbred strain from a cross between E3 and BN. Developed as a coat colour testing stock. Low reproductive performance (Greenhouse et al 1990) inbred Unknown RRID:RGD_68032 68034 F6R Mutation in an irradiated F344 strain obtained from the National Institute of Genetics, Misima, Japan. Carries chromosomal translocation (9:14) (Yosida et al 1985). inbred Unknown RRID:RGD_68034 68035 FCH Fice Combined Hyperlipidemic strain. Strain developed from outbred stock by selection for high serum cholesterol. inbred Unknown RRID:RGD_68035 68036 FH Dodds, 1974 from an outbred stock developed by NRF Maier, University of Michigan, Ann Arbor, from a cross between German brown rats and white Lashley rats (Tschopp and Zucker 1972). Note that other inbred strains have been developed from the same outbred stock (see strains FHH and FHL), which may have different characteristics. inbred Unknown Rab38ru 1600311 RRID:RGD_68036 68038 FHL see FHH. inbred Unknown RRID:RGD_68038 68040 FNL Fice Normolipidemic strain. Developed as a control strain for FCH (see FCH). inbred Unknown RRID:RGD_68040 68041 G Gorter, Holland to Hagedoorn, to CPB at F 35 (van Vliet 1977) inbred Unknown RRID:RGD_68041 68042 GEPR Jobe, 1971 from outbred Sprague-Dawley stock. Selected for moderate susceptibility to audiogenic stimuli-induced seizures (Reigel et al 1986a). inbred Unknown RRID:RGD_68042 68044 GHA The Queen Elizabeth Hospital, Woodville, S. Australia from mixed Wistar, LEW and coloured stock (Festing and Staats 1973). inbred Unknown RRID:RGD_68044 68046 HCS Harvard to Liverpool, UK in 1960. inbred Unknown RRID:RGD_68046 68047 HMT Outbred Alderley Park (strain 1) inbred since 1964 as "Harwell Mouth Tumor". inbred Unknown RRID:RGD_68047 68048 HS Probably from same Wistar x wild rat cross as BS (Zeiss 1966). Docile, fair reproduction. Approximately 12% hydrocephalus. inbred Unknown RRID:RGD_68048 68049 HXB-1-43/Ipcv Set of 17 recombinant inbred strains developed by Pravenec, Klir and Kren from a cross between SHR/OlaIpcv and BN.Lx/CubIpcv, and described by Pravenec et al (1988). Strains have now been typed at 500 loci and scanned for quantitative trait loci associated with blood pressure and heart weight (Pravenec et al, 1995). These recombinant inbred strains are derived from the (SHR/OlaIpcvx BN-Lx/Cub)F2 pairs. Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.166 NL-3508 TD Utrecht, Netherlands recombinant_inbred Unknown RRID:RGD_68049 68050 IIM Set of nine strains bred as parallel strains from a single outbred colony maintained by B. Houssay in 1948. All strains were selected for large body weight and high fertility. One strain designated Beta IIM (RGD:40924649) derived from line 'b' became obese with mild glucose intolerance and glycosurea in older obese rats (Calderari et al 1987). Alpha IIM (RGD:40924650) was used as a control strain in study. inbred Unknown RRID:RGD_68050 68051 INR/N Harrington 1962 from a stock selected by CS Hall for low open field defaecation. Unknown inbred Extinct RRID:RRRC_00160 68052 IR Harrington 1962 from a cross of a Michigan and a Berlin stock (Harrington 1981). inbred Unknown RRID:RGD_68052 68057 K Dr. E. Matthies, Halle-Wittenberg 1958 from outbred Wistar stock.. Low spontaneous tumour incidence (less that 0.5%). Good breeding performance. Weight at 100 days 290g in males and 200g in females. Developed for resistance to a range of transplantable tumours (Matthies and Ponsold 1973). inbred Unknown RRID:RGD_68057 68058 KGH/PitN Kunz and Gill from outbred NEDH rats supplied by the Animal Research Center, Harvard University (Kunz and Gill 1974, Kunz et al 1974). Unknown inbred Extinct RRID:RRRC_00162 68059 KIRBY-B From a cross between black hooded and CFY outbred rats with selection for resistance to chronic respiratory disease. Litter size 8-12 (60% male), but only 4-5 weaned. Agile, but tame (Bertok 1980). inbred Unknown RRID:RGD_68059 68060 KX developed from Slonaker colony, University of Chicago about 1928. Sublines which carry gene \i ic\i0 (infantile ichthyosis) and colour genes C and H have also been developed (Knox 1977) inbred Unknown RRID:RGD_68060 68061 KYN/Hok Makino, Hokkaido University 1960 from stock the carrying the National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_68061 68062 LA/N from a cross between ALB/N and a hooded stock of unknown origin (Hansen et al 1982). NIH Autoimmune Rat Model Repository and Development Center inbred Extinct RRID:RGD_68062 68063 LA/N-cp The corpulent (LA/N-cp) ratdeveloped at the National Institutes of Health (NIH) is a congenic strain initially derived by mating a male Koletsky rat that was heterozygous for the corpulent gene (cp/ +) to a female Lister Albany/NIH (LAIN) rat. The obese homozygous (cp/cp) littermates developspontaneous insulin resistance, obesity, impaired glucose tolerance, hypertriglyceridemia and atherosclerosis. NIH Autoimmune Rat Model Repository and Development Center congenic Unknown RRID:RGD_68063 68065 LEA Hok from outbred Long Evans stock, selected for agouti coat colour (though Long Evans stock is usually fixed for non-agouti, hooded genes) (MC Yoshida, personal communication). Liver gangliosides are of the a-type (cf ACI,LEW & BUF) (Kasai et al 1993) inbred Unknown RRID:RGD_68065 68066 LEC In 1975, at the Center for Experimental Plants and Animals, Hokkaido University, Long Evans Cinnamon was derived originally from a closed colony of Long-Evans rats obtained from Kobe University in 1975. inbred Unknown RRID:RGD_68066 68067 LEJ/Hok Hok 1956 from Pacific Farms, USA as an outbred stock (Sasaki, personal communication). National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_68067 68068 LEM Subline of LET, which was a cross between LEW and a Long-Evans stock developed by TH Yoshida. Carries an inversion of chromosome 1 (Yosida, 1980). inbred Unknown Ckb 2357 RRID:RGD_68068 68069 LEO from National Institute of Genetics Misima, Japan. Control strain for LEM and LET, without chromosomal inversions (Yosida, 1980). inbred Unknown RRID:RGD_68069 68070 LEP Charles University from cross of outbred animals, including a Long Evans stock (Brdicka, personal communication). Has an unusual esterase haplotype (Festing and Bender 1984) inbred Unknown RRID:RGD_68070 68071 LER/N Originally designated Le-R and thought to be a mutation within LEW conferring resistance of experimental allergic encephalomyelitis (EAE) (Waxman et al, 1981, Driscoll et al 1985, Gasser et al, 1983). However, it now appears to have been an accidental genetic contamination by BUF/N rats (Goldmuntz et al, 1993),. See LEW, Immunology. Unavailable inbred Extinct RRID:RRRC_00164 68072 LET from National Institute of Genetics, Misima, Japan. From a cross betrween LEW and LEJ. Homozygous for a 1 inbred Unknown RRID:RGD_68072 68073 LETL A rat with spontaneous polyurea, polyphagia and polydipsia was found in a colony of outbred Long Evans rats purchased from Charles River in 1982. Selective breeding for diabetes with brother x sister mating was subsequently started at the Tokushima Research Institute, Otsuka Pharmaceutical Co., Japan inbred Unknown RRID:RGD_68073 68074 LETO THe LETO was obtained by mating of Long-Evan rats in Otsuka Pharmaceutical Co.The LETO has not shown the diabetic syndrome. inbred Unknown RRID:RGD_68074 68077 LL/MavRrrc Lyon hypotensive Lyon Low-Tensive. See LH Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00059 68079 LOU Bazin and Beckers from rats of presumed Wistar origin kept at the Universite Catholique de Louvain. LOU/C was selected among 28 parallel sublines for its high incidence of plasmacytomas, and LOU/M for its low incidence. The two are histocomaptible (Bazin 1977, Bazin and Beckers 1978). Institut National de la Sante' et de la Recherche Medicale, Bichat-Claude Bernard, Paris, France inbred Unknown RRID:RGD_68079 68082 LUDW Ludwig Wistar; Wistar stock to Ludwig Institute to Olac in 1979. Susceptible to tumour induction by MNU. inbred Unknown RRID:RGD_68082 68083 LXB Set of 13 recombinant inbred strains from a cross between LEW and BN (Central Institute, Hannover) recombinant_inbred Unknown RRID:RGD_68083 68084 M14 AB Chapman 1940 from Sprague-Dawley stock, with selection for low ovarian response to pregnant mare's serum. inbred Unknown RRID:RGD_68084 68085 M17 AB Chapman 1940 from Sprague-Dawley stock with selection for high ovarian response to pregnant mare's serum. inbred Unknown RRID:RGD_68085 68086 M520 Curtiss 1920, Columbia University Institute for Cancer Research, to Heston in 1949 at F49. To NIH in 1951 at F51 (Hansen et al 1982). A congenic strain lacking vasopressin due to the presence of the diabetes insipidus gene, di (from the Brattleboro rat) has been described (Colombo et al, 1992). inbred Unknown RRID:RGD_68086 68087 MAXX From a cross of BNxLEW with subsequent inbreeding. inbred Unknown RRID:RGD_68087 68088 MF Developed as strain MF by Holme and Piechuta (1979) by selective breeding of Sprague-Dawley outbred rats. Individuals were injected sub-cutaneously with egg albumin and B. pertussis vaccine i.p. then challenged with areosolised egg albumin after 14-18 days. Individuals within litters with the most severe symproms (longest duration of dyspnea) were selected and mated brother x sister. Later re-named APR (Apnea Prone Rat). inbred Unknown RRID:RGD_68088 68091 MLCS Milan low-calpastatin strain From a cross between MHS and MNS followed by backcrossing to MNS with selection for low calpastatin activity. Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy recombinant_inbred Unknown RRID:RGD_68091 68097 MSUBL Dr. Stroyeva, Institute of Developmental Biology, Moscow from a cross of wild rats x MSU microphthalmic rats obtained from Dr Brouman, Montana State University. Selected for high incidence of microphthalmia (Borodin 1977). inbred Unknown RRID:RGD_68097 68098 MW Munich Wistar Munich Wistar stock selected for superficial glomeruli and inbred by Harlan-Sprague-Dawley, now at F17 (1990). See also MWF and WMS. unknown inbred Unknown RRID:RGD_68098 68099 MWF From outbred Wistar rats selected for large numbers of superficial glomeruli. inbred Unknown RRID:RGD_68099 68100 NBL Bogden in the mid-1970s from Noble (Nb) strain rats (brother x sister mated but not descended from a single pair, and therefore not necessarily isogenic). To Fredrich Cancer Research facility in 1978. Note that the strain name NBL was selected in 1989. In the literature these rats are called Noble or Nb rats, usually without identifying whether the animals came from the non-isogenic colony of Dr. Noble or from the isogenic colony at the National Cancer Institute (Greenhouse et al 1990). inbred Unknown RRID:RGD_68100 68103 NER noda epileptic rat From Crj: Wistar rats purchased from Charles River Japan in July 1985. Developed by A. Noda, Tokyo University of Agriculture, Hokkaido, from a cross of mutant rats with spontaneous tonic-clonic seizures (Noda et al. 1998). Susceptible to seizures induced by pentylenetetrazol, tossing and transcorneal electric shock, but not tactile, photic or acoustic stimuli or transauricular electric shock. No pathologic changes have been found in the CNS. The condition appears to be inherited as an autosomal recessive gene and is comparable to generalised tonic-clonic seizures in humans. Maintained by Has. inbred Unknown RRID:RGD_68103 68104 NIG-III/Hok From a mating in 1956 between a wild rat trapped in Misima, Japan, and Castle's black rat. To Hokkaido in 1975. Work on characterisation of RT1 summarised by Natori (1987). National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_68104 68106 NSD/N NIH, Bethesda, 1964 from a non-inbred (Sprague-Dawley) stock. NIH Autoimmune Rat Model Repository and Development Center inbred Extinct RRID:RGD_68106 68107 NZR Subline of AS2 separated at F32. inbred Unknown RRID:RGD_68107 68109 ODUS As for ODU, but maintained at Osaka Dental University. inbred Unknown RRID:RGD_68109 68113 OXYR/Nov Developed in 1972 at the Institute of Cytology and Genetics, Russian Academy of Sciences (Novosibirsk) by Professor R.I. Salganik from Wistar stock, in contrast to OXYS rat strain by selection for resistance to cataractogenic effect of galactose rich diet and brother-sister mating of highly resistant rats. In 1992, due to new findings, the symbol R was assigned to this strain. Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia inbred Unknown RRID:RGD_68113 68114 OXYS/Nov Developed in 1972 at the Institute of Cytology and Genetics, Russian Academy of Sciences (Novosibirsk) by Professor R.I. Salganik from Wistar stock by selection for susceptibility to cataractogenic effect of galactose-rich diet and brother-sister mating of highly susceptible rats. Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia inbred Unknown RRID:RGD_68114 68115 P77PMC Wistar rats from Beijing Medical College in 1977. inbred Unknown RRID:RGD_68115 68116 PA King 1909 from Wistar Institute stock, to Aptekman in 1946 at F135, to Bogden 1958 at F155. The oldest inbred strain of rats. WKA is probably a parallel subline of this strain. Vigorous (and vicious), healthy, good reproduction. inbred Unknown RRID:RGD_68116 68117 PETH/N Royal College of Surgeons, RCS Bourne 1938, to Sidman at F9N1, to NIH in 1966 at F9N1F18. Should probably be regarded as a subline of RCS. NIH Autoimmune Rat Model Repository and Development Center inbred Unknown RRID:RGD_68117 68118 PKD PKD Outbred Han:SPRD-cy/+ Sprague-Dawley rats from the Zentralinstitut furVersuchstierkunde, Hannover, Germany to Dr. Bettina Kranzlin, Mannheim, Germany. Brother xsister inbreeding started in 1991. Central Institute for Laboratory Animal Breeding, Hanover, Germany inbred Unknown RRID:RGD_68118 68119 PSDO/N Reserved symbol for strain in development now at F6 (NIH 1989). Unavailable inbred Extinct RRID:RRRC_00178 68121 R Muhlbock from a Wistar stock in 1947. A congenic strain with hyperbilirubinaemia and jaundice has been developed by Leyten et al (1986) by backcrossing the jaundice gene j (the Gunn rat) onto strain R. inbred Unknown RRID:RGD_68121 68122 RCS/N Developed before 1965 by Sidman from stock obtained from Sorsby of the Royal College of Surgeons, London (Sidman and Pearlstein 1965). PETH is a presumed subline. Unavailable inbred Extinct RRID:RRRC_00180 68123 RHA/N Roman high avoidance Bignami selected for high avoidance conditioning with light as a conditioned stimulus and electric shock as the unconditioned stimulus (Bignami 1965). To NIH in 1968 where b x s mating was initiated. NIH Autoimmune Rat Model Repository and Development Center inbred Extinct RRID:RGD_68123 68124 RII/1 Tif from outbred Sprague-Dawley stock received from Ivanovas, Germany (Greenhouse et al 1991). inbred Unknown RRID:RGD_68124 68125 RII/2 From outbred Sprague-Dawley stock received from IFFA Credo, France has been brother x sister mated for 16 generations (Greenhouse et al 1991). inbred Unknown RRID:RGD_68125 68126 RLA/N Bignami selected for high avoidance conditioning with light as a conditioned stimulus and electric shock as an unconditioned stimulus (Bignami 1965). This outbred stock to NIH in 1968 where brother x sister mating was initiated. See also RHA. Note that the original outbred stock and other independently-derived inbred strains may differ in characteristics. Behavioural characteristics described by Driscoll et al (1979) and Fumm and Battig (1979). See RHA for details of comparative studies involving both strains. inbred Unknown RRID:RGD_68126 68127 RP/AEurRij Muhlbock, Amsterdam, 1947, from Wistar stock. To University of Leiden in 1958. To Erasmus University, Rotterdam in 1968. To Rijswick in 1982 (Greenhouse et al 1991). inbred Unknown RRID:RGD_68127 68128 S5B Poiley 1955 from a cross of outbred NBR rats x Sprague-Dawley, with five generations of backcrossing of the albino gene followed by sib mating. inbred Unknown RRID:RGD_68128 68129 SBH Sabra hypertensive Sabra Hypertensive Hebrew University Sabra outbred rats with brother x sister mating and selection for high blood pressure following unilateral nephrectomy and treatment with deoxycorticosterone and sodium chloride (Ben-Ishay et al 1981, Ben-Ishay 1984, Ben-Ishay and Yagli, 1994 who also reviews their characteristics). Barzilai Medical Center, Ashkelon, Israel inbred Unknown RRID:RGD_68129 68130 SBN As for SBH, but selected for low blood pressure as a normotensive control strain for SBH. See SBH (Ben-Ishay 1984). inbred Unknown RRID:RGD_68130 68131 SC Outbred Wistar Imamichi. Has small eyes and cataract (Proc. 8th. ICLAS Symposium, Gustav Fischer Verlag pp353-360) inbred Unknown RRID:RGD_68131 68133 SDJ/Hok Takeda Chemical Industries from Sprague-Dawley stock, to Hokkaido in 1966. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Slc2a2 3705 RRID:RGD_68133 68134 SDNK Sprague-Dawley outbred rats inbred since 1967 by Dr. K Yasutomi, Nippon Inst. for Biological Sciences, Japan. inbred Unknown RRID:RGD_68134 68136 SEL Dunning 1948. Probably extinct. inbred Unknown RRID:RGD_68136 68137 SHHF JE Miller of GD Searle to Sylvia McCune in 1983. Corpulent gene (cp ) partially backcrossed to SHR/N, followed by brother x sister mating (with some exceptions). Originally designated SHR/N-cp, but re-named to avoid confusion with the strain described by Michaelis and Hansen (1990) which has been backcrossed to N14. Strain is maintained by matings of proven cp/+ heterozygotes, and in some cases cp/cp homozygous males have proved to be fertile. inbred Unknown Grk2|Grk3 2062|2063 RRID:RGD_68137 68140 SPRD/Hsd Originated by the Sprague-Dawley Company, Madison, Wisconsin, in 1925 through a series of crosses begun with a single-hooded male and six albino females of unknown origin. Current Harlan colonies are direct descendants of this original colony. Harlan outbred Unknown RRID:RGD_68140 68143 TA Outbred Wistar Imamichi. inbred Unknown RRID:RGD_68143 68144 TE Outbred Wistar Imamichi rats. Males develop hydro-testes caused by sperm retention cysts in the efferent duct. This defect is caused by an autosomal dominant locus and two autosomal recessive loci. Females are normal (Ikadai et al 1987). inbred Unknown RRID:RGD_68144 68145 TF From outbred Wistar Imamichi rats. Carries an autosomal recessive gene causing male pseudohermaphroditism due to defect of Leydig cells. Homozygous females are normal (Ikadai et al 1988). inbred Unknown RRID:RGD_68145 68146 THA Developed from Jcl-Wistar stock by inbreeding with selection for a high rate of electric shock avoidance by lever pressing. The strain has good learning performance not only in the Sidman avoidance task, but also in two other tasks when compared with the Jcl-Wistar stock, though the sensitivity of the strain to electric shocks or heat stress was less (Shigeta et al 1990). inbred Unknown RRID:RGD_68146 68147 THE/Utp Tsukuba high-emotional rat Wistar albino rats selected for low ambulation in a bright runway out of a dark starting box (high emotionality) (see also TLE). National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Behavior RRID:RGD_68147 68148 TLE/Utp Tsukuba low-emotional rat Wistar albino rats selected for high ambulation in a bright runway out of a dark starting box (low emotionality) (see also THE). National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo Behavior RRID:RGD_68148 68149 TM Tester Moriyama rat Shionogi Pharmaceutical Company to Kyoto in 1976. Has thrombocyte storage pool deficiency (J Yamada, personal communication). Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Kyoto, Japan inbred Unknown RRID:RGD_68149 68150 TMB PL Broadhurst from stock selected by Tryon for good maze learning performance. Although TMB and TS1 are derived from the same outbred stock, they were inbred independently and should be regarded as different inbred strains (Festing 1979b). inbred Unknown RRID:RGD_68150 68151 TMD PL Broadhurst from stock selected by Tryon for poor maze learning performance. Although TMD and TS3 are derived from the same outbred stock, they were inbred independently and should be regarded as different inbred strains (Festing 1979b). inbred Unknown RRID:RGD_68151 68152 TO/Hok Tokyo rat A breeder in Tokyo, Japan, to Hokkaido University in 1952 (Festing and Staats 1973). Resistant to the induction of EAU by interphotoreceptor retinol-binding protein (contrast WKAH, W/M, LEJ, LEW and BUF) (Sasamoto et al, 1994). National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_68152 68154 TOM Toma Institute, Japan (Ikadai, personal communication, 1991) inbred Unknown RRID:RGD_68154 68155 TS WKA strain obtained from Taisho Pharmaceutical Co. Ltd. Develops ectopic scrota in about 70% of males. The defect is controled by multiple genes, and the females are normal (Ikadai et al 1988b). inbred Unknown RRID:RGD_68155 68156 TS1 Harrington, from stock selected by Tryon in 1929 for good maze learning performance (Harrington 1981). Although TMB and TS1 are derived from the same outbred stock, they were inbred independently and should be regarded as different inbred strains (Festing 1979b). inbred Unknown RRID:RGD_68156 68157 TS3/N Harrington, from stock selected by Tryon for poor maze learning performance (Harrington 1981). Although TMD and TS3 are derived from the same outbred stock, they were inbred independently and should be regarded as different inbred strains (Festing 1979b). Unavailable inbred Extinct RRID:RRRC_00185 68158 TT outbred Wistar Imamichi strain. Carries an autosomal recessive gene \i as\i0 causing an arrest of spermatogenesis at an early meiotic stage. Homozygous females have normal fertility (Ikadai, personal communication, 1991). inbred Unknown RRID:RGD_68158 68160 TU From a cross of a wild male and Wistar Imamichi outbred rats. Small litter size with malformations of kidneys and vas deferens in about 20% of offspring (H Ikadai, personal communication, 1991) inbred Unknown RRID:RGD_68160 68161 TW Wistar Imamichi outbred stock. Testicular hypoplasia (unilateral or bilateral) with aplasia of the epididymus and ductus deferens in about 50% of males. Female genital organs are normal (Ikadai et al 1985, Ajisawa et al 1985). inbred Unknown RRID:RGD_68161 68162 TX From a cross between a wild male and Wistar Imamichi females (H Ikadai, personal communication, 1991) inbred Unknown RRID:RGD_68162 68163 U Zootechnical Institute, Utrecht to the Netherlands Cancer Institute in 1958. To Erasmus University, Rotterdam, then to ITRI-TNO, Rijswijk, the Netherlands in 1960 (van Hooft 1990). inbred Unknown RRID:RGD_68163 68164 UChA Wistar rats selected for low voluntary 10% ethanol consumption, with brother x sister mating. Initiated from ALKO Labs, Finland now established in 1947 at University of Chile. University of Chile, Casilla, Chile inbred Unknown RRID:RGD_68164 68165 UChB Wistar rats selected for high voluntary 10% ethanol consumption, with brother x sister mating. Initiated from ALKO Labs, Finland now established in 1947 at University of Chile. University of Chile, Casilla, Chile inbred Unknown RRID:RGD_68165 68166 W/Hok Wistar Institute to University of Tokyo, Japan in 1938. To Hokkaido in 1944. Inbred by Makino. Congenital cleft palate 0.5% (Shoji 1977). inbred Unknown RRID:RGD_68166 68167 W/Nhg Wistar rats from the Zentralinstitut fur Versuchstier, Hannover in 1964, inbred since 1973 in Neuherberg, Germany. inbred Unknown RRID:RGD_68167 68168 WA St Thomas's Hospital, from outbred Wistar stock, to Laboratory Animals Centre in 1964 at F43 (Festing and Blackmore 1971). To Ola in 1983. inbred Unknown RRID:RGD_68168 68169 WAB Boots Ltd., from same stock as WAG, but separated in 1926, prior to inbreeding. Benign thymoma in 23% of individuals over 2 years, with 50% incidence in castrated males and 57% in spayed females (Hinsull and Bellamy 1977). inbred Unknown RRID:RGD_68169 68171 WBB/1N No further information Unavailable inbred Extinct RRID:RRRC_00186 68172 WBB/2N No further information. Unavailable inbred Extinct RRID:RRRC_00187 68173 WBN Wistar rats from the Institute of Experimental Gerontology, Basel brother x sister mated in the Institute of Pathology, University of Bonn since 1961. To the Instuitute of Medical Science, University of Tokyo in 1976, then to Shizuoka Laboratory Animals Center where they were hysterectomy-derived. inbred Unknown RRID:RGD_68173 68174 WCF R Shoji, 1972 from a male rat of strain WKAH/Idr with clubfoot of the right hind foot. inbred Unknown RRID:RGD_68174 68175 WDF Ikeda et al (1981) by backcrossing the fatty gene to F8 and later generations of outbred Wistar Kyoto rats being inbred by brother x sister mating. The aim was to develop a model of non-insulin-dependent diabetes mellitus. inbred Unknown RRID:RGD_68175 68176 WEC Centraal Proefdierenbedrig TNO from an outcross involving strains B, WAG and others, followed by inbreeding (Festing 1979b). Formarly known as WE/Cpb. Hyporesponder to dietary cholesterol (van Zutphen, unpublished). inbred Unknown RRID:RGD_68176 68177 WEK Centraal Proefdierenbedrig TNO 1958 to Utrecht in 1973. Formerly known as WEchoc. Hyporesponder to dietary cholesterol (van Zutphen, unpublished). inbred Unknown RRID:RGD_68177 68178 WELS Outbred wistar rats in 1976. Some biological details mainly on haematology and blood biochemistry given by Henize et al (1984) inbred Unknown RRID:RGD_68178 68180 WIN WI outbred rats inbred since 1980 as WIN (Wistar-Imamichi-Natori). Has a unique RT1.A haplotype (RT1.A s BlDl) (Natori et al 1986). inbred Unknown RRID:RGD_68180 68183 WKA King 1909 from Wistar Institute stock to Aptekman in 1946 at F135, to Hokkaido University in 1953 at F148. To Pit at F205 (Kunz et al 1987). Probably genetically identical to PA. Slow elimination of Trichinella spiralis worms (12/12) (Bell, 1992) inbred Unknown RRID:RGD_68183 68184 WKAH/Hok Wistar-King Aptekman Hokkaido King 1909 from Wistar Institute stock to Aptekman in 1946 at F135, to Hokkaido University in 1953 at F148. Formerly called WKA, Probably gentically identical to PA. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo RRID:RGD_68184 68185 WKAM King 1909 to Aptekman 1946 at F135 to Hok in 1953 at F148 to Ms in 1953 (precise number not known), to Jic in 1980 at F208, back to Ms in 1980 at F211, to Slc in 1986 at F228, back to Ms in 1987 at F230 (Greenhouse et al 1990). Formerly called WKA. inbred Unknown RRID:RGD_68185 68186 WKHA/N From a cross between SHR and WKY with selection for high spontaneous activity and low systolic blood pressure. Unavailable inbred Extinct RRID:RRRC_00188 68187 WKHT/N From a cross between SHR and WKY, with selection for high blood pressureand low spontaneous activity (Hendley et al 1988, Knardahl and Hendley 1990, Hendley and Fan, 1992). Unavailable inbred Extinct RRID:RRRC_00189 68188 WKS National Institute of Genetics, Mishima, Japan. inbred Unknown RRID:RGD_68188 68189 HTX/Hcj D. F. Kohn, Inst. of Comparative Medicine,Columbia University, to University of Florida 1992 at F30. Department of Pharmacology, University of Florida, Gainesville. inbred Unknown RRID:RGD_68189 69369 SS From a colony of Sprague-Dawley outbred rats developed by LK Dahl, Brookhaven National Laboratories, Upton, New York, selected for sensitivity to salt-induced hypertension (Dahl et al 1962a,b, Rapp 1982). Also designated S/JR by Rapp (1984), who gives an extensive review of the characteristics of the strain, and Dahl S by Mollegard, Copenhagen. Note that the Dahl selected strain has been independently inbred at the NIH, and designated DSS/N. There is likely to be confusion among these colonies unless considerable care is taken with nomenclature. Stlezin et al (1992) found that SS and SR had about 80% of DNA fingerprint bands in common, compared with 50% between SHR and WKY. According to Ginn et al, (1993) analysis of RFLPs and microsatellites suggest that SR is a reasonably good control strain for SS, though crosses between SS and unrelated normotensive strains will be useful in identifying the loci responsible for salt-induced hypertension. Brookhaven National Laboratories, Upton, New York inbred Unknown RRID:RGD_69369 69638 BN/Ka Brown Norway Katholiek (kininogen or kinin deficient) Kitasato University, Kanagawa, Japan. Kitasato University, Kanagawa, Japan. inbred Unknown RRID:RGD_69638 69643 F344/DuCrlCrlj This strain originated in 1920 by Curtis then was with Dunning and then with Charles River Japan from 1976. Charles River Laboratories Japan, National BioResource Project for the Rat in Japan inbred Live Animals Neurobiology; Cardio Hypertension RRID:RGD_69643 70410 AA Alko, Alcohol Wistar rats were outbred and selected for breeding animals that differ in their alcohol consumption. Marked difference between the strains and sex was visible by the eighth generation. After puberty the animals were isolated and given 10% alcohol as drink for 10 days, after which they had access to water and alcohol for 4 weeks. The quantity of fluid intake was measured daily. Fluid intake of animals varied greatly in animals consuming the same amount of alcohol per unit body weight, so alcohol intake was used as a phenotypic measure. Research Laboratories of the State Alcohol Monopoly (Alko), Helsinki, Finland inbred Unknown RRID:RGD_70410 70411 ANA Alko, Non-Alcohol Wistar rats were outbred and selected for breeding animals that differ in their alcohol consumption. Marked difference between the strains and sex was visible by the eighth generation. After puberty the animals were isolated and given 10% alcohol as fluid for 10 days, then they had access to water and alcohol for 4 weeks. The quantity of fluid intake was measured daily, as fluid intake of animals varied greatly in animals consuming the same amount of alcohol per unit body weight. Therefore, alcohol intake was kept as a phenotypic measure. Research Laboratories of the State Alcohol Monopoly (Alko), Helsinki, Finland inbred Unknown RRID:RGD_70411 70413 WBB inbred Unknown RRID:RGD_70413 70416 ACH Curtiss and Dunning 1926 at Columbia University Institute for Cancer Research. inbred Unknown RRID:RGD_70416 70417 A28807/N Curtis and Dunning in 1936 as a subline of A7322 derived from a half-brother x sister mating at F15. To NIH in 1977 at F25 (Hansen et al 1982). NIH Autoimmune Rat Model Repository and Development Center inbred Extinct RRID:RRRC_00141 70418 A35322 Curtiss and Dunning 1942 from a mutation originating in an aunt x nephew cross at F27 of animals of strain A990. inbred Unknown RRID:RGD_70418 70419 A7322 Curtis 1925 at Columbia University Institute of Cancer Research. Spontaneous mammary tumours frequent. Resistant to Cysticercus. inbred Unknown RRID:RGD_70419 70420 A990 Curtiss 1921 at Columbia University Institute for Cancer Research. inbred Unknown RRID:RGD_70420 70421 AAW Atomic Energy Commission, Melbourne (Adams et al 1984). inbred Unknown RRID:RGD_70421 70422 ABH Yamada from a cross between BN and outbred Wistar stock, with selection for the above coat colour, as a stock for testing coat colour genes in albino strains (Yamada and Nakajima 1976). To Nishimura, Hammatsu University School of Medicine, Japan. Nishimura, Hammatsu University School of Medicine, Japan. inbred Unknown RRID:RGD_70422 70423 ACP Dunning to National Cancer Institute 1967 at F54. inbred Unknown RRID:RGD_70423 70424 AGA Nakic, Zagreb (Stark et al 1968b). Used for immunological studies. inbred Unknown RRID:RGD_70424 70425 AGUS Germ-free strain developed by Gustafsson from stock (Sprague-Dawley?) by hysterectomy derivation in 1948 at F10. To Laboratory Animals Centre, Carshalton 1968 at F26. inbred Unknown RRID:RGD_70425 70426 ALB/N Albany Wolf and Wright, Albany Medical College in an attempt to develop a strain with a high incidence of spontaneous tumours, to NIH in 1950. No inbreeding records prior to transfer. NIH Autoimmune Rat Model Repository and Development Center inbred Unknown RRID:RGD_70426 70427 AM Torres, Rio de Janeiro, from outbred stock. inbred Unknown RRID:RGD_70427 70428 AMDIL Torres, Rio de Janeiro, from outbred stock inbred Unknown RRID:RGD_70428 70429 AO From ARC Compton, probably as "WAG", to Gowans, Oxford 1957. Appears to differ from other WAG sublines in having A at the agouti locus. Resistant to the development of experimental allergic encephalomyelitis upon treatment with a myelin basic protein-specific T cell line derived from an F1 hybrid between resistant AO and susceptible DA strain rats. This resistance was not abrogated by deletion of host's leukocytes using sublethal irradiation and cytotoxi drugs (Mostaricastrojkovic et al, 1992). Susceptible (2/4) to ocular infection with herpes simplex virus. PVG was relatively resistant (Nicholls et al, 1994). Met-enkephalin decreased H2O2 production by macrophages (contrast DA) (Radulovic et al, 1995). inbred Unknown RRID:RGD_70429 70440 BIRMA AM Mandl 1952 from Albino rats purchased from Birmingham market. inbred Unknown RRID:RGD_70440 70446 LIH/Lac Liverpool Hooded "Liverpool Hooded". Strain now probably extinct, but haematology described by Lovell et al (1981). unknown inbred Unknown RRID:RGD_70446 70447 MNR Maudsely non-reactive PL Broadhurst, 1954, from a commercial Wistar stock with selection for low defecation response in an open field. To Harrington 1965 at F25 and to National Institutes of Health 1964 at F18+. The strain was apparently inbred as a number of parallel sublines which differ at the agouti locus and major histocompatibility complex (Hansen et al 1982). unknown inbred Unknown RRID:RGD_70447 70448 MNRA Substrain of MNR. To Harrington in 1965 at F25 (Harrington 1981). inbred Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26) RRID:RGD_70448 70449 MR/N Maudsely reactive Origin: as for MNR except selection was for high defecation response in the open field. To Harrington in 1965 at F25 and to NIH in 1964 at F18+ (Hansen et al 1982). NIH Autoimmune Rat Model Repository and Development Center inbred Unknown RRID:RGD_70449 70450 NBR Poiley 1966 from heterogeneous stock inbred Unknown RRID:RGD_70450 70451 OKA From faculty of Medicine, Kyoto, Japan to Dr. J Roba, Machelen, Belgium 1970, to Dr. H Bazin 1971 (Bazin 1977). Should probably regarded as a subline of SHR, though skin grafts between OKA and SHR are rejected after 30-45 days. inbred Unknown RRID:RGD_70451 70452 OM Osborne-Mendel Heston 1946 from non-inbred Osborne-Mendel stock obtained from J White, to NIH at F10 (Hansen et al 1982). NIH Autoimmune Rat Model Repository and Development Center outbred Unknown RRID:RGD_70452 70453 SR Rapp from a Sprague-Dawley outbred colony developed by LK Dahl, Brookhaven National Laboratories, Upton, New York, selected for resistance to salt-induced hypertension (Dahl et al 1962a,b). Also designated R/JR by Rapp (1984), and Dahl R by Mollegard, Copenhagen. inbred Unknown RRID:RGD_70453 70454 WKY/N National Institutes of Health in 1971 from outbred Wistar stock from Kyoto School of Medicine. Inbred as a normotensive control strain for SHR (Hanesn et al 1973), though there is some controversy about the validity of such use (see Rapp 1987). Johnson et al (1992) found large genetic differences using restriction fragment length polymorphisms between WKY and SHR, comparable to the maximum divergence possible between unrelated humans. Also, breeding stock of ths strain was distributed before F20, possibly resulting in the emergence of a number of strains or substrains (Kurtz and Morris 1987, Kurtz et al 1989). It is therefore essential that subline codes are always used in designating this strain. NIH Autoimmune Rat Model Repository and Development Center, Rat Resource and Research Center inbred Cryopreserved Embryo (as of 2019-02-01) RRID:RRRC_00190 70455 WKYO/Kyo Inbred in 1980 from outbred Wistar Kyoto rats. Highly sensitive to the development of experimental glomerulonephritis following injection of nephritogenic antigen from bovine renal basement membrane (1/10) (Naito et al, 1991). National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_70455 70456 WM Wistar Institute to Tokyo University in 1938. To Hokkaido in 1944. To National Institute of Genetics, Mishima in 1951. inbred Unknown RRID:RGD_70456 70457 WMS Munich, Germany from Wistar stock selectively bred for superficial glomeruli. To Sim via Veterans Administration Medical Center, San Francisco, California in 1979 at which time inbreeding was begun. Good reproductive performance. Has superficial glomeruli and prominant elongated renal papilla. See also MW and MWF inbred Unknown RRID:RGD_70457 70459 ZDF Vancouver diabetic fatty Zucker "Zucker" fatty rats of undefined outbred background, inbred with selection for non-insulin-dependent diabetes mellitus by mating diabetic homozygous fatty males to heterozygous sisters (Peterson et al 1990b). Animal Model Core Facility, University of California at Davis inbred Unknown RRID:RGD_70459 70508 SD Sprague-Dawley This strain was initiated by R. Dawley, Sprague-Dawley Company, Madison, Wisconsin in 1925. A hybrid hooded male of unknown origin was mated to a white female (Douredoure strain, probably Wistar) and subsequently to his white female offspring for 7 generations. All the current colonies are from this original stock. outbred Unknown Aqp1|Brca1|Brca2|Crebbp|Cyp11b1|Drd1|Edn1|Esr1|Gabrb1|Htr1b|Nos1|Nppa|Nppb|Prlr|Sdc1|Sdc4|Gpc1|Alox15|E2f5|Slc15a1|Cnga1|E2f1 2141|2218|2219|2401|2453|2518|2532|2581|2649|2846|3184|3193|3194|3407|3648|3650|61853|70493|621357|621736|621815|728892 RRID:RGD_70508 70509 F344/NRrrc Curtiss and Dunning 1920 at Columbia University Institute for Cancer Research,To Heston 1949 (Billingham and Silvers 1959). To National Institutes of Health in 1951 (Hansen et al 1982). Subsequent sublines from Dunning or NIH. NIH Autoimmune Rat Model Repository and Development Center, Rat Resource and Research Center inbred Cryopreserved Sperm Cdkn2a|Gfap|Tnfrsf1a 2323|2679|621237 RRID:RRRC_00158 625624 LETsc2Eker/Hin Eker rat is derived from the Long-Evans strain that has a mutation in Tsc2 gene. Originally reported by R. Eker in 1954 at the Norwegian Radium Hospital, Oslo. Department of Experimental Pathology, Cancer Institute, Toshima-ku, Tokyo Japan mutant Unknown Tsc2|Tsc2Eker 3908|12791989 10 13848210 13883189 1 - by flanking markers 10 13778990 13813725 1 - by flanking markers 10 13962006 13996684 1 - by flanking markers 10 13621135 13655773 1 - by flanking markers RRID:RGD_625624 625659 DRH/Seac Established by inbreeding closed colony of Donryu rats ( purchased from SEAC Yoshitomi, Ltd. Fukuoka, Japan) for more than 20 generations, their diet continously contained a hepatocarcinogen 3 National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Cancer RRID:RGD_625659 628372 ACI.FHH-(D1Mit34-D1Rat156)/Eur The Rf-1 region of chromosome 1 which is between the D1Mit34 and D1Rat156 is transferred from FHH to the genomic background of ACI. Animal Research Center of the Erasmus University, Rotterdam, The Netherlands congenic Unknown 1 230963695 253410500 1 - by flanking markers 1 252776360 279213254 1 - by flanking markers 1 245529606 245529710 1 - by flanking markers 1 225126575 225126682 1 - by flanking markers RRID:RGD_628372 628486 NER/Kyo Noda epileptic rat, GMS Originated in a group of Crj:Wistar rats which were developed and maintained at the Research Institute for Animal Science in Biotechnology and Toxicology, Kanagawa, Japan. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Neurobiology RRID:RGD_628486 628525 Ni/Hin Found in the Sprague-Dawley (Jci:SD) in Japan. In these the Tsc2 gene is not mutated. In this rat strain mutation was identified as an insertion of a cytosine (C) in a C tract within exon 3 of Flcn . This germline mutation results in a frameshift and produces a stop codon 26 amino-acids downstream Clea Japan Inc. Shiga inbred Unknown RRID:RGD_628525 628907 SHR.BN-RT1n This strain is derived by transferring a segment from chr. 20 which contains the major histocompatibility complex of the BN-Lx strain onto SHR. congenic Unknown RRID:RGD_628907 628908 SHR.BN-(D1Mit3-Igf2)/Ipcv Segment of chromosome 1 from the normotensive BN/Cr was transferred to SHR. After 10 generations of backcrossing to SHR, the differential segment was fixed with the flanking markers.These were maintained in the homozygous state by brother x sister mating. Czech Academy of Sciences, Prague, Czech Republic congenic Unknown Igf2|Sa|Scnn1b|Scnn1g 2870|3616|3640|3641 1 146971846 202915231 1 - by flanking markers 1 162692213 222733868 1 - by flanking markers 1 156446196 215839081 1 - by flanking markers 1 144267353 197831802 1 - by flanking markers RRID:RGD_628908 628909 SHR.BN-(D13Arb5-Ren1)/Ipcv Segment of chromosome 13 from the normotensive BN/Crl was transferred to SHR. After 10 generations of backcrossing to SHR, the differential segment was fixed with the flanking markers.These were maintained in the homozygous state by brother x sister mating. The size of the chromosome transferred is 2.5 cM with an additional 16 cM region of heterozygosity. Czech Academy of Sciences, Prague, Czech Republic congenic Unknown 13 25430110 64281346 1 - by flanking markers 13 14281836 72173144 1 - by flanking markers 13 9016742 67207219 1 - by flanking markers 13 5994668 62022792 1 - by flanking markers RRID:RGD_628909 629459 ZUC-LeprfaSteJrpz-/- Obtained from Louisiana Sate University Medical Center, New Orleans by the Department of Physiology. Department of Physiology, Louisiana State University Medical Center, New Orleans, LA, USA mutant Unknown RRID:RGD_629459 629462 ZUC-LeprfaSte-/- This recessive fatty Zucker rat carries a mutation that occurred spontaneously in the 13M stock and was reported by Lois Zucker and Theodore Zucker in 1960. This was observed during genetic experiments related to coat color and body size. University of California Davis, Davis, CA mutant Unknown Leprfa 13432153 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RRRC_00839 629463 ZUC-Lepr+Ste This is the littermate of ZUC-LeprfaSte-/-. The fa mutation occurred spontaneously in the 13M stock and was reported by Lois Zucker and Theodore Zucker in 1960. This was observed during genetic experiments related to coat color and body size. These rats have lean phenotype. University of California Davis, Davis, CA mutant Unknown Lepr 3001 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RGD_629463 629464 ZUC-Leprfa This fatty zucker is derived from Lois and Theodore Zucker colonies from which Research colonies were established at many institutions. mutant Unknown Leprfa 13432153 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RGD_629464 629465 SHR/NCrlCrlj NIH derived strain maintained at the Charles River, Japan. Charles River Japan, National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo Cardio Hypertension RRID:RGD_629465 629481 SHR.WKY-(D1Wox33-D1Got194) This congenic strain contains a WKY chromosome 1 segment containing QTLs affecting blood pressure and salt sensitivity transferred to the SHR background. Département de Physiologie et Pharmacologie Clinique, Faculté de Pharmacie, France congenic Unknown 1;2 160754901;198300754 208638156;198300855 1 - by flanking markers;1 - by flanking markers 1;2 174300636;224991853 228298222;224991955 1 - by flanking markers;1 - by flanking markers 1 221363524 221363653 1 - by flanking markers 1 203293397 203293528 1 - by flanking markers RRID:RGD_629481 629482 WKY.SHR-(D1Wox19-D1Mit2)/Njs Fragment of the chromosome 1 derived from SHR and repeated backcross to WKY University of Leicester, Leicester, UK congenic Unknown 1 134980526 185691036 1 - by flanking markers 1 204942418 204942572 1 - by flanking markers 1 197963658 197963812 1 - by flanking markers 1 181133855 181134010 1 - by flanking markers RRID:RGD_629482 629484 LEW-tl The outbred stock of Osborne Mendel rats maintained at the Great lakes Naval Training Station in early 1970s had the tl mutation. These rats donot survive to breed so this mutation was transferred to the LEW/N background by a series of backcrosses of heterozygous carriers to LEW/N. Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD congenic Unknown Csf1|Csf1tl 621063|12910954 RRID:RGD_629484 629485 LE/Stm The LE/Stm rats were introduced into Saitama Cancer Center Research Institute in 1969 from a closed colony of Long Evans rats maintained in the Ben May Laboratory for Cancer Research, University of Chicago. A mutant with red-eyed dilution was found in 1970 in the Long-Evans colony, and the mutation was fixed by selective mating. Thereafter, they were maintained by sister-brother mating more than F50. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Sperm Diabetes Obesity; Cancer RRID:RGD_629485 629486 PVG/OlaHsd black hooded, from A.R.C. Cambridge, United Kingdom; to Olac, United Kingdom, in 1979; to Harlan, United States, in 1992 Envigo inbred Cryorecovery RRID:RGD_629486 629487 SHR.WKY-(D1Wox19-D1Wox34)/Njs Fragment of the chromosome 1 derived from WKY and repeated backcross to SHR University of Leicester, Leicester, UK congenic Unknown 1 168382195 185691036 1 - by flanking markers 1 182435050 204942572 1 - by flanking markers 1 175447029 197963812 1 - by flanking markers 1 164747424 181134010 1 - by flanking markers RRID:RGD_629487 629488 SI-Tg(Ednrb)Ywa transgenic spotting lethal A 5.8 kb fragment of the human dopamine-beta-hydroxylase (DbH) promoter used directs rat Endrb expression in sl animals. University of Texas Southwestern Medical Center, Dallas, Texas transgenic Unknown Ednrb|Ednrbsl 2536|10755424 RRID:RGD_629488 629489 Eker-Tg(Tsc2)5Hin Wild type Tsc2 transgene was constructed from the Tsc2 cDNA from BN rat and was microinjected into single male pronuclei. Eggs were cultured and tranferred into female wistar which were mated with Eker rats. Department of Experimental Pathology, Cancer Institute, Toshima-ku, Tokyo, Japan transgenic Unknown Tsc2 3908 RRID:RGD_629489 629490 DA.F344-Aia1/1 genomic segments with region of interest from chr 20 were inserted to DA strain National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland congenic Unknown 20 2790511 32560683 1 - by flanking markers 20 5249981 36993999 1 - by flanking markers 20 3151815 3172069 1 - by flanking markers 20 2646395 2666654 1 - by flanking markers RRID:RGD_629490 629491 DA.F344-Aia1/2 genomic segments with region of interest from chr 4 were inserted to DA strain National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland congenic Unknown 4 36592628 85014222 1 - by flanking markers 4 37534124 151090861 1 - by flanking markers 4 37685175 86438507 1 - by flanking markers 4 39505275 85379614 1 - by flanking markers RRID:RGD_629491 629492 Sl Natural mutation in the progeny of a Wistar-Imamichi female and a wild rat. Institute of Animal Reproduction, Omiya, Japan mutant Unknown Ednrb|Ednrbsl 2536|10755424 15 87893141 87898700 1 - by flanking markers 15 91500400 91531979 1 - by flanking markers 15 88004775 88036354 1 - by flanking markers 15 80640839 80672115 1 - by flanking markers RRID:RGD_629492 629493 DA.F344-Aia1/3 genomic segments with region of interest from chr 4 were inserted to DA strain National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland congenic Unknown 4 54879077 54879214 1 - by flanking markers 4 55118586 55118722 1 - by flanking markers 4 55375865 55376001 1 - by flanking markers 4 56698790 56698927 1 - by flanking markers RRID:RGD_629493 629494 DA.F344-Aia1/4 genomic segments with region of interest from chr 10 were inserted to DA strain National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland congenic Unknown 10 24006429 24006612 1 - by flanking markers 10 24340447 107484761 1 - by flanking markers 10 24483076 107857673 1 - by flanking markers 10 23444813 104060283 1 - by flanking markers RRID:RGD_629494 629495 WKY.SHRSP-(Mt1pa-D1Rat57)/Bbb Fragment of the chromosome 1 derived from SHRSP and repeated backcross to WKY Freie Universitdt Berlin, Berlin, Germany congenic Unknown Mt1-ps1 3118 1 177313819 185690396 1 - by flanking markers 1 195736433 204941832 1 - by flanking markers 1 188794419 197963072 1 - by flanking markers 1 173421600 181133270 1 - by flanking markers RRID:RGD_629495 629499 BXS/Ipcv These recombinant inbred strains are obtained by crossing normotensive BN-Lx/Cub with hypertensive SHR/Ola progenitor strains. Czechoslovak Academy of Sciences, Prague recombinant_inbred Unknown RRID:RGD_629499 629500 LEXF/Stm Recombinant inbred strain derived from LE/Stm (derived from Ben May, Laboratory for Cancer Research, University of Chicago, Chicago IL) and F344/Stm (derived from F344/DuCrlj; Charles River Japan) and then maintained by brother-sister mating. Saitama Cancer Center Research Institute, 818 Komuro Saitama, Japan recombinant_inbred Unknown RRID:RGD_629500 629501 SD-Tg(Ren2)27 This is a hypertensive rat strain in which the mouse Ren2 renin gene along with its 5' and 3' flanking sequences were microinjected into fertilized eggs from a Hannover Sprague-Dawley (SD) background. Center for Genome Research, University of Edinburgh, UK transgenic Unknown Agtr1b|Ace 2071|2493 RRID:RGD_629501 629502 SHR.BN-(Il6-Npy) This congenic carries a chromosome 4 segment derived from BN/Crl (Charles River) and repeated backcross to SHR/NCruk and selection for Il6 and Npy heterozygotes MRC Clinical Centre, London, UK congenic Unknown Il6|Npy 2901|3197 4 456799 78045187 1 - by flanking markers 4 3095536 144240956 1 - by flanking markers 4 3043231 79565059 1 - by flanking markers 4 5214602 78888495 1 - by flanking markers RRID:RGD_629502 629503 SHR.BN-(D19Rat57-D19Mit7)/Ipcv The segment of chromosome 19 from BN/Crl was transferred onto the genetic background of SHR/Ola. After 8 generations of selective backcrossing the transferred segment had the Agt gene. This was fixed by intercrossing heterozygotes and maintained by by brother and sister mating. Czech Academy of Sciences, Prague, Czech Republic congenic Unknown Agt 2069 19 57234802 57235101 1 - by flanking markers 19 59599823 70892142 1 - by flanking markers 19 48798983 60220581 1 - by flanking markers 19 44306955 55283277 1 - by flanking markers RRID:RGD_629503 629504 WKY.SHR-(D1Mit3-D1Rat57)/Iwai Fragment of the chromosome 1 derived from SHR and repeated backcross to WKY Shiga University of Medical Science, Otsu, Japan congenic Unknown 1 146971846 177313977 1 - by flanking markers 1 162692213 195736590 1 - by flanking markers 1 156446196 188794576 1 - by flanking markers 1 144267353 173421758 1 - by flanking markers RRID:RGD_629504 629505 SS.MNS-(D10Mit11-D10M11Mit119)/Mco fragment of the chromosome 10 derived from MNS and repeated backcross to SS/Jr Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 101848470 101848683 1 - by flanking markers RRID:RGD_629505 629506 LEW-tl.BN-(D2Arb16-D2Wox8) LEW.tl carrier females were mated with BN/SsNHsd males to develop these congenic animals which has a 2.5 cM region of chr 2. Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD congenic Unknown Csf1 621063 2 198312439 212776982 1 - by flanking markers 2 225003539 237636701 1 - by flanking markers 2 205572952 219581453 1 - by flanking markers 2 190602746 204499414 1 - by flanking markers RRID:RGD_629506 629509 FHH/EurMcwi An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria. The colony was transferred to Erasmus University. PhysGen, Rat Resource and Research Center inbred Live Animals; Cryorecovery RRID:RRRC_00293 629510 SS.BN-(D12Arb13-D12Rat79)/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen congenic Live Animals 18 2848113 62229060 1 - by flanking markers 18 2761846 61177004 1 - by flanking markers 18 2745212 61985812 1 - by flanking markers 18 59796478 59796643 1 - by flanking markers RRID:RGD_629510 629511 SS-Chr 2BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_629511 629512 FHH-Chr 12BN/Mcwi A cross of FHH and BN strains which results in a FHH genomic background with a BN chromosome introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_629512 629513 SS-Chr 4BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_629513 629514 SS-Chr 6BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Live Animals; Cryopreserved Sperm RRID:RGD_629514 629515 SS-Chr 7BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_629515 629516 SS-Chr 8BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_629516 629517 SS-Chr YBN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_629517 629518 SS-Chr 9BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_629518 629519 SS.BN-(D13Mgh13-D13Mit4)/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen congenic Unknown 13 90551150 90551272 1 - by flanking markers 13 41256240 97381801 1 - by flanking markers 13 36147533 92916783 1 - by flanking markers 13 31241331 86800898 1 - by flanking markers RRID:RGD_629519 629520 FHH-Chr 1BN/Mcwi A cross of FHH and BN strains which results in a FHH genomic background with a BN chromosome introgressed PhysGen consomic Live Animals; Cryopreserved Sperm RRID:RGD_629520 629521 SS-Chr 11BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_629521 629522 SS-Chr 20BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_629522 629523 SS-Chr 13BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_629523 629524 SS-Chr 16BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Live Animals; Cryopreserved Sperm RRID:RGD_629524 629525 SS-Chr 18BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_629525 629548 SHR.BN-(D1Mit3-Igf2)/1lpcv SHR.BN-(D1Mit3-Igf2)/1lpcv is a subline of SHR.BN-(D1Mit3-Igf2)/lpcv. Czech Academy of Sciences, Prague, Czech Republic congenic Unknown RRID:RGD_629548 629578 SS.LEW-(D5Rat130-D5Mco10)/Jr A large segment of chr. 5 from LEW was inserted into Dahl salt-sensitive (SS/Jr) background, congenic substrains were developed by crossing SS.LEW to SS for 8 generations Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio. congenic Unknown 5 32701659 168174140 1 - by flanking markers 5 36590997 171686754 1 - by flanking markers 5 31926122 168109659 1 - by flanking markers 5 31663789 161481680 1 - by flanking markers RRID:RGD_629578 631158 DXE1/Ztm DXE1/Ztm is a recombinant inbred strain produced from a cross between DA/Han and E3/Han rats. Zentralinstitut Fur Versuchstierzucht, Hannover, Germany recombinant_inbred Unknown RRID:RGD_631158 631160 DXE2/Ztm Is a recombinant inbred strain produced from a cross between DA/Han and E3/Han rats Zentralinstitut Fur Versuchstierzucht, Hannover, Germany recombinant_inbred Unknown RRID:RGD_631160 631161 DXE3/Ztm Is a recombinant inbred strain produced from a cross between DA/Han and E3/Han rats. Zentralinstitut Fur Versuchstierzucht, Hannover, Germany recombinant_inbred Unknown RRID:RGD_631161 631163 LE/BluGill This inbred colony from the University of Illinois at Urbana-Champaign was derived from Long Evans Outbred rats originally purchased from Blue Spruce Farms, Altamont, NY in the Fall of 1982. In order to reduce individual differences, Principal Investigator, Martha U. Gillette, PhD, initiated inbreeding (consecutive brother-sister matings). In March 1993, the colony reached generation #20, defined by the Institute for Animal Laboratory Research (ILAR) as the point during inbreeding at which the strain can officially be considered inbred. This inbred colony continues to be used by Dr. Gillette and her laboratory at the University of Illinois at Urbana-Champaign to research cell, molecular and integrative mechanisms in the brain's circadian clock. University of Illinois at Urbana-Champaign inbred Unknown RRID:RGD_631163 631182 DA/BklArbN This is maintained in the NIH animal facility of the Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, Bethesda MD by brother and sister breeding. NIH, Arthritis and Rheumatism Branch, Bethesda MD inbred Extinct RRID:RRRC_00091 631219 SDT/Jcl Established from an outbred colony of Sprague-Dawley (purchased from Charles River Japan) in Torii Pharmaceutical Co. Ltd. This company was merged to CLEA Japan Inc. in 1998. This substrain was established in 1997. Rats with polyuria and glucosuria were bred for 20 generations of brother-sister mating. CLEA Japan, Inc inbred Live Animals (as of 2021-04-23) RRID:RGD_631219 631220 SS.LEW-(D10Mco1-D10Mco31)/Ayd Strains SS/Jr and LEW were bred for F1 then backcrossed to S to give BC1, this was backcrossed to S to give BC2 and so on till BC5, BC5 was crossed to S to duplicate the recombinant segment Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 10 69986912 84284667 1 - by flanking markers 10 68786307 83220224 1 - by flanking markers 10 69123603 83411656 1 - by flanking markers 10 66743655 80537228 1 - by flanking markers RRID:RGD_631220 631275 WKY/Cfd WKY/Cfd Substrain of WKY/Cr parents from a colony maintained at the Institut de Recherches Cliniques de Montreal (IRCM), the colony was derived from WKY/Cr parents obtained from Charles River (St. Constant, Quebec CA) Experimental Cardiovascular Biology Laboratory, Institut de Recherches Cliniques de Montreal, 119 Pine Ave W, Montreal, Quebec CA inbred Unknown RRID:RGD_631275 631276 WKHA/Cfd WKHA/Cfd Originated from a colony maintained at the Institut de Recherches Cliniques de Montreal (IRCM) Experimental Cardiovascular Biology Laboratory, Institut de Recherches Cliniques de Montreal, 119 Pine Ave W, Montreal, Quebec CA inbred Unknown RRID:RGD_631276 631278 SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc Congenic strain created by introgressing the Fst-D2Mgh12 (expanded to D2Rat13-D2Rat157) region from Chromosome 2 of WKY/Gcrc into the SHRSP/Gcrc background. University of Glasgow, Western Infirmary, Glasgow, UK congenic Unknown Fst|Gstm1|Vcam1|S1pr1 2633|2755|3952|61958 2 46542246 210636169 1 - by flanking markers 2 65576721 235592880 1 - by flanking markers 2 46537589 217498710 1 - by flanking markers 2 46123260 202447032 1 - by flanking markers RRID:RGD_631278 631279 SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc Congenic strain created by introgressing the Fst-D2Mit5 region from Chromosome 2 of WKY/Gcrc into the SHRSP/Gcrc background in the lab of Dr Anna Dominiczak, University of Glasgow. University of Glasgow, Western Infirmary, Glasgow, UK congenic Unknown Fst 2633 2 46542246 66680209 1 - by flanking markers 2 65576721 86560306 1 - by flanking markers 2 46537589 66828236 1 - by flanking markers 2 46123260 66118463 1 - by flanking markers RRID:RGD_631279 631280 WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc Congenic strain created by introgressing the D2Mit5-D2Mgh12 region from Chromosome 2 of SHRSP/Gcrc into the WKY/Gcrc background in the lab of Dr Anna Dominiczak, University of Glasgow. University of Glasgow, Western Infirmary, Glasgow, UK congenic Unknown Pklr 3336 2 66680022 181223505 1 - by flanking markers 2 86560119 207874394 1 - by flanking markers 2 66828049 188458034 1 - by flanking markers 2 66118275 174551863 1 - by flanking markers RRID:RGD_631280 631281 WKY.SHRSP-(Fst-Pklr)/Gcrc Congenic strain created by introgressing the Fst-Pklr region from Chromosome 2 of SHRSP/Gcrc into the WKY/Gcrc background in the lab of Dr Anna Dominiczak, University of Glasgow. University of Glasgow, Western Infirmary, Glasgow, UK congenic Unknown Fst|Pklr 2633|3336 2 46542246 181223505 1 - by flanking markers 2 65576721 207874394 1 - by flanking markers 2 46537589 188458034 1 - by flanking markers 2 46123260 174551863 1 - by flanking markers RRID:RGD_631281 631282 DA.F344-(D10Arb20-D10Arb22)/Arb This speed congenic strain contains an F344 chromsome 10 segment transferred to a DA background. Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA congenic Extinct 10 24006429 24006612 1 - by flanking markers 10 24340447 107484761 1 - by flanking markers 10 24483076 107857673 1 - by flanking markers 10 23444813 104060283 1 - by flanking markers RRID:RGD_631282 631283 DA.F344-(D10Arb21-D10Arb22)/Arb This congenic substrain contains an F344 chromosome 10 segment transferred to a DA background. Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA congenic Extinct 10 14721135 14721325 1 - by flanking markers 10 14644150 107484761 1 - by flanking markers 10 14827894 107857673 1 - by flanking markers 10 14487011 104060283 1 - by flanking markers RRID:RGD_631283 631285 IER/Ihr A mutant rat strain which is a useful model for human cataract. Institute of Experimental Animals of Shiga University, Medical Science, Ohtsu, Japan, National BioResource Project for the Rat in Japan inbred Live Animals Neurobiology; Ophthalmology RRID:RGD_631285 631286 WKY/Izm Wistar-Kyoto WKY strain from the Izumo colony National BioResource Project for the Rat in Japan inbred Live Animals RRID:RGD_631286 631294 F344.GK-(D1Arb42a-D1Rat90)/Swe This congenic strain carries a GK chromosome 1 segment defined by markers D1Arb42a and D1Rat90 transferred to the F344 background Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden congenic Unknown Cyp2c12 2470 1 267110921 267111153 1 - by flanking markers 1 266156838 289137268 1 - by flanking markers 1 258709726 281795785 1 - by flanking markers 1 238699859 259647894 1 - by flanking markers RRID:RGD_631294 631571 SS.LEW-(D1Uia8-D1Mco38)/Jr Segment of chr 1 from Lewis which was obtained from Charles was introgressed into Dahl salt-sensitive strain which is an in-house colony. Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown 1 110818690 110818887 1 - by flanking markers 1 117836211 117836407 1 - by flanking markers 1 116680361 116680557 1 - by flanking markers 1 110159449 110159650 1 - by flanking markers RRID:RGD_631571 631572 SBH/Ygl Sabra hypertension prone Bred from the original SBH colony established by Ben-Ishay at the Hebrew University Medical Center in Jerusalem. The original colony was found to be partly outbred and display phenotypic variability. To purify the colony and establish phenotypic homogeneity breeding pairs from the original colony were transferred to Ben Gurion University Barzilai Medical Center in Ashkelon, Israel in 1992 where renewed secondary breeding was performed. Ben Gurion University Barzilai Medical Center, Ashkelon, Israel inbred Unknown RRID:RGD_631572 631573 SBN/Ygl Sabra hypertension resistant Bred from the original SBN colony established by Ben-Ishay at the Hebrew University Medical Center in Jerusalem. The original colony had been bred for 20+ generations but was found to be partly outbred and display phenotypic variability. To purify the colony and establish phenotypic homogeneity breeding pairs from the original colony were transferred to Ben Gurion University Barzilai Medical Center in Ashkelon, Israel in 1992 where renewed secondary breeding was performed. Ben Gurion University Barzilai Medical Center, Ashkelon, Israel inbred Unknown RRID:RGD_631573 631574 Wild/K Wild rats were captured in Rostock, Greifswald, in an industrial pig farm near Greifswald and some in a farm near Munich in Germany. Department of Laboratory Animal Science, Greifswald, Karlsburg, Germany wild Unknown RRID:RGD_631574 631576 LEW/CrlCrlj Developed by Dr. Lewis from Wistar stock in the early 1950s. To CRL from Tulane in 1970 at F34. Charles River, Atsugi, Japan, National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo Immunology; Osteosis RRID:RGD_631576 631577 SHR/Izm Strain originated in 1963 from outbred Wistar Kyoto rats. Bred from a male with mild hypertension, mated with a female with high blood pressure. Brother x sister mating with continued selection for high blood pressure (Okamoto 1969, Okamoto et al 1972). National BioResource Project for the Rat in Japan, Funabashi Farm, Chiba, Japan inbred Live Animals Cardio Hypertension RRID:RGD_631577 631578 SHR.BN-(D2Rat171-D2Arb24)/Ipcv This congenic strain carries a BN/Crl chromosome 2 segment transferred to the SHR/OlaIpcv background Institute of Physiology, Czech Academy of Sciences, Prague 4, Czech Republic. congenic Unknown 2 116874922 221284686 1 - by flanking markers 2 135770850 248088631 1 - by flanking markers 2 116075644 228737869 1 - by flanking markers 2;9 112456140;67703258 212696837;67703293 1 - by flanking markers;1 - by flanking markers RRID:RGD_631578 631579 LEW/OlaHsd Obtained from Harlan UK, and for this study kept at the Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Harlan France inbred Unknown RRID:RGD_631579 631581 LEW.1F Originally derived by Dr. Hans J. Hedrich at Versuchstierzucht, Hannover, Germany by transgressing the RT1f haplotype into the LEW stock Zentralinstitut fur versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_631581 631582 SS.WKY-(Mme-D2Wox18)/Mco Fragment of the chromosome 2 from WKY was transferred to SS/Jr background and repeated backcross to SS/Jr Medical College of Ohio, Toledo, Ohio, USA congenic Unknown Mme 3098 2 153031724 174727552 1 - by flanking markers 2 173193501 201402094 1 - by flanking markers 2 153799203 181987474 1 - by flanking markers 2 147686913 168355276 1 - by flanking markers RRID:RGD_631582 631583 SS.WKY-(D2Mgh8-D2Mgh9)/Mco Fragment of the chromosome 2 from WKY was transferred to SS/Jr background and repeated backcross to SS/Jr Medical College of Ohio, Toledo, Ohio, USA congenic Unknown RRID:RGD_631583 631585 SS.LEW-(D16Mit2-D16Rat12)/Ayd This congenic strain carries a LEW/NCrlBR chromosome 16 segment transferred to the SS/Jr background Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 16 350121 4304517 1 - by flanking markers 16 1084304 5038806 1 - by flanking markers 16 1090054 5098704 1 - by flanking markers 16 380245 4227730 1 - by flanking markers RRID:RGD_631585 631586 SS.MNS-(D10Mco14-D10Mit11)/Jr This congenic strain is derived by introgressing a desired region of chr 10 from MNS to the SS/Jr recipient. Medical College of Ohio, Toledo congenic Unknown 10 45105978 102587587 1 - by flanking markers 10 44914976 101157704 1 - by flanking markers 10 45157430 101482600 1 - by flanking markers 10 43593509 98003205 1 - by flanking markers RRID:RGD_631586 631587 SS.MNS-(D10M11Mit119-D10Mit11)/Jr This congenic strain is derived by introgressing a desired region of chr 10 from MNS to the SS/Jr recipient. Medical College of Ohio, Toledo congenic Unknown Ace 2493 10 69986912 102587587 1 - by flanking markers 10 68786307 101157704 1 - by flanking markers 10 69123603 101482600 1 - by flanking markers 10 66743655 98003205 1 - by flanking markers RRID:RGD_631587 631588 SS.MNS-(D10Mit11-Vamp2)/Mco Fragment of the chromosome 10 derived from MNS and repeated backcross to SS/Jr Medical College of Ohio, Toledo, Ohio, USA congenic Unknown Vamp2 3949 10 55848264 101848683 1 - by flanking markers 10 55418231 55422465 1 - by flanking markers 10 55675171 55679405 1 - by flanking markers 10 53793581 53797815 1 - by flanking markers RRID:RGD_631588 631589 SHR.WKY-(D1Wox34-D1Rat164)/Njs Congenic substrain derived by backcrossing congenic strain SHR.WKY-(D1Wox19-D1Wox34) to SHR Dept. Cardiology, Univ of Leicester, Clinical Sciences Wing. Glenfield Hospital, Groby Rd, Leicester, UK congenic Unknown 1 168382195 170218440 1 - by flanking markers 1 182435050 184213712 1 - by flanking markers 1 175447029 177235302 1 - by flanking markers 1 164747424 166533203 1 - by flanking markers RRID:RGD_631589 631590 SHR.WKY-(D1Wox34-Sah)/Njs Congenic substrain derived by backcrossing congenic strain SHR.WKY-(D1Wox19-D1Wox34) to SHR Dept. Cardiology, Univ of Leicester, Clinical Sciences Wing. Glenfield Hospital, Groby Rd, Leicester, UK congenic Unknown Acsm3 62086 1 168382195 178081751 1 - by flanking markers 1 182435050 196475596 1 - by flanking markers 1 175447029 189541233 1 - by flanking markers 1 164747424 174159966 1 - by flanking markers RRID:RGD_631590 631591 WKY.SHR-(D1Rat56-D1M7Mit206)/Njs Congenic substrain derived by backcrossing congenic strain WKY.SHR-(DWox19-D1Mit2) to WKY Dept. Cardiology, Univ of Leicester, Clinical Sciences Wing. Glenfield Hospital, Groby Rd, Leicester, UK congenic Unknown 1 172926151 172926455 1 - by flanking markers 1 191393321 191393468 1 - by flanking markers 1 184419946 184420093 1 - by flanking markers 1 169112897 169113045 1 - by flanking markers RRID:RGD_631591 631592 WKY.SHR-(D1Rat236-D1M7Mit206)/Njs Congenic substrain derived by backcrossing congenic strain WKY.SHR-(D1Wox19-D1Mit2) to WKY Dept. Cardiology, Univ of Leicester, Clinical Sciences Wing. Glenfield Hospital, Groby Rd, Leicester, UK congenic Unknown 1 155183458 155183662 1 - by flanking markers 1 169098399 169098603 1 - by flanking markers 1 162891429 162891633 1 - by flanking markers 1 152234464 152234669 1 - by flanking markers RRID:RGD_631592 631593 LEW/Rj Strain first obtained in 1987 from the Centre de Selection et d’Elevage d’Animaux de Laboratoire (CSEAL, Orl´eans, bred at Janvier breeding centre (Le Genest-Saint-Isle, France). Hopital Purpan, Toulouse Cedex, France inbred Unknown RRID:RGD_631593 631594 BN/Rj Strain first obtained in 1987 from the Centre de Selection et d?Elevage d?Animaux de Laboratoire (CSEAL, Orl´eans, bred at Janvier breeding centre (Le Genest-Saint-Isle, France). Hopital Purpan, Toulouse Cedex, France; Centre D'Elevage R. Janvier, Route des Chenes-Secs Le Genest-St-Isle, France inbred Unknown RRID:RGD_631594 631595 LEW.1AV1.DA-(D10Rat92-D10Rat135)/Ubc LEW.1AV1 x DA F1 was backcrossed to LEW.1AV1 for 9 generations with selection for the Oia3 locus using flanking markers, then F1N9F1 rats were used as founders for the Oia3 congenic strain. Biomedical Center in Uppsala, Sweden congenic Unknown 10 78170416 108776963 1 - by flanking markers 10 77132487 108145987 1 - by flanking markers 10 77269759 108540162 1 - by flanking markers 10 74585846 104670812 1 - by flanking markers RRID:RGD_631595 631596 LEW.1AV1.DA-(D10Rat92-D10Wox17)/Ubc Congenic substrain derived from intercrosses of the Oia3-congenic strain (LEW.1AV1.DA-(D10Rat20-D10Mgh1)x LEW.1AV1)F2. Biomedical Center in Uppsala, Sweden congenic Unknown 10 78170416 91168491 1 - by flanking markers 10 77132487 89831596 1 - by flanking markers 10 77269759 90042115 1 - by flanking markers 10 74585846 87055282 1 - by flanking markers RRID:RGD_631596 631597 LEW.1AV1.DA-(D10Wox17-D10Rat135)/Ubc Congenic substrain derived from intercrosses of the Oia3 containing strain (LEW.1AV1.DA-(D10Rat20-D10Mgh1)x LEW.1AV1)F2 Biomedical Center in Uppsala, Sweden congenic Unknown 10 91168332 108776963 1 - by flanking markers 10 89831438 108145987 1 - by flanking markers 10 90041957 108540162 1 - by flanking markers 10 87055121 104670812 1 - by flanking markers RRID:RGD_631597 631598 LEW.1AV1.DA-(D10Got154-D10Rat135)/Ubc Congenic substrain derived from the Oia3 containing strain intercrosses of (LEW.1AV1.DA-(D10Rat20-D10Mgh1)x LEW.1AV1)F2 Biomedical Center in Uppsala, Sweden congenic Unknown 10 101532360 108776963 1 - by flanking markers 10 100150192 108145987 1 - by flanking markers 10 100460820 108540162 1 - by flanking markers 10 97010147 104670812 1 - by flanking markers RRID:RGD_631598 631599 SHRSP/Izm Strain has been maintained at Kyoto University. National BioResource Project for the Rat in Japan inbred Live Animals Cardio Hypertension; Neurobiology RRID:RGD_631599 631600 WKY.SHRSP-(Mt1pa-D1Rat200)/Bbb Fragment of the chromosome 1 derived from SHRSP and repeated backcross to WKY Max-Delbruck-Center for Molecular Medicine, Freie Universitat Berlin, Berlin, Germany. congenic Unknown Mt1-ps1 3118 1 126938969 185690396 1 - by flanking markers 1 134116233 204941832 1 - by flanking markers 1 133076978 197963072 1 - by flanking markers 1 125611501 181133270 1 - by flanking markers RRID:RGD_631600 631601 WKY.SHRSP-(Asgr1-Vamp2)/Bbb Both the strains WKY and SHRSP were from University of Heidelberg, Heidelberg, Germany; The SHRSP was originated in 1974 from Okamoto and Aoki Max-Delbruck Center for Molecular Medicine, Germany congenic Unknown Asgr1|Vamp2 2160|3949 10 55848264 56903173 1 - by flanking markers 10 55418231 56411205 1 - by flanking markers 10 55675171 56666086 1 - by flanking markers 10 53793581 54779642 1 - by flanking markers RRID:RGD_631601 631602 BN/Elh These rats were transferred in 1986, from University of Pittsburgh, at 35 generation to University of Otago, New Zealand and have been continuously inbred in a hysterectomy-derived barrier-sustained colony. Department of Surgery and Biochemistry, University of Otago inbred Unknown RRID:RGD_631602 631603 WKY/Snk The original WKY animals were bred at the Animal Science and Toxicology Laboratories in Japan. Animal Science and Toxicology Laboratories, Sankyo Co. Ltd., Shizuoka, Japan inbred Unknown RRID:RGD_631603 631604 SHR/Snk The original WKY animals were bred at the Animal Science and Toxicology Laboratories in Japan. Animal Science and Toxicology Laboratories, Sankyo Co. Ltd., Shizuoka, Japan inbred Unknown RRID:RGD_631604 631605 SS.LEW-(D10Arb9-D10Got101)/Jr Congenic strain originated from an inbred SS/Jr strain. Medical College of Ohio, Toledo congenic Unknown 10 65068360 77547622 1 - by flanking markers 10 65339106 73694285 1 - by flanking markers 10 76420583 76420889 1 - by flanking markers 10 73887148 73887455 1 - by flanking markers RRID:RGD_631605 631606 SS.MNS-(D10Rat13-D10Mit11)/Jr Congenic strain originated from an inbred SS/Jr strain. Medical College of Ohio, Toledo congenic Unknown 10 97152234 101848683 1 - by flanking markers 10 95701164 95701443 1 - by flanking markers 10 95967019 95967298 1 - by flanking markers 10 92698959 92699242 1 - by flanking markers RRID:RGD_631606 631607 SS.WKY-(D2N35-Mme)/Mco Fragment of the chromosome 2 from WKY was transferred to SS/Jr background and repeated backcross to SS/Jr Medical College of Ohio, Toledo, Ohio, USA congenic Unknown Mme 3098 2 153031724 153114515 1 - by flanking markers 2 173193501 173278946 1 - by flanking markers 2 153799203 153880910 1 - by flanking markers 2 147686913 147803808 1 - by flanking markers RRID:RGD_631607 631610 SS.LEW-(D1Rat39-D1Rat131)/Jr Segment of chr 1 from Lewis which is an in-house colony was introgressed into Dahl salt-sensitive strain which was obtained from Charles River. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 125983422 145648920 1 - by flanking markers 1 133172202 159182239 1 - by flanking markers 1 132134307 152871103 1 - by flanking markers 1 124668437 142990467 1 - by flanking markers RRID:RGD_631610 631691 SHRSP/A3Izm Substrain originates from the SHRSP/Izm strain. Research Institute, International Medical Center of Japan inbred Unknown RRID:RGD_631691 631693 WKY.SHRSP-(Shbg-Atp1b2)/Bbb This strain has the blood pressure locus from chr 10 Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown Atp1b2|Shbg 2171|3671 10 56418323 56435654 1 - by flanking markers 10 55951260 55983036 1 - by flanking markers 10 56205622 56237354 1 - by flanking markers 10 54318698 54350409 1 - by flanking markers RRID:RGD_631693 631694 WKY.SHRSP-(D1Rat200-D1Rat216)/Bbb This single chromosome 1 congenic strain was constructed by using the double congenic SHRSP strain WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2) as the donor strain to transfer the chromosome 1 Bp QTL to the WKY background while selecting against the chromosome 10 Bp QTL to retain only the chromosome 10 locus in strain WKY.SHRSP-(D1Rat200-D1Rat216) Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown 1 126938969 185923619 1 - by flanking markers 1 134116233 205161264 1 - by flanking markers 1 133076978 133164521 1 - by flanking markers 1 125611501 125611741 1 - by flanking markers RRID:RGD_631694 631695 SS/JrRkb This inbred strain was derived from the inbred SS/Jr strain available from Harlan Sprague-Dawley (Indianapolis, Ind, US). The colony was established in 1997 at the Freie Universitat Berlin Benjamin Franklin Klinikum, Freie Universitat Berlin, Hindenburgdamm 30, 12203 Berlin, Germany. inbred Unknown RRID:RGD_631695 631696 SHR/FubRkb Strain originated from an SHR/Fub strain obtained in 1997 at the Freie Universitat Berlin. Freie Universitat Berlin inbred Unknown RRID:RGD_631696 631697 BBDP/Hri This strain has been maintained by brother and sister mating for 40 generations. These originated from the Worcester colony from the rats that were sent from Ottawa to Worcester in 1977. Hagedorn Research Institute, Gentofte, Denmark inbred Unknown RRID:RGD_631697 631698 BN/Mol This strain is maintained at the Mollegaard breeding center. Mollegaard Breeding Centre Ltd., Denmark inbred Unknown RRID:RGD_631698 631699 BB.SHR-(D6Rat184-D6Rat101)/K Congenic strain originated from an inbred BB/OK strain crossed with diabetes-resistant SHR/Mol females. University of Greifswald, Germany congenic Unknown 6 121381065 135964844 1 - by flanking markers 6 130448688 144756005 1 - by flanking markers 6 121224054 135658578 1 - by flanking markers 6 116506292 130245370 1 - by flanking markers RRID:RGD_631699 631700 BB.SHR-(Gnal-D18Mit9)/K Diabetic BB/OK were crossed with male SHR/Mol and the resulting hybrids were backcrossed to BB/OK. Hybrids of each backross were analysed using microsatellite markers. After 7 backcrosses the animals were intercrossed and the ones which were homozygous to the SHR allele were selected. This fragment is 24cM long. Department of Laboratory Animal Science, University Greifswald, Karlsburg, Germany congenic Unknown Gnal 2715 18 63595606 80370517 1 - by flanking markers 18 61991738 79748387 1 - by flanking markers 18 62805406 80696375 1 - by flanking markers 18 60622311 77209844 1 - by flanking markers RRID:RGD_631700 631703 SS.LEW-(D10Rat207-D10Mgh1)/Ayd Congenic strain originated from an inbred SS strain Research Centre-CHUM congenic Unknown 10 89896421 89896564 1 - by flanking markers 10 88662536 88662678 1 - by flanking markers 10 88865454 88865596 1 - by flanking markers 10 85887040 85887185 1 - by flanking markers RRID:RGD_631703 631844 Iusm:HAD1 high-alcohol-drinking These high-alcohol-drinking rats were developed by selective breeding from the heterogeneous N/N (N:NIH) strain . 8 inbred rat strains were intercrossed for alcohol preference and consumption.Within-family selection and a rotational breeding design were employed to reduce inbreeding and to allow maintenance of non-inbred replicate lines. Replicate lines were independently selected for high alcohol drinking (HAD1 and HAD2). Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana outbred Unknown RRID:RGD_631844 631845 Iusm:LAD1 low-alcohol-drinking These low-alcohol-drinking were developed by selective breeding from the heterogeneous strain N:NIH (RGD:728185). 8 inbred rat strains were intercrossed for alcohol preference and consumption. Within-family selection and a rotational breeding design were employed to reduce inbreeding and to allow maintenance of non-inbred replicate lines. Replicate lines were independently selected for low alcohol drinking (LAD1 and LAD2). Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana outbred Unknown RRID:RGD_631845 631846 F344.GK-(D1Mgh10-D1Rat90)/Swe Congenic strain originated from an inbred F344/Mcwi strain Karolinska Institute congenic Unknown 1 204280278 267111153 1 - by flanking markers 1 223910550 289137268 1 - by flanking markers 1 217054291 281795785 1 - by flanking markers 1 199050459 259647894 1 - by flanking markers RRID:RGD_631846 631847 F344.GK-(D1Mit7-D1Mgh25)/Swe Congenic strain originated from an inbred F344 strain Karolinska Institute congenic Unknown 1 235677487 240980321 1 - by flanking markers 1 257430524 262617374 1 - by flanking markers 1 250195095 250195290 1 - by flanking markers 1 229550480 229550676 1 - by flanking markers RRID:RGD_631847 631848 SHR/OlaIpcv These are descendents of SHR which were originally from National Institutes of Health. It has been maintained by brother x sister mating at the Czech Academy of Sciences for more than 15 years. A spontaneous recessive mutation in intron 37 (-1 of exon 38) of Sbf1 was identified in this strain. Czech Academy of Sciences, Prague, Czech Republic inbred Unknown Sbf1m1Ipcv 10002755 RRID:RGD_631848 634359 WF.WKY-(D5Pas1-D5Uwm37)/Uwm WKY/NHsd rats, carrying a region for resistance to mammary tumors between D5Wox7 and D5Uwm37 on chromosome 5 were mated to WF/NHsd. Progeny were backcrossed to WF for 8-9 generations, selecting for Mcs5 region. University of Wisconsin-Madison congenic Unknown 5 26938679 130527490 1 - by flanking markers 5 30952629 132652105 1 - by flanking markers 5 26251767 128812854 1 - by flanking markers 5 26141669 123935338 1 - by flanking markers RRID:RGD_634359 634363 LEW/NIcoCrlf A substrain of LEW that was purchased from Charles River France and bred at Institut Francois Magendie, Bordeaux Cedax, France. Charles River, France inbred Unknown RRID:RGD_634363 634364 SHR/NIcoCrlf A substrain of SHR that was purchased from Charles River France and bred at Institut Francois Magendie, Bordeaux Cedax, France. Charles River, France inbred Unknown RRID:RGD_634364 634365 SS/Hsd This strain carries the systolic blood pressure QTL BP143 and the cholesterol-related QTLs Scl14, Scl15, Scl16, Scl17 and Scl18. Harlan, Indianapolis, Indiana inbred Unknown RRID:RGD_634365 634366 SR/Hsd This strain carries the systolic blood pressure QTL BP143 and the cholesterol-related QTLs Scl14, Scl15, Scl16, Scl17 and Scl18. Harlan, Indianapolis, Indiana inbred Unknown RRID:RGD_634366 634367 BN/CrlCrlj 1976's American River CHARUSU Radiobiology Institute (Netherlands) introduced. After the SPF, the cesarean CHARUSU River Japan again in 1990 (stock) was introduced. Charles River Laboratories Japan, National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo Ophthalmology; Immunology RRID:RGD_634367 634369 WBN/KobSlc wistar bonn/kobori This strain carries the body weight QTLs Bw12 and Bw13, the chronic pancreatitis and diabetes melllitus QTL Cpdm1 and the pancreas inflammation QTL Pi1. National BioResource Project for the Rat in Japan inbred Live Animals Diabetes Obesity; Ophthalmology RRID:RGD_634369 634370 F344.GK-(D1Mgh10-D1Rat119)/Swe GK rats, containing a region for susceptibility to development of type 2 diabetes between D1Mgh10-D1Rat110 on chromosome 1 were mated with normoglycemic F344 rats. Progeny were backcrossd onto F344 for 10 generations. Heterozygous animals were intercrossed to establish the congenic strain. Karolinska Institute congenic Unknown 1 204280278 242586311 1 - by flanking markers 1 223910550 264429516 1 - by flanking markers 1 217054291 256949019 1 - by flanking markers 1 199050459 236036450 1 - by flanking markers RRID:RGD_634370 634372 GHS SD rats were selectively bred for hypercalciuria through four generations to create the genetic hypercalciuric strain. Department of Medicine and Physiology, University of Rochester, Rochester, New York inbred Unknown RRID:RGD_634372 634373 DA/ZtmRhd DA rats originating from Zentralinstitut fur Versuchstierzucht, Hannover, Germany and kept at Lund University. Section for Medical Inflammation Research, Biomedical Center, Lund University, Sweden inbred Unknown RRID:RGD_634373 634374 E3/ZtmRhd E3 rats originating from Zentralinstitut fur Versuchstierzucht, Hannover, Germany and kept at Lund University. Section for Medical Inflammation Research, Biomedical Center, Lund University, Sweden inbred Unknown RRID:RGD_634374 634376 LEA/Ncu These rats were established from a closed colony of Long-Evans. Nagoya City University Medical School, Nagoya, Aichi, Japan inbred Unknown RRID:RGD_634376 634377 BN/Sea BN/Sea This inbred strain was obtained from Sea life Supply Sea Life Supply, Sand City, CA Sea Life Supply inbred Unknown RRID:RGD_634377 634380 iP/Iusm inbred alcohol-preferring These were inbred alcohol-preferring rats developed from outbred alcohol-preferring rats (Iusm:P) at generation 30 at Indiana University for high-alcohol-preferring behavior. Inbred rats utilized for the development of alcohol-preferring, alcohol-nonpreferring congenic strains were in the27th generation of inbreeding. Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana inbred Unknown Npy 3197 RRID:RGD_634380 634381 iNP/Iusm alcohol-nonpreferring These were inbred alcohol-nonpreferring rats developed from outbred alcohol-nonpreferring rats (Iusm:NP) at generation 30 at Indiana University for high-alcohol-nonpreferring behavior. Inbred rats utilized for the development of alcohol-preferring, alcohol-nonpreferring congenic strains were in the27th generation of inbreeding. Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana inbred Unknown Npy 3197 RRID:RGD_634381 634382 SHR.BN-(D5Wox12-D5Wox20)/Ipcv This congenic strain carries a BN/Crl chromosome 5 segment transferred to the SHR/OlaIpcv background Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic congenic Unknown 5 147065698 147065912 1 - by flanking markers 5 149494416 149494629 1 - by flanking markers 5 145726049 145726262 1 - by flanking markers 5 139989554 139989768 1 - by flanking markers RRID:RGD_634382 634743 BIL University of Pittsburgh from a mutation in a colony of unknown background held by the NIH. NIH Autoimmune Rat Model Repository inbred Unknown RRID:RGD_634743 724569 MWF/FubRkb Munich Wistar Fromter The MWF/FubRkb strain was established in generation F45 in 1996 by further inbreeding of rats obtained from the original colony (MWF/Ztm). Freie Universitdt Berlin, Berlin, Germany inbred Unknown RRID:RGD_724569 724570 LEW/Rkb The LEW/Rkb rats were obtained from M&B, Bomholtvej, Denmark, and a colony of was established at at the Freie Universitdt (FU) Berlin, Benjamin Franklin Hospital, Germany. Freie Universitdt Berlin, Berlin, Germany inbred Unknown RRID:RGD_724570 724571 MITE/Mna This strain was established from captured Japanese wild rats. Laboratory of Animal Reproduction, Nagoya University, Nagoya, Japan inbred Unknown RRID:RGD_724571 724572 SS.LEW-(D10Wox51-D10Rat27)/Ayd A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown 10 71294871 77092169 1 - by flanking markers 10 70062921 74127968 1 - by flanking markers 10 70428844 75983805 1 - by flanking markers 10 68011827 73453136 1 - by flanking markers RRID:RGD_724572 724573 SS/JrTol Dahl salt-sensitive (SS/Jr) rats In the 1960s, Dahl selectively bred rats for sensitivity (SS rats) to the hypertensive effect of high-salt diet. Housed at the University of Toledo College of Medicine and Life Sciences. inbred Live Animals (as of 2021-06-08) RRID:RGD_724573 724574 SHR/NHsd SHR strain obtained from Harlan Sprague-Dawley (Indianapolis, IN) Envigo inbred Unknown RRID:RGD_724574 724575 SS.LEW-(D10Rat17-D10Mgh1)/Ayd A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown 10 95066219 95066632 1 - by flanking markers 10 93641751 93641934 1 - by flanking markers 10 93886117 93886300 1 - by flanking markers 10 90627439 90627625 1 - by flanking markers RRID:RGD_724575 724576 KDP/Tky Komeda diabetes-prone rat This is a diabetic-prone substrain of LETL where only diabetic males were used for the backcross. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo Diabetes Obesity; Immunology Cblb 620535 RRID:RGD_724576 724577 SS.LEW-(D10Rat27-Igfbp4)/Ayd A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown Igfbp4 2875 10 77091834 87834315 1 - by flanking markers 10 74127825 86759484 1 - by flanking markers 10 75983662 86962563 1 - by flanking markers 10 73452992 84007272 1 - by flanking markers RRID:RGD_724577 728133 BN-RT1n/Rj This coisogenic strain was produced by selecting BN rats with the RT1n allele. The Center dElevage R. Janvier, France. coisogenic Unknown RRID:RGD_728133 728134 SS.LEW-(D1Rat35-D1Rat49)/Jr Inbred Salt-sensitive SS/Jr rats were mated to LEW/NCrl rats to create congenic strain. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 124748920 157498254 1 - by flanking markers 1 131958920 171330794 1 - by flanking markers 1 130917121 165129939 1 - by flanking markers 1 123479780 154464242 1 - by flanking markers RRID:RGD_728134 728135 SS.LEW-(D5Uwm14-D5Uwm31)/Jr S.LEW-D5Rat130/D5Mco10/Jr was selectively bred for 2 generation to fix the chromosome and then backcrossed with S strain Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614 congenic Unknown 5 48908533 48908825 1 - by flanking markers 5 52440414 52440705 1 - by flanking markers 5 47842131 47842422 1 - by flanking markers 5 47002982 47003274 1 - by flanking markers RRID:RGD_728135 728137 SS.LEW-(D10Rat141-D10Mgh1)/Ayd Strains SS/Jr and LEW were bred for F1 then backcrossed to S to give BC1, this was backcrossed to S to give BC2 and so on till BC5, BC5 was crossed to S to duplicate the recombinant segment Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 19 38295381 38295550 1 - by flanking markers 19 51402312 51402480 1 - by flanking markers 10;19 91548145;40571888 91548388;40572056 1 - by flanking markers;1 - by flanking markers 19 36511450 36511619 1 - by flanking markers RRID:RGD_728137 728138 SS.MNS-(Mme-Gca)/Ayd Segments from Milan normotensive rat were inserted in thre homologous region of Dahl salt-sensitive Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown Atp1a1|Mme|Npr1 2167|3098|3195 2 153031724 182740242 1 - by flanking markers 2 173193501 209287892 1 - by flanking markers 2 153799203 189857032 1 - by flanking markers 2 147686913 175950118 1 - by flanking markers RRID:RGD_728138 728139 WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb This double congenic strain was constructed by using the SHRSP strain as a donor strain to transfer the chromosome 1 Bp QTL to the chromosome 10 congenic strain in a cross between SHRSP and WKY.SHRSP-(Shbg-Atp1b2) to construct an F1 that was then backcrossed to the congenic WKY.SHRSP-(Shbg-Atp1b2) for more than 10 generations to construct the double congenic strain now homozygous for the SS Bp QTL alleles at both the chromosome 10 and chromosome 1 Bp QTLs Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown RRID:RGD_728139 728140 SS.LEW-(D10Rat11-D10Mgh1)/Ayd Strains SS/Jr and LEW were bred for F1 then backcrossed to S to give BC1, this was backcrossed to S to give BC2 and so on till BC5, BC5 was crossed to S to duplicate the recombinant segment Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 10;19 100633512;38295381 100633982;38295550 1 - by flanking markers;1 - by flanking markers 10;19 99184058;51402312 99184250;51402480 1 - by flanking markers;1 - by flanking markers 10;19 99492217;40571888 99492409;40572056 1 - by flanking markers;1 - by flanking markers 10;19 96120911;36511450 96121100;36511619 1 - by flanking markers;1 - by flanking markers RRID:RGD_728140 728142 BN.SHR-(Il6-Cd36)/Cub This congenic strain has a segment of chr 4 which was of SHR origin. The length of the differential segment is 10 cM and has a defective cd36 allele of SHR. Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic congenic Unknown Cd36|Il6 2301|2901 4 456799 13554416 1 - by flanking markers 4 3095536 14166434 1 - by flanking markers 4 3043231 14191498 1 - by flanking markers 4 5214602 17410084 1 - by flanking markers RRID:RGD_728142 728143 SS.LEW-(D1Mco38-D1Rat49)/Jr Inbred Salt-sensitive SS/Jr rats were mated to LEW/NCrl rats to create congenic strain. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 110818690 157498254 1 - by flanking markers 1 117836211 171330794 1 - by flanking markers 1 116680361 165129939 1 - by flanking markers 1 110159449 154464242 1 - by flanking markers RRID:RGD_728143 728144 BN.PD-(D8Rat39-D8Rat35)/Cub This congenic strain has a segment of chr 8 from the polydactylous PD/Cub by backcrossing to the BN/Cub. The length of the differential segment is 10-15 cM. Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic congenic Unknown 8 49035642 64617259 1 - by flanking markers 8 48981076 65325374 1 - by flanking markers 8 50356432 50356607 1 - by flanking markers 8 46358478 46358654 1 - by flanking markers RRID:RGD_728144 728145 SS.LEW-(D5Rat130-D5Rat108)/Jr S.LEW-D5Rat130/D5Mco10/Jr was selectively bred for 2 generation to fix the chromosome and then backcrossed with S strain Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614 congenic Unknown 5 32701659 134872385 1 - by flanking markers 5 36590997 137108002 1 - by flanking markers 5 31926122 133313852 1 - by flanking markers 5 31663789 128034027 1 - by flanking markers RRID:RGD_728145 728146 F344.BN-(D3Mgh13-D3Mgh7)/Dlw This congenic strain carries the BN Edpm3 QTL along with many BN chromosome 3 markers on an F344 background. This strain is maintained at Oakland University, Rochester MN, USA Department of Biological Sciences, Oakland University, Rochester, MI congenic Unknown 3 112319451 112319585 1 - by flanking markers 3 11139240 123812293 1 - by flanking markers 3 5775856 117288411 1 - by flanking markers 3 10549351 112272465 1 - by flanking markers RRID:RGD_728146 728147 BN.PD-(D8Rat39-D8Rat35),SHR-(D4Mgh2-Cd36),SHR-(D20Wox3-D20Mgh5)/Cub This is a triple congenic strain that has a differential segment of chr 8, major histocompatibility complex from chr 20 and a small segment of chr 4. The length of the differential segment on chr 20 is 20 cM and on chr 8 it is 15 cM. Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic congenic Unknown RRID:RGD_728147 728148 SS.LEW-(D16Uia2-D16Rat12)/Ayd Strains SS/Jr and LEW were bred for F1 then backcrossed to S to give BC1, this was backcrossed to S to give BC2 and so on till BC5, BC5 was crossed to S to duplicate the recombinant segment Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 16 350121 4304517 1 - by flanking markers 16 1084304 5038806 1 - by flanking markers 16 1090054 5098704 1 - by flanking markers 16 380245 4227730 1 - by flanking markers RRID:RGD_728148 728151 UPL/Ncc The UPL rat strain was founded as a mutant with cataracts in a SD/CrljRbrc rat colony. Hiroshima University, School of Medicine, Hiroshima, Japan inbred Unknown RRID:RGD_728151 728152 SS.LEW-(D1Rat196-D1Mgh7)/Jr Inbred Salt-sensitive SS/Jr rats were mated to LEW/NCrl rats to create congenic strain. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 55083934 106445306 1 - by flanking markers 1 59282428 114601028 1 - by flanking markers 1 58354072 113593716 1 - by flanking markers 1 57336763 106047988 1 - by flanking markers RRID:RGD_728152 728153 SS.LEW-(D1Rat196-D1Rat49)/Jr Inbred Salt-sensitive SS/Jr rats were mated to LEW/NCrl rats to create congenic strain. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 55083934 157498254 1 - by flanking markers 1 59282428 171330794 1 - by flanking markers 1 58354072 165129939 1 - by flanking markers 1 57336763 154464242 1 - by flanking markers RRID:RGD_728153 728155 BBDR.BBDP-(D4Mit6-D4Mit7)/1Rhw This congenic strain was developed by cyclic cross-intercross breeding using diabetic prone and diabetic resistant BB rats. (DP x DR)F1 x DR cross intercross breeding was used to generate F2 lymphopenic rats. These were then genotyped for both the flanking markers of the Gimap5 gene. Department of Medicine, University of Washington, Seattle, Washington congenic Unknown 4 75732943 75733127 1 - by flanking markers 4 141978848 141979031 1 - by flanking markers 4 77307388 79562753 1 - by flanking markers 4 76647384 78886189 1 - by flanking markers RRID:RGD_728155 728156 SS.LEW-(D5Mco34-D5Mco10)/Jr SS.LEW-(D5Rat130-D5Mco10)/Jr was selectively bred for 2 generation to fix the chromosome and then backcrossed with S strain Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614 congenic Unknown 5 168173895 168174140 1 - by flanking markers 5 171686510 171686754 1 - by flanking markers 5 168109415 168109659 1 - by flanking markers 5 161481433 161481680 1 - by flanking markers RRID:RGD_728156 728157 SS.LEW-(D5Rat130-D5Mit19)/Jr SS.LEW-(D5Rat130-D5Mco10)/Jr was selectively bred for 2 generation to fix the chromosome and then backcrossed with SS strain Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614 congenic Unknown 5 32701659 140744137 1 - by flanking markers 5 36590997 142892672 1 - by flanking markers 5 31926122 139102349 1 - by flanking markers 5 31663789 133752767 1 - by flanking markers RRID:RGD_728157 728158 SS.LEW-(D5Uia4-D5Mco10)/Jr SS.LEW-(D5Rat130-D5Mco10)/Jr was selectively bred for 2 generation to fix the chromosome and then backcrossed with SS strain Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614 congenic Unknown 5 144865363 168174140 1 - by flanking markers 5 147288554 171686754 1 - by flanking markers 5 143523348 168109659 1 - by flanking markers 5 137790781 161481680 1 - by flanking markers RRID:RGD_728158 728159 SS.LEW-(D1Mco36-D1Rat49)/Jr Inbred Salt-sensitive SS/Jr rats were mated to LEW/NCrlBR rats to create congenic strain. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 124748920 146189942 1 - by flanking markers 1 131958920 160138947 1 - by flanking markers 1 130917121 153834227 1 - by flanking markers 1 123479780 143506731 1 - by flanking markers RRID:RGD_728159 728161 PD/Cub polydactylous Strain a highly inbred strain kept since 1969 at the Institute of Biology Medical Genetics, Charles University, Prague. Strain originated from Wistar rats exhibiting a spontaneous mutation which gave rise to the dolydactyly-luxate syndrome. Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic inbred Unknown RRID:RGD_728161 728162 SS.LEW-(D1Mco87-D1Rat71)/Jr Inbred Salt-sensitive SS/Jr rats were mated to LEW/NCrlBR rats to create congenic strain. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 145648742 206567907 1 - by flanking markers 1 159182062 226102807 1 - by flanking markers 1 152870926 219232156 1 - by flanking markers 1 142990289 201278233 1 - by flanking markers RRID:RGD_728162 728163 SS.LEW-(D1Uia2-D1Rat49)/Jr Inbred Salt-sensitive SS/Jr rats were mated to LEW/NCrl rats to create congenic strain. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 157497884 157498254 1 - by flanking markers 1 171330622 171330794 1 - by flanking markers 1 165129767 165129939 1 - by flanking markers 1 154464069 154464242 1 - by flanking markers RRID:RGD_728163 728165 SS.LEW-(D1Rat196-D1Mco36)/Jr Segment of chr 1 from Lewis which is an in-house colony was introgressed into Dahl salt-sensitive strain which was obtained from Charles River. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 55083934 122992360 1 - by flanking markers 1 59282428 130268180 1 - by flanking markers 1 58354072 129209407 1 - by flanking markers 1 57336763 121834139 1 - by flanking markers RRID:RGD_728165 728166 WKY.SHRSP-(D1Rat112-D1Wox29)/Izm A segment from SHRSP/Izm was transferred on a WKY/Izm background Shimane Medical University, Izumo, Japan congenic Unknown 1 124614679 206574346 1 - by flanking markers 1 131822204 226109267 1 - by flanking markers 1 130779148 219238616 1 - by flanking markers 1 123350408 201284693 1 - by flanking markers RRID:RGD_728166 728167 SS.LEW-(Nos2-D10M11Mit119)/Ayd Strains SS/Jr and LEW were bred for F1 then backcrossed to S to give BC1, this was backcrossed to S to give BC2 and so on till BC5, BC5 was crossed to S to duplicate the recombinant segment Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown Nos2 3185 10 65036884 65072453 1 - by flanking markers 10 65423626 65456957 1 - by flanking markers 10 66188290 66221621 1 - by flanking markers 10 63815308 63851208 1 - by flanking markers RRID:RGD_728167 728168 WOK The inbred Wistar-Ottowa-Karlsburg (WOK) rats were obtained from the Diabetes Research Center, Karlsburg, Germany Diabetes Research Center, Karlsberg, Germany inbred Unknown RRID:RGD_728168 728170 SS.MNS-(Mme-D2Mit14)/Ayd Segments from Milan normotensive rat were inserted in thre homologous region of Dahl salt-sensitive, the Atp1a1 gene was from the S strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown Atp1a1|Mme 2167|3098 2 153031724 197256313 1 - by flanking markers 2 173193501 224018437 1 - by flanking markers 2 153799203 204585731 1 - by flanking markers 2 147686913 189599348 1 - by flanking markers RRID:RGD_728170 728171 LEW-RT11/Rj This coisogenic strain was produced by selecting LEW rats with the RT11 allele. The Center dElevage R. Janvier, France. coisogenic Unknown RRID:RGD_728171 728172 SS.MNS-(D2Mit6-Adh1)/Ayd Segments from Milan normotensive rat were inserted in thre homologous region of Dahl salt-sensitive, the Atp1a1 gene was from MNS Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown Adh1|Agtr1b|Atp1a1 2044|2071|2167 2 77630629 235811584 1 - by flanking markers 2 98037122 262102977 1 - by flanking markers 2 78321410 243562243 1 - by flanking markers 2 76539322 226808892 1 - by flanking markers RRID:RGD_728172 728183 WF/N To N in 1975 from NCI at F18. Developed by J. Furth in 1945 from a commercial Wistar stock, in an attempt to develop a strain with high incidence of leukemia. NIH Autoimmune Rat Model Repository and Development Center inbred Unknown RRID:RGD_728183 728184 SHRSP/A3N To NIH in 1975 from Yamori at F36. SHR was isolated from Wistar Kyoto rats by Okamoto and Aoki in 1963. SHR was later separated into several sublines; the A3 subline was found to have a high incidence of cerebrovascular lesions. (517) NIH Autoimmune Rat Model Repository and Development Center inbred Extinct (as of 2020-04-21) RRID:RGD_728184 728185 N:NIH Developed in 1979/80 from a series involving eight inbred strains of rats (BN/SsN, MAIN, BuF/N, M520/N, WN/N, ACI/N, WKY IN, and F344/N). The resulting colony consists of 60 breeding pairs. A circular pair mating system is used to maintain the colony. Unavailable outbred Extinct RRID:RRRC_00237 728186 LEW/SsN To N 1972 from Silvers at F37. Developed by Lewis from a Wistar stock; to Aptekman and Bogden, 1954, at F20; to Silvers 1958 at F31. NIH Autoimmune Rat Model Repository and Development Center inbred Extinct RRID:RGD_728186 728187 ACI/N-j Strain originated from Curtiss and Dunning 1926 at the Columbia University Institute for Cancer Research. To Heston 1945 at F30, to National Institutes of Health 1950 at F41. Subsequent sublines from Dunning or NIH. NIH Autoimmune Rat Model Repository and Development Center congenic Extinct RRID:RGD_728187 728188 LOU/MN To NIH in 1975 from Bazin. In 1970 Bazin and Beckers started breeding LOU rat ancestors from various stocks kept at Universite Catholique de Louvain (probably of Wis- tar origin); from 28 lines bred in parallel, LOU/M was selected for low immunocytoma incidence and LOU/C for high immunocytoma incidence. NIH Autoimmune Rat Model Repository and Development Center inbred Extinct (as of 2020-09-04) RRID:RGD_728188 728189 SHR/N-di Autosomal recessive congenic strain originated from an inbred transfered to NIH in 1966 at F13 from Okamoto. Okamoto, Kyoto School of Medicine, 1963, from outbred Wistar Kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure; brother-sister mating with contin- ued selection for spontaneous hypertension. NIH Autoimmune Rat Model Repository and Development Center congenic Unknown RRID:RGD_728189 728190 RCS-rdy-c Albino retinal dystrophy This congenic strain is obtained from pink-eyed, tan-hooded RCS rats NIH Autoimmune Rat Model Repository and Development Center congenic Unknown RRID:RGD_728190 728191 LOU/CN To N in 1976 from Bazin at F?. In 1970 Bazin and Beckers started breeding LOU rat ancestors from various stocks kept at Universite Catholique de Louvain (probably of Wis- tar origin); from 28 lines bred in parallel, LOU/C was selected for high immunocytoma incidence and LOU/M for low immunocytoma incidence. (045) NIH Autoimmune Rat Model Repository and Development Center inbred Extinct RRID:RGD_728191 728192 RCS-rdy-p This congenic strain is obtained from pink-eyed, tan-hooded RCS rats. Retinal degeneration starts at about 3 weeks. NIH Autoimmune Rat Model Repository and Development Center congenic Unknown RRID:RGD_728192 728193 N:SD Sprague-Dawley To N 1945 from Sprague Dawley, Inc. Colony closed since then. NIH Autoimmune Rat Model Repository and Development Center, Rat Resource and Research Center outbred Extinct RRID:RRRC_00239 728194 SHR/N To N 1966 at F13 from Okamoto. Okamoto, Kyoto School of Medicine, 1963, from outbred Wistar Kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure; brother-sister mating with contin- ued selection for spontaneous hypertension. NIH Autoimmune Rat Model Repository and Development Center inbred Extinct RRID:RGD_728194 728195 SHR/N-cp The spontaneously hypertensive corpulent (SHR/N-cp) rat developed at the National Institutes of Health (NIH) is a congenic strain in which obese homozygotes {cp/cp) are characterized by genetic obesity, mild hypertension, hyper-insulinemia, and glucose intolerance. This rat strain was initially derived by mating a male Koletsky rat that was heterozygous for the corpulent gene (cp/ +) to a female SHR ratof the Okamoto strain. A minimum of 12 backcrosses were carried out to eliminate the non-cp genes of the Ko-letsky strain. The obese (cp/cp) littermates develop glucosuria, proteinuria, and renal structural lesions resemblingdiabetic glomerulosclerosis. Rat Resource and Research Center congenic Cryopreserved Embryo (as of 2021-01-20) RRID:RRRC_00231 728196 RHA/N-j Heterozygous Gunn rats were mated with RHA/N the heterzygous offsprings of this and each following generation was backcrossed with RHA/N to get these congenics. NIH Autoimmune Rat Model Repository and Development Center congenic Extinct RRID:RGD_728196 728197 RCS-rdy-+ This congenic strain is obtained from pink-eyed, tan-hooded RCS rats NIH Autoimmune Rat Model Repository and Development Center congenic Unknown RRID:RGD_728197 728198 BHE/N Bureau of Home Economics To N in 1979 from Flow Laboratories. Closed colony since then. BHE was started in 1942 by the Agricultural Research Service. USDA from a cross between a black and white hooded strain from Pennsylvania State College and an albino Os- borne-Mendel (also called the Yale strain) strain from Columbia University. NIH Autoimmune Rat Model Repository and Development Center inbred Extinct RRID:RGD_728198 728199 RHA Roman high avoidance Bignami selected for high avoidance conditioning with light as a conditioned stimulus and electric shock as the unconditioned stimulus (Bignami 1965). NIH Autoimmune Rat Model Repository and Development Center congenic Unknown RRID:RGD_728199 728200 ACI/N-di Congenic strain originated from ACI/N inbred strain which came to National Institutes of Health in 1950 at F41. NIH Autoimmune Rat Model Repository and Development Center congenic Unknown RRID:RGD_728200 728358 SB This outbred Sabra strain has been bred in Hebrew University for 60 years.Its breeding scheme and origin is unclear. R. Kalman, Authority for Animal Facilities outbred Unknown RRID:RGD_728358 728383 UPL/Cas Upjohn Pharmaceuticals Limited In 1989 spontaneous cataract was observed in Sprague-Dawley rats at the Upjohn Pharmaceuticals Limited. The progeny of affected female had cataract which was hereditary by brother-sister mating. National BioResource Project for the Rat in Japan inbred Unknown Gja8m1Cas 13524999 RRID:RGD_728383 728384 SS.LEW-(D10Rat24-Igfbp4)/Ayd A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown Igfbp4 2875 10 79229067 87834315 1 - by flanking markers 10 78194957 86759484 1 - by flanking markers 10 78343027 86962563 1 - by flanking markers 10 75631887 84007272 1 - by flanking markers RRID:RGD_728384 728385 WF.COP-(D2Rat2-D2M13Mit286)/Uwm A segment of chromosome 2 was transferred from COP into the WF background. The recombinant congenic strain, line QQ, was derived from three Mcs1-congenic lines at various backcross generations and was produced at the N10 or N12 backcross generations by intercrossing heterozygous brother and sister pairs. University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 2 14747814 14747981 1 - by flanking markers 2 14095321 14095488 1 - by flanking markers 2 14237830 14237997 1 - by flanking markers 2 16491740 16491908 1 - by flanking markers RRID:RGD_728385 728386 SS.LEW-(D10Rat119-D10Rat133)/Ayd A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown 10 53675361 65668639 1 - by flanking markers 10 53273326 64823355 1 - by flanking markers RRID:RGD_728386 728387 WF.COP-(D2Mit29-D2Uwm13)/Uwm A segment of chromosome 2 was transferred from COP into the WF background. The recombinant congenic strain (line Q) was derived from three Mcs1-congenic lines at various backcross generations and was produced at the N10 or N12 backcross generations by intercrossing heterozygous brother and sister pairs. University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 2 5601528 11957973 1 - by flanking markers 2 5396621 11387756 1 - by flanking markers 2 5417336 11522696 1 - by flanking markers 2 7887772 13840758 1 - by flanking markers RRID:RGD_728387 728388 SS.LEW-(D10Rat119-D10Mgh1)/Ayd A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown 10 53675361 53675478 1 - by flanking markers 10 53273326 53273444 1 - by flanking markers RRID:RGD_728388 728389 WF.COP-(D2Mit29-D2Rat201)/Uwm A segment of chromosome 2 was transferred from COP into the WF background. Rats were genotyped using multiple microsatellite markers spanning 20-30 cM of the Mcs1 locus from D2Mit29 to D2Rat201 on the centromeric end of chromosome 2. The strain was produced at the N10 or N12 backcross generations by intercrossing heterozygous brother and sister pairs. University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 2 5601528 49691646 1 - by flanking markers 2 5396621 68633866 1 - by flanking markers 2 5417336 50260392 1 - by flanking markers 2 7887772 49657252 1 - by flanking markers RRID:RGD_728389 728391 WF.COP-(D2Rat253-D2Uwm17)/Uwm A segment of chromosome 2 was transferred from COP into the WF background. The recombinant congenic strain, line K, was derived from three Mcs1-congenic lines at various backcross generations and was produced at the N10 or N12 backcross generations by intercrossing heterozygous brother and sister pairs. University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 2 25663274 32051637 1 - by flanking markers 2 44171519 50382003 1 - by flanking markers 2 25012974 31224929 1 - by flanking markers 2 26559817 32374088 1 - by flanking markers RRID:RGD_728391 728392 RHA/N-di Roman high avoidance-di mutation Brattleboro rats were mated with RHA/N, the heterzygous offsprings of this and each following generation was backcrossed with RHA/N to get these congenics. NIH Autoimmune Rat Model Repository and Development Center congenic Unknown RRID:RGD_728392 728393 SS.LEW-(D10Got125-D10Rat120)/Ayd A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown 10 86983905 92373412 1 - by flanking markers 10 85965754 91041690 1 - by flanking markers 10 86168841 91270722 1 - by flanking markers 10 83212828 88132643 1 - by flanking markers RRID:RGD_728393 728394 SS.LEW-(D10Rat55-D10Rat13)/Ayd A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown 10 89167104 97152587 1 - by flanking markers 10 87933406 95701443 1 - by flanking markers 10 88140923 95967298 1 - by flanking markers 10 85160679 92699242 1 - by flanking markers RRID:RGD_728394 728395 SS.LEW-(D10Rat55-D10Rat120)/Ayd A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown 10 89167104 92373412 1 - by flanking markers 10 87933406 91041690 1 - by flanking markers 10 88140923 91270722 1 - by flanking markers 10 85160679 88132643 1 - by flanking markers RRID:RGD_728395 728396 SS.LEW-(D10Mco15-D10Mgh1)/Ayd A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown 10 98392296 98392508 1 - by flanking markers 10 97028717 97028928 1 - by flanking markers 10 97308358 97308569 1 - by flanking markers 10 93995749 93995963 1 - by flanking markers RRID:RGD_728396 731185 MWF/Fub Munich Wistar Fromter Munich Wistar Fromter rats were obtained from colonies at the Freie Universitat, Benjamin Franklin Campus Berlin, Germany Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany inbred Unknown RRID:RGD_731185 731186 SHR/Fub Spontaneously hypertensive rats were obtained from colonies at the Freie Universit?t, Benjamin Franklin Campus Berlin, Germany Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany inbred Unknown RRID:RGD_731186 731187 Iusm:HAD2 high-alcohol-drinking These were developed by selective breeding for alcohol preference and consumption from the heterogeneous N/N strain. 8 inbred rat strains were intercrossed. Within-family selection and a rotational breeding design were employed to reduce inbreeding and to allow maintenance of non-inbred replicate lines. Replicate lines were independently selected for high alcohol drinking (HAD1 and HAD2). Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana outbred Unknown RRID:RGD_731187 731188 Iusm:LAD2 low-alcohol-drinking These were developed by selective breeding for alcohol preference and consumption from the heterogeneous strain N:NIH (RGD:728185). 8 inbred rat strains were intercrossed.Within-family selection and a rotational breeding design were employed to reduce inbreeding and to allow maintenance of non-inbred replicate lines. Replicate lines were independently selected for low alcohol drinking (LAD1 and LAD2). Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana outbred Unknown RRID:RGD_731188 731189 SHRSP.WKY-(Klk1-D1Rat116)/Izm A segment of RNO1 (~70 cM in size) was transferred from WKY/Izm onto the genetic background of SHRSP/Izm by the speed congenic method. Department of Gene Diagnostics and Therapeutics, International Medical Center of Japan, Toyama, Shinjuku-ku, Tokyo, Japan congenic Unknown RRID:RGD_731189 731190 SS.LEW-(D1Rat211-D1Rat18)/Mco A segment of chr 1 from Lewis which was obtained from Charles was introgressed into Dahl salt-sensitive strain which is an in-house colony. Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown 17;1 1147796;43747374 1148037;43747532 1 - by flanking markers;1 - by flanking markers 1 35077728 50297622 1 - by flanking markers 1 33667777 49454378 1 - by flanking markers 1 31050840 49268520 1 - by flanking markers RRID:RGD_731190 731191 SHRSP.WKY-(D2Rat14-D2Mgh12)/Gcrc A segment of chromosome 2 containing blood pressure QTLs was transferred from WKY into SHRSP. University of Glasgow, Glasgow, UK congenic Unknown 2 210636008 210636169 1 - by flanking markers 2 61825950 235592880 1 - by flanking markers 2 42776916 217498710 1 - by flanking markers 2 42804607 202447032 1 - by flanking markers RRID:RGD_731191 731192 SS.LEW-(D3Rat52-D3Rat130)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D3Rat52-D3Rat17)/Ayd Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 3 14051872 44551542 1 - by flanking markers 3 19410399 55227748 1 - by flanking markers 3 14090411 48562146 1 - by flanking markers 3 18311454 47233430 1 - by flanking markers RRID:RGD_731192 731193 DA.PVG-(D4Rat141-D4Mgh11) PVG allele is introgressed into the DA rats. Recombinant strains were derived from these which were used in further studies. Department of Medicine, Karolinska Institutet, Stockholm, Sweden congenic Unknown 4 151158666 171204531 1 - by flanking markers 4 210231569 230565226 1 - by flanking markers 4 146942075 168047091 1 - by flanking markers 4 148090542 167139601 1 - by flanking markers RRID:RGD_731193 731194 SS.LEW-(D3Chm64-D3Rat17)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D3Rat52-D3Rat17)/Ayd Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 3 52127226 121619110 1 - by flanking markers 3 62850379 133513825 1 - by flanking markers 3 56217734 127023997 1 - by flanking markers 3 54740735 121056321 1 - by flanking markers RRID:RGD_731194 731195 DA.E3-(D14Wox8-D14Rat64)/Rhd The fragment of interest is transferred from arthritis resistant E3 strain to the susceptible DA strain. Medical Inflammation Research, BMC, University of Lund, Lund, Sweden congenic Unknown 14 68573958 68574165 1 - by flanking markers 14 67969510 67969716 1 - by flanking markers 14 67944692 67944898 1 - by flanking markers 14 63618971 63619178 1 - by flanking markers RRID:RGD_731195 734471 SS.LEW-(D1Mgh7-D1Mco41)/Jr This is a congenic substrain derived from SS.LEW-(D1Mco2-D1Mco35)/Jr. A 71 cM fragment of LEW chr 1 was introgressed into SS background. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 106445165 227693454 1 - by flanking markers 1 114600888 249451438 1 - by flanking markers 1 113593576 242177304 1 - by flanking markers 1 106047847 221920075 1 - by flanking markers RRID:RGD_734471 734472 SS.LEW-(D1Mco2-D1Wox6)/Jr This is a congenic substrain derived from SS.LEW-(D1Mco2-D1Mco35)/Jr. A 40 cM fragment of LEW chr 1 was introgressed into SS background. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 131956599 131956825 1 - by flanking markers 1 58687835 138778112 1 - by flanking markers 1 57761120 137787460 1 - by flanking markers 1 56732484 56732668 1 - by flanking markers RRID:RGD_734472 734473 SS.LEW-(D17Mco3-D17Mco10)/Jr SS rats were crossed with LEW and the F1 rats were backcrossed to SS. Heterozygous rats with the chromosomal region of interest were selected and backcrossed for the next generation. This was done for eight generations and then the heterozygous animals were intercrossed. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 17 28967455 70289318 1 - by flanking markers 17 24748228 66699053 1 - by flanking markers 17 22774867 64946465 1 - by flanking markers 17 23080368 59555289 1 - by flanking markers RRID:RGD_734473 734474 SS.LEW-(D5Mit9-D5Mco10)/Jr SS rats were crossed with LEW and the F1 rats were backcrossed to SS. Heterozygous rats with the chromosomal region of interest were selected and backcrossed for the next generation. This was done for eight generations and then the heterozygous animals were intercrossed. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 62555131 168174140 1 - by flanking markers 5 66128197 171686754 1 - by flanking markers 5 61612600 168109659 1 - by flanking markers 5 60293434 161481680 1 - by flanking markers RRID:RGD_734474 734475 DA/OlaHsd Odell at the Oak Ridge National Laboratory (USA) initiated the inbreeding of these rats which was completed at the Wistar Institute (USA) in 1965. Envigo inbred Unknown RRID:RGD_734475 734476 Crl:CD(SD) Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. To CRL in 1950 from Sprague Dawley, Inc. Caesarean rederived in 1955 from original Charles River Sprague Dawley. colonies. In 1991, 8 colonies were selected to form the IGS Foundation Colony. Rederived into isolator foundation colony in 1997. IGS refers to animals bred using the CRL International Genetic Standard system. Charles River Laboratories outbred Unknown RRID:RGD_734476 734478 F344/DuCrl This colony was originated by mating F344 rats which were purchased from local breeder(Fischer) by M.R. Curtis, Columbia University Institute for Cancer Research, 1920. Dunning at Columbia inbred to form the strain starting in 1920. Dunning to CRL in 1960 at F68. Caesarean rederived in 1960. Charles River Laboratories inbred Unknown RRID:RGD_734478 734479 SS.LEW-(D1Mco2-D1Rat49)/Jr This is a congenic substrain derived from SS.LEW-(D1Mco2-D1Mco35)/Jr. A 57 cM fragment of LEW chr 1 was introgressed into SS background. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 157497884 157498254 1 - by flanking markers 1 58687835 171330794 1 - by flanking markers 1 57761120 165129939 1 - by flanking markers 1 56732484 154464242 1 - by flanking markers RRID:RGD_734479 734480 SS.LEW-(D10Mit10-D10Mgh1)/Jr SS rats were crossed with LEW and the F1 rats were backcrossed to SS. Heterozygous rats with the chromosomal region of interest were selected and backcrossed for the next generation. This was done for eight generations and then the heterozygous animals were intercrossed. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 27184741 102587587 1 - by flanking markers 10 27082535 101157704 1 - by flanking markers 10 27237530 101482600 1 - by flanking markers 10 26521957 98003205 1 - by flanking markers RRID:RGD_734480 734481 SS.LEW-(D1Mco2-D1Mco35)/Jr SS rats were crossed with LEW and the F1 rats were backcrossed to SS. Heterozygous rats with the chromosomal region of interest were selected and backcrossed for the next generation. This was done for eight generations and then the heterozygous animals were intercrossed. A 118 cM fragment of LEW chr 1 was introgressed into SS background. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown Sa 3616 1 238358625 238358813 1 - by flanking markers 1 58687835 259930393 1 - by flanking markers 1 57761120 252708858 1 - by flanking markers 1 56732484 231916666 1 - by flanking markers RRID:RGD_734481 734482 SS.LEW-(D1Rat45-D1Mco41)/Jr This is a congenic substrain derived from SS.LEW-(D1Mco2-D1Mco35)/Jr. A 43 cM fragment of LEW chr 1 was introgressed into SS background. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown Sa 3616 1 146189650 227693454 1 - by flanking markers 1 160138797 249451438 1 - by flanking markers 1 153834077 242177304 1 - by flanking markers 1 143506580 221920075 1 - by flanking markers RRID:RGD_734482 734483 SS.LEW-(D1Rat42-D1Wox10)/Jr This is a congenic substrain derived from SS.LEW-(D1Mco2-D1Mco35)/Jr. A 43 cM fragment of LEW chr 1 was introgressed into SS background. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 135418152 220639653 1 - by flanking markers 1 142342107 244066407 1 - by flanking markers 1 141381406 236763528 1 - by flanking markers 1 133587283 214537671 1 - by flanking markers RRID:RGD_734483 734526 OLETF/Got Otsuka Long Evans Tokushima Long Evans Charles River Canada introduced it to Otsuka Pharmaceutical Co. in 1982. This is selectively bred by oral glucose tolerance test of selective brother-sister mating. Otsuka Pharmacuetical Company, 463-10 Kagasuno, Tokushima, Japan inbred Unknown RRID:RGD_734526 734527 OLETF.F344-(D1Rat169-D1Rat459)/Got Female OLETF/Got rats were crossed with F344/DuCrlCrlj rats. The F1 were backcrossed to OLETF to produce the BC1. Selective males from BC1 were backcrossed to OLETF to produce successive congenic generations. Otsuka Pharmacuetical Company, 463-10 Kagasuno, Tokushima, Japan congenic Unknown 1 229876870 267593558 1 - by flanking markers 1 251652807 289700417 1 - by flanking markers 1 244401175 282365384 1 - by flanking markers 1 224054293 260122809 1 - by flanking markers RRID:RGD_734527 734528 OLETF.BN-(D1Rat76-D1Rat459)/Got Female OLETF/Got rats were crossed with male BN rats. The F1 were backcrossed to OLETF to produce the BC1. Selective males from BC1 were backcrossed to OLETF to produce successive congenic generations. Otsuka Pharmacuetical Company, 463-10 Kagasuno, Tokushima, Japan congenic Unknown 1 230411091 267593558 1 - by flanking markers 1 252243728 289700417 1 - by flanking markers 1 244992467 282365384 1 - by flanking markers 1 224569538 260122809 1 - by flanking markers RRID:RGD_734528 734531 OLETF.F344-(D1Rat306-D1Rat461)/Got Female OLETF/Got rats were crossed with F344/DuCrlj rats. The F1 were backcrossed to OLETF to produce the BC1. Selective males from BC1 were backcrossed to OLETF to produce successive congenic generations. Fourth generation backcrossed congenic animals were intercrossed to produce the F2 generation. Otsuka Pharmacuetical Company, 463-10 Kagasuno, Tokushima, Japan congenic Unknown 1 248583506 266234812 1 - by flanking markers 1 268967725 288207792 1 - by flanking markers 1 280850604 280850810 1 - by flanking markers 1 258843780 258843987 1 - by flanking markers RRID:RGD_734531 734758 DA/Ham Dark-agouti Original DA rats purchased from Shizuoka Laboratory Animal Center (Hamamatsu, Japan). Shizuoka Laboratory Animal Center Hamamatsu, Japan inbred Unknown RRID:RGD_734758 734759 SHRSP/Gcrc Spontaneously hypertensive rat, stroke prone SHRSP strain is maintained at the University of Glasgow since December 1991. This colony is the result of the strain specific brother-sister mating of 13 SHRSP (6 males and 7 females of each) that were obtained from Dr D.F. Bohr (Department of Physiology, University of Michigan, Ann Arbor) where they had been maintained as inbred colonies for more than 15 years. Their breeding stocks were originally obtained from NIH University of Glasgow, Western Infirmary, Glasgow, UK inbred Unknown RRID:RGD_734759 734760 WKY/Gcrc Wistar-Kyoto WKY strain is maintained at the University of Glasgow since December 1991. This colony is the result of the strain specific brother-sister mating of 13 WKY (6 males and 7 females of each) that were obtained from Dr D.F. Bohr (Department of Physiology, University of Michigan, Ann Arbor) where they had been maintained as inbred colonies for more than 15 years. Their breeding stocks were originally obtained from NIH University of Glasgow, Western Infirmary, Glasgow, UK inbred Unknown RRID:RGD_734760 734761 WF/Kga Wistar-Furth Obtained from Hiroshima University (Hiroshima, Japan) and maintained by brother-sister matings for more than 90 generations in the laboratory of Dr M. Kitano (Kagoshima University Dental School, Kagoshima, Japan). Kagoshima University Dental School, Kagoshima, Japan inbred Unknown RRID:RGD_734761 737657 LEW.1AV1 Originally derived by Dr. Hans J. Hedrich at Versuchstierzucht, Hannover, Germany by transgressing the MHC of DA/Han rats (AV1) into LEW/Han rats for 16 backcross generations. RT1av1 haplotype is a variant to the standard a- haplotype with the difference residing in the atypical MHC class I region. National Veterinary Institute, Uppsala, Sweden congenic Extinct RRID:RRRC_00201 737658 PVG.1AV1 Piebald-Virol-Glaxo Originally derived by Dr. Hans J. Hendrich at Versuchstierzucht, Hannover, Germany Harlan UK, Blackthorn, Bicester, UK congenic Unknown RRID:RGD_737658 737690 F344/Crli These animals were from Charles River Italia, Calco, LC, Italy Charles River, Calco, Italy inbred Unknown RRID:RGD_737690 737691 BN/Crli These animals were from Charles River Italia, Calco, LC, Italy Charles River Laboratories Italy inbred Unknown RRID:RGD_737691 737703 LEW-Tg(HLA-B*0702,B2M)120-4TrgTg/Tg Lewis from CRL were used as the background strain. This strain was made by pronuclear injection into Lewis embryos. The embryos were coinjected with DNA fragments containing the HLA-B*0702 human gene and the human beta-2-microglobulin gene. Founder 120-4 was selected and carrier animals from this founder were mated and this strain was bred to homozygosity. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2020-07-08) RRID:RRRC_00042 737857 DA.PVG.1AV1-(D4Rat155-D4Rat84) Congenic strain derived from marker assisted selection for PVG.1AV1 chromsome 4 alleles on the DA recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 185398415 185398530 1 - by flanking markers 4 47848402 246313537 1 - by flanking markers 4 48053950 182171018 1 - by flanking markers 4 49524674 180699135 1 - by flanking markers RRID:RGD_737857 737858 DA.PVG.1AV1-(D4Rat155-Spr) Congenic substrain derived from marker assisted selection for PVG.1AV1 chromsome 4 alleles on the DA recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown Spr 3753 4 119365578 119369308 1 - by flanking markers 4 47848402 181496612 1 - by flanking markers 4 48053950 116916073 1 - by flanking markers 4 49524674 117676292 1 - by flanking markers RRID:RGD_737858 737859 DA.PVG.1AV1-(D4Mgh17-D4Rat56) Congenic substrain derived from marker assisted selection for PVG.1AV1 chromsome 4 alleles on the DA recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 116611031 143663540 1 - by flanking markers 4 177782842 204673386 1 - by flanking markers 4 113100978 113247809 1 - by flanking markers 4 114921280 114921417 1 - by flanking markers RRID:RGD_737859 737861 DA.PVG.1AV1-(D4Rat63-D4Rat203) Congenic substrain derived from marker assisted selection for PVG.1AV1 chromsome 4 alleles on the DA recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 156442644 161435775 1 - by flanking markers 4 219683260 224843794 1 - by flanking markers 4 152598827 157826751 1 - by flanking markers 4 153274175 158112799 1 - by flanking markers RRID:RGD_737861 737862 SHRSP.WKY-(D2Rat14-D2Mit5)/Gcrc A segment of chromosome 2 containing blood pressure QTLs was transferred from WKY into SHRSP. University of Glasgow, Glasgow, UK congenic Unknown 2 66680022 66680209 1 - by flanking markers 2 61825950 86560306 1 - by flanking markers 2 42776916 66828236 1 - by flanking markers 2 42804607 66118463 1 - by flanking markers RRID:RGD_737862 737863 SHRSP.WKY-(D2Wox9-D2Mgh12)/Gcrc A segment of chromosome 2 containing blood pressure QTLs was transferred from WKY into SHRSP University of Glasgow, Glasgow, UK congenic Unknown Gstm1 2755 2 141259937 210636169 1 - by flanking markers 2 161271919 235592880 1 - by flanking markers 2 141583337 217498710 1 - by flanking markers 2 136445150 202447032 1 - by flanking markers RRID:RGD_737863 737864 SS.SR-(D13Mit9-D13Mit1)/Jr Congenic strain developed by introgressing SR/Jr renin gene into the SS/Jr strain. J.P.Rapp, Dept. Physiol. & Molecular Med, Medical College of Ohio, P.O. Box 10008, Toledo, OH 43699-0008, USA congenic Unknown 13 25430110 55033994 1 - by flanking markers 13 14281836 63533335 1 - by flanking markers 13 9016742 58537177 1 - by flanking markers 13 5994668 53050594 1 - by flanking markers RRID:RGD_737864 737865 WKY.SHRSP-(D2Rat14-D2Mgh12) A segment of chromosome 2 which includes blood pressure QTLs was transferred from SHRSP into WKY. University of Glasgow, Glasgow, UK congenic Unknown 2 210636008 210636169 1 - by flanking markers 2 61825950 235592880 1 - by flanking markers 2 42776916 217498710 1 - by flanking markers 2 42804607 202447032 1 - by flanking markers RRID:RGD_737865 737866 WKY.SHRSP-(D2Rat14-D2Mit5) A segment of chromosome 2 near blood pressure QTLs was transferred from SHRSP into WKY University of Glasgow, Glasgow, UK congenic Unknown 2 66680022 66680209 1 - by flanking markers 2 61825950 86560306 1 - by flanking markers 2 42776916 66828236 1 - by flanking markers 2 42804607 66118463 1 - by flanking markers RRID:RGD_737866 737867 SS.SR-(D13N1-D13Mit1)/Jr Congenic substrain which has a chromosome 13 segment from congenic SS/Jr.SR/Jr-Ren transferred to the SS/Jr recipient strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 13 25430110 38985930 1 - by flanking markers 13 14281836 48881269 1 - by flanking markers 13 9016742 43785939 1 - by flanking markers 13 5994668 37902821 1 - by flanking markers RRID:RGD_737867 737868 SS.SR-(Syt2-D13Mit1)/Jr Congenic substrain which has a chromosome 13 segment from congenic SS/Jr.SR/Jr-Ren transferred to the SS/Jr recipient strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown Syt2 3804 13 25430110 47699094 1 - by flanking markers 13 14281836 56630530 1 - by flanking markers 13 9016742 51577824 1 - by flanking markers 13 5994668 46197976 1 - by flanking markers RRID:RGD_737868 737869 OLETF.BN-(D1Rat461-D1Rat459)/Got Female OLETF/Got rats were crossed with male BN rats. The fifth generation of congenic animals were used for a Niddm QTL linkage study. Otsuka Pharmacuetical Company, 463-10 Kagasuno, Tokushima, Japan congenic Unknown 1 266234605 267593558 1 - by flanking markers 1 288207586 289700417 1 - by flanking markers 1 280850604 282365384 1 - by flanking markers 1 258843780 260122809 1 - by flanking markers RRID:RGD_737869 737870 DA.E3-(D20Wox3-D20Mgh4)/Rhd A fragment containing MHC region was introduced in DA by marker-assisted breeding and verified as pure congenic line after six generations of backcross to DA. Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown 20 3660646 6880472 1 - by flanking markers 20 6935875 7910747 1 - by flanking markers 20 4855475 5875448 1 - by flanking markers 20 3621656 6691706 1 - by flanking markers RRID:RGD_737870 737871 DA.E3-(D12Got46-D12Rat26)/Rhd This congenic strain was obtained by the conventional backcross breeding to the parental DA strain with the negative selection of all known Pia QTLs and positive selection of microsatellite markers. Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown 12 23362298 23845733 1 - by flanking markers 12 27316608 30964880 1 - by flanking markers 12 25307118 29014362 1 - by flanking markers 12 22297209 22692658 1 - by flanking markers RRID:RGD_737871 737872 DA.E3-(D4Mit16-D4Mgh11)/Rhd This congenic strain was obtained by the conventional backcross breeding to the parental DA strain with the negative selection of all known Pia QTLs and positive selection of microsatellite markers. Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown 4 130228504 171204531 1 - by flanking markers 4 192286223 230565226 1 - by flanking markers 4 127777294 168047091 1 - by flanking markers 4 128289450 167139601 1 - by flanking markers RRID:RGD_737872 737873 DA.E3-(D6Wox5-D6Rat90)/Rhd This congenic strain was obtained by the conventional backcross breeding to the parental DA strain with the negative selection of all known Pia QTLs and positive selection of microsatellite markers. Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown 6 117361909 117362003 1 - by flanking markers 6 126582753 126582846 1 - by flanking markers 6 117355600 117355693 1 - by flanking markers 6 112636280 112636374 1 - by flanking markers RRID:RGD_737873 737885 RHA/Kun Roman high avoidance Roman High Avoidance strain selectively bred for good two-way avoidance acquisition, maintained by Mr. F.G.J. Janssen at Katholieke Universiteit, The Netherlands Dept of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, The Netherlands inbred Unknown RRID:RGD_737885 737886 BDX/Cub Recombinant inbred substrain of BDX, maintained by Faculty of Veterinary Medicine, Utrecht University, The Netherlands Dept of Biology, Charles University, Prague, Czech Republic inbred Unknown RRID:RGD_737886 737887 AO/OlaHsd These rats were obtained from Harlan UK and maintained at the Dept. of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands Envigo inbred Cryorecovery RRID:RGD_737887 737888 LEW/NHsdCpb These rats were obtained from Harlan UK and maintained at the Dept. of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands Harlan Sprague Dawley, Inc., Indianapolis, IN inbred Unknown RRID:RGD_737888 737889 LEW/Ipcv These rats were obtained from Harlan UK and maintained at the Dept. of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands unknown inbred Unknown RRID:RGD_737889 737891 Crl:SD Sprague-Dawley stock initiated by R. Dawley in 1925; To SASCO from ARS/Sprague Dawley in 1979. To Charles River in 1996 now maintained by Charles River Laboratory. Charles River Laboratories, Inc., Wilmington, MA outbred Unknown RRID:RGD_737891 737892 ACI/SegHsd This substrain is derived by Albert Segaloff of the Alton Ochsner Medical Foundation in 1956, now maintained by Harlan Sprague-Dawley, Inc. Envigo inbred Unknown Carcinogenesis; Estrogen-induced pituitary growth; Transplant immunology RRID:RGD_737892 737893 F344/Ztm Substrain of Fischer rats maintained by Dr. H.J. Hedrich, Hannover Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737893 737894 LEW/Orl Substrain of Lewis rats, maintained in Orleans, France Institut de Transgenose, Orleans, France inbred Unknown RRID:RGD_737894 737895 WKY/Ztm Substrain of WKY rats maintained by Dr. H.J. Hedrich, Hannover Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737895 737896 BN/Maas Substrain of BN rats, maintained by Dr. Alex Maas, The Netherlands Erasmus MC, DR Rotterdam, The Netherlands inbred Unknown RRID:RGD_737896 737897 ACI/Kun Substrain of ACl maintained by Mr. F.G.J. Janssen at Katholieke Universiteit, The Netherlands Central Animal Laboratory, Katholieke Universiteit, Nijmegen, The Netherlands inbred Unknown RRID:RGD_737897 737898 WOKA/K Substrain of WOKA, maintained by Dr. H. Bibergeil in Karlsburg, Germany Zentralinstitut fur Diabetes, Division of Laboratory Animal Science, Karlsburg, Germany inbred Unknown RRID:RGD_737898 737899 BN/Cub Recombinant inbred substrain of BN, maintained by Faculty of Veterinary Medicine, Utrecht University, The Netherlands Dept of Biology, Charles University, Prague, Czech Republic inbred Unknown RRID:RGD_737899 737900 WF/Ztm Recombinant inbred substrain of WF, from Utrecht University to Dr. H.J. Hedrich, Hannover, Germany Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737900 737901 LH/Ztu A substrain of LH unknown inbred Unknown RRID:RGD_737901 737902 BDIX/Orl Substrain of BDIX, now maintained in Orleans, France Institut de Transgenose, Orleans, France inbred Unknown RRID:RGD_737902 737903 Hsd:SD Sprague Dawley Originated by the Sprague-Dawley Company in 1925 through a series of crosses begun with a single-hooded male and six albino females of unknown origin. Current Harlan Laboratories' colonies are direct descendants of this original colony. Envigo outbred Unknown RRID:RGD_737903 737904 U/A Substrain of U, from Zootechnical Institute, Utrecht to The Netherlands Cancer Institute The Netherlands Cancer Institute, Amsterdam, The Netherlands inbred Unknown RRID:RGD_737904 737905 LEW/Maas Strain originated from Dr. Margaret Lewis from Wistar stock, to Aptekman and Bogden 1954 at F20, to Silvers in 1958 at F31. Subsequently distributed by Silvers. University of Limburg, Netherlands inbred Unknown RRID:RGD_737905 737906 MWF/Hsd Munich Wistar Fromter Substrain of Munich Wistar stock, inbred by Harlan Sprague Dawley Harlan inbred Unknown (as of 2020-04-03) RRID:RGD_737906 737907 SS.SR-Inha/Jr A chromosome 9 segment that may contain an SR/Jr low blood pressure allele was transferred to the SS/Jr recipient strain J.P. Rapp, Dept Physiology and Molec Med, Medical College of Ohio, USA congenic Unknown RRID:RGD_737907 737908 WF/NHsd Substrain of Wistar Furth stock, inbred by National Institute of Health, Bethesda, MD and now available at Harlan Sprague Dawley. Envigo inbred Cryopreserved Embryo (as of 2022-03-24) RRID:RGD_737908 737909 R/A Substrain of R, from Wistar stock in 1947, to The Netherlands Cancer Institute The Netherlands Cancer Institute, Amsterdam, The Netherlands inbred Unknown RRID:RGD_737909 737910 ARISTORAT/Wsl Substrain of ARISTORAT, from Dr. Herve Bazin in Bruxelles, Belgium Experimental Immunology Unite Faculty of Medicine Clos Chapelle aux Champs, Universite de Louvain, Bruxelles Belgium inbred Unknown RRID:RGD_737910 737911 BUF/Ztm Substrain of BUF, from Heston 1946 from Buffalo stock of H. Morris, to Dr. H.J. Hedrich, Hannover, Germany Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737911 737912 SS/JrIpcv strain originated from Dr. John P. Rapp, Medical College of Ohio, USA Czech Academy of Sciences inbred Unknown RRID:RGD_737912 737913 E3/Ztm Substrain of E3, from Dr. H.J. Hedrich, Hannover, Germany Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737913 737914 SDL/Ipcv Substrain of SDL unknown inbred Unknown RRID:RGD_737914 737915 R/AWa Substrain of R, from Muhlbock from a Wistar stock in 1947, to Leyton in 1986 Dept of Genetics, Agricultural University, Wageningen, The Netherlands inbred Unknown RRID:RGD_737915 737916 DZB/Gro Substrain of DZB, to Dr. G.A. van Oortmerssen at University of Groningen Center for Biology Kerklaan, University of Groningen, The Netherlands inbred Unknown RRID:RGD_737916 737917 WF/Mol Substrain of Wistar Furth stock, from J Furth in 1945 to P Schjodtz, Denmark Mollegaard Breeding Centre Ltd., Denmark inbred Unknown RRID:RGD_737917 737918 BN/Orl Substrain of BN, from Billingham and Silvers 1958, to JP Regnault in Orleans, France Institut de Transgenose, Orleans, France inbred Unknown RRID:RGD_737918 737919 LEW/Han Substrain of LEW, from Dr Margaret Lewis from Wistar stock in early 1950s, to HJ Hedrich, Hannover, Germany Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737919 737920 BH/Ztm Substrain of BH, black-hooded, from D Wilson at U of Penn, to DML at U of Iowa in 1973, to ZTM in 1973 Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737920 737921 BDIV/lfz Substrain of BDIV, from cross between BDI and BDII single mating pair, with selection for coat color alleles (Druckrey 1971) unknown inbred Unknown RRID:RGD_737921 737922 LEW/SsNHsd Inbreeding of the Lewis rat is begun by Dr. Margaret Lewis from a Wistar stock. In 1924, at F20 to Aptekmanm and Bogdon. In 1958, at F31 to Silvers, who distributed this strain. subsequently. LEW/SsNHsd rats were descended from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland USA. Harlan became Envigo in 2015. ENVIGO inbred Unknown RRID:RGD_737922 737923 SHR/Maas Substrain of SHR, spontaneously hypertensive rat, from Okamoto in 1963, to A Maas in The Netherlands Erasmus MC, DR Rotterdam, The Netherlands inbred Unknown RRID:RGD_737923 737924 WAG/Rij Substrain of WAG, from AL Bacharach, Glaxo Ltd from Wistar stock in 1924, from Rij to Kyoto in 1979 Harlan Sprague Dawley, Indianapolis, IN inbred Unknown RRID:RGD_737924 737925 BN/Gro Substrain of BN, from Billingham and Silvers 1958, to U of Groningen Center for Biology Kerklaan, University of Groningen, The Netherlands inbred Unknown RRID:RGD_737925 737926 F344/NCrl Derived from NIH stock in 1992 by SASCO. To Charles River in 1996. Charles River Laboratories inbred Unknown RRID:RGD_737926 737927 ALC/Colle Substrain of ALC unknown inbred Unknown RRID:RGD_737927 737928 BN/NHsdCpb Substrain of BN, from Billingham and Silvers 1958 Harlan CPB, Harlan Sprague Dawley, Inc., Indianapolis, IN inbred Unknown RRID:RGD_737928 737929 Crl:WI Wistar rats To Scientific Products Farm, Ltd. [predecessor of Charles River United Kingdom (CRUK)] in 1947 from Wistar Institute. To Charles River in 1975 from CRUK. This particular colony was selected because of a low incidence of hydronephrosis. Charles River Laboratories outbred Unknown RRID:RGD_737929 737930 LEW/Ztm LEW/Ztm This inbred strain originated from LEW rats housed at the Tierlaboratorium der Medizinischen Hochschule Hannover, Germany Tierlaboratorium der Medizinischen Hochschule Hannover, Germany inbred Unknown Ncf1 61307 RRID:RGD_737930 737931 GC/Kun inbred Unknown RRID:RGD_737931 737932 LEW/Crl Lewis Developed by Dr. Lewis from Wistar stock in the early 1950s. To Charles River from Tulane in 1970 at F34. Charles River Laboratories inbred Unknown RRID:RGD_737932 737933 SD/A Sprague-Dawley stock initiated by R. Dawley in 1925 The Netherlands Cancer Institute, Amsterdam, The Netherlands inbred Unknown RRID:RGD_737933 737934 BN/RijKun Substrain of BN, from Billingham and Silvers 1958, from Harlan Rijnswijk to Central Catholic University Central Animal Laboratory, Katholieke Universiteit, Nijmegen, The Netherlands inbred Unknown RRID:RGD_737934 737935 LEW/Nhg Substrain of LEW, from Dr Margaret Lewis from Wistar stock in early 1950s, to Neuherberg, Germany Gesellschaft fur Strahlen- und Umweltforschung Munchen, Neurerberg, Germany inbred Unknown RRID:RGD_737935 737936 SR/JrIpcv Substrain of SR, from a Sprague-Dawley outbred colony, selected for resistance to salt-induced hypertension (Dahl, 1962) Baylor College of Medicine, Houston, TX inbred Unknown RRID:RGD_737936 737937 SDH/Ztu unknown unknown inbred Unknown RRID:RGD_737937 737938 AUG/OlaHsd Substrain of AUG, derived from US August substrains in 1951 Envigo inbred Cryorecovery RRID:RGD_737938 737939 BBWB/Mol unknown Mollegaard Breeding Centre Ltd., Denmark inbred Unknown RRID:RGD_737939 737940 PAR/Wsl unknown Experimental Immunology Unite Faculty of Medicine Clos Chapelle aux Champs, Universite de Louvain, Bruxelles Belgium inbred Unknown RRID:RGD_737940 737941 LEP/Cub Substrain of LEP, from Charles University cross of outbred animals Dr. Vladimir Kren, Dept of Biology, Charles University, Prague, Czech Republic inbred Unknown RRID:RGD_737941 737942 LE/Ztm Substrain of Long-Evans, from Dr. M Sabourdy in 1960, to Hannover in 1973 Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737942 737943 R/AEurRij Substrain of R, from Muhlbock from a Wistar stock in 1947, to Leyton in 1986 Dr. Adam Goedde, Harlan Rijswijk, Harlan Sprague Dawley, Indianapolis, IN inbred Unknown RRID:RGD_737943 737944 BN/RijN Substrain of BN, from Billingham and Silvers 1958, from Harlan Rijnswijk Harlan Rijswijk, Harlan Sprague Dawley, Indianapolis, IN inbred Extinct RRID:RGD_737944 737945 BN/Han Substrain of BN, from Billingham and Silvers 1958, from Harlan Rijnswijk to Dr. H.J. Hedrich, Hannover, Germany in 1973. Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737945 737946 WAG/OlaHsd Substrain of WAG, from AL Bacharach, Glaxo Ltd from Wistar stock in 1924, maintained at Harlan Sprague Dawley Harlan Sprague Dawley, Inc., Indianapolis, IN inbred Unknown RRID:RGD_737946 737947 BDII/Ztm Substrain of BDII, from cross between BDI and outbred Wistar stock to form single mating pair, with selection for coat color alleles (Druckrey 1971) Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737947 737948 BDE/Ztm Substrain of BDE, resulting from a cross between BDIV and E3, and selected for black hood coat color. Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737948 737949 A2/Colle unknown Dr. RL Collins, The Jackson Laboratory, Bar Harbor, ME inbred Unknown RRID:RGD_737949 737950 DA/Ztm Substrain of DA/OlaHsd, to Hannover after 1965 Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737950 737951 CAP/Kuv unknown Dr. HU Wottge, Universitat Kiel, Kiel, Germany inbred Unknown RRID:RGD_737951 737952 ACI/Ztm unknown Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737952 737953 LEW/Gut Substrain of LEW, from Dr Margaret Lewis from Wistar stock in early 1950s, to Dr. H.J. Hedrich, Hannover, Germany unknown source inbred Unknown RRID:RGD_737953 737954 AS/Ztm unknown Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737954 737955 Hooded/Colle unknown Dr. RL Collins, The Jackson Laboratory, Bar Harbor, ME inbred Unknown RRID:RGD_737955 737956 WF/Gut substrain of Wistar Furth stock, from J Furth in 1945 unknown inbred Unknown RRID:RGD_737956 737957 WOKW/K Substrain of WOKW (originally designated WOK.W1), from outbred Wistar BB rats by brother x sister mating, selected for homozygosity for RT1U, a haplotype which predisposes to type I diabetes, to Karlsburg after 1991 Zentralinstitut fur Diabetes, Division of Laboratory Animal Science, Karlsburg, Germany; National BioResource Project for the Rat in Japan inbred Unknown Diabetes Obesity; Metabolism RRID:RGD_737957 737958 CHOC/Cub unknown Institute of Physiology, Czech Academy of Sciences, Charles University, Prague inbred Unknown RRID:RGD_737958 737959 RNU/Mol unknown Mollegaard Breeding Centre Ltd., Denmark inbred Unknown RRID:RGD_737959 737960 Hsd:WI Wistar These are descendants of rats from the Wistar Institute, Philadelphia, Pennsylvania that are now available from Harlan. Envigo outbred Unknown RRID:RGD_737960 737961 SR/JrMol Substrain of SR, from a Sprague-Dawley outbred colony, selected for resistance to salt-induced hypertension (Dahl, 1962), from Medical College of Ohio to Mollegaard Mollegaard Breeding Centre Ltd., Denmark inbred Unknown RRID:RGD_737961 737962 SPRD/Ztm Substrain of SPRD, from outbred Sprague-Dawley rats at the Hannover facility, where inbreeding began in 1976 Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737962 737963 LEW/Cub Substrain of LEW, from Dr Margaret Lewis from Wistar stock in early 1950s, to Charles University in Prague Institute of Physiology, Czech Academy of Sciences, Charles University, Prague inbred Unknown RRID:RGD_737963 737964 BN/OlaHsd Substrain of BN, from Billingham and Silvers 1958, from Harlan Rijnswijk to Harlan UK and back to Indianapolis Harlan inbred Unknown RRID:RGD_737964 737965 AGUS/OlaHsd Substrain of AGUS, germ-free strain selected by hysterectomy derivation, to Harlan Sprague Dawley after 1968 Harlan inbred Unknown RRID:RGD_737965 737966 LEW/Kuv Substrain of LEW, from Dr Margaret Lewis from Wistar stock in early 1950s, to Kiel University in Germany Universitat Kiel, Kiel, Germany inbred Unknown RRID:RGD_737966 737967 BS/Ztm Substrain of BS, developed at U of Otago Medical School from a cross of wild rats x Wistar (Zeiss 1966), to Hannover after it was inbred in 1988 Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_737967 737968 BN/Gut Substrain of BN, from Billingham and Silvers 1958 unknown inbred Unknown RRID:RGD_737968 737969 NAR/SaU non-albumin rat Substrain of NAR, non-albumin rat, from the National Bio Resource Project in Japan to Utrecht Dept of Laboratory Animal Science, University of Utrecht, The Netherlands inbred Unknown RRID:RGD_737969 737970 AMORAT/Wsl unknown Experimental Immunology Unite Faculty of Medicine Clos Chapelle aux Champs, Universite de Louvain, Bruxelles, Belgium inbred Unknown RRID:RGD_737970 737971 SHRSP/Rivm unknown National Institute of Public Health and Environmental Protection, The Netherlands inbred Unknown RRID:RGD_737971 737972 BN/Crl Silvers and Billingham began brother x sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King and Aptekman in a pen-bred colony of rats trapped from the wild in 1930 by King at the Wistar Institute. To Charles River from Radiobiology Institute, Netherlands in 1976. Charles River Laboratories inbred Unknown RRID:RGD_737972 738038 HEP high ethanol preferring High ethanol preferring strain HEP from generations S6 and S7 of selection were obtained from Robert D. Myers, East Carolina University at Greenville, North Carolina, USA Institut Francois Magendie, rue Camille Saint-Saens, Bordeaux Cedex, France inbred Unknown RRID:RGD_738038 738120 LEW-Tg(HLA-B*2705m1,B2M)133-1TrgTg/Tg This strain was made by pronuclear injection into Lewis embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene (human HLA-B27 gene with Serine replacing Cys67) and the human beta-2-microglobulin gene. Founder 133-1 was selected and carrier animals from this founder were mated and bred to homozygosity. The strain was transferred from Dr. Joel Taurog, University of Texas Southwestern Medical School in Dallas to the Rat Resource and Research Center in 2002. The strain has been maintained by sibling mating. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-11-20) RRID:RRRC_00043 738122 SD-Tg(UBC-EGFP)1BalRrrc This transgenic strain contains the enhanced green fluorescent protein gene under the control of the human ubiquitin-C promoter with a the woodchuck hepatitis virus posttranscriptional regulatory element (WRE). This transgenic strain was made by injecting the lentivirus vector containing the GFP construct (vector name FUGW) into SD rat embryos. Animals that exhibited fluorescence of tails where then mated. The colony was transferred from Carlos Lois, California Institute of Technology, Pasedena, California to the Rat Resource and Research Center in 2002. This strain has been maintained by inter-breeding of carrier animals. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-07-10) RRID:RRRC_00052 1298093 LEW/NHsd Descended from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland. Maintained at Harlan-Sprague Dawley (Indianapolis, Indiana) . Envigo inbred Unknown RRID:RGD_1298093 1299868 SS.SR-(D7Uia1-D7Mco7)/Jr Congenic substrain derived by crossing the congenic strain SS.SR-Cyp11b1/Jr to SS/Jr to isolate which contains a smaller SR/Jr derived chromosome 7 segment Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 7 108875615 113014423 1 - by flanking markers 7 112367543 116100169 1 - by flanking markers 7 112429186 112429483 1 - by flanking markers 7 103146217 103146515 1 - by flanking markers RRID:RGD_1299868 1299869 SS.SR-(Cyp11b1)/Jr Congenic strain which has a SR/Jr chromosome 7 segment containing Cyp11b1 transferred to the SS/Jr recipient strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown RRID:RGD_1299869 1299870 SS.LEW-(D5Uia8-D5Rat108)/Jr SS.LEW-(D5Rat130-D5Rat108)/Jr was selectively backcrossed with the SS strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 121964356 134872385 1 - by flanking markers 5 124025017 137108002 1 - by flanking markers 5 133313668 133313852 1 - by flanking markers 5 128033842 128034027 1 - by flanking markers RRID:RGD_1299870 1299871 DA.F344-(D20Arb2-D20Arb8)/Arb Region of interest was introgressed from F344/Hsd into DA/BklArb by eight to ten genotype guided backcrosses followed by minimum five intercrosses. The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown 20 2790511 2811567 1 - by flanking markers 20 5249981 5270235 1 - by flanking markers 20 3151815 3172069 1 - by flanking markers 20 2646395 2666654 1 - by flanking markers RRID:RGD_1299871 1299872 DA.F344-(D8Arb15-D8Arb22)/Arb Region of interest was introgressed from F344/Hsd into DA/BklArb by eight to ten genotype guided backcrosses followed by minimum five intercrosses. The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown 8 71843628 124310337 1 - by flanking markers 8 77653284 127239929 1 - by flanking markers 8 73320439 128033168 1 - by flanking markers 8 68133439 119085047 1 - by flanking markers RRID:RGD_1299872 1299873 SS.LEW-(D5Mco34-D5Rat108)/Jr SS.LEW-(D5Rat130-D5Rat108)/Jr was selectively backcrossed with the SS strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 134871897 134872385 1 - by flanking markers 5 137107818 137108002 1 - by flanking markers 5 133313668 133313852 1 - by flanking markers 5 128033842 128034027 1 - by flanking markers RRID:RGD_1299873 1299874 OLETF.F344-(D1Rat166-D1Rat90)/Tj Female OLETF were crossed with male F344 rats. The male F1 progeny were backcrossed with female F344 to produce the BC1. Five generations of backcross matings were made between selective males from the BC1 and F344 females to produce the new congenic strain. Sucessive generations were maintained by a standard brother-sister mating protocol. Laboratory of Animal Breeding and Genetics, Kyoto University, Kyoto, Japan National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 1 255026793 267111153 1 - by flanking markers 1 276721459 289137268 1 - by flanking markers 1 269279863 281795785 1 - by flanking markers 1 248393012 259647894 1 - by flanking markers RRID:RGD_1299874 1299875 DA.F344-(D7Rat22-D7Mit2)/Nsi Congenic strain created by backcrossing F344/NHsd into DA/BklArbNsi 9 times then brother-sister mating to maintain in the homozygous state The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-19) arthritis/autoimmunity studies 7 76615341 123191874 1 - by flanking markers 7 125794079 125794357 1 - by flanking markers 7 126080176 126080454 1 - by flanking markers 7 116294265 116294546 1 - by flanking markers RRID:RRRC_00679 1299876 SS.LEW-(D5Rat54-D5Rat108)/Jr SS.LEW-(D5Rat130-D5Rat108)/Jr was selectively backcrossed with the SS strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 126386030 134872385 1 - by flanking markers 5 128816449 137108002 1 - by flanking markers 5 124957483 133313852 1 - by flanking markers 5 120182440 128034027 1 - by flanking markers RRID:RGD_1299876 1299877 DA.F344-(D10Rat204-D10Arb22)/Arb Region of interest was introgressed from F344/Hsd into DA/BklArb by eight to ten genotype guided backcrosses followed by minimum five intercrosses. The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown 10 95695076 95695218 1 - by flanking markers 10 94240348 107484761 1 - by flanking markers 10 107857524 107857673 1 - by flanking markers 10 104060133 104060283 1 - by flanking markers RRID:RGD_1299877 1299878 DA.F344-(D4Arb30-D4Arb4)/Arb The DA/BklArbN strain came from Bantin & Kingman and the F344/NHsd strain came from Harlan Sprague Dawley The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown 4 73972453 154937227 1 - by flanking markers 4 216606296 216606455 1 - by flanking markers 4 150682435 150682594 1 - by flanking markers 4 151805502 151805662 1 - by flanking markers RRID:RGD_1299878 1299879 SS.SR-(D7Mco7-D7Wox19)/Jr Congenic substrain derived by crossing the congenic strain SS.SR-Cyp11b1/Jr to SS/Jr to isolate which contains a smaller SR/Jr derived chromosome 7 segment Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 7 113044000 113044249 1 - by flanking markers 7 116151764 116152012 1 - by flanking markers 7 116249395 116249643 1 - by flanking markers 7 106839225 106839474 1 - by flanking markers RRID:RGD_1299879 1299880 F344.DA-(D20Arb2-D20Arb8)/Arb Region of interest was introgressed from DA/BklArb into F344/Hsd by eight to ten genotype guided backcrosses followed by minimum five intercrosses. The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown 20 2790511 2811567 1 - by flanking markers 20 5249981 5270235 1 - by flanking markers 20 3151815 3172069 1 - by flanking markers 20 2646395 2666654 1 - by flanking markers RRID:RGD_1299880 1299881 SS.LEW-(D5Wox3-D5Rat108)/Jr SS.LEW-(D5Rat130-D5Rat108)/Jr was selectively backcrossed with the SS strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 99080786 134872385 1 - by flanking markers 5 101964092 137108002 1 - by flanking markers 5 97921932 133313852 1 - by flanking markers 5 94858972 128034027 1 - by flanking markers RRID:RGD_1299881 1300432 HAA/FDSC Hatano High Avoidance In 1985 two lines of Sprague-Dawley were selectively bred for their active shuttle-box avoidance task which is a device used for evaluating the effects of chemicals in pharmacological and toxicological studies and testing learning behavior of animals. These animals have a higher rate of avoidance response and showed little interindividual variation. Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan, National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Behavior RRID:RGD_1300432 1300433 LAA/FDSC Hatano Low Avoidance In 1985 two lines of Sprague-Dawley were selectively bred for their active shuttle-box avoidance task which is a device used for evaluating the effects of chemicals in pharmacological and toxicological studies and testing learning behavior of animals. These animals have a lower rate of avoidance response and showed little interindividual variation. Hatano Reserch Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan, National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Behavior RRID:RGD_1300433 1300439 SD-Tg(UBC-EGFP)2BalRrrc This transgenic strain contains the enhanced green fluorescent protein gene under the control of the human ubiquitin-C promoter with a the woodchuck hepatitis virus posttranscriptional regulatory element (WRE). This transgenic strain was made by injecting the lentivirus vector containing the GFP construct (vector name FUGW) into SD rat embryos. Animals that exhibited fluorescence of tails where then mated. The colony was transferred from Carlos Lois, California Institute of Technology, Pasedena, California to the Rat Resource and Research Center in 2002. This strain has been maintained by backcrossing carrier males to SD stock females in order to segregate transgenes and maintain the SD background. The strain now carries a single transgene which is located at chromosome 14q21. Rat Resource and Research Center transgenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-07-10) RRID:RRRC_00065 1302359 HsdFcen:SD These animals were originally bought from Harlan, Indianapolis, USA are have been bred at Bioterio Central since then. Bioterio Central, Ciudad Universitaria, Costanera Norte Ciudad Aut?noma de Buenos Aires Buenos Aires, Argentina outbred Unknown RRID:RGD_1302359 1302360 W/HsdFcen These animals were originally bought from Harlan, Indianapolis, USA are have been bred at Bioterio Central since then. Bioterio Central, Ciudad Universitaria, Costanera Norte Ciudad Aut?noma de Buenos Aires Buenos Aires, Argentina outbred Unknown RRID:RGD_1302360 1302372 SDDIO/Rrrc This strain was made by inbreeding SD rats selected for an obese phenotype when fed a high fat diet. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00044 1302373 SDDR/Rrrc This strain was made by inbreeding SD rats selected for a lean phenotype when fed a high fat diet. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00045 1302377 SPRD-Anks6PKD/Rrrc From outbred Han:SPRD (Sprague-Dawley rats) from Zentralinstitut furVersuchstierkunde, Hannover. This strains carries the Pkdr1 (Anks6) mutation that causes autosomal dominant polycystic kidney disease. The strain was transferred from Dr. Jared Grantham, University of Kansas Medical Center to the Rat Resource and Research Center in 2002. Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-03-07) Anks6PKD 11534996 5 63633540 63674953 1 - by flanking markers 5 67163440 67204853 1 - by flanking markers 5 62642974 62684387 1 - by flanking markers 5 61309183 61350596 1 - by flanking markers RRID:RRRC_00046 1302416 ACI.DA-(D10Rat2-D10Rat19)/Arb A fragment from DA/OlaHsd rats is transferred to ACI/SegHsd. Center for Genomics and Human Genetics, Manhasset, New York congenic Unknown RRID:RGD_1302416 1302597 LEXF7C/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cancer RRID:RGD_1302597 1302598 FXLE26/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Live Animals; Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302598 1302599 WKY/Ta This strain originated from Takeda Chemical Industries, Ltd., Japan National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1302599 1302600 HTX/Kyo hydrocephalus texas 1981 by Kohn from institutional albino rats of unknown origin at University of Texas. From Juntendo University to Kyoto University in 1992. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Neurobiology RRID:RGD_1302600 1302601 FXLE23/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302601 1302602 FXLE12/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302602 1302603 FXLE25/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302603 1302604 LEXF4/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302604 1302605 LEXF2A/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Live Animals Diabetes Obesity; Cancer RRID:RGD_1302605 1302606 SHRSP/Ta This strain originated from Takeda Chemical Industries, Ltd., Japan National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension RRID:RGD_1302606 1302607 FXLE21/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302607 1302608 CXH6/Tj Strain originated from the Institute for Animal Experimentation, University of Tokushima, Tokushima, Japan National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Metabolism; Immunology RRID:RGD_1302608 1302610 KMI/Tky miniature rat ishikawa Miniature Rat Ishikawa derived from a breeding colony of Wistar rats at the Ishikawa Animal Laboratory (Saitama). Introduced to Tokyo Medical College. National BioResource Project for the Rat in Japan segregating_inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Osteosis Prkg2 3401 RRID:RGD_1302610 1302611 FXLE24/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302611 1302612 LEXF10C/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302612 1302613 BN/fMaiHok Kyoto University (Kyo)to Aichi Colony Institute (Idn)to Hokkaido University, Laboratory of Experimental Animal Science(Hok) 1976, F7 to Hokkaido University, Center for Experimental Plants & Animals(Hok) 1982,F21 National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo RRID:RGD_1302613 1302614 WKY/NMna Inbred strain originated at Fujita Health University School of Medicine, Japan from a WKY/N strain. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1302614 1302615 FXLE14/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302615 1302616 LEXF10B/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302616 1302617 LEXF6B/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cancer RRID:RGD_1302617 1302618 LEXF9/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Live Animals; Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302618 1302619 FXLE16/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Live Animals Diabetes Obesity; Cancer RRID:RGD_1302619 1302620 SHR/Kyo spontaneous hypertension rat Okamoto 1963 from outbred Wistar Kyoto rats. Bred from a male with mild hypertension, mated with a female with high blood pressure. Brother x sister mating with continued selection for high blood pressure (Okamoto 1969, Okamoto et al 1972). National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2021-11-12) Cardio Hypertension RRID:RGD_1302620 1302621 LEXF10A/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302621 1302622 WF/Kop Inbred originated from Kagoshima University, Japan. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Cancer RRID:RGD_1302622 1302623 TM/Kyo tester moriyama rat Tester Moriyama rat derived from Long-Evans at Aichi Cancer Center, were transferred to Moriyama Mental Disease Hospital and Nagoya University. Inbred Line was established at Nagoya University. From Shionogi & Co., Ltd. to Kyo in 1976 . National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Hematology Rab38ru 1600311 1 144783919 144864573 1 - by flanking markers 1 158385888 158466621 1 - by flanking markers 1 152072716 152153449 1 - by flanking markers 1 142182566 142262923 1 - by flanking markers RRID:RGD_1302623 1302624 RICO/Ngs Strain originated at Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, Japan. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension; Ophthalmology RRID:RGD_1302624 1302625 F344.OLETF-(D16Wox4-D16Rat13)/Tj Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.37.4 cM segment of the OLETF genome was transferred. National BioResource Project for the Rat in Japan congenic Unknown 16 51452966 77968799 1 - by flanking markers 16 51050772 77759249 1 - by flanking markers 16 51339600 78172206 1 - by flanking markers 16 48143982 73187298 1 - by flanking markers RRID:RGD_1302625 1302626 BN.UPL-(D2Rat134-D2Rat2)/Cas Strain originated from Hiroshima University, Japan National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Ophthalmology 2 14747814 190963154 1 - by flanking markers 2 14095321 217785884 1 - by flanking markers 2 14237830 198298901 1 - by flanking markers 2 16491740 183719262 1 - by flanking markers RRID:RGD_1302626 1302627 F344/NSlc Strain originated from Japan SLC, Inc, Shizuoka, Japan. National BioResource Project for the Rat in Japan inbred Live Animals RRID:RGD_1302627 1302628 ACIS/Hok Spontaneous mutation from ACI/Hok in 1981. National BioResource Project for the Rat in Japan coisogenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1302628 1302629 WKY.SHRSP-(D1Rat49-D1Rat112)/Izm The desired fragment is transferred from SHRSP to WKY. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302629 1302630 F344.OLETF-(D10Wox7-D10Wox6)/Tj Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 10 103550924 103551039 1 - by flanking markers 10 102101261 102101375 1 - by flanking markers 10 102427604 102427718 1 - by flanking markers 10 98952626 98952741 1 - by flanking markers RRID:RGD_1302630 1302631 BN/SsNSlc Strain originated from Japan SLC, Inc, Shizuoka, Japan. National BioResource Project for the Rat in Japan inbred Cryopreserved Sperm Immunology RRID:RGD_1302631 1302632 WKY.SHRSP-(D1Smu11-D1Arb21)/Izm The desired fragment is transferred from SHRSP to WKY. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302632 1302633 FXLE20/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302633 1302634 BB/WorTky BioBreeding rat Mutation causing diabetes mellitus in a closed colony of outbred Wistar rats at Bio-Breeding Labs, Ontario, Canada in 1974 (Chappel and Chappel 1983). To Worcester in 1977 where inbreeding began. Introduced to Tokyo Medical College in 1983. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo Diabetes Obesity; Immunology RRID:RGD_1302634 1302635 F344.OLETF-(D12Rat8-D12Rat16)/Tj Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.37.4 cM segment of the OLETF genome was transferred. National BioResource Project for the Rat in Japan congenic Unknown 12 23934730 31489223 1 - by flanking markers 12 27805580 36160041 1 - by flanking markers 12 25799119 34265075 1 - by flanking markers 12 22779459 30427275 1 - by flanking markers RRID:RGD_1302635 1302636 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm This congenic strain contains an SHRSP/Izm chromsome 1 segment containing a blood pressure QTL transferred to a WKY/Izm background National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 124614679 187092492 1 - by flanking markers 1 131822204 206277202 1 - by flanking markers 1 130779148 199254774 1 - by flanking markers 1 123350408 182418476 1 - by flanking markers RRID:RGD_1302636 1302637 LAA Hatano Low Avoidance Strain originated from Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan Hatano Reserch Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan inbred Unknown RRID:RGD_1302637 1302638 LEXF11/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302638 1302639 KHR/Kyo kaken hairless rat Kaken hairless rat were detected by Kimura from Gunn National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Dermatology Oca2 2318412 1 115683593 115991040 1 - by flanking markers 1 114661970 114987433 1 - by flanking markers 1 107116278 107446093 1 - by flanking markers RRID:RGD_1302639 1302640 ACI/Tj Strain originated from The University of Tokushima, Tokushima, Japan. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo RRID:RGD_1302640 1302641 LEXF1A/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302641 1302642 LEA/Hkm Strain originated at the University of Tokushima, Japan. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo RRID:RGD_1302642 1302643 ACI/NKyo august copenhagen irish NIH (1988, F143) > Kyo (F43) National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Reproduction RRID:RGD_1302643 1302644 CXA5/Tj Strain originated at the University of Tokushima, Japan. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Metabolism; Immunology RRID:RGD_1302644 1302645 DMY/Kyo demyelination rat From a closed but not inbred colony of Sprague Dawley (SD) rats in the laboratory animal facilities of the Universitat Autonoma de Barcelona (Bellaterra Campus) in 1991. Via Institute Pasteur, Paris, to Kyoto University (1996). National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Neurobiology Mrs2dmyKyo 12793071 17 47124915 47142840 1 - by flanking markers 17 43932146 43951399 1 - by flanking markers 17 42064271 42083602 1 - by flanking markers 17 40063924 40087073 1 - by flanking markers RRID:RGD_1302645 1302646 LEXF2C/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302646 1302647 F344.OLETF-(D5Rat166-D5Rat90)/Tj Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.37.4 cM segment of the OLETF genome was transferred. Laboratory of Animal Breeding and Genetics, Kyoto University, Sakyoku, Kyoto, Japan congenic Unknown 5 137718909 139664499 1 - by flanking markers 5 140063670 141938308 1 - by flanking markers 5 136271682 138128882 1 - by flanking markers 5 130881210 132691399 1 - by flanking markers RRID:RGD_1302647 1302648 LEC/Hok Long Evans Cinnamon At the Center for Experimental Plants and Animals, Hokkaido University, LEC, along with LEA, was established from a closed colony of Long-Evans rats obtained from Kobe University in 1975. In 1984, within the LEC rats of their F24 generation, a rat exhibiting spontaneous hepatitis with severe jaundice was found (Yoshida, 1987). The LEC was available from Charles River Japan, Inc., Kanagawa, as of spring, 1991. National BioResource Project for the Rat in Japan mutant Unknown (as of 2016-12-01) Cancer; Immunology Atp7bhts 11532742 16 74607988 74680080 1 - by flanking markers 16 74495179 74575822 1 - by flanking markers 16 74865516 74944935 1 - by flanking markers 16 69952286 70024404 1 - by flanking markers RRID:RGD_1302648 1302649 LEXF7B/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cancer RRID:RGD_1302649 1302650 F344.OLETF-(D9Mgh8-D9Rat15)/Tj Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.37.4 cM segment of the OLETF genome was transferred. National BioResource Project for the Rat in Japan congenic Unknown 9 33374546 62634991 1 - by flanking markers 9 40808491 71887966 1 - by flanking markers 9 41139089 70686886 1 - by flanking markers 9 36840385 65383934 1 - by flanking markers RRID:RGD_1302650 1302651 CXA1/Tj Strain originated from the The University of Tokushima, Japan. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Metabolism; Immunology RRID:RGD_1302651 1302652 LEXF7A/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302652 1302653 LEXF8A/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302653 1302654 F344.OLETF-(D7Mgh16-D7Mgh20)/Tj Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.26.6 cM segment of the OLETF genome was transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 103612739 123191874 1 - by flanking markers 7 106942155 125794357 1 - by flanking markers 7 106995385 126080454 1 - by flanking markers 7 98011396 116294546 1 - by flanking markers RRID:RGD_1302654 1302655 TO/Hkm Strain originated from the Graduate School of Medicine, Hokkaido University, Japan. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo RRID:RGD_1302655 1302656 LEA/Hok Long Evans Agouti Long Evans Agouti derived originally from an outbred Long Evans stock at Hokkaido University and selected for agouti coat colour . It is used as the control strain of the LEC rat, which is reported to exhibit several mutant phenotypes such as hepatic disorder (hts), blockage of the T cell differentiation (thid) and X-ray hypersensitivity (xhs1 and xhs2). National BioResource Project for the Rat in Japan inbred Unknown (as of 2016-12-01) RRID:RGD_1302656 1302657 DOP/Nem dilute-opisthotonus (dop) Founded from a breeding colony of Wistar by Ohno at Yagi Memorial Park in 1988. A congenic line BN-dop and an inbred line DOP-dop were established. National BioResource Project for the Rat in Japan segregating_inbred Cryopreserved Embryo; Cryopreserved Sperm Neurobiology Myo5a 3143 RRID:RGD_1302657 1302658 LEJ/Hkm Strain originated at the Graduate School of Medicine, Hokkaido University, Japan. National BioResource Project for the Rat in Japan inbred Live Animals RRID:RGD_1302658 1302659 CXH5/Tj Strain originated at the University of Tokushima, Japan. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Metabolism; Immunology RRID:RGD_1302659 1302660 RCS/Kyo royal college of surgeons rat From Department of Ophthalmology & Visual Sciences, Kyoto University to Institute of Laboratory Animals (Kyo) in 1998. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Ophthalmology Mertkrdy 40902839 3 116308387 116416414 1 - by flanking markers 3 128669534 128777078 1 - by flanking markers 3 121235230 121340932 1 - by flanking markers 3 115939351 116045141 1 - by flanking markers RRID:RGD_1302660 1302661 F344.OLETF-(D14Rat23-D14Rat12)/Tj Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.29.5 cM segment from the centromere of chr 14 of the OLETF genome was transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 1764386 41707592 1 - by flanking markers 14 2222207 61886417 1 - by flanking markers 14 2227825 61783215 1 - by flanking markers 14 1217606 39153750 1 - by flanking markers RRID:RGD_1302661 1302662 CXH2/Tj Strain originated at the University of Tokushima, Japan. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Metabolism; Immunology RRID:RGD_1302662 1302663 F344.OLETF-(D11Rat4-D11Rat1)/Tj Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.37.4 cM segment of the OLETF genome was transferred. National BioResource Project for the Rat in Japan congenic Unknown 11 64573222 84443333 1 - by flanking markers 11 66731054 89693367 1 - by flanking markers 11 65352097 86593596 1 - by flanking markers 11 62790342 82450994 1 - by flanking markers RRID:RGD_1302663 1302664 WNA/Nshm Nagoya University, Agriculuture to Nagoya University, Medicine 1986 to Nagoya University, Institute of Laboratory Animal Research National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1302664 1302665 FXLE13/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cancer RRID:RGD_1302665 1302666 LEXF1C/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cancer RRID:RGD_1302666 1302667 F344.OLETF-(D5Mgh5-D5Mgh23)/Tj Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.37.4 cM segment of the OLETF genome was transferred. National BioResource Project for the Rat in Japan congenic Unknown 5 45499364 115361927 1 - by flanking markers 5 49028773 117961491 1 - by flanking markers 5 44404276 114014945 1 - by flanking markers 5 43726656 109897936 1 - by flanking markers RRID:RGD_1302667 1302668 IS-Tlk/Kyo tail anomaly lethal kyoto Spontaneous mutation was found in IS/Kyo inbred (F10) at Kyoto University in 1988. Tlk(Tail anomaly Lethal Kyoto) National BioResource Project for the Rat in Japan coisogenic Cryopreserved Embryo; Cryopreserved Sperm Osteosis RRID:RGD_1302668 1302669 HAA Hatano High Avoidance Strain originated at the Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan. Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan inbred Unknown RRID:RGD_1302669 1302670 ACI/NSlc Strain is from Japan SLC, Inc., Shizuoka, Japan. National BioResource Project for the Rat in Japan inbred Live Animals RRID:RGD_1302670 1302671 WM/Tj Strain is from the University of Tokushima, Japan. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1302671 1302672 W/Kyo Hok>Hkm>Kyo National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1302672 1302673 FXLE15/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302673 1302674 VF/Kyo vacuole formation rat The vacuole formation (VF) rat is an autosomal recessive myelin mutant characterized by generalized tremor, hypomyelination, and periaxonal vacuole formation of the central nervous system (CNS). A nonsense mutation in the dopey family member 1 (Dopey1) was identified as the likely causative gene for the neurological disease phenotype of the VF rat. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2020-11-10) Neurobiology RRID:RGD_1302674 1302675 WKY.SHRSP-(D1Smu13-D1Smu11)/Izm The desired fragment is transferred from SHRSP to WKY. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302675 1302676 NER/Slc noda epileptic rat Strain is from Japan SLC, Inc. Shizuoka, Japan. National BioResource Project for the Rat in Japan mutant Live Animals Neurobiology RRID:RGD_1302676 1302677 NIG-III/Tj Strain is from the University of Tokushima, Japan. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo RRID:RGD_1302677 1302678 NAR/Slc non albumin rat Strain originated from Japan SLC, Inc, Shizuoka, Japan. National BioResource Project for the Rat in Japan mutant Live Animals Hematology RRID:RGD_1302678 1302679 TRMR/Kyo tremor resistant Tremor Rat which was found in a colony of outbred Wistar/Kyo in 1980 was separated to Tanabe Seiyaku Co., Ltd. in 1982. This strain is a substrain of TRM/Kyo and does not show tremor behavior. This strain carrying wild type Hcn1, is considered as segregating inbred strain of TRM. National BioResource Project for the Rat in Japan segregating_inbred Unknown Aspa 621693 RRID:RGD_1302679 1302680 SHR/Ta Strain orginated at Takeda Chemical Industries, Ltd., Osaka, Japan. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension RRID:RGD_1302680 1302681 WKY.SHRSP-(D1Smu11-D1Rat112)/Izm The desired fragment is transferred from SHRSP to WKY. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302681 1302682 FXLE18/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302682 1302683 FXLE22/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Live Animals Diabetes Obesity; Cancer RRID:RGD_1302683 1302684 F344/NHok Dwango-Heston-N(Jay) 1950-Hokkaido University, Faculty of Science(Mk) 1956-National Institute of Genetics(Ms) 1958-Hokkaido University, Laboratory of Experimental Animal Science(Hok) 1959, F68-Hokkaido University, Center for Experimental Plants & Animals National BioResource Project for the Rat in Japan inbred Unknown RRID:RGD_1302684 1302685 F344.OLETF-(D14Rat8-D14Rat26)/Tj Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating. Comprises of a 18.5 cM transferred segment. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 32584630 70077314 1 - by flanking markers 14 32389647 69559504 1 - by flanking markers 14 32593926 69517234 1 - by flanking markers 14 30320092 65026991 1 - by flanking markers RRID:RGD_1302685 1302686 F344/Stm Derived from F344/DuCrlj rats that were purchased from Charles River Kanagawa, Japan. These are maintained by brother and sister mating. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cancer RRID:RGD_1302686 1302687 WKAH/HkmSlc Wistar King A, Hokkaido Strain originated from Japan SLC, Inc., Shizuoka, Japan. National BioResource Project for the Rat in Japan inbred Live Animals RRID:RGD_1302687 1302688 ACI/NMna This strain is derived from the ACI/NMs strain bred at the Fujita Health University School of Medicine, Aichi, Japan. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1302688 1302689 WKY.SHRSP-(Ntrk3-D1Smu13)/Izm The desired fragment is transferred from SHRSP to WKY. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302689 1302690 FXLE19/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302690 1302691 ALB/Hok Albany Albany, N.Y.(Wolf)?N(Jay)to Hokkaido University, Faculty of Science(Mk)to National Institute of Genetics(Ms) 1958?Hokkaido University, Laboratory of Experimental Animal Science(Hok) 1975, F48 to Hokkaido University, Center for Experimental Plants & Animals(Hok) National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo Dentistry RRID:RGD_1302691 1302692 WKY.SHRSP-(D1Wox18-D1Rat44)/Izm The desired fragment is transferred from SHRSP to WKY. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302692 1302693 KZ-LeprfaTky A inbred strain from Zucker-fatty rats which were introduced to Takeda Chemical Industries in 1980. National BioResource Project for the Rat in Japan segregating_inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Metabolism Lepr 3001 RRID:RGD_1302693 1302694 WKA/Seac Wistar King > Aptekman > Hokkaido University 1953 > Kyushu University 1955 > Seac Yoshitomi, LTD. 1979 National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Immunology RRID:RGD_1302694 1302695 SER/Kyo spontaneously epileptic rat Spontaneously Epileptic Rat was developed as a double mutant by Serikawa by crossing zi rats (derived from SD), carrying an autosomal recessive attractin mutation with trm rats (derived from Kyo:Wistar), carrying a genomic deletion comprising Aspartate Ac National BioResource Project for the Rat in Japan segregating_inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Neurobiology Atrn|Aspa 69063|621693 RRID:RGD_1302695 1302696 FH/HamSlc fawn hooded rat Strain originated at Japan SLC, Inc., Shizuoka , Japan. National BioResource Project for the Rat in Japan mutant Live Animals Cardio Hypertension RRID:RGD_1302696 1302697 KND/Tky komeda non-diabetic rat Komeda diabetes-prone rat developed by Komeda from Long-Evans Tokushima Lean (LETL) rat at Tokyo Medical College in 1996. Komeda non Diabetic Rats were established simultaneusely as controls. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo Diabetes Obesity RRID:RGD_1302697 1302698 SDR/Slc Spontaneous dwarf rat The G to A substitution at the end of the 3rd intron of the rat Growth hormone gene was identified as the cause of the dwarf phenotype. This spontaneous mutation affected the 3' splice/acceptor site. Strain is from Japan SLC, Inc., Shizuoka, Japan. National BioResource Project for the Rat in Japan, Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-05-04) Metabolism Gh1sdr 12880380 10 95692240 95694117 1 - by flanking markers 10 94237414 94239391 1 - by flanking markers 10 94486204 94488181 1 - by flanking markers 10 91228102 91230079 1 - by flanking markers RRID:RRRC_00066 1302699 LEXF8D/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302699 1302700 HOB/Snk hobble rat HOB rat was identified in the F344 congenic rats (N12F13) to which the coat color locus (C) of fatty rat has been transferred in Sankyo Co., Ltd. Introduced to Kyoto University in 1999 at F13. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Neurobiology Unc5c|Unc5chob 735109|12802353 2 239365109 239721231 1 - by flanking markers 2 265573406 265926229 1 - by flanking markers 2 247045813 247397483 1 - by flanking markers 2 230180353 230535219 1 - by flanking markers RRID:RGD_1302700 1302701 LEW/SsNSlc Inbreeding of the Lewis rat is begun by Dr. Margaret Lewis from a Wistar stock. In 1924, at F20 to Aptekmanm and Bogdon. In 1958, at F31 to Silvers, who distributed this strain. subsequently. LEW/SsNSlc rats were descended from a colony obtained from the National Institutes of Health, Bethesda, Maryland USA in 1994 to Japan SLC, Inc.,Shizuoka, Japan. National BioResource Project for the Rat in Japan inbred Live Animals (as of 2020-08-26) Immunology RRID:RGD_1302701 1302702 TRM/Kyo tremor rat In 1980, a spontaneous tremor mutant rat was found in the colony of Kyo:Wistar (Yamada, 1985). This disorder was found to be caused by an autosomal recessive gene and was designated tremor (tm). Deletion of Aspa gene was identified in the animal with no aspartoacylase activity in the brain and measurable level of activity in the kidney. TRM was established as a segregating inbred strain. In F18 progeny, a rat which did not have tm mutation was separated and established as a control strain of WTC (NBRP No.0020). (Dec 8, 2010) National BioResource Project for the Rat in Japan segregating_inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-01-03) Neurobiology Aspa|Hcn1A354V 621693|13464319 RRID:RGD_1302702 1302703 WKY.SHRSP-(D1Wox29-D1Rat112)/Izm The desired fragment is transferred from SHRSP to WKY. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302703 1302704 WKY.SHRSP-(D1Wox29-D1Rat199)/Izm The desired fragment is transferred from SHRSP to WKY. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302704 1302705 WKY.SHRSP-(D1Wox29-D1Smu13)/Izm The desired fragment is transferred from SHRSP to WKY. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302705 1302706 F344.OLETF-(D5Rat32-D5Rat26)/Tj Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.37.4 cM segment of the OLETF genome was transferred. National BioResource Project for the Rat in Japan congenic Unknown 5 119332868 139659574 1 - by flanking markers 5 121495621 141933383 1 - by flanking markers 5 117554114 138123957 1 - by flanking markers 5 113558156 132686472 1 - by flanking markers RRID:RGD_1302706 1302707 LEXF3/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302707 1302708 FXLE17/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Diabetes Obesity; Cancer RRID:RGD_1302708 1302709 WKY/Hcm Strain is from the Hyogo College of Medicine, Japan. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension RRID:RGD_1302709 1302710 LEXF2B/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cancer RRID:RGD_1302710 1302711 ExHC/Seac Isolated from Sprague-Dawley (SD/Jcl) rats by Imai and Matsumura by selection for high serum cholesterol under high cholesterol diet for 7 days (app. 250 mg/dl, normal 100 mg/dl) in 1973. Kyushu University > Seac Yoshitomi, LTD. 1993 National BioResource Project for the Rat in Japan inbred Unknown RRID:RGD_1302711 1302712 ZIMY/Kyo Zitter Masao Yamada ZIMY was produced by crossing tremor (TRM) rat and zitter (ZI) rat at Kyoto University. zi/zi, tm<+/+>. ZIMY (Zitter Masao Yamada). This strain is homozygous for zi and wild-type for tm. ZIMY (Zitter Masao Yamada) National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2020-12-17) Neurobiology Atrn 69063 3 118539268 118701177 1 - by flanking markers 3 129934303 130067267 1 - by flanking markers 3 123434409 123567922 1 - by flanking markers 3 118110320 118244326 1 - by flanking markers RRID:RGD_1302712 1302713 F344.OLETF-(D8Rat58-D8Mgh17)/Tj Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.37.4 cM segment of the OLETF genome was transferred. National BioResource Project for the Rat in Japan congenic Unknown 8 19796514 48675424 1 - by flanking markers 8 21850030 48631820 1 - by flanking markers 8 50007641 50007776 1 - by flanking markers 8 46008836 46008974 1 - by flanking markers RRID:RGD_1302713 1302714 KZC/Tky Komeda Zucker Creeping rat Komeda Zucker Creeping rat derived from a closed colony of the Zucker fatty rat by spontaniously mutation at Tokyo Medical College in 1983. National BioResource Project for the Rat in Japan segregating_inbred Cryopreserved Embryo; Cryopreserved Sperm Neurobiology Reln 3553 RRID:RGD_1302714 1302715 WKY.SHRSP-(D1Wox18-D1Wox29)/Izm The desired fragment is transferred from SHRSP to WKY. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302715 1302716 OM/NSlc Osborne-Mendel rat The Instutite of Medical Science, The University of Tokyo to Slc (1985) National BioResource Project for the Rat in Japan inbred Live Animals RRID:RGD_1302716 1302717 ACI/NHok NIH to Tokyo Biochemical Research Institute(Tbi) to Hokkaido University, Laboratory of Experimental Animal Science(Hok) 1967, F87 to Hokkaido University, Center for Experimental Plants & Animals(Hok) 1982, F135 National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302717 1302718 HWY/Slc hairless wistar yagi Strain is from Japan SLC, Inc., Shizuoka, Japan. National BioResource Project for the Rat in Japan mutant Live Animals Dermatology RRID:RGD_1302718 1302719 DON/Kyo Donryu rat Japanese albino rats > R.Sato, Nippon Rat(1950) > Kyo (1978, F64), formaly DONRYU/2 National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1302719 1302720 CXH10/Tj Strain is from the University of Tokushima, Japan. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo Metabolism; Immunology RRID:RGD_1302720 1302721 LEC/Tj Found in Long Evans strain at Kobe University > Inbreeding at Hokkaido University > Otsuka Pharmaceutical Co. > The University of Tokushima 1989 National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo Cancer Atp7bhts 11532742 16 74607988 74680080 1 - by flanking markers 16 74495179 74575822 1 - by flanking markers 16 74865516 74944935 1 - by flanking markers 16 69952286 70024404 1 - by flanking markers RRID:RGD_1302721 1302722 PVG/Seac Piebald Virol Glaxo Strain is from Seac Yoshitomi, LTD., Fukuoka, Japan. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Immunology RRID:RGD_1302722 1302723 LEXF5/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cancer RRID:RGD_1302723 1302724 SHR/Hcm Strain is from the Hyogo College of Medicine, Japan. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo Cardio Hypertension RRID:RGD_1302724 1302726 ZI/Kyo Zitter rat was detected in a Sprague Dawley colony (SD) in Hannover in 1978 by Rehm. 1983 introduced to Kyoto University and established ZI/Kyo. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Neurobiology Atrnzi 40902832 3 118539268 118701177 1 - by flanking markers 3 129934303 130067267 1 - by flanking markers 3 123434409 123567922 1 - by flanking markers 3 118110320 118244326 1 - by flanking markers RRID:RGD_1302726 1302727 SHRSR/Ta Strain is from Takeda Chemical Industries, Ltd., Osaka, Japan. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension RRID:RGD_1302727 1302728 MES/Slc Matsumoto Eosinophilia Shinshu Derived frm one pregnant SPF SD rat from a closed colony of SD rats at Japan SLC. 3 males and 5 females offspring had high eosinophil count at 10 weeks of age, these were bred brother x sister mating to generate these rats. Institute of Experimental Animals, Shinshu University School of Medicine to Slc (1999) National BioResource Project for the Rat in Japan mutant Live Animals Hematology Cybam1Sdi 13209000 19 52713150 52721609 1 - by flanking markers 19 65959818 65967224 1 - by flanking markers 19 55249634 55257824 1 - by flanking markers 19 50487598 50495669 1 - by flanking markers RRID:RGD_1302728 1302729 LEA/Tj Found in Long Evans strain at Kobe University; Inbreeding at Hokkaido University; Otsuka Pharmaceutical Co.; The University of Tokushima 1989 National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo Cancer RRID:RGD_1302729 1302795 HTG Prague hypertriglyceridemic These were originally derived from a colony of Wistar rats. Animals with high plasma triglyceride levels were selected as breeding pair and their offsprings used for further breeding. Institute of Physiology, Academy of Sciences Prague, Czech Republic inbred Unknown RRID:RGD_1302795 1302921 F344-Tg(NPHS2-HBEGF)Wig hDTR (HBEGF) cDNA was inserted at the 3' of the 2.5 kb human podocin (NPHS2) promoter. This transgenic construct was released by XbaI/HindIII digestion and injected into the pronuclei of fertilized eggs. Division of Nephrology, Department of Internal Medicine, University of MIchigan, Ann Habor, Michigan transgenic Unknown RRID:RGD_1302921 1303393 LEC/Ncu These rats were established from a closed colony of Long-Evans. Nagoya City University Medical School, Nagoya, Aichi, Japan inbred Unknown RRID:RGD_1303393 1304487 BBDR/Wor Diabetic resistant BB rats. These are derived from a viral antibody free (VAF)colony which was maintained at University of Massachusetts and is now at BRM. In 1977, Butler et al. began inbreeding BB rats at the University of Massachusetts Medical Center (laboratory code Wor) with 300 breeders purchased from the Bio-Breeding Laboratories. In 1978, during inbreding, pathogen-free rodent barrier system was introduced and a strain disease resistant (DR) by was established by selective breeding of diabtes free progenies. inbred Unknown RRID:RGD_1304487 1331811 LEW.BN-(D10Rat32-D10Rat133)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with LEW females to transfer the desired locus to LEW background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 53786347 65668639 1 - by flanking markers 10 53381898 64823355 1 - by flanking markers 10 53630865 53631032 1 - by flanking markers 10 51779662 51779830 1 - by flanking markers RRID:RGD_1331811 1331812 LEW.BN-(D10Rat83-D10Rat133)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with LEW females to transfer the desired locus to LEW background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 46860047 65668639 1 - by flanking markers 10 46728252 64823355 1 - by flanking markers 10 46955258 46955430 1 - by flanking markers 10 45393829 45394002 1 - by flanking markers RRID:RGD_1331812 1331813 BN.GK-(D8Rat29-D8Got130)/Ox This congenic strain contains the Nidd/gk5 locus transferred onto the BN background. GK rats are from a colony in Paris (CNRS) obtained in 1995. BN rats were initially obtained from Charles River Laboratories, Margate, UK. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK congenic Unknown 8 74769551 87069779 1 - by flanking markers 8 76345502 89012772 1 - by flanking markers 8 89482236 89482480 1 - by flanking markers 8 82872062 82872307 1 - by flanking markers RRID:RGD_1331813 1331814 BN.GK-(D8Got302-D8Got130)/Ox This congenic strain contains the Nidd/gk5 locus transferred onto the BN background. GK rats are from a colony in Paris (CNRS) obtained in 1995. BN rats were initially obtained from Charles River Laboratories, Margate, UK. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK congenic Unknown 8 48185711 87069779 1 - by flanking markers 8 48160321 89012772 1 - by flanking markers 8 49533872 89482480 1 - by flanking markers 8 45539309 82872307 1 - by flanking markers RRID:RGD_1331814 1331815 LEW/Mol LEW/Mol This substrain can be traced originally to Scripps Clinic, La Jolla, to University of Pennsylvania to Simonsen Laboratories in 1966, to Institute of Pathological Anatomy, University of Copenhagen, Denmark 1973. From University of Copenhagen to M&B A/S (Mollegaard Breeding Center Ltd., Denmark ) from 1977 to 2002. (now Taconic Europe) Mollegaard Breeding Center Ltd., Denmark inbred Unknown Ncf1 61307 RRID:RGD_1331815 1331816 DA.ACI-(D10Rat2-D10Rat29)/Kini (DA x ACI) x DA backcross in the second generation transfered 40 cM of DNA from ACI to DA. Neuroimmunology Unit, Center for Molecular Medicine, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology; Immunology 10 68842878 68843272 1 - by flanking markers 10 67642121 110568670 1 - by flanking markers 10 67988035 110992275 1 - by flanking markers 10 107057622 107057807 1 - by flanking markers RRID:RGD_1331816 1331817 BN.LEW-(D10Rat32-D10Mgh4)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with BN males to transfer the desired locus to BN background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 53786347 96799937 1 - by flanking markers 10 53381898 95372987 1 - by flanking markers 10 53630865 95638337 1 - by flanking markers 10 51779662 92369470 1 - by flanking markers RRID:RGD_1331817 1331818 LEW.BN-(D10Rat43-D10Mco4)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with LEW females to transfer the desired locus to LEW background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 23428127 42042465 1 - by flanking markers 10 22266756 41793199 1 - by flanking markers 10 22402817 41976505 1 - by flanking markers 10 22918268 40741723 1 - by flanking markers RRID:RGD_1331818 1331819 F344/Eer F344/Eer Inbred strain originated from animals purchased from Harlan Industries, Indianapolis, Indiana Dept. of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois inbred Unknown RRID:RGD_1331819 1331820 LEW.BN-(D10Got9-D10Rat2)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with LEW females to transfer the desired locus to LEW background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 5641331 5641541 1 - by flanking markers 10 4578252 110568670 1 - by flanking markers 10 5760565 110992275 1 - by flanking markers 10 5684047 107057807 1 - by flanking markers RRID:RGD_1331820 1331821 LEW.BN-(D10Wox26-D10Arb4)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with LEW females to transfer the desired locus to LEW background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 30343658 46737218 1 - by flanking markers 10 30131785 46592053 1 - by flanking markers 10 30303447 46835685 1 - by flanking markers 10 29659462 45274336 1 - by flanking markers RRID:RGD_1331821 1331822 DA.ACI-(D10Rat2-D10Rat6) DA.ACI-(D10Rat2-D10Rat29) congenic rats were backcrossed to parental DA rats and progeny were intercrossed to obtain homozygous recombinations within the desired region. Neuroimmunology Unit, Center for Molecular Medicine, Stockholm, Sweden congenic Unknown 10 106310811 106310957 1 - by flanking markers 10 104746165 110568670 1 - by flanking markers 10 105077900 110992275 1 - by flanking markers 10 101435864 107057807 1 - by flanking markers RRID:RGD_1331822 1331823 LEW.BN-(D10Rat43-D10Rat27)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with LEW females to transfer the desired locus to LEW background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 23428127 77092169 1 - by flanking markers 10 22266756 74127968 1 - by flanking markers 10 22402817 75983805 1 - by flanking markers 10 22918268 73453136 1 - by flanking markers RRID:RGD_1331823 1331824 DA.ACI-(D10Rat219-D10Rat29) DA.ACI-(D10Rat2-D10Rat29) congenic rats were backcrossed to parental DA rats and progeny were intercrossed to obtain homozygous recombinations within the desired region. Neuroimmunology Unit, Center for Molecular Medicine, Stockholm, Sweden congenic Unknown 10 68842878 81986757 1 - by flanking markers 10 67642121 80884595 1 - by flanking markers 10 67988035 81042642 1 - by flanking markers 10 78306880 78307017 1 - by flanking markers RRID:RGD_1331824 1331826 LEW.BN-(D10Mgh7-D10Rat27)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with LEW females to transfer the desired locus to LEW background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 56170962 77092169 1 - by flanking markers 10 55720558 74127968 1 - by flanking markers 10 55978483 75983805 1 - by flanking markers 10 54098674 73453136 1 - by flanking markers RRID:RGD_1331826 1331827 DA.ACI-(D10Rat10-D10Rat142) DA.ACI-(D10Rat2-D10Rat29) congenic rats were backcrossed to parental DA rats and progeny were intercrossed to obtain homozygous recombinations within the desired region. Neuroimmunology Unit, Center for Molecular Medicine, Stockholm, Sweden congenic Unknown 10 92448353 100301488 1 - by flanking markers 10 91113514 98868127 1 - by flanking markers 10 91345679 99171690 1 - by flanking markers 10 88207600 95803900 1 - by flanking markers RRID:RGD_1331827 1331828 DA.ACI-(D10Rat12-D10Rat144) DA.ACI-(D10Rat2-D10Rat29) congenic rats were backcrossed to parental DA rats and progeny were intercrossed to obtain homozygous recombinations within the desired region. Neuroimmunology Unit, Center for Molecular Medicine, L8:04, Stockholm, Sweden congenic Unknown 10 86290650 99198997 1 - by flanking markers 10 85276455 97759008 1 - by flanking markers 10 85487741 98044833 1 - by flanking markers 10 82538790 94725019 1 - by flanking markers RRID:RGD_1331828 1331829 BN.LEW-(D9Got8-D9Got200)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with BN males to transfer the desired locus to BN background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 9 3811425 3811711 1 - by flanking markers 9 2597055 9698468 1 - by flanking markers 9 2657610 10706733 1 - by flanking markers 9 1185844 4302019 1 - by flanking markers RRID:RGD_1331829 1331830 F344.BN-(D5Rat1-D5Mit5)/Dlw This congenic strain carries the BN Edpm5 QTL on an F344 background. This strain is maintained at Oakland University, Rochester, MI, USA Department of Biological Sciences, Oakland University, Rochester, MI congenic Unknown 5 35911094 109163425 1 - by flanking markers 5 39876314 112058005 1 - by flanking markers 5 35225432 108092802 1 - by flanking markers 5 34730116 104251008 1 - by flanking markers RRID:RGD_1331830 1331831 LEW.BN-(D10Rat173-D10Rat133)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with LEW females to transfer the desired locus to LEW background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 37505289 65668639 1 - by flanking markers 10 37209026 64823355 1 - by flanking markers 10 37435916 37436126 1 - by flanking markers 10 36244402 36244613 1 - by flanking markers RRID:RGD_1331831 1331832 BN.LEW-(D10Rat72-D10Arb4)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with BN males to transfer the desired locus to BN background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 46737116 46737218 1 - by flanking markers 10 46591952 46592053 1 - by flanking markers 10 46835584 46835685 1 - by flanking markers 10 45274234 45274336 1 - by flanking markers RRID:RGD_1331832 1331833 DA.ACI-(D10Rat15-D10Rat29) DA.ACI-(D10Rat2-D10Rat29) congenic rats were backcrossed to parental DA rats and progeny were intercrossed to obtain homozygous recombinations within the desired region. Neuroimmunology Unit, Center for Molecular Medicine, L8:04, Stockholm, Sweden congenic Unknown 10 68842878 96667338 1 - by flanking markers 10 67642121 95243104 1 - by flanking markers 10 67988035 95508221 1 - by flanking markers 10 92238327 92238497 1 - by flanking markers RRID:RGD_1331833 1331834 BN.LEW-(D10Rat100-D10Rat126)/Rj This congenic strain was derived from female LEW rats and male BN rats obtained from the Janvier breeding center, Le Genest-Saint-Isle, France. F1 offsprings were crossed with BN males to transfer the desired locus to BN background. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 26434477 26434620 1 - by flanking markers 10 26363403 42526523 1 - by flanking markers 10 26517020 42716241 1 - by flanking markers 10 25790546 41482228 1 - by flanking markers RRID:RGD_1331834 1331836 WKY/Eer WKY/Eer Inbred strain originated from animals purchased from Harlan Industries, Indianapolis, Indiana Dept. of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois inbred Unknown RRID:RGD_1331836 1354669 BN/OrlIcoCrlf Strain selected by Silvers and Billingham in 1958 after cross-breeding of histocompatible animals from a colony of mutants. These animals were then maintained in closed colony by H.D. King and P. Aptekman at the National Institutes of Health (NIH) (Bethesda, MD, USA). The strain was obtained by Microbiological Associates, Inc., Department of Laboratory Animals, Walkersville, Maryland, USA in 1969 and introduced into CNRS/CSEAL in Orleans, France in 1988. It was then transferred to Charles River Laboratories France in 1991. Charles River France inbred Unknown RRID:RGD_1354669 1354670 F344/IcoCrlf These are inbred rats that were bought from Charles River, Les Oncins near Lyon, France. Charles River France inbred Unknown RRID:RGD_1354670 1357172 WF.BBDR-(D4Arb29-D4Rat44)/Wor This congenic was generated by the marker-assisted protocol where a segment of BBDR/Wor is transferred to WF background and the animals were screened using microsatellite markers. University of Massachusetts Medical School, Worcerster, MA congenic Unknown 4 63276741 121645621 1 - by flanking markers 4 63250011 183837621 1 - by flanking markers 4 63537179 63537431 1 - by flanking markers 4 64528739 64528994 1 - by flanking markers RRID:RGD_1357172 1357173 SS.MNS-(Vamp2-D10M11Mit84)/Mco This congenic strain is derived by introgressing a desired region of chr 10 from MNS to the SS/Jr recipient. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown Vamp2 3949 10 55848264 55852132 1 - by flanking markers 10 55418231 55422465 1 - by flanking markers 10 55675171 55679405 1 - by flanking markers 10 53793581 53797815 1 - by flanking markers RRID:RGD_1357173 1357174 BBDR.BBDP-(D4Mit6-D4Mit24)/Rhw S. Bieg and coworkers (1998) generated this congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 ñ 53 days of age after the first and 67 ± 10 days of age after the 9th cycle. Lacks one C nucleotide at 478 position which causes a frameshift mutation in the ORF of exon 3 forming a significantly truncated protein. Department of Medicine University of Washington, Seattle, Washington congenic Unknown 4 75732943 78039637 1 - by flanking markers 4 141978848 144249450 1 - by flanking markers 4 77307388 79575658 1 - by flanking markers 4 76647384 78882945 1 - by flanking markers RRID:RGD_1357174 1357175 F344.DR-(D4Mit6-D4Mit24)-Tg(Gimap5)Mcwi Wild type allele of Gimap5 from BN was microinjected into the pronuclei of fertilized eggs from a T cell lymphopenic congenic strain F344.DR-(D4Mit6-D4Mit24) Department of Physiology, Medical College of Wisconsin, Milwaukee Wisconsin transgenic Unknown RRID:RGD_1357175 1357176 WF.BBDR-(D4Arb29-D4Rat96)/Wor This congenic was generated by the marker-assisted protocol where a segment of BBDR/Wor is transferred to WF background and the animals were screened using microsatellite markers. University of Massachusetts Medical School, Worcerster, MA congenic Unknown 4 63276741 65434807 1 - by flanking markers 4 63250011 65397196 1 - by flanking markers 4 63537179 65577249 1 - by flanking markers 4 64528739 66609456 1 - by flanking markers RRID:RGD_1357176 1357177 F344.DR(DP)-(D4Mit6-D4Mit24)/Rhw The lymphopenia locus from BBDR.BBDP-(D4Mit6-D4Mit24) was transferred onto F344 by marker assisted selection in five cycles of cross-intercross breeding. Department of Medicine University of Washington, Seattle, Washington, Rat Resource & Research Center congenic Cryopreserved Embryo 4 75732943 78039637 1 - by flanking markers 4 141978848 144249450 1 - by flanking markers 4 77307388 79575658 1 - by flanking markers 4 76647384 78882945 1 - by flanking markers RRID:RRRC_00082 1357178 CD Cohen diabetic rat Originally developed by late professor A.M. Cohen in Israel nearly 40 years ago. These were genetically selected from the Hebrew University albino rats. When fed a copper-poor high-sucrose diet these develop impaired carbohydrate metabolism. Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel inbred Unknown RRID:RGD_1357178 1357179 SS.WKY-(D2N35-Mme),MNS-(D10Mit11-D10M11Mit119)/Mco SS.WKY-(D2N35-Mme)/Mco and SS.MNS-(D10Mit11-D10M11Mit119)/Mco were crossed and the F1 were backcrossed to SS.WKY-(D2N35-Mme)/Mco. Rats that were homozygous on the chr 2 loci were selected and crossed with the ones that were homozygous on the chr 10 loci. This produced the double congenic strain which was maintained by brother-sister mating Medical College of Ohio, Toledo, Ohio, USA congenic Unknown RRID:RGD_1357179 1357180 SS.LEW-(D8Chm14-D8Rat16)/Ayd Congenic strain produced from a SS/Jr strain and a LEW/CrlBR strain purchased from Charles Rivers, Quebec, Canada Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown Grik4 2734 8 45510258 98878889 1 - by flanking markers 8 45279673 100781055 1 - by flanking markers 8 46804134 101305168 1 - by flanking markers 8 42903043 94388843 1 - by flanking markers RRID:RGD_1357180 1357181 CDR/Ygl Cohen rats that had an oral tolerance test with blood glucose levels <180mg/dl were selected. More stringent criteria was set during the secondary inbreeding: rats with blood glucose levels <140mg/dl were selected. Brother and sister mating was carried on for 10 additional generations. Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel; Israeli Rat Genome Center, Ashkelon, Israel inbred Unknown RRID:RGD_1357181 1357182 Eker-Tg(Tsc2)28Hin Wild type Tsc2 transgene was constructed from the Tsc2 cDNA from BN rat and was microinjected into single male pronuclei. Eggs were cultured and tranferred into female wistar which were mated with Eker rats. Department of Experimental Pathology, Cancer Institute, Toshima-ku, Tokyo, Japan transgenic Unknown Tsc2 3908 RRID:RGD_1357182 1357183 SS.MNS-(D10Mco10-Aldoc)/Jr This congenic strain is derived by introgressing a desired region of chr 10 from MNS to the SS/Jr recipient. Medical College of Ohio, Toledo congenic Unknown Nos2 3185 10 6849272 65072453 1 - by flanking markers 10 5706467 65456957 1 - by flanking markers 10 6908932 66221621 1 - by flanking markers 10 6813971 63851208 1 - by flanking markers RRID:RGD_1357183 1357184 Crl:ZUC-Leprfa Zucker rats The obese and fatty condition appeared spontaneously in the 13M stock and was reported by Lois Zucker and Theodore Zucker in 1960 at the Laboratory of Comparative Pathology in Stow, Massachusetts. These came to Charles River in 1985 from a research colony maintained at a pharmaceutical company. Charles River Laboratories outbred Unknown Leprfa 13432153 RRID:RGD_1357184 1357185 RHA.Gunn-Ugt1a1j/N RHA/N rats were crossed with Gunn rats. F1 hybrids were intercrossed for 12 cycles while selecting for jaundice loci. Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD, USA congenic Unknown RRID:RGD_1357185 1357186 Gunn-Ugt1a1j/BluHsd Gunn rat This mutation was first observed in normal Wistar albino rats in a breeding colony at Cannaught Laboratories in 1934. Jaundice was evident at birth or shortly after and was persistant throughout life. Harlan mutant Unknown Ugt1a1j 13432064 9 87091241 87098362 1 - by flanking markers 9 94982916 94990037 1 - by flanking markers 9 95295701 95302822 1 - by flanking markers 9 88801344 88808465 1 - by flanking markers RRID:RGD_1357186 1357187 WF.BBDR-(D4Rat16-D4Got39)/Wor This congenic was generated by the marker-assisted protocol where a segment of BBDR/Wor is transferred to WF background and the animals were screened using microsatellite markers. University of Massachusetts Medical School, Worcerster, MA congenic Unknown 4 56704868 56704967 1 - by flanking markers 4 56868238 56868336 1 - by flanking markers 4 57101077 57101175 1 - by flanking markers 4 58432133 58432232 1 - by flanking markers RRID:RGD_1357187 1357189 SS.LEW-(D8Rat56-D8Rat51)/Ayd Congenic strain produced from a SS/Jr strain and a LEW/CrlBR strain purchased from Charles Rivers, Quebec, Canada Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 8 8294860 29559867 1 - by flanking markers 8 9505886 30947391 1 - by flanking markers 8 9531047 30918267 1 - by flanking markers 8 8462195 28243068 1 - by flanking markers RRID:RGD_1357189 1357190 SS.MNS-(Adh1-D2Mit5)/Mco This congenic strain contains an MNS chromosome 2 segment transferred to an SS/Jr background Medical College of Ohio, Toledo, Ohio, USA congenic Unknown Adh1 2044 2 235799396 235811584 1 - by flanking markers 2 262090818 262102977 1 - by flanking markers 2 243550655 243562243 1 - by flanking markers 2 226797303 226808892 1 - by flanking markers RRID:RGD_1357190 1357191 CDS/Ygl Cohen diabetic-sensitive rat Cohen rats that had an oral tolerance test with blood glucose levels >180mg/dl were selected. More stringent criteria was set during the secondary inbreeding: rats with blood glucose levels >230mg/dl were selected. Brother and sister mating was carried on for 10 additional generations. Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel inbred Unknown RRID:RGD_1357191 1357192 WF.BBDR-(D4Got39-D4Rat44)/Wor This congenic was generated by the marker-assisted protocol where a segment of BBDR/Wor is transferred to WF background and the animals were screened using microsatellite markers. University of Massachusetts Medical School, Worcerster, MA congenic Unknown 4 56704868 121645621 1 - by flanking markers 4 56868238 183837621 1 - by flanking markers 4 57101077 57101175 1 - by flanking markers 4 58432133 58432232 1 - by flanking markers RRID:RGD_1357192 1357193 WF.BBDR-(D4Got51-D4Rat44)/Wor This congenic was generated by the marker-assisted protocol where a segment of BBDR/Wor is transferred to WF background and the animals were screened using microsatellite markers. University of Massachusetts Medical School, Worcerster, MA congenic Unknown 4 70123187 121645621 1 - by flanking markers 4 136548956 183837621 1 - by flanking markers 4 71744558 71744763 1 - by flanking markers 4 71241724 71241930 1 - by flanking markers RRID:RGD_1357193 1357194 WF.BBDR-(D4Rat96-D4Rat44)/Wor This congenic was generated by the marker-assisted protocol where a segment of BBDR/Wor is transferred to WF background and the animals were screened using microsatellite markers. University of Massachusetts Medical School, Worcerster, MA congenic Unknown 4 65434709 121645621 1 - by flanking markers 4 65397099 183837621 1 - by flanking markers 4 65577152 65577249 1 - by flanking markers 4 66609358 66609456 1 - by flanking markers RRID:RGD_1357194 1357195 SS.MNS-(Aldoc-D10Mco1)/Jr This congenic strain is derived by introgressing a desired region of chr 10 from MNS to the SS/Jr recipient. Medical College of Ohio, Toledo, Ohio, USA congenic Unknown Nos2 3185 10 67677924 67678060 1 - by flanking markers 10 63366082 63366218 1 - by flanking markers 10 64648175 64648311 1 - by flanking markers 10 61345276 61345413 1 - by flanking markers RRID:RGD_1357195 1357196 WF.BBDR-(D4Arb29-D4Rat265)/Wor This congenic was generated by the marker-assisted protocol where a segment of BBDR/Wor is transferred to WF background and the animals were screened using microsatellite markers. University of Massachusetts Medical School, Worcerster, MA congenic Unknown 4 63276741 82266081 1 - by flanking markers 4 63250011 148715224 1 - by flanking markers 4 63537179 84053053 1 - by flanking markers 4 64528739 83007655 1 - by flanking markers RRID:RGD_1357196 1357345 DA/K Dark Agouti/Karlsburg Dark agouti rats which were bred and housed in Dept. of Laboratory Animal Science, Karlsburg, Germany Dept. of Laboratory Animal Science, Inst. of Pathology, University of Greifswald,D-17495, Karlsburg, Germany inbred Unknown RRID:RGD_1357345 1357346 BB.SHR-(D4Mit6-Spr)/K BB/OK lymphopenic rats were crossed with non-lymphopenic, spontaneously hypertensive SHR/Mol rats. Rats heterzygous for D4Mit6, Npy, and Spr and homozygous for BB alleles were selected. After 5 backcross generations, rats were intercrossed. Rats homozygous at SHR loci of interest were selected. Department of Laboratory Animal Science, Inst of Pathophysiology, University of Greifswald, Karlsburg, Germany congenic Unknown Npy|Spr 3197|3753 4 75732943 119369308 1 - by flanking markers 4 141978848 181496612 1 - by flanking markers 4 77307388 116916073 1 - by flanking markers 4 76647384 117676292 1 - by flanking markers RRID:RGD_1357346 1357417 SD-Tg(Npy)400Mcwi 14.5 kb lambda clone of the rat Npy gene was subcloned with a polylinker that had NotI and EcoRI restriction sites. This transgene that was released by NotI digestion contained ~5kb 5'and ~1kb 3' and was injected into the pronuclei of fertilized SD rats. Founders were mated with SD females. F1 animals were mated with SD females till line 400 hemizygous animals were developed that had 5 copies of the Npy gene. Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_1357417 1357953 WAG/RijHfr Substrain of WAG, from AL Bacharach, Glaxo Ltd from Wistar stock in 1924, from Rij to Envigo (Harlan France) Envigo (Harlan France) inbred Unknown RRID:RGD_1357953 1357954 F344/NHfr Strain originated from Curtiss and Dunning 1920 at Columbia University Institute for Cancer Research, To Heston 1949 (Billingham and Silvers 1959). To National Institutes of Health in 1951 (Hansen et al 1982), Supplied by Harlan, France. Harlan France inbred Unknown RRID:RGD_1357954 1357955 WF/NHfr Wistar-Furth Substrain of Wistar Furth stock, inbred by National Institute of Health, Bethesda, MD and now available at Harlan, France. Harlan France inbred Unknown RRID:RGD_1357955 1357957 LEW/HanHfr Inbreeding of the Lewis rat is begun by Dr. Margaret Lewis from a Wistar stock. In 1924, at F20 to Aptekmanm and Bogdon. In 1958, at F31 to Silvers, who distributed this strain. subsequently. To Central Institute for Laboratory Animal Breeding, Hannover, in 1973 at F58. In 1994, to Harlan Netherlands through acquisition of Central Institute for Laboratory Animal Breeding. Harlan became Envigo in 2015 ENVIGO France inbred Unknown The LEW/HanHsd is very susceptible to the induction of EAE, while the LEW/SsNHsd is not susceptible to the induction of EAE RRID:RGD_1357957 1357958 BN/RijHfr Substrain of BN, from Billingham and Silvers 1958, from Harlan Rijnswijk, supplied by Harlan France. Harlan France inbred Unknown RRID:RGD_1357958 1357959 FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi The Rf-2 region of chromosome 1 is transferred from BN to the genomic background of FHH. Department of Physiology, Medical College of Wisconsin, Milwaukee Wisconsin congenic Live Animals Ctsc|Grm5|Nox4|Rab38|Tyr 2445|2746|620600|628752|1589755 1 157084760 158516775 1 - by flanking markers 1 150775310 152202960 1 - by flanking markers 1 140879679 142314355 1 - by flanking markers RRID:RGD_1357959 1357960 LE/CpbHfr Substrain of LE which was bred at Harlan CPB now at Harlan France. Envigo (Harlan France) inbred Unknown RRID:RGD_1357960 1357974 BB.SHR-(D4Got41-Gimap5)/K Originated from BB.SHR-(D4Got41-Tacr1) rats crossed with BB/OK rats to create a congenic substrain. Dept. of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany congenic Unknown Gimap5 628871 4 60262965 76843214 1 - by flanking markers 4 60179409 143073003 1 - by flanking markers 4 60439127 78386683 1 - by flanking markers 4 61697658 77701025 1 - by flanking markers RRID:RGD_1357974 1357975 SS.LEW-(D1Mco4-D1Rat18)/Mco This strain was constructed from the progenitor strain SS.LEW-(D1Uia8-D1Rat18)/Mco by crossing the progenitor strain to SS rats to get F1 followed by F1 X F1 intercross to get F2 which was screened for the desired recombinants. Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown 1 29841428 43747532 1 - by flanking markers 1 33073397 50297622 1 - by flanking markers 1 31647701 49454378 1 - by flanking markers 1 29038037 49268520 1 - by flanking markers RRID:RGD_1357975 1357976 BB.SHR-(D4Got41-D4Rat171)/K Originated from BB.SHR-(D4Got41-Tacr1) rats crossed with BB/OK rats to create a congenic substrain. Department of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany congenic Unknown 4 60262965 87996003 1 - by flanking markers 4 60179409 154162556 1 - by flanking markers 4 60439127 89342035 1 - by flanking markers 4 61697658 88217207 1 - by flanking markers RRID:RGD_1357976 1357977 SS.LEW-(D1Mco8-D1Rat213)/Mco This strain was constructed from the progenitor strain SS.LEW-(D1Uia8-D1Rat18)/Mco by crossing the progenitor strain to SS rats to get F1 followed by F1 X F1 intercross to get F2 which was screened for the desired recombinants. Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown 1 32329137 81548909 1 - by flanking markers 1;9 84537073;7947583 84537228;7947744 1 - by flanking markers;1 - by flanking markers 1 83282659 83282814 1 - by flanking markers 1 81777564 81777720 1 - by flanking markers RRID:RGD_1357977 1357978 SS.MNS-(D2Mit6-D2Rat303)/Ayd Congenic strain was created by backcrossing congenic strain SS.MNS-(D2Mit6-Adh1)/Lt strain into the parental Dahl Salt-sensitive (SS) strain Centre Hospitalier de L'Universite de Montreal (CHUM), Montreal, Quebec,Canada congenic Unknown 2 77630629 131522430 1 - by flanking markers 2 98037122 155130826 1 - by flanking markers 2 78321410 135646395 1 - by flanking markers 2 76539322 127460910 1 - by flanking markers RRID:RGD_1357978 1357979 SS.MNS-(Mme-D2Rat131)/Ayd Congenic strain was created by backcrossing congenic strain SS.MNS-(D2Mit6-Adh1)/Lt strain into the parental Dahl Salt-sensitive (SS) strain Centre Hospitalier de L'Universite de Montreal (CHUM), Montreal, Quebec,Canada congenic Unknown Mme 3098 2 153031724 179302663 1 - by flanking markers 2 173193501 206015340 1 - by flanking markers 2 153799203 186612024 1 - by flanking markers 2 147686913 172711135 1 - by flanking markers RRID:RGD_1357979 1357980 BB.SHR-(D4Got41-Tacr1)/K Congenic BB.LL rats were established as speed-congenics by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats and marker-aided selection in 1997. Dept. of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Metabolism Tacr1 3811 4 60262965 116780394 1 - by flanking markers 4 60179409 178095041 1 - by flanking markers 4 60439127 113416139 1 - by flanking markers 4 61697658 115089733 1 - by flanking markers RRID:RGD_1357980 1357981 SS.LEW-(D3Mco21-D3Rat17)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D3Rat52-D3Rat17)/Ayd Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 3 68499987 121619110 1 - by flanking markers 3 79183926 133513825 1 - by flanking markers 3 72672290 127023997 1 - by flanking markers 3 70348525 121056321 1 - by flanking markers RRID:RGD_1357981 1357982 SS.LEW-(D3Rat52-D3Chm63)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D3Rat52-D3Rat17)/Ayd Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 3 14051872 51161895 1 - by flanking markers 3 19410399 61857467 1 - by flanking markers 3 14090411 55245509 1 - by flanking markers 3 18311454 53781346 1 - by flanking markers RRID:RGD_1357982 1357983 SS.LEW-(D1Mco75-D1Rat18)/Mco This strain was constructed from the progenitor strain SS.LEW-(D1Uia8-D1Rat18)/Mco by crossing the progenitor strain to SS rats to get F1 followed by F1 X F1 intercross to get F2 which was screened for the desired recombinants. Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown 1;17 43747374;2897342 43747532;2897591 1 - by flanking markers;1 - by flanking markers 1 36805624 50297622 1 - by flanking markers 1 35406399 49454378 1 - by flanking markers 1 32765502 49268520 1 - by flanking markers RRID:RGD_1357983 1357984 SS.MNS-(D2Mit6-D2Rat166)/Ayd Congenic strain was created by backcrossing congenic strain SS.MNS-(D2Mit6-Adh1)/Lt strain into the parental Dahl Salt-sensitive (SS) strain Centre Hospitalier de L'Universite de Montreal (CHUM), Montreal, Quebec,Canada congenic Unknown 2 77630629 145701148 1 - by flanking markers 2 98037122 165313939 1 - by flanking markers 2 78321410 145903673 1 - by flanking markers 2 76539322 140636154 1 - by flanking markers RRID:RGD_1357984 1357985 LOU/Ins originated from Universite Catholique de Louvain. INSERM, C.H.U. Bichat-Claude Bernard, Paris, France inbred Unknown RRID:RGD_1357985 1357986 SS.LEW-(D1Uia8-D1Rat211)/Mco This strain was constructed from the progenitor strain SS.LEW-(D1Uia8-D1Rat18)/Mco by crossing the progenitor strain to SS rats to get F1 followed by F1 X F1 intercross to get F2 which was screened for the desired recombinants. Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown 17 1147796 1148037 1 - by flanking markers 1 35077728 35077968 1 - by flanking markers 1 33667777 33668017 1 - by flanking markers 1 31050840 31051081 1 - by flanking markers RRID:RGD_1357986 1357987 SS.LEW-(D1Uia8-D1Rat18)/Mco A 17 cM segment of chr 1 from Lewis which was obtained from Charles was introgressed into Dahl salt-sensitive strain which is an in-house colony. Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown 1 43747374 43747532 1 - by flanking markers 1 50297465 50297622 1 - by flanking markers 1 49454221 49454378 1 - by flanking markers 1 49268362 49268520 1 - by flanking markers RRID:RGD_1357987 1357988 SS.LEW-(D3Rat52-D3Rat17)/Ayd A segment of chromosome 3 was transferred from LEW into the SS background. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 3 14051872 121619110 1 - by flanking markers 3 19410399 133513825 1 - by flanking markers 3 14090411 127023997 1 - by flanking markers 3 18311454 121056321 1 - by flanking markers RRID:RGD_1357988 1357994 SHR/NCrl To Charles River from NIH in 1973 at F32. To N 1966 at F13 from Okamoto. Okamoto, Kyoto School of Medicine, 1963, from outbred Wistar Kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure; brother-sister mating with continued selection for spontaneous hypertension. Charles River Laboratories inbred Live Animals (as of 2020-01-23) RRID:RGD_1357994 1358112 WKY/NCrl Outbred Wistar stock from Kyoto School of Medicine to NIH in 1971, to Charles River in 1974 from NIH at F11 Charles River Laboratories inbred Unknown RRID:RGD_1358112 1358114 SS-Chr 5BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Live Animals; Cryopreserved Sperm RRID:RGD_1358114 1358150 SS.LEW-(D16Rat12-D16Chm23)/Ayd This congenic strain originated from a SS/Jr parental strain. Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 16 42656 350232 1 - by flanking markers 16 751266 1084414 1 - by flanking markers 16 756352 1090164 1 - by flanking markers 16 88524 380356 1 - by flanking markers RRID:RGD_1358150 1358151 FHH-Chr 8BN/Mcwi A FHH genomic background with a BN chromosome 8 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358151 1358152 SS-Chr 14BN/Mcwi A SS genomic background with a BN chromosome 14 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358152 1358153 COP/CrCrl Inbred strain is from Curtis in 1921 at Columbia University Institute for Cancer Research. To National Cancer Institute Animal Production Program (Cr). To Charles River from the National Cancer Institute in 1998. Charles River Laboratories inbred Unknown RRID:RGD_1358153 1358154 SS-Chr 3BN/Mcwi A SS genomic background with a BN chromosome 3 introgressed. PhysGen consomic Live Animals; Cryopreserved Sperm RRID:RGD_1358154 1358155 SS.LEW-(D10Rat119-D10Mgh1)(D16Rat21-D16Rat112)/Ayd This double congenic strain was constructed by using the SS/Jr strain as a donor strain to transfer regions (D10Rat119-D10Mgh1)and (D16Rat21-D16Rat112) from the LEW strain Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown RRID:RGD_1358155 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd Congenic strain was created by backcrossing congenic strain SS.MNS-(D2Mit6-D2Rat166)/Lt strain into the parental Dahl Salt-sensitive (SS) strain. Centre Hospitalier de L'Universite de Montreal (CHUM), Montreal, Quebec,Canada congenic Unknown 2 144136724 145774334 1 - by flanking markers 2 163731761 165386311 1 - by flanking markers 2 144313532 145975996 1 - by flanking markers 2 139096736 140708949 1 - by flanking markers RRID:RGD_1358156 1358157 FHH-Chr 7BN/Mcwi A FHH genomic background with a BN chromosome 7 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358157 1358158 FHH-Chr 16BN/Mcwi A FHH genomic background with a BN chromosome 16 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358158 1358159 FHH-Chr 6BN/Mcwi A FHH genomic background with a BN chromosome 6 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358159 1358160 SS.BN-(D8Rat163-D8Rat81)/Mcwi A SS genomic background with a majority BN chromosome 8 introgressed. The segment of chromosome 8 that caries the BN extends from D8Rat163-D8Rat81. PhysGen congenic Unknown 8 31508524 124926877 1 - by flanking markers 8 32911182 127854519 1 - by flanking markers 8 32888352 128653291 1 - by flanking markers 8 30188867 119698120 1 - by flanking markers RRID:RGD_1358160 1358161 SS.LEW-(D16Rat38-D16Chm66)/Ayd This congenic strain originated from a SS/Jr parental strain. Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 16 3080748 8612621 1 - by flanking markers 16 3405986 11276947 1 - by flanking markers 16 3439525 9316554 1 - by flanking markers 16 2995225 8336378 1 - by flanking markers RRID:RGD_1358161 1358162 SS-Chr 12BN/Mcwi A SS genomic background with a BN chromosome 12 introgressed. PhysGen consomic Live Animals RRID:RGD_1358162 1358163 SS-Chr 15BN/Mcwi A SS genomic background with a BN chromosome 15 introgressed. PhysGen consomic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1358163 1358164 FHH-Chr 17BN/Mcwi A FHH genomic background with a BN chromosome 17 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358164 1358165 SS.MNS-(D2Chm51-D2Rat341)/Ayd Congenic strain was created by backcrossing congenic strain SS.MNS-(D2Mit6-D2Rat166)/Ayd strain into the parental Dahl Salt-sensitive (SS) strain. Centre Hospitalier de L'Universite de Montreal (CHUM), Montreal, Quebec,Canada congenic Unknown 2 151616735 155664303 1 - by flanking markers 2 171854997 177018102 1 - by flanking markers 2 152460836 157650873 1 - by flanking markers 2 146368688 150090572 1 - by flanking markers RRID:RGD_1358165 1358166 SS.LEW-(D16Mit3-D16Rat112)/Ayd This congenic strain originated from a SS/Jr parental strain. Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 16 64718 47434384 1 - by flanking markers 16 773329 47069744 1 - by flanking markers 16 778415 47346612 1 - by flanking markers 16 110590 44236047 1 - by flanking markers RRID:RGD_1358166 1358167 SS.MNS-(D2Wox27-Adh1)/Ayd Congenic strain was created by backcrossing congenic strain SS.MNS-(D2Mit6-Adh1)/Lt strain into the parental Dahl Salt-sensitive (SS) strain. Centre Hospitalier de L'Universite de Montreal (CHUM), Montreal, Quebec,Canada congenic Unknown Adh1 2044 2 202186267 235811584 1 - by flanking markers 2 228956554 262102977 1 - by flanking markers 2 209489455 243562243 1 - by flanking markers 2 194352314 226808892 1 - by flanking markers RRID:RGD_1358167 1358168 SS.LEW-(D16Mit2-D16Chm23)/Ayd This congenic strain originated from a SS/Jr parental strain. Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 16 42656 4304517 1 - by flanking markers 16 751266 5038806 1 - by flanking markers 16 756352 5098704 1 - by flanking markers 16 88524 4227730 1 - by flanking markers RRID:RGD_1358168 1358169 SS.MNS-(D2Chm25-D2Rat131)/Ayd Congenic strain was created by backcrossing congenic strain SS.MNS-(D2Chm90-D2Wox37)/Lt strain into the parental Dahl Salt-sensitive (SS) strain. Centre Hospitalier de L'Universite de Montreal (CHUM), Montreal, Quebec,Canada congenic Unknown 2 172459883 179302663 1 - by flanking markers 2 199188066 206015340 1 - by flanking markers 2 179779225 186612024 1 - by flanking markers 2 166144095 172711135 1 - by flanking markers RRID:RGD_1358169 1358170 FHH-Chr 5BN/Mcwi A FHH genomic background with a BN chromosome 5 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358170 1358171 SS-Chr 17BN/Mcwi A SS genomic background with a BN chromosome 17 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358171 1358172 SS.MNS-(D2Chm25-Fgg)/Ayd Congenic strain was created by backcrossing congenic strain SS.MNS-(D2Mit6-Adh1)/Lt strain into the parental Dahl Salt-sensitive (SS) strain. Centre Hospitalier de L'Universite de Montreal (CHUM), Montreal, Quebec,Canada congenic Unknown Fgg 2613 2 172459883 174734594 1 - by flanking markers 2 199188066 201409143 1 - by flanking markers 2 179779225 181994523 1 - by flanking markers 2 166144095 168362325 1 - by flanking markers RRID:RGD_1358172 1358173 FHH-Chr 11BN/Mcwi A FHH genomic background with a BN chromosome 11 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358173 1358174 SS-Chr 19BN/Mcwi A SS genomic background with a BN chromosome 19 introgressed. PhysGen, Rat Resource and Research Center consomic Cryopreserved Sperm (as of 2021-05-07) RRID:RRRC_00601 1358175 FHH-Chr 20BN/Mcwi A FHH genomic background with a BN chromosome 20 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358175 1358176 FHH-Chr 18BN/Mcwi A FHH genomic background with a BN chromosome 18 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358176 1358177 SS.MNS-(D2Chm25-D2Mit14)/Ayd Congenic strain was created by backcrossing congenic strain SS.MNS-(D2Mit6-Adh1)/Lt strain into the parental Dahl Salt-sensitive (SS) strain. Centre Hospitalier de L'Universite de Montreal (CHUM), Montreal, Quebec,Canada congenic Unknown 2 172459883 197256313 1 - by flanking markers 2 199188066 224018437 1 - by flanking markers 2 179779225 204585731 1 - by flanking markers 2 166144095 189599348 1 - by flanking markers RRID:RGD_1358177 1358178 SS-Chr 10BN/Mcwi A SS genomic background with a BN chromosome 10 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358178 1358179 FHH-Chr 13BN/Mcwi A FHH genomic background with a BN chromosome 13 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1358179 1358180 FHH-Chr 19BN/Mcwi A FHH genomic background with a BN chromosome 19 introgressed. PhysGen, Rat Resource and Research Center consomic Cryopreserved Sperm (as of 2021-05-07) RRID:RRRC_00581 1358258 RCS/LavRrrc royal college of surgeons rat Originally developed before 1965 by Sidman from stock obtained from Sorsby of the Royal College of Surgeons, London. Then to University of California- San Francisco, School of Medicine, deposited to Rat Resource & Research Center. Retinal Degeneration Rat Model Resource , Rat Resource and Research Center inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-11-30) RRID:RRRC_00314 1358259 RCS-p+/LavRrrc This strain has homozygous wild type at the pink eye (p+) locus and homozygous for a deletion in the Mertk gene. Developed by intercrossing (brother x sister) two black-eyed p/+ rats from the RCS-p/+ strain. The black-eyed animals were tested for homozygous p locus and then backcrossed to the parental strain. Retinal Degeneration Rat Model Resource , Rat Resource and Research Center congenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-11-30) RRID:RRRC_00315 1358277 RCS-rdy+/LavRrrc Developed by crossing an inbred RCS (rdy/rdy) with a cesarian developed Fischer (+/+) rat (from Charles River). The normal rats(+/rdy) were backcrossed to the RCS and the procedure repeated. Retinal Degeneration Rat Model Resource , Rat Resource and Research Center congenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-07-16) RRID:RRRC_00317 1358278 RCS-rdy+p+/LavRrrc Developed by crossing a pink-eyed control(RCS-rdy+/Lav x black-eyed dystrophic(RCS-p+/Lav) The F12 progeny was backcrossed to RCS-rdy+/Lav. The strain is pigmented (p+) congenic control strain (rdy+, wild-type at the retinal dystrophy locus) for the pigmented RCS-p+ dystrophic (rdy-) strain Retinal Degeneration Rat Model Resource , Rat Resource and Research Center congenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2021-02-12) RRID:RRRC_00316 1358298 SD-Tg(Rho*P23H)1LavRrrc This transgenic strain carries a copy of mouse Rhodopsin gene with a proline to histidine substitution at codon 23 (c.68C>A). Retinal Degeneration Rat Model Resource ,Rat Resource and Research Center transgenic Live Animals (as of 2021-05-07) Rho 11239 RRID:RRRC_00639 1358299 SD-Tg(Rho*P23H)2Lav This transgenic strain carries a copy of mouse Rhodopsin gene with a proline to histidine substitution at codon 23 (c.68C>A). Retinal Degeneration Rat Model Resource transgenic Unknown RRID:RGD_1358299 1358300 SD-Tg(Rho*P23H)3Lav This transgenic strain carries a copy of mouse Rhodopsin gene with a proline to histidine substitution at codon 23 (c.68C>A). Retinal Degeneration Rat Model Resource ,Rat Resource and Research Center transgenic Unknown RRID:RRRC_00641 1358302 SD-Tg(Rho*S334X)3Lav This transgenic strain carries a mouse rhodopsin gene that bears a termination codon at residue 334, which encodes a C-terminal truncated opsin protein. Retinal Degeneration Rat Model Resource , Rat Resource and Research Center transgenic Unknown RRID:RRRC_00643 1358303 SD-Tg(Rho*S334X)4Lav This transgenic strain carries a mouse rhodopsin gene that bears a termination codon at residue 334, which encodes a C-terminal truncated opsin protein. Retinal Degeneration Rat Model Resource ,Rat Resource and Research Center transgenic Unknown RRID:RRRC_00645 1358304 SD-Tg(Rho*S334X)5Lav This transgenic strain carries a mouse rhodopsin gene that bears a termination codon at residue 334, which encodes a C-terminal truncated opsin protein. Retinal Degeneration Rat Model Resource transgenic Unknown RRID:RGD_1358304 1358305 SD-Tg(Rho*S334X)7Lav This transgenic strain carries a mouse rhodopsin gene that bears a termination codon at residue 334, which encodes a C-terminal truncated opsin protein. Retinal Degeneration Rat Model Resource transgenic Unknown RRID:RGD_1358305 1358306 SD-Tg(Rho*S334X)9Lav This transgenic strain carries a mouse rhodopsin gene that bears a termination codon at residue 334, which encodes a C-terminal truncated opsin protein. Retinal Degeneration Rat Model Resource transgenic Unknown RRID:RGD_1358306 1358632 MR/Har Maudsely reactive This strain has been selected for high open-field defecation (a test of emotional reactivity). The underlying genetic basis for this phenotype is not known. Originally selected by Broadhurst in 1954 for high open-field defacation (OFD) response in an open field. By Broadhurst to Harrington at the University of Northern Iowa at generation 25 in 1965. Center for Developmental and Health Genetics, Pennsylvania State University, Pennsylvania. Rat Resource and Research Center inbred Cryopreserved Embryo (as of 2019-02-20) RRID:RRRC_00691 1358633 MNRA/Har Originally selected by Broadhurst in 1954 for low open-field defacation (OFD) response in an open field. By Broadhurst to Harrington at the University of Northern Iowa at generation 25 in 1965. Center for Developmental and Health Genetics, Pennsylvania State University, Pennsylvania inbred Unknown RRID:RGD_1358633 1358918 W-Plp1md/Nya W-Plp1md Wistar rats were received in 1957 from Walter Reed Army Medical Center. In 1977, three ofsprings exhibited body tremor. Two of these had hydrocephalus and the brain of the third was normal. The mother rat and four of its clinically mormal youngs along with three adult males were breed as nuclear breeders. Division of Laboratories and Research, New York State Department of Health, Albany, New York mutant Unknown Plp1|Plp1md 3354|12802346 X 124488627 124503639 1 - by flanking markers X 107379831 107394881 1 - by flanking markers X 107494326 107511355 1 - by flanking markers X 100184039 100201035 1 - by flanking markers RRID:RGD_1358918 1358919 F344/Seac Inbred strain originated from F344 rats SEAC Yoshitomi Co., Fukuoka, Japan inbred Unknown RRID:RGD_1358919 1358921 WF.DA-(D19Mit1-D19Mit6)/Kop Congenic strain originated from a parental DA/Slc strain. kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cancer Nqo1 2503 19 26536747 41612881 1 - by flanking markers 19 35433730 54715514 1 - by flanking markers 19 24455726 43907843 1 - by flanking markers 19 24817978 39654489 1 - by flanking markers RRID:RGD_1358921 1358922 BB.WOKW-(D4Got41-Fabp1)/K Congenic strain originated from a BB/OK parental strain. Dept. of Laboratory Animal Science, Medical Faculty, University of Greifswald, Karlsburg, Germany congenic Unknown Fabp1 2590 4 60262965 104415981 1 - by flanking markers 4 60179409 163844105 1 - by flanking markers 4 60439127 99066957 1 - by flanking markers 4 61697658 103194791 1 - by flanking markers RRID:RGD_1358922 1358923 LE-Mbpmd A spontaneous tremor rat was originated from in-house breeding colony , after purchased from Charles River Laboratory 12 years earlier, at McMaster University Central Animal Facility, Hamilton, Ontario, Canada. 10-12 days old rats had tremors that were followed by ataxia, hind limb paresis, episodes of immobility, and seizures by 5-14 weeks. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada mutant Unknown Mbp|Mbpmd 3054|12802351 18 78943608 79057329 1 - by flanking markers 18 78385304 78504226 1 - by flanking markers 18 79326738 79437310 1 - by flanking markers 18 75855878 75966404 1 - by flanking markers RRID:RGD_1358923 1358989 WKY.SHR-(D2Rat174-D2Rat28)(D2Rat161-D2Rat185) This congenic substrain was contructed by repeated backcrossing of congenic strain WKY.SHR-(D2Rat174-D2Rat185) to parental strain WKY/NCrl Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown RRID:RGD_1358989 1358990 DA.F344-(D10Mit9-D10Rat24)/Nsi Congenic strain created by backcrossing DA/BklArbNsi and F344/Hsd North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030 congenic Unknown 10 31931622 79229233 1 - by flanking markers 10 31740635 78195122 1 - by flanking markers 10 31919397 78343192 1 - by flanking markers 10 31224026 75632053 1 - by flanking markers RRID:RGD_1358990 1358991 F344.HTX-(D11Rat4-D11Arb4)/Hcj Congenic strain originated from F344/NHsd parental strain bred to HTX/Hcj Department of Pharmacology, University of Florida, Gainesville congenic Unknown 11 64573222 68235010 1 - by flanking markers 11 66731054 72739915 1 - by flanking markers 11 65352097 69649936 1 - by flanking markers 11 62790342 66422377 1 - by flanking markers RRID:RGD_1358991 1358992 SHR.WKY-(D2Rat40-D2Rat50) Congenic strains were constructed by repeated backcross of an (SHR/NCrl x WKY/NCrl)F1 to the SHR/NCrl recipient strain with selection for chromosome 2 markers Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown 2 163154227 200390471 1 - by flanking markers 2 189197858 227035367 1 - by flanking markers 2 169852670 207612467 1 - by flanking markers 2 157142078 192625452 1 - by flanking markers RRID:RGD_1358992 1358993 WKY.SHR-(D2Rat161-D2Rat185) This congenic substrain was contructed by repeated backcrossing of congenic strain WKY.SHR-(D2Rat174-D2Rat185) to parental strain WKY/NCrl Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown 2 118264490 238140155 1 - by flanking markers 2 138120195 264423808 1 - by flanking markers 2 118446646 245893748 1 - by flanking markers 2 114837527 229059787 1 - by flanking markers RRID:RGD_1358993 1358994 SHR.WKY-(D2Rat161-D2Rat241) This congenic substrain was constructed by repeated backcrossing the congenic strain SHR.WKY-(D2Rat10-D2Mgh13) congenic strain to the parental strain SHR/NCrl Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown 2 118264490 217985582 1 - by flanking markers 2 138120195 242993417 1 - by flanking markers 2 118446646 118446793 1 - by flanking markers 2 114837527 114837675 1 - by flanking markers RRID:RGD_1358994 1358995 F344.OLETF-(D1Rat166-D1Rat90)/Tj Congenic strain originated from backcrossing parental F344/Crlj and OLETF/Otk animals. Laboratory of Animal Breeding and Genetics, Kyoto University, Sakyoku, Kyoto, Japan, National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 1 255026793 267111153 1 - by flanking markers 1 276721459 289137268 1 - by flanking markers 1 269279863 281795785 1 - by flanking markers 1 248393012 259647894 1 - by flanking markers RRID:RGD_1358995 1358996 SHR.WKY-(D2Rat10-D2Mgh13) This congenic strain carries a WKY/NCrl chromosome 2 segment transferred to a SHR/NCrl background Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown 2 35874553 244809764 1 - by flanking markers 2 54092967 270992875 1 - by flanking markers 2 34967269 252466565 1 - by flanking markers 2 36023184 235501121 1 - by flanking markers RRID:RGD_1358996 1358997 WKY.SHR-(D2Rat241-D2Rat185) This congenic substrain was contructed by repeated backcrossing of congenic strain WKY.SHR-(D2Rat174-D2Rat185)/NCrl to parental strain WKY/NCrl Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown 2 217985399 238140155 1 - by flanking markers 2 242993235 264423808 1 - by flanking markers 2 245893572 245893748 1 - by flanking markers 2 229059610 229059787 1 - by flanking markers RRID:RGD_1358997 1358998 BUF/NHsd Heston 1946 from Buffalo stock of H. Morris. To NIH in 1950 at F10. These were bought from Harlan. Harlan inbred Unknown RRID:RGD_1358998 1358999 WKY.SHR-(D2Rat174-D2Rat28) This congenic substrain was contructed by repeated backcrossing of congenic strain WKY.SHR-(D2Rat174-D2Rat185) to parental strain WKY/NCrl Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown 2 60124623 107574826 1 - by flanking markers 2 83930202 126824737 1 - by flanking markers 2 60746052 107083569 1 - by flanking markers 2 59744817 104815148 1 - by flanking markers RRID:RGD_1358999 1359000 DA.F344-(D10Arb27-D10Rat6)/Nsi Congenic strain created by backcrossing DA/BklArbNsi and F344/Hsd North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030 congenic Unknown 10 69160380 106310957 1 - by flanking markers 10 67971352 104746310 1 - by flanking markers 10 68305037 105078045 1 - by flanking markers 10 65927233 101436010 1 - by flanking markers RRID:RGD_1359000 1359001 WKY.SHR-(D2Rat42-D2Rat139) Congenic strains were constructed by repeated backcross of an (SHR/NCrl x WKY/NCrl)F1 to the WKY/Crl recipient strain with selection for chromosome 2 SHR markers Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown 2 180768203 232533087 1 - by flanking markers 2 207416346 258769070 1 - by flanking markers 2 188013923 240243929 1 - by flanking markers 2 174110900 223490532 1 - by flanking markers RRID:RGD_1359001 1359002 NTac:WKY The Taconic Wistar Kyoto rat was received from the NIH Animal Genetic Resource in 1974 at F10. The NIH-stock was obtained in 1971 as non-inbred Wistar stock from the Kyoto School of Medicine. Cesarean derived in 1982, Taconic's WKY is randomly bred in a closed colony. Taconic outbred Unknown RRID:RGD_1359002 1359003 LEW/Jr This strain is maintained by Dr. J Rapp at the Medical College of Ohio (Toledo), USA. Medical College of Ohio, Toledo, Ohio, USA inbred Unknown RRID:RGD_1359003 1359004 DA.F344-(D10Mit9-D10Rat11)/Nsi Congenic strain created by backcrossing DA/BklArbNsi and F344/Hsd North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030 congenic Unknown 10 31931622 100633982 1 - by flanking markers 10 31740635 99184250 1 - by flanking markers 10 31919397 99492409 1 - by flanking markers 10 31224026 96121100 1 - by flanking markers RRID:RGD_1359004 1359005 SHR.WKY-(D2Rat15-D2Rat50) This congenic substrain was constructed by repeated backcrossing the congenic strain SHR.WKY-(D2Rat10-D2Mgh13) to parental strain SHR/NCrl Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown 2 46251938 200390471 1 - by flanking markers 2 66171293 227035367 1 - by flanking markers 2 47783949 207612467 1 - by flanking markers 2 47137898 192625452 1 - by flanking markers RRID:RGD_1359005 1359006 WKY.SHR-(D2Rat27-D2Rat243) This congenic substrain was contructed by repeated backcrossing of congenic strain WKY.SHR-(D2Rat174-D2Rat185)/NCrl to parental strain WKY/NCrl Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown 2 96481750 221307793 1 - by flanking markers 2 116297660 248110514 1 - by flanking markers 2 96556622 228759752 1 - by flanking markers 2 94359407 212719943 1 - by flanking markers RRID:RGD_1359006 1359007 WKY.SHR-(D2Rat174-D2Rat62) This congenic substrain was contructed by repeated backcrossing of congenic strain WKY.SHR-(D2Rat174-D2Rat185)/NCrl to parental strain WKY/NCrl Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown 2 60124623 228664122 1 - by flanking markers 2 83930202 254867363 1 - by flanking markers 2 60746052 236318668 1 - by flanking markers 2 59744817 219753474 1 - by flanking markers RRID:RGD_1359007 1359008 F344.HTX-(D11Rat4-D11Arb4)(D17Rat23-D17Rat154)/Hcj Double congenic strain originated from a cross between single congenic strains F344.HTX-(D11Rat4-D11Arb4)/Hcj and F344.HTX-(D17Rat23-D17Rat154)/Hcj. Department of Pharmacology, University of Florida, Gainesville congenic Unknown RRID:RGD_1359008 1359009 WKY.SHR-(D2Rat174-D2Rat185) Congenic strains were constructed by repeated backcross of an (SHR/NCrl x WKY/NCrl)F1 to the WKY/Crl recipient strain with selection for chromosome 2 SHR markers Dept Pharmacology, Univ. of California San Diego, La Jolla, CA USA congenic Unknown 2 60124623 238140155 1 - by flanking markers 2 83930202 264423808 1 - by flanking markers 2 60746052 245893748 1 - by flanking markers 2 59744817 229059787 1 - by flanking markers RRID:RGD_1359009 1359010 WF.BBDR-ART2a/Wor Wistar Furth Congenic strain created by backcrossing WF strain to BBDR strain which are RT1 u/u , ART2a. University of Massachusetts Medical School,Department of Pathology 55 Lake Avenue Worcester, MA 01605 congenic Unknown RRID:RGD_1359010 1547865 FHH-Chr 3BN/Mcwi A FHH genomic background with a BN chromosome 3 introgressed. PhysGen consomic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1547865 1547866 F344/Jcl Inbred strain originated from F344 CLEA Japan, Inc inbred Live Animals (as of 2021-04-22) RRID:RGD_1547866 1547867 FHH-Chr 4BN/Mcwi A FHH genomic background with a BN chromosome 4 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1547867 1547868 FHH-Chr 2BN/Mcwi A FHH genomic background with a BN chromosome 2 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1547868 1547869 ACI/Eur August x Copenhagen Irish Curtiss and Dunning 1926 at the Columbia University Institute for Cancer Research. To Heston 1945 at F30, to National Institutes of Health 1950 at F41. Subsequent sublines from Dunning or NIH Department of Pediatric Surery, Erasmus Medical Center, Rotterdam, Netherlands inbred Unknown RRID:RGD_1547869 1547870 FHH-Chr 14BN/Mcwi A FHH genomic background with a BN chromosome 14 introgressed. PhysGen consomic Live Animals RRID:RGD_1547870 1547871 ACI.FHH-(D1Rat324-D1Rat156)/Eur Congenic strain created from backcrossing ACI/Eur and FHH/Eur parental strains. Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Unknown 1 229301063 253410500 1 - by flanking markers 1 251109240 279213254 1 - by flanking markers 1 243853559 243853760 1 - by flanking markers 1 223506828 223507030 1 - by flanking markers RRID:RGD_1547871 1547872 FHH-Chr XBN/Mcwi FHH-Chr XBN/Mcwi A FHH genomic background with a BN chromosome X introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1547872 1547873 FHH-Chr 15BN/Mcwi A FHH genomic background with a BN chromosome 15 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1547873 1547874 FHH-Chr YBN/Mcwi FHH-Chr YBN/Mcwi A FHH genomic background with a BN chromosome Y introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1547874 1547875 ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur Congenic strain originated from backcrossing ACI/Eur and FHH/Eur parental strains. Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Unknown 17 31007408 69257442 1 - by flanking markers 17 27537443 67580933 1 - by flanking markers 17 25609692 65831023 1 - by flanking markers 17 24982652 58691962 1 - by flanking markers RRID:RGD_1547875 1547876 FHH-Chr 10BN/Mcwi A FHH genomic background with a BN chromosome 10 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1547876 1549794 SS.LEW-(D2Rat199-D2Mco17)/Ayd Congenic strain was created from a SS/Jr parental strain Research Centre Hospitalier de l'Universite de Montreal, Quebec, Canada congenic Unknown 2;4 41032071;157987925 76020140;157987994 1 - by flanking markers;1 - by flanking markers 2;4 60242455;221211532 95618891;221211601 1 - by flanking markers;1 - by flanking markers 2;4 41179255;154125111 75896315;154125180 1 - by flanking markers;1 - by flanking markers X;2;4 46603085;41243963;154786975 46603120;74997963;154787045 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers RRID:RGD_1549794 1549795 SS.LEW-(D2Rat199-D2Rat143)/Ayd Congenic strain was created from a SS/Jr parental strain Research Centre Hospitalier de l'Universite de Montreal, Quebec, Canada congenic Unknown 2 41032071 106236206 1 - by flanking markers 2 60242455 125885146 1 - by flanking markers 2 41179255 106156987 1 - by flanking markers 2 41243963 103519040 1 - by flanking markers RRID:RGD_1549795 1549796 BN/2Hok Transferred from Hokkaido University, Chromosome Research Unit, 1987 F16 National BioResource Project for the Rat in Japan coisogenic Live Animals; Cryopreserved Embryo RRID:RGD_1549796 1549797 BUF.ACI-(D16Rat31-D16Arb1)/Ncc This congenic strain in the BUF background that has homozygous ACI chr16 was developed by the speed congenic method. National BioResource Project for the Rat in Japan congenic Unknown 16 8340080 8340453 1 - by flanking markers 16 11019972 11020174 1 - by flanking markers 16 9055590 9055792 1 - by flanking markers 16 8082906 8083107 1 - by flanking markers RRID:RGD_1549797 1549798 BB.PVG-RT1u/a/Tky A congenic strain with the genetic background of the BB/WorTky strain (RT1.Bu,Du ) onto which the MHC locus of PVG.R23 strain (RT1.B,D) has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Immunology RRID:RGD_1549798 1549799 BB.SHR-(D6Rat184-D6Rat3)/K Congenic BB.6S rats were established by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats in 2000. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Metabolism 6 121381065 145279536 1 - by flanking markers 6 130448688 154782041 1 - by flanking markers 6 121224054 145868598 1 - by flanking markers 6 116506292 138922889 1 - by flanking markers RRID:RGD_1549799 1549800 BN/KunKtsSlc Kitasato University School of Medicine to Slc (2001) This strain is no longer available from NBRP-Rat (June 2022). mutant Unknown (as of 2022-06-09) Metabolism RRID:RGD_1549800 1549801 BN/Seac Seac Yoshitomi, LTD, Fukuoka, Japan Seac Yoshitomi, LTD, Fukuoka, Japan, National BioResource Project for the Rat in Japan inbred Cryopreserved Sperm Behavior; Ophthalmology RRID:RGD_1549801 1549802 BN/1Hok Transferred from Hokkaido University, Chromosome Research Unit, 1987 F15 National BioResource Project for the Rat in Japan coisogenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1549802 1549803 ACI-Lystbg-Kyo/Kyo Spontaneous mutation from ACI/NKyo inbred at Kyoto University in 1999. National BioResource Project for the Rat in Japan coisogenic Cryopreserved Embryo; Cryopreserved Sperm Hematology RRID:RGD_1549803 1549804 BUF/NacJcl CLEA Japan, Inc., Tokyo Japan Carcinogenesis Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan inbred Unknown RRID:RGD_1549804 1549805 BUF.Cg-Foxn1rnu/Mna BUF/Mna, NN1H-Rnu/Rnu National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Urology RRID:RGD_1549805 1549806 BUF.ACI-(D3Rat56-D3Rat83)/Ncc This strain was produced by speed congenic methods in which several generations of backcrossing were carried out in order to transfer the ACI chromosome 3 region into the BUF/Nac background recipient strain Carcinogenesis Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan, National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cancer 3 3577905 42635088 1 - by flanking markers 3 2612834 52104192 1 - by flanking markers 3 2631421 46996487 1 - by flanking markers 3 8227194 45391731 1 - by flanking markers RRID:RGD_1549806 1549808 SS.LEW-(Prlr-D2Rat143)/Ayd Congenic strain was created from a SS/Jr parental strain Research Centre Hospitalier de l'Universite de Montreal, Quebec, Canada congenic Unknown Prlr 3407 2 59507966 106236206 1 - by flanking markers 2 84360850 125885146 1 - by flanking markers 2 60131410 106156987 1 - by flanking markers 2 59134147 103519040 1 - by flanking markers RRID:RGD_1549808 1549809 BN/KtsSlc Kitasato University School of Medicine to Slc (2002) This strain is no longer available from NBRP-Rat (June 2022). inbred Unknown (as of 2022-06-09) Immunology RRID:RGD_1549809 1549810 AI/Msik amelogenesis imperfecta rat This strain is originated from female rats showing white incisors of an SD rat colony purchased from Charles River Japan, Inc. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Dentistry RRID:RGD_1549810 1549811 ACI/NJcl ACI/N rats that were purchased from CLEA Japan, Inc., Tokyo Japan. Carcinogenesis Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; National BioResource Project for the Rat in Japan inbred Unknown RRID:RGD_1549811 1549813 F344.ACI-Lmx1aqc/Kyo Congenic strain created by backcrosses between ACI/Pas and F344/NSlc strains. The short-tail mutation, “queue courte” in French (with qc as a symbol), occurred spontaneously in 1994, in the ACI/Pas inbred strain of rat maintained at the Institute Pasteur (Paris, France), and was kept segregating in this stock. Since importation into the Institute of Laboratory Animals at Kyoto University, it has been maintained as a congenic strain F344.ACI-qc using F344/NSlc as an inbred partner. Institute of Laboratory Animals at Kyoto University, Japan, National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2020-11-12) Apoa2|Selp|Lmx1a 2131|3656|1304784 13 79886614 87116372 1 - by flanking markers 13 87308435 94225670 1 - by flanking markers 13 82428914 89598805 1 - by flanking markers 13 76476229 83646358 1 - by flanking markers RRID:RGD_1549813 1554301 WKHA/Bord Strain was originated from WHHA/Edh at the University of Vermont College of Medicine Universite Victor Segalen Bordeaux 2, Bordeaux cedex, France inbred Unknown RRID:RGD_1554301 1554302 HOB-Unc5chob/Snk hobble rat Homozygous hobble rats that were taken from the inbred hobble rat colony. National BioResource Project for the Rat in Japan mutant Unknown Unc5c|Unc5chob 735109|12802353 2 239365109 239721231 1 - by flanking markers 2 265573406 265926229 1 - by flanking markers 2 247045813 247397483 1 - by flanking markers 2 230180353 230535219 1 - by flanking markers RRID:RGD_1554302 1554303 CVD/Opu Cerebellar vermis defect rat Originated from a colony of Lewis rats that were spontaneously ataxic. Maintained by brother-sister mating with phenotypically normal littermates. Department of Veterinary Pathology, Osaka Prefecture University, Sakai, Osaka, Japan mutant Unknown Unc5c 735109 2 239365109 239721231 1 - by flanking markers 2 265573406 265926229 1 - by flanking markers 2 247045813 247397483 1 - by flanking markers 2 230180353 230535219 1 - by flanking markers RRID:RGD_1554303 1554304 GAERS/Mave Genetic Absence Epilepsy Rats from Strasbourg 30% of the Wistar rats from the initial breeding colony in Strasbourg had spontaneous spike and wave discharges (SWDs) which were bilateral and synchronous over the cerebral cortex. Breeders with SWDs were selected and used for breeding. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Neurobiology RRID:RGD_1554304 1554305 DA-Tg(CAG-lacZ)30Jmsk lacZ cDNA was inserted in the EcoRI site of the pCAGGS expression vector. This DNA was microinjected into the DA/Crlj. The expression of the transgene was determined by beta-gal staining. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Development RRID:RRRC_00295 1554306 GK/Slc Goto Kakizaki Rat Spontaneous mutant GK rat which were obtained from Japan SLC, Inc. National BioResource Project for the Rat in Japan mutant Live Animals Diabetes Obesity RRID:RGD_1554306 1554307 W-Tg(LAC3)Ys These transgenic rats are produced by the intracytoplasmic sperm injection (ICSI) using a Piezo-driven micromanipulator. This tranasgenic line carries a single copy of 210 kb YAC gene that codes for human lactalbumin and thymidine kinase. YS New Technology Institute, Tochigi, Japan transgenic Unknown RRID:RGD_1554307 1554308 Gunn-Ugt1a1j/Slc Gunn Segregated inbred Gunn rat which were obtained from Japan SLC, Inc. National BioResource Project for the Rat in Japan segregating_inbred Live Animals Neurobiology; Metabolism Ugt1a1j 13432064 RRID:RGD_1554308 1554309 W-Tg(CAG-GFP)184Ys These transgenic rats are produced by the intracytoplasmic sperm injection (ICSI) using a Piezo-driven micromanipulator. National BioResource Project for the Rat in Japan, Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm Development RRID:RRRC_00259 1554310 DA-Tg(CAG-lacZ)19Jmsk lacZ cDNA was inserted in the EcoRI site of the pCAGGS expression vector. This DNA was microinjected into the DA/Crlj. The expression of the transgene was determined by beta-gal staining. National BioResource Project for the Rat in Japan, Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm Development RRID:RRRC_00294 1556748 F344/Snk Medicinal Safety Research Laboratories, Sankyo Co. Ltd., Shizuoka, Japan Medicinal Safety Research Laboratories, Sankyo Co. Ltd., Shizuoka, Japan inbred Unknown RRID:RGD_1556748 1558660 SHRSP/Tkyo Substrain of SHRSP rats maintained at International Medical Center of Japan, Tokyo Department of Gene Diagonostics and Therapeutics, Research Institute, International Medical Center of Japan, Tokyo, Japan inbred Unknown RRID:RGD_1558660 1558661 WKY/Tkyo Substrain of WKY rats maintained at International Medical Center of Japan, Tokyo Department of Gene Diagonostics and Therapeutics, Research Institute, International Medical Center of Japan, Tokyo, Japan inbred Unknown RRID:RGD_1558661 1558662 SHR/Tkyo Substrain of SHR rats maintained at International Medical Center of Japan, Tokyo Department of Gene Diagonostics and Therapeutics, Research Institute, International Medical Center of Japan, Tokyo, Japan inbred Unknown RRID:RGD_1558662 1559030 LEC-Tg(ATP7B)Tohm A 4.5 kb fragment of human ATP7B cDNA was blunt-end ligated into the pCXN2 vector that contained the CAG promoter to generate pCXN2ATP7B which was microinjected into the pronuclei of LEC/Crlj. The transgenic founders were identified by the PCR analysis of the tail-DNA. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo; Cryopreserved Sperm Cancer RRID:RGD_1559030 1559031 NE/Mave The control strain of GAERS, free of any spontaneous spike and wave discharges. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Neurobiology RRID:RGD_1559031 1559032 SS.LEW-(D17Rat65-D17Chm2)/Ayd This congenic substrain contains a LEW/Crlc chromosome 17 segment transferred to the SS/Jr recipient strain; derived by crossing congenic strain SS.LEW-(D17Rat65-Prl) with SS/Jr, F2 animals were screened with D17Rat65 and Prl to identify regions with crossovers within this chromosome 17 segment Research Centre, Centre Hosp Univ Montreal, Quebec, Canada congenic Unknown 17 82247891 93930006 1 - by flanking markers 17 76483116 88435496 1 - by flanking markers 17 74823053 86731080 1 - by flanking markers 17 70973784 82479847 1 - by flanking markers RRID:RGD_1559032 1559033 SS.LEW-(D17Rat65-Prl)/Ayd This congenic strain contains a LEW/Crlc chromosome 17 segment transferred to the SS/Jr recipient strain Research Centre, Centre Hosp Univ Montreal, Quebec, Canada congenic Unknown Prl 3403 17 44699101 93930006 1 - by flanking markers 17 41720751 88435496 1 - by flanking markers 17 39814236 86731080 1 - by flanking markers 17 37859999 82479847 1 - by flanking markers RRID:RGD_1559033 1559034 SS.LEW-(D17Chm14-D17Rat97)/Ayd This congenic substrain contains a LEW/CrlBR chromosome 17 segment transferred to the SS/Jr recipient strain; derived by crossing congenic strain SS.LEW-(D17Rat65-Prl) with SS/Jr, F2 animals were screened with D17Rat65 and Prl to identify regions with crossovers within this chromosome 17 segment Research Centre, Centre Hosp Univ Montreal, Quebec, Canada congenic Unknown 17 73041111 80182186 1 - by flanking markers 17 60264084 74265481 1 - by flanking markers 17 58467778 72580782 1 - by flanking markers 17 62109333 68784138 1 - by flanking markers RRID:RGD_1559034 1559035 SS.LEW-(D17Chm14-D17Rat181)/Ayd This congenic strain contains a LEW/Crlc chromosome 17 segment transferred to the SS/Jr recipient strain Research Centre, Centre Hosp Univ Montreal, Quebec, Canada congenic Unknown 17 38257211 80182186 1 - by flanking markers 17 35100574 74265481 1 - by flanking markers 17 33208959 72580782 1 - by flanking markers 17 31896010 68784138 1 - by flanking markers RRID:RGD_1559035 1559036 LEW/Jms Lewis rats from Tokyo Medical Insitute to Seiwa Institute of Experimental Animals, Hydrocephalus was found the rats at F27 in 1980, these were sent to Dr. Yasutaka Noda at Center for Animal Experiments, Kurume University, The hydrocephalus rat strains have been maintained out by selective breeding. National BioResource Project for the Rat in Japan, Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-02-01) RRID:RRRC_00054 1559037 SS.LEW-(D17Chm9-D17Rat97)/Ayd This congenic substrain contains a LEW/Crlc chromosome 17 segment transferred to the SS/Jr recipient strain; derived by crossing congenic strain SS.LEW-(D17Rat65-Prl) with SS/Jr, F2 animals were screened with D17Rat65 and Prl to identify regions with crossovers within this chromosome 17 segment Research Centre, Centre Hosp Univ Montreal, Quebec, Canada congenic Unknown 17 73041111 83074398 1 - by flanking markers 17 60264084 77361330 1 - by flanking markers 17 58467778 75705622 1 - by flanking markers 17 62109333 71774817 1 - by flanking markers RRID:RGD_1559037 1559039 ODS/Shi Osteogenic disorder Shionogi Dr. Susumu Makino and his colleagues found several animals that had gait abnormalities among Wistar rats maintained at Shionogi Co. They named these animals osteogenic disorder (OD) rats because they exhibited prominent bone and joint abnormalities and systemic bleeding. Subsequent studies revealed that these symptoms were derived from an ascorbic acid (vitamin C) deficiency arising from defective gulonolactone oxidase (GLO) activity. This characteristic was confirmed to be the result of a mutation involving the autosomal single recessive gene od. Scurvy due to L-gulonolactone oxidase deficincy; phenotype normalizes if supplied with ascorbic acid 300mg/kg/d. od/od rats are more susceptible to dental caries as compared with +/+ rats, in only amoun parous females. Shionogi & Co., Ltd. Japan mutant Unknown RRID:RGD_1559039 1559040 MD/Tama myelin deficient rat X-linked mutant of the Wistar rat. National BioResource Project for the Rat in Japan mutant Live Animals Neurobiology; Development RRID:RGD_1559040 1559041 SHRSP/Ngsk Substrain of SHRSP developed by Prof. Okamoto at Kinki University, Japan in 1980. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Neurobiology; Cardio Hypertension; Osteosis RRID:RGD_1559041 1559042 SHR/Nig Originated in the SHR given from Prof. Okamoto at Kinki University, Japan in 1976. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension; Pharmacology RRID:RGD_1559042 1559043 MV/Opu myelin vacuolation rat The myelin vacuolation rats showing body tremor were found in an outbred colony of Sprague-Dawley rats at Osaka Osaka Prefecture University in 1999. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Neurobiology Atrnmv 40902835 3 118539268 118701177 1 - by flanking markers 3 129934303 130067267 1 - by flanking markers 3 123434409 123567922 1 - by flanking markers 3 118110320 118244326 1 - by flanking markers RRID:RGD_1559043 1559044 SS.SR-(D3Mco19-D3Mco5)/Jr A region of chr 3 which contains the Edn3 gene was introgressed into the SS rats Medical College of Ohio, Toledo, Ohio, USA congenic Unknown Edn3 2534 7;3 23312460;147799021 23312636;167653069 1 - by flanking markers;1 - by flanking markers 7;3 27325365;158391833 27325541;183008351 1 - by flanking markers;1 - by flanking markers 3;7 153327515;27206010 153327695;27206186 1 - by flanking markers;1 - by flanking markers 3;7 145871677;21089863 145871858;21090040 1 - by flanking markers;1 - by flanking markers RRID:RGD_1559044 1559045 LEW/Crlc LEW substrain obtained from Charles River Laboratories, La Salle, Quebec, Canada Charles River Laboratories, La Salle, Quebec, Canada inbred Unknown RRID:RGD_1559045 1559046 SHR-Chr YW/K Consomic SHR rats were established by crossing of SHR females and one wild rat male captured in northern part of Germany. Male hybrids were repeatedly backcrossed onto SHR females replacing the chromosome Y of SHR/Mol by that of wild rats in 1996. National BioResource Project for the Rat in Japan consomic Unknown RRID:RGD_1559046 1559047 SHRSP/Ezo Substrain of SHRSP maintained at Hokkaido University School of Medicine, Sapporo, Japan National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Neurobiology; Cardio Hypertension RRID:RGD_1559047 1559048 SHR.ODS-Gulood/Shi A congenic strain developed from a recipient, SHR and a donor, ODS. The first generation was backcrossed to SHR and these rats were genotyped and the heterozygous rats were backcrossed to SHR to generate the congenics. Introduced to Nagoya University in 1995. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension; Osteosis Gulo 620701 RRID:RGD_1559048 1566430 SimTac:LE Taconic Long Evans rats originated with Drs. Long and Evans in 1915 by a cross of several Wistar Institute white females with a wild grey male. Rederived in 1975 by Simonsen Laboratories from stock obtained from the University of California at Berkeley in 1949. Derived by Taconic in August 1998. Like all Taconic outbred rats, a monogamous mating system is used to maximize the heterozygosity of the stock. Taconic outbred Unknown RRID:RGD_1566430 1566431 BN/MolTac The BN/MolTac arrived at M&B A/S in 1993 at F90 from the Zentralinstitut f?r Versuchstierzucht, Hannover, Germany (Han). It was rederived at Taconic, USA in 2003. Taconic inbred Unknown RRID:RGD_1566431 1566432 WKY/NMolTac Wistar Kyoto The inbred Wistar Kyoto rat was received at Taconic from M&B A/S in 1998 at F61. M&B (formerly Mollegaard) received the strain from the NIH Animal Genetic Resource in 1975 at F13. The NIH-stock was obtained in 1971 as non-inbred Wistar stock from the Kyoto School of Medicine. Cesarean derived in 1999, Taconics Foundation Colony of inbred WKYs is maintained in a plastic-film gnotbiotic isolator. Breeders from the FC are regularly transferred to Taconics WKY Production Colony which is maintained in an MPF Barrier Unit. Taconic inbred Unknown RRID:RGD_1566432 1566433 HanTac:WH In 1989 RCC Ltd. of Switzerland obtained 156 breeding pairs of Wistar Hannovers from Dr. Willy Heine, Zentralinstitut f?r Versuchstierzucht (ZfV), Hannover, Germany. The stock was hysterectomy derived at RCC in 1989. Genetic drift in RCC?s colony of Wistar Hannovers is minimized through the use of the Poiley rotational breeding system and revitalization of the stock with cryopreserved embryos (most recent revitalization completed in 1998).Each Member of GALAS obtained in excess of fifty (50) Wistar Hannover breeders from RCC in late 1998. The line was cesarean derived in 1999 and Taconic replaced its former WH stock with the GALAS Wistar Hannover rat in June 2000. Taconic outbred Unknown RRID:RGD_1566433 1566434 NTac:SHR Taconics original SHR breeding stock was obtained in 1972 at F35 from the NIH Animal Genetic Resource. The NIH colony was established with rats from Okamoto in 1966 at F13 (Okamoto, Kyoto School of Medicine, from Wistar Kyoto outbred stock). Cesarean derived in 1984, Taconics SHR is randomly bred in a closed colony. Taconic outbred Unknown RRID:RGD_1566434 1566437 SS-Chr XBN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_1566437 1566438 DA/MolTac Developed at the Agricultural Research Council, Institute of Animal Physiology, Cambridge, UK; it then went to the Centralinstitut f?r Versuchstierzucht, Hannover, Germany (Han). From Han to M&B in 1990. Inbreeding F + 17 (February 2000). Rederived at Taconic, USA in 2004. Taconic inbred Unknown RRID:RGD_1566438 1566439 F344/NTac Axenic breeders were obtained at F143 by Taconic in 1984 from the NIH Animal Genetic Resource. Origin of the strain is as follows: to NIH in 1951 from Heston; to Heston in 1949 from Curtis, Columbia University Institute for Cancer Research. To preserve genetic continuity, Taconics F344 foundation colony is maintained in gnotobiotic isolators and the strain is periodically reestablished with breeding pairs from NIH. Taconic inbred Unknown RRID:RGD_1566439 1566440 NTac:SD Taconic SD rats were first obtained in 1970 from the NIH Animal Genetic Resource. The NIH stock originated from Sprague Dawley, Inc. in 1945 and has since been maintained as an outbred closed colony. To maintain genetic continuity with the SDN:SD strain of NIH, Taconic continually receives axenic breeder stock from the NIH Animal Genetic Resource for systematic introduction into Taconics production colonies. Taconic outbred Unknown RRID:RGD_1566440 1566443 LEW/MolTac Lewis Scripps Clinic, La Jolla, California to the University of Pennsylvania; to Simonsen Laboratories in 1966 at F20; to the Institute of Pathological Anatomy, University of Copenhagen, Denmark in 1973 at F28. The Lewis rat was obtained from the University of Copenhagen by M&B in 1977, and was received at Taconic, USA in 2002, where it was rederived. Taconic inbred Unknown RRID:RGD_1566443 1566444 MolTac:SD The SD Hannover was developed at the National Institutes of Health, Bethesda, USA. It later went to the Zentralinstitut fur Versuchstierzucht, Hannover, Germany (Han) and was received by M&B A/S in 1993. Taconic outbred Unknown RRID:RGD_1566444 1566445 ACI.BN-(D5Mgh17-D5Rat205)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 5 transferred to the ACI/SegHsd strain background Department of Genetics, Cell Biology and Anatomy, University Of Nebraska Medical Center, Omaha, Nebraska congenic Extinct 5 14730738 14730949 1 - by flanking markers 5 19190627 19190837 1 - by flanking markers 5 14408903 14409113 1 - by flanking markers 5 14529225 14529436 1 - by flanking markers RRID:RGD_1566445 1566447 GK/MolTac Goto-Kakizaki Originating at Tohoku University, Sendai, Japan in 1975, the Goto-Kakizaki rat was obtained by Aarhus University Hospital, Denmark in 1994. Received from Aarhus by M&B A/S in 1997. Taconic inbred Unknown RRID:RGD_1566447 1566448 FHH-Chr 9BN/Mcwi A FHH genomic background with a BN chromosome 9 introgressed. PhysGen consomic Cryopreserved Sperm RRID:RGD_1566448 1566453 SD-Tg(HIV-LacZ)AngRrrc Fertilized eggs were microinjected with 300-500 copies of DNA per egg which comprised of an insert (5,230 bp) containing U3R region, the lacZ gene and the SV 40 polyadenylation signal which was excised from the bacterial plasmid. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00049 1566454 BDIV/Zte BDIV/Zte derived from Berlin-Druckrey strain BDIV Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany inbred Unknown RRID:RGD_1566454 1566455 HTX/HcjRrrc Available at RRRC;these were originally bred by D. F. Kohn, Inst. of Comparative Medicine,Columbia University, New York. Then housed at University of Florida 1992 at F30. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery RRID:RRRC_00050 1566456 BDIX/Zte derived from Berlin-Druckrey strain BDIX Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany inbred Unknown RRID:RGD_1566456 1566457 SPRD Sprague-Dawley From outbred Han:SPRD (Sprague-Dawley) rats. Dominant pelage mutation designatedcurly-3 (Cu3) occured in 1975 at the Gesellschaft fur Strahlenforschung, Dortmund, Germany.Mutant animals returned to Hannover where inbreeding begun in 1976 (Greenhouse et al 1990). unknown inbred Unknown RRID:RGD_1566457 1566458 F344-Tg(ROSA26-ALPP)EpsRrrc F344 embryos were microinjected with R26-hPAP trangene which comprises of 0.8 kb genomic sequence of ROSA 26 promoter fused to human placental alkaline phosphatase (hPAP, ALPP). Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2019-07-01) ALPP 1314395 RRID:RRRC_00048 1566459 F344-Tg(ROSA26-EGFP)Eps F344 embryos were microinjected with R26-EGFP trangene which comprises of 0.8 kb genomic sequence of ROSA 26 promoter fused to enhanced green fluorescent protein (EGFP). Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin transgenic Unknown RRID:RGD_1566459 1566460 SD-Tg(ICAM2-DAF)AngRrrc Embryos were microinjected with DNA containing the human DAF(decay-acceletating factor) gene under control of the human ICAM2 promoter. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00051 1578692 BN.LEW-(D10Rat32-D10Rat116)/Ciml Congenic strain was bred from BN.LEW-(D10Mco17-D10Mco14)/Ciml backcrossed to BN/Rj. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 53786347 54220239 1 - by flanking markers 10 53381898 53807373 1 - by flanking markers 10 53630865 54057745 1 - by flanking markers 10 51779662 52200160 1 - by flanking markers RRID:RGD_1578692 1578693 LEW.BN-(D10Mco17-D10Rat221)/Ciml Congenic strain created from parental LEW/Rj and BN/Rj strains. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 45105978 45106380 1 - by flanking markers 10 44914976 44915377 1 - by flanking markers 10 45157430 45157831 1 - by flanking markers 10 43593509 43593911 1 - by flanking markers RRID:RGD_1578693 1578694 AT Alcohol-Tolerant The parents of the base stock were produced by crossbreeding female AA of the F22 generation of Wistar origin with Helsinki Zoo male albinos. AT rats are selectively bred at ALKO in Finland for ethanol-induced ataxia on the inclined plane. These were moved 1998 to University of Colorado. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00076 1578695 SHA/BruRrrc Syracuse High Avoidance Selective breeding of Long-Evans in active two-way shuttle box for high avoidance resulted in these SHA rats. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00068 1578696 LAS1 Low Alcohol Sensitive strain 1 Selectively bred for 24 generations for low sensitivity to ethanol then inbred. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00080 1578697 BN.LEW-(D10Rat32-D10Rat31)/Ciml Congenic strain was bred from BN.LEW-(D10Rat32-D10Rat221)/Ciml backcrossed to BN/Rj. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 53616237 53786515 1 - by flanking markers 10 53216481 53382065 1 - by flanking markers 10 53465198 53631032 1 - by flanking markers 10 51611529 51779830 1 - by flanking markers RRID:RGD_1578697 1578698 LAS2 Low Alcohol Sensitive strain 2 Selectively bred for 24 generations for low hypnotic response to high dose ethanol, then inbred Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00081 1578699 BG anemic Belgrade These are descendants of the original Belgrade colony which was obtained by K. Kellar Centers forDisease Control and Prevention, Atlanta, GA. These were backcrossed with Harlan Sprague-Dawley Wistar and then amintained as a closed colony in Buffalo, NY. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery RRID:RRRC_00072 1578700 HAS1 High Alcohol Sensitive strain 1 Selectively bred for high sensitivity for ethanol hypnosis for 24 generations then inbred Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00077 1578701 HAS2 High Alcohol Sensitive strain 2 Selectively bred for high ethanol sensitivity for 24 generations, then inbred. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00079 1578702 LEW.BN-(D10Rat32-D10Rat133)/Ciml Congenic strain created from parental LEW/Rj and BN/Rj strains. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 53786347 65668639 1 - by flanking markers 10 53381898 64823355 1 - by flanking markers 10 53630865 53631032 1 - by flanking markers 10 51779662 51779830 1 - by flanking markers RRID:RGD_1578702 1578703 SLA/BruRrrc Syracuse Low Avoidance Selective breeding of Long-Evans in active two-way shuttle box for low avoidance resulted in these SLA rats. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00069 1578704 WLP Warsaw Low Prefering These were bred from albino stock of Wistar rats as lines that had low ethanol preference. Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Sobieskiego 9, Warszawa, Poland inbred Unknown RRID:RGD_1578704 1578705 LEW.BN-(D10Arb4-D10Rat133)/Ciml Congenic strain created from parental LEW/Rj and BN/Rj strains. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 46737116 65668639 1 - by flanking markers 10 46591952 64823355 1 - by flanking markers 10 46835584 46835685 1 - by flanking markers 10 45274234 45274336 1 - by flanking markers RRID:RGD_1578705 1578706 LEW.BN-(D10Mco17-D10Mco14)/Ciml Congenic strain created from parental LEW/Rj and BN/Rj strains. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 45105978 45106380 1 - by flanking markers 10 44914976 44915377 1 - by flanking markers 10 45157430 45157831 1 - by flanking markers 10 43593509 43593911 1 - by flanking markers RRID:RGD_1578706 1578708 LEW.BN-(D10Mgh7-D10Rat221)/Ciml Congenic strain created from parental LEW/Rj and BN/Rj strains. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 56170962 56171177 1 - by flanking markers 10 55720558 55720772 1 - by flanking markers 10 55978483 55978697 1 - by flanking markers 10 54098674 54098889 1 - by flanking markers RRID:RGD_1578708 1578709 IA incisor absent These rats have incisors and molars formed embryogically but are unable to erupt as no openings in the alveolar bone was created by selective resoption. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00064 1578710 LEW.1AR1-iddm/Ztm arose through a spontaneous mutation in a congenic Lewis strain with a defined MHC haplotype (RT1.AaB/DuCu) in the intra-MHC recombinant inbred strain LEW.1AR1; mutation was discovered in Fx + 13 of the LEW.1AR1 and has been maintained as a separate strain since Institute for Laboratory Animal Science, Hannover Medical School, Hanover, Germany coisogenic Unknown Dock8m1Ztm 13830868 RRID:RGD_1578710 1578711 LEW.BN-(D10Mco17-D10Rat133)/Ciml Congenic strain created from parental LEW/Rj and BN/Rj strains. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 45105978 65668639 1 - by flanking markers 10 44914976 64823355 1 - by flanking markers 10 45157430 45157831 1 - by flanking markers 10 43593509 43593911 1 - by flanking markers RRID:RGD_1578711 1578712 BN.LEW-(D10Mco17-D10Mco14)/Ciml Congenic strain created from parental LEW/Rj and BN/Rj strains. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 45105978 45106380 1 - by flanking markers 10 44914976 44915377 1 - by flanking markers 10 45157430 45157831 1 - by flanking markers 10 43593509 43593911 1 - by flanking markers RRID:RGD_1578712 1578713 BN/Ztm substrain of BN Institute for Laboratory Animal Science, Hannover Medical School, Hanover, Germany inbred Unknown RRID:RGD_1578713 1578714 BN.LEW-(D10Mco17-D10Rat80)/Ciml Congenic strain created from parental LEW/Rj and BN/Rj strains. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 45105978 61798393 1 - by flanking markers 10 44914976 61030524 1 - by flanking markers 10 45157430 61300905 1 - by flanking markers 10 43593509 59378278 1 - by flanking markers RRID:RGD_1578714 1578715 ANT Alcohol-Nontolerant The parents of the base stock were produced by crossbreeding female AA of the F22 generation of Wistar origin with Helsinki Zoo male albinos. AT rats are selectively bred at ALKO in Finland for ethanol-induced ataxia on the inclined plane. These were moved 1998 to University of Colorado. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm Gabra6 61861 RRID:RRRC_00078 1578716 LEW.1AR1/Ztm Lewis strain containing MHC haplotype RT1.AaB/DuCu Institute for Laboratory Animal Science, Hannover Medical School, Hanover, Germany congenic Unknown RRID:RGD_1578716 1578717 WHP Warsaw High Prefering These were bred from albino stock of Wistar rats as lines that had ethanol preference. Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Sobieskiego 9, Warszawa, Poland inbred Unknown RRID:RGD_1578717 1579677 FHH-Maddm1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. G120R mutation is generated. PhysGen mutant Extinct (as of 2017-01-26) Maddm1Mcwi 1578796 3 75498321 75541073 1 - by flanking markers 3 86669054 86711776 1 - by flanking markers 3 79960301 80003023 1 - by flanking markers 3 77114330 77157865 1 - by flanking markers RRID:RGD_1579677 1579678 ACI.FHH-(D3Wox2-D3Rat59)/Eur Congenic strain originated from backcrossing ACI/Eur and FHH/Eur parental strains. Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Live Animals; Cryopreserved Sperm 3 46419462 163443738 1 - by flanking markers 3 57173123 176609927 1 - by flanking markers 3 50533100 170534769 1 - by flanking markers 3 49162911 161299569 1 - by flanking markers RRID:RGD_1579678 1579680 Wild/Tku Wild These rats were caught wild in Tokyo, Japan, used for experiments and then sacrificed. Caught in Tokyo wild Unknown RRID:RGD_1579680 1579681 BN-Birc3m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations.W76G mutation is generated. PhysGen mutant Extinct (as of 2016-10-24) Birc3m1Mcwi 1578788 8 4682202 4696856 1 - by flanking markers 8 6047454 6075236 1 - by flanking markers 8 6048590 6076828 1 - by flanking markers 8 5000844 5028470 1 - by flanking markers RRID:RGD_1579681 1579682 FHH-Tlr4m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. V489A mutation is generated. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Tlr4m1Mcwi 1578785 5 83564100 83577735 1 - by flanking markers 5 86690670 86704302 1 - by flanking markers 5 82587424 82601056 1 - by flanking markers 5 80145867 80159501 1 - by flanking markers RRID:RRRC_00411 1579683 FHH-Ghsrm1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. codon CAG/TAG mutation is generated which changes the AA Q343Stop. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Ghsrm1Mcwi 1578794 2 113269623 113272999 1 - by flanking markers 2 132784207 132789319 1 - by flanking markers 2 113065953 113071265 1 - by flanking markers 2 110268489 110271865 1 - by flanking markers RRID:RRRC_00405 1579684 FHH-Slc8a2m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. Y213Stop mutation is generated from the codon change TAT/TAA. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Slc8a2m1Mcwi 1578786 1 76473938 76498624 1 - by flanking markers 1 79296259 79320746 1 - by flanking markers 1 78029555 78054042 1 - by flanking markers 1 76816583 76852928 1 - by flanking markers RRID:RRRC_00404 1579685 FHH-Tgfbr2m2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. E311K mutation is generated from the codon change GAG/AAG. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Tgfbr2m2Mcwi 1578782 8 120593595 120680453 1 - by flanking markers 8 123585765 123671209 1 - by flanking markers 8 124310288 124399345 1 - by flanking markers 8 115794537 115883615 1 - by flanking markers RRID:RRRC_00400 1579686 GH/OmrMcwi This colony was established from rats of Wistar origin. This is an hysterectomy-derived colony at the University of Otago, which was established from the Wellcome Institute colony at generation 79. These have been inbred for over 90 generations. These were given to Dr. Howard Jacob in 1999 and have been bred in Medical College of Wisconsin since then. PhysGen inbred Live Animals; Cryopreserved Embryo RRID:RGD_1579686 1579687 FHH-Procm1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. L312P mutation is generated. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Procm1Mcwi 1578790 18 24563368 24573715 1 - by flanking markers 18 24633206 24643623 1 - by flanking markers 18 24918402 24928822 1 - by flanking markers 18 23764367 23774816 1 - by flanking markers RRID:RRRC_00410 1579688 BN-Tgfbr2m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. T289M mutation is generated from the codon change ACG/ATG. PhysGen mutant Extinct (as of 2017-01-26) Tgfbr2m1Mcwi 1578800 8 120593595 120680453 1 - by flanking markers 8 123585765 123671209 1 - by flanking markers 8 124310288 124399345 1 - by flanking markers 8 115794537 115883615 1 - by flanking markers RRID:RGD_1579688 1579689 FHH-F10m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. V453G mutation is generated from the codon change GTC/GGC. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) F10m1Mcwi 1578783 16 81327237 81346544 1 - by flanking markers 16 81288536 81307842 1 - by flanking markers 16 81803169 81822476 1 - by flanking markers 16 76468834 76488141 1 - by flanking markers RRID:RRRC_00401 1579690 FHH-Slc27a5m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. K196Stop is generated. PhysGen mutant Extinct (as of 2017-01-26) Slc27a5m1Mcwi 1578799 1 72924630 72935223 1 - by flanking markers 1 66387832 66398425 1 - by flanking markers 1 65576599 65587192 1 - by flanking markers 1 73616556 73627149 1 - by flanking markers RRID:RGD_1579690 1579691 SS.SHR-(D11Mgh3-D11Rat31)/Mco Congenic strain from the parental SS/Jr and SHR/NHsd inbred strains. Medical College of Ohio, Toledo, Ohio congenic Unknown 11 8176272 68234949 1 - by flanking markers 11 10373455 72739854 1 - by flanking markers 11 6673351 69649875 1 - by flanking markers 11 8200022 66422316 1 - by flanking markers RRID:RGD_1579691 1579692 FHH-Lcatm1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. H353L mutation is generated from the codon change CAC/CTC. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Lcatm1Mcwi 1578793 19 35781507 35784966 1 - by flanking markers 19 48780364 48783830 1 - by flanking markers 19 37913333 37916799 1 - by flanking markers 19 33834748 33838214 1 - by flanking markers RRID:RRRC_00402 1579693 T2DN/Mcwi Generated by crossing GK/Swe with female FHH/EurMcwi. During the F1 studies, the GK/Swe started to die out. In order to preserve the GK strain, single male GK was serially crossed to the ongoing GK-FHH cross. This resulted in rapid fixation of the original GK genome except for mitochondrial DNA. In the sixth generation male and female T2DN were intercrossed and strict b x s mating was maintained. Department of Physiology, Medical College of Wisconsin, Milwaukee Wisconsin inbred Unknown RRID:RGD_1579693 1579694 FHH-Egln3m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. E60G mutation is generated. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Egln3m1Mcwi 1578781 6 74451038 74476506 1 - by flanking markers 6 84592894 84618360 1 - by flanking markers 6 75050329 75075795 1 - by flanking markers 6 71650297 71675766 1 - by flanking markers RRID:RRRC_00409 1579695 ACI.FHH-(D1Rat298-D1Rat90)/Eur Congenic strain originated from backcrossing ACI/Eur and FHH/Eur parental strains. Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Unknown 1 225625031 267111153 1 - by flanking markers 1 247303036 289137268 1 - by flanking markers 1 240017117 281795785 1 - by flanking markers 1 219932573 259647894 1 - by flanking markers RRID:RGD_1579695 1579696 SS.SHR-(D6Wox13-D6Rat84)/Mco Congenic strain from the parental SS/Jr and SHR/NHsd inbred strains. Medical College of Ohio, Toledo, Ohio congenic Unknown 6 136451997 136452267 1 - by flanking markers 6 144273721 144273990 1 - by flanking markers 6 136142742 136143011 1 - by flanking markers 6 130729205 130729475 1 - by flanking markers RRID:RGD_1579696 1579697 SS.SHR-(D13Rat63-D13Mit1)/Mco Congenic strain from the parental SS/Jr and SHR/NHsd inbred strains. Medical College of Ohio, Toledo, Ohio congenic Unknown 13 25430110 80482429 1 - by flanking markers 13 14281836 87877411 1 - by flanking markers 13 9016742 82995671 1 - by flanking markers 13 5994668 77046890 1 - by flanking markers RRID:RGD_1579697 1579698 FHH-Adra1am1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. G393V mutation is generated on rat Adra1a. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Adra1am1Mcwi 1578792 15 46173429 46263198 1 - by flanking markers 15 48197628 48297316 1 - by flanking markers 15 43296997 43398314 1 - by flanking markers 15 40830125 40935902 1 - by flanking markers RRID:RRRC_00408 1579699 WKY.WKHA-(D5Rat45-D5Rat245)/Cfd WKY.WKHA-(D5Rat45-D5Rat245)/Cfd This congenic strain contains a region of WKHA/Cfd chromosome 5 transferred to the WKY/Cfd strain background Experimental Cardiovascular Biology Laboratory, Institut de Recherches Cliniques de Montreal, 119 Pine Ave W, Montreal, Quebec CA congenic Unknown 5 159265355 159265706 1 - by flanking markers 5 162571275 162571427 1 - by flanking markers 5 158854038 158854190 1 - by flanking markers 5 152630083 152630236 1 - by flanking markers RRID:RGD_1579699 1579700 ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur Double congenic strain from backcross of ACI.FHH-(D1Rat298-D1Rat90)/Eur and ACI.FHH-(D3Wox2-D3Rat59)/Eur. Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Unknown RRID:RGD_1579700 1579701 BN-Nos1m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. L72Stop mutation is generated. PhysGen mutant Extinct (as of 2017-01-26) Nos1m1Mcwi 1578795 12 39812500 39869484 1 - by flanking markers 12 46049288 46209569 1 - by flanking markers 12 44214949 44405530 1 - by flanking markers 12 38615111 38795492 1 - by flanking markers RRID:RGD_1579701 1579702 SS.SHR-(D9Wox16-D9Rat64)/Mco Congenic strain from the parental SS/Jr and SHR/NHsd inbred strains. Medical College of Ohio, Toledo, Ohio congenic Unknown 9 21667066 21667256 1 - by flanking markers 9 27914255 97338238 1 - by flanking markers 9 29075079 97647719 1 - by flanking markers 9 25268044 91090963 1 - by flanking markers RRID:RGD_1579702 1579703 SS.SHR-(D2Rat61-D2Mco18)/Mco Congenic strain from the parental SS/Jr and SHR/NHsd inbred strains. Medical College of Ohio, Toledo, Ohio congenic Unknown 2 79796833 227150249 1 - by flanking markers 2 88594475 100298539 1 - by flanking markers 2 68865414 80632096 1 - by flanking markers 18;2 79924734;78665619 79925127;78665763 1 - by flanking markers;1 - by flanking markers RRID:RGD_1579703 1579704 FHH-Agtr1bm1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. A 3bp deletion generates a mutation at TTC (del251F)of rat Agtr1b. PhysGen, Rat Resource & Research Center mutant Extinct (as of 2016-11-29) Agtr1bm1Mcwi 1578784 2 105503269 105602591 1 - by flanking markers 2 124879262 124954378 1 - by flanking markers 2 105149020 105224335 1 - by flanking markers 2 102844969 102920232 1 - by flanking markers RRID:RGD_1579704 1579705 FHH-Nr0b2m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. G96R mutation is generated from the codon change GGC/CGC. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Nr0b2m1Mcwi 1578798 5 151524685 151528000 1 - by flanking markers 5 155465275 155468590 1 - by flanking markers 5 151776004 151779319 1 - by flanking markers 5 145779294 145782609 1 - by flanking markers RRID:RRRC_00403 1579706 FHH-Nr4a1m1Mcwi Male founders (FHH/EurMcwi) were injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups were genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. Y130Stop mutation was generated from the codon change TAC/TAA. PhysGen mutant Cryopreserved Sperm (as of 2017-01-26) Nr4a1m1Mcwi 1578791 7 140012807 140020590 1 - by flanking markers 7 140700242 140721073 1 - by flanking markers 7 142899358 142920216 1 - by flanking markers 7 132368399 132389300 1 - by flanking markers RRID:RGD_1579706 1579707 FHH-Adipoqm2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. I164N mutation is generated in rat Adipoq. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-13) Adipoqm2Mcwi 1578797 11 79908291 79911065 1 - by flanking markers 11 84363940 84382663 1 - by flanking markers 11 81330845 81344488 1 - by flanking markers 11 77721912 77735644 1 - by flanking markers RRID:RRRC_00407 1579708 FHH-Desm1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. S25T mutation is generated. PhysGen mutant Extinct (as of 2017-01-26) Desm1Mcwi 1578801 9 74637783 74645499 1 - by flanking markers 9 82325835 82333549 1 - by flanking markers 9 82556574 82564288 1 - by flanking markers 9 76850979 76858695 1 - by flanking markers RRID:RGD_1579708 1579709 Wild/Mcwi Wild These rats were caught wild in Milwaukee, used for experiments and then sacrificed. Caught in Milwaukee wild Unknown RRID:RGD_1579709 1579710 GK/Far Goto-Kakizaki Generated by selective brother x sister breeding of 18 non-diabetic Jcl:Wistar rats which were glucose intolerant on oral glucose tolerant tests. This colony is from F36 generation of the Japanese colony provided by Drs. Suzuki and Toyota of Tokoku University , Sendai Japan. James A. Haley Veterans Hospital, Tampa Florida inbred Unknown RRID:RGD_1579710 1579711 FHH-Adipoqm1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations.Y162C mutation is generated on rat Adipoq. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-13) Adipoqm1Mcwi 1578787 11 79908291 79911065 1 - by flanking markers 11 84363940 84382663 1 - by flanking markers 11 81330845 81344488 1 - by flanking markers 11 77721912 77735644 1 - by flanking markers RRID:RRRC_00406 1579712 FHH-Klf6m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. V135G mutation is generated. PhysGen mutant Extinct (as of 2017-01-26) Klf6m1Mcwi 1578789 17 75578498 75585072 1 - by flanking markers 17 69616967 69674031 1 - by flanking markers 17 67887939 67945052 1 - by flanking markers 17 64539456 64548451 1 - by flanking markers RRID:RGD_1579712 1579894 SS.LEW-(D10Rat204-D10Rat9)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Rat119-D10Mgh1)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 94837236 99588446 1 - by flanking markers 10 93421499 93421719 1 - by flanking markers 10 93662786 93663006 1 - by flanking markers 10 90404397 90404618 1 - by flanking markers RRID:RGD_1579894 1579895 FHH-Bdkrb2m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. I214T mutation is generated. PhysGen mutant Extinct (as of 2016-10-24) Bdkrb2m1Mcwi 1579889 6 129744781 129748851 1 - by flanking markers 6 138615812 138622272 1 - by flanking markers 6 129399468 129429676 1 - by flanking markers 6 124472317 124502497 1 - by flanking markers RRID:RGD_1579895 1579896 SS.LEW-(D2Rat18-D2Chm277)/Ayd Congenic strain was created from a SS/Jr parental strain Research Centre Hospitalier de l'Universite de Montreal, Quebec, Canada congenic Unknown 2 40912197 56722286 1 - by flanking markers 2 60126669 76472773 1 - by flanking markers 2 41063439 56736627 1 - by flanking markers 2 41125789 56532139 1 - by flanking markers RRID:RGD_1579896 1579897 SS.SR-(D9Rat69-D9Mco14)/Mco A congenic strain derived from the progenitor strains SS and SR. Department of Physiology and Cardiovascular Genomics, Medical College of Ohio, Toledo, Ohio congenic Unknown 9 66679876 74437140 1 - by flanking markers 9 74640722 82125547 1 - by flanking markers 9 74858383 82356286 1 - by flanking markers 9 69371595 76650886 1 - by flanking markers RRID:RGD_1579897 1579898 SS.LEW-(D10Chm128-D10Chm121)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Wox51-D10Rat27)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 70486334 71365656 1 - by flanking markers 10 69272915 71014829 1 - by flanking markers 10 69638898 70499629 1 - by flanking markers 10 67232398 68082614 1 - by flanking markers RRID:RGD_1579898 1579899 SS.LEW-(D5Rat130-D5Rat31)/JrMcwi SS.LEW-(D5Rat130-D5Rat31)/JrMcwi This congenic strain contains a LEW chromosome 5 segment transferred to the Dahl salt sensitive background. The strain was originally developed by Drs. Rapp and M. R. Garrett at the Medical University of Ohio and has also been maintained by brother-sister mating at the Medical College of Wisconsin for more than 20 generations. Department of Physiology, Medical College of Wisconsin, Milwaukee congenic Unknown 5 32701659 139996194 1 - by flanking markers 5 36590997 142265366 1 - by flanking markers 5 31926122 138454239 1 - by flanking markers 5 31663789 133011550 1 - by flanking markers RRID:RGD_1579899 1579900 SS.SR-(D9Rat89-Resp18)/Mco Congenic strain was created by backcrossing SR strain into the parental Dahl Salt-sensitive (SS) strain Medical College of Ohio, Toledo, Ohio congenic Unknown Resp18 3555 9 72257996 74558151 1 - by flanking markers 9 80172493 82246695 1 - by flanking markers 9 80400409 82477136 1 - by flanking markers 9 74701668 76771824 1 - by flanking markers RRID:RGD_1579900 1579901 SS.LEW-(D10Chm224-D10Chm6)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Wox51-D10Rat27)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 74705355 76000447 1 - by flanking markers 10 75100237 76438561 1 - by flanking markers 10 75001953 76556637 1 - by flanking markers 10 72508825 72509024 1 - by flanking markers RRID:RGD_1579901 1579902 SS.LEW-(D5Rat130-D5Rat108)/JrMcwi SS.LEW-(D5Rat130-D5Rat108)/JrMcwi This congenic strain contains a LEW chromosome 5 segment transferred to the Dahl salt sensitive background. The strain was originally developed by Drs. Rapp and M. R. Garrett at the Medical University of Ohio and has also been maintained by brother-sister mating at the Medical College of Wisconsin for more than 20 generations. Department of Physiology, Medical College of Wisconsin, Milwaukee congenic Unknown 5 32701659 134872385 1 - by flanking markers 5 36590997 137108002 1 - by flanking markers 5 31926122 133313852 1 - by flanking markers 5 31663789 128034027 1 - by flanking markers RRID:RGD_1579902 1579903 SS.LEW-(D10Chm10-D10Rat11)/Ayd A congenic substrain derived from the progenitor strain SS.LEW-(D10Rat119-D10Mgh1)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 97152234 100633982 1 - by flanking markers 10 95701164 99184250 1 - by flanking markers 10 95967019 99492409 1 - by flanking markers 10 92698959 96121100 1 - by flanking markers RRID:RGD_1579903 1579904 SS.SR-(D9Mgh11-D9Mco33)/Mco A congenic strain derived from the progenitor strains SS and SR. Department of Physiology and Cardiovascular Genomics, Medical College of Ohio, Toledo, Ohio congenic Unknown 10 86983905 86984155 1 - by flanking markers 10 85965754 85966003 1 - by flanking markers 10 86168841 86169090 1 - by flanking markers 10 83212828 83213078 1 - by flanking markers RRID:RGD_1579904 1579905 SS.SR-(D9Rat89-D9Mco27)/Mco Congenic strain derived from parental strains SS and SR. Department of Physiology and Cardiovascular Genomics, Medical College of Ohio, Toledo, Ohio congenic Unknown 9;10 72257996;76477677 72258219;76477875 1 - by flanking markers;1 - by flanking markers 9;10 80172493;74600366 80172715;74600564 1 - by flanking markers;1 - by flanking markers 9;10 80400409;75505821 80400631;75506019 1 - by flanking markers;1 - by flanking markers 9;10 74701668;72976092 74701891;72976291 1 - by flanking markers;1 - by flanking markers RRID:RGD_1579905 1579906 FHH-Adipoqm3Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. L119P mutation is generated from the codon change CTG/CCG of rat Adipoq. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-13) Adipoqm3Mcwi 1579887 11 79908291 79911065 1 - by flanking markers 11 84363940 84382663 1 - by flanking markers 11 81330845 81344488 1 - by flanking markers 11 77721912 77735644 1 - by flanking markers RRID:RRRC_00414 1579907 SS.LEW-(D10Chm128-D10Chm169)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Wox51-D10Rat27)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 70486334 70654393 1 - by flanking markers 10 69272915 69442411 1 - by flanking markers 10 69638898 69809020 1 - by flanking markers 10 67232398 67400546 1 - by flanking markers RRID:RGD_1579907 1579908 SS.SR-(D9Mco95-Resp18)/Mco A congenic strain derived from the progenitor strains SS and SR. Department of Physiology and Cardiovascular Genomics, Medical College of Ohio, Toledo, Ohio congenic Unknown Resp18 3555 9 74551809 74558151 1 - by flanking markers 9 80867159 82246695 1 - by flanking markers 9 81100315 82477136 1 - by flanking markers 9 75403227 76771824 1 - by flanking markers RRID:RGD_1579908 1579909 FHH-Fgl2m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. A301S mutation is generated from the codon change GCA/TCA. PhysGen mutant Extinct (as of 2017-01-26) Fgl2m1Mcwi 1579885 4 9176333 9181976 1 - by flanking markers 4 10315666 10321309 1 - by flanking markers 4 10323598 10329241 1 - by flanking markers 4 13710566 13716207 1 - by flanking markers RRID:RGD_1579909 1579910 FHH-Ccr2m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. N117S mutation is generated from the codon change AAT/AGT. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Ccr2m1Mcwi 1579888 8 128892784 128893905 1 - by flanking markers 8 123734465 123742483 1 - by flanking markers RRID:RRRC_00399 1579911 SS.LEW-(D5Rat130-D5Rat72)/Mcwi SS.LEW-(D5Rat130-D5Rat72)/Mcwi This congenic strain contains a LEW chromosome 5 segment transferred to the Dahl salt sensitive background. Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee congenic Unknown 5 32701659 120983466 1 - by flanking markers 5 36590997 123028200 1 - by flanking markers 5 31926122 119125145 1 - by flanking markers 5 31663789 114973531 1 - by flanking markers RRID:RGD_1579911 1579912 FHH-F10m2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. C388 Stop mutation is generated from the codon change TGC/TGA PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) F10m2Mcwi 1579886 16 81327237 81346544 1 - by flanking markers 16 81288536 81307842 1 - by flanking markers 16 81803169 81822476 1 - by flanking markers 16 76468834 76488141 1 - by flanking markers RRID:RRRC_00412 1579913 SS.LEW-(D10Chm224-D10Chm222)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Wox51-D10Rat27)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 74705355 76477875 1 - by flanking markers 10 74600366 76309841 1 - by flanking markers 10 75505821 75506019 1 - by flanking markers 10 72976092 72976291 1 - by flanking markers RRID:RGD_1579913 1579914 SS.LEW-(D10Mco30-D10Got92)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Rat27-Igfbp4)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 77547289 77956387 1 - by flanking markers 10 73693979 76919627 1 - by flanking markers 10 76420583 77055888 1 - by flanking markers 10 73887148 74372232 1 - by flanking markers RRID:RGD_1579914 1580542 PCK-Pkhd1pck/CrljCrl This model of polycystic kidney disease showing both kidney and liver involvement was identified in a colony of CD rats from the Charles River Japan production facility. The identification of the Pkhd1 gene mutation was reported by Harris and associates in 2002. This autosomal recessive Pkhd1 gene mutation is a model of human autosomal-recessive polycystic kidney disease (ARPKD). Charles River Laboratories coisogenic Unknown Pkhd1pck 11535943 RRID:RGD_1580542 1581616 DA.ACI-(D15Rat23-D15Rat71)/Kini DA.ACI-(D15Rat23-D15Rat71)/Kini This congenic strain contains an ACI chromosome 15 segment transferred to the DA background strain Center for Molecular Medicine, Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, SE-17176 Stockholm, Sweden congenic Unknown 15 83040937 85456512 1 - by flanking markers 15 87155990 89768452 1 - by flanking markers 15 83647062 86002030 1 - by flanking markers 15 76003569 78330139 1 - by flanking markers RRID:RGD_1581616 1581617 SD-Tg(Ubc-eGFP-RNAi:Dazl)16-13Gar This transgenic strain was made by injecting the lentivirus vector into SD rat embryos. Founders were identified by PCR and then bred with wild-type SD rats. The vectors are derived from pLL3.7 and contains GFP and short hairpain RNA (shRNA) University of Texas Southwestern Medical Center, Dallas Texas transgenic Unknown RRID:RGD_1581617 1581618 SHRSP/Bbb This SHRSP colony as obtained from the original Japanese stock from Okamoto and Aoki in 1974 and is propagated by strict inbreeding. Now this colony is maintained at University of Heidelberg, Heidelburg, Germany. Max - Delbruck - Center for Molecular Medicine, Germany inbred Unknown RRID:RGD_1581618 1581619 BN.PD-(D8Rat39-D8Rat35),SHR-(D2Mit4-D2Rat28),SHR-(D2Rat103-D2Rat107)/Cub This triple congenic strain has two segments of chr 2 spanning 53 Mb(centromeric segment) and 92 Mb (telomeric segment) from SHR and a differential segment of chr 8 of PD/Cub introgressed into BN-Lx. Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic congenic Unknown RRID:RGD_1581619 1581620 SS.SR-(D9Mco61-D9Mco27)/Mco A congenic strain derived from the progenitor strains SS and SR. Department of Physiology and Cardiovascular Genomics, Medical College of Ohio, Toledo, Ohio congenic Unknown RRID:RGD_1581620 1581621 DA.ACI-(D15Rat6-D15Rat48)/Kini DA.ACI-(D15Rat6-D15Rat48)/Kini This congenic strain contains an ACI chromosome 15 segment transferred to the DA background strain Center for Molecular Medicine, Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, SE-17176 Stockholm, Sweden congenic Unknown 15 32638412 61161186 1 - by flanking markers 15 37103190 65959514 1 - by flanking markers 15 33219101 62301382 1 - by flanking markers 15 28030665 55302115 1 - by flanking markers RRID:RGD_1581621 1581622 SD-Tg(Ubc-eGFP-RNAi:Dazl)17-9GarRrrc This transgenic strain was made by injecting the lentivirus vector into SD rat embryos. Founders were identified by PCR and then bred with wild-type SD rats. The vectors are derived from pLL3.7 and contains GFP and short hairpain RNA (shRNA) University of Texas Southwestern Medical Center, Dallas, Texas; Rat Resource and Research Center transgenic Cryopreserved Embryo (as of 2017-08-17) RRID:RRRC_00318 1581623 LA/Humd low autotomy Low Autotomy segregation line derived from Sabra (Wistar derived) outbred stock. Males and females of low autotomy scores were coupled randomly. After each generation pairs were randomly selected from the available offspring from different litters. Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel segregating_inbred Unknown RRID:RGD_1581623 1581624 FHH-Lipem1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. L347P mutation is generated from the codon change CTA/CCA. PhysGen mutant Extinct (as of 2017-01-26) Lipem1Mcwi 1581495 1 80663791 80682480 1 - by flanking markers 1 83511504 83530200 1 - by flanking markers 1 82248031 82266727 1 - by flanking markers 1 80965612 80984313 1 - by flanking markers RRID:RGD_1581624 1581625 BN-Hand1m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. S109G mutation is generated from the codon change AGC/GGC. PGA mutant Unknown Hand1m1Mcwi 1581493 10 43423366 43425933 1 - by flanking markers 10 43050068 43052635 1 - by flanking markers 10 43250729 43253296 1 - by flanking markers 10 42006646 42009213 1 - by flanking markers RRID:RGD_1581625 1581626 FHL/EurMcwi Fawn Hooded Low blood pressure The low blood pressure colony was transferred from Erasmus University to Medical College of Wisconsin, Milwaukee, USA. FHL rats do not develop hypertension or renal damage. PGA inbred Unknown RRID:RGD_1581626 1581627 WF.WKY-(D5Uwm66-D5Uwm67)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Wox7-D5Uwm37). University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 73080117 79919776 1 - by flanking markers 5 76105513 82897734 1 - by flanking markers 5 71940894 78777811 1 - by flanking markers 5 69927283 76370048 1 - by flanking markers RRID:RGD_1581627 1581628 DA.ACI-(D15Rat6-D15Rat13)/Kini DA.ACI-(D15Rat 6-D15Rat13)/Kini This congenic strain contains an ACI chromosome 15 segment transferred to the DA background strain Center for Molecular Medicine, Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, SE-17176 Stockholm, Sweden congenic Unknown 15 32638412 43772355 1 - by flanking markers 15 37103190 51565184 1 - by flanking markers 15 33219101 47814460 1 - by flanking markers 15 28030665 38692741 1 - by flanking markers RRID:RGD_1581628 1581629 WF.WKY-(D5Wox8-D5Uwm62)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Wox7-D5Uwm37). University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 4291144 61238981 1 - by flanking markers 5 4498411 64739489 1 - by flanking markers 5 4525738 60225339 1 - by flanking markers 5 5112159 58973694 1 - by flanking markers RRID:RGD_1581629 1581630 WF.WKY-(D5Uwm63-D5Uwm64)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Wox7-D5Uwm37). University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 57848236 62299211 1 - by flanking markers 5 61271852 65886550 1 - by flanking markers 5 56733010 61370302 1 - by flanking markers 5 55564549 60051321 1 - by flanking markers RRID:RGD_1581630 1581631 WF.WKY-(D5Uwm61-D5Uwm37)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Wox7-D5Uwm37). University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 84434303 130527490 1 - by flanking markers 5 87362775 132652105 1 - by flanking markers 5 83268986 128812854 1 - by flanking markers 5 80813116 123935338 1 - by flanking markers RRID:RGD_1581631 1581632 WF.WKY-(D5Uwm65-D5Uwm60)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Wox7-D5Uwm37). University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 65553185 76159022 1 - by flanking markers 5 72838045 79426001 1 - by flanking markers 5 68395096 75274687 1 - by flanking markers 5 63190890 72943679 1 - by flanking markers RRID:RGD_1581632 1581633 DA.ACI-(D15Rat6-D15Rat71)/Kini DA.ACI-(D15Rat6-D15Rat71)/Kini This congenic strain contains an ACI chromosome 15 segment transferred to the DA background strain Center for Molecular Medicine, Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, SE-17176 Stockholm, Sweden congenic Unknown 15 32638412 85456512 1 - by flanking markers 15 37103190 89768452 1 - by flanking markers 15 33219101 86002030 1 - by flanking markers 15 28030665 78330139 1 - by flanking markers RRID:RGD_1581633 1581634 BN-Adora2am1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. C249S mutation is generated from the codon change TGT/AGT of rat Adora2a. PhysGen mutant Extinct (as of 2016-10-24) Adora2am1Mcwi 1581476 20 13815719 13834131 1 - by flanking markers 20 16449385 16466147 1 - by flanking markers 20 14265251 14282873 1 - by flanking markers 20 13315848 13333386 1 - by flanking markers RRID:RGD_1581634 1581635 WKY/Bbb This WKY colony was obtained from the Japanese colony in 1974. Now this is maintained at University of Heidelberg, Heidelburg, Germany. Max - Delbruck - Center for Molecular Medicine, Germany inbred Unknown RRID:RGD_1581635 1581636 BN-Cebpem1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. E37G mutation is generated from the codon change GAG/GGG. PGA mutant Unknown Cebpem1Mcwi 1581494 15 32787946 32789344 1 - by flanking markers 15 37241081 37242479 1 - by flanking markers 15 33356119 33357517 1 - by flanking markers 15 28169885 28171283 1 - by flanking markers RRID:RGD_1581636 1581637 FHH-Has1m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. F55L mutation is generated from the codon change TTT/TTG. PhysGen mutant Extinct (as of 2017-01-26) Has1m1Mcwi 1581477 1 56503365 56516133 1 - by flanking markers 1 60640270 60652067 1 - by flanking markers 1 59720612 59732409 1 - by flanking markers 1 58693411 58705653 1 - by flanking markers RRID:RGD_1581637 1581638 DA.ACI-(D15Rat126-D15Rat71)/Kini DA.ACI-(D15Rat126-D15Rat71)/Kini This congenic strain contains an ACI chromosome 15 segment transferred to the DA background strain Center for Molecular Medicine, Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, SE-17176 Stockholm, Sweden congenic Unknown 15 85456315 85456512 1 - by flanking markers 15 86610850 89768452 1 - by flanking markers 15 83094829 86002030 1 - by flanking markers 15 75448637 78330139 1 - by flanking markers RRID:RGD_1581638 1581639 HAn/Humd high autotomy new Males and females of high autotomy scores from HA/Humd were coupled randomly. After each generation pairs were randomly selected from the available offspring from different litters. Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel segregating_inbred Unknown RRID:RGD_1581639 1581640 HA/Humd high autotomy High Autotomy segregation line derived from Sabra (Wistar derived) outbred stock. Males and females of high autotomy scores were coupled randomly. After each generation pairs were randomly selected from the available offspring from different litters. Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel segregating_inbred Unknown RRID:RGD_1581640 1581641 WF.WKY-(D5Uwm68-D5Mit4)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Wox7-D5Uwm37). University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 77277626 94516069 1 - by flanking markers 5 80544432 97315322 1 - by flanking markers 5 76401130 93273395 1 - by flanking markers 5 74047272 90450412 1 - by flanking markers RRID:RGD_1581641 1581642 FHH-Ccr4m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. I133V mutation is generated from the codon change ATA/GTA. PhysGen mutant Extinct (as of 2017-01-26) Ccr4m1Mcwi 1581492 8 118883148 118884230 1 - by flanking markers 8 121843005 121848545 1 - by flanking markers 8 122530152 122535959 1 - by flanking markers 8 114176256 114182155 1 - by flanking markers RRID:RGD_1581642 1581643 LAn/Humd low autotomy new Males and females of low autotomy scores from LA/Humd were coupled randomly. After each generation pairs were randomly selected from the available offspring from different litters. Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel segregating_inbred Unknown RRID:RGD_1581643 1581644 FHH-Htr1am1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. C266Y mutation is generated from the codon change TGT/TAT. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Htr1am1Mcwi 1581496 2 36434518 36435786 1 - by flanking markers 2 55362662 55363930 1 - by flanking markers 2 36246628 36247896 1 - by flanking markers 2 36694174 36695442 1 - by flanking markers RRID:RRRC_00413 1581645 LL/Mav In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed unrestrained conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. Laboratoire de Physiologie, 8 Avenue Rockfeller, 69373 Lyon Cedex 08, France inbred Unknown RRID:RGD_1581645 1582184 SR/JrHsd Dahl Salt-Resistant Substrain of Dahl SR, from a Sprague-Dawley outbred colony, selected for resistance to salt-induced hypertension (Dahl, 1962), from Dr. John P. Rapp, Medical College of Ohio, Toledo,Ohio; to Harlan in 1986. Envigo inbred Unknown RRID:RGD_1582184 1582185 SS.SR-(D3Mco36-D3Got166)/Jr SS.SR-(D3Mco19-D3Mco5)/Jr rats were crossed with SS to yield F1, these heterozygous rats were intercrossed to obtain F2 which were screened to identify the SR-rat derived region, these were then crossed with SS to duplicate the recombinant chromosome Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 3 166484910 171009778 1 - by flanking markers 3 178896560 181074971 1 - by flanking markers 3 172850273 177366660 1 - by flanking markers 3 163556062 168974694 1 - by flanking markers RRID:RGD_1582185 1582186 FHH.FHH.1BN-(D1Rat183-D1Rat76)/Mcwi FHH-1BN/Mcwi was backcrossed with FHH/EurMcwi to generate these rats. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 1 131123181 230411453 1 - by flanking markers 1 138077032 252243871 1 - by flanking markers 1 137083889 244992610 1 - by flanking markers 1 129384185 224569684 1 - by flanking markers RRID:RGD_1582186 1582187 SS.SR-(D3Mco24-D3Got130)/Jr SS.SR-(D3Mco19-D3Mco5)/Jr rats were crossed with SS to yield F1, these heterozygous rats were intercrossed to obtain F2 which were screened to identify the SR-rat derived region, these were then crossed with SS to duplicate the recombinant chromosome Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 3 149822571 166525892 1 - by flanking markers 3 160026579 178936339 1 - by flanking markers 3 155586270 172890235 1 - by flanking markers 3 147739514 163596045 1 - by flanking markers RRID:RGD_1582187 1582188 SS.SR-(D3Mco36-D3Mco46)/Jr SS.SR-(D3Mco19-D3Mco5)/Jr rats were crossed with SS to yield F1, these heterozygous rats were intercrossed to obtain F2 which were screened to identify the SR-rat derived region, these were then crossed with SS to duplicate the recombinant chromosome Medical College of Ohio, Toledo, Ohio, USA, Rat Resource and Research Center, congenic Cryopreserved Sperm (as of 2019-02-18) 3 168983202 171009778 1 - by flanking markers 3 181074759 181830490 1 - by flanking markers 3 175283587 177366660 1 - by flanking markers 3 167003822 168974694 1 - by flanking markers RRID:RRRC_00660 1582189 SS.SR-(D3Mco39-D3Got130)/Jr SS.SR-(D3Mco19-D3Mco5)/Jr rats were crossed with SS to yield F1, these heterozygous rats were intercrossed to obtain F2 which were screened to identify the SR-rat derived region, these were then crossed with SS to duplicate the recombinant chromosome Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 3 149822571 149823173 1 - by flanking markers 3 160026579 180014700 1 - by flanking markers 3 155586270 176305870 1 - by flanking markers 3 147739514 167914627 1 - by flanking markers RRID:RGD_1582189 1582190 SS/JrHsd Dahl Salt-Sensitive Substrain of Dahl SS, from a Sprague-Dawley outbred colony, selected for sensitivity to salt-induced hypertension (Dahl, 1962), from Dr. John P. Rapp, Medical College of Ohio, Toledo,Ohio; to Harlan in 1986. Envigo inbred Unknown RRID:RGD_1582190 1582191 FHH.FHH.1BN-(D1Rat287-D1Rat84)/Mcwi FHH-1BN/Mcwi was backcrossed with FHH/EurMcwi to generate these rats. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 1 190114247 259322833 1 - by flanking markers 1 208389496 281400240 1 - by flanking markers 1 201358068 273987019 1 - by flanking markers 1 185356336 252280168 1 - by flanking markers RRID:RGD_1582191 1582192 SS.SR-(D3Mco36-D3Got159)/Jr SS.SR-(D3Mco19-D3Mco5)/Jr rats were crossed with SS to yield F1, these heterozygous rats were intercrossed to obtain F2 which were screened to identify the SR-rat derived region, these were then crossed with SS to duplicate the recombinant chromosome Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 3 162807724 171009778 1 - by flanking markers 3 181074759 181074971 1 - by flanking markers 3 177366448 177366660 1 - by flanking markers 3 168974481 168974694 1 - by flanking markers RRID:RGD_1582192 1582193 FHH.FHH.1BN-(D1Mgh13-D1Rat89)/Mcwi FHH-1BN/Mcwi was backcrossed with FHH/EurMcwi to generate these rats. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 1 252340389 265343617 1 - by flanking markers 1 274224224 287349830 1 - by flanking markers 1 266793821 279986079 1 - by flanking markers 1 245907761 257976495 1 - by flanking markers RRID:RGD_1582193 1582194 SS.SR-(D3Mco78-D3Got130)/Jr SS.SR-(D3Mco19-D3Mco5)/Jr rats were crossed with SS to yield F1, these heterozygous rats were intercrossed to obtain F2 which were screened to identify the SR-rat derived region, these were then crossed with SS to duplicate the recombinant chromosome Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 3 149822571 164079729 1 - by flanking markers 3 160026579 177341735 1 - by flanking markers 3 155586270 171277347 1 - by flanking markers 3 147739514 161994638 1 - by flanking markers RRID:RGD_1582194 1582195 FHH.FHH.1BN-(D1Rat173F6B-D1Rat84)/Mcwi FHH-1BN/Mcwi was backcrossed with FHH/EurMcwi to generate these rats. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 1 259322503 259322833 1 - by flanking markers 1 281400069 281400240 1 - by flanking markers 1 273986848 273987019 1 - by flanking markers 1 252279996 252280168 1 - by flanking markers RRID:RGD_1582195 1582196 FHH.FHH.1BN-(D1Rat234-D1Rat265)/Mcwi FHH-1BN/Mcwi was backcrossed with FHH/EurMcwi to generate these rats. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 1 41225047 90449243 1 - by flanking markers 1 95453405 95453561 1 - by flanking markers 1 94364073 94364229 1 - by flanking markers 1 90664883 90665040 1 - by flanking markers RRID:RGD_1582196 1598797 WF.WKY-(D10Got124-D10Rat187)/Uwm WKY/NHsd females were bred with WF/NHsd males to generate F1 males which were backcrossed with WF/NHsd females. This contains 24.7 Mb region of Mcs7 QTL. Department of Oncology, University of Wisconsin, Madison Wisconsin congenic Unknown 10 89575059 110385665 1 - by flanking markers 10 88338460 109941891 1 - by flanking markers 10 88544136 110355174 1 - by flanking markers 10 85565469 106428971 1 - by flanking markers RRID:RGD_1598797 1598798 BBDP/WorN Diabetes prone BB rats maintained in NIH. Developed from a closed colony of outbred wistar rats which spontaneously developed autoimmune diabetes mellitus at the Bio-Breeding Laboratories, Ontario. University of Massachusetts Medical Center started inbreeding these in 1977. In 1983 NIH established a reference colony from this inbred colony. NIH Autoimmune Rat Model Repository and Dev Ctr inbred Extinct (as of 2021-02-22) RRID:RRRC_00092 1598799 ACI.FHH-(D1Rat384-D1Rat452)(D17Rat61-D1Arb5)(D17Rat51)/Eur Triple congenic strain which was generated using the speed congenic strategy by backcrossing ACI/Eur and FHH/Eur parental strains. Rf1 QTL region of chr 1 and Rf5 QTL region of chr 17 are introgressed in this strain. Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Unknown RRID:RGD_1598799 1598800 ACI.FHH-(D1Rat384-D1Rat156)/Eur Congenic strain which was generated using the speed congenic strategy by backcrossing ACI/Eur and FHH/Eur parental strains. Rf1 QTL region of chr 1 is introgressed in this strain. Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Unknown 1 229184432 253410500 1 - by flanking markers 1 250993318 279213254 1 - by flanking markers 1 243737319 243737466 1 - by flanking markers 1 223390805 223390953 1 - by flanking markers RRID:RGD_1598800 1598801 ACI.FHH-(D1Mit18-D1Mit8)(D14Mit11-D14Hmgc14b)(D14Rat65-D14Rat90)/Eur Triple congenic strain which was generated using the speed congenic strategy by backcrossing ACI/Eur and FHH/Eur parental strains. Rf1 QTL region of chr 1 and Rf4 QTL region of chr 14 are introgressed in this strain. Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Unknown RRID:RGD_1598801 1598802 BBDR/WorN Diabetes resistant BB rats maintained in NIH. Developed from a closed colony of outbred wistar rats which spontaneously developed autoimmune diabetes mellitus at the Bio-Breeding Laboratories, Ontario. University of Massachusetts Medical Center started inbreeding these in 1977. In 1983 NIH established a reference colony from this inbred colony. These were derived from DP rats in the fifth generation NIH Autoimmune Rat Model Repository and Dev Ctr inbred Extinct (as of 2021-02-22) RRID:RRRC_00094 1598803 BBNB/WorN Developed from a closed colony of outbred wistar rats which spontaneously developed autoimmune diabetes mellitus at the Bio-Breeding Laboratories, Ontario. University of Massachusetts Medical Center started inbreeding these in 1977. In 1983 NIH established a reference colony from this inbred colony. NIH Autoimmune Rat Model Repository and Dev Ctr, Rat Resource and Research Center inbred Unknown (as of 2020-02-24) RRID:RRRC_00093 1598804 WKY.GHS-(D1Rat32-D1Mit32) GHS females were crossed with WKY males and the heterozygous males were backcrossed to WKY females for 10 generations this resulted in introgressing a 100 cM region of chr 1 which contained the Hc1 QTL Department of Medicine and Physiology, University of Rochester, Rochester New York congenic Unknown 1 112148733 250430505 1 - by flanking markers 1 202649657 272443364 1 - by flanking markers 1 195598053 265002735 1 - by flanking markers 1 244113147 244113296 1 - by flanking markers RRID:RGD_1598804 1599674 BBDP.WF-(D8Rat59-D8Sunn1467)/Sunn WF RT7.2 allele was introgressed onto the genetic background of BBDP rats and these were crossed with BBDP Department of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada congenic Unknown 8 112242639 128970675 1 - by flanking markers 8 115112735 132425312 1 - by flanking markers 8 133272922 133273132 1 - by flanking markers 8 123815688 123815899 1 - by flanking markers RRID:RGD_1599674 1599675 BBDP.WF-(D13Rat124-D13Mgh5)/Sunn The BBDP/WorSunn rats were crossed with inbred WF rats (that share the same MHC haplotype as BBDP/WorSunn rats but differ at the CD45 allele) obtained from Charles River. Introgression of the WF CD45 (RT7.2) allele into BBDP/WorSunn was performed by phenotypic selection of backcross breeders for >10 generations, followed by intercrossing. This led to WF RT7.2 allele introgressed onto the genetic background of BBDP rats and also called BBDP/WorSunn.WF-CD45 inbred line. Department of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada congenic Unknown Ptprc 3451 13 46721037 63301552 1 - by flanking markers 13 55662705 71178960 1 - by flanking markers 13 50609228 66204630 1 - by flanking markers 13 45228358 61058078 1 - by flanking markers RRID:RGD_1599675 1599755 F344.BN-(D16Mit5-D16Rat75) BN/Crli was crossed with F344/Crli, F1 animals were backcrossed with F344 females three times to get ~25 cM region which corresponds to Hcs4 segment Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy congenic Unknown 16 24131965 24132402 1 - by flanking markers 16 24112631 24112769 1 - by flanking markers 16 24228228 24228366 1 - by flanking markers 16 22477482 22477621 1 - by flanking markers RRID:RGD_1599755 1599756 BN-Has2m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. Y344Stop mutation is generated from the codon change TAT/TAA. PGA mutant Unknown Has2m1Mcwi 1599566 7 93230135 93256139 1 - by flanking markers 7 97055458 97081461 1 - by flanking markers 7 96438046 96464049 1 - by flanking markers 7 88113326 88139337 1 - by flanking markers RRID:RGD_1599756 1599757 BN-Adora2am2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. Q310L mutation is generated from the codon change CAG/CTG of rat Adora2a. PhysGen mutant Extinct (as of 2016-10-24) Adora2am2Mcwi 1599561 20 13815719 13834131 1 - by flanking markers 20 16449385 16466147 1 - by flanking markers 20 14265251 14282873 1 - by flanking markers 20 13315848 13333386 1 - by flanking markers RRID:RGD_1599757 1599758 SS-Sod3m1Mcwi Male founders were injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups were genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. The E124D mutation was generated from the codon change GAG/GAT. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2021-11-03) Sod3m1Mcwi 1599567 14 63381447 63387180 1 - by flanking markers 14 61071304 61083776 1 - by flanking markers 14 60958583 60971143 1 - by flanking markers 14 58610104 58615845 1 - by flanking markers RRID:RRRC_00415 1599759 GRY/Idr groggy rat Groggy (gry) mutation was found in wistar rats at the Institute for Developmental Research, Aichi, in 1991. These were moved from the Institute for Developmental Research, Aichi Human Service Center to Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University , Kyoto in September 2003. National BioResource Project for the Rat in Japan, Graduate School of Medicine, Kyoto University Institute of Laboratory Animals, Kyoto Japan mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2021-02-12) Neurobiology Cacna1agry 12880382 19 25188170 25424495 1 - by flanking markers 19 36502533 36727039 1 - by flanking markers 19 25453236 25749550 1 - by flanking markers 19 23520741 23819971 1 - by flanking markers RRID:RGD_1599759 1599760 SPRD.WKY-(D18Wox8-D18Rat44)/Ibmm SPRD/HanZtm were crossed with WKY/Han and F1 males were backcrossed with SPRD/HanZtm. Heterozygous carriers were bred to SPRD/HanZtm. Universite Libre de Bruxelles, Institut de Biologie et de Medecine Moleculaires, Gosselies, Belgium congenic Unknown 18 19892650 86863412 1 - by flanking markers 18 20030289 86114102 1 - by flanking markers 18 20285758 87080053 1 - by flanking markers 18 19278901 83218561 1 - by flanking markers RRID:RGD_1599760 1599761 BN-Lcatm2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. D359E mutation is generated from the codon change GAC/GAG. PGA mutant Unknown Lcatm2Mcwi 1599570 19 35781507 35784966 1 - by flanking markers 19 48780364 48783830 1 - by flanking markers 19 37913333 37916799 1 - by flanking markers 19 33834748 33838214 1 - by flanking markers RRID:RGD_1599761 1599762 SS-Bdkrb2m2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. E178V mutation is generated from the codon change GAA/GTA. PGA mutant Unknown Bdkrb2m2Mcwi 1599568 6 129744781 129748851 1 - by flanking markers 6 138615812 138622272 1 - by flanking markers 6 129399468 129429676 1 - by flanking markers 6 124472317 124502497 1 - by flanking markers RRID:RGD_1599762 1599763 SPRD.WKY-(D5Rat190-D5Rat114)/Ibmm SPRD/HanZtm were crossed with WKY/Han and F1 males were backcrossed with SPRD/HanZtm. Heterozygous carriers were bred to SPRD/HanZtm. Universite Libre de Bruxelles, Institut de Biologie et de Medecine Moleculaires, Gosselies, Belgium congenic Unknown 5 24978084 24978263 1 - by flanking markers 5 29109097 29109277 1 - by flanking markers RRID:RGD_1599763 1599764 COP.DA-(D16Rat12-D16Rat90)/Mco Male COP/OlaHsd were crossed with female DA/OlaHsd then the F1 males were backcrossed to COP females. Male progeny containing the fewest number of DA-alleles were backcrossed to female COP. These males were backcrossed to female COP. University of Toledo College of Medicine, Toledo, Ohio congenic Unknown 16 350121 85734479 1 - by flanking markers 16 1084304 85597057 1 - by flanking markers 16 1090054 86162972 1 - by flanking markers 16 380245 80345693 1 - by flanking markers RRID:RGD_1599764 1599765 SS-Klf4m2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. I150N mutation is generated from the codon change ATC/AAC. PGA mutant Unknown Klf4m2Mcwi 1599559 5 73446928 73451286 1 - by flanking markers 5 76447643 76452001 1 - by flanking markers 5 72283311 72287669 1 - by flanking markers 5 70278843 70283751 1 - by flanking markers RRID:RGD_1599765 1599766 SS-Hps6m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. L67R mutation is generated from the codon change CTG/CGG. PGA mutant Unknown Hps6m1Mcwi 1599564 1 251226344 251228953 1 - by flanking markers 1 273191755 273194364 1 - by flanking markers 1 265761818 265764427 1 - by flanking markers 1 244853256 244855865 1 - by flanking markers RRID:RGD_1599766 1599767 SS-Htr1am2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. G76R mutation is generated from the codon change GGC/CGC. PGA mutant Unknown Htr1am2Mcwi 1599562 2 36434518 36435786 1 - by flanking markers 2 55362662 55363930 1 - by flanking markers 2 36246628 36247896 1 - by flanking markers 2 36694174 36695442 1 - by flanking markers RRID:RGD_1599767 1599768 SS-Klf4m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. V243I mutation is generated from the codon change GTC/ATC. PGA mutant Unknown Klf4m1Mcwi 1599569 5 73446928 73451286 1 - by flanking markers 5 76447643 76452001 1 - by flanking markers 5 72283311 72287669 1 - by flanking markers 5 70278843 70283751 1 - by flanking markers RRID:RGD_1599768 1599769 COP.DA-(D3Rat233-D3Mgh14)/Mco Male COP/OlaHsd were crossed with female DA/OlaHsd then the F1 males were backcrossed to COP females. Male progeny containing the fewest number of DA-alleles were backcrossed to female COP. These males were backcrossed to female COP. University of Toledo College of Medicine, Toledo, Ohio congenic Unknown 3 118863100 118863223 1 - by flanking markers 3 130198712 130198834 1 - by flanking markers 3 123700322 123700444 1 - by flanking markers 3 118376416 118376539 1 - by flanking markers RRID:RGD_1599769 1600337 F344.GK-(D1Mgh14-D1Rat90)/Swe This is a congenic substrain derived by intercrossing female F344/Crl and male F344.GK-(D1Arb42a-D1Rat90)/Swe. F2 progeny carried the homozygous GK/Swe genome in different segments. These were then maintained by bxs breeding. Karolinska Institutet, Stockholm, Sweden congenic Unknown 1 263698966 267111153 1 - by flanking markers 1 285604773 289137268 1 - by flanking markers 1 278228767 281795785 1 - by flanking markers 1 256448513 259647894 1 - by flanking markers RRID:RGD_1600337 1600338 SHR.F344-(D12Mgh5-D12Mgh6)/Snk Segment of chr 12 was introgressed from normotensive F344/Snk into SHR/Snk by the speed congenic technique Medicinal Safety Research Laboratories, Sankyo Co. Ltd., Shizuoka, Japan congenic Unknown 12 29130180 42387195 1 - by flanking markers 12 33647399 33647522 1 - by flanking markers 12 31723565 31723688 1 - by flanking markers 12 28064433 28064557 1 - by flanking markers RRID:RGD_1600338 1600339 BN.GK-(D1Wox18-D1Got254)/Ox This congenic strain is derived from GK rats which were from a colony in Paris (CNRS) obtained in 1995. BN rats were initially obtained from Charles River Laboratories, Margate, UK. The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK congenic Unknown 1 94626541 264367394 1 - by flanking markers 1 101198387 286341689 1 - by flanking markers 1 100133276 278978026 1 - by flanking markers 1 94644435 257091168 1 - by flanking markers RRID:RGD_1600339 1600340 DA/BklArbNsi Originally purchased from Bantin and Kingman, Fremont, California, maintained at the National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH. This was then transferred to Feinstein Institute for Medical Research at North Shore-LIJ, which was formerly known as North Shore-LIJ Research Institute, NSI. Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, NY, Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26) RRID:RRRC_00693 1600341 LEW-Tg(Ren2)27/Jmul This is a transgenic hypertensive rat strain, the mouse Ren2, renin gene is microinjected into fertilized eggs of LEW/Crl rats Wake Forest University School of Medicine, Winston-Salem, North Carolina transgenic Unknown RRID:RGD_1600341 1600342 F344.GK-(D1Got250-D1Rat90)/Swe This is a congenic substrain derived by intercrossing female F344/Crl and male F344.GK-(D1Arb42a-D1Rat90)/Swe. F2 progeny carried the homozygous GK/Swe genome in different segments. These were then maintained by bxs breeding. Karolinska Institutet, Stockholm, Sweden congenic Unknown 1 259168938 267111153 1 - by flanking markers 1 281200731 289137268 1 - by flanking markers 1 273787505 281795785 1 - by flanking markers 1 252080660 259647894 1 - by flanking markers RRID:RGD_1600342 1600343 SHRSP.WKY-(D1Wox29-D1Arb21)/Izm This congenic strain contains an WKY/Izm chromsome 1 segment containing a blood pressure QTL transferred to a SHRSP/Izm background by using speed congenic strategy National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 124614679 187092492 1 - by flanking markers 1 131822204 206277202 1 - by flanking markers 1 130779148 199254774 1 - by flanking markers 1 123350408 182418476 1 - by flanking markers RRID:RGD_1600343 1600344 F344.GK-(D1Rat175-D1Rat90)/Swe This is a congenic substrain derived by intercrossing female F344/Crl and male F344.GK-(D1Arb42a-D1Rat90)/Swe. F2 progeny carried the homozygous GK/Swe genome in different segments. These were then maintained by bxs breeding. Karolinska Institutet, Stockholm, Sweden congenic Unknown 1 267110921 267111153 1 - by flanking markers 1 289137107 289137268 1 - by flanking markers 1 281795624 281795785 1 - by flanking markers 1 259647732 259647894 1 - by flanking markers RRID:RGD_1600344 1600345 F344.GK-(D1Rat83-D1Rat376)/Swe This is a congenic substrain derived by intercrossing female F344/Crl and male F344.GK-(D1Arb42a-D1Rat90)/Swe. F2 progeny carried the homozygous GK/Swe genome in different segments. These were then maintained by bxs breeding. Karolinska Institutet, Stockholm, Sweden congenic Unknown 1 252133623 252133935 1 - by flanking markers 1 274017004 274017147 1 - by flanking markers 1 266587077 266587220 1 - by flanking markers 1 245700955 245701099 1 - by flanking markers RRID:RGD_1600345 1600346 F344.GK-(D1Swe4-D1Rat85)/Swe This is a congenic substrain derived by intercrossing female F344/Crl and male F344.GK-(D1Arb42a-D1Rat90)/Swe. F2 progeny carried the homozygous GK/Swe genome in different segments. These were then maintained by bxs breeding. Karolinska Institutet, Stockholm, Sweden congenic Unknown 1 255386328 258599658 1 - by flanking markers 1 277075545 280845045 1 - by flanking markers 1 269633949 273433763 1 - by flanking markers 1 248746112 251790570 1 - by flanking markers RRID:RGD_1600346 1600490 SS-Chr 1BN/Mcwi A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed PhysGen consomic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_1600490 1625284 Wild1/Hubr This rat was caught in the canals of Utrecht, The Netherlands and sacrificed for DNA isolation Hubrecht Laboratory, Utrecht, The Netherlands wild Unknown RRID:RGD_1625284 1626207 BN-Adora2am3Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. E207K mutation is generated from the codon change GAG/AAG of rat Adora2a. PhysGen mutant Extinct (as of 2016-10-24) Adora2am3Mcwi 1642070 20 13815719 13834131 1 - by flanking markers 20 16449385 16466147 1 - by flanking markers 20 14265251 14282873 1 - by flanking markers 20 13315848 13333386 1 - by flanking markers RRID:RGD_1626207 1626210 BN-Lipem2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. Q52L mutation is generated from the codon change CTG/CAG. PGA mutant Unknown Lipem2Mcwi 1642169 1 80663791 80682480 1 - by flanking markers 1 83511504 83530200 1 - by flanking markers 1 82248031 82266727 1 - by flanking markers 1 80965612 80984313 1 - by flanking markers RRID:RGD_1626210 1626211 SS-Cpf2m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. PGA mutant Unknown RRID:RGD_1626211 1626213 BN-Oxtrm1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. F225Y mutation is generated from the codon change TTC/TAC. PGA mutant Unknown Oxtrm1Mcwi 1642173 4 148314089 148326797 1 - by flanking markers 4 207701360 207717840 1 - by flanking markers 4 144399326 144417598 1 - by flanking markers 4 145598549 145614674 1 - by flanking markers RRID:RGD_1626213 1626214 BN-Slc27a5m2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. K160E mutation is generated from the codon change AAA/GAA. PGA mutant Unknown Slc27a5m2Mcwi 1642170 1 72924630 72935223 1 - by flanking markers 1 66387832 66398425 1 - by flanking markers 1 65576599 65587192 1 - by flanking markers 1 73616556 73627149 1 - by flanking markers RRID:RGD_1626214 1641831 MWF-Chr 6SHR/Rkb MWF/FubRkb male was crossed with female SHR/FubRkb to get F1 animals which in turn were backcrossed with female MWF/FubRkb to preserve the Y chromosome, this was repeated for 7 generations, tested by sequential marker-assisted backcrossing Department of Clinical Pharmacology and Toxicology, Charite-Universitatsmedizin Berlin, Berlin, Germany consomic Unknown RRID:RGD_1641831 1641849 SS.LEW-(D10Mit1-D10Mgh1)/Jr This is a congenic substrain developed by crossing SS.LEW-(D10Mit10-D10Mgh1/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 95368898 95369088 1 - by flanking markers 10 93929621 93929812 1 - by flanking markers RRID:RGD_1641849 1641850 SHR.WKY-(D1Got158-D1Got161)/Njs This is a congenic substrain developed by crossing SHR.WKY-(D1Wox34-D1Rat164)/Njs to SHR to get F2 which were again crossed with SHR to duplicate the recombinant region Department of Cardiovascular Sciences , University of Leicester, Glenfield Hospital, UK congenic Unknown Spon1 619918 1 169571535 169571693 1 - by flanking markers 1 183593063 183593220 1 - by flanking markers 1 176611942 176612099 1 - by flanking markers 1 165908744 165908902 1 - by flanking markers RRID:RGD_1641850 1641851 SHR.PD-(D8Rat42-D8Arb23)/Cub A differential segment of chr 8 from PD/Cub is introgressed onto the genetic background of SHR/OlaIpcv by narrowing down the segment in SHR-Lx strain Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic congenic Unknown Zbtb16|Zbtb16Lx 727921|12910834 8 51376771 52822796 1 - by flanking markers 8 51046971 52459221 1 - by flanking markers 8 52446316 53840120 1 - by flanking markers 8 48432652 49868959 1 - by flanking markers RRID:RGD_1641851 1641852 WF.BBDR-(D4Got48-D4Got43)/Wor This congenic substrain was generated by the marker-assisted protocol where a segment of WF.BBDR-(D4Rat96-D4Rat44)/Wor were transferred to WF background and the animals were screened using microsatellite markers. University of Massachusetts Medical School, Worcerster, MA congenic Unknown 4 65628995 68036772 1 - by flanking markers 4 65594194 133430955 1 - by flanking markers 4 65776688 68645203 1 - by flanking markers 4 66800270 69276226 1 - by flanking markers RRID:RGD_1641852 1641853 SS.LEW-(D10Mco38-D10Mgh1)/Jr This is a congenic substrain developed by crossing SS.LEW-(D10Mit10-D10Mgh1/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 65068360 65122086 1 - by flanking markers 10 65339106 66856515 1 - by flanking markers RRID:RGD_1641853 1641854 HAS.LAS-(D5Rat70-D5Rat37)/Rar HAS1 (RGD:1578700) and LAS1(RGD:1578696) rats were reciprocally mated to produce an F1 generation. Congenics were bred by backcrossing F1 male to HAS1 and the offsprings were genotyped, Department of Pharmaceutical Sciences, University of Colorado at Denver, Denver, Colorado congenic Unknown 5 36386126 148460381 1 - by flanking markers 5 40446731 151220567 1 - by flanking markers 5 35788756 147487820 1 - by flanking markers 5 35189153 141643988 1 - by flanking markers RRID:RGD_1641854 1641855 BBDP.WF-(D8Rat73-D8Rat20)/Sunn WF RT7.2 allele was introgressed onto the genetic background of BBDP rats and these were crossed with BBDP Department of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada congenic Unknown 8 92863340 94870319 1 - by flanking markers 8 94761016 96840283 1 - by flanking markers 8 95257972 97339444 1 - by flanking markers 8 88552647 90508589 1 - by flanking markers RRID:RGD_1641855 1641856 P.NP-(D4Rat119-D4Rat55)/Iusm iP and iNP rats were backcrossed to get F1 animals which were further backcrossed to P rats for 10 generations, this was followed by intercross to generate the congenic strains, these animals were selected by marker-assisted selection Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana congenic Unknown 4 62832008 127941994 1 - by flanking markers 4 190188458 190188644 1 - by flanking markers 4 62947687 125671711 1 - by flanking markers 4 126192368 126192555 1 - by flanking markers RRID:RGD_1641856 1641857 BBDP.WF-(D8Rat16-D8Sunn1467)/Sunn WF RT7.2 allele was introgressed onto the genetic background of BBDP rats and these were crossed with BBDP Department of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada congenic Unknown 8 98878516 128970675 1 - by flanking markers 8 100780886 132425312 1 - by flanking markers 8 101304999 133273132 1 - by flanking markers 8 94388671 123815899 1 - by flanking markers RRID:RGD_1641857 1641858 SHR.WKY-(D1Rat420-D1Rat278)/Njs This is a congenic substrain developed by crossing SHR.WKY-(D1Wox34-D1Rat164)/Njs to SHR to get F2 which were again crossed with SHR to duplicate the recombinant region Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, UK congenic Unknown 1 167931247 168930831 1 - by flanking markers 1 181904343 182965674 1 - by flanking markers 1 174905726 175980872 1 - by flanking markers 1 164310419 165279420 1 - by flanking markers RRID:RGD_1641858 1641859 SS.MNS-(D10Bra1-D10Mit11)/Jr This is a congenic substrain developed by crossing SS.MNS-(D10M11Mit119-D10Mit11/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 101848470 101848683 1 - by flanking markers RRID:RGD_1641859 1641860 SS.MNS-(D10Mco62-D10Mit1)/Jr This is a congenic substrain developed by crossing SS.MNS-(D10M11Mit119-D10Mit11/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 72063231 95369088 1 - by flanking markers 10 70763267 93929812 1 - by flanking markers RRID:RGD_1641860 1641861 HAS.LAS-(D2Rat53-D2Rat138)/Rar HAS1 (RGD:1578700) and LAS1(RGD:1578696) rats were reciprocally mated to produce an F1 generation. Congenics were bred by backcrossing F1 male to HAS1 and the offsprings were genotyped, Department of Pharmaceutical Sciences, University of Colorado at Denver, Denver, Colorado, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-26) 2 204077549 230157845 1 - by flanking markers 2 230770662 256283467 1 - by flanking markers 2 211301116 237742948 1 - by flanking markers 2 196146703 221167075 1 - by flanking markers RRID:RRRC_00729 1641862 F344-ApcPirc/Uwm Male F344/NTac rats were injected with ENU (N-ethyl-N-nitrosourea) and then bred. Phenotypically variant pups were screened. A to T transversion at nucleotide 3409 of the coding sequence. (AAG.TAG) Amino acid 1137 (K.Xam) University of Wisconsin-Madison, Madison, Wisconsin, Rat Resource and Research Center mutant Live Animals; Cryopreserved Sperm (as of 2018-07-16) ApcPirc 1554322 18 26732147 26790383 1 - by flanking markers 18 26725560 26820837 1 - by flanking markers 18 27011710 27106323 1 - by flanking markers 18 25828558 25925511 1 - by flanking markers RRID:RRRC_00782 1641863 SHR.PD-(D8Mgh9-D8Rat149)/Cub A differential segment of chr 8 from PD/Cub is introgressed onto the genetic background of SHR/OlaIpcv. Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic congenic Unknown Zbtb16|Zbtb16Lx 727921|12910834 8 58692901 58693265 1 - by flanking markers 8 58297648 58297798 1 - by flanking markers 8 59716199 59716349 1 - by flanking markers 8 55523877 55524028 1 - by flanking markers RRID:RGD_1641863 1641864 WF/CrCrli J. Furth in 1945 from a commercial Wistar stock in an attempt to develop a high leukemia rat strain. To Charles River in 1998 from the National Cancer Institute. Charles River Laboratories Italy inbred Unknown RRID:RGD_1641864 1641865 SD-Brca2m1Uwm 9 week-old male rats were injected with ENU (N-ethyl-N-nitrosourea) and then bred. Phenotypically variant pups were visually identified and screened. Nonsense transversion mutation at nucleotide T4254 that converted TAT (tyrosine) to TAA (stop codon). University of Wisconsin-Madison, Madison, Wisconsin, Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2016-12-01) Brca2m1Uwm 728326 12 4282952 4323693 1 - by flanking markers 12 490733 535090 1 - by flanking markers 12 503660 544754 1 - by flanking markers 12 59492 103789 1 - by flanking markers RRID:RRRC_00286 1641866 SS.LEW-(D10Mit10-D10Rat24)/Jr This is a congenic substrain developed by crossing SS.LEW-(D10Mit10-D10Mgh1/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 27184741 79229233 1 - by flanking markers 10 27082535 78195122 1 - by flanking markers 10 27237530 78343192 1 - by flanking markers 10 26521957 75632053 1 - by flanking markers RRID:RGD_1641866 1641867 Iusm:P alcohol-preferring These were developed at Indiana University for alcohol-preferring behavior through bidirectional selective breeding of Wistar rats from the Walter Reed Army Institute of Research, Washington, DC. A single pair of rats with high preference and another pair with low preference were mated to develop this preference line (P) and non-preference line (Iusm:NP, RGD:1641873). Indiana Alcohol Research Center at the Indiana University School of Medicine outbred Unknown Snca 3729 RRID:RGD_1641867 1641868 WF.BBDR-(D4Rat93-D4Rat228)/Wor This congenic substrain was generated by the marker-assisted protocol where a segment of WF.BBDR-(D4Rat96-D4Rat44)/Wor were transferred to WF background and the animals were screened using microsatellite markers. University of Massachusetts Medical School, Worcerster, MA congenic Unknown Tcrb 3834 4 67390393 67390598 1 - by flanking markers 4 67470286 67470490 1 - by flanking markers 4 67663300 67663504 1 - by flanking markers 4 68653456 68653663 1 - by flanking markers RRID:RGD_1641868 1641869 SS.MNS-(D10Mco31-D10Mit11)/Jr This is a congenic substrain developed by crossing SS.MNS-(D10M11Mit119-D10Mit11/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 84284413 101848683 1 - by flanking markers 10 83219971 83220224 1 - by flanking markers 10 83411403 83411656 1 - by flanking markers 10 80536974 80537228 1 - by flanking markers RRID:RGD_1641869 1641870 BBDP.WF-(D8Rat73-D8Rat121)/Sunn WF RT7.2 allele was introgressed onto the genetic background of BBDP rats and these were crossed with BBDP Department of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada congenic Unknown 8 92863340 118705380 1 - by flanking markers 8 94761016 121648073 1 - by flanking markers 8 95257972 95258175 1 - by flanking markers 8 88552647 88552853 1 - by flanking markers RRID:RGD_1641870 1641871 SS.MNS-(D10Mco62-D10Mco31)/Jr This is a congenic substrain developed by crossing SS.MNS-(D10M11Mit119-D10Mit11/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 72063231 84284667 1 - by flanking markers 10 70763267 83220224 1 - by flanking markers 10 83411403 83411656 1 - by flanking markers 10 80536974 80537228 1 - by flanking markers RRID:RGD_1641871 1641872 SS.LEW-(D10Mco38-D10Mco41)/Jr This is a congenic substrain developed by crossing SS.LEW-(D10Mit10-D10Mgh1/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 65068360 85793448 1 - by flanking markers 10 65339106 84798381 1 - by flanking markers 10 85007626 85007896 1 - by flanking markers 10 82057244 82057515 1 - by flanking markers RRID:RGD_1641872 1641873 Iusm:NP alcohol-nonpreferring These were developed at Indiana University for alcohol-preferring behavior through bidirectional selective breeding of Wistar rats from the Walter Reed Army Institute of Research, Washington, DC. A single pair of rats with high preference and another pair with low preference were mated to develop a preference line (Iusm:P, RGD:1641867) and this non-preference line (Iusm:NP). Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana outbred Unknown Snca 3729 RRID:RGD_1641873 1641874 BBDP.WF-(D8Rat73-D8Rat90)/Sunn WF RT7.2 allele was introgressed onto the genetic background of BBDP rats and these were crossed with BBDP Department of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada congenic Unknown 8 92863340 114974688 1 - by flanking markers 8 94761016 118204000 1 - by flanking markers 8 95257972 118862813 1 - by flanking markers 8 88552647 110572221 1 - by flanking markers RRID:RGD_1641874 1641875 SHR-Chr YBN/Cub BN-Lx/Cub males were crosssed with SHR/OlaIpcv females to get F1 animals, the hybrid animals were backcrossed with female SHR/OlaIpcv for 8 generations Czech Academy of Sciences, Prague, Czech Republic consomic Unknown RRID:RGD_1641875 1641876 BBDP.WF-(D8Rat73-D8Sunn1467)/Sunn WF RT7.2 allele was introgressed onto the genetic background of BBDP rats and these were crossed with BBDP Department of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada congenic Unknown 8 92863340 128970675 1 - by flanking markers 8 94761016 132425312 1 - by flanking markers 8 95257972 133273132 1 - by flanking markers 8 88552647 123815899 1 - by flanking markers RRID:RGD_1641876 1641877 NP.P-(D4Rat119-D4Rat55)/Iusm Male iP and female iNP rats were crossed to get F1 animals which were further backcrossed to iNP rats for 10 generations, this was followed by intercross to generate the congenic strains, these animals were selected by marker-assisted selection Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana congenic Unknown Akr1b1|Npy|Snca|Grid2|Dgki|Zfp212|Ppm1k|Sos1|Baiap1 2092|3197|3729|68368|735049|1307836|1308501|1310949|1311418 4 62832008 127941994 1 - by flanking markers 4 190188458 190188644 1 - by flanking markers 4 62947687 125671711 1 - by flanking markers 4 126192368 126192555 1 - by flanking markers RRID:RGD_1641877 1641878 WF.BBDR-(Clcn1-D4Rat228)/Wor This congenic substrain was generated by the marker-assisted protocol where a segment of WF.BBDR-(D4Rat96-D4Rat44)/Wor were transferred to WF background and the animals were screened using microsatellite markers. University of Massachusetts Medical School, Worcerster, MA congenic Unknown Clcn1 2360 4 70052319 70081449 1 - by flanking markers 4 136479719 136509472 1 - by flanking markers 4 71674218 71704318 1 - by flanking markers 4 71171949 71201483 1 - by flanking markers RRID:RGD_1641878 1641879 SS-Chr 19SHR/Rkb SS/JrRkb male was crossed with female SHR/FubRkb to get F1 animals which in turn were backcrossed with female SS/JrRkb to preserve the Y chromosome, this was repeated for 7 generations, tested by sequential marker-assisted backcrossing Department of Clinical Pharmacology and Toxicology, Charite-Universitatsmedizin Berlin, Berlin, Germany consomic Unknown RRID:RGD_1641879 1641880 SD-Brca1m1Uwm 9 week-old male rats were injected with ENU (N-ethyl-N-nitrosourea) and then bred. Phenotypically variant pups were visually identified and screened. mutation from A to G at the exon 21/22 border causes a frameshift and premature stop codon. University of Wisconsin-Madison, Madison, Wisconsin, Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2016-12-01) Brca1|Brca1m1Uwm 2218|728298 10 90513630 90572676 1 - by flanking markers 10 89192653 89252760 1 - by flanking markers 10 89394821 89455093 1 - by flanking markers 10 86417441 86477762 1 - by flanking markers RRID:RRRC_00285 1642017 BBDR/WorBrm Diabetes resistant BB rats maintained in BRM. This strain has been maintained by brother and sister mating for 40 generations. These originated from the Worcester colony from the rats that were sent from Ottawa to Worcester in 1977. These are derived from a viral antibody free (VAF)colony which was maintained at University of Massachusetts and is now at Biomedical Research Models, Inc. Biomedical Research Models, Inc. inbred Unknown RRID:RGD_1642017 1642018 BBDP/WorBrm This strain has been maintained by brother and sister mating for 40 generations. These originated from the Worcester colony from the rats that were sent from Ottawa to Worcester in 1977. Biomedical Research Models, Inc. got these from Worcester. Biomedical Research Models, Inc. inbred Unknown RRID:RGD_1642018 1642036 SHR/OlaIpcv-mtBN/Crl Mitochodrial genome of SHR/OlaIpcv was selectively replaced by BN/Crl to create this conplastic strain using the supersonic breeding strategy; these have the mitochondrial genome of BN/Crl on SHR/OlaIpcv nuclear genetic background Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic conplastic Unknown RRID:RGD_1642036 1642269 SS-Birc3m2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. K170E mutation is generated from the codon change AAG/GAG. PhysGen mutant Extinct (as of 2017-01-26) Birc3m2Mcwi 1642178 8 4682202 4696856 1 - by flanking markers 8 6047454 6075236 1 - by flanking markers 8 6048590 6076828 1 - by flanking markers 8 5000844 5028470 1 - by flanking markers RRID:RGD_1642269 1642270 BN-Lcatm3Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. H316N mutation is generated from the codon change CAC/AAC. PGA, Rat Resource & Research Center mutant Cryopreserved Sperm; Cryorecovery Lcatm3Mcwi 1642175 19 35781507 35784966 1 - by flanking markers 19 48780364 48783830 1 - by flanking markers 19 37913333 37916799 1 - by flanking markers 19 33834748 33838214 1 - by flanking markers RRID:RRRC_00397 1642271 SS-Klf4m3Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. H344L mutation is generated from the codon change CAT/CTT. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Klf4m3Mcwi 1642179 5 73446928 73451286 1 - by flanking markers 5 76447643 76452001 1 - by flanking markers 5 72283311 72287669 1 - by flanking markers 5 70278843 70283751 1 - by flanking markers RRID:RRRC_00417 1642272 SS.LEW-(D10Mco84-D10Got93)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Rat29-D10Got93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 70757255 72827158 1 - by flanking markers 10 69542746 71779712 1 - by flanking markers 10 69910832 71870652 1 - by flanking markers 10 67502108 69424978 1 - by flanking markers RRID:RGD_1642272 1642273 SS-Thbdm1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. N256K mutation is generated from the codon change AAC/AAA. PhysGen mutant Extinct (as of 2017-01-26) Thbdm1Mcwi 1642182 3 137158955 137162607 1 - by flanking markers 3 149159895 149163547 1 - by flanking markers 3 142748673 142752325 1 - by flanking markers 3 135863366 135867018 1 - by flanking markers RRID:RGD_1642273 1642274 SS-Has1m2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. V155L mutation is generated from the codon change GTC/CTC. PhysGen mutant Extinct (as of 2017-01-26) Has1m2Mcwi 1642171 1 56503365 56516133 1 - by flanking markers 1 60640270 60652067 1 - by flanking markers 1 59720612 59732409 1 - by flanking markers 1 58693411 58705653 1 - by flanking markers RRID:RGD_1642274 1642275 SS.LEW-(D10Rat29-D10Mco88)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Rat29-D10Got93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 68842878 71513333 1 - by flanking markers 10 67642121 71109330 1 - by flanking markers 10 67988035 70647306 1 - by flanking markers 10 68230134 68230352 1 - by flanking markers RRID:RGD_1642275 1642276 SS-Kcna5m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. N152K mutation is generated from the codon change AAT/AAA. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Kcna5m1Mcwi 1642177 4 162896283 162898091 1 - by flanking markers 4 226075051 226076859 1 - by flanking markers 4 159077195 159079003 1 - by flanking markers 4 159354689 159358173 1 - by flanking markers RRID:RRRC_00418 1642277 SS-Cpt2m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. F475L mutation is generated from the codon change TTC/CTC. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Cpt2m1Mcwi 1642174 5 129007685 129025501 1 - by flanking markers 5 131353542 131370821 1 - by flanking markers 5 127505646 127523016 1 - by flanking markers 5 122664677 122682126 1 - by flanking markers RRID:RRRC_00416 1642278 SS-Ghsrm2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. S342P mutation is generated from the codon change TCC/CCC. PhysGen mutant Extinct (as of 2017-01-26) Ghsrm2Mcwi 1642180 2 113269623 113272999 1 - by flanking markers 2 132784207 132789319 1 - by flanking markers 2 113065953 113071265 1 - by flanking markers 2 110268489 110271865 1 - by flanking markers RRID:RGD_1642278 1642279 SS.LEW-(D10Arb9-D10Rat161)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Arb9-D10Got101)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 64308668 97589703 1 - by flanking markers 10 66048908 96133217 1 - by flanking markers 10 65590122 65590250 1 - by flanking markers 10 63221094 63221223 1 - by flanking markers RRID:RGD_1642279 1642281 SS-Podxlm1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. T154A mutation is generated from the codon change ACA/GCA. PhysGen mutant Extinct (as of 2017-01-26) Podxlm1Mcwi 1642176 4 58611904 58658598 1 - by flanking markers 4 58581513 58645671 1 - by flanking markers 4 58829049 58893353 1 - by flanking markers 4 60135124 60181829 1 - by flanking markers RRID:RGD_1642281 1642282 SS-Cacna1gm1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. S490T mutation is generated from the codon change TCT/ACT. PGA mutant Unknown Cacna1gm1Mcwi 1642168 10 83043636 83112886 1 - by flanking markers 10 81950594 82017885 1 - by flanking markers 10 82129071 82197828 1 - by flanking markers 10 79354998 79422960 1 - by flanking markers RRID:RGD_1642282 1642283 SS.LEW-(D10Rat29-D10Got93)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Arb9-D10Got101)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 68842878 72827158 1 - by flanking markers 10 67642121 71779712 1 - by flanking markers 10 67988035 71870652 1 - by flanking markers 10 69424852 69424978 1 - by flanking markers RRID:RGD_1642283 1642284 SS-Fgl2m2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. K129N mutation is generated from the codon change AAG/AAT. PGA mutant Unknown Fgl2m2Mcwi 1642181 4 9176333 9181976 1 - by flanking markers 4 10315666 10321309 1 - by flanking markers 4 10323598 10329241 1 - by flanking markers 4 13710566 13716207 1 - by flanking markers RRID:RGD_1642284 1642285 SS.LEW-(D10Arb9-D10Rat57)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Arb9-D10Got101)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 64308668 74388696 1 - by flanking markers 10 66048908 73484175 1 - by flanking markers 10 65590122 73582866 1 - by flanking markers 10 63221094 70982751 1 - by flanking markers RRID:RGD_1642285 1642287 SS.LEW-(D10Arb9-D10Mco84)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Arb9-D10Got101)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 64308668 70757419 1 - by flanking markers 10 66048908 69542910 1 - by flanking markers 10 65590122 69910996 1 - by flanking markers 10 63221094 67502273 1 - by flanking markers RRID:RGD_1642287 1642288 SS.LEW-(D10Mco89-D10Got101)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Arb9-D10Got101)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 72684998 78262332 1 - by flanking markers 10 71638135 77223025 1 - by flanking markers 10 71727774 77360263 1 - by flanking markers 10 69282350 74676620 1 - by flanking markers RRID:RGD_1642288 1642289 SS-Serpina5m1Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. H24R mutation is generated from the codon change CAT/CGT. PGA mutant Unknown Serpina5m1Mcwi 1642167 6 128156901 128161334 1 - by flanking markers 6 136972583 136990812 1 - by flanking markers 6 127753152 127772403 1 - by flanking markers 6 123009224 123028412 1 - by flanking markers RRID:RGD_1642289 1642362 SS-Has1m3Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. D167D mutation is generated from the codon change GAT/GAC. PGA mutant Unknown Has1m3Mcwi 1642359 1 56503365 56516133 1 - by flanking markers 1 60640270 60652067 1 - by flanking markers 1 59720612 59732409 1 - by flanking markers 1 58693411 58705653 1 - by flanking markers RRID:RGD_1642362 1642363 BN-Fgl2m3Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. N353H mutation is generated from the codon change AAT/CAT. PGA mutant Unknown Fgl2m3Mcwi 1642355 4 9176333 9181976 1 - by flanking markers 4 10315666 10321309 1 - by flanking markers 4 10323598 10329241 1 - by flanking markers 4 13710566 13716207 1 - by flanking markers RRID:RGD_1642363 1642364 SS-Ghsrm3Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. N26K mutation is generated from the codon change AAC/AAA. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Ghsrm3Mcwi 1642357 2 113269623 113272999 1 - by flanking markers 2 132784207 132789319 1 - by flanking markers 2 113065953 113071265 1 - by flanking markers 2 110268489 110271865 1 - by flanking markers RRID:RRRC_00421 1642365 SS-Fgl2m4Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. H338P mutation is generated from the codon change CAT/CCT. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Fgl2m4Mcwi 1642354 4 9176333 9181976 1 - by flanking markers 4 10315666 10321309 1 - by flanking markers 4 10323598 10329241 1 - by flanking markers 4 13710566 13716207 1 - by flanking markers RRID:RRRC_00420 1642366 SS-Lcatm4Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. Y336N mutation is generated from the codon change TAT/AAT. PhysGen, Rat Resource & Research Center mutant Extinct (as of 2017-01-26) Lcatm4Mcwi 1642358 19 35781507 35784966 1 - by flanking markers 19 48780364 48783830 1 - by flanking markers 19 37913333 37916799 1 - by flanking markers 19 33834748 33838214 1 - by flanking markers RRID:RGD_1642366 1642367 BN-Ccr2m2Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. I99T mutation is generated from the codon change ATC/ACC. PhysGen mutant Extinct (as of 2017-01-26) Ccr2m2Mcwi 1642356 8 128892784 128893905 1 - by flanking markers 8 123734465 123742483 1 - by flanking markers RRID:RGD_1642367 1642439 SS-Lcatm5Mcwi Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. Y297Stop mutation is generated from the codon change TAC/TAA. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Lcatm5Mcwi 1642438 19 35781507 35784966 1 - by flanking markers 19 48780364 48783830 1 - by flanking markers 19 37913333 37916799 1 - by flanking markers 19 33834748 33838214 1 - by flanking markers RRID:RRRC_00419 1642689 BN.OLETF-(D1Rat169-D1Rat90)/Got OLETF/Got females were crossed with BN/Crlj to produce F1 which were backcrossed to BN/Crlj, animals with Dmo1 locus (~28.8 cM) were genotyped Otsuka Pharmacuetical Company, Tokushima, Japan congenic Unknown Prlhr 71037 1 229876870 267111153 1 - by flanking markers 1 251652807 289137268 1 - by flanking markers 1 244401175 281795785 1 - by flanking markers 1 224054293 259647894 1 - by flanking markers RRID:RGD_1642689 1642690 LA-cp/NJcr Originated from a cross between ALB/N and a hooded stock of unknown origin; maintained at University of Alberta. Department of Surgery, University of Alberta, Edmonton, Canada congenic Unknown RRID:RGD_1642690 1642968 SS.LEW-(D10Mco84-D10Rat58)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Mco84-D10Got93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 70757255 71067824 1 - by flanking markers 10 69542746 70966782 1 - by flanking markers 10 69910832 70202084 1 - by flanking markers 10 67502108 67785171 1 - by flanking markers RRID:RGD_1642968 1642969 SS.LEW-(D10Mco84-D10Mco134)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Mco84-D10Got93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 70757255 70757419 1 - by flanking markers 10 69542746 69542910 1 - by flanking markers 10 69910832 69910996 1 - by flanking markers 10 67502108 67502273 1 - by flanking markers RRID:RGD_1642969 1642970 SS.LEW-(D10Mco113-D10Got93)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Mco84-D10Got93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 72827032 72827158 1 - by flanking markers 10 71779587 71779712 1 - by flanking markers 10 71870527 71870652 1 - by flanking markers 10 69424852 69424978 1 - by flanking markers RRID:RGD_1642970 1642971 SS.LEW-(D10Mco84-D10Mco129)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Mco84-D10Got93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 70757255 70757419 1 - by flanking markers 10 69542746 69542910 1 - by flanking markers 10 69910832 69910996 1 - by flanking markers 10 67502108 67502273 1 - by flanking markers RRID:RGD_1642971 1642972 SS.LEW-(D10Mco84-D10Mco143)/Mco This is a congenic substrain developed by crossing SS.LEW-(D10Mco84-D10Got93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 70757255 70757419 1 - by flanking markers 10 69542746 69542910 1 - by flanking markers 10 69910832 69910996 1 - by flanking markers 10 67502108 67502273 1 - by flanking markers RRID:RGD_1642972 1642989 SS-Tg(CAG-EGFP)1Mcwi This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SS rat embryos. Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Cryopreserved Sperm (as of 2019-04-04) RRID:RGD_1642989 1642990 SD-Tg(CAG-EGFP)63Mcwi This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SD rat embryos. Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_1642990 1642991 SS-Tg(CAG-eGFP)18Mcwi This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SS rat embryos. Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_1642991 1642992 SS-Tg(CAG-EGFP)28Mcwi This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SS rat embryos. Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_1642992 1642993 SD-Tg(CAG-EGFP)97Mcwi This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SD rat embryos. Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_1642993 1642994 SS-Tg(CAG-EGFP)43Mcwi This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SS rat embryos. Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_1642994 1642995 SS-Tg(CAG-eGFP)10Mcwi This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SS rat embryos. Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_1642995 1642996 SS-Tg(CAG-EGFP)2Mcwi This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SS rat embryos. Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_1642996 1642997 SS-Tg(CAG-EGFP)23Mcwi This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SS rat embryos. Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_1642997 1643001 FH/Unc Fawn-hooded A substrain of fawn hooded rat, maintained at Universtiy of North Carolina, Chapel Hill Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina inbred Unknown RRID:RGD_1643001 1643002 SHR.WKY-(D1Rat420-D1Got161)/Njs Fragment of the chromosome 1 derived from WKY and repeated backcross to SHR Dept. Cardiology, Univ of Leicester, Clinical Sciences Wing. Glenfield Hospital, Groby Rd, Leicester, UK congenic Unknown Spon1 619918 1 167931247 167931390 1 - by flanking markers 1 181904343 181904486 1 - by flanking markers 1 174905726 174905869 1 - by flanking markers 1 164310419 164310563 1 - by flanking markers RRID:RGD_1643002 1643007 DA.ACI-(D12Wox12-D12Rat53)/Arb ACI/SegHsd and DA/OlaHsd were crossed to get F2 animals which were backcrossed with DA/OlaHsd and the progeny genotyped then backcrossed with DA/OlaHsd The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown 12 20932555 43863270 1 - by flanking markers 12 24663002 50380790 1 - by flanking markers 12 22650721 48598906 1 - by flanking markers 12 19610889 42828880 1 - by flanking markers RRID:RGD_1643007 1643010 F344.OLETF-(D7Rat18-D7Mit2)(D14Rat23-D14Rat12)/Tj double congenic strain generated by intercrossing F344.OLETF-(D7Rat18-D7Mit2)/Tj and F344.OLETF-(D14Rat23-D14Rat12)/Tj and F2 rats screened for homozygosity University of Tokushima Graduate School, Kuramato-cho, Tokushima, Japan congenic Unknown RRID:RGD_1643010 2289819 SS.MNS-(D10Mco62-D10Got99)/Mco This is a congenic substrain developed by crossing SS.MNS-(D10M11Mit119-D10Mit11)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 72063231 76465800 1 - by flanking markers 10 70763267 74612561 1 - by flanking markers 10 75493824 75493944 1 - by flanking markers 10 72964095 72964216 1 - by flanking markers RRID:RGD_2289819 2289820 SS.MNS-(D10Mco30-D10Got91)/1Mco This is a congenic substrain developed by crossing SS.MNS-(D10Mco30-D10Mco31)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 77547289 78112169 1 - by flanking markers 10 73693979 77074440 1 - by flanking markers 10 76420583 77211758 1 - by flanking markers 10 73887148 73887455 1 - by flanking markers RRID:RGD_2289820 2289821 SS.MNS-(D10Mco30-D10Got91)/3Mco This is a congenic substrain developed by crossing SS.MNS-(D10Mco30-D10Mco31)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 77547289 78112169 1 - by flanking markers 10 73693979 77074440 1 - by flanking markers 10 76420583 77211758 1 - by flanking markers 10 73887148 73887455 1 - by flanking markers RRID:RGD_2289821 2289822 SS.MNS-(D10Mco30-D10Got112)/Mco This is a congenic substrain developed by crossing SS.MNS-(D10Mco30-D10Mco31)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 77547289 79857935 1 - by flanking markers 10 73693979 78816367 1 - by flanking markers 10 76420583 78970405 1 - by flanking markers 10 73887148 76246212 1 - by flanking markers RRID:RGD_2289822 2289823 SS.MNS-(D10Mco62-D10Mco30)/Mco This is a congenic substrain developed by crossing SS.MNS-(D10M11Mit119-D10Mit11)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 72063231 77547622 1 - by flanking markers 10 70763267 73694285 1 - by flanking markers 10 76420583 76420889 1 - by flanking markers 10 73887148 73887455 1 - by flanking markers RRID:RGD_2289823 2289824 SS.MNS-(D10Mco30-D10Got101)/Mco This is a congenic substrain developed by crossing SS.MNS-(D10Mco30-D10Mco31)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 77547289 78262332 1 - by flanking markers 10 73693979 77223025 1 - by flanking markers 10 76420583 77360263 1 - by flanking markers 10 73887148 74676620 1 - by flanking markers RRID:RGD_2289824 2289825 SS.MNS-(D10Rat24-D10Mco31)/Jr This is a congenic substrain developed by crossing SS.MNS-(D10Mco62-D10Mco31)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 79229067 84284667 1 - by flanking markers 10 78194957 83220224 1 - by flanking markers 10 78343027 83411656 1 - by flanking markers 10 75631887 80537228 1 - by flanking markers RRID:RGD_2289825 2289826 SS.MNS-(D10Mco30-D10Got91)/2Mco This is a congenic substrain developed by crossing SS.MNS-(D10Mco30-D10Mco31)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 77547289 78112169 1 - by flanking markers 10 73693979 77074440 1 - by flanking markers 10 76420583 77211758 1 - by flanking markers 10 73887148 73887455 1 - by flanking markers RRID:RGD_2289826 2289827 SS.MNS-(D10Mco30-D10Mco31)/Jr This is a congenic substrain developed by crossing SS.MNS-(D10Mco62-D10Mco31)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 10 77547289 84284667 1 - by flanking markers 10 73693979 83220224 1 - by flanking markers 10 76420583 83411656 1 - by flanking markers 10 73887148 80537228 1 - by flanking markers RRID:RGD_2289827 2289913 SS.MNS-(D10Rat13-D10Rat12)/Jr This is a congenic substrain developed by crossing SS.MNS-(D10Rat13-D10Mit11)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo congenic Unknown 10 97152234 99198997 1 - by flanking markers 10 95701164 97759008 1 - by flanking markers 10 95967019 98044833 1 - by flanking markers 10 92698959 94725019 1 - by flanking markers RRID:RGD_2289913 2289916 SS.MNS-(D10Mco15-D10Mit11)/Jr This is a congenic substrain developed by crossing SS.MNS-(D10Rat13-D10Mit11)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo congenic Unknown 10 98392296 101848683 1 - by flanking markers 10 97028717 97028928 1 - by flanking markers 10 97308358 97308569 1 - by flanking markers 10 93995749 93995963 1 - by flanking markers RRID:RGD_2289916 2289917 SS.MNS-(D10Mco70-D10Mit11)/Jr This is a congenic substrain developed by crossing SS.MNS-(D10Rat13-D10Mit11)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo congenic Unknown 10 101355656 101848683 1 - by flanking markers 10 99976910 99977168 1 - by flanking markers 10 100287441 100287699 1 - by flanking markers 10 96836006 96836268 1 - by flanking markers RRID:RGD_2289917 2290056 F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 4th intron of the Rbed1 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Elmod3Tn(sb-T2/Bart3)2.42Mcwi 2290055 4 105866419 106099850 1 - by flanking markers 4 165192607 165237016 1 - by flanking markers 4 100422256 100465152 1 - by flanking markers 4 104614665 104653122 1 - by flanking markers RRID:RRRC_00423 2290057 F344-TgTn(T2/Bart3)1Ceb The Sleeping Beauty transposon construct, T2/Bart3 consists of inverted terminal repeats separated by a gene trap cassette. The gene trap cassette consists of two splice acceptors, one from adenovirus and one from the mouse Hox9a gene, situated in opposite orientations. Each splice acceptor is followed by stop codons in each reading frame and a polyadenylation signal. Furthermore, the T2/Bart3 transposon harbors a mouse tyrosinase minigene which rescues the phenotype of albino rats, but demonstrates position effect variegated expression. PGA transgenic Cryopreserved Sperm RRID:RGD_2290057 2290064 F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Trpc4 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Trpc4Tn(sb-T2/Bart3)2.192Mcwi 2290060 2 143350286 143485716 1 - by flanking markers 2 163115873 163282223 1 - by flanking markers 2 143433102 143605757 1 - by flanking markers 2 138307676 138476856 1 - by flanking markers RRID:RRRC_00344 2290065 F344-CA338503Tn(sb-T2/Bart3)2.196Mcwi this Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD: 2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). PGA mutant Unknown CA338503Tn(sb-T2/Bart3)2.196Mcwi 2290059 RRID:RGD_2290065 2290066 F344-Nell1Tn(sb-T2/Bart3)2.195Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the second intron of the Nell1. PGA mutant Unknown Nell1Tn(sb-T2/Bart3)2.195Mcwi 2290061 1 99805922 100758002 1 - by flanking markers 1 106397933 107260905 1 - by flanking markers 1 105348577 106218970 1 - by flanking markers 1 99709305 100573872 1 - by flanking markers RRID:RGD_2290066 2290067 F344-BI285226Tn(sb-T2/Bart3)2.193Mcwi this Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). PGA mutant Unknown BI285226Tn(sb-T2/Bart3)2.193Mcwi 2290062 RRID:RGD_2290067 2290078 F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 8th intron of the Myo9a gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Myo9aTn(sb-T2/Bart3)2.186Mcwi 2290068 8 63578001 63783813 1 - by flanking markers 8 64335907 64534890 1 - by flanking markers 8 64573248 64777607 1 - by flanking markers 8 60149234 60348726 1 - by flanking markers RRID:RRRC_00385 2290079 F344-BI285226Tn(sb-T2/Bart3)2.194Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PGA mutant Unknown BI285226Tn(sb-T2/Bart3)2.194Mcwi 2290069 RRID:RGD_2290079 2290080 F344-BI284938Tn(sb-T2/Bart3)2.187Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PGA mutant Unknown BI284938Tn(sb-T2/Bart3)2.187Mcwi 2290074 RRID:RGD_2290080 2290081 F344-BI284934Tn(sb-T2/Bart3)2.185Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PGA, Rat Resource & Research Center mutant Cryopreserved Sperm BI284934Tn(sb-T2/Bart3)2.185Mcwi 2290072 RRID:RRRC_00367 2290082 F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 7th intron of the Brinp3 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Brinp3Tn(sb-T2/Bart3)2.189Mcwi 2290071 13 60584348 61024196 1 - by flanking markers 13 68507826 68938032 1 - by flanking markers 13 63526486 63959390 1 - by flanking markers 13 58413883 58846828 1 - by flanking markers RRID:RRRC_00425 2290083 F344-Slc24a3Tn(sb-T2/Bart3)2.188Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 3rd intron of the Slc24a3 gene. PGA mutant Unknown Slc24a3Tn(sb-T2/Bart3)2.188Mcwi 2290073 3 133734890 134249326 1 - by flanking markers 3 145760074 146259491 1 - by flanking markers 3 139333942 139835728 1 - by flanking markers 3 132552119 133051192 1 - by flanking markers RRID:RGD_2290083 2290100 F344-Entpd6Tn(sb-T2/Bart3)2.174Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Entpd6 gene. PGA mutant Unknown Entpd6Tn(sb-T2/Bart3)2.174Mcwi 2290086 3 141385480 141407860 1 - by flanking markers 3 152905464 152927857 1 - by flanking markers 3 146546424 146568828 1 - by flanking markers 3 139575659 139598163 1 - by flanking markers RRID:RGD_2290100 2290101 F344-CB706876Tn(sb-T2/Bart3)2.181Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PGA mutant Unknown CB706876Tn(sb-T2/Bart3)2.181Mcwi 2290092 RRID:RGD_2290101 2290102 F344-Klhl13Tn(sb-T2/Bart3)2.176Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Klhl13 gene. PGA mutant Unknown Klhl13Tn(sb-T2/Bart3)2.176Mcwi 2290085 X 10344050 10424665 1 - by flanking markers X 121716856 121876640 1 - by flanking markers X 121578965 121735014 1 - by flanking markers X 113942309 114107355 1 - by flanking markers RRID:RGD_2290102 2290103 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi this Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb and F344-Tg(PGK2-sb11)Ceb. This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Nrg1 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Nrg1Tn(sb-T2/Bart3)2.183Mcwi 2290090 16 63937796 64126183 1 - by flanking markers 16 62632432 63718738 1 - by flanking markers 16 62969573 64065063 1 - by flanking markers 16 59250658 60303024 1 - by flanking markers RRID:RRRC_00343 2290104 F344-Cadm2Tn(sb-T2/Bart3)2.180Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the Cadm2 gene. PGA mutant Unknown Cadm2Tn(sb-T2/Bart3)2.180Mcwi 2290088 11 4273771 5330393 1 - by flanking markers 11 7871257 8090100 1 - by flanking markers 11 4175078 4397335 1 - by flanking markers 11 4548367 5525420 1 - by flanking markers RRID:RGD_2290104 2290105 F344-Sptbn4Tn(sb-T2/Bart3)2.179Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 17th intron of the Sptbn4 gene. PGA mutant Unknown Sptbn4Tn(sb-T2/Bart3)2.179Mcwi 2290097 1 82436626 82523827 1 - by flanking markers 1 85379609 85467354 1 - by flanking markers 1 84168494 84254679 1 - by flanking markers 1 82650750 82738345 1 - by flanking markers RRID:RGD_2290105 2290106 F344-BQ195794Tn(sb-T2/Bart3)2.182Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PGA mutant Unknown BQ195794Tn(sb-T2/Bart3)2.182Mcwi 2290070 RRID:RGD_2290106 2290107 F344-CyssTn(sb-T2/Bart3)2.173Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Cyss gene. PGA mutant Unknown CyssTn(sb-T2/Bart3)2.173Mcwi 2290095 3 138826625 138830963 1 - by flanking markers 3 150801395 150805733 1 - by flanking markers 3 144427430 144431768 1 - by flanking markers 3 137432272 137436610 1 - by flanking markers RRID:RGD_2290107 2290108 F344-LOC290071Tn(sb-T2/Bart3)2.170Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the LOC290071 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) LOC290071Tn(sb-T2/Bart3)2.170Mcwi 2290089 15 30634899 32273880 1 - by flanking markers RRID:RRRC_00338 2290109 F344-CA338503Tn(sb-T2/Bart3)2.168Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PGA mutant Unknown CA338503Tn(sb-T2/Bart3)2.168Mcwi 2290087 RRID:RGD_2290109 2290110 F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the Lims1 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Lims1Tn(sb-T2/Bart3)2.169Mcwi 2290096 20 37349188 37397427 1 - by flanking markers 20 29715580 29824252 1 - by flanking markers 20 27895981 28004767 1 - by flanking markers 20 26309833 26418511 1 - by flanking markers RRID:RRRC_00362 2290111 F344-Cst3Tn(sb-T2/Bart3)2.172Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Cst3 gene. PGA mutant Unknown Cst3Tn(sb-T2/Bart3)2.172Mcwi 2290093 3 137650903 137654776 1 - by flanking markers 3 149628692 149632565 1 - by flanking markers 3 143219671 143223544 1 - by flanking markers 3 136336923 136340796 1 - by flanking markers RRID:RGD_2290111 2290112 F344-CA338503Tn(sb-T2/Bart3)2.175Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PGA mutant Unknown CA338503Tn(sb-T2/Bart3)2.175Mcwi 2290094 RRID:RGD_2290112 2290113 F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the Fam19a2 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Fam19a2Tn(sb-T2/Bart3)2.184Mcwi 2290098 7 63388665 63566226 1 - by flanking markers 7 66221368 66695803 1 - by flanking markers 7 66017066 66496690 1 - by flanking markers 7 58942598 59418640 1 - by flanking markers RRID:RRRC_00387 2290114 F344-Slc24a3Tn(sb-T2/Bart3)2.178Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Slc24a3 gene. PGA mutant Unknown Slc24a3Tn(sb-T2/Bart3)2.178Mcwi 2290091 3 133734890 134249326 1 - by flanking markers 3 145760074 146259491 1 - by flanking markers 3 139333942 139835728 1 - by flanking markers 3 132552119 133051192 1 - by flanking markers RRID:RGD_2290114 2290135 F344-Chsy1Tn(sb-T2/Bart3)2.165Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Chsy1. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Chsy1Tn(sb-T2/Bart3)2.165Mcwi 2290123 1 120539002 120600102 1 - by flanking markers 1 128095353 128156041 1 - by flanking markers 1 127010587 127071570 1 - by flanking markers 1 119689626 119750711 1 - by flanking markers RRID:RRRC_00337 2290136 F344-Slc24a4Tn(sb-T2/Bart3)2.145Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Slc24a4 gene. PGA mutant Unknown Slc24a4Tn(sb-T2/Bart3)2.145Mcwi 2290127 6 126403837 126538501 1 - by flanking markers 6 135226112 135364945 1 - by flanking markers 6 126015799 126158727 1 - by flanking markers 6 121278746 121419811 1 - by flanking markers RRID:RGD_2290136 2290137 F344-BF522453Tn(sb-T2/Bart3)2.166Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PGA, Rat Resource & Research Center mutant Cryopreserved Sperm BF522453Tn(sb-T2/Bart3)2.166Mcwi 2290126 RRID:RRRC_00361 2290138 F344-Glis1Tn(sb-T2/Bart3)2.149Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the Glis1 gene. PGA mutant Extinct (as of 2016-12-12) Glis1Tn(sb-T2/Bart3)2.149Mcwi 2290128 5 128736183 128739369 1 - by flanking markers 5 130891667 131081696 1 - by flanking markers 5 127043344 127233395 1 - by flanking markers 5 122222155 122412141 1 - by flanking markers RRID:RRRC_00332 2290139 F344-AW527406Tn(sb-T2/Bart3)2.156Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PGA mutant Unknown AW527406Tn(sb-T2/Bart3)2.156Mcwi 2290122 RRID:RGD_2290139 2290140 F344-BI285110Tn(sb-T2/Bart3)2.167Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PGA mutant Unknown BI285110Tn(sb-T2/Bart3)2.167Mcwi 2290115 RRID:RGD_2290140 2290141 F344-AbatTn(sb-T2/Bart3)2.163Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Abat gene. PGA, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2016-11-11) AbatTn(sb-T2/Bart3)2.163Mcwi 2290121 10 7040725 7137154 1 - by flanking markers 10 5894187 6002068 1 - by flanking markers 10 7093406 7200439 1 - by flanking markers 10 6996688 7092835 1 - by flanking markers RRID:RRRC_00381 2290142 F344-LOC681893Tn(sb-T2/Bart3)2.161Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the LOC681893 gene. PGA mutant Unknown LOC681893Tn(sb-T2/Bart3)2.161Mcwi 2290118 RRID:RGD_2290142 2290143 F344-NapbTn(sb-T2/Bart3)2.162Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the Napb gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) NapbTn(sb-T2/Bart3)2.162Mcwi 2290116 3 137447072 137490500 1 - by flanking markers 3 149431212 149473190 1 - by flanking markers 3 143017571 143063904 1 - by flanking markers 3 136132248 136179225 1 - by flanking markers RRID:RRRC_00335 2290144 F344-Adgrl3Tn(sb-T2/Bart3)2.151Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 7th intron of the Adgrl3 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-13) Adgrl3Tn(sb-T2/Bart3)2.151Mcwi 2290129 14 28385112 28854677 1 - by flanking markers 14 28183727 29040121 1 - by flanking markers 14 28362176 29226085 1 - by flanking markers 14 26336320 27104060 1 - by flanking markers RRID:RRRC_00334 2290145 F344-BI284938Tn(sb-T2/Bart3)2.155Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PGA mutant Unknown BI284938Tn(sb-T2/Bart3)2.155Mcwi 2290120 RRID:RGD_2290145 2290146 F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Plce1 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Plce1Tn(sb-T2/Bart3)2.146Mcwi 2290125 1 242794858 243103437 1 - by flanking markers 1 264652842 264956664 1 - by flanking markers 1 257156023 257465440 1 - by flanking markers 1 236243445 236552571 1 - by flanking markers RRID:RRRC_00380 2290147 F344-Sptlc3Tn(sb-T2/Bart3)2.147Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 6th intron of the Sptlc3 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Sptlc3Tn(sb-T2/Bart3)2.147Mcwi 2290124 3 127691668 127825206 1 - by flanking markers 3 139023075 139151792 1 - by flanking markers 3 132560437 132689313 1 - by flanking markers 3 126847878 126978010 1 - by flanking markers RRID:RRRC_00331 2290148 F344-Map2k5Tn(sb-T2/Bart3)2.150Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 17th intron of the Map2k5 gene. PGA mutant Extinct (as of 2016-12-21) Map2k5Tn(sb-T2/Bart3)2.150Mcwi 2290117 8 67313472 67542723 1 - by flanking markers 8 67784868 68010809 1 - by flanking markers 8 68055976 68282656 1 - by flanking markers 8 63625220 63852090 1 - by flanking markers RRID:RRRC_00333 2290159 F344-Spetex-2HTn(sb-T2/Bart3)2.136Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Spetex-2H gene. PGA mutant Unknown Spetex-2HTn(sb-T2/Bart3)2.136Mcwi 2290150 15 5180002 5186910 1 - by flanking markers RRID:RGD_2290159 2290160 F344-Rph3aTn(sb-T2/Bart3)2.104Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 15th intron of the Rph3a gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Rph3aTn(sb-T2/Bart3)2.104Mcwi 2290154 12 36678613 36753316 1 - by flanking markers 12 42938832 43014142 1 - by flanking markers 12 41073296 41149799 1 - by flanking markers 12 35542389 35618901 1 - by flanking markers RRID:RRRC_00326 2290161 F344-Tmco1Tn(sb-T2/Bart3)2.135Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 6th intron of the Tmco1 gene. PGA mutant Extinct (as of 2017-01-30) Tmco1Tn(sb-T2/Bart3)2.135Mcwi 2290156 13 82971926 82995262 1 - by flanking markers 13 90108152 90202246 1 - by flanking markers 13 85465015 85559113 1 - by flanking markers 13 79460229 79483557 1 - by flanking markers RRID:RRRC_00328 2290162 F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Inpp4b gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Inpp4bTn(sb-T2/Bart3)2.143Mcwi 2290149 19 27722430 28363639 1 - by flanking markers 19 40508684 41132035 1 - by flanking markers 19 29592889 30341528 1 - by flanking markers 19 25920189 26670085 1 - by flanking markers RRID:RRRC_00379 2290163 F344-TgTn(T2/Bart3)2Ceb transposon sleeping beauty The Sleeping Beauty transposon construct, T2/Bart3 consists of inverted terminal repeats separated by a gene trap cassette. The gene trap cassette consists of two splice acceptors, one from Adenovirus and one from the mouse Hox9a gene, situated in opposite orientations. Each splice acceptor is followed by stop codons in each reading frame and a polyadenylation signal. Furthermore, the T2/Bart3 transposon harbors a mouse tyrosinase minigene which rescues the phenotype of albino rats, but demonstrates position effect variegated expression. PGA transgenic Extinct (as of 2016-11-14) RRID:RGD_2290163 2290164 F344-Syne1Tn(sb-T2/Bart3)2.68Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 109th intron of the Syne1 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Syne1Tn(sb-T2/Bart3)2.68Mcwi 2290153 1 35803552 36269628 1 - by flanking markers 1 42947742 43158478 1 - by flanking markers 1 41608287 42086662 1 - by flanking markers 1 41512146 41983382 1 - by flanking markers RRID:RRRC_00325 2290165 F344-NtmTn(sb-T2/Bart3)2.130Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 3th intron of the Ntm gene. PGA mutant Extinct (as of 2017-01-24) NtmTn(sb-T2/Bart3)2.130Mcwi 2290157 8 28587019 29019888 1 - by flanking markers 8 30073163 31070882 1 - by flanking markers 8 30039332 31041755 1 - by flanking markers 8 27376582 28366604 1 - by flanking markers RRID:RRRC_00327 2290166 F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 18th exon of the Plcb3 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Plcb3Tn(sb-T2/Bart3)2.69Mcwi 2290155 1 209628425 209643694 1 - by flanking markers 1 229198739 229215831 1 - by flanking markers 1 222207887 222224993 1 - by flanking markers 1 204143257 204160384 1 - by flanking markers RRID:RRRC_00424 2290167 F344-Dlg1Tn(sb-T2/Bart3)2.133Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 6th intron of the Dlg1 gene. PGA mutant Unknown Dlg1Tn(sb-T2/Bart3)2.133Mcwi 2290152 11 70735283 70930374 1 - by flanking markers 11 75239783 75454358 1 - by flanking markers 11 72164566 72378895 1 - by flanking markers 11 68911883 69103230 1 - by flanking markers RRID:RGD_2290167 2290168 F344-Pde5aTn(sb-T2/Bart3)2.144Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). The trap construct targeted to the 4th intron of the Pde5a gene. PGA mutant Extinct (as of 2017-01-24) Pde5aTn(sb-T2/Bart3)2.144Mcwi 2290151 2 219410394 219550910 1 - by flanking markers 2 246260843 246406296 1 - by flanking markers 2 226899604 227044916 1 - by flanking markers 2 210858515 211003480 1 - by flanking markers RRID:RRRC_00330 2290169 F344-Tg(PGK2-sb11)Ceb Sleeping beauty transposase transgenic sb11 cDNA linked to human PGK2 promoter was used. PGA transgenic Extinct (as of 2016-11-14) RRID:RGD_2290169 2290170 F344-Cd226Tn(sb-T2/Bart3)2.141Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 3rd intron of the Cd226 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Cd226Tn(sb-T2/Bart3)2.141Mcwi 2290158 18 86064574 86157909 1 - by flanking markers 18 85337942 85433295 1 - by flanking markers 18 86299392 86394772 1 - by flanking markers 18 82449924 82545107 1 - by flanking markers RRID:RRRC_00329 2290171 F344-LOC681893Tn(sb-T2/Bart3)2.159Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the LOC681893 gene. PGA mutant Unknown LOC681893Tn(sb-T2/Bart3)2.159Mcwi 2290119 RRID:RGD_2290171 2290186 SD-Tg(SOD1*G93A)39 SD rats were microinjected with a linear 11.5 kb EcoRI-BamH1 fragment containing the coding sequence and promoter region of human SOD1 gene with G93A mutation Department of Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan transgenic Unknown SOD1 730855 RRID:RGD_2290186 2290187 SD-Tg(SOD1*H46R)4 SD rats were microinjected with a linear NdeI-Xba1 fragment containing the coding sequence and promoter region of human SOD1 gene with H46R mutation Department of Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan transgenic Unknown SOD1 730855 RRID:RGD_2290187 2290272 SS/JrNgs strain from Disease Model Cooperative Research Association Kyoto, Japan now maintained at Nagasaki University School of Medicine, Nagasaki Japan National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension RRID:RGD_2290272 2290273 SHRSP.WKY-(D1Mgh5-D1Wox10)(D9Rat83-D9Mit6)/IzmTkyo The desired fragment is transferred from WKY to SHRSP National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension RRID:RGD_2290273 2290274 SHRSP.WKY-(D15Rat2-D15Rat94)/Tkyo This congenic strain was established from WKY purchased from Japan SLC, Inc. and SHRSP at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 15 11832728 76115762 1 - by flanking markers 15 15643978 80627247 1 - by flanking markers 15 11605245 77072316 1 - by flanking markers 15 10355054 69625966 1 - by flanking markers RRID:RGD_2290274 2290275 SHRSP.WKY-(D3Tkyo7-D3Rat1)/Tkyo The desired fragment is transferred from WKY to SHRSP National Bio Resource Project Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 3 170016252 170016653 1 - by flanking markers 3 180127863 180128021 1 - by flanking markers 3 176417943 176418101 1 - by flanking markers 3 168026691 168026850 1 - by flanking markers RRID:RGD_2290275 2290276 SHRSP.WKY-(D3Mgh16-D3Mgh15)/Tkyo This congenic strain was established from WKY purchased from Japan SLC, Inc. and SHRSP at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 3 6373335 118757096 1 - by flanking markers 3 11361699 130099054 1 - by flanking markers 3 6000748 123599709 1 - by flanking markers 3 10778704 118275626 1 - by flanking markers RRID:RGD_2290276 2290277 SHRSP.WKY-(D3Rat227-D3Rat166)/Tkyo The desired fragment is transferred from WKY to SHRSP National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 3 41054012 101359980 1 - by flanking markers 3 50522686 113470358 1 - by flanking markers 3 45406058 106900596 1 - by flanking markers 3 43827364 102200699 1 - by flanking markers RRID:RGD_2290277 2290278 SR/JrNgs strain from Disease Model Cooperative Research Association Kyoto, Japan now maintained at Nagasaki University School of Medicine, Nagasaki Japan National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension RRID:RGD_2290278 2290279 SHRSP.WKY-(D15Rat68-D15Rat106)/Tkyo This congenic strain was established from WKY purchased from Japan SLC, Inc. and SHRSP at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 15 62521452 106177917 1 - by flanking markers 15 67139660 109944957 1 - by flanking markers 15 63498932 106550657 1 - by flanking markers 15 56484420 98288169 1 - by flanking markers RRID:RGD_2290279 2290280 SHRSP.WKY-(D3Mgh16-D3Rat110)/Tkyo The desired fragment is transferred from WKY to SHRSP National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 3 6373335 42729760 1 - by flanking markers 3 11361699 53824856 1 - by flanking markers 3 6000748 47155284 1 - by flanking markers 3 10778704 10778823 1 - by flanking markers RRID:RGD_2290280 2290281 SHRSP.WKY-(D3Rat227-D3Rat1)/Tkyo This congenic strain was established from WKY purchased from Japan SLC, Inc. and SHRSP at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 3 41054012 170016653 1 - by flanking markers 3 50522686 180128021 1 - by flanking markers 3 45406058 176418101 1 - by flanking markers 3 43827364 168026850 1 - by flanking markers RRID:RGD_2290281 2290282 SHRSP.WKY-(D1Mgh5-D1Rat71)(D13Tkyo1-D13Rat51)/IzmTkyo The desired fragment is transferred from WKY to SHRSP National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension RRID:RGD_2290282 2290298 SHR-Tg(Thy1-MAPT)318 SHR embryos were microinjected with mouse Thy1 promoter and cDNA coding for human tau protein truncated at amino acid positions 151-391 Axon-Neuroscience GmbH, Vienna, Austria transgenic Unknown MAPT 736496 RRID:RGD_2290298 2290299 SHR-Tg(Thy1-MAPT)72 SHR embryos were microinjected with mouse Thy1 promoter and cDNA coding for human tau protein truncated at amino acid positions 151-391 Axon-Neuroscience GmbH, Vienna, Austria transgenic Unknown MAPT 736496 RRID:RGD_2290299 2290311 SD-Tg(SOD1*G93A)26Dwc SD rats were microinjected with a linear 12 kb EcoRI-BamH1 fragment containing the coding sequence and promoter region of human SOD1 gene with G93A mutation Ludwig Institute of Cancer Research, University of California at San Diego, La Jolla, California transgenic Unknown SOD1 730855 RRID:RGD_2290311 2290386 SD-Tg(Wlds)23Cole SD rats were microinjected with a mouse Wlds with a Ube4b-derived domain with A46R and M60T amino acid changes University of Cologne, Cologne, Germany transgenic Unknown RRID:RGD_2290386 2290387 SD-Tg(UbC-APPswe)6590 SD embryos were microinjected with a DNA construct containing a UbC promoter and human APPswe gene containing the Swedish APP670/671 mutation Karolinska Institutet, Stockholm, Sweden transgenic Unknown APP 736021 RRID:RGD_2290387 2290391 SD-Tg(Wlds)79Cole SD rats were microinjected with a mouse Wlds with a Ube4b-derived domain with A46R and M60T amino acid changes University of Cologne, Cologne, Germany transgenic Unknown RRID:RGD_2290391 2290429 SS-Tg(ApoC3-CETP)53Opaz SS/JrHsd embryos were microinjected with 1.57 kb human CETP cDNA construct into pSV-SPORT1 with human ApoC3 promoter Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00310 2291840 F344-Dzank1Tn(sb-T2/Bart3)2.164Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the Dzank1 gene. PGA mutant Extinct (as of 2016-10-17) Dzank1Tn(sb-T2/Bart3)2.164Mcwi 2291839 3 133021912 133073987 1 - by flanking markers 3 145054445 145114445 1 - by flanking markers 3 138624517 138684530 1 - by flanking markers 3 131855890 131908217 1 - by flanking markers RRID:RGD_2291840 2292168 ISIAH Inherited stress-induced arterial hypertension Selected from an outbred population of Wistar rats at the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia, for increased response of blood pressure (systolic) which was induced by restraining the animals in a cylindrical wire mess that caused a mild emotional stress Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia inbred Unknown RRID:RGD_2292168 2292384 SS.LEW-(D10Chm167-D10Chm257)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Chm128-D10Chm182)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 70589279 71366998 1 - by flanking markers 10 69375493 71016171 1 - by flanking markers 10 69742043 70500971 1 - by flanking markers 10 67335465 68083956 1 - by flanking markers RRID:RGD_2292384 2292385 SS.LEW-(D10Mco30-D10Got107)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Rat27-Igfbp4)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 77547289 78712717 1 - by flanking markers 10 73693979 77664589 1 - by flanking markers 10 76420583 77803328 1 - by flanking markers 10 73887148 75121215 1 - by flanking markers RRID:RGD_2292385 2292386 SS.LEW-(D10Chm155-D10Rat127)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Rat27-Igfbp4)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 87272312 100040883 1 - by flanking markers 10 86214887 98591695 1 - by flanking markers 10 86418952 98888676 1 - by flanking markers 10 83463114 95552352 1 - by flanking markers RRID:RGD_2292386 2292387 SS.LEW-(D10Chm224-D10Chm259)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Chm224-D10Chm6)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 74705355 75291923 1 - by flanking markers 10 75776633 76309841 1 - by flanking markers 10 74325927 74326153 1 - by flanking markers 10 71831756 71831983 1 - by flanking markers RRID:RGD_2292387 2292388 SS.LEW-(D10Chm246-D10Chm257)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Chm128-D10Chm182)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 71262405 71366998 1 - by flanking markers 10 70027256 71016171 1 - by flanking markers 10 70396378 70500971 1 - by flanking markers 10 67979320 68083956 1 - by flanking markers RRID:RGD_2292388 2292389 SS.LEW-(D10Chm10-D10Chm14)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Rat13-D10Rat11)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 96778676 99233951 1 - by flanking markers 10 95351725 97793613 1 - by flanking markers 10 95617075 98079438 1 - by flanking markers 10 92348201 94759977 1 - by flanking markers RRID:RGD_2292389 2292390 SS.LEW-(D10Rat194-D10Chm243)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Chm224-D10Chm6)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 75706467 76081753 1 - by flanking markers 10 75018615 75388855 1 - by flanking markers 10 74712046 75083773 1 - by flanking markers 10 72219294 72590339 1 - by flanking markers RRID:RGD_2292390 2292451 F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the Stxbp5l gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Stxbp5lTn(sb-T2/Bart3)2.202Mcwi 2292450 11 65129572 65455115 1 - by flanking markers 11 69337663 69661463 1 - by flanking markers 11 66246624 66566331 1 - by flanking markers 11 63334667 63654270 1 - by flanking markers RRID:RRRC_00386 2292452 F344-Syndig1Tn(sb-T2/Bart3)2.171Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the Syndig1 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Syndig1Tn(sb-T2/Bart3)2.171Mcwi 2292449 3 139434170 139834916 1 - by flanking markers 3 151405855 151571801 1 - by flanking markers 3 145031427 145199273 1 - by flanking markers 3 138030995 138234646 1 - by flanking markers RRID:RRRC_00342 2292453 F344-BE329202Tn(sb-T2/Bart3)2.198Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm BE329202Tn(sb-T2/Bart3)2.198Mcwi 2292448 RRID:RRRC_00345 2292454 F344-RGD1564304Tn(sb-T2/Bart3)2.201Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the RGD1564304 gene. PhysGen mutant Extinct (as of 2017-01-26) RGD1564304Tn(sb-T2/Bart3)2.201Mcwi 2292447 RRID:RGD_2292454 2292459 WF.LEW-RVFV This rat strain was developed by classical breeding technique inserting the gene for resistance to lethal RVFV infection from the LEW rat strain into the genetic background of the WF rat strain. Rat Resource and Research Center congenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-11-15) RRID:RRRC_00208 2292526 SS-Tg(Atp1a1)48Opaz SS/Jr rats were microinjected with rat alpha1 Na,K-ATPase promoter (-1288) 5 flanking regulatory region isolated from Sprague Dawley genomic library); transgene cDNA: Dahl R alpha1 Na,K-ATPase Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-05-24) RRID:RRRC_00281 2292527 SS-Tg(RA1V9)64Opaz Dahl Sensitive rats were microinjected with AngII/AVP receptor gene and SV40 PolyA signal. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00308 2292528 F344-Tg(APPswe)Opaz F344 embryos were microinjected with a DNA construct containing human amyloid precursor protein with Swedish variant (APPswe; K670N/M671L) under control of platelet-derived growth factor-B (PDGF-b promoter) as a promoter Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00283 2292529 LEW-Tg((ROSA)26Sor-luc)11Jmsk LEW/Crlj were microinjected with luciferase cDNA with ROSA26 promoter in the NcoI and XbaI site Rat Resource and Research Center, National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2017-08-08) Development RRID:RRRC_00299 2292530 SD-Tg(Pou5f1-Dsred) This transgenic strain carries a random insertion of a construct containing mouse Oct 4 promoter and DsRed. This results in DsRed expression in germ and early embryonic cells. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00320 2292531 SD-Tg(Pou5f1-EGFP) This transgenic strain carries a random insertion of a construct containing mouse promoter Pou5f1 to drive the expression of EGFP. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-04-23) RRID:RRRC_00319 2292532 F344-Tg(betaCTF-l45F) F344 embryos were microinjected with human beta-C-terminal fragment of the amyloid protein Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00277 2292564 ACI.COP-(D6Rat80-D6Rat146)/Shul Female COP/CrCrl and male ACI/SegHsd were crossed to get F1 progeny which were in turn backcrossed with female ACI/SegHsd; the offsprings were genotyped Department of Genetics, Cell Biology and Anatomy, University Of Nebraska Medical Center, Omaha, Nebraska congenic Unknown 6 16302145 16302283 1 - by flanking markers 6 26052697 26052834 1 - by flanking markers 6 16100120 16100257 1 - by flanking markers 6 2299357 2299495 1 - by flanking markers RRID:RGD_2292564 2292565 ACI.COP-(D3Mgh16-D3Rat119)/Shul Female COP/CrCrl and male ACI/SegHsd were crossed to get F1 progeny which were in turn backcrossed with female ACI/SegHsd; the offsprings were genotyped Department of Genetics, Cell Biology and Anatomy, University Of Nebraska Medical Center, Omaha, Nebraska congenic Unknown 3 6373335 52643538 1 - by flanking markers 3 11361699 63334520 1 - by flanking markers 3 6000748 56715367 1 - by flanking markers 3 10778704 55223816 1 - by flanking markers RRID:RGD_2292565 2292566 ACI.COP-(D3Rat130-D3Rat114)/Shul Female COP/CrCrl and male ACI/SegHsd were crossed to get F1 progeny which were in turn backcrossed with female ACI/SegHsd; the offsprings were genotyped Department of Genetics, Cell Biology and Anatomy, University Of Nebraska Medical Center, Omaha, Nebraska congenic Unknown 3 44551252 149496698 1 - by flanking markers 3 55227530 160347840 1 - by flanking markers 3 48561928 155263151 1 - by flanking markers 3 47233211 147415807 1 - by flanking markers RRID:RGD_2292566 2292567 ACI.COP-(D10Mgh20-D10Rat4)/Shul Female COP/CrCrl and male ACI/SegHsd were crossed to get F1 progeny which were in turn backcrossed with female ACI/SegHsd; the offsprings were genotyped Department of Genetics, Cell Biology and Anatomy, University Of Nebraska Medical Center, Omaha, Nebraska congenic Unknown 10 53781126 107033716 1 - by flanking markers 10 53376677 105533612 1 - by flanking markers 10 105875105 105875260 1 - by flanking markers 10 102134116 102134272 1 - by flanking markers RRID:RGD_2292567 2292647 SS.LEW-(D1Mco36-D1Rat106)/Mco This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Rat49)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 122991895 139471673 1 - by flanking markers 1 130267716 146282094 1 - by flanking markers 1 129208943 145354344 1 - by flanking markers 1 121833674 137184926 1 - by flanking markers RRID:RGD_2292647 2292648 SS.LEW-(D1Mco36-D1Mco77)/Mco This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Rat49)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 122991895 122992360 1 - by flanking markers 1 130267716 130268180 1 - by flanking markers 1 129208943 129209407 1 - by flanking markers 1 121833674 121834139 1 - by flanking markers RRID:RGD_2292648 2292649 SS.LEW-(D1Mco36-D1Rat131)/1Mco This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Rat49)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 122991895 145648920 1 - by flanking markers 1 130267716 159182239 1 - by flanking markers 1 129208943 152871103 1 - by flanking markers 1 121833674 142990467 1 - by flanking markers RRID:RGD_2292649 2292650 SS.LEW-(D1Mco36-D1Rat131)/2Mco This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Rat49)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 122991895 145648920 1 - by flanking markers 1 130267716 159182239 1 - by flanking markers 1 129208943 152871103 1 - by flanking markers 1 121833674 142990467 1 - by flanking markers RRID:RGD_2292650 2292651 SS.LEW-(D1Mco99-D1Rat49)/Mco This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Rat49)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 157497884 157498254 1 - by flanking markers 1 171330622 171330794 1 - by flanking markers 1 165129767 165129939 1 - by flanking markers 1 154464069 154464242 1 - by flanking markers RRID:RGD_2292651 2292652 SS.LEW-(D1Mco85-D1Rat49)/Mco This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Rat49)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 157497884 157498254 1 - by flanking markers 1 171330622 171330794 1 - by flanking markers 1 165129767 165129939 1 - by flanking markers 1 154464069 154464242 1 - by flanking markers RRID:RGD_2292652 2292653 SS.LEW-(D1Mco36-D1Mco101)/Mco This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Rat49)/Jr to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 97174943 122992360 1 - by flanking markers 1 103735751 130268180 1 - by flanking markers 1 102658741 129209407 1 - by flanking markers 1 97146283 121834139 1 - by flanking markers RRID:RGD_2292653 2293012 ACI.BBDP-(RT1u)(Gimap5)/Sunn 2 BBDP regions (Iddm1 and Iddm2) were introgressed into the ACI/SegHsd background Sunnybrook Research Institute, Toronto, Ontario, Canada, Rat Resource and Research Center congenic Unknown RRID:RRRC_00788 2293120 LOU.BN-(D10Mgh1-D10Mgh14)/Ins segment of chr 10 from BN which contained the Ace gene was introgressed into the genetic background of LOU Cardiovascular Physiopathology, INSERM, Montpellier, France congenic Unknown Ace 2493 10 65379850 65379965 1 - by flanking markers 10 65109232 65109346 1 - by flanking markers 10 66539729 66539843 1 - by flanking markers 10 64155469 64155584 1 - by flanking markers RRID:RGD_2293120 2293143 SS.BN-(D13Rat20-D13Rat127)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown Ren 3554 13 38329089 55373537 1 - by flanking markers 13 23200281 47267192 1 - by flanking markers 13 17996178 42155682 1 - by flanking markers 13 37262092 53383120 1 - by flanking markers RRID:RGD_2293143 2293144 SS.BN-(D13Rat91-D13Rat179)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 46911975 60669696 1 - by flanking markers 13 55853015 68592209 1 - by flanking markers 13 50799478 63611529 1 - by flanking markers 13 45417753 58498119 1 - by flanking markers RRID:RGD_2293144 2293145 SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi SS/JrHsdMcwi were crossed with SS-Chr 13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown Ren 3554 13;13;13 49428397;48990782;45215472 49428577;48990782;45215667 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 13;13 58314588;54170894 58314767;54171089 1 - by flanking markers;1 - by flanking markers 13;13 49102205;53264698 49102400;53264877 1 - by flanking markers;1 - by flanking markers 13;13 43763752;47841075 43763948;47841255 1 - by flanking markers;1 - by flanking markers RRID:RGD_2293145 2293146 SS.BN-(D13Rat20-D13Got22)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13;5 38329089;97701780 45828716;97703112 1 - by flanking markers;1 - by flanking markers 13;5 47267053;100631702 54791605;100633034 1 - by flanking markers;1 - by flanking markers 13;5 42155543;96601805 49720682;96603137 1 - by flanking markers;1 - by flanking markers 13;5 37262092;93541170 37262232;93542503 1 - by flanking markers;1 - by flanking markers RRID:RGD_2293146 2293354 LEW.WKY-(D16Rat88-D16Rat40)/Tja segment of interest of chr 16 from WKY/NCrl was introgressed into LEW/SsNHsd Imperial College, London, UK. Rat Resource and Research Center congenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26) 16 819225 60432230 1 - by flanking markers 16 1534408 59992088 1 - by flanking markers 16 1550187 60316851 1 - by flanking markers 16 832236 56733837 1 - by flanking markers RRID:RRRC_00708 2293355 WKY.LEW-(D16Rat88-D16Rat40)/Tja 22.6 cM segment of chr 16 from LEW/SsNHsd was introgressed into WKY/NCrl Imperial College, London, UK congenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26) 16 819225 60432230 1 - by flanking markers 16 1534408 59992088 1 - by flanking markers 16 1550187 60316851 1 - by flanking markers 16 832236 56733837 1 - by flanking markers RRID:RGD_2293355 2293729 SHR-Gja8m1-/-Cub This strain is derived from SHR/OlaIpcv where a mutation is observed in the NH2-terminal cytosolic domain of Cx50, L7Q Department of Biology, Charles University in Prague, Prague, Czech Republic coisogenic Unknown Gja8m1Cub 12791992 RRID:RGD_2293729 2293761 LH-Chr 17BN/Mav Chr 17 from BN/NHsdMcwi was introgressed onto the genetic background of LH/Mav and then genotyped Laboratoire de Physiologie, Lyon Cedex , France consomic Unknown RRID:RGD_2293761 2293770 SHHF/Bbb Initial breeders were from the original colony of S.A. McCune, University of Colorado, Boulder. These are maintained under strict breeding Max-Delbruck-Center for Molecular Medicine, Berlin, Germany inbred Unknown RRID:RGD_2293770 2293832 LOU.BN-(D6Rat128-D6Rat115)/Ins segment of interest from chr 6 of BN/Rj was introgressed on LOU/Ins by performing 8 backcrosses followed by 1 intercross INSERM, Paris, France congenic Unknown 6 76613351 116550459 1 - by flanking markers 6 86645162 125802733 1 - by flanking markers 6 77111071 116576287 1 - by flanking markers 6 73691999 111838254 1 - by flanking markers RRID:RGD_2293832 2298494 Kini:DA,PVG-G10 Two breeding pairs from inbred DA/Han and PVG.1AV1 that share the RT.1AV1 MHC haplotype were bred to create F1 generation, 7 couples of F1 with DA/Han and PVG.1AV1 females founders generated F2. F3 generation originated from breeding 50 random couples Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden advanced_intercross_line Unknown RRID:RGD_2298494 2298498 W/Gaox Generated by selective breeding of a spontaneously mutant male from the inbred colony of Wistar rats at the Animal Research Center of Guangzhou Traditional Chinese Medicine University Department of Urology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China inbred Unknown RRID:RGD_2298498 2298772 WFfzHsd Fuzzy rat Sparse fuzzy hair animals with Wistar Furth background found at Tulane University to Skin and Cancer Hospital, Temple University, Philadelphia to Harlan (1987) Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00340 2299122 F344-Tasp1Tn(sb-T2/Bart3)2.219Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Tasp1 gene. PhysGen mutant Extinct (as of 2017-01-26) Tasp1Tn(sb-T2/Bart3)2.219Mcwi 2299101 3 128002479 128228127 1 - by flanking markers 3 139347611 139588372 1 - by flanking markers 3 132888785 133131213 1 - by flanking markers 3 127176416 127408039 1 - by flanking markers RRID:RGD_2299122 2299123 F344-AW921689Tn(sb-T2/Bart3)2.209Mcwi this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PhysGen mutant Unknown AW921689Tn(sb-T2/Bart3)2.209Mcwi 2299108 RRID:RGD_2299123 2299124 F344-Ubqln4Tn(sb-T2/Bart3)2.230Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 4th intron of the Ubqln4 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Ubqln4Tn(sb-T2/Bart3)2.230Mcwi 2299109 2 180669525 180684724 1 - by flanking markers 2 207318101 207333435 1 - by flanking markers 2 187915701 187931035 1 - by flanking markers 2 174012726 174028062 1 - by flanking markers RRID:RRRC_00350 2299125 F344-Ccdc85aTn(sb-T2/Bart3)2.248Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Ccdc85a gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Ccdc85aTn(sb-T2/Bart3)2.248Mcwi 2299113 14 109197317 109434306 1 - by flanking markers 14 112609601 112636341 1 - by flanking markers 14 112719482 112900724 1 - by flanking markers 14 102126574 102359207 1 - by flanking markers RRID:RRRC_00356 2299126 F344-Kcnip4Tn(sb-T2/Bart3)2.225Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Kcnip4 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Kcnip4Tn(sb-T2/Bart3)2.225Mcwi 2299100 14 66284290 67452628 1 - by flanking markers 14 65635533 66780362 1 - by flanking markers 14 65549362 66749181 1 - by flanking markers 14 61380699 62531399 1 - by flanking markers RRID:RRRC_00348 2299127 F344-Eva1aTn(sb-T2/Bart3)2.233Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Eva1a gene. PhysGen mutant Extinct (as of 2017-01-26) Eva1aTn(sb-T2/Bart3)2.233Mcwi 2299094 4 116280880 116330122 1 - by flanking markers 4 177461600 177511382 1 - by flanking markers 4 112714023 112823659 1 - by flanking markers 4 114593773 114643011 1 - by flanking markers RRID:RGD_2299127 2299128 F344-Lama2Tn(sb-T2/Bart3)2.2013Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 38th intron of the Lama2 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Lama2Tn(sb-T2/Bart3)2.2013Mcwi 2299103 1 18203466 18885462 1 - by flanking markers 1 20002787 20647256 1 - by flanking markers 1 18491264 19143486 1 - by flanking markers 1 17672675 18320641 1 - by flanking markers RRID:RRRC_00432 2299129 F344-Lrrc4cTn(sb-T2/Bart3)2.224Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Lrrc4c gene. PhysGen, Transposagen mutant Extinct (as of 2017-01-26) Lrrc4cTn(sb-T2/Bart3)2.224Mcwi 2299107 3 80921606 82413671 1 - by flanking markers 3 92119546 93502229 1 - by flanking markers 3 85421169 86821783 1 - by flanking markers 3 82305244 83684039 1 - by flanking markers RRID:RGD_2299129 2299130 F344-AdaTn(sb-T2/Bart3)2.237Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 7th intron of the Ada gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-13) AdaTn(sb-T2/Bart3)2.237Mcwi 2299093 3 154636530 154660637 1 - by flanking markers 3 166306001 166330108 1 - by flanking markers 3 160115840 160139947 1 - by flanking markers 3 152398745 152422854 1 - by flanking markers RRID:RRRC_00426 2299131 F344-Grk1Tn(sb-T2/Bart3)2.234Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 3rd intron of the Grk1 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Grk1Tn(sb-T2/Bart3)2.234Mcwi 2299115 16 80979323 80991796 1 - by flanking markers 16 80641991 80657693 1 - by flanking markers 16 81153489 81165442 1 - by flanking markers 16 76122501 76135792 1 - by flanking markers RRID:RRRC_00388 2299132 F344-Cadm1Tn(sb-T2/Bart3)2.229Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Cadm1 gene. PhysGen mutant Extinct (as of 2017-01-26) Cadm1Tn(sb-T2/Bart3)2.229Mcwi 2299116 8 50765645 51108962 1 - by flanking markers 8 50460752 50796128 1 - by flanking markers 8 51858906 52200591 1 - by flanking markers 8 47847836 48178703 1 - by flanking markers RRID:RGD_2299132 2299133 F344-Rap1gds1Tn(sb-T2/Bart3)2.251Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 9th intron of the Rap1gds1 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Rap1gds1Tn(sb-T2/Bart3)2.251Mcwi 2299098 2 236522381 236638692 1 - by flanking markers 2 262787595 262899803 1 - by flanking markers 2 244258550 244370983 1 - by flanking markers 2 227500366 227645243 1 - by flanking markers RRID:RRRC_00357 2299134 F344-Ppapdc1aTn(sb-T2/Bart3)2.207Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 6th intron of the Ppapdc1a gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Ppapdc1aTn(sb-T2/Bart3)2.207Mcwi 2299105 1 188518590 188643804 1 - by flanking markers 1 209449940 209577459 1 - by flanking markers 1 202432366 202560628 1 - by flanking markers 1 183829794 183959319 1 - by flanking markers RRID:RRRC_00347 2299135 F344-Mgat4cTn(sb-T2/Bart3)2.244Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Mgat4c gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Mgat4cTn(sb-T2/Bart3)2.244Mcwi 2299106 7 40171454 40383441 1 - by flanking markers 7 43829446 44052611 1 - by flanking markers 7 43249369 44024278 1 - by flanking markers 7 36709564 37485810 1 - by flanking markers RRID:RRRC_00354 2299136 F344-SnphTn(sb-T2/Bart3)2.214Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 3rd intron of the Snph gene. PhysGen mutant Extinct (as of 2017-01-26) SnphTn(sb-T2/Bart3)2.214Mcwi 2299117 3 141921547 141961697 1 - by flanking markers 3 153455882 153496985 1 - by flanking markers 3 147102394 147143576 1 - by flanking markers 3 140098540 140139342 1 - by flanking markers RRID:RGD_2299136 2299137 F344-Erbb4Tn(sb-T2/Bart3)2.208Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Erbb4 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Erbb4Tn(sb-T2/Bart3)2.208Mcwi 2299110 9 66843898 67967970 1 - by flanking markers 9 74804287 75310350 1 - by flanking markers 9 75021790 76178936 1 - by flanking markers 9 69523733 70596743 1 - by flanking markers RRID:RRRC_00383 2299138 F344-Nrxn2Tn(sb-T2/Bart3)2.250Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 16th intron of the Nrxn2 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Nrxn2Tn(sb-T2/Bart3)2.250Mcwi 2299118 1 209211740 209318064 1 - by flanking markers 1 228789462 228899340 1 - by flanking markers 1 221792191 221908047 1 - by flanking markers 1 203726420 203842301 1 - by flanking markers RRID:RRRC_00449 2299139 F344-Dnhd1Tn(sb-T2/Bart3)2.243Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 3rd intron of the Dnhd1 gene. PhysGen mutant Extinct (as of 2017-01-26) Dnhd1Tn(sb-T2/Bart3)2.243Mcwi 2299114 1 163380065 163467261 1 - by flanking markers 1 177487073 177576072 1 - by flanking markers 1 170473792 170570220 1 - by flanking markers 1 159990785 160077990 1 - by flanking markers RRID:RGD_2299139 2299140 F344-DccTn(sb-T2/Bart3)2.205Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Dcc gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) DccTn(sb-T2/Bart3)2.205Mcwi 2298938 18 68026795 69140741 1 - by flanking markers 18 65688901 66793126 1 - by flanking markers 18 66518213 67629801 1 - by flanking markers 18 64868987 65972783 1 - by flanking markers RRID:RRRC_00384 2299141 F344-Ppp2r2bTn(sb-T2/Bart3)2.239Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 6th intron of the Ppp2r2b gene. PhysGen mutant Extinct (as of 2017-01-26) Ppp2r2bTn(sb-T2/Bart3)2.239Mcwi 2299104 18 35865837 36318308 1 - by flanking markers 18 36647298 37076455 1 - by flanking markers 18 36985709 37421383 1 - by flanking markers 18 34653716 35080889 1 - by flanking markers RRID:RGD_2299141 2299142 F344-Inpp4bTn(sb-T2/Bart3)2.232Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Inpp4b gene. PhysGen, Transposagen mutant Extinct (as of 2017-01-26) Inpp4bTn(sb-T2/Bart3)2.232Mcwi 2299095 19 27722430 28363639 1 - by flanking markers 19 40508684 41132035 1 - by flanking markers 19 29592889 30341528 1 - by flanking markers 19 25920189 26670085 1 - by flanking markers RRID:RGD_2299142 2299143 F344-Kif16bTn(sb-T2/Bart3)2.200Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 11th intron of the Kif16b gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Kif16bTn(sb-T2/Bart3)2.200Mcwi 2299111 3 130967515 131250402 1 - by flanking markers 3 143103727 143381598 1 - by flanking markers 3 136596621 136936809 1 - by flanking markers 3 129974692 130254194 1 - by flanking markers RRID:RRRC_00346 2299144 F344-TrdnTn(sb-T2/Bart3)2.238Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 9th intron of the Trdn gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) TrdnTn(sb-T2/Bart3)2.238Mcwi 2299099 1 24514752 24925948 1 - by flanking markers 1 26865461 27248423 1 - by flanking markers 1 25403390 25787664 1 - by flanking markers 1 23955651 24410494 1 - by flanking markers RRID:RRRC_00368 2299145 F344-Rprd1aTn(sb-T2/Bart3)2.247Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Rprd1a gene. PhysGen mutant Extinct (as of 2017-01-26) Rprd1aTn(sb-T2/Bart3)2.247Mcwi 2299096 18 16283291 16328357 1 - by flanking markers 18 16209135 16256883 1 - by flanking markers 18 16450160 16497913 1 - by flanking markers 18 15791418 15839338 1 - by flanking markers RRID:RGD_2299145 2299146 F344-PtpreTn(sb-T2/Bart3)236Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Ptpre gene. PhysGen mutant Extinct (as of 2017-01-26) PtpreTn(sb-T2/Bart3)236Mcwi 2299097 1 195263489 195303249 1 - by flanking markers 1 214818446 214920034 1 - by flanking markers 1 207820719 207987123 1 - by flanking markers 1 190344331 190494815 1 - by flanking markers RRID:RGD_2299146 2299147 F344-Prr5lTn(sb-T2/Bart3)2.228Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Prr5l gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Prr5lTn(sb-T2/Bart3)2.228Mcwi 2299112 3 86868129 86948468 1 - by flanking markers 3 97950297 98119477 1 - by flanking markers 3 91290207 91461208 1 - by flanking markers 3 88001951 88173532 1 - by flanking markers RRID:RRRC_00349 2299148 F344-Immp1lTn(sb-T2/Bart3)2.246Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 3rd intron of the Immp1l gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Immp1lTn(sb-T2/Bart3)2.246Mcwi 2299102 3 91408864 91436603 1 - by flanking markers 3 102575250 102646194 1 - by flanking markers 3 95955126 96024316 1 - by flanking markers 3 92385329 92450557 1 - by flanking markers RRID:RRRC_00355 2300018 SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcr Selective back cross breeding was done with SHRSP/Izm and Zucker fatty rats for 12 generations to introduce Lepr locus of chr 5 from Zucker fatty rats into SHRSP/Izm Mukogawa Women's University, Nishinomiya, Hyogo Japan, National BioResource Project for the Rat in Japan congenic Live Animals Diabetes Obesity; Cardio Hypertension RRID:RGD_2300018 2300195 EHC.BN-(D14Rat43-D14Rat132)/Kyu EHC/Seac and BN/Seac were crossed to get F1 progeny which were in turn backcrossed with EHC/Seac and genotyped. Animals with completely replaced background were identified and mated to get homozygous congenics Kyushu University, Fukuoka, Japan congenic Unknown 14 79256324 107101727 1 - by flanking markers 14 78419915 110102984 1 - by flanking markers 14 78446303 110402569 1 - by flanking markers 14 100147356 100147478 1 - by flanking markers RRID:RGD_2300195 2300215 SHR.BN-(D10Mgh3-D10Rat85)/Ipcv Congenic substrain derived from SHR.BN-(D10Mgh3-Srebf1)/Ipcv Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic congenic Unknown 10 48994688 100090454 1 - by flanking markers 10 49018990 98640289 1 - by flanking markers 10 49239646 98939361 1 - by flanking markers 10 47494000 95600487 1 - by flanking markers RRID:RGD_2300215 2300216 SHR-Tg(PEPCK-SREBF1)1Ipcv SHR/OlaIpcv zygotes were microinjected with a construct containing rat PEPCK promoter fused to truncated human cDNA encoding SREBF1 (SREBP-1c isoform) and human growth hormone poly-A signal Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic transgenic Unknown SREBF1 69473 RRID:RGD_2300216 2300217 SHR.BN-(D10Mgh3-Srebf1)/Ipcv 53.7Mbp segment of chr 10 including Srebf1 gene from BN/Crl was introgressed into the SHR/OlaIpcv background Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic congenic Unknown Srebf1 69423 10 46461684 100090454 1 - by flanking markers 10 46326015 98640289 1 - by flanking markers 10 46570996 98939361 1 - by flanking markers 10 45007637 95600487 1 - by flanking markers RRID:RGD_2300217 2301079 F344-Lrrc7Tn(sb-T2/Bart3)2.253Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Lrrc7. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Lrrc7Tn(sb-T2/Bart3)2.253Mcwi 2301078 2 256228792 256644029 1 - by flanking markers 2 283549882 283934360 1 - by flanking markers 2 264910594 265300860 1 - by flanking markers 2 247147752 247533332 1 - by flanking markers RRID:RRRC_00360 2301080 F344-Lrrc4cTn(sb-T2/Bart3)2.254Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 5th intron of the Lrrc4c gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Lrrc4cTn(sb-T2/Bart3)2.254Mcwi 2301076 3 80921606 82413671 1 - by flanking markers 3 92119546 93502229 1 - by flanking markers 3 85421169 86821783 1 - by flanking markers 3 82305244 83684039 1 - by flanking markers RRID:RRRC_00359 2301081 F344-Mmel1Tn(sb-T2/Bart3)2.255Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Mmel1. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Mmel1Tn(sb-T2/Bart3)2.255Mcwi 2301077 5 171675007 171703353 1 - by flanking markers 5 175729143 175759868 1 - by flanking markers 5 172273450 172303905 1 - by flanking markers 5 165431278 165461716 1 - by flanking markers RRID:RRRC_00358 2301246 SS.LEW-(D3Rat61-D3Wox1)/Ayd A segment of chromosome 3 was transferred from LEW/Crlc into the SS/Jr background. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 3 147852788 168149595 1 - by flanking markers 3 158115782 182470017 1 - by flanking markers 3 153381237 174632112 1 - by flanking markers 3 145925360 166177555 1 - by flanking markers RRID:RGD_2301246 2301247 SS.LEW-(D16Got3-D16Rat112)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D16Mit2-D16Chm23)/Ayd Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 16 64718 3531727 1 - by flanking markers 16 773329 4149422 1 - by flanking markers 16 778415 4203372 1 - by flanking markers 16 110590 3447332 1 - by flanking markers RRID:RGD_2301247 2301248 SS.LEW-(D3Got33-D3Chm68)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D3Rat52-D3Rat17)/Ayd Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 3 45100293 60708929 1 - by flanking markers 3 55769295 71451283 1 - by flanking markers 3 49115270 64892832 1 - by flanking markers 3 47769862 62962984 1 - by flanking markers RRID:RGD_2301248 2301249 SS.LEW-(D18Rat30-D18Chm29)/Ayd A segment of chromosome 3 was transferred from LEW/Clrc into the SS/Jr background. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 5682011 12249935 1 - by flanking markers 18 5795276 15461904 1 - by flanking markers 18 5825946 15691464 1 - by flanking markers 18 5584537 11796356 1 - by flanking markers RRID:RGD_2301249 2301315 LE/Orl Long-Evans/Cryptorchid Obtained from Centre Nationale de la Researche Scientifique, Orleans, France Centre Nationale de la Researche Scientifique, Orleans, France inbred Unknown RRID:RGD_2301315 2301330 KH Develped at the International Foundation for the Study of Rat Genetics and Rodent Pest Control (INTROGENE) Oklahoma City, Oklahoma International Foundation for the Study of Rat Genetics and Rodent Pest Control (INTROGEN) Oklahoma City, Oklahoma inbred Unknown RRID:RGD_2301330 2301367 SHRSP.WKY-(D2Mit5-D2Rat133)/Gcrc Congenic substrain generated by crossing SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc males with SHRSP/Gcrc females then intercrossed to fix the small congenic fragment University of Glasgow, Western Infirmary, Glasgow, UK congenic Unknown 2 66680022 170817807 1 - by flanking markers 2 86560119 197513270 1 - by flanking markers 2 66828049 178177553 1 - by flanking markers 2 66118275 164552628 1 - by flanking markers RRID:RGD_2301367 2301368 SHRSP.WKY-(D2Wox15-D2Rat133)/Gcrc Congenic substrain generated by crossing SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc males with SHRSP/Gcrc females then intercrossed to fix the small congenic fragment University of Glasgow, Western Infirmary, Glasgow, UK congenic Unknown 2 170817613 170817807 1 - by flanking markers 2 197513076 197513270 1 - by flanking markers 2 178177359 178177553 1 - by flanking markers 2 164552433 164552628 1 - by flanking markers RRID:RGD_2301368 2301369 SHRSP.WKY-(D2Rat132-D2Rat53)/Gcrc Congenic substrain generated by crossing SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc males with SHRSP/Gcrc females then intercrossed to fix the small congenic fragment University of Glasgow, Western Infirmary, Glasgow, UK congenic Unknown 2 196277776 204077687 1 - by flanking markers 2 223058573 230770799 1 - by flanking markers 2 203613889 211301253 1 - by flanking markers 2 188657176 196146841 1 - by flanking markers RRID:RGD_2301369 2301370 SHRSP.WKY-(D2Wox9-D2Rat231)/Gcrc Congenic substrain generated by crossing SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc males with SHRSP/Gcrc females then intercrossed to fix the small congenic fragment University of Glasgow, Western Infirmary, Glasgow, UK congenic Unknown 2 141259937 190384899 1 - by flanking markers 2 161271919 216143762 1 - by flanking markers 2 141583337 196645063 1 - by flanking markers 2 136445150 183048631 1 - by flanking markers RRID:RGD_2301370 2301371 SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc Congenic substrain generated by crossing SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc males with SHRSP/Gcrc females then intercrossed to fix the small congenic fragment University of Glasgow, Western Infirmary, Glasgow, UK congenic Unknown Gstm1|Vcam1|S1pr1 2755|3952|61958 2 182724363 216711836 1 - by flanking markers 2 209270725 241761983 1 - by flanking markers RRID:RGD_2301371 2301381 SS.LEW-(D18Chm41-D18Rat92)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 30891173 53898282 1 - by flanking markers 18 30797572 52299753 1 - by flanking markers 18 31109532 53083766 1 - by flanking markers 18 29804982 51515008 1 - by flanking markers RRID:RGD_2301381 2301382 SS.LEW-(D18Chm91-D18Rat67)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 12677191 23780206 1 - by flanking markers 18 15053338 23867696 1 - by flanking markers 18 15274408 24147513 1 - by flanking markers 18 12205066 23012468 1 - by flanking markers RRID:RGD_2301382 2301383 SS.LEW-(D18Chm31-D18Rat55)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 2848113 54856651 1 - by flanking markers 18 2761846 53346447 1 - by flanking markers 18 2745212 54108474 1 - by flanking markers 18 52539763 52539863 1 - by flanking markers RRID:RGD_2301383 2301384 SS.LEW-(D18Chm41-D18Rat45)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 30891173 77511190 1 - by flanking markers 18 30797572 76318715 1 - by flanking markers 18 31109532 77212332 1 - by flanking markers 18 29804982 74055742 1 - by flanking markers RRID:RGD_2301384 2301385 SS.LEW-(D18Rat29-D18Rat55)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 13904295 54856651 1 - by flanking markers 18 13042236 53346447 1 - by flanking markers 18 13257458 54108474 1 - by flanking markers 18 13529795 52539863 1 - by flanking markers RRID:RGD_2301385 2301386 SS.LEW-(D18Rat61-D18Rat45)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 61571526 77511190 1 - by flanking markers 18 60167906 76318715 1 - by flanking markers 18 60971508 77212332 1 - by flanking markers 18 58805687 74055742 1 - by flanking markers RRID:RGD_2301386 2301387 SS.LEW-(D18Rat67-D18Rat55)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 23779885 54856651 1 - by flanking markers 18 23867550 53346447 1 - by flanking markers 18 24147367 54108474 1 - by flanking markers 18 23012321 52539863 1 - by flanking markers RRID:RGD_2301387 2301388 SS.LEW-(D18Chm56-D18Rat55)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 49014933 54856651 1 - by flanking markers 18 47711090 53346447 1 - by flanking markers 18 48499359 54108474 1 - by flanking markers 18 46969392 52539863 1 - by flanking markers RRID:RGD_2301388 2301700 F344-Spata13Tn(sb-T2/Bart3)2.267Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Spata13 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Spata13Tn(sb-T2/Bart3)2.267Mcwi 2301697 15 39722469 39849214 1 - by flanking markers 15 44749770 44878760 1 - by flanking markers 15 40937652 41066645 1 - by flanking markers 15 34778479 34907645 1 - by flanking markers RRID:RRRC_00373 2301701 F344-PtpraTn(sb-T2/Bart3)2.261Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 5th intron of the Ptpra gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) PtpraTn(sb-T2/Bart3)2.261Mcwi 2301698 3 118061713 118171300 1 - by flanking markers 3 129475237 129582992 1 - by flanking markers 3 122976066 123084585 1 - by flanking markers 3 117650146 117759744 1 - by flanking markers RRID:RRRC_00370 2301702 F344-Sf4Tn(sb-T2/Bart3)2.264Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 4th intron of the Sf4 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Sf4Tn(sb-T2/Bart3)2.264Mcwi 2301696 16 19835921 19866795 1 - by flanking markers 16 20950430 21047301 1 - by flanking markers 16 21100923 21131795 1 - by flanking markers 16 19352659 19383533 1 - by flanking markers RRID:RRRC_00371 2301937 BN.GH-(D18Rat41-D18Mgh4)/Mcwi Male GH/Omr were intercrossed with female BN/Elh then F1 male offspring was backcrossed to female BN/Elh, marker-assisted selection strategy was used to select the males who were backcrossed to BN for 10 generations Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 18 59279066 79585133 1 - by flanking markers 18 57699045 79012652 1 - by flanking markers 18 58476128 79948741 1 - by flanking markers 18;6 56594589;118921813 76477940;118921891 1 - by flanking markers;1 - by flanking markers RRID:RGD_2301937 2301938 BN.GH-(D6Mit12-D6Rat15)/Mcwi Male GH/Omr were intercrossed with female BN/Elh then F1 male offspring was backcrossed to female BN/Elh, marker-assisted selection strategy was used to select the males who were backcrossed to BN for 10 generations Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 6 3158401 105011726 1 - by flanking markers 6 2916444 113050815 1 - by flanking markers 6 104890044 104890216 1 - by flanking markers 6 100873387 100873560 1 - by flanking markers RRID:RGD_2301938 2301939 BN.GH-(D2Rat22-D2Mgh11)/Mcwi Male GH/Omr were intercrossed with female BN/Elh then F1 male offspring was backcrossed to female BN/Elh, marker-assisted selection strategy was used to select the males who were backcrossed to BN for 10 generations Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 2 69302718 69303085 1 - by flanking markers 2 88968735 223460027 1 - by flanking markers 2 69243686 204022555 1 - by flanking markers 2 68462860 189039377 1 - by flanking markers RRID:RGD_2301939 2301986 BN.GH-(D2Rat22-D2Mgh11)(D18Rat41-D18Mgh4)/Mcwi desired segments from chr 2 and 18 from GH/Omr were introgressed in BN/Elh background Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown RRID:RGD_2301986 2301987 BN.GH-(D2Rat22-D2Mgh11)(D6Mit12-D6Rat15)/Mcwi desired segments from chr 2 and 6 from GH/Omr were introgressed in BN/Elh background Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown RRID:RGD_2301987 2301988 BN.GH-(D6Mit12-D6Rat15)(D18Rat41-D18Mgh4)/Mcwi desired segments from chr 6 and 18 from GH/Omr were introgressed in BN/Elh background Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown RRID:RGD_2301988 2301989 BN.GH-(D2Rat22-D2Mgh11)(D6Mit12-D6Rat15)(D18Rat41-D18Mgh4)/Mcwi desired segments from chr 2, 6 and 18 from GH/Omr were introgressed in BN/Elh background Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown RRID:RGD_2301989 2302067 F344/DuCrlSwe Substrain of Fischer rats maintained at Malmo, Sweden Section for Medical Inflammation Research, Biomedical Center, Lund University, Sweden inbred Unknown RRID:RGD_2302067 2302080 Rhd:F344,GK-G21 GK/Swe and F344/Swe were bred to create F1 generation, couples of F1 with GK/Swe and F344/Swe females founders generated F2. F3 generation originated from breeding random couples which were intercrossed to get further generations Section for Medical Inflammation Research, Biomedical Center, Lund University, Sweden advanced_intercross_line Unknown RRID:RGD_2302080 2302081 DA.E3-(D11Got79-D11Wox5)/Rhd This congenic strain was obtained by the conventional backcross breeding to the parental DA/ZtmRhd strain with positive selection of microsatellite markers. The region corresponding with he production of RF-Igl ambda antibodies was mapped to a narrower region 'D11Got79-D11Rat50.' Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown 11 82238710 85432136 1 - by flanking markers 11 86800287 90495881 1 - by flanking markers 11 83727048 87444587 1 - by flanking markers 11 80039141 83440803 1 - by flanking markers RRID:RGD_2302081 2302106 SHRSP.WKY-(D1Rat44-D1Arb21)/Izm SHRSP.WKY-(Klk1-D1Rat116)/Izm was backcrossed with SHRSP/Izm, resulting F1 were intercrossed to obtain F2 recombinant individuals were selected by marker assisted selection National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 153754139 187092492 1 - by flanking markers 1 167707459 206277202 1 - by flanking markers 1 161493758 199254774 1 - by flanking markers 1 150872626 182418476 1 - by flanking markers RRID:RGD_2302106 2302108 SHRSP.WKY-(D1Mgh5-D1Wox29)/Izm SHRSP.WKY-(Klk1-D1Rat116)/Izm was backcrossed with SHRSP/Izm, resulting F1 were intercrossed to obtain F2 recombinant individuals were selected by marker assisted selection National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 78134304 124614852 1 - by flanking markers 1 80946174 131822376 1 - by flanking markers 1 79689548 130779320 1 - by flanking markers 1 78430536 123350581 1 - by flanking markers RRID:RGD_2302108 2302109 SHRSP.WKY-(D1Mgh5-D1Rat44)/Izm SHRSP.WKY-(Klk1-D1Rat116)/Izm was backcrossed with SHRSP/Izm, resulting F1 were intercrossed to obtain F2 recombinant individuals were selected by marker assisted selection National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 78134304 153754250 1 - by flanking markers 1 80946174 167707569 1 - by flanking markers 1 79689548 161493868 1 - by flanking markers 1 78430536 150872737 1 - by flanking markers RRID:RGD_2302109 2302110 SHRSP.WKY-(Apbb1-D1Arb21)/Izm SHRSP.WKY-(Klk1-D1Rat116)/Izm was backcrossed with SHRSP/Izm, resulting F1 were intercrossed to obtain F2 recombinant individuals were selected by marker assisted selection National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension Apbb1 2122 1 163282918 187092492 1 - by flanking markers 1 177393531 206277202 1 - by flanking markers 1 170387625 199254774 1 - by flanking markers 1 159896889 182418476 1 - by flanking markers RRID:RGD_2302110 2302132 SHRSP-Tg(Tagln-ACE2)6918Bdr Trangenic line generated by microinjecting 2.8 kb fragment of smooth muscle 22 alpha promoter and cDNA for human ACE2 gene into SHRSP embryos Max-Delbruck-Center for Molecular Medicine, Berlin-Buch, Germany transgenic Unknown Tagln|ACE2 3723|1347174 RRID:RGD_2302132 2302141 F344-Tg(Cyp1a1-Ren2)10Jmul Generated by using cytochrome P-450 promoter, rat Cyp1a1 to drive mouse Ren2 gene expression. The integration site was on Y chromosome as suggested by Southern blot analysis. University of Edinburgh Medical School, Edinburgh, UK transgenic Unknown Cyp1a1|Ren2 2458|1622375 RRID:RGD_2302141 2302148 SHR-Tg(Ef1a-Cd36)10Ipcv Generated by microinjecting SHR/OlaIpcv zygotes with wild type Cd36 DNA from WKY cloned into Invitrogen pEF1/V5-HisA vector Czech Academy of Sciences, Prague, Czech Republic transgenic Unknown Cd36 2301 RRID:RGD_2302148 2302149 SHR-Tg(Ef1a-Cd36)19Ipcv Generated by microinjecting SHR/OlaIpcv zygotes with wild type Cd36 DNA from WKY cloned into Invitrogen pEF1/V5-HisA vector Czech Academy of Sciences, Prague, Czech Republic transgenic Unknown Cd36 2301 RRID:RGD_2302149 2302150 SHR-Tg(Ef1a-Cd36)93Ipcv Generated by microinjecting SHR/OlaIpcv zygotes with wild type Cd36 DNA from WKY cloned into Invitrogen pEF1/V5-HisA vector Czech Academy of Sciences, Prague, Czech Republic transgenic Unknown Cd36 2301 RRID:RGD_2302150 2302151 SHR-Tg(Ef1a-Cd36)106Ipcv Generated by microinjecting SHR/OlaIpcv zygotes with wild type Cd36 DNA from WKY cloned into Invitrogen pEF1/V5-HisA vector Czech Academy of Sciences, Prague, Czech Republic transgenic Unknown Cd36 2301 RRID:RGD_2302151 2302279 F344.SDT-(D3Wox9-D3Arb20)/Kbe Female F344/NSlc were crossed with male SDT/CrljJcl, then female F1 were backcrossed to male F344/NSlc; male and female heterozygous carriers were backcrossed to male F344/NSlc, desired region was checked by SSLP markers Kobe University School of Medicine, Chuo-ku, Kobe, Japan congenic Unknown 3 47722501 47722628 1 - by flanking markers 3 58456360 58456486 1 - by flanking markers 3 51821710 51821836 1 - by flanking markers 3 50436913 50437042 1 - by flanking markers RRID:RGD_2302279 2302387 DA.ACI-(D2Mit12-D2Mgh29)/Nsi Congenic strain created by backcrossing DA/BklArbNsi and ACI/SegHsd which resulted in introgressing a 52.6 Mb from ACI into DA/BklArbNsi North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-18) arthritis/autoimmunity studies 2 174730375 227310008 1 - by flanking markers 2 74640967 201405160 1 - by flanking markers 2 181990297 235290110 1 - by flanking markers 2 168358098 218414891 1 - by flanking markers RRID:RRRC_00667 2302649 F344-Nsun4Tn(sb-T2/Bart3)2.286Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 3rd intron of the Nsun4 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Nsun4Tn(sb-T2/Bart3)2.286Mcwi 2302645 5 136277224 136297339 1 - by flanking markers 5 138152068 138689234 1 - by flanking markers 5 134885377 134905492 1 - by flanking markers 5 129511224 129532498 1 - by flanking markers RRID:RRRC_00435 2302650 F344-Enox1Tn(sb-T2/Bart3)2.282Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 6th intron of the Enox1 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Enox1Tn(sb-T2/Bart3)2.282Mcwi 2302641 15 58555747 58762870 1 - by flanking markers 15 63013519 63564418 1 - by flanking markers 15 59331134 59884512 1 - by flanking markers 15 52517833 53079752 1 - by flanking markers RRID:RRRC_00470 2302651 F344-Klra1Tn(sb-T2/Bart3)2.279Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Klra1 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Klra1Tn(sb-T2/Bart3)2.279Mcwi 2302638 4 168892865 168928286 1 - by flanking markers 4 227986994 228022556 1 - by flanking markers 4 165426365 165460140 1 - by flanking markers 4 164873735 164985429 1 - by flanking markers RRID:RRRC_00431 2302652 F344-Pde4dTn(sb-T2/Bart3)2.285Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Pde4d gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Pde4dTn(sb-T2/Bart3)2.285Mcwi 2302644 2 40196097 41311012 1 - by flanking markers 2 59292847 60521358 1 - by flanking markers 2 40219999 41468551 1 - by flanking markers 2 40014933 41529190 1 - by flanking markers RRID:RRRC_00436 2302653 F344-Mov10Tn(sb-T2/Bart3)2.281Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 18th intron of the Mov10 gene. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Mov10Tn(sb-T2/Bart3)2.281Mcwi 2302647 2 200053185 200075536 1 - by flanking markers 2 226696252 226717551 1 - by flanking markers 2 207277088 207301245 1 - by flanking markers 2 192292041 192315142 1 - by flanking markers RRID:RRRC_00377 2302654 F344-Csmd3Tn(sb-T2/Bart3)2.288Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 23rd intron of the Csmd3 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Csmd3Tn(sb-T2/Bart3)2.288Mcwi 2302637 7 83586771 84932392 1 - by flanking markers 7 86689912 87802035 1 - by flanking markers 7 86695703 88072106 1 - by flanking markers 7 78747322 80066466 1 - by flanking markers RRID:RRRC_00390 2302655 F344-Tmtc2Tn(sb-T2/Bart3)2.276Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Tmtc2 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Tmtc2Tn(sb-T2/Bart3)2.276Mcwi 2302646 7 43667983 44133854 1 - by flanking markers 7 47197110 47603261 1 - by flanking markers 7 47179596 47586777 1 - by flanking markers 7 40392377 40806685 1 - by flanking markers RRID:RRRC_00376 2302656 F344-Casp7Tn(sb-T2/Bart3)2.280Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Casp7 gene. PhysGen mutant Extinct (as of 2017-01-26) Casp7Tn(sb-T2/Bart3)2.280Mcwi 2302642 1 262689300 262721591 1 - by flanking markers 1 284572208 284623736 1 - by flanking markers 1 277190557 277242779 1 - by flanking markers 1 255437195 255476737 1 - by flanking markers RRID:RGD_2302656 2302657 F344-Orc3Tn(sb-T2/Bart3)2.275Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 4th intron of the Orc3 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Orc3Tn(sb-T2/Bart3)2.275Mcwi 2302648 5 51172243 51226644 1 - by flanking markers 5 54588113 54644440 1 - by flanking markers 5 50019159 50075533 1 - by flanking markers 5 49123758 49181552 1 - by flanking markers RRID:RRRC_00375 2302658 F344-BbxTn(sb-T2/Bart3)2.291Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Bbx gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) BbxTn(sb-T2/Bart3)2.291Mcwi 2302640 11 51655446 51799132 1 - by flanking markers 11 56153038 56397255 1 - by flanking markers 11 52983286 53228557 1 - by flanking markers 11 50381249 50628934 1 - by flanking markers RRID:RRRC_00428 2302659 F344-Snx25Tn(sb-T2/Bart3)2.270Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 5th intron of the Snx25 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Snx25Tn(sb-T2/Bart3)2.270Mcwi 2302636 16 49415658 49518663 1 - by flanking markers 16 49051539 49159381 1 - by flanking markers 16 49328958 49432415 1 - by flanking markers 16 46134552 46238471 1 - by flanking markers RRID:RRRC_00374 2302660 F344-Nectin1Tn(sb-T2/Bart3)2.284Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 5th intron of the Pvrl1. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Nectin1Tn(sb-T2/Bart3)2.284Mcwi 2302639 8 46739657 46799051 1 - by flanking markers 8 46714981 46777484 1 - by flanking markers 8 48094233 48198499 1 - by flanking markers 8 44101776 44164863 1 - by flanking markers RRID:RRRC_00378 2302661 F344-Gramd1bTn(sb-T2/Bart3)2.287Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Gramd1b gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Gramd1bTn(sb-T2/Bart3)2.287Mcwi 2302635 8 43260379 43429258 1 - by flanking markers 8 61200537 61378124 1 - by flanking markers 8 44160634 44399110 1 - by flanking markers 8 40654492 40893869 1 - by flanking markers RRID:RRRC_00389 2302662 F344-Slc7a11Tn(sb-T2/Bart3)2.266Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 6th intron of the Slc7a11 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Slc7a11Tn(sb-T2/Bart3)2.266Mcwi 2302643 2 139241142 139317101 1 - by flanking markers 2 158930294 159004937 1 - by flanking markers 2 139453774 139528479 1 - by flanking markers 2 134382002 134517622 1 - by flanking markers RRID:RRRC_00372 2302666 Scr:sP Sardinian alcohol-preferring rats sP/Scr rats are derived from the selectively bred Sardinian alcohol-preferring rats (sP). This colony began with founders obtained after 32 generations of selective breeding for ethanol preference from Wistar stock by Prof. G.L. Gessa (University of Cagliari). Since receipt, this substrain has been maintained at the Scripps Institute for 24 generations of intra-line, unselected breeding. The Scripps Research Institute, LaJolla, California outbred Unknown RRID:RGD_2302666 2302984 SS.BN-(D13Rat151-D13Rat197)/Mcwi SS/JrHsdMcwi were crossed with SS-Chr 13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 64083138 80109632 1 - by flanking markers 13 71941043 87516988 1 - by flanking markers 13 66971778 66971975 1 - by flanking markers 13 61825626 61825824 1 - by flanking markers RRID:RGD_2302984 2302985 SS.BN-(D13Rat111-D13Got22)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13;13;13;5 32030139;42627610;45828608;97701780 32030259;42627837;45828716;97703112 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 13;13;13;5 54791498;40421740;51509286;100631702 54791605;40421859;51509512;100633034 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 5;13;13;13 96601805;49720575;46444570;35301263 96603137;49720682;46444796;35301382 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 13;13;5 41184022;30395351;93541170 41184251;30395471;93542503 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers RRID:RGD_2302985 2302986 SS.BN-(D13Rat88-D13Rat91)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 42627610 46912163 1 - by flanking markers 13 51509286 55853202 1 - by flanking markers 13 46444570 50799665 1 - by flanking markers 13 41184022 45417941 1 - by flanking markers RRID:RGD_2302986 2302987 SS.BN-(D13Rat7-D13Rat60)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 1084268 13053933 1 - by flanking markers 13 19518130 32069874 1 - by flanking markers 13 14279081 26919398 1 - by flanking markers 13 11766535 23001904 1 - by flanking markers RRID:RGD_2302987 2302989 SS.BN-(D13Rat57-D13Rat192)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 80109432 100133413 1 - by flanking markers 13 87516787 109040616 1 - by flanking markers 13 104392076 104392271 1 - by flanking markers 13 95722244 95722440 1 - by flanking markers RRID:RGD_2302989 2302994 SS.BN-(D13Rat127-D13Rat61)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 55373161 63301678 1 - by flanking markers 13 23200281 71179041 1 - by flanking markers 13 17996178 66204711 1 - by flanking markers 13 53382878 61058159 1 - by flanking markers RRID:RGD_2302994 2302995 SS.BN-(D13Rat115-D13Rat101)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 35719010 49428577 1 - by flanking markers 13 44763184 58314767 1 - by flanking markers 13 39639775 53264877 1 - by flanking markers 13 34778619 47841255 1 - by flanking markers RRID:RGD_2302995 2302996 SS.BN-(D13Rat7-D13Rat88)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 1084268 38329229 1 - by flanking markers 13 19518130 47267192 1 - by flanking markers 13 14279081 42155682 1 - by flanking markers 13 11766535 37262232 1 - by flanking markers RRID:RGD_2302996 2302997 SS.BN-(D13Rat91-D13Got45)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 44872181 63301678 1 - by flanking markers 13 53846466 71179041 1 - by flanking markers 13 48776655 66204711 1 - by flanking markers 13 43437904 61058159 1 - by flanking markers RRID:RGD_2302997 2302999 SS.BN-(D13Rat178-D13Got45)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 57566232 64083335 1 - by flanking markers 13 65516837 71941240 1 - by flanking markers 13 60528276 66971975 1 - by flanking markers 13 55481090 61825824 1 - by flanking markers RRID:RGD_2302999 2303000 SS.BN-(D13Rat123-D13Rat150)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 44872181 57566359 1 - by flanking markers 13 53846466 65516963 1 - by flanking markers 13 48776655 60528402 1 - by flanking markers 13 43437904 55481217 1 - by flanking markers RRID:RGD_2303000 2303001 SS.BN-(D13Rat111-D13Rat127)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 32030139 49428577 1 - by flanking markers 13 40421740 58314767 1 - by flanking markers 13 35301263 53264877 1 - by flanking markers 13 30395351 47841255 1 - by flanking markers RRID:RGD_2303001 2303002 SS.BN-(D13Rat123-D13Rat197)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 42627610 76779489 1 - by flanking markers 13 51509286 83929327 1 - by flanking markers 13 46444570 79034003 1 - by flanking markers 13 41184022 73485113 1 - by flanking markers RRID:RGD_2303002 2303003 SS.BN-(D13Rat7-D13Rat127)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 1084268 49428577 1 - by flanking markers 13 19518130 58314767 1 - by flanking markers 13 14279081 53264877 1 - by flanking markers 13 11766535 47841255 1 - by flanking markers RRID:RGD_2303003 2303004 SS.BN-(D13Rat115-D13Rat61)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 63301384 67752598 1 - by flanking markers 13 71178814 75143303 1 - by flanking markers 13 66204484 70172216 1 - by flanking markers 13 61057931 64901750 1 - by flanking markers RRID:RGD_2303004 2303005 SS.BN-(D13Rat127-D13Rat77)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 55373161 57922038 1 - by flanking markers 13 23200281 65861506 1 - by flanking markers 13 17996178 60876578 1 - by flanking markers 13 53382878 55829942 1 - by flanking markers RRID:RGD_2303005 2303006 SS.BN-(D13Rat101-D13Rat46)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 46269934 72638941 1 - by flanking markers 13 55560677 79943775 1 - by flanking markers 13 75026588 75026713 1 - by flanking markers 13 69535761 69535887 1 - by flanking markers RRID:RGD_2303006 2303007 SS.BN-(D13Rat127-D13Rat46)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 55373161 72638941 1 - by flanking markers 13 23200281 79943775 1 - by flanking markers 13 17996178 75026713 1 - by flanking markers 13 53382878 69535887 1 - by flanking markers RRID:RGD_2303007 2303008 SS.BN-(D13Rat61-D13GRat197)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 63301384 76779489 1 - by flanking markers 13 71178814 83929327 1 - by flanking markers 13 66204484 79034003 1 - by flanking markers 13 61057931 73485113 1 - by flanking markers RRID:RGD_2303008 2303009 SS.BN-(D13Rat183-D13Rat192)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 77336098 100133413 1 - by flanking markers 13 84460970 109040616 1 - by flanking markers 13 79567081 104392271 1 - by flanking markers 13 74023918 95722440 1 - by flanking markers RRID:RGD_2303009 2303010 SS.BN-(D13Got51-D13Rat192)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 69494047 100133413 1 - by flanking markers 13 76974692 109040616 1 - by flanking markers 13 72031440 104392271 1 - by flanking markers 13 66706825 95722440 1 - by flanking markers RRID:RGD_2303010 2303011 SS.BN-(D13Got51-D13Rat57)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 69494047 80109632 1 - by flanking markers 13 76974692 87516988 1 - by flanking markers 13 72031440 72031708 1 - by flanking markers 13 66706825 66707096 1 - by flanking markers RRID:RGD_2303011 2303099 F344-Kcnh7Tn(sb-T2/Bart3)2.295Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 8th intron of the Kcnh7 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Kcnh7Tn(sb-T2/Bart3)2.295Mcwi 2303095 3 44657361 45153509 1 - by flanking markers 3 55325680 55822973 1 - by flanking markers 3 48662450 49168716 1 - by flanking markers 3 47329338 47822122 1 - by flanking markers RRID:RRRC_00430 2303100 F344-Slc16a12Tn(sb-T2/Bart3)2.298Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Slc16a12 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Slc16a12Tn(sb-T2/Bart3)2.298Mcwi 2303097 1 238643040 238665699 1 - by flanking markers 1 260197556 260275962 1 - by flanking markers 1 252976071 253054500 1 - by flanking markers 1 232184004 232262170 1 - by flanking markers RRID:RRRC_00438 2303101 F344-Kcnab1Tn(sb-T2/Bart3)2.300Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Kcnab1 gene. PhysGen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Kcnab1Tn(sb-T2/Bart3)2.300Mcwi 2303094 2 154837841 155145882 1 - by flanking markers 2 174966379 175400010 1 - by flanking markers 2 155555798 156011438 1 - by flanking markers 2 149137025 149603540 1 - by flanking markers RRID:RRRC_00471 2303102 F344-Dnah11Tn(sb-T2/Bart3)2.293Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 25th intron of the Dnah11 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Dnah11Tn(sb-T2/Bart3)2.293Mcwi 2303098 6 145190931 145516859 1 - by flanking markers 6 154698519 155011384 1 - by flanking markers 6 145784893 146099212 1 - by flanking markers 6 138839175 139155554 1 - by flanking markers RRID:RRRC_00429 2303103 F344-Pebp4Tn(sb-T2/Bart3)2.299Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Pebp4 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Pebp4Tn(sb-T2/Bart3)2.299Mcwi 2303096 15 50225405 50460627 1 - by flanking markers 15 55252902 55466149 1 - by flanking markers 15 51528587 51740626 1 - by flanking markers 15 44920946 45134188 1 - by flanking markers RRID:RRRC_00455 2303116 SPRD.WKY-(D10Rat91-D10Rat135)/Ibmm SPRD/HanZtm were crossed with WKY/HanZtm and F1 males were backcrossed with SPRD/HanZtm. Heterozygous carriers were bred to SPRD/HanZtm. Universite Libre de Bruxelles, Institut de Biologie et de Medecine Moleculaires, Gosselies, Belgium congenic Unknown 10 9762188 108776963 1 - by flanking markers 10 8619955 108145987 1 - by flanking markers 10 9841807 108540162 1 - by flanking markers 10 9658275 104670812 1 - by flanking markers RRID:RGD_2303116 2303117 SPRD.WKY-(D5Rat190-D5Rat114)(D18Rat102-D18Rat44)/Ibmm Double congenic strain generated by intercrossing SPRD.WKY-(D5Rat190-D5Rat114)/Ibmm and SPRD.WKY-(D18Rat102-D18Rat44)/Ibmm; F1 animals were intercrossed and F2 screened for heterozygousity by markers Universite Libre de Bruxelles, Institut de Biologie et de Medecine Moleculaires, Gosselies, Belgium congenic Unknown RRID:RGD_2303117 2303148 SS.SHR-(D9Wox16-D9Rat76)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Wox16-D9Rat64)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 18476042 33497026 1 - by flanking markers 9 24681016 40929956 1 - by flanking markers 9 25819185 41261265 1 - by flanking markers 9 22198773 36962591 1 - by flanking markers RRID:RGD_2303148 2303149 SS.SHR-(D9Wox16-D9Mco73)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Wox16-D9Rat64)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region. Medical College of Ohio, Toledo, Ohio congenic Unknown 9 18476042 47764357 1 - by flanking markers 9 24681016 55323208 1 - by flanking markers 9 25819185 55627498 1 - by flanking markers 9 22198773 50687400 1 - by flanking markers RRID:RGD_2303149 2303150 SS.SHR-(D9Mco74-D9Rat64)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Wox16-D9Rat64)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 25174989 91131755 1 - by flanking markers 9 31484855 98715585 1 - by flanking markers 9 32677807 99041268 1 - by flanking markers 9 28806563 92491790 1 - by flanking markers RRID:RGD_2303150 2303151 SS.SHR-(D9Wox16-D9Mco77)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Wox16-D9Rat64)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 18476042 54083264 1 - by flanking markers 9 24681016 64294638 1 - by flanking markers 9 25819185 64491201 1 - by flanking markers 9 22198773 56777289 1 - by flanking markers RRID:RGD_2303151 2303152 SS.SHR-(D9Mco72-D9Mco93)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Wox16-D9Rat64)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 44842118 90249887 1 - by flanking markers 9 52352690 97845437 1 - by flanking markers 9 52686874 98164303 1 - by flanking markers 9 47902208 91616855 1 - by flanking markers RRID:RGD_2303152 2303153 SS.SHR-(D9Rat7-D9Mco93)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Wox16-D9Rat64)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 77170797 90249887 1 - by flanking markers 9 83451810 97845437 1 - by flanking markers 9 83686153 98164303 1 - by flanking markers 9 79271511 91616855 1 - by flanking markers RRID:RGD_2303153 2303154 SS.SHR-(D9Wox16-D9Mco85)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Wox16-D9Rat64)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 18476042 76456066 1 - by flanking markers 9 24681016 82659881 1 - by flanking markers 9 25819185 82890620 1 - by flanking markers 9 22198773 78595166 1 - by flanking markers RRID:RGD_2303154 2303504 LEW/JmsNgs congenital hydrocephalus rat Lewis rats from Tokyo Medical Insitute to Seiwa Institute of Experimental Animals, Hydrocephalus was found the rats at F27 in 1980, these were sent to Dr. Yasutaka Noda at Center for Animal Experiments, Kurume University, The hydrocephalus rat strains have been maintained out by selective breeding. National BioResource Project for the Rat in Japan National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Dentistry RRID:RGD_2303759 2303761 SD-Tg(CAG-EGFP)4Osb Green rat This transgenic strain carries the enhanced green fluorescent protein (EGFP) gene driven by ubiquitous CAG promoter. This transgenic strain was established by Japan SLC, Inc. National BioResource Project for the Rat in Japan transgenic Live Animals RRID:RGD_2303761 2303779 OLETF-Chr 14F344/Tj Chromosome 14 from F344 is introgressed in OLETF background National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2303779 2303784 SHR-Chr 4WKY/Tkyo Chromosome 3 from WKY is introgressed into the genomic background of SHR National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2303784 2303785 SHRSP-Chr 3WKY/Tkyo Chromosome 3 from WKY is introgressed into the genomic background of SHRSP National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2303785 2303792 WTC.ZI-Atrnzi/Kyo Zitter rat was detected in a Sprague Dawley colony (SD) in Hannover in 1978 by Rehm. 1983 introduced to Kyoto University and established ZI/Kyo. A second zi allele carrying line with WTC backgrund was established at Kyoto University National BioResource Project for the Rat in Japan congenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Neurobiology Atrnzi 40902832 RRID:RGD_2303792 2303793 WTC.DMY-dmy/Kyo Congenic strain derived by transferring dmy locus from DMY/Kyo on WTC/Kyo background at Kyoto University National BioResource Project for the Rat in Japan congenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Neurobiology RRID:RGD_2303793 2303971 OLETF.F344-(D7Mgh16-D7Mgh20)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1999. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 96491967 96492203 1 - by flanking markers 7 100584458 100584693 1 - by flanking markers 7 100004559 100004794 1 - by flanking markers 7 91256311 91256547 1 - by flanking markers RRID:RGD_2303971 2303972 BN-Chr 13SS/Mcwi A cross of BN and SS strains which results in a BN genomic background with a SS chromosome introgressed PhysGen consomic Unknown RRID:RGD_2303972 2303973 OLETF.F344-(D10Wox7-D10Wox6)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1999-2000. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 10 103550924 103551039 1 - by flanking markers 10 102101261 102101375 1 - by flanking markers 10 102427604 102427718 1 - by flanking markers 10 98952626 98952741 1 - by flanking markers RRID:RGD_2303973 2303976 F344-Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Cyp7b1 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi 2303974 2 103102679 103271273 1 - by flanking markers 2 122442002 122610354 1 - by flanking markers 2 102701903 102871257 1 - by flanking markers 2 100502791 100669713 1 - by flanking markers RRID:RRRC_00472 2303977 F344-Ano3Tn(sb-T2/Bart3)2.307Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Tmem16c gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Ano3Tn(sb-T2/Bart3)2.307Mcwi 2303975 3 96123925 96237157 1 - by flanking markers 3 108441370 108751911 1 - by flanking markers 3 101843516 102203368 1 - by flanking markers 3 97235671 97550090 1 - by flanking markers RRID:RRRC_00477 2303978 F344.OLETF-(D7Mgh16-D7Mgh20)(D14Rat8-D14Rat26)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2303978 2303979 F344.OLETF-(D7Mgh16-D7Mgh20)(D14Rat23-D14Rat12)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2303979 2303986 WKAH.LEC-Atp7bhts/Tj A congenic strain produced by 8 generation backcrosses to WKAH strain in 1989. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2021-02-11) Cancer Atp7bhts 11532742 16 74607988 74680080 1 - by flanking markers 16 74495179 74575822 1 - by flanking markers 16 74865516 74944935 1 - by flanking markers 16 69952286 70024404 1 - by flanking markers RRID:RGD_2303986 2303987 F344.OLETF-(D17Mgh4-Edn1)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity Edn1 2532 17 28303886 28309775 1 - by flanking markers 17 24117499 24124188 1 - by flanking markers 17 22136814 22143745 1 - by flanking markers 17 22454924 22460812 1 - by flanking markers RRID:RGD_2303987 2303988 F344.OLETF-(D14Rat23-D14Rat12)(D8Rat54-D8Mgh17)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2303988 2303989 F344.OLETF-(D9Mgh8-D9Mit2)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 9 33374546 63705951 1 - by flanking markers 9 40808491 70797404 1 - by flanking markers 9 41139089 71771476 1 - by flanking markers 9 36840385 66437242 1 - by flanking markers RRID:RGD_2303989 2303990 F344.OLETF-(D1Mit20-D1Mgh26)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 1 94356875 176616212 1 - by flanking markers 1 100372156 194998184 1 - by flanking markers 1 188051098 188051234 1 - by flanking markers 1 172711200 172711337 1 - by flanking markers RRID:RGD_2303990 2303991 F344.OLETF-(D7Rat31-D7Rat35)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 20307479 28488710 1 - by flanking markers 7 24326613 32338830 1 - by flanking markers 7 24175337 32258115 1 - by flanking markers 7 18169505 26029351 1 - by flanking markers RRID:RGD_2303991 2303992 F344.OLETF-(D5Mgh29-D5Mgh22)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 5 157584332 157584492 1 - by flanking markers 5 160953624 160953783 1 - by flanking markers 5 157212263 157212422 1 - by flanking markers 5 151005994 151006154 1 - by flanking markers RRID:RGD_2303992 2303993 OLETF.F344-(D9Mgh8-D9Mit2)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1999. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 9 33374546 63705951 1 - by flanking markers 9 40808491 70797404 1 - by flanking markers 9 41139089 71771476 1 - by flanking markers 9 36840385 66437242 1 - by flanking markers RRID:RGD_2303993 2303994 F344.OLETF-(D5Mgh4-D5Rat21)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 5 99344678 99344842 1 - by flanking markers 5 102264251 102264414 1 - by flanking markers 5 98224053 98224216 1 - by flanking markers 5 95112065 95112231 1 - by flanking markers RRID:RGD_2303994 2303995 F344.OLETF-(D8Rat54-D8Mgh17)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 8 19796514 73102155 1 - by flanking markers 8 21850030 79245063 1 - by flanking markers 8 74917593 80840067 1 - by flanking markers 8 69349194 69349344 1 - by flanking markers RRID:RGD_2303995 2303996 F344.Cg-Foxn1rnu/Kyo This congenic strain was established as a strain with the genetic background of F344/N onto which a segment from the nude rat containing the Foxn1rnu was transferred. Originally, hairless mutant (rnu) was observed in a colony of outbred hooded rats maintained at the Rowett Research Institute in Scotland. Backcrossing started at Central Institute for Experimental Animals in 1979 and thereafter the subline was transported to the Institute of Laboratory Animals Graduate School of Medicine, Kyoto University. National BioResource Project for the Rat in Japan congenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Immunology; Cancer Foxn1 3970 10 64243323 64256847 1 - by flanking markers 10 66004940 66030134 1 - by flanking markers 10 65621142 65634666 1 - by flanking markers 10 63251400 63273710 1 - by flanking markers RRID:RGD_2303996 2303997 F344.OLETF-(D7Mgh8-D7Mgh16)(D14Rat23-D14Rat26)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2303997 2303998 WKAH.LEC-Ptprkthid/Tj A congenic strain produced by 8 generation backcrosses to WKAH strain in 1989. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cancer Ptprk 619706 1 17328563 17752200 1 - by flanking markers 1 18602550 19574958 1 - by flanking markers 1 17445052 18058266 1 - by flanking markers 1 16738896 17236687 1 - by flanking markers RRID:RGD_2303998 2303999 F344.OLETF-(D14Rat8-D14Rat26)(D14Rat18-D14Rat22)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2303999 2304000 F344.OLETF-(D12Wox5-D12Rat21)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 12 43801711 43801909 1 - by flanking markers 12 17721341 50319569 1 - by flanking markers 12 15714609 48536609 1 - by flanking markers 12 13635523 42767729 1 - by flanking markers RRID:RGD_2304000 2304001 F344.OLETF-(D14Rat23-D14Rat12)(D14Rat8-D14Rat26)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2304001 2304002 F344.OLETF-(D11Mgh4-D11Mgh1)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 11 61504311 84560241 1 - by flanking markers 11 65784365 89808503 1 - by flanking markers 11 62653194 86714631 1 - by flanking markers 11 59802622 82566702 1 - by flanking markers RRID:RGD_2304002 2304003 F344.OLETF-(D16Rat19-D16Rat13)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 16 35339929 77968799 1 - by flanking markers 16 35126908 77759249 1 - by flanking markers 16 35307110 78172206 1 - by flanking markers 16 31951520 73187298 1 - by flanking markers RRID:RGD_2304003 2304004 F344.OLETF-(D7Mit2-D7Mgh16)(D14Rat23-D14Rat26)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2304004 2304016 BUF.ACI-(D4Rat192-D4Rat66)/Ncc This congenic strain in the BUF background that had homozygous ACI chr 4 was developed by speed congenic method. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cancer 4 161023350 161023765 1 - by flanking markers 4 224435359 224435481 1 - by flanking markers 4 157417581 157417703 1 - by flanking markers 4 157704599 157704722 1 - by flanking markers RRID:RGD_2304016 2304017 F344.CVD-Unc5ccvd/Kyo CVD ( Cerebellar vermis defect) rat originated from spontanious mutation of LEW inbred at Osaka Prefecture University in 1992. A mutation in Unc5c has been identified in CVD rats. A congenic strain was produced by backcrossing CVD to F344/NSlc strain at Kyoto University. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-04-05) Neurobiology Unc5c|Unc5ccvd 735109|12802355 2 239365109 239721231 1 - by flanking markers 2 265573406 265926229 1 - by flanking markers 2 247045813 247397483 1 - by flanking markers 2 230180353 230535219 1 - by flanking markers RRID:RGD_2304017 2304018 BUF.ACI-(D4Rat226-D4Rat109)/Ncc This congenic strain in the BUF background that had homozygous ACI chr 4 was developed by speed congenic method. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cancer 4 61542056 117094107 1 - by flanking markers 4 61331785 178404466 1 - by flanking markers 4 61612433 113728420 1 - by flanking markers 4 62837725 115401611 1 - by flanking markers RRID:RGD_2304018 2304019 BUF.ACI-(D15Rat68-D15Rat29)/Ncc This congenic strain in the BUF background that had homozygous ACI chr 15 was developed by speed congenic method. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cancer 15 62521452 108387411 1 - by flanking markers 15 67139660 67139799 1 - by flanking markers 15 63498932 63499071 1 - by flanking markers 15 56484420 56484560 1 - by flanking markers RRID:RGD_2304019 2304020 ACI.BUF-(D15Rat97-D15Rat29)/Ncc This congenic strain in the ACI background that had homozygous BUF/Nac chr 15 was developed by speed congenic method. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cancer 15 78048029 108387411 1 - by flanking markers 15 82573157 82573380 1 - by flanking markers 15 79033484 79033707 1 - by flanking markers 15 71477067 71477291 1 - by flanking markers RRID:RGD_2304020 2304037 DDI/Ddia dokkyo diabetes insipidus rat Strain developed at Dokkyo University, School of Medicine, Tochigi, Japan National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Metabolism; Urology RRID:RGD_2304037 2304038 OP/Jtt Opacitas Maintained in sib mating between opacitas rats (heterozygoutes) and normal rats. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Ophthalmology RRID:RGD_2304038 2304039 WIC-Tgrdw/Kts Established from a closed colony of Wistar-Imamichi (WIC) rats as a spontaneous mutant exhibiting congenital dwarfism (rdw), is inherited as an autosomal recessive. This strain has a spontaneous missense mutation, G2320R, in the thyroglobul gene. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-04-21) Metabolism Tgrdw 12879860 7 104035776 104220754 1 - by flanking markers 7 107399165 107602400 1 - by flanking markers 7 107467260 107652897 1 - by flanking markers 7 98418293 98603210 1 - by flanking markers RRID:RGD_2304039 2304040 F344.OP-Op/Jtt Opacitas rats (heterozygtes) are backcorssed with F344/DuCrj. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Ophthalmology RRID:RGD_2304040 2304041 SD-Tg(CAG-Rgn)Slc Transgenic srain derived by injecting SD rats with a vector containing ubiquitous CAG promoter and the rat Rgn gene National BioResource Project for the Rat in Japan transgenic Live Animals Osteosis Rgn 3560 RRID:RGD_2304041 2304045 F344.ZUC-Leprfa(D14Rat23-D14Rat12)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 2002. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 1764386 41707592 1 - by flanking markers 14 2222207 61886417 1 - by flanking markers 14 2227825 61783215 1 - by flanking markers 14 1217606 39153750 1 - by flanking markers RRID:RGD_2304045 2304046 F344.ZUC-(Leprfa)(D7Rat16-D7Mgh20)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 2002. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 108647236 108647376 1 - by flanking markers 7 112143411 112143550 1 - by flanking markers 7 112204378 112204517 1 - by flanking markers 7 102920123 102920263 1 - by flanking markers RRID:RGD_2304046 2304047 F344.ZUC-Leprfa/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 2001. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity Lepr|Leprfa 3001|13432153 RRID:RGD_2304047 2304050 F344.OLETF-(D14Rat23-D14Rat55)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 1764386 27571792 1 - by flanking markers 14 2222207 27510976 1 - by flanking markers 14 2227825 27686562 1 - by flanking markers 14 1217606 25656577 1 - by flanking markers RRID:RGD_2304050 2304051 F344.OLETF-(D14Rat8-D14Rat12)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 32584630 41707592 1 - by flanking markers 14 32389647 61886417 1 - by flanking markers 14 32593926 61783215 1 - by flanking markers 14 30320092 39153750 1 - by flanking markers RRID:RGD_2304051 2304052 F344.OLETF-(D14Rat55-D14Rat12)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 27571487 41707592 1 - by flanking markers 14 27510756 61886417 1 - by flanking markers 14 27686342 61783215 1 - by flanking markers 14 25656356 39153750 1 - by flanking markers RRID:RGD_2304052 2304053 F344.OLETF-(D14Rat23-D14Rat5)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 1764386 11589751 1 - by flanking markers 14 2222207 11868597 1 - by flanking markers 14 2227825 11926177 1 - by flanking markers 14 1217606 10277166 1 - by flanking markers RRID:RGD_2304053 2304054 F344.OLETF-(D14Rat23-D14Rat10)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 1764386 33157602 1 - by flanking markers 14 2222207 32957654 1 - by flanking markers 14 2227825 33163485 1 - by flanking markers 14 1217606 30883947 1 - by flanking markers RRID:RGD_2304054 2304055 F344.OLETF-(D14Wox1-D14Rat12)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 41707423 41707592 1 - by flanking markers 14 61886249 61886417 1 - by flanking markers 14 61783047 61783215 1 - by flanking markers 14 39153581 39153750 1 - by flanking markers RRID:RGD_2304055 2304056 F344.OLETF-(D14Rat23-D14Wox14)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 1764386 21885861 1 - by flanking markers 14 2222207 21925011 1 - by flanking markers 14 2227825 22009966 1 - by flanking markers 14 1217606 1217776 1 - by flanking markers RRID:RGD_2304056 2304057 F344.OLETF-(D14Rat12)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in JapanD14Rat143-D14Rat12)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 19738306 41707592 1 - by flanking markers 14 19754557 61886417 1 - by flanking markers 14 19847829 61783215 1 - by flanking markers 14 18212584 39153750 1 - by flanking markers RRID:RGD_2304058 2304059 F344.OLETF-(D14Rat5-D14Rat12)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 11589293 41707592 1 - by flanking markers 14 11868448 61886417 1 - by flanking markers 14 11926028 61783215 1 - by flanking markers 14 10277016 39153750 1 - by flanking markers RRID:RGD_2304059 2304060 F344.OLETF-(D14Wox14-D14Rat12)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 21885743 41707592 1 - by flanking markers 14 21924894 61886417 1 - by flanking markers 14 22009849 61783215 1 - by flanking markers 14 39153581 39153750 1 - by flanking markers RRID:RGD_2304060 2304061 F344.OLETF-(D14Rat23)/Tj Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1999. Afterwards, maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 1764386 1764554 1 - by flanking markers 14 2222207 2222374 1 - by flanking markers 14 2227825 2227992 1 - by flanking markers 14 1217606 1217776 1 - by flanking markers RRID:RGD_2304061 2304063 KDP-Tg(H2Kd-Cblb)2Nyo Homozygous Cblb rats are usually infertile in both sexes and are therefore maintained by crossing heterozygous individuals (segregating inbred strain). National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Diabetes Obesity; Immunology Cblb 620535 RRID:RGD_2304063 2304064 KDP-Tg(H2Kd-Cblb)1Nyo Homozygous Cblb rats are usually infertile in both sexes and are therefore maintained by crossing heterozygous individuals (segregating inbred strain). National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Diabetes Obesity; Immunology Cblb 620535 RRID:RGD_2304064 2304065 KDP-Tg(INS-Cblb)1Nyo Homozygous Cblb rats are usually infertile in both sexes and are therefore maintained by crossing heterozygous individuals (segregating inbred strain). National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Diabetes Obesity; Immunology Cblb 620535 RRID:RGD_2304065 2304066 KDP-Tg(CAG-Cblb)1Nyo Homozygous Cblb rats are usually infertile in both sexes and are therefore maintained by crossing heterozygous individuals (segregating inbred strain). National BioResource Project for the Rat in Japan transgenic Unknown Cblb 620535 RRID:RGD_2304066 2304074 WKY.BUF-Tsr1d/Mna This congenic strain was established as a strain with the genetic background of WKY onto which a segment from the BUF/Mna containing the thymus susceptible gene of rat-1, Tsr-1 (on chr.7) has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cancer RRID:RGD_2304074 2304075 ACI.BUF-Pur1/Mna This congenic strain was established as a strain with the genetic background of ACI onto which a segment from the BUF/Mna containing the proteinuria-susceptible gene, Pur1 (on chr.13) has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Urology RRID:RGD_2304075 2304076 WKY.BUF-Thym1, Thym2/Mna This double congenic strain was established as a strain with the genetic background of WKY onto which a segment from the BUF/Mna containing the thymus enlargement, Ten1 (Thym1) (on chr.1) and Ten2 (Thym2)(on chr. 13) has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo (as of 2018-03-14) Cancer RRID:RGD_2304076 2304077 WKY.BUF-Pur1s/Mna This congenic strain was established as a strain with the genetic background of WKY onto which a segment from the BUF/Mna containing the proteinuria-susceptible locus, on chr.13 has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Urology RRID:RGD_2304077 2304078 ACI.BUF-Ten1/Mna This congenic strain was established as a strain with the genetic background of ACI onto which a segment from the BUF/Mna containing the thymus enlargement, Ten1 (on chr.1) has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo RRID:RGD_2304078 2304079 WKY.BUF-Ten1/Mna This congenic strain was established as a strain with the genetic background of WKY onto which a segment from the BUF/Mna containing the thymus enlargement, Ten1 (on chr.1) has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo RRID:RGD_2304079 2304080 ACI.BUF-Aftm1/Mna This congenic strain was established as a strain with the genetic background of ACI onto which a segment from the BUF/Mna has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_2304080 2304081 WKY.BUF-Pur1w/Mna This congenic strain was established as a strain with the genetic background of WKY onto which a segment from the BUF/Mna containing the proteinuria-susceptible locus, on chr.13 has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Urology RRID:RGD_2304081 2304082 WKY.BUF-Ten2/Mna This congenic strain was established as a strain with the genetic background of WKY onto which a segment from the BUF/Mna containing the thymus enlargement, Ten2 (on chr.13) has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Urology RRID:RGD_2304082 2304083 ACI.BUF-Ten2/Mna This congenic strain was established as a strain with the genetic background of ACI onto which a segment from the BUF/Mna containing the thymus enlargement, Ten2 (on chr.13) has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo RRID:RGD_2304083 2304093 SHRSP.WKY-(D1Rat106-D1Arb21)/Izm Developed by the depositor National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 139471535 187092492 1 - by flanking markers 1 146068162 206277202 1 - by flanking markers 1 145140412 199254774 1 - by flanking markers 1 137184788 182418476 1 - by flanking markers RRID:RGD_2304093 2304094 SHRSP.WKY-(D1Smu12-D1Rat44)/Izm This is a congenic strain developed by the depositor. National BioResource Project for the Rat in Japan congenic Unknown Cardio Hypertension 1 153754139 153754250 1 - by flanking markers 1 167707459 167707569 1 - by flanking markers 1 161493758 161493868 1 - by flanking markers 1 150872626 150872737 1 - by flanking markers RRID:RGD_2304094 2304095 W-Tg(Plcb2-WGA-EGFP)F1Abek This is a transgenic strain developed by the depositor. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo RRID:RGD_2304095 2304096 SHRSP.WKY-(D1Rat49-D1Arb21)/1Izm Developed by the depositor National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 157497884 187092492 1 - by flanking markers 1 171330622 206277202 1 - by flanking markers 1 165129767 199254774 1 - by flanking markers 1 154464069 182418476 1 - by flanking markers RRID:RGD_2304096 2304097 SHRSP.WKY-(D1Rat49-D1Arb21)/2Izm This is a congenic strain developed by the depositor. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 157497884 187092492 1 - by flanking markers 1 171330622 206277202 1 - by flanking markers 1 165129767 199254774 1 - by flanking markers 1 154464069 182418476 1 - by flanking markers RRID:RGD_2304097 2304098 SHRSP.WKY-(D1Smu13-D1Arb21)/Izm Developed by the depositor National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 187092235 187092492 1 - by flanking markers 1 206276946 206277202 1 - by flanking markers 1 199254518 199254774 1 - by flanking markers 1 182418219 182418476 1 - by flanking markers RRID:RGD_2304098 2304099 SHRSP.WKY-(D1Smu12-D1Arb21)/Izm This is a congenic strain developed by the depositor. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 187092235 187092492 1 - by flanking markers 1 206276946 206277202 1 - by flanking markers 1 199254518 199254774 1 - by flanking markers 1 182418219 182418476 1 - by flanking markers RRID:RGD_2304099 2304100 SHRSP.WKY-(D1Rat39-D1Arb21)/Izm This is a congenic strain developed by the depositor. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 125983422 187092492 1 - by flanking markers 1 133172202 206277202 1 - by flanking markers 1 132134307 199254774 1 - by flanking markers 1 124668437 182418476 1 - by flanking markers RRID:RGD_2304100 2304101 SHRSP.WKY-(D1Rat43-D1Arb21)/Izm This is a congenic strain developed by the depositor. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 187092235 187092492 1 - by flanking markers 1 206276946 206277202 1 - by flanking markers 1 144634295 199254774 1 - by flanking markers 1 182418219 182418476 1 - by flanking markers RRID:RGD_2304101 2304102 SHRSP.WKY-(D1Mgh5-D1Rat106)/Izm This is a congenic strain developed by the depositor. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 78134304 139471673 1 - by flanking markers 1 80946174 146282094 1 - by flanking markers 1 79689548 145354344 1 - by flanking markers 1 78430536 137184926 1 - by flanking markers RRID:RGD_2304102 2304104 W-Tg(Plcb2-WGA-EGFP)M1Abek This is a transgenic strain developed by the depositor. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo RRID:RGD_2304104 2304120 SHRSP/2Ta Kyo > Ta (1972) National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension RRID:RGD_2304120 2304121 DA.WF-(D1Mit1-D1Mit3)/Kop This congenic strain in the DA background by introgressing a segment from WF National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cancer 1 146971846 146971983 1 - by flanking markers 1 162692213 162692800 1 - by flanking markers 1 156446196 156446783 1 - by flanking markers 1 144267353 144267916 1 - by flanking markers RRID:RGD_2304121 2304122 DA.WF-(D1Mgh21-D1Mgh10)(D4Mit11-Nos3)/Kop This congenic strain in the DA background by introgressing a segment from WF National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cancer RRID:RGD_2304122 2304123 DA.WF-(D4Mit11-Nos3)/Kop This congenic strain in the DA background by introgressing a segment from WF National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cancer Nos3 3186 4 6158847 91330856 1 - by flanking markers 4 7333272 157291359 1 - by flanking markers 4 7321908 92484312 1 - by flanking markers 4 10793834 91360801 1 - by flanking markers RRID:RGD_2304123 2304124 DA.WF-(D1Mgh21-D1Mgh10)(D4Mit11-Nos3)(D1Mit1-D1Mit3)/Kop This congenic strain in the DA background by introgressing a segment from WF National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cancer RRID:RGD_2304124 2304125 DRH.F344-(D1Mgh8-D1Mgh12)/Shigm desired fragment from F344 was introgressed into DRH background National BioResource Project for the Rat in Japan, Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cancer 1 156124624 247322277 1 - by flanking markers 1 169999389 270717037 1 - by flanking markers 1 163796316 163796432 1 - by flanking markers 1 153136852 153136969 1 - by flanking markers RRID:RGD_2304125 2304200 W-Tg(CAG-ABO*A)32Jmsk This transgenic strain expresses the transferase A of the ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase ) driven by the CAG promoter established at Jichi Medical School. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Hematology Abo3 628609 RRID:RGD_2304200 2304201 F344-Galntl6Tn(sb-T2/Bart3)2.311McwiRrrc These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 4th intron of the Galntl6 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Galntl6Tn(sb-T2/Bart3)2.311Mcwi 2304194 16 34557663 35853849 1 - by flanking markers 16 34380195 35619972 1 - by flanking markers 16 34551052 35803840 1 - by flanking markers 16 31192880 32443979 1 - by flanking markers RRID:RRRC_00450 2304202 F344-RGD1565323Tn(sb-T2/Bart3)2.312Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of RGD1565323. PhysGen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) RGD1565323Tn(sb-T2/Bart3)2.312Mcwi 2304193 17 38022396 38039975 1 - by flanking markers 17 34865901 34882646 1 - by flanking markers 17 32973695 32990440 1 - by flanking markers 17 31661713 31678816 1 - by flanking markers RRID:RRRC_00437 2304203 W-Tg(CAG-DsRed2/GFP)1Jmsk DsRed2/GFP double-reporter transgenic rat driven under a ubiquitous CAG promoter. In this system, DsRed2 expression was replaced with GFP expression after Cre recombinase-mediated excision established at Jichi Medical School. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Development RRID:RGD_2304203 2304204 W-Tg(CAG-ABO*B)13Jmsk This transgenic strain expresses the transferase B of the ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase ) driven by the CAG promoter established at Jichi Medical School. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Hematology Abo3 628609 RRID:RGD_2304204 2304205 W-Tg(Alb-DsRed2)34Jmsk This transgenic strain expresses the DsRed2 (DsRed: red fluorescent protein) liver-specific under the direction of the mouse albumin enhancer/promoter established at Jichi Medical School. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo; Cryopreserved Sperm Development RRID:RGD_2304205 2304206 W-Tg(CAG-DsRed2/GFP)15Jmsk DsRed2/GFP double-reporter transgenic rat driven under a ubiquitous CAG promoter. In this system, DsRed2 expression was replaced with GFP expression after Cre recombinase-mediated excision established at Jichi Medical School. National BioResource Project for the Rat in Japan, Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm Development RRID:RRRC_00300 2304207 F344-LzicTn(sb-T2/Bart3)2.309Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 6th intron of the Lzic gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) LzicTn(sb-T2/Bart3)2.309Mcwi 2304196 5 166567412 166579423 1 - by flanking markers 5 170076617 170089776 1 - by flanking markers 5 166430305 166443485 1 - by flanking markers 5 159928260 159941512 1 - by flanking markers RRID:RRRC_00434 2304208 F344-Rapgef4Tn(sb-T2/Bart3)2.314Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 11th intron of the Rapgef4 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Rapgef4Tn(sb-T2/Bart3)2.314Mcwi 2304197 3 54396312 54717148 1 - by flanking markers 3 65122705 65409814 1 - by flanking markers 3 58632338 58925127 1 - by flanking markers 3 56809388 57101332 1 - by flanking markers RRID:RRRC_00479 2304209 F344-RorbTn(sb-T2/Bart3)2.304Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Rorb gene. PhysGen mutant Extinct (as of 2017-01-26) RorbTn(sb-T2/Bart3)2.304Mcwi 2304199 1 222545682 222726307 1 - by flanking markers 1 241354340 241541103 1 - by flanking markers 1 234252757 234442597 1 - by flanking markers 1 216363629 216544390 1 - by flanking markers RRID:RGD_2304209 2304210 W-Tg(Alb-DsRed2)42Jmsk This transgenic strain expresses the DsRed2 (DsRed: red fluorescent protein) liver-specific under the direction of the mouse albumin enhancer/promoter established at Jichi Medical School. National BioResource Project for the Rat in Japan, Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm Development RRID:RRRC_00260 2304211 W-Tg(CAG-cre)81Jmsk This strain expresses the cre recombinase ubiquitously driven by CAG promoter. The majority of expression of the transgene is detected in the skeletal muscles established at Jichi Medical School. National BioResource Project for the Rat in Japan, Rat Resource and Research Center transgenic Live Animals; Cryopreserved Embryo (as of 2018-07-16) Development RRID:RRRC_00301 2304212 F344-RGD1563503Tn(sb-T2/Bart3)2.313Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 6th intron of RGD1563503. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) RGD1563503Tn(sb-T2/Bart3)2.313Mcwi 2304198 17 21066144 21067040 1 - by flanking markers 17 17584757 17585688 1 - by flanking markers 17 15526295 15527253 1 - by flanking markers RRID:RRRC_00453 2304213 F344-P3h3Tn(sb-T2/Bart3)2.310Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Leprel2 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) P3h3Tn(sb-T2/Bart3)2.310Mcwi 2304195 4 160964297 160978321 1 - by flanking markers 4 224377005 224392881 1 - by flanking markers 4 157359331 157375186 1 - by flanking markers 4 157646238 157662035 1 - by flanking markers RRID:RRRC_00433 2304214 W-Tg(CAG-ABO*B)2Jmsk This transgenic strain expresses the transferase B of the ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase ) driven by the CAG promoter established at Jichi Medical School. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Hematology Abo3 628609 RRID:RGD_2304214 2304215 F344-Tg(XPO1)1Hik F344/DuCrj Tg rat inoculated with human crm1 genome (BAC) National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo; Cryopreserved Sperm Cancer; Infectious RRID:RGD_2304215 2304221 WTC-swh/Kyo The rat showed abnormal hair texture and mammary gland hypoplasia which occurred in the WTC.ZI-Atrnzi colony at the National Cancer Center Research Institute in 1998. After elimination of zi allele, this strain has been maintained by sib mating and transferred to Kyoto Univ. in April 2002. In 2011, Kuramoto et al. (RGD:14398762) identified a missense mutation in the Edaradd gene. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2020-12-11) Dermatology EdaraddswhKyo 14398765 17 67056373 67143933 1 - by flanking markers 17 92462305 92503399 1 - by flanking markers 17 90802280 90843476 1 - by flanking markers 17 85866629 85910612 1 - by flanking markers RRID:RGD_2304221 2304222 WIAR/Iar Inbred Wistar-Imamichi Strain developed by the depositor. This strain was established by inbreeding of Wistar-Imamichi rats by sib-mating. Strain characteristic is same as that of Wistar-Imamichi. (Nov 6, 2009) National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-04-21) Metabolism; Development RRID:RGD_2304222 2304241 F344-Tg(CXCR4)1Hik Transgenic rat developed by microinjection of a human CXCR4: chemokine (C-X-C motif) receptor 4, containing BAC clone into F344/DuCrj. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo; Cryopreserved Sperm Infectious CXCR4 732176 RRID:RGD_2304241 2304242 WTC-Kcnq1dfkKyo Rats with abnormal behaviors such as head-tossing, drawing back, stepping back, and circling were discovered in the N12F10 generation of a WTC.ZI-Atrnzi congenic strain at the Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, in 1999. The WTC-Kcnq1dfk/Kyo rat is a mutant for circling behavior. although the Atrnzi allele of WTC.ZI-Atrnzi congenic rats was eliminated, the circling behavior remained. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2017-04-05) Otorhinology; Internal Organ Kcnq1|Kcnq1dfk 621503|12802344 1 203383401 203803687 1 - by flanking markers 1 223154713 223490458 1 - by flanking markers 1 216293087 216630339 1 - by flanking markers 1 198291711 198624683 1 - by flanking markers RRID:RGD_2304242 2304277 SHRSP.WKY-(D1Rat36-D1Rat106)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension 1 128874534 139471673 1 - by flanking markers 1 136045631 146282094 1 - by flanking markers 1 135022396 145354344 1 - by flanking markers 1 127453884 137184926 1 - by flanking markers RRID:RGD_2304277 2304278 DA-Tg(Alb-HSVtk)5Jmsk This strain expresses HSVtk (herpes simplex virus thymidine kinase) liver-specific driven by mouse albumin enhancer/promoter established at Jichi Medical School. Administration of injection ganciclovir (GCV) in these transgenic rats causes hepatitis. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Development RRID:RGD_2304278 2304279 W-Tg(MT2A-Myc)1Ys This transgenic rat is expressing the rat c-myc gene under the control of the human metallothionein II A promoter, established at the YS Institute, Inc. (present: PhoenixBio Co., Ltd.). National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Reproduction; Development Myc 3130 RRID:RGD_2304279 2304280 SHR/Shi Developed by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension RRID:RGD_2304280 2304281 SERC/Kyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Neurobiology RRID:RGD_2304281 2304282 IEW/Ihr mutant of Ihara epileptic rat. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo Neurobiology; Ophthalmology RRID:RGD_2304282 2304283 SHRSP.WKY-(D1Mgh5-D1Wox18)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension 1 78134304 94626661 1 - by flanking markers 1 80946174 101198506 1 - by flanking markers 1 79689548 100133395 1 - by flanking markers 1 78430536 94644553 1 - by flanking markers RRID:RGD_2304283 2304284 SHRSP.WKY-(D1Mgh5-D1Rat116)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension 1 78134304 218467340 1 - by flanking markers 1 80946174 239429964 1 - by flanking markers 1 79689548 232297227 1 - by flanking markers 1 78430536 212458660 1 - by flanking markers RRID:RGD_2304284 2304285 BDIX/NemOda This strain was maintained in Germany and was transferred to Japan by Dr. Tanaka of Aichi Cancer Center. Thereafter, this strain was transferred to Research Institute of Environmental Medicine, Nagoya University in 1973 and to Department of Agricultural, Nagoya University in 1992. National BioResource Project for the Rat in Japan inbred Unknown Cancer RRID:RGD_2304285 2304286 DMYC/Kyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan coisogenic Cryopreserved Sperm RRID:RGD_2304286 2304287 ACI.F344-(D16Rat17-D16Rat15)/Nkg F344 rats are susceptible and ACI rats are resistant to PhIP(2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)-induced ACF formation (Nagao, 1998). Targeting on susceptible gene for colon tumor on rat chromosome 16 (Nakagama, 1999), this congenic strain was established by backcrossing F344/Jcl, as a donor strain, and ACI/NJcl, as a recipient strain. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cancer RRID:RGD_2304287 2304288 ACI.BUF-(D20Img2-D20Rat5)/Ncc Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Unknown Cancer 20 18411845 18411969 1 - by flanking markers 20 21025611 21025734 1 - by flanking markers 20 18872150 18872273 1 - by flanking markers 20 17617832 17617956 1 - by flanking markers RRID:RGD_2304288 2304289 SHRSP.WKY-(D1Mgh5-D1Rat349)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension 1 78134304 130788777 1 - by flanking markers 1 80946174 137735636 1 - by flanking markers 1 79689548 136742994 1 - by flanking markers 1 78430536 78430678 1 - by flanking markers RRID:RGD_2304289 2304290 BUF.ACI-(D20Img2-D20Rat5)/Ncc Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Unknown Cancer 20 18411845 18411969 1 - by flanking markers 20 21025611 21025734 1 - by flanking markers 20 18872150 18872273 1 - by flanking markers 20 17617832 17617956 1 - by flanking markers RRID:RGD_2304290 2304291 LEW-Tg(CAG-EGFP)1Ys This transgenic strain contains the enhanced green fluorescent protein (EGFP) gene ubiquitously driven by CAG promoter. National BioResource Project for the Rat in Japan transgenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Development RRID:RGD_2304291 2304292 LEW-Tg((ROSA)26Sor-luc)21Jmsk This strain expresses luciferase ubiquitously driven by the gene trap ROSA 26 promoter established at Jichi Medical School. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo (as of 2017-08-08) Development RRID:RGD_2304292 2304293 F344.LEC-xhs1/1Nrs LEC rats which had high X-ray susceptibility were backcrossed to F344. In every generation, highly X-ray susceptible rats were selected with the radiation susceptibility assay National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm RRID:RGD_2304293 2304294 MPOD/Kyo Myeloperoxidase deficient rat was detected in Std:Wistar rats which purchased Japan SLC, Inc. in 2001. The causative gene is inherited as an autosomal recessive trait. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Cancer; Immunology RRID:RGD_2304294 2304295 SHRSP.WKY-(Igf1r-D1Rat36)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension Igf1r 2869 1 122704976 128874670 1 - by flanking markers 1 129985761 136045766 1 - by flanking markers 1 128924921 135022531 1 - by flanking markers 1 121549839 127454022 1 - by flanking markers RRID:RGD_2304295 2304296 KB/Oda Maintained by crossing heterozygotes of the albino locus (segregating inbred strain). National BioResource Project for the Rat in Japan segregating_inbred Cryopreserved Embryo RRID:RGD_2304296 2304297 TM.KDP-Cblb/Nyo Homozygous Cblb rats are usually infertile in both sexes and are therefore maintained by crossing heterozygous individuals (segregating inbred strain). National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Immunology Cblb 620535 11 49690402 49856762 1 - by flanking markers 11 54218260 54383403 1 - by flanking markers 11 51037383 51202761 1 - by flanking markers 11 48589878 48756940 1 - by flanking markers RRID:RGD_2304297 2304298 SD-Tg(Tuba1a-EYFP)Okn This strain expresses the enhanced yellow fluorescent protein (YGFP) neuron-specific driven by the Tubulin, alpha 1A promoter. National BioResource Project for the Rat in Japan transgenic Unknown RRID:RGD_2304298 2304299 LEW-Tg(Alb-GFP)6Jmsk This strain expresses the green fluorescent protein (GFP) liver-specific driven by the Albumin promoter established at Jichi Medical School. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Development RRID:RGD_2304299 2304300 W-Tg(S100b-EGFP)Scell Developed by microinjecting the transgene into Wistar rats National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo; Cryopreserved Sperm Neurobiology; Metabolism RRID:RGD_2304300 2304301 SHRSP.WKY-(Slco3a1-D1Rat106)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension Slco3a1 620227 1 129580126 139471673 1 - by flanking markers 1 136793300 146282094 1 - by flanking markers 1 135790854 145354344 1 - by flanking markers 1 128115184 137184926 1 - by flanking markers RRID:RGD_2304301 2304302 SHRSP.WKY-(D1Rat44-D1Arb21)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension 1 153754139 187092492 1 - by flanking markers 1 167707459 206277202 1 - by flanking markers 1 161493758 199254774 1 - by flanking markers 1 150872626 182418476 1 - by flanking markers RRID:RGD_2304302 2304303 W-Tg(MT2A-Myc)2Ys This transgenic rat is expressing the rat c-myc gene under the control of the human metallothionein II A promoter, established at the YS Institute, Inc. (present: PhoenixBio Co., Ltd.). National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Reproduction; Development Myc 3130 RRID:RGD_2304303 2304304 SHRSP.WKY-(D1Rat209-D1Arb21)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension 1 187092235 187092492 1 - by flanking markers 1 206276946 206277202 1 - by flanking markers 1 142486986 199254774 1 - by flanking markers 1 134641522 182418476 1 - by flanking markers RRID:RGD_2304304 2304305 DOB/Oda This strain was derived from wild specimens of the Rattus norvegicus trapped at goat shed in Sitara-cho, Kita-shitara-gun, Aichi, Japan, 2000. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo RRID:RGD_2304305 2304306 BUF.ACI-(D20Img2-Cdkn1a)/Ncc Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Unknown Cancer Cdkn1a 69328 20 7376325 7386778 1 - by flanking markers 20 8592437 8602879 1 - by flanking markers 20 6348422 6358864 1 - by flanking markers 20 7149177 7159727 1 - by flanking markers RRID:RGD_2304306 2304307 ACI.BUF-(D20Img2-Cdkn1a)/Ncc Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Unknown Cancer Cdkn1a 69328 20 7376325 7386778 1 - by flanking markers 20 8592437 8602879 1 - by flanking markers 20 6348422 6358864 1 - by flanking markers 20 7149177 7159727 1 - by flanking markers RRID:RGD_2304307 2304308 ICR/Ihr A new rat strain has been developed, in which a spontaneous cataract occurs without exception at 3-4 months after birth and matures completely at 4-6 months of age, indicating that this strain possesses a maturity-onset cataract. National BioResource Project for the Rat in Japan inbred Live Animals (as of 2019-08-05) Neurobiology; Ophthalmology RRID:RGD_2304308 2304309 SHRSP.WKY-(D1Mgh5-D1Rat106)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension 1 78134304 139471673 1 - by flanking markers 1 80946174 146282094 1 - by flanking markers 1 79689548 145354344 1 - by flanking markers 1 78430536 137184926 1 - by flanking markers RRID:RGD_2304309 2304310 SD-Tg(Nes/Hspa1b-EGFP)Okn This strain expresses green fluorescent protein (GFP) neural-specific driven by Nestin enhancer and Hspa1b promoter. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo; Cryopreserved Sperm Neurobiology RRID:RGD_2304310 2304311 LEW-Tg((ROSA26)Sor-lacZ)44JmskRrrc This strain expresses LacZ ubiquitously driven by the gene trap ROSA26 promoter established at Jichi Medical School. National BioResource Project for the Rat in Japan, Rat Resource and Research Center transgenic Cryopreserved Embryo (as of 2017-08-08) Development RRID:RRRC_00298 2304312 SHRSP.WKY-(D1Mgh5-D1Rat36)(D1Rat44-D1Arb21)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2304312 2304313 SHRSP.WKY-(D1Mgh5-D1Rat178)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension 1 78134304 85128763 1 - by flanking markers 1 80946174 89601109 1 - by flanking markers 1 79689548 79689689 1 - by flanking markers 1 78430536 78430678 1 - by flanking markers RRID:RGD_2304313 2304314 BDIX.Cg-Tal/NemOda Mating among heterozygoutes or between heterozygoute and normal individuals (segregating inbred strain). National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Osteosis RRID:RGD_2304314 2304315 SHRSP.WKY-(Calca-D1Arb21)/IzmTkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension Calca 2254 1 172686168 187092492 1 - by flanking markers 1 191158061 206277202 1 - by flanking markers 1 184184018 199254774 1 - by flanking markers 1 168878212 182418476 1 - by flanking markers RRID:RGD_2304315 2304316 F344.LEC-xhs1/2Nrs LEC rats which had high X-ray susceptibility were backcrossed to F344. In every generation, highly X-ray susceptible rats were selected with the radiation susceptibility assay National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm RRID:RGD_2304316 2304329 WKY/Ezo Deposited by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo Cardio Hypertension RRID:RGD_2304329 2304330 SD-Tg(HRAS)128Ncc This strain is carrying three copies of the human c-Ha-ras proto-oncogene, including its own promoter region. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2021-04-30) Cancer RRID:RGD_2304330 2304331 F344-Tg(CCR5)1Hik Deposited by the DEPOSITOR National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo; Cryopreserved Sperm Infectious RRID:RGD_2304331 2304332 HER/Wkmt Developed by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Live Animals Neurobiology RRID:RGD_2304332 2305934 F344-Spta1Tn(sb-T2/Bart3)2.315Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 48th intron of the Spta1 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Spta1Tn(sb-T2/Bart3)2.315Mcwi 2305932 13 89951924 90028592 1 - by flanking markers 13 96782387 96860327 1 - by flanking markers 13 92264231 92340091 1 - by flanking markers 13 86203504 86279371 1 - by flanking markers RRID:RRRC_00439 2305935 F344-Rtn4Tn(sb-T2/Bart3)2.316Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Rtn4 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Rtn4Tn(sb-T2/Bart3)2.316Mcwi 2305933 14 110725089 110772578 1 - by flanking markers 14 113792257 113839936 1 - by flanking markers 14 114126931 114174459 1 - by flanking markers 14 103450074 103497687 1 - by flanking markers RRID:RRRC_00476 2305939 SHRSP.WKY-(D9Mit6-D9Rat83)/Tkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2305939 2305940 SHRSP-Chr 7WKY/Tkyo Chromosome 7 from WKY is introgressed into the genomic background of SHRSP National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2305940 2305941 SHR-Chr 15WKY/Tkyo Chromosome 15 from WKY is introgressed into the genomic background of SHR National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2305941 2305942 SHR-Chr 3WKY/Tkyo Chromosome 3 from WKY is introgressed into the genomic background of SHR National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2305942 2305943 SHRSP-Chr 15WKY/Tkyo Chromosome 15 from WKY is introgressed into the genomic background of SHRSP National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2305943 2305944 SHRSP-Chr 4WKY/Tkyo Chromosome 4 from WKY is introgressed into the genomic background of SHRSP National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2305944 2305945 SHRSP-Chr 13WKY/Tkyo Chromosome 13 from WKY is introgressed into the genomic background of SHRSP National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2305945 2305946 SHR-Chr 1WKY/Tkyo Chromosome 1 from WKY is introgressed into the genomic background of SHR National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2305946 2305947 SHR-Chr 19WKY/Tkyo Chromosome 19 from WKY is introgressed into the genomic background of SHR National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2305947 2305948 SHRSP.WKY-(D8Rat77-D8Rat16)(D8Tkyo10)/Tkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2305948 2305949 SHRSP-Chr 1WKY/Tkyo Chromosome 1 from WKY is introgressed into the genomic background of SHRSP National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2305949 2305966 SHR.SHRSP-(D1Rat93-D1Rat269)/Izm Developed by the DEPOSITOR National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm Diabetes Obesity 1 63990899 126292805 1 - by flanking markers 1 63244295 133485967 1 - by flanking markers 1 64252881 132448306 1 - by flanking markers 1 65677942 124977364 1 - by flanking markers RRID:RGD_2305966 2305967 SHR.SHRSP-(D18Rat73-D18Rat11)/Izm Developed by the DEPOSITOR National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm Diabetes Obesity 18 52290789 71692408 1 - by flanking markers 18 50804228 69942605 1 - by flanking markers 18 51609032 70803264 1 - by flanking markers 18 49999958 68414117 1 - by flanking markers RRID:RGD_2305967 2305968 SHRSP.WKY-(D1Wox18-D1Rat39)/Izm Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity 1 94626541 125983558 1 - by flanking markers 1 101198387 133172336 1 - by flanking markers 1 100133276 132134441 1 - by flanking markers 1 94644435 124668572 1 - by flanking markers RRID:RGD_2305968 2305969 SHRSP.WKY-(D1Mgh5-D1Rat178)/Izm Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity 1 78134304 85128763 1 - by flanking markers 1 80946174 89601109 1 - by flanking markers 1 79689548 79689689 1 - by flanking markers 1 78430536 78430678 1 - by flanking markers RRID:RGD_2305969 2305970 DA-Tg(Alb-TTR*V30M)7Jmsk This is the strain expresses human Amyloidogenic transthyretin (ATTR) V30M driven by the mouse albumin enhancer/promoter, established at Jichi Medical School. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Development RRID:RGD_2305970 2305971 SHRSP.SHR-(D18Rat73-D18Rat11)/Izm Developed by the DEPOSITOR National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm Diabetes Obesity 18 52290789 71692408 1 - by flanking markers 18 50804228 69942605 1 - by flanking markers 18 51609032 70803264 1 - by flanking markers 18 49999958 68414117 1 - by flanking markers RRID:RGD_2305971 2305972 WKY.SHRSP-(D1Wox29-D1Arb21)(D9Mit6-D9Wox4)(Bcl2-D13Mgh7)/Izm Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2305972 2305973 SHRSP.SHR-(D1Rat93-D1Rat269)/Izm Developed by the DEPOSITOR National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm Diabetes Obesity 1 63990899 126292805 1 - by flanking markers 1 63244295 133485967 1 - by flanking markers 1 64252881 132448306 1 - by flanking markers 1 65677942 124977364 1 - by flanking markers RRID:RGD_2305973 2305974 WKY.SHRSP-(D1Wox29-D1Arb21)(D9Mit6-D9Wox4)/Izm Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2305974 2305975 SHRSP.WKY-(D1Mgh5-D1Wox18)/Izm Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity 1 78134304 94626661 1 - by flanking markers 1 80946174 101198506 1 - by flanking markers 1 79689548 100133395 1 - by flanking markers 1 78430536 94644553 1 - by flanking markers RRID:RGD_2305975 2305976 DA-Tg(Alb-TTR*V30M)9Jmsk This is the strain expresses human Amyloidogenic transthyretin (ATTR) V30M driven by the mouse albumin enhancer/promoter, established at Jichi Medical School. National BioResource Project for the Rat in Japan, Rat Resource & Research Center transgenic Cryopreserved Embryo Development RRID:RRRC_00339 2305977 ACI.F344-(D16Rat12-D16Mco2)/Nkg F344 rats are susceptible and ACI rats are resistant to PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)-induced ACF (aberrant crypt foci) formation (Nagao, 1998). This congenic strain was established using 'speed congenic' method by backcrossing (F344/JclxACI/NJcl)F1 onto ACI/NJcl, followed by intercrossing in N8 generation. Thereafter this strain is maintained by crossing homozygous individuals. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cancer 16 350121 67547357 1 - by flanking markers 16 1084304 67099528 1 - by flanking markers 16 1090054 1090164 1 - by flanking markers 16 380245 380356 1 - by flanking markers RRID:RGD_2305977 2305978 LEW-Tg((ROSA)26Sor-DsRed*)7Jmsk This strain expresses DsRed monomer ubiquitously driven by the gene trap ROSA 26 promoter, established at Jichi Medical School. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo (as of 2017-08-08) Development RRID:RGD_2305978 2305979 WKY.SHRSP-(D1Wox29-D1Arb21)(Bcl2-D13Mgh7)/Izm Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2305979 2305987 F344.OLETF-(D7Mgh16-D7Wox46)/Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 96491967 113050225 1 - by flanking markers 7 100584458 116158165 1 - by flanking markers 7 100004559 116255796 1 - by flanking markers 7 91256311 106845450 1 - by flanking markers RRID:RGD_2305987 2305988 (F344.OLETF-(D14Rat23-D14Rat12)(D14Rat8-D14Rat26)/2Tj x F344.Cg-Leprfa(D7Mgh16-D7Mgh20))F1 Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2305988 2305989 (F344.OLETF-(D14Rat23-D14Rat12)(D14Rat8-D14Rat26)/2Tj x F344.Z-Leprfa/Tj)F1 Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2305989 2305990 F344.OLETF-(D14Rat23-D14Rat23)(D14Rat8-D14Rat12)/2Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2305990 2305991 (F344.OLETF-(D7Mgh16-D7Mgh20)/Tj X F344.OLETF-(D8Rat54-D8Mgh17)/2Tj)F1 Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2305991 2305992 F344.OLETF-(D7Mit16-D7Mgh20)/Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 120745845 120746007 1 - by flanking markers 7 123587556 123587717 1 - by flanking markers 7 123602837 123602998 1 - by flanking markers 7 113886156 113886318 1 - by flanking markers RRID:RGD_2305992 2305993 F344.OLETF-(D14Rat23)(D14Rat12)/2Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2305993 2305994 F344.OLETF-(D14Rat23-D14Rat23)(D14Rat8-D14Rat12)/1Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Unknown Diabetes Obesity RRID:RGD_2305994 2305995 F344.OLETF-(D7Got130-D7Mgh20)/Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2305995 2305996 F344.Cg-Leprfa(D7Rat18-D7Mit2)(D14Rat23-D14Rat12)/Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2305996 2305997 (F344.OLETF-(D7Mgh16-D7Mgh20)(D14Rat23-D14Rat12)/2Tj x F344.OLETF-(D8Rat54-D8Mgh17)/2Tj)F1 Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2305997 2305998 F344.Cg-Leprfa(D8Rat54-D8Mgh17)/Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 8 19796514 73102155 1 - by flanking markers 8 21850030 79245063 1 - by flanking markers 8 74917593 80840067 1 - by flanking markers 8 69349194 69349344 1 - by flanking markers RRID:RGD_2305998 2305999 F344.OLETF-(D7Mgh16-D7Rat70)/Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 96491967 117397170 1 - by flanking markers 7 100584458 120641361 1 - by flanking markers 7 100004559 120648531 1 - by flanking markers 7 91256311 110979877 1 - by flanking markers RRID:RGD_2305999 2306000 F344.OLETF-(D7Rat70-D7Mgh20)/Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 117396947 117397170 1 - by flanking markers 7 120641139 120641361 1 - by flanking markers 7 120648309 120648531 1 - by flanking markers 7 110979654 110979877 1 - by flanking markers RRID:RGD_2306000 2306001 F344.OLETF-(D7Rat176-D7Mgh20)/Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 111200727 111200952 1 - by flanking markers 7 114641525 114641749 1 - by flanking markers 7 114708083 114708307 1 - by flanking markers 7 105399233 105399458 1 - by flanking markers RRID:RGD_2306001 2306002 F344.OLETF-(D14Rat23)(D14Rat12)/1Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2306002 2306003 F344.OLETF-(D7Wox46-D7Mgh20)/Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 113050053 113050225 1 - by flanking markers 7 116157993 116158165 1 - by flanking markers 7 116255624 116255796 1 - by flanking markers 7 106845277 106845450 1 - by flanking markers RRID:RGD_2306003 2306004 F344.OLETF-(D7Mgh16-D7Mit16)/Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 96491967 120746007 1 - by flanking markers 7 100584458 123587717 1 - by flanking markers 7 100004559 123602998 1 - by flanking markers 7 91256311 113886318 1 - by flanking markers RRID:RGD_2306004 2306013 F344.OLETF-(D14Rat8-D14Rat26)/2Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 14 32584630 70077314 1 - by flanking markers 14 32389647 69559504 1 - by flanking markers 14 32593926 69517234 1 - by flanking markers 14 30320092 65026991 1 - by flanking markers RRID:RGD_2306013 2306014 F344.OLETF-(D8Rat54-D8Mgh17)/2Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 8 19796514 73102155 1 - by flanking markers 8 21850030 79245063 1 - by flanking markers 8 74917593 80840067 1 - by flanking markers 8 69349194 69349344 1 - by flanking markers RRID:RGD_2306014 2306015 F344.OLETF-(D12Wox5-D12Rat21)/2Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 12 43801711 43801909 1 - by flanking markers 12 17721341 50319569 1 - by flanking markers 12 15714609 48536609 1 - by flanking markers 12 13635523 42767729 1 - by flanking markers RRID:RGD_2306015 2306016 F344.OLETF-(D11Mgh4-D11Mgh1)/2Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 11 61504311 84560241 1 - by flanking markers 11 65784365 89808503 1 - by flanking markers 11 62653194 86714631 1 - by flanking markers 11 59802622 82566702 1 - by flanking markers RRID:RGD_2306016 2306017 (F344.OLETF-(D8Rat54-D8Mgh17)/2Tj x F344.Cg-Leprfa(D14Rat23-D14Rat12))F1 Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2306017 2306018 F344.OLETF-(D9Mgh8-D9Mit2)/2Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 9 33374546 63705951 1 - by flanking markers 9 40808491 70797404 1 - by flanking markers 9 41139089 71771476 1 - by flanking markers 9 36840385 66437242 1 - by flanking markers RRID:RGD_2306018 2306019 F344.OLETF-(D1Mit20-D1Mgh26)/2Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 1 94356875 176616212 1 - by flanking markers 1 100372156 194998184 1 - by flanking markers 1 188051098 188051234 1 - by flanking markers 1 172711200 172711337 1 - by flanking markers RRID:RGD_2306019 2306020 (F344.OLETF-(D8Rat54-D8Mgh17)/2Tj x F344.Cg-Leprfa(D7Mgh16-D7Mgh20)(D14Rat23-D14Rat12))F1 Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2306020 2306021 SHR-Chr 2WKY/Tkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity; Cardio Hypertension RRID:RGD_2306021 2306022 KCI/Kyo Rats showing abnormal behaviors characterized by constant circling movements were found in the F3 generation of Crl:CD(SD) rats purchased from Charles River Laboratory Japan in 2003. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Neurobiology Pcdh15 1590969 20 14507804 15240479 1 - by flanking markers 20 17138580 19021206 1 - by flanking markers 20 14952213 15334745 1 - by flanking markers 20 13997094 15496446 1 - by flanking markers RRID:RGD_2306022 2306023 F344-Tg(CCNT1)1Hik Developed by the DEPOSITOR National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Infectious CCNT1 1322457 RRID:RGD_2306023 2306024 FOK/Ncu Furuyama rat These are resistant to hot environment. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_2306024 2306025 WMN/Nrs Developed by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo Cancer; Metabolism RRID:RGD_2306025 2306026 F344.OLETF-(D16Wox4-D16Rat13)/2Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 16 51452966 77968799 1 - by flanking markers 16 51050772 77759249 1 - by flanking markers 16 51339600 78172206 1 - by flanking markers 16 48143982 73187298 1 - by flanking markers RRID:RGD_2306026 2306027 WM/Nrs Developed by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo Cancer; Metabolism RRID:RGD_2306027 2306028 F344.OLETF-(D14Rat23-D14Rat12)(D14Rat8-D14Rat26)/2Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2306028 2306029 (F344.OLETF-(D8Rat54-D8Mgh17)/2Tj x F344.Cg-Leprfa(D7Mgh16-D7Mgh20))F1 Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2306029 2306030 F344.OLETF-(D7Mgh16-D7Mgh20)(D14Rat8-D14Rat26)/2Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2306030 2306033 SHR.Cg-Leprcp/NDmcr Nonsense mutation of leptin receptor gene in the obese spontaneously hypertensive Koletsky rat was transferred to SHR/N strain at NIH. This strain has been maintained at Disease Model Cooperative Research Association (DMCRA) scince 1999. National BioResource Project for the Rat in Japan congenic Live Animals Diabetes Obesity; Cardio Hypertension Leprcp 11570565 RRID:RGD_2306033 2306034 NER.F344-(D1Mgh6-D1Rat132)(D5Rat100-D5Rat234)/Kyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology RRID:RGD_2306034 2306035 F344.NER-(D1Mgh6-D1Rat73)(D5Mgh4-D5Rat36)/Kyo This double congenic strain was established by crossing F344.NER-(D1Mgh6-D1Rat73)/Kyo and F344.NER-(D5Mgh4-D5Rat36)/Kyo National BioResource Project for the Rat in Japan congenic Live Animals Neurobiology RRID:RGD_2306035 2306036 F344-Apcm1Kyo F344/NSlc rats that have an induced mutation in the Apc (S2523X) gene; Established by ENU mutagenesis (gene-driven). National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm (as of 2017-03-14) Cancer Apc|Apcm1Kyo 2123|12792252 18 26732147 26790383 1 - by flanking markers 18 26725560 26820837 1 - by flanking markers 18 27011710 27106323 1 - by flanking markers 18 25828558 25925511 1 - by flanking markers RRID:RGD_2306036 2306037 F344-Tg(CD4)1Hik Developed by the DEPOSITOR National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Infectious RRID:RGD_2306037 2306041 F344-Scn1am2Kyo Established by ENU mutagenesis. A point mutation in Scn1a gene. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Neurobiology Scn1am2Kyo 12792284 3 48238528 48364143 1 - by flanking markers 3 59016641 59135580 1 - by flanking markers 3 52388811 52533365 1 - by flanking markers 3 50952790 51071804 1 - by flanking markers RRID:RGD_2306041 2306042 F344-Scn1am1Kyo Established by ENU mutagenesis. A missense mutant N1417H (4246A>G)was identified in the model. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm (as of 2017-05-04) Neurobiology Scn1am1Kyo 12792283 3 48238528 48364143 1 - by flanking markers 3 59016641 59135580 1 - by flanking markers 3 52388811 52533365 1 - by flanking markers 3 50952790 51071804 1 - by flanking markers RRID:RGD_2306042 2306043 SHR/4Dmcr Developed by the DEPOSITOR, this is one of the SHR substrains, CL line, which shows lower blood pressure National BioResource Project for the Rat in Japan inbred Live Animals Cardio Hypertension Cd36 2301 RRID:RGD_2306043 2306044 SHRSP/3Dmcr Developed by the DEPOSITOR, this is one of the SHRSP substrains, A4 line National BioResource Project for the Rat in Japan inbred Live Animals Cardio Hypertension Cd36 2301 RRID:RGD_2306044 2306045 SHR/2Dmcr Developed by the DEPOSITOR, one of the SHR substrains from B2 line National BioResource Project for the Rat in Japan inbred Live Animals Cardio Hypertension Cd36 2301 RRID:RGD_2306045 2306046 W-Tg(CAG-EGFP)3Ys This transgenic strain contains the enhanced green fluorescent protein (EGFP) gene ubiquitously driven by CAG promoter. National BioResource Project for the Rat in Japan transgenic Live Animals; Cryopreserved Embryo RRID:RGD_2306046 2306047 W-Tg(Gnrh1-EGFP)Nphy This transgenic strain contains the enhanced green fluorescent protein (EGFP) gene driven by gonadotropin-releasing hormone 1 (Gnrh1) promoter. EGFP fluorescence is observed only in Gnrh1-immunoreactive neurons, approximately one third of which has strong EGFP fluorescence. National BioResource Project for the Rat in Japan transgenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Gnrh1 2720 RRID:RGD_2306047 2306048 SHR/3Dmcr Developed by the DEPOSITOR, this is one of the SHR substrains, CH line, which shows high blood pressure National BioResource Project for the Rat in Japan inbred Live Animals Cardio Hypertension Cd36 2301 RRID:RGD_2306048 2306049 SHRSP/4Dmcr Developed by the DEPOSITOR, this is one of the SHRSP substrains, CT line, which shows cardiac thrombosis National BioResource Project for the Rat in Japan inbred Live Animals Cardio Hypertension Cd36 2301 RRID:RGD_2306049 2306050 SHRSP/5Dmcr Developed by the DEPOSITOR, This is one of the SHRSP substrains, ALR line, which is prone to arteiolipidosis National BioResource Project for the Rat in Japan inbred Live Animals Cardio Hypertension Cd36 2301 RRID:RGD_2306050 2306051 SHRSP/2Dmcr Developed by the DEPOSITOR, this is one of the SHRSP substrains, A1sb line National BioResource Project for the Rat in Japan inbred Live Animals Cardio Hypertension Cd36 2301 RRID:RGD_2306051 2306058 LEC.W-Tg(CAG-Zfml)30Ncms/Ncms Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm RRID:RGD_2306058 2306059 DA.Cg-Foxn1rnu Lystbg/Slc Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Immunology; Hematology Foxn1|Lyst 3970|621837 RRID:RGD_2306059 2306060 LEC.W-Tg(CAG-Zfml)26Ncms/Ncms Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm RRID:RGD_2306060 2306061 ACI.BUF-Pur1, Thym2/Mna The proteinuria-susceptible gene, Pur1 (on chr.13) and the thymus enlargement, Ten2 (Thym2) (on chr.13) loci of BUF/Mna were transferred to ACI by backcrossing from Matsuyama et al. Congenic rats are established in 2002. National BioResource Project for the Rat in Japan congenic Unknown Metabolism RRID:RGD_2306061 2306062 W-Tg(Per1-luc)1Oa Developed by the DEPOSITOR National BioResource Project for the Rat in Japan, Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00273 2306063 LEC.W-Tg(CAG-Zfml)21Ncms/Ncms Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm RRID:RGD_2306063 2306064 MPR/Iar Developed by the DEPOSITOR National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Metabolism; Osteosis Arsb|ArsbMPR 2158|12792967 2 24067560 24223821 1 - by flanking markers 2 42559079 42717753 1 - by flanking markers 2 23385154 23543028 1 - by flanking markers 2 25002210 25162675 1 - by flanking markers RRID:RGD_2306064 2306070 WIC-Tg(Wap-GH1)1Mni Ikeda developed transgenic rats carrying the human growth hormone (GH1) driven by murine Wap promoter, originated from Wistar-Imamichi (Ikeda, 1994). Two lines of this transgenic strain were established named Line 1: characterized by relatively high level of serum Gh1 (high line, NBRPNo.0490), and Line 2: relatively low level of serum Gh1 (low line, NBRPNo.0491). National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2017-04-21) Diabetes Obesity; Metabolism RRID:RGD_2306070 2306071 F344-Tg(CAG-EGFP)Ncco Transgenic rat: CAG promoter, Enhanced Green Fluorescent Protein gene, microinjection method National BioResource Project for the Rat in Japan transgenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity; Cancer; Metabolism RRID:RGD_2306071 2306072 ACI.F344-(D16Nkg74)/Nkg A sub congenic strain of ACI/N.F344-(D16Rat12-D16Mco2)/Nkg National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cancer RRID:RGD_2306072 2306073 WIC-Tg(Wap-GH1)2Mni Ikeda developed transgenic rats carrying the human growth hormone (GH1) driven by murine Wap promoter, originated from Wistar-Imamichi (Ikeda, 1994). Two lines of this transgenic strain were established named Line 1: characterized by relatively high level of serum Gh1 (high line, NBRPNo.0490), and Line 2: relatively low level of serum Gh1 (low line, NBRPNo.0491). National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2017-04-21) Diabetes Obesity; Metabolism RRID:RGD_2306073 2306076 ACI.F344-(D16Nkg9-D16Nkg38)/Nkg This congenic strain was established by backcrossing ACI.F344-(D16Rat12-D16Mco2)Nkg onto ACI/NJcl, followed by intercrossing in N8 generation, thereafter maintained by crossing homozygous individuals. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cancer RRID:RGD_2306076 2306077 ACI.F344-(D16Rat64-D16Nkg105)/Nkg This congenic strain was established by backcrossing ACI.F344-(D16Rat12-D16Mco2)/Nkg onto ACI/NJcl, followed by intercrossing in N6 generation, thereafter maintained by sib mating. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cancer 16 59398206 59398647 1 - by flanking markers 16 58966446 58966664 1 - by flanking markers 16 59285775 59285993 1 - by flanking markers 16 55711087 55711306 1 - by flanking markers RRID:RGD_2306077 2306078 KFRS4A/Kyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Neurobiology; Behavior RRID:RGD_2306078 2306079 ACI.F344-(D16Nkg87-D16Nkg105)/Nkg This congenic strain was established by backcrossing ACI.F344-(D16Rat64-D16Nkg105)/Nkg onto ACI/NJcl, followed by intercrossing in N9 generation. maintained by crossing homozygous individuals. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cancer RRID:RGD_2306079 2306085 TCR/Ibu Toyoda Circling Rat A male rat shows circling behavior was found in the Wistar rats purchaced from Kiwa Laboratory Animals Co., Ltd. in 2007. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Neurobiology; Behavior RRID:RGD_2306085 2306089 ACI.BUF-(D7Wox16-D7Rat69)/Mna The thymoma susceptible locus of rat-1, Tsr1 (on Chr.7) was transferred from BUF/Mna to ACI/NMs by repeated backcrossing. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cancer 7 64611964 113044228 1 - by flanking markers 7 67991394 116151991 1 - by flanking markers 7 67801457 67801690 1 - by flanking markers 7 60460452 60460686 1 - by flanking markers RRID:RGD_2306089 2306090 ExHC/Ta Exogenously hypercholesterolemic rat Developed by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Live Animals (as of 2017-04-19) Metabolism RRID:RGD_2306090 2306098 ACI.F344-(D16Nkg30-D16Mgh6)/Nkg This congenic strain was established by backcrossing ACI.F344-(D16Rat12-D16Mco2)/Nkg onto ACI/NJcl, followed by intercrossing in N9 generation, thereafter maintained by crossing homozygous individuals. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm 16 49150370 49150515 1 - by flanking markers 16 48766016 48766115 1 - by flanking markers 16 49051407 49051506 1 - by flanking markers 16 45868397 45868497 1 - by flanking markers RRID:RGD_2306098 2306099 SHR.WKY-(D15Tkyo3-D15Rat68)/Tkyo This congenic strain was established from WKY/Izm purchased from Japan SLC, Inc. and SHR/Izm at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 15 62521452 62521592 1 - by flanking markers 15 67139660 67139799 1 - by flanking markers 15 63498932 63499071 1 - by flanking markers 15 56484420 56484560 1 - by flanking markers RRID:RGD_2306099 2306100 SHR.WKY-(D3Tkyo7-D3Rat1)/Tkyo This congenic strain was established from WKY/Izm purchased from Japan SLC, Inc. and SHR/Izm at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 3 99858951 170016653 1 - by flanking markers 3 112038782 180128021 1 - by flanking markers 3 105465332 176418101 1 - by flanking markers 3 100769917 168026850 1 - by flanking markers RRID:RGD_2306100 2306101 LEC.BN-(D4Mgh16-D4Rat233)/Hkv Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm 4 61646674 108329449 1 - by flanking markers 4 61427427 170105737 1 - by flanking markers 4 61708103 105384025 1 - by flanking markers 4 62933269 107032773 1 - by flanking markers RRID:RGD_2306101 2306102 BN.LEC-(D4Rat128-D4Rat106)/Hkv Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm 4 79189959 117887968 1 - by flanking markers 4 145335315 179959894 1 - by flanking markers 4 80666353 115372927 1 - by flanking markers 4 79986873 116179656 1 - by flanking markers RRID:RGD_2306102 2306103 SHRSP/Sums Developed by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo RRID:RGD_2306103 2306104 BN.LEC-(D4Rat184-D4Rat238)/Hkv Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm 4 120665583 142160377 1 - by flanking markers 4 182854846 203361566 1 - by flanking markers 4 118283596 138891201 1 - by flanking markers 4 118928273 139725596 1 - by flanking markers RRID:RGD_2306104 2306105 BN.LEC-(D4Rat128-D4Rat238)/Hkv Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm 4 79189959 142160377 1 - by flanking markers 4 145335315 203361566 1 - by flanking markers 4 80666353 138891201 1 - by flanking markers 4 79986873 139725596 1 - by flanking markers RRID:RGD_2306105 2306106 CLX/Ta Circling behavior linked to the X-chromosome (CLX) Developed by the DEPOSITOR National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo Behavior RRID:RGD_2306106 2306107 SD-Tg(Sp6)58Tj The transgenic construct carrying rat Sp6 coding region was introduced to Slc:SD. Established at YS institute (PhoenixBio) in 2006 and introduced to the University of Tokushima. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2017-08-22) Dentistry; Development Sp6 1306768 RRID:RGD_2306107 2306108 SHR.WKY-(D3Mit9-D3Wox16)/Tkyo This congenic strain was established from WKY/Izm purchased from Japan SLC, Inc. and SHR/Izm at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 3 26674018 89245110 1 - by flanking markers 3 39535971 100667805 1 - by flanking markers 3 34394121 94028641 1 - by flanking markers 3 30356773 90477342 1 - by flanking markers RRID:RGD_2306108 2306109 SHR.WKY-(D3Mgh6-D3Rat1)/Tkyo This congenic strain was established from WKY/Izm purchased from Japan SLC, Inc. and SHR/Izm at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 3 50522618 170016653 1 - by flanking markers 3 61249840 180128021 1 - by flanking markers 3 54630948 176418101 1 - by flanking markers 3 53184593 168026850 1 - by flanking markers RRID:RGD_2306109 2306110 IER/Sums Developed by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo Neurobiology RRID:RGD_2306110 2306111 LEC.BN-(D4Mgh16-D4Rat233)(D4Rat271-D4Rat238)/Hkv Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm RRID:RGD_2306111 2306112 ZDF-LeprfaCrlCrlj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Embryo Diabetes Obesity Lepr 3001 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RGD_2306112 2306113 SD-Tg(Sp6)6Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Dentistry; Development Sp6 1306768 RRID:RGD_2306113 2306114 SHR.WKY-(D3Mgh16-D3Rat110)/Tkyo This congenic strain was established from WKY/Izm purchased from Japan SLC, Inc. and SHR/Izm at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 3 6373335 42729760 1 - by flanking markers 3 11361699 53824856 1 - by flanking markers 3 6000748 47155284 1 - by flanking markers 3 10778704 10778823 1 - by flanking markers RRID:RGD_2306114 2306115 SHR.WKY-(D3Mgh16-D3Rat166)/Tkyo This congenic strain was established from WKY/Izm purchased from Japan SLC, Inc. and SHR/Izm at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 3 6373335 101359980 1 - by flanking markers 3 11361699 113470358 1 - by flanking markers 3 6000748 106900596 1 - by flanking markers 3 10778704 102200699 1 - by flanking markers RRID:RGD_2306115 2306116 SD-Tg(Sp6)5Tj The transgenic construct carrying rat Sp6 cording region was introduced to Slc:SD. Established at YS institute (PhoenixBio) in 2006 and introduced to the University of Tokushima. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Dentistry; Development Sp6 1306768 RRID:RGD_2306116 2306117 ACI.F344-(D16Nkg9-D16Nkg27)/Nkg This congenic strain was established by backcrossing ACI.F344-(D16Rat12-D16Mco2/Nkg onto ACI/NJcl, followed by intercrossing in N9 generation, thereafter maintained by crossing homozygous individuals. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm RRID:RGD_2306117 2306118 SHR.WKY-(D15Rat95-D15Rat106)/Tkyo This congenic strain was established from WKY/Izm purchased from Japan SLC, Inc. and SHR/Izm at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 15 69469532 106177917 1 - by flanking markers 15 74166614 109944957 1 - by flanking markers 15 70559420 106550657 1 - by flanking markers 15 63180675 98288169 1 - by flanking markers RRID:RGD_2306118 2306119 F344-Tg(CD4,CCNT1)1Hik Developed by the DEPOSITOR National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Infectious RRID:RGD_2306119 2306120 SHR.WKY-(D4Wox27-D4Rat15)/Tkyo This congenic strain was established from WKY/Izm purchased from Japan SLC, Inc. and SHR/Izm at the Research Institute International Medical Center of Japan in 2001. The rats which have the heterozygous consomic segment were established in 2004, and were bred homozygous in 2005. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity; Cardio Hypertension 4 460493 47890193 1 - by flanking markers 4 3096322 48448808 1 - by flanking markers 4 3044017 48656399 1 - by flanking markers 4 5218294 50119996 1 - by flanking markers RRID:RGD_2306120 2306276 F344-Exoc4Tn(sb-T2/Bart3)2.317Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 7th intron of the Exoc4 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Exoc4Tn(sb-T2/Bart3)2.317Mcwi 2306273 4 60406942 61284294 1 - by flanking markers 4 60287465 61081401 1 - by flanking markers 4 60549128 61358305 1 - by flanking markers 4 61807706 62584316 1 - by flanking markers RRID:RRRC_00456 2306277 F344-Gng12Tn(sb-T2/Bart3)2.320Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Gng12 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Gng12Tn(sb-T2/Bart3)2.320Mcwi 2306274 4 96622363 96624479 1 - by flanking markers 4 162420268 162549350 1 - by flanking markers 4 97634925 97763478 1 - by flanking markers 4 96011118 96134767 1 - by flanking markers RRID:RRRC_00454 2306278 F344-AW915325Tn(sb-T2/Bart3)2.319Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the EST AW915325. PhysGen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-31) AW915325Tn(sb-T2/Bart3)2.319Mcwi 2306272 RRID:RRRC_00448 2306279 F344-Diaph3Tn(sb-T2/Bart3)2.318Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Diaph3 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Diaph3Tn(sb-T2/Bart3)2.318Mcwi 2306275 15 68905784 69267707 1 - by flanking markers 15 73538942 74007617 1 - by flanking markers 15 69928507 70400077 1 - by flanking markers 15 62543375 63013060 1 - by flanking markers RRID:RRRC_00446 2306529 BBDR.BBDP-(D4Rhw11-D4Rhw10)/Rhw Parental strain BBDR.BBDP-(D4Rhw17-ss99306861)(D4Rhw11-D4Rhw10)/Rhw were backcrossed to BBDR/Rhw, carefully DNA between D4Rhw17-ss99306861 was removed giving the desired congenic Department of Medicine, University of Washington, Seattle, Washington congenic Unknown 4 75808584 77809321 1 - by flanking markers 4 142052025 144005977 1 - by flanking markers 4 77380565 79326833 1 - by flanking markers 4 76721312 78654798 1 - by flanking markers RRID:RGD_2306529 2306532 BBDR.F344-(D4Rat27-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw Congenic substrains developed by crossing BBDR.F344-(D4Rat153-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw to BBDR/Rhw producing animals which were intercrossed to produce F2 lymphonic rats that had reduced F344 DNA Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_2306532 2306533 BBDR.F344-(D4Rat102-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/2Rhw Congenic substrains generated by intercrossing BBDR.F344-(D4Rat253-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw and BBDR.F344-(D4Got33-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RRRC_00469 2306534 BBDR.F344-(D4Rat102-D4Rat27),BBDP-(D4Rhw11-D4Rhw10)/Rhw Congenic substrains identified in F2 crosses of BBDR.F344-(D4Rat153-D4Rat27),BBDP-(D4Rhw6-D4Rat62)/Rhw and BBDR/Rhw with BBDR.BBDP-(D4Rhw11-D4Rhw10)/Rhw Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_2306534 2306535 BBDR.F344-(D4Rat253-D4Rat27),BBDP-(D4Rhw11-D4Rhw10)/Rhw Congenic substrains identified in F2 crosses of BBDR.F344-(D4Rat153-D4Rat27),BBDP-(D4Rhw6-D4Rat62)/Rhw and BBDR/Rhw with BBDR.BBDP-(D4Rhw11-D4Rhw10)/Rhw Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_2306535 2306536 BBDR.F344-(D4Arb11-D4Rat27),BBDP-(D4Rhw11-D4Rhw10)/Rhw Congenic substrains generated by intercrossing male BBDR.F344-(D4Rat153-D4Rat27),BBDP-(D4Rhw11-D4Rhw10)/Rhw and female BBDR/Rhw Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_2306536 2306537 BBDR.F344-(D4Rat102-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/1Rhw Congenic substrains generated by intercrossing BBDR.F344-(D4Rat253-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw and BBDR.F344-(D4Got33-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_2306537 2306538 BBDR.F344-(D4Rat153-D4Rat27),BBDP-(D4Rhw11-D4Rhw10)/Rhw Congenic substrains generated by intercrossing BBDR.F344-(D4Rat153-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw and BBDR.BBDP-(D4Rhw11-D4Rhw10)/Rhw to reduce the proximal end of F344 DNA while retaining the Gimap5 mutation Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_2306538 2306539 BBDR.F344-(D4Rat102-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/3Rhw Congenic substrains developed by crossing BBDR.F344-(D4Rat153-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw to BBDR/Rhw producing animals which were intercrossed to produce F2 lymphonic rats that had reduced F344 DNA Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_2306539 2306540 BBDR.F344-(D4Got33-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw Congenic substrains developed by crossing BBDR.F344-(D4Rat153-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw to BBDR/Rhw producing animals which were intercrossed to produce F2 lymphonic rats that had reduced F344 DNA Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_2306540 2306541 BBDR.F344-(D4Rat153-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw BBDR.BBDP-(D4Mit6-D4Mit7)/Rhw were intercrossed with F344 giving a recombination proximal to Gimap1 fragment. Whole-genome scan, STS and SSLP analyses were done to determine the region introgressed Department of Medicine, University of Washington, Seattle, Washington, Rat Resource and Research Center congenic Unknown RRID:RRRC_00457 2306542 BBDR.F344-(D4Rat253-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw Congenic substrains developed by crossing BBDR.F344-(D4Rat153-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw to BBDR/Rhw producing animals which were intercrossed to produce F2 lymphonic rats that had reduced F344 DNA Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_2306542 2306543 BBDR.F344-(D4Got59-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw BBDR.BBDP-(D4Mit6-D4Mit7)/Rhw were intercrossed with F344 giving a recombination proximal to Gimap1 fragment. Whole-genome scan, STS and SSLP analyses were done to determine the region introgressed Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_2306543 2306544 BBDR.F344-(D4Rat26-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw Congenic substrains developed by crossing BBDR.F344-(D4Rat153-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw to BBDR/Rhw producing animals which were intercrossed to produce F2 lymphonic rats that had reduced F344 DNA Department of Medicine, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_2306544 2306709 BBDR.BBDP-(D4Mit6-D4Mit7)/3Rhw This congenic strain was developed by cyclic cross-intercross breeding using diabetic prone and diabetic resistant BB rats. (DP x DR)F1 x DR cross intercross breeding was used to generate F2 lymphopenic rats. These were then genotyped for both the flanking markers of the Gimap5 gene. Department of Medicine, University of Washington, Seattle, Washington congenic Unknown 4 75732943 75733127 1 - by flanking markers 4 141978848 141979031 1 - by flanking markers 4 77307388 79562753 1 - by flanking markers 4 76647384 78886189 1 - by flanking markers RRID:RGD_2306709 2306710 F344-LmlnTn(sb-T2/Bart3)2.322Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 12th intron of the Lmln gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) LmlnTn(sb-T2/Bart3)2.322Mcwi 2306701 11 69481117 69547133 1 - by flanking markers 11 73980288 74048100 1 - by flanking markers 11 70895141 70963121 1 - by flanking markers 11 67656241 67725889 1 - by flanking markers RRID:RRRC_00447 2306711 F344-FM117003Tn(sb-T2/Bart3)2.321McwiRrrc this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb PhysGen, Rat Resource & Research Center mutant Cryopreserved Sperm FM117003Tn(sb-T2/Bart3)2.321Mcwi 2306703 RRID:RRRC_00475 2306712 BBDR.BBDP-(D4Mit6-D4Mit7)/2Rhw This congenic strain was developed by cyclic cross-intercross breeding using diabetic prone and diabetic resistant BB rats. (DP x DR)F1 x DR cross intercross breeding was used to generate F2 lymphopenic rats. These were then genotyped for both the flanking markers of the Gimap5 gene. Department of Medicine, University of Washington, Seattle, Washington congenic Unknown 4 75732943 75733127 1 - by flanking markers 4 141978848 141979031 1 - by flanking markers 4 77307388 79562753 1 - by flanking markers 4 76647384 78886189 1 - by flanking markers RRID:RGD_2306712 2306717 BBDP/WorSunn These originated from the Worcester colony from the rats that were sent from Ottawa to Worcester in 1977. Now maintained at University of Toronto, Canada. Department of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada, Rat Resource and Research Center inbred Cryopreserved Sperm; Cryorecovery (as of 2018-11-12) RRID:RRRC_00787 2306784 Kini:DA,PVG-G12 Two breeding pairs from inbred DA/Han and PVG/OlaHsd that share the RT1a MHC haplotype were bred to create F1 generation, 7 couples of F1 with DA/Han and PVG/OlaHsd females founders generated F2. F3 generation originated from breeding 50 random couples Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden advanced_intercross_line Unknown RRID:RGD_2306784 2306815 SS.SR-(D7Rat67-D7Mco7)/Jr Congenic substrain developed by crossing SS.SR-(D7Uia1-D7Mco7)/Jr to SS/Jr to produce F1 which were intercrossed and genotyped Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 7 111506104 113014423 1 - by flanking markers 7 114961803 116100169 1 - by flanking markers 7 115041287 115041463 1 - by flanking markers 7 105699315 105699492 1 - by flanking markers RRID:RGD_2306815 2306816 SS.SR-(D7Mco19-D7Mco7)/Jr Congenic substrain developed by crossing SS.SR-(D7Uia1-D7Mco7)/Jr to SS/Jr to produce F1 which were intercrossed and genotyped Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 7 112800232 113014423 1 - by flanking markers 7 115828017 116100169 1 - by flanking markers 7 115922628 115922885 1 - by flanking markers 7 106571501 106571759 1 - by flanking markers RRID:RGD_2306816 2306817 SS.SR-(D7Uia1-D7Mco19)/Jr Congenic substrain developed by crossing SS.SR-(D7Uia1-D7Mco7)/Jr to SS/Jr to produce F1 which were intercrossed and genotyped Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 7 108875615 112800489 1 - by flanking markers 7 112367543 115828274 1 - by flanking markers 7 112429186 115922885 1 - by flanking markers 7 103146217 106571759 1 - by flanking markers RRID:RGD_2306817 2306818 SS.SR-(D7Rat131-D7Mco7)/Jr Congenic substrain developed by crossing SS.SR-(D7Uia1-D7Mco7)/Jr to SS/Jr to produce F1 which were intercrossed and genotyped Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 7 111882387 113014423 1 - by flanking markers 7 115334997 116100169 1 - by flanking markers 7 115421039 115421228 1 - by flanking markers 7 106074002 106074194 1 - by flanking markers RRID:RGD_2306818 2306819 SS.SR-(D7Uia1-D7Rat131)/Jr Congenic substrain developed by crossing SS.SR-(D7Uia1-D7Mco7)/Jr to SS/Jr to produce F1 which were intercrossed and genotyped Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 7 108875615 111882577 1 - by flanking markers 7 112367543 115335186 1 - by flanking markers 7 112429186 115421228 1 - by flanking markers 7 103146217 106074194 1 - by flanking markers RRID:RGD_2306819 2306820 SS.SR-(D3Arb14-D3Mco36)/Mco SS.SR-(D3Mco19-D3Mco5)/Jr rats were crossed with SS to yield F1, these heterozygous rats were intercrossed to obtain F2 which were screened to identify the SR-rat derived region, these were then crossed with SS to duplicate the recombinant chromosome Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 3 171009566 171009778 1 - by flanking markers 3 181074759 181074971 1 - by flanking markers 3 177366448 177366660 1 - by flanking markers 3 168974481 168974694 1 - by flanking markers RRID:RGD_2306820 2306823 SS.SR-(D3Arb14-D3Mco36)(D7Mco19-D7Mco7)/Mco SS.SR-(D3Arb14-D3Mco36)/Mco were crossed with SS.SR-(D7Mco19-D7Mco7)/Jr and then F1 rats were backcrossed with SS.SR-(D3Arb14-D3Mco36)/Mco, animals heterozygous for chr 7 and homozygous for chr 3 were crossed and the resulting progeny homozygous for both segments were bred Medical College of Ohio, Toledo, Ohio, USA congenic Unknown RRID:RGD_2306823 2306840 E3.DA-(D4Wox22-D4Got132)(D12Wox5-D12Rat26)/Rhd This congenic strain was obtained by the conventional backcross breeding to the parental strain with positive selection of microsatellite markers Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown RRID:RGD_2306840 2306841 E3.DA-(D12Wox5-D12Rat26)/Rhd This congenic strain was obtained by the conventional backcross breeding to the parental strain with positive selection of microsatellite markers Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown 12 23845554 23845733 1 - by flanking markers 12 17721341 27718984 1 - by flanking markers 12 15714609 25711626 1 - by flanking markers 12 13635523 22692658 1 - by flanking markers RRID:RGD_2306841 2306842 E3.DA-(D20Rat45-D20Rat47)/Rhd This congenic strain was obtained by the conventional backcross breeding to the parental strain with positive selection of microsatellite markers Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown 6;20 133455626;1616332 133455718;5447494 1 - by flanking markers;1 - by flanking markers 20 4059279 8810333 1 - by flanking markers 20 2018654 6567533 1 - by flanking markers 20 1527842 5304690 1 - by flanking markers RRID:RGD_2306842 2306874 F344-IntuTn(sb-T2/Bart3)2.324Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 4th intron of the Intu gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) IntuTn(sb-T2/Bart3)2.324Mcwi 2306873 2 127564813 127639564 1 - by flanking markers 2 147063971 147216092 1 - by flanking markers 2 127459089 127521327 1 - by flanking markers 2 123600972 123685331 1 - by flanking markers RRID:RRRC_00441 2306875 F344-FaslgTn(sb-T2/Bart3)2.325Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Faslg gene. PhysGen mutant Extinct (as of 2017-01-26) FaslgTn(sb-T2/Bart3)2.325Mcwi 2306872 13 77472950 77480210 1 - by flanking markers 13 84590119 84605900 1 - by flanking markers 13 79696811 79717581 1 - by flanking markers 13 74151519 74172760 1 - by flanking markers RRID:RGD_2306875 2306892 SHR.BN-(D2Rat114-D2Rat123)/Jk Backcross marker-assisted method was used to fix the BN fragment onto SHR genome, once selection was done using markers, male and female were crossed to get homozygous animals Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil. Genetica congenic Unknown 2 36432989 112326568 1 - by flanking markers 2 55361257 131889716 1 - by flanking markers 2 36245223 112175725 1 - by flanking markers 2 109366814 109366971 1 - by flanking markers RRID:RGD_2306892 2306893 SHR.BN-(D16Rat87-D16Mgh1)/Jk Backcross marker-assisted method was used to fix the BN fragment onto SHR genome, once selection was done using markers, male and female were crossed to get homozygous animals Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil. Genetica congenic Unknown 16 3464719 46137590 1 - by flanking markers 16 4082652 45651269 1 - by flanking markers 16 4136355 45905331 1 - by flanking markers 16 3380150 43025077 1 - by flanking markers RRID:RGD_2306893 2306894 SHR.BN-(D4Rat33-D4Rat54)/Jk Backcross marker-assisted method was used to fix the BN fragment onto SHR genome, once selection was done using markers, male and female were crossed to get homozygous animals Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil. Genetica congenic Unknown 4 80205349 121829076 1 - by flanking markers 4 146540904 184799673 1 - by flanking markers 4 81874073 119546974 1 - by flanking markers 4 81006124 120102625 1 - by flanking markers RRID:RGD_2306894 2306895 SHR.BN-(D2Rat226-D2Rat294)/Jk Backcross marker-assisted method was used to fix the BN fragment onto SHR genome, once selection was done using markers, male and female were crossed to get homozygous animals Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil. Genetica congenic Unknown 2 170338294 236153712 1 - by flanking markers 2 197020226 262435073 1 - by flanking markers 2 177680772 243901375 1 - by flanking markers 2 164073756 227146641 1 - by flanking markers RRID:RGD_2306895 2306961 RLA/Verh Roman low avoidance Bignami selected for low avoidance conditioning with light as a conditioned stimulus and electric shock as the unconditioned stimulus,these are now at Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Belgium Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Belgium inbred Unknown RRID:RGD_2306961 2306962 RHA/Verh Roman high avoidance Bignami selected for high avoidance conditioning with light as a conditioned stimulus and electric shock as the unconditioned stimulus,these are now at Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Belgium Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Belgium inbred Unknown RRID:RGD_2306962 2307077 HXB4/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307077 2307078 HXB27/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307078 2307079 HXB3/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307079 2307080 HXB20/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307080 2307081 HXB31/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307081 2307082 HXB18/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307082 2307083 HXB10/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307083 2307084 HXB24/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307084 2307085 HXB17/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307085 2307086 HXB7/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307086 2307087 SHR.BN-(D18Rat32-D18Rat12)/Ipcv A segment of chr 18 from BN was introgressed into the SHR background Czech Academy of Sciences, Prague, Czech Republic congenic Unknown RRID:RGD_2307087 2307088 HXB22/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307088 2307089 HXB29/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307089 2307090 SHR.BN10/Ipcv A segment of chr 10 from BN was introgressed into the SHR background Czech Academy of Sciences, Prague, Czech Republic congenic Unknown RRID:RGD_2307090 2307091 HXB13/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307091 2307092 HXB14/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307092 2307093 HXB23/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307093 2307094 HXB1/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307094 2307095 HXB15/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307095 2307096 HXB2/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307096 2307097 HXB21/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307097 2307098 HXB25/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307098 2307099 HXB5/Ipcv Derived from founder strains SHR/OlaIpcv and BN-Lx/Cub Czech Academy of Sciences, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307099 2307115 BXH5/Cub Derived from founder strains BN-Lx/Cub and SHR/OlaIpcv Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307115 2307116 PXO3-2/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307116 2307117 PXO5-2/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307117 2307118 PXO9/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307118 2307119 PXO7-1/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307119 2307120 PXO7-2/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307120 2307121 BXH2/Cub Derived from founder strains BN-Lx/Cub and SHR/OlaIpcv Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307121 2307122 PXO8-1/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307122 2307123 BXH13/Cub Derived from founder strains BN-Lx/Cub and SHR/OlaIpcv Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307123 2307124 BXH10/Cub Derived from founder strains BN-Lx/Cub and SHR/OlaIpcv Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307124 2307125 PXO6-2/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307125 2307126 BXH8/Cub Derived from founder strains BN-Lx/Cub and SHR/OlaIpcv Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307126 2307127 BXH11/Cub Derived from founder strains BN-Lx/Cub and SHR/OlaIpcv Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307127 2307128 PXO5-1/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307128 2307129 BXH9/Cub Derived from founder strains BN-Lx/Cub and SHR/OlaIpcv Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307129 2307130 PXO6-3/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307130 2307131 PXO8-2/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307131 2307132 PXO10/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307132 2307133 BXH12-2/Cub Derived from founder strains BN-Lx/Cub and SHR/OlaIpcv Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307133 2307134 BXH3/Cub Derived from founder strains BN-Lx/Cub and SHR/OlaIpcv Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307134 2307135 PXO4/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307135 2307136 BXH6/Cub Derived from founder strains BN-Lx/Cub and SHR/OlaIpcv Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307136 2307137 PXO6-1/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307137 2307138 PXO1/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307138 2307139 BXH12-1/Cub Derived from founder strains BN-Lx/Cub and SHR/OlaIpcv Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307139 2307155 SHR/1NCrl To Charles River from NIH in 1973 at F32. MRC Clinical Sciences Centre, College School of Medicine, London, UK inbred Unknown RRID:RGD_2307155 2307156 DA/ZtmKini Substrain of DA, to Hannover after 1965, now at Stockholm, Sweden. Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden inbred Unknown RRID:RGD_2307156 2307157 PVG.1AV1/Kini Originally derived by Dr. Hans J. Hendrich at Versuchstierzucht, Hannover, Germany, now at Stockholm, Sweden. Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden congenic Unknown RRID:RGD_2307157 2307159 SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb SHRSP were crossed with SHRSR to give heterozygous F2 animals, these were backcrossed and heterozygotes with desired segment of interest selected and backcrossed to fix the allele of interest Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown Mt1-ps1|Klk1c12 3118|1303192 1 94355758 185690396 1 - by flanking markers 1 100371040 204941832 1 - by flanking markers 1 99298965 197963072 1 - by flanking markers 1 94378103 181133270 1 - by flanking markers RRID:RGD_2307159 2307160 SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb SHRSP were crossed with SHRSR to give heterozygous F2 animals, these were backcrossed and heterozygotes with desired segment of interest selected and backcrossed to fix the allele of interest Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown Klk1c12 1303192 1 94355758 146971983 1 - by flanking markers 1 100371040 162692800 1 - by flanking markers 1 99298965 156446783 1 - by flanking markers 1 94378103 144267916 1 - by flanking markers RRID:RGD_2307160 2307161 SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb SHRSP were crossed with SHRSR to give heterozygous F2 animals, these were backcrossed and heterozygotes with desired segment of interest selected and backcrossed to fix the allele of interest Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown Mt1-ps1 3118 1 135467526 185690396 1 - by flanking markers 1 142390027 204941832 1 - by flanking markers 1 141429089 197963072 1 - by flanking markers 1 133634986 181133270 1 - by flanking markers RRID:RGD_2307161 2307166 SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb SHRSP were crossed with SHRSR to give heterozygous F2 animals, these were backcrossed and heterozygotes with desired segment of interest selected and backcrossed to fix the allele of interest Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown Mt1-ps1|Klk1c12 3118|1303192 1 94355758 185690396 1 - by flanking markers 1 100371040 204941832 1 - by flanking markers 1 99298965 197963072 1 - by flanking markers 1 94378103 181133270 1 - by flanking markers RRID:RGD_2307166 2307167 SHRSP.SHRSR-(Klk1-D1Mit3)/Bbb SHRSP were crossed with SHRSR to give heterozygous F2 animals, these were backcrossed and heterozygotes with desired segment of interest selected and backcrossed to fix the allele of interest Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown Klk1c12 1303192 1 94355758 146971983 1 - by flanking markers 1 100371040 162692800 1 - by flanking markers 1 99298965 156446783 1 - by flanking markers 1 94378103 144267916 1 - by flanking markers RRID:RGD_2307167 2307168 SHRSR/Bbb Spontaneously Hypertensive Rat, Stroke Resistant This SHRSP colony as obtained from the original Japanese stock from Okamoto and Aoki in 1974 and is propagated by strict inbreeding. Now this colony is maintained at Max-Delbruck-Center for Molecular Medicine, Berlin, Germany. Max-Delbruck-Center for Molecular Medicine, Berlin, Germany inbred Unknown RRID:RGD_2307168 2307169 SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb SHRSP were crossed with SHRSR to give heterozygous F2 animals, these were backcrossed and heterozygotes with desired segment of interest selected and backcrossed to fix the allele of interest Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown Mt1-ps1 3118 1 135467526 185690396 1 - by flanking markers 1 142390027 204941832 1 - by flanking markers 1 141429089 197963072 1 - by flanking markers 1 133634986 181133270 1 - by flanking markers RRID:RGD_2307169 2307298 BN/HanKini Substrain of BN derived from BN/Han (Dr. H.J. Hedrich, Hannover, Germany) Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden inbred Unknown RRID:RGD_2307298 2307299 ACI/ZtmKini substrain of ACI derived from ACI/Ztm Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden inbred Unknown RRID:RGD_2307299 2307300 LEW.1AV1/Kini Substrain of LEW.1AV1 Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown RRID:RGD_2307300 2307301 DA.LEW.RT1f-(D20Wox15-D20Wox13)/Rhd RT1f Haplotype on DA background, congenic strain was obtained by conventional backcross breeding to the parental DA/Ztm from LEW.1F/Ztm with positive selection of microsatellite markers Section for Medical Inflammation Research, Biomedical Center, Lund University, Sweden congenic Unknown 20 2790524 6695696 1 - by flanking markers 20 5249993 10234922 1 - by flanking markers 20 3151827 8034632 1 - by flanking markers 20 2646407 6515143 1 - by flanking markers RRID:RGD_2307301 2307317 MHS Milan Hypertensive Strain Outbred Wistar rats with brother x sister mating and selection for high systolic blood pressure Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy outbred Unknown RRID:RGD_2307317 2307318 BDIX/Ifz derived from Berlin-Druckrey strain BDIX Duisburg-Essen University Medical School, Essen, Germany inbred Unknown RRID:RGD_2307318 2307319 MNS/N Milan normotensive strain Wistar rats with brother x sister mating and selection for low systolic blood pressure as a normotensive control for MHS. Rat Resource and Research Center inbred Cryopreserved Embryo RRID:RRRC_00171 2307355 PXO3-1/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307355 2307356 PXO2/Cub Derived from polydactylous (P) SHR.Lx congenic strain and oligodactylous (O) BXH2 recombinant inbred strain. These are homozygous in the Lx allele. Charles University, Department of Biology, Prague, Czech Republic recombinant_inbred Unknown RRID:RGD_2307356 2307357 BDV/Ztm Developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. Zentralinstitut fur Versuchstierzucht, Hannover, Germany inbred Unknown RRID:RGD_2307357 2307358 LUDW/OlaHsd Ludwig Wistar stock to Ludwig Institute, Sutton.From Ludwig Institute to Harlan in 1979. Envigo inbred Cryorecovery RRID:RGD_2307358 2307359 BUF/SimRijHsd Developed by Heston in 1946 from a Buffalo Harlan Sprague Dawley, Inc., Indianapolis, IN inbred Unknown RRID:RGD_2307359 2307360 DA.BI.RT1i-(D20Rat42-D20Rat31)/Rhd RT1i Haplotype on DA background, congenic strain originates from BI, formerly B3 (extinct strain) and was produced at Zentralinstitut for Versuchstierzucht, Hannover, Germany). It has been maintained by conventional backcross breeding to the parental DA/Han. Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown 20 4582054 10410227 1 - by flanking markers 20 6265460 12972703 1 - by flanking markers 20 4186104 10800530 1 - by flanking markers 20 4459698 10078919 1 - by flanking markers RRID:RGD_2307360 2307441 F344-Cyyr1Tn(sb-T2/Bart3)2.328Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Cyyr1 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Cyyr1Tn(sb-T2/Bart3)2.328Mcwi 2307440 11 25036792 25157304 1 - by flanking markers 11 28591553 28702298 1 - by flanking markers 11 24967936 25078740 1 - by flanking markers 11 24557620 24664007 1 - by flanking markers RRID:RRRC_00452 2307442 F344-Robo1Tn(sb-T2/Bart3)2.327Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Robo1 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Robo1Tn(sb-T2/Bart3)2.327Mcwi 2307439 11 10784947 11720646 1 - by flanking markers 11 13314508 13808775 1 - by flanking markers 11 9079291 10146302 1 - by flanking markers 11 10580863 11621672 1 - by flanking markers RRID:RRRC_00451 2308816 Crl:WI(Han) Rederived by GlaxoWellcome from Han Wistar stock supplied by BRL (under structural changed to RCC). Transferred to Charles River UK in 1996. Transferred to Charles River in 1997 and rederived into isolator maintained Foundation Colony. IGS refers to animals bred using the Charles River International Genetic Standard system. Charles River Laboratories outbred Unknown RRID:RGD_2308816 2308851 Crl:OP(CD) Obese Prone Rats Developed from a line of Crl:CD(SD) rats. Two lines were developed from this outbred colony, the OP-CD(Obese Prone) and OR-CD (Obese Resistant). This model becomes obese when fed high-fat diets. Obesity develops despite having a fully functioning leptin receptor. The control for this model is the Crl:OR(CD). Charles River Laboratories outbred Unknown RRID:RGD_2308851 2308852 Crl:LE Long-Evans Rats Originated by Drs. Long and Evans in 1915 by crossing several Wistar white females with a wild gray male. To Charles River from Canadian Breeding Farm and Laboratories in 1978. Charles River Laboratories outbred Unknown RRID:RGD_2308852 2308853 Crl:OR(CD) Obese Resistant Rats Developed from a line of Crl:CD(SD) rats. Two lines were developed from this outbred colony, the OP-CD (Obese Prone) and OR-CD (Obese Resistant). This model does not become obese when fed high-fat diets. Charles River Laboratories outbred Unknown RRID:RGD_2308853 2308885 GK/CskCrljCrl The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. To Chugai Pharmaceutical Co. To Charles River Japan in 1995. To Charles River in 2006. Charles River Laboratories inbred Unknown RRID:RGD_2308885 2308886 SS/HsdMcwiCrl Inbred from a congenic control group of Dahl/SS rats (SS/JrHsd) obtained from Dr. Theodore Kurtz (UCSF, CA) which were originally derived from the Harlan SS/Jr colony. Maintained at the Medical College of Wisconsin since 1991, this strain has undergone considerable marker-selected breeding to eliminate residual heterozygosity and genetic contamination. To confirm homozygosity, the strain was tested with 200 microsatellite markers (genome-wide scan at 20cM) all of which were homozygous for all regions tested. (Cowley et al. 2000, Physiol. Genomics 2:107-115). To Charles River in 2001. Charles River Laboratories inbred Unknown RRID:RGD_2308886 2311049 SHROB/KolGmiCrl-Leprcp/Crl This mutation occurred in the laboratory of Dr. Simon Koletsky in 1969 at Case Western Reserve University School of Medicine. It was developed from a cross between a hypertensive female rat and a normotensive male Sprague Dawley rat. The colony was maintained as brother x sister matings in a closed colony at Case Western Reserve University School of Medicine since 1971. To Genetic Models, Inc. in 2000. To Charles River in 2001. Charles River Laboratories coisogenic Unknown Leprcp 11570565 RRID:RGD_2311049 2311051 SHRSP/A3NCrl Stroke Prone Rats The Spontaneously Hypertensive Stroke Prone Rat (SHRSP) was isolated from Wistar-Kyoto rats by Okamoto and Aoki in 1963. The A3 subline was transferred to the National Institutes of Health in 1975 from Yamori at generation F36. To Charles River in 2002. Charles River Laboratories inbred Unknown RRID:RGD_2311051 2311070 BUF/CrCrl Buffalo Rat Heston in 1946 from Buffalo stock of H. Morris. To NIH in 1951 at F10. To Charles River in 1998 from the National Cancer Institute Animal Production Program (Cr). Charles River Laboratories inbred Unknown RRID:RGD_2311070 2311071 ZDF-Leprfa/Crl A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974???75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. An inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001. Charles River Laboratories coisogenic Unknown Lepr 3001 RRID:RGD_2311071 2311072 FHH/EurMcwiCrl An outbred stock of fawn hooded rats was introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, when brother x sister mating was initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in expression of hypertension and proteinuria. The colony was transferred to Erasmus University in Rotterdam, The Netherlands, then to the Medical College of Wisconsin in the 1990s. To Charles River in 2001. Charles River Laboratories inbred Unknown RRID:RGD_2311072 2311073 NBL/CrCrl Bogden in the mid-1970s from Noble strain rats (brother x sister mated but not descended from a single pair, and therefore not necessarily isogenic). To National Cancer Institute Animal Production Program (Cr) in 1978. To Charles River in 1998. Charles River Laboratories inbred Unknown RRID:RGD_2311073 2311074 BDIX/CrCrl Druckrey from a cross between BDI and BDVIII with subsequent selection of brother-sister pairs for agouti coat color and dark, pigmented eyes. To Charles River in 1998 from the National Cancer Institute Animal Production Program (Cr). Charles River Laboratories inbred Unknown RRID:RGD_2311074 2311078 Crl:CD-Hrhr CD hairless rats This spontaneous mutation model was isolated from a Crl:CD(SD) colony in Charles River, Wilmington, MA in the late 1980s. Rederived in 1993 and subsequently transferred to Charles River, Raleigh, NC for barrier room production. The model does not exhibit the typical characteristics of hair growth and loss found in other hairless models. Specific genetic analysis to identify the mutation has not been undertaken. Histopathology has determined the model is euthymic. Charles River Laboratories outbred Unknown RRID:RGD_2311078 2311079 WF/CrCrl J. Furth in 1945 from a commercial Wistar stock in an attempt to develop a rat strain with a high incidence of leukemia. To Charles River in 1998 from the National Cancer Institute Animal Production Program (Cr). Charles River Laboratories inbred Unknown RRID:RGD_2311079 2311082 SS-Chr 13BN/McwiCrl Developed at the Medical College of Wisconsin. To Charles River in 2003. Charles River Laboratories consomic Unknown RRID:RGD_2311082 2311692 F344-Myo1dTn(sb-T2/Bart3)2.334Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 18th intron of the Myo1d gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Myo1dTn(sb-T2/Bart3)2.334Mcwi 2311691 10 68720729 68997721 1 - by flanking markers 10 67520649 67811744 1 - by flanking markers 10 67866939 68142864 1 - by flanking markers 10 65489153 65765812 1 - by flanking markers RRID:RRRC_00478 2311693 F344-Tmem22Tn(sb-T2/Bart3)2.332Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Tmem22 gene. PhysGen, Transposagen mutant Extinct (as of 2017-01-26) Tmem22Tn(sb-T2/Bart3)2.332Mcwi 2311689 8 105416072 105443969 1 - by flanking markers 8 108269643 108297339 1 - by flanking markers 8 108854134 108881519 1 - by flanking markers 8 101085576 101113366 1 - by flanking markers RRID:RGD_2311693 2311694 F344-Fam227aTn(sb-T2/Bart3)2.333Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the Fam227a gene. PhysGen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Fam227aTn(sb-T2/Bart3)2.333Mcwi 2311687 7 117441099 117469873 1 - by flanking markers 7 120839737 120881869 1 - by flanking markers 7 120846166 120891738 1 - by flanking markers 7 111174362 111216513 1 - by flanking markers RRID:RRRC_00484 2312352 LEW.1N These congenic rats carry the RTln haplotype on the LEW strain genetic background. Zentralinstitut fur Versuchstierzucht, Hannover, Germany congenic Unknown RRID:RGD_2312352 2312447 SD-Tg(Pmp22)Kan This transgenic strain was derived by pronuclear microinjection of fertilized SD rats with a 43 kb fragment containing Pmp22 gene which was isolated from mouse SV129 cosmid library Max Planck Institute for Experimental Medicine, Gottingen, Germany transgenic Unknown Pmp22 11125 RRID:RGD_2312447 2312466 Crl:LIS Lister Hooded Rat These rats have taken their names from the Lister Institute, where the stocks first originated. From Glaxo to Charles River UK in 1990 and again in 1996. To Charles River Geramny in 2007. Noted for its docility and good breeding performance. Charles River Laboratories outbred Unknown RRID:RGD_2312466 2312471 Crl:ZUC(Orl)-Leprfa The spontaneous mutation "obese" (Fatty) was found in the 13M rat stock of Sherman and Merck, by Doctor Lois Zucker, Harriet Bird Memorial Laboratory, Stow, Massachusetts 01775, USA, in 1961. The strain was introduced in Orleans at CSEAL, France in 1970; then transferred to Charles River France in 1991. Charles River Laboratories outbred Unknown Leprfa 13432153 RRID:RGD_2312471 2312472 Crl:WI(WU) Wistar Wu Rat Selection by H.H. Donalson at the Wistar-Institute, USA, at the begining of 19th century. To Glaxo-lab. in 1927, continued as inbred. To Nederlands-Institute voor Volksfoending in 1993, to Unilever, Vlaardingen in 1941 and Institut Centraale Proefdierenbedrijf TNO in 1958. Caesarean rederived in 1963. As an outbred to SAVO, Kiblegg in 1975. Caesarean rederived at Charles River in 1987. Charles River Laboratories outbred Unknown RRID:RGD_2312472 2312473 BDIX/OrlCrl BDIX Rats Rats selected in 1937 by H. Druckrey in Berlin from a strain of yellow coated, pink-eyed rats. It is part of a series of BD I to X strains produced at Max Planck Institute, Freiburg and was introduced to France in 1971 to the INSERM unit, Immunology Laboratory, Dijon where it was maintained in strict brother-sister inbreeding. Developed and studied by Dr. Ms. Martin, CNRS/CSEAL, Orleans who obtained it from Dijon in 1983. To Charles River France in 1991. Charles River Laboratories inbred Unknown RRID:RGD_2312473 2312474 Crl:OFA(SD) The original strain was composed in 1925 by Robert Worthington Dawley. Carworth Farms obtained it in 1955 and renamed it CFE (Carworth Farms Elias). Transferred to Charles River France in 1967, it then became known as OFA (Oncins France Strain A), in 1968. Charles River Laboratories outbred Unknown RRID:RGD_2312474 2312498 WAG/RijCrl WAG Rats A.L. Bacharach, Glaxo Labs., U.K., 1924, from a Wistar stock. To Harrington in 1964 at F83. To MBL-TNO in 1953, after that to REP Institutes TNO, Rijswijk. To Charles River Germany from REP Institutes TNO in 1993. Charles River Laboratories inbred Unknown RRID:RGD_2312498 2312499 Crl:NIH-Foxn1rnu Nude Rats The NIH nude rat was developed in 1979/80 through a series of matings involving 8 inbred rat strains. To Charles River USA from the NIH Animal Genetic Resources. Caesarian derived in 2001. This athymic model shows depleted cell populations in thymus-dependent areas of peripheral lymphoid organs. Charles River Laboratories outbred Unknown RRID:RGD_2312499 2312504 Crlj:WI Wistar Institute to Scientific Products Farm, Ltd to CRLUS(1975) to CRLJ(1981) Charles River Laboratories outbred Unknown RRID:RGD_2312504 2312511 WF/IcoCrl Wistar Rats Furth developed this strain at Roswell Park Memorial Institute, Buffalo, NY, USA in 1945 starting from a commercial colony of Wistar rats. Acquired by Charles River from the MIcrobiological Associates, Bethesda, Maryland, USA. Introduced to Charles River France in 1970. Charles River Laboratories inbred Unknown RRID:RGD_2312511 2312512 ZSF1-Leprfa Leprcp/Crl This hybrid rat is a cross between a ZDF female and a SHHF male rat. This model was developed at Genetic Models International, Indianapolis. To Charles River in 2001. Charles River Laboratories hybrid Unknown RRID:RGD_2312512 2312513 Crlj:DON Dr. Sato(1952) to Nippon Rat to CRLJ(1990) Charles River Laboratories outbred Unknown RRID:RGD_2312513 2312514 Crlj:LEC Hokkaido Univ.(1975) to Otsuka Pharma. (1988) to CRLJ (1991). Charles River Laboratories outbred Unknown RRID:RGD_2312514 2312518 Crlj:ZUC-Leprfa Zucker(1961) to Roche to CRLUS(1985) to CRLJ(2000) Charles River Laboratories outbred Unknown Leprfa 13432153 RRID:RGD_2312518 2312577 SHR.BN-(D18Rat99-D18Rat82)/Ipcv F2 rats from SHR x SHR.BN-(D18Rat113-D18Rat82)/Ipcv were genotyped and backcrossed with SHR/OlaIpcv and segment of interest fixed by intercrossing heterozygotes to get homozygosity Czech Academy of Sciences, Prague, Czech Republic congenic Unknown 18 31654683 73666623 1 - by flanking markers 18 32165265 72695235 1 - by flanking markers 18 32487692 73016546 1 - by flanking markers 18 30558524 70263868 1 - by flanking markers RRID:RGD_2312577 2312578 SHR.BN-(D18Rat82)/Ipcv F2 rats from SHR x SHR.BN-(D18Rat113-D18Rat82)/Ipcv were genotyped and backcrossed with SHR/OlaIpcv and segment of interest fixed by intercrossing heterozygotes to get homozygosity Czech Academy of Sciences, Prague, Czech Republic congenic Unknown 18 73666205 73666623 1 - by flanking markers 18 72695068 72695235 1 - by flanking markers 18 73016379 73016546 1 - by flanking markers 18 70263698 70263868 1 - by flanking markers RRID:RGD_2312578 2312579 SHR.BN-(D18Rat40-D18Rat82)/Ipcv F2 rats from SHR x SHR.BN-(D18Rat113-D18Rat82)/Ipcv were genotyped and backcrossed with SHR/OlaIpcv and segment of interest fixed by intercrossing heterozygotes to get homozygosity Czech Academy of Sciences, Prague, Czech Republic congenic Unknown 18 62106066 73666623 1 - by flanking markers 18 60695794 72695235 1 - by flanking markers 18 61499531 73016546 1 - by flanking markers 18 59330409 70263868 1 - by flanking markers RRID:RGD_2312579 2312580 SHR.BN-(D18Rat113-D18Rat82)/Ipcv SHR/OlaIpcv were crossed with BN/Crl, F1 animals were backcrossed with SHR/OlaIpcv and genotyped; heterozygotes with the region of interest were backcrossed with SHR/OlaIpcv and segment of interest fixed by intercrossing heterozygotes Czech Academy of Sciences, Prague, Czech Republic congenic Unknown 18 73666205 73666623 1 - by flanking markers 18 72695068 72695235 1 - by flanking markers 18 3719547 73016546 1 - by flanking markers 18 70263698 70263868 1 - by flanking markers RRID:RGD_2312580 2312609 MWF-Chr 8SHR/Rkb MWF/FubRkb male was crossed with female SHR/FubRkb to get F1 animals which in turn were backcrossed with female MWF/FubRkb and the desired consomic selected by marker assisted backcrossing Department of Clinical Pharmacology and Toxicology, Charite-Universitatsmedizin Berlin, Berlin, Germany consomic Unknown RRID:RGD_2312609 2312644 DA.WOKW-(D3Mit10-D3Rat189)/K A cross of DA/K and WOKW/K which resulted in a segment of chr 3 from WOKW/K introgressed in DA/K background Dept. of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany congenic Unknown 3 35797577 35797756 1 - by flanking markers 3 44863125 44863303 1 - by flanking markers 3 39773247 39773425 1 - by flanking markers 3 38710365 38710544 1 - by flanking markers RRID:RGD_2312644 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K A cross of DA/K and WOKW/K which resulted in a segment of chr 16 from WOKW/K introgressed in DA/K background Dept. of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany congenic Unknown 16 819225 63306215 1 - by flanking markers 16 1534408 62873174 1 - by flanking markers 16 1550187 63210301 1 - by flanking markers 16 832236 59492508 1 - by flanking markers RRID:RGD_2312645 2312646 DA.WOKW-(D5Mgh6-D5Mit5)/K A cross of DA/K and WOKW/K which resulted in a segment of chr 5 from WOKW/K introgressed in DA/K background Dept. of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany congenic Unknown 5 71814715 109163425 1 - by flanking markers 5 75334610 112058005 1 - by flanking markers 5 71154828 108092802 1 - by flanking markers 5 68984307 104251008 1 - by flanking markers RRID:RGD_2312646 2312647 DA.WOKW-(D3Mgh5-D3Rat1)/K A cross of DA/K and WOKW/K which resulted in a segment of chr 3 from WOKW/K introgressed in DA/K background Dept. of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany congenic Unknown 3 97523869 170016653 1 - by flanking markers 3 109733850 180128021 1 - by flanking markers 3 103141814 176418101 1 - by flanking markers 3 98535255 168026850 1 - by flanking markers RRID:RGD_2312647 2312648 DA.WOKW-(D10Mgh2-D10Rat4)/K A cross of DA/K and WOKW/K which resulted in a segment of chr 10 from WOKW/K introgressed in DA/K background Dept. of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany congenic Unknown 10 106422174 107033716 1 - by flanking markers 10 105533457 105533612 1 - by flanking markers 10 105875105 105875260 1 - by flanking markers 10 102134116 102134272 1 - by flanking markers RRID:RGD_2312648 2312733 BN-Chr 13SS Chr 18SS/Mcwi A cross of BN and SS strains which results in a BN genomic background with a SS chromosomes 13 and 18 introgressed PhysGen consomic Cryopreserved Sperm RRID:RGD_2312733 2313181 LEW.1WR1/WorBrm Obtained from Hanover Institute, Hanover, Germany in 1989; then maintained in a closed colony by sibling mating at Universtiy of Massachusetts, Worcester, MA then moved to Biomedical Research Models, Inc. Biomedical Research Models, Inc. congenic Unknown RRID:RGD_2313181 2313209 WF.ART2/Wor developed at the Universtiy of Massachusetts, Medical School Universtiy of Massachusetts, Worcester, MA congenic Unknown RRID:RGD_2313209 2313221 SHHF-Leprcp/Crl Developed by bx SHROB to SHR/N. 1983 from JE Miller, Searle, to McCune after 7th bx, she continued to inbreed to fix congestive heart failure trait. To GMI in 1994, to CR in 2001. Charles River Laboratories congenic Unknown Leprcp 11570565 RRID:RGD_2313221 2313222 BN/HsdMcwiCrl BN/NHsdMcwi colony directly from Medical College of Wisconsin by brother-sister mating then to Charles River Charles River Laboratories inbred Unknown RRID:RGD_2313222 2313231 LEWBNF1/Crl This hybrid rat is a cross between a LEW female and a BN male rat. Charles River Laboratories hybrid Unknown RRID:RGD_2313231 2313232 WFF344F1/Crl This hybrid rat is a cross between a WF female and a F344 male rat. Charles River Laboratories hybrid Unknown RRID:RGD_2313232 2313342 BN-Chr 17LH/Mav Chr 17 from LH/Mav was introgressed onto the genetic background of BN/NHsdMcwi and then genotyped Laboratoire de Physiologie, Lyon Cedex , France consomic Unknown RRID:RGD_2313342 2313343 LH-Chr 13BN/Mav Chr 13 from BN/NHsdMcwi was introgressed onto the genetic background of LH/Mav and then genotyped Laboratoire de Physiologie, Lyon Cedex , France consomic Unknown RRID:RGD_2313343 2313384 Wild/Nov These are wild-caught rats selected on the basis of level of tameness and defensive aggression at every generation since 1972 at Institute of Cytology and Genetics, Siberian Branch of the Academy of Sciences, Novosibirsk, Russia Institute of Cytology and Genetics, Siberian Branch of the Academy of Sciences, Novosibirsk, Russia wild Unknown RRID:RGD_2313384 2313463 F344-Ppfia2Tn(sb-T2/Bart3)2.339Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 5th intron of the Ppfia2 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Ppfia2Tn(sb-T2/Bart3)2.339Mcwi 2313459 7 45140154 45616620 1 - by flanking markers 7 48563521 49058116 1 - by flanking markers 7 48548932 49045852 1 - by flanking markers 7 41765716 42240104 1 - by flanking markers RRID:RRRC_00474 2313464 F344-LargeTn(sb-T2/Bart3)2.336Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 6th intron of the Large gene. PhysGen, Transposagen mutant Extinct (as of 2017-01-26) LargeTn(sb-T2/Bart3)2.336Mcwi 2313460 19 12043818 12497663 1 - by flanking markers 19 23595328 24054765 1 - by flanking markers 19 12481563 12945320 1 - by flanking markers 19 11603129 12048930 1 - by flanking markers RRID:RGD_2313464 2313465 F344-Pld5Tn(sb-T2/Bart3)2.340Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Pld5 gene. PhysGen, Transposagen, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Pld5Tn(sb-T2/Bart3)2.340Mcwi 2313462 13 91715000 92058036 1 - by flanking markers 13 98486317 98812030 1 - by flanking markers 13 94025696 94355219 1 - by flanking markers 13 87895694 88232868 1 - by flanking markers RRID:RRRC_00483 2313466 F344-Agbl4Tn(sb-T2/Bart3)2.337Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 6th intron of the Agbl4 gene. PhysGen, Transposagen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Agbl4Tn(sb-T2/Bart3)2.337Mcwi 2313461 5 134582789 135484937 1 - by flanking markers 5 130742297 131656581 1 - by flanking markers 5 125254963 126534367 1 - by flanking markers RRID:RRRC_00473 2313588 SD-Tg(Ins2-IAPP)Soel Crl:SD rats were microinjected with cDNA encompassing the human IAPP was fused with rat insulin II promoter Pfizer, Inc, Groton, Connecticut transgenic Unknown RRID:RGD_2313588 2313693 SHR-Tg(PEPCK-SREBF1)2Ipcv SHR/OlaIpcv zygotes were microinjected with a construct containing rat PEPCK promoter fused to truncated human cDNA encoding SREBF1 (SREBP-1a isoform) and human growth hormone poly-A signal Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic transgenic Unknown SREBF1 69473 RRID:RGD_2313693 2313734 SD-Tg(H1/tetO-RNAi:Insr)29Bdr Fertilized eggs of NTac:SD were microinjected with a construct containing shRNA cassette containing the insulin receptor under the control of H1 promoter with a tetO site and a cassette driving tetR from CAGGS promoter Max-Delbruck Center for Molecular Medicine, Berlin, Germany transgenic Unknown RRID:RGD_2313734 2313735 SD-Tg(H1/tetO-RNAi:Insr)14Bdr Fertilized eggs of NTac:SD were microinjected with a construct containing shRNA cassette containing the insulin receptor under the control of H1 promoter with a tetO site and a cassette driving tetR from CAGGS promoter Max-Delbruck Center for Molecular Medicine, Berlin, Germany transgenic Unknown RRID:RGD_2313735 2313922 F344-Tg(Cyp1a1-Ren2)10.LEW-(D10Rat142-D10Rat15)/Jmul F344-Tg(Cyp1a1-Ren2)10Jmul (also named Ren2.F) males (carrying the transgene Ren2 on chr Y) and Lewis females were bred to produce F1 rats.F1 males were backcrossed to F344 females to produce BC-F344. After 12 backcross nerations, males and females heterozygous for F344/Lew in the reduced MOD QTLregion were brother-sister mated to generate aimals that were homozygous Lew/Lew for the MOD QTL region but homozygous F344/F344 for the rest of the genome. Molecular Physiology Lab, CVS, QMRI, University of Edinburgh, Edinburgh, UK congenic Unknown 10 92448353 96667338 1 - by flanking markers 10 91113514 95243104 1 - by flanking markers 10 91345679 95508221 1 - by flanking markers 10 88207600 92238497 1 - by flanking markers RRID:RGD_2313922 2313923 LEW-Chr YF344-Tg(Cyp1a1-Ren2)10.F344-(D10Rat99-D10Rat11)/Jmul F344-Tg(Cyp1a1-Ren2)10Jmul (also named Ren2.F) males (carrying the transgene Ren2 on chr Y) and Lewis females were bred to produce F1 rats.F1 males were backcrossed to Lew females to produce BC-Lew. After 12 backcross generations, males and females heterozygous for F344/Lew in the MOD QTLregion were brother-sister mated to generate aimals that were homozygous F344/F344 for the MOD QTL region but homozygous LEW/LEW for the rest of the genome. Molecular Physiology Lab, CVS, QMRI, University of Edinburgh, Edinburgh, UK congenic Unknown 10 89278229 100633982 1 - by flanking markers 10 88043769 99184250 1 - by flanking markers 10 88250522 99492409 1 - by flanking markers 10 85269536 96121100 1 - by flanking markers RRID:RGD_2313923 2313924 LEW-Chr YF344-Tg(Cyp1a1-Ren2)10/Jmul F344-Tg(Cyp1a1-Ren2)10Jmul males (carrying the transgene Ren2 on chr Y) were backcrossed with LEW females to generate this consomic strain, confirmed by microsatellite markers Molecular Physiology Lab, CVS, QMRI, University of Edinburgh, Edinburgh, UK consomic Unknown RRID:RGD_2313924 2314001 N:HS Heterogeneous stock Originated from a colony established in 1980 at NIH, animals were bred for 50 generations in a rotational outbreeding regime comprising of 8 inbred progenitors: BN/SsN, MR/N, BUF/N, M520/N, WN/N, ACI/N, WKY/N and F344/N; then to Dr. Eva Redei, Northwestern University (Chicago); 40 breeding pairs were sent from Northwestern University (Chicago) to Barcelona and 25 pairs to Dr. Solberg Woods, Medical College of Wisconsin Dept. of Psychiatry & Forensic Medicine, School of Medicine, Autonomous University of Barcelona, Barcelona, Spain outbred Unknown RRID:RGD_2314001 2314009 NMcwi:HS Heterogeneous stock 25 breeding pairs were obtained from Dr. Eva Redei, Northwestern University (Chicago) at 55 breeding generations; these animals exhibit 30% genome-wide heterozygosity which is maintained by using a rotational breeding strategy were two parameters are used: The first is the number of cages used for breeding and the second is the spacing between each cage (containing a female for mating) and the cage to which it is mated (containing a male for mating). This spacing is called the rotational delay. A rotational delay of 1 is used, in which a female from cage 1 mates with a male from cage 2, a male from cage 2 mates with a female from cage 3, etc. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin outbred Unknown RRID:RGD_2314009 2314027 SDT.Cg-Leprfa/Jtt SDT fatty Leprfa allele from ZDF was introgressed into SDT rats using the speed congenic method Japan Tobacco Inc., Central Pharmaceutical Research Institute, Kanagawa, Japan congenic Unknown RRID:RGD_2314027 2314161 F344-Kuru1/Kyo Kuru1 A mutant rat showing circling phenotype was found in the G1 rats produced by ENU mutagenesis (phenotype-driven). National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm RRID:RGD_2314161 2314162 F344-Oune/Kyo Oune A mutant rat showing abnormal tail was found in the G1 rats produced by ENU mutagenesis (phenotype-driven). National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm Tbx6 1307716 RRID:RGD_2314162 2314163 F344-Kcna1Adms/Kyo ADMS (autosomal dominant myokymia and seizures) rat This strain was established by phenotype-driven ENU mutagenesis. A Kcna1 S309T mutation was identified in this model. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm (as of 2017-05-04) Kcna1Adms 12880383 4 163011777 163013522 1 - by flanking markers 4 226188851 226190596 1 - by flanking markers 4 159190781 159192526 1 - by flanking markers 4 159464223 159472905 1 - by flanking markers RRID:RGD_2314163 2314164 F344-Kuru2/Kyo Kuru2 A mutant rat showing circling phenotype was found in the G1 rats produced by ENU mutagenesis (phenotype-driven). National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm RRID:RGD_2314164 2314165 ACI-Chib/Kyo Chibi This strain was established by phenotype-driven ENU mutagenesis. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Dermatology RRID:RGD_2314165 2314166 F344-Tbr2/Kyo Tsubura2 A mutant rat showing abnormal eyes was found in the G1 rats produced by ENU mutagenesis (phenotype-driven). National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm RRID:RGD_2314166 2314167 F344-Kmch/Kyo Komachi This strain was established by phenotype-driven ENU mutagenesis. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm RRID:RGD_2314167 2314168 F344-Tbr1/Kyo Tsubura1 A mutant rat showing abnormal eyes was found in the G1 rats produced by ENU mutagenesis (phenotype-driven). National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm RRID:RGD_2314168 2314169 WTC.F344-Scn1am1Kyo/Kyo This congenic strain was established by backcrossing F344-Scn1am1Kyo onto WTC/Kyo. National BioResource Project for the Rat in Japan congenic Live Animals; Cryopreserved Sperm RRID:RGD_2314169 2314170 F344-Egrm1Kyo EGR (Excessive Grooming Rat), Kaikai, Kyo1897 This strain was established by phenotype-driven ENU mutagenesis. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm RRID:RGD_2314170 2314224 F344.OLETF-(D1Rat166-D1Rat90)/2Tj Congenic strain originated from backcrossing parental F344/Crlj and OLETF/Otk animals. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 1 255026793 267111153 1 - by flanking markers 1 276721459 289137268 1 - by flanking markers 1 269279863 281795785 1 - by flanking markers 1 248393012 259647894 1 - by flanking markers RRID:RGD_2314224 2314225 F344-Chr 15OLETF/Tj Developed by the depositor National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity RRID:RGD_2314225 2314226 WI-Tg(WSCD2)3Tkyo A transgenic construct consisting of the human WSC domain containing 2 (WSCD2, also known as KIAA0789) within pEF6/Myc-HisA (downstream of the EF-1a promoter and upstream of the bovine growth hormone polyA signal) was injected into Wistar rat (Crlj:WI) embryos. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm WSCD2 1605710 RRID:RGD_2314226 2314227 WI-Tg(WSCD2)4Tkyo A transgenic construct consisting of the human WSC domain containing 2 (WSCD2, also known as KIAA0789) within pEF6/Myc-HisA (downstream of the EF-1a promoter and upstream of the bovine growth hormone polyA signal) was injected into Wistar rat (Crlj:WI) embryos. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm WSCD2 1605710 RRID:RGD_2314227 2314228 WI-Tg(WSCD2)5Tkyo A transgenic construct consisting of the human WSC domain containing 2 (WSCD2, also known as KIAA0789) within pEF6/Myc-HisA (downstream of the EF-1a promoter and upstream of the bovine growth hormone polyA signal) was injected into Wistar rat (Crlj:WI) embryos. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm WSCD2 1605710 RRID:RGD_2314228 2314229 F344.OLETF-(D7Uwm22-D7Mgh20)/Tj Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 7 123733466 123733601 1 - by flanking markers 7 126334525 126334660 1 - by flanking markers 7 126622888 126623023 1 - by flanking markers 7 116836447 116836583 1 - by flanking markers RRID:RGD_2314229 2314230 F344-Hrkrh/Kyo Hairless Kyoto, Hanako A mutant rat showing abnormal skin phenotype was found in the G1 rats produced by ENU mutagenesis (phenotype-driven). National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Dermatology; Urology RRID:RGD_2314230 2314231 F344.OLETF-(D5Mgh5-D5Mgh23)/2Tj Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.37.4 cM segment of the OLETF genome was transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 5 45499364 115361927 1 - by flanking markers 5 49028773 117961491 1 - by flanking markers 5 44404276 114014945 1 - by flanking markers 5 43726656 109897936 1 - by flanking markers RRID:RGD_2314231 2314232 WI-Tg(WSCD2)1Tkyo A transgenic construct consisting of the human WSC domain containing 2 (WSCD2, also known as KIAA0789) within pEF6/Myc-HisA (downstream of the EF-1a promoter and upstream of the bovine growth hormone polyA signal) was injected into Wistar rat (Crlj:WI) embryos. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm WSCD2 1605710 RRID:RGD_2314232 2314243 SHR.WKY-(D1Mgh2-D1Wox10)/IzmTkyo Developed by the depositor National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cardio Hypertension 1 22842898 220639653 1 - by flanking markers 1 24875821 244066407 1 - by flanking markers 1 23406428 236763528 1 - by flanking markers 1 22340647 214537671 1 - by flanking markers RRID:RGD_2314243 2314244 BCR/Nn In the course of producing transgenic rats (DRPLA promoter + huntingtin exon1+EGFP on a Slc:SD background), a mutant rat showing involuntary movements (circling) and symptoms of dystonia was found in F6 progeny. Subsequent by the selection of the involuntary movement segregated the transgene from the phenotype. Thereafter this strain was maintained by only the phenotype (not the transgene). National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Neurobiology RRID:RGD_2314244 2314245 WI-Tg(WSCD2)6Tkyo A transgenic construct consisting of the human WSC domain containing 2 (WSCD2, also known as KIAA0789) within pEF6/Myc-HisA (downstream of the EF-1a promoter and upstream of the bovine growth hormone polyA signal) was injected into Wistar rat (Crlj:WI) embryos. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm WSCD2 1605710 RRID:RGD_2314245 2314246 SHRSP.WKY-(D1Rat117-D1Rat90)/IzmTkyo Developed by the Depositor National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Cardio Hypertension 1 219629755 267111153 1 - by flanking markers 1 240604381 289137268 1 - by flanking markers 1 233490105 281795785 1 - by flanking markers 1 213533809 259647894 1 - by flanking markers RRID:RGD_2314246 2314247 WI-Tg(Prl-EGFP)Yamp A transgenic construct was designed with the rat prolactin promoter (-3221 - 3233) controlling EGFP. Transgenic rats originated from Crlj:WI (Wistar) rats National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Metabolism; Development RRID:RGD_2314247 2314313 NER.F344-(D5Rat100-D5Rat234)/Kyo The Ner3 region (D5Rat100-D5Rat234) was introgressed from F344/NSlc onto NER/Kyo by backcross breeding. National BioResource Project for the Rat in Japan congenic Unknown Neurobiology 5 68843563 68843964 1 - by flanking markers 5 70180341 70180484 1 - by flanking markers 5 65696672 65696815 1 - by flanking markers 5 66174080 66174226 1 - by flanking markers RRID:RGD_2314313 2314314 NER.F344-(D1Mgh6-D1Rat132)/Kyo The Ner1 region (D1Mgh6-D1Rat132) was introgressed from F344/NSlc onto NER/Kyo by backcross breeding. National BioResource Project for the Rat in Japan congenic Unknown Neurobiology 1 87656636 165996388 1 - by flanking markers 1 92524380 179788206 1 - by flanking markers 1 91394009 172789257 1 - by flanking markers 1 87790149 162457491 1 - by flanking markers RRID:RGD_2314314 2314315 F344.NER-(D5Mgh4-D5Rat36)/Kyo The Ner3 region (D5Mgh4-D5Rat36) was introgressed from NER/Kyo onto F344/NSlc by backcross breeding. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 5 145186817 145187034 1 - by flanking markers 5 147610023 147610238 1 - by flanking markers 5 143846157 143846372 1 - by flanking markers 5 138113556 138113774 1 - by flanking markers RRID:RGD_2314315 2314316 F344.NER-(D1Mgh6-D1Rat73)/Kyo The Ner1 region (D1Mgh6-D1Rat73) was introgressed from NER/Kyo onto F344/NSlc by backcross breeding. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 1 87656636 224420760 1 - by flanking markers 1 92524380 246113473 1 - by flanking markers 1 91394009 238824901 1 - by flanking markers 1 87790149 218748178 1 - by flanking markers RRID:RGD_2314316 2314317 WTC.GRY-Cacna1agry/Kyo Developed by the depositor National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2017-05-04) Neurobiology Cacna1a|Cacna1agry 2244|12880382 RRID:RGD_2314317 2314339 F344-PatjTn(sb-T2/Bart3)2.343Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 15th intron of the Inadl gene. PhysGen, Rat Resource & Research Center mutant Cryopreserved Sperm (as of 2017-01-26) PatjTn(sb-T2/Bart3)2.343Mcwi 2314335 5 118806744 119131114 1 - by flanking markers 5 120981525 121281044 1 - by flanking markers 5 117038548 117340308 1 - by flanking markers 5 113061985 113364807 1 - by flanking markers RRID:RRRC_00480 2314340 F344-AcoxlTn(sb-T2/Bart3)2.342Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 10th intron of the Acoxl gene. PhysGen mutant Extinct (as of 2016-10-24) AcoxlTn(sb-T2/Bart3)2.342Mcwi 2314337 3 115365279 115687566 1 - by flanking markers 3 126606586 126919666 1 - by flanking markers 3 120414311 120724809 1 - by flanking markers 3 115061045 115367032 1 - by flanking markers RRID:RGD_2314340 2314341 F344-Auts2Tn(sb-T2/Bart3)2.344Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 14th intron of the Auts2 gene. PhysGen mutant Extinct (as of 2016-10-24) Auts2Tn(sb-T2/Bart3)2.344Mcwi 2314338 12 25518248 25541023 1 - by flanking markers 12 24104187 25194123 1 - by flanking markers RRID:RGD_2314341 2314342 F344-PalldTn(sb-T2/Bart3)2.341Mcwi These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 19th intron of the Palld gene. PhysGen mutant Extinct (as of 2017-01-26) PalldTn(sb-T2/Bart3)2.341Mcwi 2314336 16 31144028 31144544 1 - by flanking markers 16 31198863 31240064 1 - by flanking markers 16 31349140 31390340 1 - by flanking markers 16 27981315 28143129 1 - by flanking markers RRID:RGD_2314342 2314360 ACI.F344-(D16Mit5-D16Nkg27)/Nkg This congenic strain was established by backcrossing ACI.F344-(D16Rat12-D16Mco2)Nkg onto ACI/NJcl, followed by intercrossing in N6 generation, thereafter maintained by crossing homozygous individuals. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cancer RRID:RGD_2314360 2314361 W-Tg(Slc32a1-YFP*)1Yyan This transgenic rat was established at National Institute for Physiological Sciences in 2004, thereafter introduced to Gunma University in 2006. National BioResource Project for the Rat in Japan transgenic Live Animals; Cryopreserved Sperm Neurobiology; Development RRID:RGD_2314361 2314362 F344-Hrdk/Kyo Hairless dominant Kyoto Hairless mutation was found in the G1 rats that established by ENU mutagenesis (phenotype driven). National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm RRID:RGD_2314362 2314363 W-Tg(Slc32a1-YFP*)2Yyan This transgenic rat was established at National Institute for Physiological Sciences in 2004, thereafter introduced to Gunma University in 2006. National BioResource Project for the Rat in Japan transgenic Live Animals; Cryopreserved Sperm Neurobiology; Development RRID:RGD_2314363 2314364 ACI.F344-(D16Nkg112-D16Nkg27)/Nkg This congenic strain was established by backcrossing ACI.F344-(D16Nkg9-D16Nkg27)Nkg onto ACI/NJcl, followed by intercrossing in N3 generation, thereafter maintained by crossing homozygous individuals. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cancer RRID:RGD_2314364 2314365 KFRS2/Kyo A male rat "SRR-Do Your Best" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "SRR-Do Your Best" and a female PVG/Seac. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Ophthalmology; Dermatology Tyr|TyrsiaKyo 1589755|13207345 1 143641257 143746315 1 - by flanking markers 1 157322968 157416594 1 - by flanking markers 1 151012598 151106802 1 - by flanking markers 1 141115036 141210207 1 - by flanking markers RRID:RGD_2314365 2314368 F344-Trdk/Kyo Tremor dominant Kyoto Tremor dominant Kyoto (Trdk) mutation is an autosomal dominant mutation that appeared in 2008 in a stock of F344/NSlc rats that had been mutagenized with N-ethyl-N-nitrosourea (ENU) (Mashimo et al., 2008). Rats heterozygous for Trdk (Trdk/+) exhibited tremor behavior that was evident around weaning. To remove latent ENU-induced mutations, the laboratory established an F344-Trdk/+ congenic strain by nine rounds of backcrossing. Using positional candidate approach, Trdk mutation was identified as a missense substitution (c. 866 T > A, p. I289N) in Kcnn2,. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2021-07-15) Neurobiology Kcnn2Trdk 149735330 18 39560962 39705037 1 - by flanking markers 18 38822146 38864110 1 - by flanking markers 18 39331894 39479574 1 - by flanking markers 18 37817966 38258347 1 - by flanking markers RRID:RGD_2314368 2314375 LE.AR-Ednrbsl/Okkm AR rats were found a by Ikadai et al. at Institute for Animal Reproduction in 1973. From 1997, backcross of AR rats onto Long Evans rats has started. After the 9th generation of backcrossing, it has been maintained by sib mating (F10 in May 2008). National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2017-03-28) Internal Organ Ednrb|Ednrbsl 2536|10755424 15 87893141 87898700 1 - by flanking markers 15 91500400 91531979 1 - by flanking markers 15 88004775 88036354 1 - by flanking markers 15 80640839 80672115 1 - by flanking markers RRID:RGD_2314375 2314376 KFRS4/Kyo A male rat "TSR Louis" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "TSR Louis" and a female PVG/Seac. This strain carries two mutations, head spot (hs) which causes white spotting on the head, and dumbo (dmbo) which causes abnormal ear morphology (Kuramoto, 2010, RGD:7800655). Ears are set lower on the head, and are larger and rounder. Genetic analyses mapped hs to Chr 15 and dmbo to Chr 14. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Embryo (as of 2021-10-05) Ophthalmology; Dermatology RRID:RGD_2314376 2314377 KFRS3B/Kyo A male rat "SRR-Rocket Science" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "SRR-Rocket Science" and a female PVG/Seac. Homozygous rats for grey mutation were selected for inbreeding. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Ophthalmology; Dermatology RRID:RGD_2314377 2314378 AR-Ednrbsl/Okkm Aganglionosis rat Congenital megacolon rats were found in offspring of a female albino rat crossed with a wild male by Ikadai et al. at Institute for Animal Reproduction in 1973 and were named Aganglionosis Rat (AR) National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2016-10-31) Internal Organ Ednrb|Ednrbsl 2536|10755424 15 87893141 87898700 1 - by flanking markers 15 91500400 91531979 1 - by flanking markers 15 88004775 88036354 1 - by flanking markers 15 80640839 80672115 1 - by flanking markers RRID:RGD_2314378 2314379 KFRS6/Kyo A male rat "SRR Tustin" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "SRR Tustin" and a female TM/Kyo. National BioResource Project for the Rat in Japan mutant Live Animals Dermatology RRID:RGD_2314379 2314380 SD-Tg(CAG-lacZ)541Htsu Developed by the depositor National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_2314380 2314381 KFRS5A/Kyo A male rat "SRR Coming Home" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "SRR Coming Home" and a female TM/Kyo. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Dermatology Krt71Rex 11570416 7 141143396 141166531 1 - by flanking markers 7 143345201 143371346 1 - by flanking markers 7 132873532 132898975 1 - by flanking markers RRID:RGD_2314381 2314382 SD-Tg(CAG-HRAS*G12V)250Htsu This transgenic strain was established by CLEA Japan, Inc. The construct is as follows: CAG promoter, loxP sequence, neomycin resistance gene, loxP sequence and Ha-ras*G12V (HrasV12). It was injected into Jcl:SD embryos, the transgene is regulated by the Cre/loxP system. Human Ha-ras*G12V oncogene is driven by CAG promoter National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Cancer HRAS 730881 RRID:RGD_2314382 2314383 KFRS3A/Kyo A male rat "SRR-Rocket Science" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "SRR-Rocket Science" and a female PVG/Seac. Homozygous rats for mink were selected for inbreeding. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Ophthalmology; Dermatology RRID:RGD_2314383 2314396 LCR/Mco Low-capacity runners Artificially selected for intrinsic aerobic running capacity from the heterogenous stock (N:HS); these were selected for low capacity based on distance run to exhaustion on a motorized treadmill. Medical College of Ohio, Toledo, Ohio, USA inbred Unknown RRID:RGD_2314396 2314397 HCR/Mco High-capacity runners Artificially selected for intrinsic aerobic running capacity from the heterogenous stock (N:HS); these were selected for high capacity based on distance run to exhaustion on a motorized treadmill. Medical College of Ohio, Toledo, Ohio, USA inbred Unknown RRID:RGD_2314397 2314414 LEW-Tg(H1/tetO-RNAi:Insr)87Hrjb LEW/Crl rat embryos were microinjected with an lentiviral single vector system comprising of Insr-specific shRNA construct under the control of H1t promoter Department of Cellular and Molecular Immunology, University of Gottingen, Gottingen, Germany transgenic Unknown Insr 2917 RRID:RGD_2314414 2314415 LEW-Tg(H1/tetO-RNAi:Insr)4Hrjb LEW/Crl rat embryos were microinjected with an lentiviral single vector system comprising of Insr-specific shRNA construct under the control of H1t promoter Department of Cellular and Molecular Immunology, University of Gottingen, Gottingen, Germany transgenic Unknown Insr 2917 RRID:RGD_2314415 2314477 LEW-RT1DA/Rrrc Sprague-Dawley RT1u haplotype backcrossed onto Lewis inbred strain. Rat Resource and Research Center congenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00391 2314478 LEW-RT1.Bm1Trg/Rrrc RT1.B ENU induced mutation in a Sprague Dawley rat resulting in a phenotypic change at the RT1.B MHC locus such that antibody binding to the RT1.B locus is no longer present. Animals carrying this mutation fail to have OX-6 antibody binding to the RT1.B locus. The exact nature of the mutation has not been genetically characterized. Mutation was backcrossed onto the Lewis strain. Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00392 2314492 SBN.SBH-(D1Rat148-D1Rat89)/Ygl Segment of interest from chr 1 of SBH/Ygl was introgressed onto the genetic background of SBN/Ygl this was done by crossing male SBN/Ygl with female SBH/Ygl fixing the Y chr to SBN/Ygl Ben Gurion University Barzilai Medical Center, Ashkelon, Israel congenic Unknown 1 16325337 265343617 1 - by flanking markers 1 18951160 287349830 1 - by flanking markers 1 16470664 279986079 1 - by flanking markers 1 15760582 257976495 1 - by flanking markers RRID:RGD_2314492 2314493 SBH.SBN-(D1Mgh2-D1Rat74)/Ygl Segment of interest from chr 1 of SBN/Ygl was introgressed onto the genetic background of SBH/Ygl this was done by crossing male SBH/Ygl with female SBN/Ygl fixing the Y chr to SBN/Ygl Ben Gurion University Barzilai Medical Center, Ashkelon, Israel congenic Unknown 1 22842898 227005733 1 - by flanking markers 1 24875821 248763894 1 - by flanking markers 1 23406428 241482368 1 - by flanking markers 1 22340647 221264292 1 - by flanking markers RRID:RGD_2314493 2314494 SBH.SBN-(D1Rat137-D1Rat123)/Ygl Segment of interest from chr 1 of SBN/Ygl was introgressed onto the genetic background of SBH/Ygl this was done by crossing male SBH/Ygl with female SBN/Ygl fixing the Y chr to SBN/Ygl Ben Gurion University Barzilai Medical Center, Ashkelon, Israel congenic Unknown 1 90306033 223729371 1 - by flanking markers 1 95325941 245519018 1 - by flanking markers 1 94225372 238220385 1 - by flanking markers 1 90532338 218108781 1 - by flanking markers RRID:RGD_2314494 2314495 SBN.SBH-(D1Rat27-D1Mit7)/Ygl Segment of interest from chr 1 of SBH/Ygl was introgressed onto the genetic background of SBN/Ygl this was done by crossing female SBN/Ygl with male SBH/Ygl fixing the Y chr to SBH/Ygl Ben Gurion University Barzilai Medical Center, Ashkelon, Israel congenic Unknown 1 90282040 240980321 1 - by flanking markers 1 95301716 262617374 1 - by flanking markers 1 94201400 94201552 1 - by flanking markers 1 90508614 90508767 1 - by flanking markers RRID:RGD_2314495 2314496 SBH.SBN-(D1Mgh2-D1Mgh11)/Ygl Segment of interest from chr 1 of SBN/Ygl was introgressed onto the genetic background of SBH/Ygl this was done by crossing female SBH/Ygl with male SBN/Ygl fixing the Y chr to SBN/Ygl Ben Gurion University Barzilai Medical Center, Ashkelon, Israel congenic Unknown 1 22842898 22843363 1 - by flanking markers 1 24875821 24875970 1 - by flanking markers 1 23406428 23406577 1 - by flanking markers 1 22340647 22340797 1 - by flanking markers RRID:RGD_2314496 2314497 SBN.SBH-(D1Rat101-D1Rat74)/Ygl Segment of interest from chr 1 of SBH/Ygl was introgressed onto the genetic background of SBN/Ygl this was done by crossing male SBN/Ygl with female SBH/Ygl fixing the Y chr to SBN/Ygl Ben Gurion University Barzilai Medical Center, Ashkelon, Israel congenic Unknown 1 97174943 227005733 1 - by flanking markers 1 103735751 248763894 1 - by flanking markers 1 102658741 241482368 1 - by flanking markers 1 97146283 221264292 1 - by flanking markers RRID:RGD_2314497 2314498 SBH.SBN-(D1Rat137-D1Rat83)/Ygl Segment of interest from chr 1 of SBN/Ygl was introgressed onto the genetic background of SBH/Ygl this was done by crossing female SBH/Ygl with male SBN/Ygl fixing the Y chr to SBN/Ygl Ben Gurion University Barzilai Medical Center, Ashkelon, Israel congenic Unknown 1 90306033 252133935 1 - by flanking markers 1 95325941 274017147 1 - by flanking markers 1 94225372 266587220 1 - by flanking markers 1 90532338 245701099 1 - by flanking markers RRID:RGD_2314498 2314499 SBN.SBH-(D1Mgh17-D1Mgh14)/Ygl Segment of interest from chr 1 of SBH/Ygl was introgressed onto the genetic background of SBN/Ygl this was done by crossing female SBN/Ygl with male SBH/Ygl fixing the Y chr to SBH/Ygl Ben Gurion University Barzilai Medical Center, Ashkelon, Israel congenic Unknown 1 9082836 263699089 1 - by flanking markers 1 10007292 285604895 1 - by flanking markers 1 8387052 278228889 1 - by flanking markers 1 8606496 256448636 1 - by flanking markers RRID:RGD_2314499 2314500 SBH.SBN-(D1Mgh2-D1Rat101)/Ygl Segment of interest from chr 1 of SBN/Ygl was introgressed onto the genetic background of SBH/Ygl this was done by crossing female SBH/Ygl with male SBN/Ygl fixing the Y chr to SBN/Ygl Ben Gurion University Barzilai Medical Center, Ashkelon, Israel congenic Unknown 1 22842898 97175101 1 - by flanking markers 1 24875821 103735908 1 - by flanking markers 1 23406428 102658898 1 - by flanking markers 1 22340647 97146439 1 - by flanking markers RRID:RGD_2314500 2314501 SBH.SBN-(D1Wox11-D1Rat137)/Ygl Segment of interest from chr 1 of SBN/Ygl was introgressed onto the genetic background of SBH/Ygl this was done by crossing male SBH/Ygl with female SBN/Ygl fixing the Y chr to SBN/Ygl Ben Gurion University Barzilai Medical Center, Ashkelon, Israel congenic Unknown 1 64145811 90306478 1 - by flanking markers 1 63399232 95326185 1 - by flanking markers 1 64407177 94225616 1 - by flanking markers 1 65832929 90532583 1 - by flanking markers RRID:RGD_2314501 2314530 SS.SHR-(D8Uia1-D8Rat90)/Mco SS/Jr females were bred with SHR/NHsd males and their female F1 were backcrossed to SHR/NHsd males; this ensured that the mitochondrial genome came from SS/Jr; further selection was done using microsatellite markers Medical College of Ohio, Toledo, Ohio congenic Unknown 8 19055857 114974688 1 - by flanking markers 8 20954930 118204000 1 - by flanking markers 8 118862625 118862813 1 - by flanking markers 8 110572032 110572221 1 - by flanking markers RRID:RGD_2314530 2314531 SHR.SS-(D13Rat1-D13Mgh6)/Mco SS/Jr females were bred with SHR/NHsd males and their male F1 were backcrossed to SHR/NHsd females; this ensured that the mitochondrial genome came from SHR/NHsd; further selection was done using microsatellite markers Medical College of Ohio, Toledo, Ohio congenic Unknown 13 10555730 101704301 1 - by flanking markers 13 29679984 108279142 1 - by flanking markers 13 24501968 103613733 1 - by flanking markers 13 20605555 97213863 1 - by flanking markers RRID:RGD_2314531 2314532 SHR.SS-(D8Uia1-D8Rat90)/Mco SS/Jr females were bred with SHR/NHsd males and their male F1 were backcrossed to SHR/NHsd females; this ensured that the mitochondrial genome came from SHR/NHsd; further selection was done using microsatellite markers Medical College of Ohio, Toledo, Ohio congenic Unknown 8 19055857 114974688 1 - by flanking markers 8 20954930 118204000 1 - by flanking markers 8 118862625 118862813 1 - by flanking markers 8 110572032 110572221 1 - by flanking markers RRID:RGD_2314532 2314655 BRAT-Avpdi/BluHsd Brattleboro Hereditary hypothalamic diabetes insipidus was first described in offspring from a Long-Evans stock of rats by Dr. Schroeder, later named Brattleboro strain. In 1964 from Dr. Lewis Kinder, Harvard University, Boston to Blue Spruce Farms, Altamont, New York. to Harlan through acquisition in 1988. mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-06-21) Avpdi 13627261 3 118205007 118206985 1 - by flanking markers 3 129615610 129627147 1 - by flanking markers 3 123117482 123119460 1 - by flanking markers 3 117793447 117805091 1 - by flanking markers RRID:RGD_2314655 2314861 WAG/RijYcb Substrain of WAG/Rij; from Netherlands to Yale University. Comparative Medicine, Yale University, Connecticut inbred Unknown RRID:RGD_2314861 2314904 WAG-F8m1Ycb This mutant strain carrying a naturally occurring missense mutation displays inherited coagulopathy was arising in an inbred colony of WAG/RijYcb (RGD:2314861). Mutation in the nucleotide 578 of the rat F8 gene changes amino acid 193 in the rat protein(amino acid 176 in human)from Leucine to Proline. Comparative Medicine, Yale University, Connecticut mutant Unknown F8m1Ycb 2314903 18 121134 162008 1 - by flanking markers 18 413447 444491 1 - by flanking markers 18 367862 399242 1 - by flanking markers 18 140848 172330 1 - by flanking markers RRID:RGD_2314904 2314928 Slc:W Slc: Wistar Institute of Medical Science, University of Tokyo(1974). Hysterectomy and fostering are used for obtaining SPF animals of this strain. SLC, Japan outbred Unknown RRID:RGD_2314928 2314934 WST.F344-Ker/Kyo Wistar/ST-Boo This congenic strain was established by backcrossing F344-Ker/Kyo (NBRP No.0458) onto Slc:WST National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm RRID:RGD_2314934 2314935 WST.F344-Kmch/Kyo Wistar/ST-Komachi This congenic strain was established by backcrossing F344-Kmch/Kyo (NBRP No.0458) onto Slc:WST. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm RRID:RGD_2314935 2314936 WI-Tg(WSCD2)Tkyo A transgenic construct consisting of the human WSC domain containing 2 (WSCD2, also known as KIAA0789) within pEF6/Myc-HisA (downstream of the EF-1a promoter and upstream of the bovine growth hormone polyA signal) was injected into Wistar rat (Crlj:WI) embryos. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2017-08-24) RRID:RGD_2314936 2314937 F344.OLETF-(D5Mgh20-D5Mgh22)/Tj Developed by the depositor National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity 5 140925168 157584492 1 - by flanking markers 5 143051962 160953783 1 - by flanking markers 5 139267814 157212422 1 - by flanking markers 5 133916727 151006154 1 - by flanking markers RRID:RGD_2314937 2316631 F344.GK-(D1Swe8-D1Gpam-1)/Swe This sub-congenic strain is generated from an F2- intercross between F344/DuCrlSwe and F344.GK-(D1Arb42a-D1Rat90)/Swe Karolinska Institutet, Stockholm, Sweden congenic Unknown Adra2a|Pdcd4|Shoc2 2056|620816|1308146 1 259866528 259866737 1 - by flanking markers 1 281763458 281763667 1 - by flanking markers 1 274353782 274353991 1 - by flanking markers 1 252645447 252645657 1 - by flanking markers RRID:RGD_2316631 2316632 NEDH/KSim New England Deaconess Hospital Inbred from Wistar rats by S. Warren then to Simonsen Laboratories in 1987 by B. Hoffman Simonsen Laboratories inbred Unknown RRID:RGD_2316632 2316633 F344.GK-(D1Got251-D1Gpam-1)/Swe This sub-congenic strain is generated from an F2- intercross between F344/DuCrlSwe and F344.GK-(D1Arb42a-D1Rat90)/Swe Karolinska Institutet, Stockholm, Sweden congenic Unknown 1 260641680 260641846 1 - by flanking markers 1 282550224 282550389 1 - by flanking markers 1 275138749 275138914 1 - by flanking markers 1 253439653 253439819 1 - by flanking markers RRID:RGD_2316633 2316653 SS.LEW-(D1Mco102-D1Got46)/Mco A sub-congenic strain derived from SS.LEW-(D1Uia8-D1Rat18)/Mco contributing to the introgressed LEW allele Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown 1;17 38394289;2374083 38394434;2374266 1 - by flanking markers;1 - by flanking markers 1 36290530 45656739 1 - by flanking markers 1 34888392 44326906 1 - by flanking markers 1 32249735 44011366 1 - by flanking markers RRID:RGD_2316653 2316654 SS.LEW-(D1Mco102-D1Mco129)/1Mco A sub-congenic strain derived from SS.LEW-(D1Mco102-D1Got46)/Mco contributing to the introgressed LEW allele crossed to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown 17 2374083 3178843 1 - by flanking markers 1 36290530 37078065 1 - by flanking markers 1 34888392 35680732 1 - by flanking markers 1 32249735 33038814 1 - by flanking markers RRID:RGD_2316654 2316655 SS.LEW-(D1Mco102-D1Mco129)/2Mco A sub-congenic strain derived from SS.LEW-(D1Mco102-D1Got46)/Mco contributing to the introgressed LEW allele crossed to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown 17 2374083 3178843 1 - by flanking markers 1 36290530 37078065 1 - by flanking markers 1 34888392 35680732 1 - by flanking markers 1 32249735 33038814 1 - by flanking markers RRID:RGD_2316655 2316925 SHR.BN-(D3Rat159-D3Rat1)/Mco 50.6 Mb region of BN/SsNHsd is introgressed into the genomic background of SHR/NHsd Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 3 119437175 170016653 1 - by flanking markers 3 130776038 180128021 1 - by flanking markers 3 124284647 176418101 1 - by flanking markers 3 118950053 168026850 1 - by flanking markers RRID:RGD_2316925 2316927 SHR.BN-(D6Rat40-D6Rat170)/Mco 45.5 Mb region of BN/SsNHsd is introgressed into the genomic background of SHR/NHsd Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 6 1301952 46792623 1 - by flanking markers 6 1111498 56881356 1 - by flanking markers 6 1120393 48179481 1 - by flanking markers 6 16536243 45547114 1 - by flanking markers RRID:RGD_2316927 2316928 SHR.BN-(D3Rat159-D3Rat1)(D6Rat40-D6Rat170)/Mco this double congenic strain is bred by crossing female SHR.BN-(D6Rat40-D6Rat170)/Mco with male SHR.BN-(D3Rat159-D3Rat1)/Mco and selecting heterozygous animals in the F1 progeny; these were then mated to fix the BN allele Medical College of Ohio, Toledo, Ohio, USA congenic Unknown RRID:RGD_2316928 2317196 DA.PVG.1AV1-(D8Rat146-D8Got145) Males with PVG.1AV1 allele were selected from the G8 advanced intercross line (AIL) and mated with DA females to tranfer a short well-defined (73.1-91.3 Mb) region that has the region of interest Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden congenic Unknown 8 73105403 91329867 1 - by flanking markers 8 76885501 93261060 1 - by flanking markers 8 74920991 93746162 1 - by flanking markers 8 69352596 87043114 1 - by flanking markers RRID:RGD_2317196 2317197 DA.PVG.1AV1-(D8Rat41-D8Rat24) Males with PVG.1AV1 allele were selected from the G8 advanced intercross line (AIL) and mated with DA females to tranfer a short well-defined (50.4-82.2 Mb) region that has the region of interest Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden congenic Unknown 8 50354908 82247243 1 - by flanking markers 8 50240107 84140836 1 - by flanking markers 8 51633707 84569318 1 - by flanking markers 8 47627235 78138314 1 - by flanking markers RRID:RGD_2317197 2317201 DA.PVG.1AV1-(D8Rat24-D8Got145) DA.PVG.1AV1-(D8Rat146-D8Got145) was backcrossed to the recipient DA for 9 generations to create this congenic with less than 0.1% genome outside the desired locus Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden congenic Unknown 8 82246890 91329867 1 - by flanking markers 8 84140683 93261060 1 - by flanking markers 8 84569165 93746162 1 - by flanking markers 8 78138158 87043114 1 - by flanking markers RRID:RGD_2317201 2317278 Taiep/Dun These mutants were found in Sprague-Dawley rats at University of Puebla in 1989 Dept of Medical Sciences, University of Wisconsin-Madison, Madison, Wisconsin mutant Unknown RRID:RGD_2317278 2317590 DA.PVG.1AV1-(D4Rat23-D4Rat108)/Kini Congenic substrain established by intercrossing DA.PVG.1AV1-(D4Rat155-Spr) with parental DA/Kini Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 4 58550170 82090355 1 - by flanking markers 4 58518376 148552304 1 - by flanking markers 4 83889402 83889539 1 - by flanking markers 4 82844048 82844186 1 - by flanking markers RRID:RGD_2317590 2317595 DA.PVG.1AV1-(D4Rat23-D4Mit12)/Kini Congenic substrain established by intercrossing DA.PVG.1AV1-(D4Rat155-Spr) with parental DA/Kini Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 4 58550170 104416171 1 - by flanking markers 4 58518376 163844298 1 - by flanking markers 4 99066972 99067150 1 - by flanking markers 4 103194805 103194984 1 - by flanking markers RRID:RGD_2317595 2317596 DA.PVG.1AV1-(D4Rat103-D4Mit12)/Kini Congenic substrain established by intercrossing DA.PVG.1AV1-(D4Rat155-Spr) with parental DA/Kini Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 4 82700691 104416171 1 - by flanking markers 4 149135946 163844298 1 - by flanking markers 4 84475257 99067150 1 - by flanking markers 4 83428419 103194984 1 - by flanking markers RRID:RGD_2317596 2317598 DA.PVG.1AV1-(D4Rat231-D4Mit12)/Kini Congenic substrain established by intercrossing DA.PVG.1AV1-(D4Rat155-Spr) with parental DA/Kini Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 4 88462327 104416171 1 - by flanking markers 4 154593964 163844298 1 - by flanking markers 4 89777552 99067150 1 - by flanking markers 4 88656681 103194984 1 - by flanking markers RRID:RGD_2317598 2317599 DA.PVG.1AV1-(D4Got211-D4Mit12)/Kini Congenic substrain established by intercrossing DA.PVG.1AV1-(D4Rat155-Spr) with parental DA/Kini Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 4 79604076 104416171 1 - by flanking markers 4 145804154 163844298 1 - by flanking markers 4 81136696 99067150 1 - by flanking markers 4 80445377 103194984 1 - by flanking markers RRID:RGD_2317599 2317791 DA.PVG.1AV1-(D4Got60-D4Kini1)/Kini Congenic substrain established by intercrossing DA.PVG.1AV1-(D4Rat155-Spr) with parental DA/Kini Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 4 80704779 81729771 1 - by flanking markers 4 147125280 148194009 1 - by flanking markers 4 83531021 83531176 1 - by flanking markers 4 82490359 82490515 1 - by flanking markers RRID:RGD_2317791 2317812 AT.ANT-(D1Uia12-D1Rat288)/Rar F2 males with desired fragment of ANT were selected by genotyping and backcrossed to AT rats, this process was repeated for 6 generations and offsprings were tested University of Colorado Denver, Colorado, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-26) 1 134007903 192038535 1 - by flanking markers 1 140949643 211567839 1 - by flanking markers 1 139972085 139972231 1 - by flanking markers 1 132214399 132214546 1 - by flanking markers RRID:RRRC_00728 2317813 AT.ANT-(D1Rat234-D1Rat47)/Rar This sub-congenic was developed by crossing AT.ANT-(D1Rat234-D1Rat228)/Rar with AT University of Colorado Denver, Colorado congenic Unknown 1 41225047 158511230 1 - by flanking markers 1 172296302 172296459 1 - by flanking markers 1 166100317 166100474 1 - by flanking markers 1 155422851 155423009 1 - by flanking markers RRID:RGD_2317813 2317814 AT.ANT-(D1Rat273-D1Rat158)/Rar This sub-congenic was developed by crossing AT.ANT-(D1Rat234-D1Rat228)/Rar with AT University of Colorado Denver, Colorado congenic Unknown 1 140644473 153578547 1 - by flanking markers 1 147436666 167535765 1 - by flanking markers 1 146507930 161321256 1 - by flanking markers 1 138344856 150700247 1 - by flanking markers RRID:RGD_2317814 2317815 AT.ANT-(D1Rat35-D1Rat47)/Rar This sub-congenic was developed by crossing AT.ANT-(D1Rat234-D1Rat228)/Rar with AT University of Colorado Denver, Colorado congenic Unknown 1 124748920 158511230 1 - by flanking markers 1 131958920 172296459 1 - by flanking markers 1 130917121 166100474 1 - by flanking markers 1 123479780 155423009 1 - by flanking markers RRID:RGD_2317815 2317816 AT.ANT-(D1Rat234-D1Rat158)/Rar This sub-congenic was developed by crossing AT.ANT-(D1Rat234-D1Rat228)/Rar with AT University of Colorado Denver, Colorado congenic Unknown 1 41225047 153578547 1 - by flanking markers 1 167535661 167535765 1 - by flanking markers 1 161321152 161321256 1 - by flanking markers 1 150700142 150700247 1 - by flanking markers RRID:RGD_2317816 2317817 AT.ANT-(D1Rat183-D1Rat288)/Rar This sub-congenic was developed by crossing AT.ANT-(D1Rat234-D1Rat288)/Rar with AT University of Colorado Denver, Colorado congenic Unknown 1 131123181 192038535 1 - by flanking markers 1 138077032 211567839 1 - by flanking markers 1 137083889 137084126 1 - by flanking markers 1 129384185 129384427 1 - by flanking markers RRID:RGD_2317817 2317818 AT.ANT-(D1Rat273-D1Rat288)/Rar This sub-congenic was developed by crossing AT.ANT-(D1Rat234-D1Rat288)/Rar with AT University of Colorado Denver, Colorado congenic Unknown 1 140644473 192038535 1 - by flanking markers 1 147436666 211567839 1 - by flanking markers 1 146507930 146508090 1 - by flanking markers 1 138344856 138345017 1 - by flanking markers RRID:RGD_2317818 2317819 AT.ANT-(D1Rat35-D1Rat288)/Rar This sub-congenic was developed by crossing AT.ANT-(D1Rat234-D1Rat288)/Rar with AT University of Colorado Denver, Colorado congenic Unknown 1 124748920 192038535 1 - by flanking markers 1 131958920 211567839 1 - by flanking markers 1 130917121 130917265 1 - by flanking markers 1 123479780 123479925 1 - by flanking markers RRID:RGD_2317819 2317820 AT.ANT-(D1Rat158-D1Rat288)/Rar This sub-congenic was developed by crossing AT.ANT-(D1Rat234-D1Rat288)/Rar with AT University of Colorado Denver, Colorado congenic Unknown 1 153578442 192038535 1 - by flanking markers 1 167535661 211567839 1 - by flanking markers 1 161321152 161321256 1 - by flanking markers 1 150700142 150700247 1 - by flanking markers RRID:RGD_2317820 2317822 AT.ANT-(D1Rat35-D1Rat38)/Rar This sub-congenic was developed by crossing AT.ANT-(D1Rat234-D1Rat228)/Rar with AT University of Colorado Denver, Colorado congenic Unknown 1 124748920 133567105 1 - by flanking markers 1 131958920 140507239 1 - by flanking markers 1 130917121 139524104 1 - by flanking markers 1 123479780 131763614 1 - by flanking markers RRID:RGD_2317822 2317825 AT.ANT-(D1Rat234-D1Rat35)/Rar This sub-congenic was developed by crossing AT.ANT-(D1Rat234-D1Rat228)/Rar with AT University of Colorado Denver, Colorado congenic Unknown 1 41225047 124749065 1 - by flanking markers 1 131958920 131959064 1 - by flanking markers 1 130917121 130917265 1 - by flanking markers 1 123479780 123479925 1 - by flanking markers RRID:RGD_2317825 2317827 AT.ANT-(D1Rat234-D1Rat38)/Rar This sub-congenic was developed by crossing AT.ANT-(D1Rat234-D1Rat228)/Rar with AT University of Colorado Denver, Colorado congenic Unknown 1 41225047 133567105 1 - by flanking markers 1 140507063 140507239 1 - by flanking markers 1 139523928 139524104 1 - by flanking markers 1 131763437 131763614 1 - by flanking markers RRID:RGD_2317827 2317891 SHR-Chr 6MWF/Rkb SHR/FubRkb male was crossed with female MWF/FubRkb to get F1 animals which in turn were backcrossed with female SHR/FubRkb, this was repeated for 7 generations, tested by sequential marker-assisted backcrossing Department of Clinical Pharmacology and Toxicology, Charite-Universitatsmedizin Berlin, Berlin, Germany consomic Unknown RRID:RGD_2317891 2324631 DA.E3-(D4Wox49-D4Got136)/Rhd This congenic strain was obtained by the conventional backcross breeding to the parental DA strain with the negative selection of all known Pia QTLs and positive selection of microsatellite markers. Medical Inflammation Research, Karolinska Institutet, Stockholm, Sweden. congenic Unknown Clec4a3 1359528 4 159060677 160528447 1 - by flanking markers 4 222438489 223964695 1 - by flanking markers 4 155414290 156945571 1 - by flanking markers 4 155828194 157232313 1 - by flanking markers RRID:RGD_2324631 2325143 SHR/NHsdMco Spontaneously Hypertensive Rat SHR strain obtained from Harlan Sprague-Dawley (Indianapolis, IN) and maintained at University of Toledo, College of Medicine (Medical College of Ohio), Toledo, Ohio. University of Toledo, College of Medicine (Medical College of Ohio), Toledo, Ohio. inbred Unknown RRID:RGD_2325143 2325145 LEW/CrlMco Lewis These were obtained from Charles River and maintained at University of Toledo, College of Medicine (Medical College of Ohio), Toledo, Ohio. University of Toledo, College of Medicine (Medical College of Ohio), Toledo, Ohio. inbred Unknown RRID:RGD_2325145 2325146 MNS/NMco Milan normotensive strain These were originally obtained from Veterinary Resource Branch, National Institutes of Health (Bethesda, MD) and maintained at University of Toledo, College of Medicine (Medical College of Ohio), Toledo, Ohio. University of Toledo, College of Medicine (Medical College of Ohio), Toledo, Ohio. inbred Unknown RRID:RGD_2325146 2325202 SS/JrSeac Dahl Salt-Sensitive Substrain of Dahl SS, from a Sprague-Dawley outbred colony, selected for sensitivity to salt-induced hypertension developed at Kyudo Co.,Ltd (http://www.kyudo.co.jp/) to Seac Yoshitomi, LTD Japan, now maintained at NBRP National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio- Hypertension RRID:RGD_2325202 2325206 LEW/Seac Substrain of LEW, from Dr Margaret Lewis from Wistar stock in early 1950s to Seac Yoshitomi, LTD Japan Seac Yoshitomi, LTD Japan inbred Unknown RRID:RGD_2325206 2325209 SHRSP/Hos Substrain of SHRSP purchased from Sankyo Lab Service, Japan. Sankyo Lab Service, Japan. inbred Unknown RRID:RGD_2325209 2325724 PVG.LEW-(D1Rat270-D1Rat68)/Kini 63-Mb fragment was selectively transferred from LEW.1AV1 to PVG.1AV1 Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 1 130290073 193070197 1 - by flanking markers 1 136616460 212591221 1 - by flanking markers 1 135611773 205603226 1 - by flanking markers 1 128593600 188377506 1 - by flanking markers RRID:RGD_2325724 2325754 SD-Pax6Sey/Mce Autosomal dominant mutation that arose spontaneously in SD rats. Genomic DNA analysis from mutants revealed a single base(G) insertion in the exon generating a novel 5' donor splice site. This led to the internal a 602-bp deletion of Pax6 mRNA. Department of Ophthalmology, Okayama University Medical School, Okayama, Japan mutant Unknown Pax6|Pax6Sey 3258|737688 3 91127605 91149178 1 - by flanking markers 3 102320059 102348223 1 - by flanking markers 3 95700241 95728682 1 - by flanking markers 3 92128772 92157022 1 - by flanking markers RRID:RGD_2325754 2325773 WKY.LEW-(D13Arb15-D13Rat58)/Tja Segment of interest from chr 13 of LEW/SsNHsd was introgressed into WKY/NCrl Imperial College, London, UK congenic Unknown 13 71116479 96441728 1 - by flanking markers 13 78673431 103987907 1 - by flanking markers 13 73748382 98985851 1 - by flanking markers 13 68269576 92436175 1 - by flanking markers RRID:RGD_2325773 2325774 WKY.LEW-(D13Arb10-D13Arb15)(D16Rat88-D16Rat40)/Tja WKY.LEW-(D13Arb10-D13Arb15) were crossed with WKY.LEW-(D16Rat88-D16Rat40), the F1 were backcrossed to WKY.LEW-(D13Arb10-D13Arb15) and then the offsprings were intercrossed Imperial College, London, UK, Rat Resource and Research Center congenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26) RRID:RRRC_00707 2325796 SS.LEW-(D3Rat52-D3Chm57)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D3Rat52-D3Rat130)/Ayd Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 3 14051872 24716931 1 - by flanking markers 3 19410399 34290625 1 - by flanking markers 3 14090411 29084626 1 - by flanking markers 3 18311454 28441896 1 - by flanking markers RRID:RGD_2325796 2325798 SS.LEW-(D10Got112-Igfbp4)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Rat27-Igfbp4)/Ayd Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown Igfbp4 2875 10 79857808 87834315 1 - by flanking markers 10 78816241 86759484 1 - by flanking markers 10 78970279 86962563 1 - by flanking markers 10 76246085 84007272 1 - by flanking markers RRID:RGD_2325798 2325801 SS.LEW-(D16Chm36-D16Mit2)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D16Rat12-D16Chm23)/Ayd Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 16 890512 4304517 1 - by flanking markers 16 1604056 5038806 1 - by flanking markers 16 1619835 5098704 1 - by flanking markers 16 903314 4227730 1 - by flanking markers RRID:RGD_2325801 2325803 SS.LEW-(D16Rat112-D16Chm60)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D16Rat12-D16Chm23)/Ayd Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 16 64718 3165043 1 - by flanking markers 16 773329 3491557 1 - by flanking markers 16 778415 3525217 1 - by flanking markers 16 110590 3080679 1 - by flanking markers RRID:RGD_2325803 4107048 SS.SR-(D7Rat16-D7Rat189)/Jr Congenic substrain derived by crossing the congenic strain SS.SR-Cyp11b1/Jr to SS/Jr to isolate which contains a smaller SR/Jr derived chromosome 7 segment Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 7 108647236 120385575 1 - by flanking markers 7 112143411 123228091 1 - by flanking markers 7 112204378 123243402 1 - by flanking markers 7 102920123 113526566 1 - by flanking markers RRID:RGD_4107048 4107052 SS.SR-(D7Rat16-D7Mgh5)/Jr Congenic substrain derived by crossing the congenic strain SS.SR-Cyp11b1/Jr to SS/Jr to isolate which contains a smaller SR/Jr derived chromosome 7 segment Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 7 108647236 115820414 1 - by flanking markers 7 112143411 119125830 1 - by flanking markers 7 112204378 119131068 1 - by flanking markers 7 102920123 109483487 1 - by flanking markers RRID:RGD_4107052 4107055 SS.SR-(D7Rat16-D7Rat176)/Jr Congenic substrain derived by crossing the congenic strain SS.SR-Cyp11b1/Jr to SS/Jr to isolate which contains a smaller SR/Jr derived chromosome 7 segment Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 7 108647236 111200952 1 - by flanking markers 7 112143411 114641749 1 - by flanking markers 7 112204378 114708307 1 - by flanking markers 7 102920123 105399458 1 - by flanking markers RRID:RGD_4107055 4107057 SS.SR-(D7Mco7-D7Rat81)/Jr Congenic substrain derived by crossing the congenic strain SS.SR-Cyp11b1/Jr to SS/Jr to isolate which contains a smaller SR/Jr derived chromosome 7 segment Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 7 112979256 129500555 1 - by flanking markers 7 116059683 131926277 1 - by flanking markers 7 132252091 132252361 1 - by flanking markers 7 122220558 122220831 1 - by flanking markers RRID:RGD_4107057 4107063 SS.LEW-(D1Uia8-D1Rat124)/Mco A sub-congenic strain derived from SS.LEW-(D1Rat268-D1Got35)/Jr contributing to the introgressed LEW allele Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown RRID:RGD_4107063 4107065 SS.LEW-(D1Uia8-D1Rat213)/Mco A sub-congenic strain derived from SS.LEW-(D1Rat268-D1Got35)/Jr contributing to the introgressed LEW allele Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio congenic Unknown 1 81548753 81548909 1 - by flanking markers 1 84537073 84537228 1 - by flanking markers 1 83282659 83282814 1 - by flanking markers 1 81777564 81777720 1 - by flanking markers RRID:RGD_4107065 4139872 SS-Nckap5em2Mcwi This strain was produced by injecting ZFNs targeting the sequence ctctgaaccttcaactttcagatactgatgacaatgaa into SS/JrHsdMcwi rat embryos. The resulting mutation is a 4-bp frameshift deletion in exon 6. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Nckap5em2Mcwi 4139862 13 38444115 39275959 1 - by flanking markers 13 47369687 48273649 1 - by flanking markers 13 42265875 43049232 1 - by flanking markers 13 37369948 38283257 1 - by flanking markers RRID:RGD_4139872 4139873 SS-Rag1em2Mcwi This strain was produced by injecting ZFNs targeting the sequence gtctactgcccaaggaatgtgaccgtggagtggca into SS/JrHsdMcwi rat embryos. The resulting mutation is a 17-bp frameshift deletion in exon1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Rag1em2Mcwi 4139866 3 86780782 86791878 1 - by flanking markers 3 97866048 97877145 1 - by flanking markers 3 91206394 91217491 1 - by flanking markers 3 87917061 87928158 1 - by flanking markers RRID:RGD_4139873 4139874 SS-Ets1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence aacccatgtccgggattgggtgatgtgggctgtgaatgag into SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp frameshift deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ets1em1Mcwi 4139856 8 32481694 32545237 1 - by flanking markers 8 33798598 33921593 1 - by flanking markers 8 33756634 33879625 1 - by flanking markers 8 31045909 31168010 1 - by flanking markers RRID:RGD_4139874 4139875 FHH-Chr 1BN-Sorcs1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence ataaacctttcccaggatacattgacccggattct into FHH-Chr 1BN/Mcwi embryos. The resulting mutation is a 14-bp frameshift deletion mutation in exon 20. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Sorcs1em1Mcwi 4139864 1 255767411 256279565 1 - by flanking markers 1 277404996 277912261 1 - by flanking markers 1 269965824 270473097 1 - by flanking markers 1 249080662 249594520 1 - by flanking markers RRID:RGD_4139875 4139877 FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CACCAAAACTTCTCCTCCCACTACCGGGCCACCATTGGT into FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi rat embryos. The resulting mutation is a 1-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Rab38em1Mcwi 4139867 1 144783919 144864573 1 - by flanking markers 1 158385888 158466621 1 - by flanking markers 1 152072716 152153449 1 - by flanking markers 1 142182566 142262923 1 - by flanking markers RRID:RGD_4139877 4139878 SS-Mmp2em2Mcwi This strain was produced by injecting ZFNs targeting the sequence aaccacaaccaactacgatgatgaccggaagtggggc into SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Mmp2em2Mcwi 4139869 19 15246036 15275061 1 - by flanking markers 19 26629728 26658966 1 - by flanking markers 19 15542771 15570589 1 - by flanking markers 19 14154657 14182870 1 - by flanking markers RRID:RGD_4139878 4139879 SS-Nckap5em1Mcwi This strain was produced by injecting ZFNs targeting the sequence ctctgaaccttcaactttcagatactgatgacaatgaa into SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 6. PhysGen Knockouts mutant Extinct Nckap5em1Mcwi 4139859 13 38444115 39275959 1 - by flanking markers 13 47369687 48273649 1 - by flanking markers 13 42265875 43049232 1 - by flanking markers 13 37369948 38283257 1 - by flanking markers RRID:RGD_4139879 4139880 SS-Renem1Mcwi This strain was produced by injecting ZFNs targeting the sequence acccttcatgctggccaagtttgacggggttctgggcatg into SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 5. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2017-01-26) Renem1Mcwi 4139863 13 46262936 46275213 1 - by flanking markers 13 55555583 55566812 1 - by flanking markers 13 50502724 50513953 1 - by flanking markers 13 44796260 44807491 1 - by flanking markers RRID:RGD_4139880 4139881 SS-Nckap5em3Mcwi This strain was produced by injecting ZFNs targeting the sequence ctctgaaccttcaactttcagatactgatgacaatgaa into SS/JrHsdMcwi rat embryos. The resulting mutation is an 11-bp frameshift deletion in exon 6. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Nckap5em3Mcwi 4139861 13 38444115 39275959 1 - by flanking markers 13 47369687 48273649 1 - by flanking markers 13 42265875 43049232 1 - by flanking markers 13 37369948 38283257 1 - by flanking markers RRID:RGD_4139881 4139882 SS-Nppaem4Mcwi This strain was produced by injecting ZFNs targeting the sequence gcctccgcaggccctgagcgagcagaccgatgaagcgggg into SS/JrHsdMcwi rat embryos. The resulting mutation is a 22-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Nppaem4Mcwi 4139857 5 165074518 165075827 1 - by flanking markers 5 168466309 168467618 1 - by flanking markers 5 164808407 164809716 1 - by flanking markers 5 158429042 158430351 1 - by flanking markers RRID:RGD_4139882 4139883 SS-Nox4em2Mcwi This strain was produced by injecting ZFNs targeting the sequence ggttacagcttctacctatgcaataaggtaagggtc into SS/JrHsdMcwi rat embryos. The resulting mutation is an 8-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2017-01-26) Nox4em2Mcwi 4139868 1 143415816 143603554 1 - by flanking markers 1 157106652 157285107 1 - by flanking markers 1 150796359 150976186 1 - by flanking markers 1 140900886 141078844 1 - by flanking markers RRID:RGD_4139883 4139884 SS-Rag1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence gtctactgcccaaggaatgtgaccgtggagtggca into SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp frameshift deletion in exon1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Rag1em1Mcwi 4139865 3 86780782 86791878 1 - by flanking markers 3 97866048 97877145 1 - by flanking markers 3 91206394 91217491 1 - by flanking markers 3 87917061 87928158 1 - by flanking markers RRID:RGD_4139884 4139885 SS-Sh2b3em1Mcwi This strain was produced by injecting ZFNs targeting the sequence ctcccccatcccacttgaatgtggagcagcctgtg into SS/JrHsdMcwi rat embryos. The resulting mutation is an in-frame 6-bp deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Sh2b3em1Mcwi 4139858 12 35954679 35958446 1 - by flanking markers 12 42132947 42136714 1 - by flanking markers 12 40261990 40265757 1 - by flanking markers 12 34749849 34753616 1 - by flanking markers RRID:RGD_4139885 4139889 BHD/Dspe Birt-Hogg-Dube rat A rat showing hereditary renal cell carcinoma was found in a Jcl:SD rat colony and named Nihon rat. In this rat strain mutation was identified as an insertion of a cytosine (C) in a C tract within exon 3 of Flcn . This germline mutation results in a frameshift and produces a stop codon 26 amino-acids downstream. Thereafter they have been maintained at Dainippon Sumitomo Pharma Co., Ltd. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo (as of 2018-06-06) Flcn 735088 RRID:RGD_4139889 4139890 TT/Sgn Rats with bilateral small testes were found in a Wistar-Imamichi derived inbred strain in 1986 at the Institute for Animal Reproduction. TT was established from these mutant rats as known as aspermia rats. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Fkbp6 1308926 12 22474002 22544784 1 - by flanking markers 12 26363264 26435311 1 - by flanking markers 12 24365941 24438088 1 - by flanking markers 12 21318251 21390350 1 - by flanking markers RRID:RGD_4139890 4139891 F344-Chr 3SDT/Nyo This consomic strain carries Chromosome 3 of SDT/Jcl on F344/NSlc background. National BioResource Project for the Rat in Japan consomic Cryopreserved Embryo Diabetes Obesity RRID:RGD_4139891 4139892 ALD/Hyo acid lipase deficiency rat In a colony of Donryu rats, Yoshida found a male rat showing hepatomegaly and splenomegaly in 1981. These mutant rats were transferred to Kagoshima University and maintained in heterozygous condition so far. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo Metabolism Lipam1Hyo 150519893 RRID:RGD_4139892 4140402 W-Tg(Gh1as)Nibs The construct which contains of rat growth hormone (Gh1) promoter, 4 copies of thyroid hormone response element (TRE), and antisense sequences for rat Gh1 cDNA was injected into Jcl:Wistar embryo (Matsumoto, 1993). This transgenic rat was established at NT Science in 1992, and transferred to Japan Bio Science Laboratory Co., Ltd. in 2003. This strain has been maintained at Nagasaki University Graduate School of Biomedical Science. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_4140402 4140403 SD-Tg(Eno2-ATXN3*64Q)29Kakiz Background strain is Slc:SD. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Neurobiology RRID:RGD_4140403 4140404 ODS-Gulood/od/ShiJcl Osteogenic disorder Shionagi rat Dr. Susumu Makino and his colleagues found several animals that had gait abnormalities among Wistar rats maintained at Shionogi Co. They named these animals osteogenic disorder (OD) rats because they exhibited prominent bone and joint abnormalities and systemic bleeding. Subsequent studies revealed that these symptoms were derived from an ascorbic acid (vitamin C) deficiency arising from defective gulonolactone oxidase (GLO) activity. This characteristic was confirmed to be the result of a mutation involving the autosomal single recessive gene od. Scurvy due to L-gulonolactone oxidase deficincy; phenotype normalizes if supplied with ascorbic acid 300mg/kg/d. od/od rats are more susceptible to dental caries as compared with +/+ rats, in only amoun parous females. CLEA Japan, Inc inbred Live Animals (as of 2021-04-29) Gulood 126848761 RRID:RGD_4140404 4140405 LEXF6A/Stm The LEXF/FXLE RI strain set has been established by Shisa et al at Saitama Cancer Center Research Institute since 1985. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo RRID:RGD_4140405 4140406 SHRSP.WKY-(D1Wox29-D1Arb21)/IzmDmcr To establish this congenic strain, the genetic region in which contains a QTL that is responsible for hypertension in SPRSP was introgressed from WKY/Izm to SHRSP/Izm by repeated backcrossing following sib-mating. This congenic strain was established to cover the QTL region between D1Wox29 and D1Arb21. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo 1 124614679 187092492 1 - by flanking markers 1 131822204 206277202 1 - by flanking markers 1 130779148 199254774 1 - by flanking markers 1 123350408 182418476 1 - by flanking markers RRID:RGD_4140406 4140407 SDT.BN-Gluco13/Nyo The Gluco13 (Gisdt1) region of BN/Seac was transferred onto the genetic background of SDT/Jcl strain. Established by speed congenic method since 2003 and afterwards maintained by sib mating (N9F6, May 2010) Please refer to STD.BN-Gluco14/Nyo (NBRP No. 0602). National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity RRID:RGD_4140407 4140408 LEXF8C/Stm The LEXF/FXLE RI strain set has been established by Shisa et al at Saitama Cancer Center Research Institute since 1985. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo RRID:RGD_4140408 4140409 COP-Chr 16DA/McoRrrc Transfer of the DA-rat chromosome 16 (RNO16) into the COP-rat background University of Toledo College of Medicine, Toledo, Ohio consomic Unknown RRID:RGD_4140409 4140410 SD-Tg(Eno2-ATXN3*64Q)16Kakiz Background strain is Slc:SD. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Neurobiology RRID:RGD_4140410 4140411 SDT.BN-Gluco14/Nyo The Gluco14 (Gisdt2) region of BN/Seac was transferred onto the genetic background of SDT/Jcl strain. Established by speed congenic method since 2003 and afterwards maintained by sib mating (N10F6, May 2010) Please refer to STD.BN- Gluco13/Nyo (NBRP No. 0601). National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity RRID:RGD_4140411 4140412 LEXF1D/Stm The LEXF/FXLE RI strain set has been established by Shisa et al at Saitama Cancer Center Research Institute since 1985. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo RRID:RGD_4140412 4140413 LEXF1B/Stm The LEXF/FXLE RI strain set has been established by Shisa et al at Saitama Cancer Center Research Institute since 1985. National BioResource Project for the Rat in Japan recombinant_inbred Cryopreserved Embryo RRID:RGD_4140413 4140414 WKY.SHRSP-(D1Wox29-D1Arb21)/IzmDmcr To establish this congenic strain, the genetic region in which contains a QTL that is responsible for hypertension in SPRSP was introgressed from SHRSP/Izm to WKY/Izm by repeated backcrossing following sib-mating. This congenic strain was established to cover the QTL region between D1Wox29 and D1Arb21. National BioResource Project for the Rat in Japan congenic Unknown 1 124614679 187092492 1 - by flanking markers 1 131822204 206277202 1 - by flanking markers 1 130779148 199254774 1 - by flanking markers 1 123350408 182418476 1 - by flanking markers RRID:RGD_4140414 4140415 TRMRC/Kyo The coisogenic control strain for the TRMR strain (NBRP No.0016). National BioResource Project for the Rat in Japan coisogenic Live Animals; Cryopreserved Sperm RRID:RGD_4140415 4140416 SD-Tg(Eno2-Vcp)16Kakiz This transgenic strain was generated by microinjection into Slc:SD fertilized eggs. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Neurobiology RRID:RGD_4140416 4140469 F344-Kmch/NSlc Komachi from NBRP National BioResource Project for the Rat in Japan mutant Unknown RRID:RGD_4140469 4142540 SHR.WKY-(D4Rat10-D4Rat15)/IzmTkyo This congenic strain was established by crossing between WKY/Izm and SHR/Izm in 2001. Heterozygous consomic rats were established in 2004, homozygous consomic rats were established in 2005, and homozygous congenic rats were established by crossing among consomic heterozygous rats in 2009. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio Hypertension 4 26280781 47890193 1 - by flanking markers 4 26659360 48448808 1 - by flanking markers 4 26753655 48656399 1 - by flanking markers 4 29593287 50119996 1 - by flanking markers RRID:RGD_4142540 4142541 W-Tg(Tek-GFP)1Soh This transgenic strain was generated by microinjection into fertilized oocytes of Wistar rats. The vector containing the Tek/GFP plasmid (pSP14/15.t2hgfpPan5) was a gift from Dr. TN Sato of University of Texas Southwestern Medical Center at Dallas. The transgene was excised from the plasmid vector by Sal I digestion. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RGD_4142541 4142542 BN.SDT-Gluco14/Nyo The Gluco14 region, one of the significant QTL for glucose intolerance of SDT/Jcl was transferred onto the genetic background of BN/Seac strain. Established by speed congenic method since 2003 and afterwards maintained by sib mating (N6F10, July 2010) Please refer to STD.BN-Gluco14/Nyo. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity RRID:RGD_4142542 4142543 BN.SDT-Gluco13/Nyo The Gluco13 region, one of the significant QTL for glucose intolerance of SDT/Jcl was transferred onto the genetic background of BN/Seac strain. Established by speed congenic method since 2003 and afterwards maintained by sib mating (N6F11, July 2010). Please refer to STD.BN-Gluco13/Nyo. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Diabetes Obesity RRID:RGD_4142543 4142544 WKY/Kiha A WKY rat showing higher serum adiponectin concentration was found in Department of Pathology, Kinki University School of Medicine. In 1974, this strain was transferred from Dr. Okamoto to Kyoto University. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo RRID:RGD_4142544 4142545 SHR.WKY-(D3Rat108-D3Rat166)/IzmTkyo This congenic strain was established by crossing between WKY/Izm and SHR/Izm in 2001. Heterozygous consomic rats were established in 2004, homozygous consomic rats were established in 2005, and homozygous congenic rats were established by crossing among consomic heterozygous rats in 2009. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio Hypertension 3 59676608 101359980 1 - by flanking markers 3 70419858 113470358 1 - by flanking markers 3 63849481 106900596 1 - by flanking markers 3 61934079 102200699 1 - by flanking markers RRID:RGD_4142545 4142546 AMI/Tj Rats which showed a dental mutation such as morphological abnormalities of the teeth were found in the SHR-SP rats at Daiichi Seiyaku, Co., Ltd. in 1981. Transferred to Tokushima University in 2003. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo Dentistry RRID:RGD_4142546 4142547 SHR.WKY-(D4Wox27-D4Rat11)/IzmTkyo This congenic strain was established by crossing between WKY/Izm and SHR/Izm in 2001. Heterozygous consomic rats were established in 2004, homozygous consomic rats were established in 2005, and homozygous congenic rats were established by crossing among consomic heterozygous rats in 2009. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio Hypertension 4 460493 33407710 1 - by flanking markers 4 3096322 34240072 1 - by flanking markers 4 3044017 34379894 1 - by flanking markers 4 5218294 36405277 1 - by flanking markers RRID:RGD_4142547 4142548 SHR.WKY-(D4Wox27-D4Rat10)/IzmTkyo This congenic strain was established by crossing between WKY/Izm and SHR/Izm in 2001. Heterozygous consomic rats were established in 2004, homozygous consomic rats were established in 2005, and homozygous congenic rats were established by crossing among consomic heterozygous rats in 2009. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio Hypertension 4 460493 26280949 1 - by flanking markers 4 3096322 26659527 1 - by flanking markers 4 3044017 26753822 1 - by flanking markers 4 5218294 29593455 1 - by flanking markers RRID:RGD_4142548 4142549 SHR.WKY-(D4Wox27-D4Rat4)/IzmTkyo This congenic strain was established by crossing between WKY/Izm and SHR/Izm in 2001. Heterozygous consomic rats were established in 2004, homozygous consomic rats were established in 2005, and homozygous congenic rats were established by crossing among consomic heterozygous rats in 2009. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio Hypertension 4 460493 3237361 1 - by flanking markers 4 3096322 4400584 1 - by flanking markers 4 3044017 4364885 1 - by flanking markers 4 5218294 7935781 1 - by flanking markers RRID:RGD_4142549 4142550 SHR.WKY-(D4Rat101-D4Rat15)/IzmTkyo This congenic strain was established by crossing between WKY/Izm and SHR/Izm in 2001. Heterozygous consomic rats were established in 2004, homozygous consomic rats were established in 2005, and homozygous congenic rats were established by crossing among consomic heterozygous rats in 2009. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio Hypertension 4 46605924 47890193 1 - by flanking markers 4 46704280 48448808 1 - by flanking markers 4 46898276 48656399 1 - by flanking markers 4 49131906 50119996 1 - by flanking markers RRID:RGD_4142550 4142799 LEW.SS-(D2Uia5-D2Rat143)/Ayd LEW/Crlc and SS/Jr were backcrossed for 5 generations, then BC5 rat was mated with SS/Jr to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 2 13909383 106236206 1 - by flanking markers 2 13186164 125885146 1 - by flanking markers 2 13328947 106156987 1 - by flanking markers 2 15575840 103519040 1 - by flanking markers RRID:RGD_4142799 4142800 LEW.SS-(D18Chm31-D18Mit8)/Ayd LEW/Crlc and SS/Jr were backcrossed for 5 generations, then BC5 rat was mated with SS/Jr to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 2848113 62229060 1 - by flanking markers 18 2761846 61177004 1 - by flanking markers 18 2745212 61985812 1 - by flanking markers 18 59796478 59796643 1 - by flanking markers RRID:RGD_4142800 4143165 SD-Tg(Aqp5-GFP)ZboroRrrc Aqp5EGFP This rat model was developed by perivitelline injection of one cell SD embryos with packaged lentiviral particles containing the pFUGW vector containing the Aqp5 promoter and the EGFP gene. Resulting transgenic founders with mated to wild-type SD rats and heterozygous offspring were obtained. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm Aqp5 2144 RRID:RRRC_00427 4143456 BN.GK-(D2Wox30-D2Wox68)/Ox This congenic strain is derived from GK rats which were from a colony in Paris (CNRS) obtained in 1995. BN rats were initially obtained from Charles River Laboratories, Margate, UK. The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK congenic Unknown RRID:RGD_4143456 4143457 BN.GK-(D2Rat40-D2Wox35)/Ox This congenic strain is derived from GK rats which were from a colony in Paris (CNRS) obtained in 1995. BN rats were initially obtained from Charles River Laboratories, Margate, UK. The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK congenic Unknown 2 163154227 163154358 1 - by flanking markers 2 189197858 189197988 1 - by flanking markers 2 169852670 244719662 1 - by flanking markers 2 157142078 157142209 1 - by flanking markers RRID:RGD_4143457 4143458 BN.GK-(D2Wox49-D2Rat70)/Ox This congenic strain is derived from GK rats which were from a colony in Paris (CNRS) obtained in 1995. BN rats were initially obtained from Charles River Laboratories, Margate, UK. The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK congenic Unknown 2 191000085 254933362 1 - by flanking markers 2 217822782 281850471 1 - by flanking markers 2 198335799 263179188 1 - by flanking markers 2 183756199 245889826 1 - by flanking markers RRID:RGD_4143458 4143459 BN.GK-(D2Rat40-D2Got149)/Ox This congenic strain is derived from GK rats which were from a colony in Paris (CNRS) obtained in 1995. BN rats were initially obtained from Charles River Laboratories, Margate, UK. The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK congenic Unknown 2 163154227 222343164 1 - by flanking markers 2 189197858 248391122 1 - by flanking markers 2 169852670 229036415 1 - by flanking markers 2 157142078 213653017 1 - by flanking markers RRID:RGD_4143459 4145088 SS.BN-(D6Rat119-D6Arb3)/Mcwi SS/JrHsdMcwi were crossed with SS-6BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 6 111239053 138260635 1 - by flanking markers 6 120420333 147057860 1 - by flanking markers 6 111134524 138065254 1 - by flanking markers 6 106752656 132339866 1 - by flanking markers RRID:RGD_4145088 4145089 SS.BN-(D6Rat149-D6Rat18)/Mcwi SS/JrHsdMcwi were crossed with SS-6BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 6 7161389 93374504 1 - by flanking markers 6 6959479 103168177 1 - by flanking markers 6 7009971 93706327 1 - by flanking markers 6 10894415 89763029 1 - by flanking markers RRID:RGD_4145089 4145090 SS.BN-(D6Rat149-D6Got171)/Mcwi SS/JrHsdMcwi were crossed with SS-6BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 6 7161389 123782965 1 - by flanking markers 6 6959479 132827005 1 - by flanking markers 6 7009971 123598338 1 - by flanking markers 6 10894415 118863044 1 - by flanking markers RRID:RGD_4145090 4145091 SS.BN-(D6Rat149-D6Arb3)/Mcwi SS/JrHsdMcwi were crossed with SS-6BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 6 7161389 138260635 1 - by flanking markers 6 6959479 147057860 1 - by flanking markers 6 7009971 138065254 1 - by flanking markers 6 10894415 132339866 1 - by flanking markers RRID:RGD_4145091 4145374 ACI.FHH-(D1Mit18-D1Rat90)(D14Rat98-D14Hmgc18)/Mcwi Congenic strain developed by crossing ACI.FHH-(D1Rat74-D1Rat90)/Eur (Rf-1a) males to ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/EurMcwi (Rf-1a+4) double congenic females Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown RRID:RGD_4145374 4889411 SHRSP.WKY-(D1Smu13-D1Wox33)/Izm About 100 male pups were obtained by breeding SHRSP/Izm and SHRSP.WKY-(D1Smu13-D1Arb21)/Izm; one pup that had the right recombination was found and backcrossed to the parental strain to get the hetrozygotes, which were then mated brother-sister to get the desired congenic strain Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio- Hypertension 1;2 160754901;198300754 160755065;198300855 1 - by flanking markers;1 - by flanking markers 2;1 224991853;173074640 224991955;174300801 1 - by flanking markers;1 - by flanking markers 1 166884926 166885141 1 - by flanking markers 1 156170341 156170557 1 - by flanking markers RRID:RGD_4889411 4889414 WKY.SHRSP-(D1Rat171-D1Wox33)/Izm About 100 male pups were obtained by breeding SHRSP/Izm and WKY.SHRSP-(D1Smu13-D1Smu11)/Izm; one pup that had the right recombination was found and backcrossed to the parental strain to get the hetrozygotes, which were then mated brother-sister to get the desired congenic strain Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio-Hypertension 1;2 158964262;198300754 160755065;198300855 1 - by flanking markers;1 - by flanking markers 1;2 172767534;224991853 174300801;224991955 1 - by flanking markers;1 - by flanking markers 1 166577232 166577467 1 - by flanking markers 1 155866514 155866750 1 - by flanking markers RRID:RGD_4889414 4889450 DA.PVG.1AV1-(D1Rat248-D1Rat10)/Kini DA/ZtmKini females were mated with PVG.1AV1/Kini males that had PVG allele within the Eae29 region, one breeding pair from N7 generation was intercrossed to give homozygous congenic that had PVG allele from the begining of chr1 to D1Rat10 (approximately 25.4 Mb) Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 1 6253932 25271177 1 - by flanking markers 1 7306802 86917075 1 - by flanking markers 1 5655772 85706974 1 - by flanking markers 1 5925877 24697545 1 - by flanking markers RRID:RGD_4889450 4889464 GK/Ox Original breeders are from a colony in Paris (CNRS URA 307, Paris, France) which were obtained in 1995 and since then bred locally in Oxford, UK The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK inbred Unknown RRID:RGD_4889464 4889499 CDS-Chr 4CDR/Ygl Homozygous male CDS/Ygl were bred with CDR/Ygl females; F1 heterozygotes were mated with parental female CDS/Ygl and backcrossed again for 8 times till the allele was fixed Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel consomic Unknown RRID:RGD_4889499 4889817 SBN-Chr 1SBH/Ygl Homozygous male SBN/Ygl were bred with SBH/Ygl females; F1 heterozygotes were mated with parental female SBN/Ygl and backcrossed again for 8 times till the allele was fixed Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel consomic Unknown RRID:RGD_4889817 4889820 SBH-Chr 1SBN/Ygl Homozygous male SBH/Ygl were bred with SBN/Ygl females; F1 heterozygotes were mated with parental female SBH/Ygl and backcrossed again for 8 times till the allele was fixed Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel consomic Unknown RRID:RGD_4889820 4889822 SBN-Chr 17SBH/Ygl Homozygous male SBN/Ygl were bred with SBH/Ygl females; F1 heterozygotes were mated with parental female SBN/Ygl and backcrossed again for 8 times till the allele was fixed Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel consomic Unknown RRID:RGD_4889822 4889875 SBH-Chr 2SBN/Ygl Homozygous male SBH/Ygl were bred with SBN/Ygl females; F1 heterozygotes were mated with parental female SBH/Ygl and backcrossed again for 8 times till the allele was fixed Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel consomic Unknown RRID:RGD_4889875 4889877 SBH-Chr 20SBN/Ygl Homozygous male SBH/Ygl were bred with SBN/Ygl females; F1 heterozygotes were mated with parental female SBH/Ygl and backcrossed again for 8 times till the allele was fixed Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel consomic Unknown RRID:RGD_4889877 4889879 SBH-Chr XSBN/Ygl Homozygous male SBH/Ygl were bred with SBN/Ygl females; F1 heterozygotes were mated with parental female SBH/Ygl and backcrossed again for 8 times till the allele was fixed Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel consomic Unknown RRID:RGD_4889879 4889882 SBH-Chr 17SBN/Ygl Homozygous male SBH/Ygl were bred with SBN/Ygl females; F1 heterozygotes were mated with parental female SBH/Ygl and backcrossed again for 8 times till the allele was fixed Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel consomic Unknown RRID:RGD_4889882 4889890 DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini DA/ZtmKini females were mated with PVG.1AV1/Kini males and offsprings were selected for the PVG allele of interest, one breeding pair from N8 generation was intercrossed to give homozygous congenic that had PVG allele from D17Rat8 to D17Rat37 Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Immunology 17 27618789 75802944 1 - by flanking markers 17 25486196 69844594 1 - by flanking markers 17 23522321 68114865 1 - by flanking markers 17 21782841 64759263 1 - by flanking markers RRID:RGD_4889890 4891048 SS.LEW-(D7Rat73-D7Rat128)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown Avpr1a|Cyp11b1|Cyp11b2|Tac3|Trhr|Cox6c|Kcnv1|Kcns2|Nxph4|Cyp11b3 2185|2453|2454|3809|3904|620616|621264|621525|628723|727886 7 57326196 121524220 1 - by flanking markers 7 61044919 124236725 1 - by flanking markers 7 61047589 124246733 1 - by flanking markers 7 53612714 114528048 1 - by flanking markers RRID:RGD_4891048 4891051 LEW.SS-(D7Rat73-D7Rat128)/Ayd LEW/Crlc and SS/Jr were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown Avpr1a|Cyp11b1|Cyp11b2|Tac3|Trhr|Cox6c|Kcnv1|Kcns2|Nxph4|Cyp11b3 2185|2453|2454|3809|3904|620616|621264|621525|628723|727886 7 57326196 121524220 1 - by flanking markers 7 61044919 124236725 1 - by flanking markers 7 61047589 124246733 1 - by flanking markers 7 53612714 114528048 1 - by flanking markers RRID:RGD_4891051 4891103 WMI/EerRrrc WKY most immobile 3 pairs of WKY males and females with highest immobility and lowest climbing scores in the forced swim test were mated. Dept. of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Rat Resource and Research Center inbred Unknown RRID:RRRC_00973 4891107 WLI/EerRrrc WKY least immobile 3 pairs of WKY males and females with lowest immobility and highest climbing scores in the forced swim test were mated. Dept. of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Rat Resource and Research Center inbred Unknown RRID:RRRC_00967 4891165 Wig/Ymas wiggling These are congenic wiggling rats established by transferring the wiggling gene from Long-Evans Cinnamon (LEC) to Wistar King-Aptekman/Hokkaido (WKAH) strain Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan congenic Unknown RRID:RGD_4891165 4891380 SS.SR-(D9Mco95-D9Mco98)/Mco SS.SR-(D9Mco95-Resp18)/Mco was crossed with SS/Jr to generate F1 which were intercrossed to generate F2, these were genotyped using markers throughout 73140156-74554694 region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 80867159 80946065 1 - by flanking markers 9 81100315 81180041 1 - by flanking markers 9 75403227 75482161 1 - by flanking markers RRID:RGD_4891380 4891383 SS.SR-(D9Mco98-Resp18)/1Mco SS.SR-(D9Mco95-Resp18)/Mco was crossed with SS/Jr to generate F1 which were intercrossed to generate F2, these were genotyped using markers throughout 73140156-74554694 region Medical College of Ohio, Toledo, Ohio congenic Unknown Resp18 3555 9 74551809 74558151 1 - by flanking markers 9 80945872 82246695 1 - by flanking markers 9 81179848 82477136 1 - by flanking markers 9 75481963 76771824 1 - by flanking markers RRID:RGD_4891383 4891386 SS.SR-(D9Mco98-Resp18)/2Mco SS.SR-(D9Mco95-Resp18)/Mco was crossed with SS/Jr to generate F1 which were intercrossed to generate F2, these were genotyped using markers throughout 73140156-74554694 region Medical College of Ohio, Toledo, Ohio congenic Unknown Resp18 3555 9 74551809 74558151 1 - by flanking markers 9 80945872 82246695 1 - by flanking markers 9 81179848 82477136 1 - by flanking markers 9 75481963 76771824 1 - by flanking markers RRID:RGD_4891386 4891388 SS.SR-(D9Mco95-D9Mco100)/1Mco SS.SR-(D9Mco95-Resp18)/Mco was crossed with SS/Jr to generate F1 which were intercrossed to generate F2, these were genotyped using markers throughout 73140156-74554694 region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 80867159 81453493 1 - by flanking markers 9 81100315 81688944 1 - by flanking markers 9 75403227 75990271 1 - by flanking markers RRID:RGD_4891388 4891390 SS.SR-(D9Mco95-D9Mco100)/2Mco SS.SR-(D9Mco95-Resp18)/Mco was crossed with SS/Jr to generate F1 which were intercrossed to generate F2, these were genotyped using markers throughout 73140156-74554694 region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 80867159 81453493 1 - by flanking markers 9 81100315 81688944 1 - by flanking markers 9 75403227 75990271 1 - by flanking markers RRID:RGD_4891390 4891392 SS.SR-(D9Mco95-D9Mco102)/Mco SS.SR-(D9Mco95-Resp18)/Mco was crossed with SS/Jr to generate F1 which were intercrossed to generate F2, these were genotyped using markers throughout 73140156-74554694 region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 80867159 81641213 1 - by flanking markers 9 81100315 81878831 1 - by flanking markers 9 75403227 76175576 1 - by flanking markers RRID:RGD_4891392 4891394 SS.SR-(D9Mco101-Resp18)/Mco SS.SR-(D9Mco95-Resp18)/Mco was crossed with SS/Jr to generate F1 which were intercrossed to generate F2, these were genotyped using markers throughout 73140156-74554694 region Medical College of Ohio, Toledo, Ohio congenic Unknown Resp18 3555 9 74551809 74558151 1 - by flanking markers 9 81611825 82246695 1 - by flanking markers 9 81847677 82477136 1 - by flanking markers 9 76145766 76771824 1 - by flanking markers RRID:RGD_4891394 4891396 SS.SR-(D9Mco72-Resp18)/Mco SS.SR-(D9Mco95-Resp18)/Mco was crossed with SS/Jr to generate F1 which were intercrossed to generate F2, these were genotyped using markers throughout 73140156-74554694 region Medical College of Ohio, Toledo, Ohio congenic Unknown Resp18 3555 9 44842118 74558151 1 - by flanking markers 9 52352690 82246695 1 - by flanking markers 9 52686874 82477136 1 - by flanking markers 9 47902208 76771824 1 - by flanking markers RRID:RGD_4891396 4891400 SS.SR-(D9Mco14-Resp18)/1Mco SS.SR-(D9Mco95-Resp18)/Mco was crossed with SS/Jr to generate F1 which were intercrossed to generate F2, these were genotyped using markers throughout 73140156-74554694 region Medical College of Ohio, Toledo, Ohio congenic Unknown Resp18 3555 9 74436883 74558151 1 - by flanking markers 9 82125291 82246695 1 - by flanking markers 9 82356030 82477136 1 - by flanking markers 9 76650629 76771824 1 - by flanking markers RRID:RGD_4891400 4891402 SS.SR-(D9Mco14-Resp18)/2Mco SS.SR-(D9Mco95-Resp18)/Mco was crossed with SS/Jr to generate F1 which were intercrossed to generate F2, these were genotyped using markers throughout 73140156-74554694 region Medical College of Ohio, Toledo, Ohio congenic Unknown Resp18 3555 9 74436883 74558151 1 - by flanking markers 9 82125291 82246695 1 - by flanking markers 9 82356030 82477136 1 - by flanking markers 9 76650629 76771824 1 - by flanking markers RRID:RGD_4891402 4891404 SS.SR-(D9Mco14-Resp18)/3Mco SS.SR-(D9Mco95-Resp18)/Mco was crossed with SS/Jr to generate F1 which were intercrossed to generate F2, these were genotyped using markers throughout 73140156-74554694 region Medical College of Ohio, Toledo, Ohio congenic Unknown Resp18 3555 9 74436883 74558151 1 - by flanking markers 9 82125291 82246695 1 - by flanking markers 9 82356030 82477136 1 - by flanking markers 9 76650629 76771824 1 - by flanking markers RRID:RGD_4891404 4892563 WF.WKY-(D5Rat26-D5Uwm42)/Uwm WKY/NHsd rats were mated with WF/NHsd and the progeny was backcrossed to WF for 8-9 generations, selecting for Mcs5 region. University of Wisconsin-Madison congenic Unknown 5 119332868 153554465 1 - by flanking markers 5 121495621 156871691 1 - by flanking markers 5 117554114 153097789 1 - by flanking markers 5 113558156 146996127 1 - by flanking markers RRID:RGD_4892563 5130721 HXB1/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5130721 5131094 BN-Lx/CubPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California mutant Unknown RRID:RGD_5131094 5131095 BXH13/CubPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131095 5131097 BXH12/CubPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131097 5131099 BXH11/CubPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131099 5131101 BXH10/CubPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131101 5131104 BXH9/CubPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131104 5131106 BXH8/CubPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131106 5131108 BXH6/CubPrin Embryo-rederived from breeder stock BXH6/Cub provided by Dr. Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131108 5131110 BXH5/CubPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131110 5131113 HXB31/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131113 5131115 HXB29/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131115 5131118 HXB27/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131118 5131120 HXB26/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131120 5131122 HXB25/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131122 5131124 HXB23/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131124 5131126 HXB20/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131126 5131128 HXB17/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131128 5131130 HXB15/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131130 5131132 HXB13/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131132 5131134 HXB10/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained by Printz laboratory for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131134 5131136 HXB7/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131136 5131138 HXB4/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131138 5131140 HXB3/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131140 5131142 HXB2/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131142 5131144 HXB18/IpcvPrin Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained for over 20 generations and verified by PLS phenotyping and microsatellite genotyping. Dept. of Pharmacology, University of California, San Diego, La Jolla, California recombinant_inbred Unknown RRID:RGD_5131144 5131910 SS-Acad10em2Mcwi This strain was produced by injecting ZFNs targeting the sequence GAAAGCTGCCCACCTCATGgatgtgGCCGGAAACAAGGTGGGA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Acad10em2Mcwi 5131905 12 36070275 36075844 1 - by flanking markers 12 42285817 42328189 1 - by flanking markers 12 40417918 40460562 1 - by flanking markers 12 34901211 34943973 1 - by flanking markers RRID:RGD_5131910 5131911 SS-Alms1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CCCGCCTCCGACTCCGCCtccgtcCTCCCGGCACCAGTA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 17-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Alms1em1Mcwi 5131906 4 119846037 119946085 1 - by flanking markers 4 181947469 182048235 1 - by flanking markers 4 117371544 117472310 1 - by flanking markers 4 118125581 118226005 1 - by flanking markers RRID:RGD_5131911 5131912 SS-Aldh2em2Mcwi This strain was produced by injecting ZFNs targeting the sequence AACGGCAAGCCTTATGtcatcTCCTACCTGGTGGAT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Aldh2em2Mcwi 5131907 12 36081778 36116445 1 - by flanking markers 12 42334057 42366049 1 - by flanking markers 12 40466418 40498813 1 - by flanking markers 12 34949549 34982527 1 - by flanking markers RRID:RGD_5131912 5131920 SS-Apoeem8Mcwi This strain was produced by injecting ZFNs targeting the sequence CAGGCCCTGAACCGCttctggGATTACCTGCGCTGGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 24-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Extinct Apoeem8Mcwi 5131915 1 79003634 79006387 1 - by flanking markers 1 81878372 81882298 1 - by flanking markers 1 80612894 80616820 1 - by flanking markers 1 79353924 79357852 1 - by flanking markers RRID:RGD_5131920 5131921 SS-Apoeem7Mcwi This strain was produced by injecting ZFNs targeting the sequence CAGGCCCTGAACCGCttctggGATTACCTGCGCTGGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 15-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Extinct Apoeem7Mcwi 5131918 1 79003634 79006387 1 - by flanking markers 1 81878372 81882298 1 - by flanking markers 1 80612894 80616820 1 - by flanking markers 1 79353924 79357852 1 - by flanking markers RRID:RGD_5131921 5131922 SS-Cdh13em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTCACCCTGTGCGTCctgctgTCCCAGGTAGGGAATG into SS/JrHsdMcwi rat embryos. The resulting mutation is an 8-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Cdh13em1Mcwi 5131919 19 48507173 49575123 1 - by flanking markers 19 61621434 62720155 1 - by flanking markers 19 50848793 51971618 1 - by flanking markers 19 46349562 47387462 1 - by flanking markers RRID:RGD_5131922 5131932 SS-Cyp1a1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGGTAACCAACCCTAGGatacagAGAAAGATCCAGGAGGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 19-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Cyp1a1em1Mcwi 5131928 8 61462207 61468237 1 - by flanking markers 8 62249046 62255081 1 - by flanking markers 8 62472087 62478122 1 - by flanking markers 8 58096021 58102130 1 - by flanking markers RRID:RGD_5131932 5131933 SS-Cybaem1Mcwi This strain was produced by injecting ZFNs targeting the sequence CGAGTGGGCCATgtgggCCAACGAACAGGCGC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 36-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Cybaem1Mcwi 5131930 19 52713150 52721609 1 - by flanking markers 19 65959818 65967224 1 - by flanking markers 19 55249634 55257824 1 - by flanking markers 19 50487598 50495669 1 - by flanking markers RRID:RGD_5131933 5131934 SS-Cyp1a1em5Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGGTAACCAACCCTAGGatacagAGAAAGATCCAGGAGGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is an 8-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Cyp1a1em5Mcwi 5131929 8 61462207 61468237 1 - by flanking markers 8 62249046 62255081 1 - by flanking markers 8 62472087 62478122 1 - by flanking markers 8 58096021 58102130 1 - by flanking markers RRID:RGD_5131934 5131950 SS-Msraem3Mcwi This strain was produced by injecting ZFNs targeting the sequence CTCATCTTCGAAGGTCatcagcGCGGAGGAAGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is an 18-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Msraem3Mcwi 5131945 15 43509775 43756283 1 - by flanking markers 15 51307920 51550758 1 - by flanking markers 15 47488333 47800662 1 - by flanking markers 15 38363459 38677406 1 - by flanking markers RRID:RGD_5131950 5131951 SS-Prokr1em2Mcwi This strain was produced by injecting ZFNs targeting the sequence CGCCATGACCCTGTGCtatgcCAGGGTGTCCCGAGA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 126-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Prokr1em2Mcwi 5131947 4 121750651 121758116 1 - by flanking markers 4 183939201 183949822 1 - by flanking markers 4 119375790 119386551 1 - by flanking markers 4 120022301 120033379 1 - by flanking markers RRID:RGD_5131951 5131952 SS-Mas1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CCTGGGGACTTCACACCCACccattcCCATAGTGCACTGGGT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Mas1em1Mcwi 5131946 1 42154786 42185750 1 - by flanking markers 1 51644462 51675365 1 - by flanking markers 1 48076761 48108218 1 - by flanking markers 1 47879956 47911500 1 - by flanking markers RRID:RGD_5131952 5131953 SS-Prokr1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CGCCATGACCCTGTGCtatgcCAGGGTGTCCCGAGA into SS/JrHsdMcwi rat embryos. The resulting mutation is an 11-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Prokr1em1Mcwi 5131948 4 121750651 121758116 1 - by flanking markers 4 183939201 183949822 1 - by flanking markers 4 119375790 119386551 1 - by flanking markers 4 120022301 120033379 1 - by flanking markers RRID:RGD_5131953 5131954 SS-Mstnem2Mcwi This strain was produced by injecting ZFNs targeting the sequence CTTATTCCTTTGCAGCTGActttctAATGCAAGCGGATGGA into SS/JrHsdMcwi rat embryos. The resulting mutation is an 18-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Mstnem2Mcwi 5131949 9 45426831 45431658 1 - by flanking markers 9 52977371 52982198 1 - by flanking markers 9 53310977 53315804 1 - by flanking markers 9 48453982 48458809 1 - by flanking markers RRID:RGD_5131954 5131963 SS-Nox4em1Mcwi This strain was produced by injecting ZFNs targeting the sequence ggttacagcttctacctatgcaataaggtaagggtc into SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Nox4em1Mcwi 5131428 1 143415816 143603554 1 - by flanking markers 1 157106652 157285107 1 - by flanking markers 1 150796359 150976186 1 - by flanking markers 1 140900886 141078844 1 - by flanking markers RRID:RGD_5131963 5131964 SS-Mstnem3Mcwi This strain was produced by injecting ZFNs targeting the sequence CTTATTCCTTTGCAGCTGActttctAATGCAAGCGGATGGA into SS/JrHsdMcwi rat embryos. The resulting mutation is an 8-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Mstnem3Mcwi 5131962 9 45426831 45431658 1 - by flanking markers 9 52977371 52982198 1 - by flanking markers 9 53310977 53315804 1 - by flanking markers 9 48453982 48458809 1 - by flanking markers RRID:RGD_5131964 5131965 SS-Mthfrem1Mcwi This strain was produced by injecting ZFNs targeting the sequence CCCCAGCCCCCGATCtgaggGCAGCAGCAGTGGCA into SS/JrHsdMcwi rat embryos. The resulting mutation is an 28-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Mthfrem1Mcwi 5131961 5 165112850 165126885 1 - by flanking markers 5 168502556 168522350 1 - by flanking markers 5 164844642 164864360 1 - by flanking markers 5 158465248 158484999 1 - by flanking markers RRID:RGD_5131965 5131966 SS-Plod1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CATCGCTGCCGAATCttccagAACCTGGATGGAGCCTTG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Cryorecovery (as of 2017-01-26) Plod1em1Mcwi 5131960 5 164987252 165012581 1 - by flanking markers 5 168379092 168405534 1 - by flanking markers 5 164720629 164747071 1 - by flanking markers 5 158340674 158367581 1 - by flanking markers RRID:RGD_5131966 5131974 SS-Rasgrp3em1Mcwi This strain was produced by injecting ZFNs targeting the sequence TTCCCCCACAACACCTAATaagcctGTGGTACCCCTGGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a net insertion of 5-bp frameshift deletion in exon 12. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Rasgrp3em1Mcwi 5131968 6 19808453 19871923 1 - by flanking markers 6 30966364 31065175 1 - by flanking markers 6 21072634 21171619 1 - by flanking markers 6 19895366 19993945 1 - by flanking markers RRID:RGD_5131974 5131975 SS-Ptpn11em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTCTCCGTCCGCACTggtgaTGACAAAGGGGAGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 17-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ptpn11em1Mcwi 5131970 12 36501886 36558055 1 - by flanking markers 12 42762630 42822760 1 - by flanking markers 12 40895515 40955999 1 - by flanking markers 12 35365436 35424925 1 - by flanking markers RRID:RGD_5131975 5131976 SS-Ptpn11em4Mcwi This strain was produced by injecting ZFNs targeting the sequence CTCTCCGTCCGCACTggtgaTGACAAAGGGGAGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is an 84-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Ptpn11em4Mcwi 5131969 12 36501886 36558055 1 - by flanking markers 12 42762630 42822760 1 - by flanking markers 12 40895515 40955999 1 - by flanking markers 12 35365436 35424925 1 - by flanking markers RRID:RGD_5131976 5131987 SS-Tgfb1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGCTCCCACTCCCGTGGcttctAGTGCTGACGCCCGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 12-bp frameshift deletion in exon 3. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Tgfb1em1Mcwi 5131986 1 80894705 80911020 1 - by flanking markers 1 83742151 83758472 1 - by flanking markers 1 82480875 82497196 1 - by flanking markers 1 81196532 81212848 1 - by flanking markers RRID:RGD_5131987 5131988 SS-Wdr72em2Mcwi This strain was produced by injecting ZFNs targeting the sequence CCCTTCCTTACAGGCATActgccaTCTGCGTAAGTGCATGCC into SS/JrHsdMcwi rat embryos. The resulting mutation is a net 5-bp frameshift deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Wdr72em2Mcwi 5131978 8 78891358 79050751 1 - by flanking markers 8 80586841 80744090 1 - by flanking markers 8 80965734 81125710 1 - by flanking markers 8 74838338 75020938 1 - by flanking markers RRID:RGD_5131988 5131989 SS-Tgfb1em3Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGCTCCCACTCCCGTGGcttctAGTGCTGACGCCCGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 22-bp frameshift deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Tgfb1em3Mcwi 5131980 1 80894705 80911020 1 - by flanking markers 1 83742151 83758472 1 - by flanking markers 1 82480875 82497196 1 - by flanking markers 1 81196532 81212848 1 - by flanking markers RRID:RGD_5131989 5131990 SS-Slc30a8em2Mcwi This strain was produced by injecting ZFNs targeting the sequence TATCACTGCCACAACagcttcAAGGCCACAGGGAACAGGTC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 17-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Slc30a8em2Mcwi 5131981 7 88583770 88617145 1 - by flanking markers 7 92476024 92512365 1 - by flanking markers 7 91832988 91869329 1 - by flanking markers 7 83591993 83627786 1 - by flanking markers RRID:RGD_5131990 5131991 SS-Slc30a8em1Mcwi This strain was produced by injecting ZFNs targeting the sequence TATCACTGCCACAACagcttcAAGGCCACAGGGAACAGGTC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 17-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Slc30a8em1Mcwi 5131979 7 88583770 88617145 1 - by flanking markers 7 92476024 92512365 1 - by flanking markers 7 91832988 91869329 1 - by flanking markers 7 83591993 83627786 1 - by flanking markers RRID:RGD_5131991 5134683 WF.WKY-(D7Rat171-D7Rat128)/1Uwm Chromosome 7 segment from WKY that had the Mcs6 QTL was introgressed into a WF genetic background University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 7 22382724 121524220 1 - by flanking markers 7 26490428 124236725 1 - by flanking markers 7 26359973 124246733 1 - by flanking markers 7 20238970 114528048 1 - by flanking markers RRID:RGD_5134683 5134685 WF.WKY-(D7Rat171-D7Rat128)/2Uwm Chromosome 7 segment from WKY that had the Mcs6 QTL was introgressed into a WF genetic background University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 7 22382724 121524220 1 - by flanking markers 7 26490428 124236725 1 - by flanking markers 7 26359973 124246733 1 - by flanking markers 7 20238970 114528048 1 - by flanking markers RRID:RGD_5134685 5134687 WF.WKY-(D7Rat51-D7Rat128)/Uwm Chromosome 7 segment from WKY that had the Mcs6 QTL was introgressed into a WF genetic background University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 7 50833677 121524220 1 - by flanking markers 7 54558231 124236725 1 - by flanking markers 7 54534996 124246733 1 - by flanking markers 7 47251783 114528048 1 - by flanking markers RRID:RGD_5134687 5134689 WF.WKY-(D7Uwm25-D7Rat128)/Uwm Chromosome 7 segment from WKY that had the Mcs6 QTL was introgressed into a WF genetic background University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 7 121523977 121524220 1 - by flanking markers 7 89318050 124236725 1 - by flanking markers 7 89283487 124246733 1 - by flanking markers 7 81134174 114528048 1 - by flanking markers RRID:RGD_5134689 5134692 WF.WKY-(D7Rat171-D7Rat45)/Uwm Chromosome 7 segment from WKY that had the Mcs6 QTL was introgressed into a WF genetic background University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 7 22382724 68057251 1 - by flanking markers 7 26490428 71522360 1 - by flanking markers 7 26359973 71352127 1 - by flanking markers 7 20238970 63902784 1 - by flanking markers RRID:RGD_5134692 5134951 WF.COP-(D7Rat39-D7Uwm12)/1Uwm Chromosome 7 segment from WKY that had the Mcs2 QTL was introgressed into a WF genetic background University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 7 4936703 86007499 1 - by flanking markers 7 6276388 89299904 1 - by flanking markers 7 89265543 89265715 1 - by flanking markers 7 81116229 81116402 1 - by flanking markers RRID:RGD_5134951 5134953 WF.COP-(D7Rat39-D7Uwm12)/2Uwm Chromosome 7 segment from WKY that had the Mcs2 QTL was introgressed into a WF genetic background University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 7 4936703 86007499 1 - by flanking markers 7 6276388 89299904 1 - by flanking markers 7 89265543 89265715 1 - by flanking markers 7 81116229 81116402 1 - by flanking markers RRID:RGD_5134953 5135031 BN.MES-Cyba/Sna mutant Cyba gene from the MES/Slc strain is introduced into the background of BN/SsNSlc by standard procedures with seven backcrosses to BN/SsNSlc Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University, Matsumoto, Japan congenic Unknown RRID:RGD_5135031 5135472 ACI.BN-(D5Uwm70-D5Rat32)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 5 transferred to the ACI/SegHsd strain background Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 139659415 139659574 1 - by flanking markers 5 141933225 141933383 1 - by flanking markers 5 138123799 138123957 1 - by flanking markers 5 132686313 132686472 1 - by flanking markers RRID:RGD_5135472 5135473 ACI.BN-(D5Uwm70-D5Got42)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 5 transferred to the ACI/SegHsd strain background Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 130756424 130756605 1 - by flanking markers 5 132878119 132878299 1 - by flanking markers 5 129038716 129038896 1 - by flanking markers 5 124160767 124160948 1 - by flanking markers RRID:RGD_5135473 5135475 ACI.BN-(D5Rat60-D5Rat115)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 5 transferred to the ACI/SegHsd strain background Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 106262697 118138413 1 - by flanking markers 5 109291409 120337480 1 - by flanking markers 5 105304453 116395137 1 - by flanking markers 5 101467719 112419733 1 - by flanking markers RRID:RGD_5135475 5135477 ACI.BN-(D5Uwm70-D5Mgh15)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 5 transferred to the ACI/SegHsd strain background Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 167844579 167844737 1 - by flanking markers 5 171364494 171364652 1 - by flanking markers 5 167739539 167739697 1 - by flanking markers 5 161165494 161165651 1 - by flanking markers RRID:RGD_5135477 5135479 ACI.BN-(D5Rat113-D5Rat36)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 5 transferred to the ACI/SegHsd strain background Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 76707366 145187034 1 - by flanking markers 5 79957402 147610238 1 - by flanking markers 5 75809470 143846372 1 - by flanking markers 5 73483796 138113774 1 - by flanking markers RRID:RGD_5135479 5135481 ACI.BN-(D5Mgh17-D5Rat98)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 5 transferred to the ACI/SegHsd strain background Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 14730738 100017265 1 - by flanking markers 5 19190627 103451257 1 - by flanking markers 5 14408903 99421638 1 - by flanking markers 5 14529225 95774399 1 - by flanking markers RRID:RGD_5135481 5143940 ACI.FHH-(D1Rat74-D1Rat90)/Eur Congenic substrain that originated from ACI.FHH-(D1Rat298-D1Rat90)/Eur Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Unknown 1 227005311 267111153 1 - by flanking markers 1 248763714 289137268 1 - by flanking markers 1 241482188 281795785 1 - by flanking markers 1 221264111 259647894 1 - by flanking markers RRID:RGD_5143940 5143941 ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/EurMcwi Triple congenic ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Eur from Erasmus Medical Center, Rotterdam, Netherlands now bred and housed at Medical College of Wisconsin Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown RRID:RGD_5143941 5143942 ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Eur Triple congenic strain which was generated using the speed congenic strategy by backcrossing ACI/Eur and FHH/Eur parental strains. Rf-1A QTL region of chr 1 and Rf4 QTL region of chr 14 are introgressed in this strain. Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Unknown RRID:RGD_5143942 5143943 ACI.FHH-(D14Mit11-D14Rat82)/Eur Congenic strain generated by using the speed congenic strategy by backcrossing ACI/Eur and FHH/Eur parental strains. Rf4 QTL region of chr 14 is introgressed in this strain. Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Cryopreserved Sperm 14 4995006 30258439 1 - by flanking markers 14 4874267 30225437 1 - by flanking markers 14 4878162 30412508 1 - by flanking markers 14 3857038 28203397 1 - by flanking markers RRID:RGD_5143943 5143984 SS-Plekha7em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CCTCTGCCCAGCTACgtcatcTCCCCGGTGGCCCCCGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 16-bp frameshift deletion in exon 6. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Plekha7em1Mcwi 5143978 1 174249022 174316226 1 - by flanking markers 1 192397589 192463974 1 - by flanking markers 1 185427600 185493985 1 - by flanking markers 1 170364524 170547843 1 - by flanking markers RRID:RGD_5143984 5143985 SS-Mstnem1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTTATTCCTTTGCAGCTGActttctAATGCAAGCGGATGGA into SS/JrHsdMcwi rat embryos. The resulting mutation deletes part of exon 2 and its splice acceptor. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Mstnem1Mcwi 5143964 9 45426831 45431658 1 - by flanking markers 9 52977371 52982198 1 - by flanking markers 9 53310977 53315804 1 - by flanking markers 9 48453982 48458809 1 - by flanking markers RRID:RGD_5143985 5143986 SS-Ulk3em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CGCTCTACATGGCTCCTGAgatggtGTGTCGGCGGCAGTA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 5. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ulk3em1Mcwi 5143968 8 61343722 61348824 1 - by flanking markers 8 62146130 62152150 1 - by flanking markers 8 62368548 62375229 1 - by flanking markers 8 57992396 58000220 1 - by flanking markers RRID:RGD_5143986 5143987 SS-Gpr183em3Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGCCACTGCTCCtcaaaCCCATGTCTAAGCAGGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is an 8-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Gpr183em3Mcwi 5143961 15 107056367 107067887 1 - by flanking markers 15 111751148 111763869 1 - by flanking markers 15 108364701 108376221 1 - by flanking markers 15 99037764 99050550 1 - by flanking markers RRID:RGD_5143987 5143988 SS-Gpr183em2Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGCCACTGCTCCtcaaaCCCATGTCTAAGCAGGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 4-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Gpr183em2Mcwi 5143955 15 107056367 107067887 1 - by flanking markers 15 111751148 111763869 1 - by flanking markers 15 108364701 108376221 1 - by flanking markers 15 99037764 99050550 1 - by flanking markers RRID:RGD_5143988 5143989 SS-Agtrapem4Mcwi This strain was produced by injecting ZFNs targeting the sequence ATCCTGGCCCTGGGTgtgtggGCTGTGGCCCAGCGG into SS/JrHsdMcwi rat embryos. The resulting mutation is an 84-bp mutation deleting part of exon 3 and the splice acceptor. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Agtrapem4Mcwi 5143963 5 165154252 165164570 1 - by flanking markers 5 168546202 168556520 1 - by flanking markers 5 164888069 164898387 1 - by flanking markers 5 158507427 158519036 1 - by flanking markers RRID:RGD_5143989 5143990 SS-Ulk3em4Mcwi This strain was produced by injecting ZFNs targeting the sequence CGCTCTACATGGCTCCTGAgatggtGTGTCGGCGGCAGTA into SS/JrHsdMcwi rat embryos. The resulting mutation is an 88-bp frameshift deletion in exon 5. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ulk3em4Mcwi 5143971 8 61343722 61348824 1 - by flanking markers 8 62146130 62152150 1 - by flanking markers 8 62368548 62375229 1 - by flanking markers 8 57992396 58000220 1 - by flanking markers RRID:RGD_5143990 5143991 SS-Gpr183em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGCCACTGCTCCtcaaaCCCATGTCTAAGCAGGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Gpr183em1Mcwi 5143957 15 107056367 107067887 1 - by flanking markers 15 111751148 111763869 1 - by flanking markers 15 108364701 108376221 1 - by flanking markers 15 99037764 99050550 1 - by flanking markers RRID:RGD_5143991 5143992 SS-Rasgrp3em3Mcwi This strain was produced by injecting ZFNs targeting the sequence TTCCCCCACAACACCTAATaagcctGTGGTACCCCTGGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 20-bp frameshift deletion in exon 12. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Rasgrp3em3Mcwi 5143946 6 19808453 19871923 1 - by flanking markers 6 30966364 31065175 1 - by flanking markers 6 21072634 21171619 1 - by flanking markers 6 19895366 19993945 1 - by flanking markers RRID:RGD_5143992 5143993 SS-Plcd3em4Mcwi This strain was produced by injecting ZFNs targeting the sequence GCCCGCGTCATCCGAtagcagCACCAAAAGGCCCGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 161-bp deletion in exon 1 including the splice donor PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Plcd3em4Mcwi 5143954 10 92234651 92275433 1 - by flanking markers 10 90937117 90958001 1 - by flanking markers 10 91164778 91186067 1 - by flanking markers 10 88026707 88048080 1 - by flanking markers RRID:RGD_5143993 5143994 SS-Plcd3em7Mcwi This strain was produced by injecting ZFNs targeting the sequence GCCCGCGTCATCCGAtagcagCACCAAAAGGCCCGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 142-bp deletion, overlapping the start codon PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Plcd3em7Mcwi 5143976 10 92234651 92275433 1 - by flanking markers 10 90937117 90958001 1 - by flanking markers 10 91164778 91186067 1 - by flanking markers 10 88026707 88048080 1 - by flanking markers RRID:RGD_5143994 5143995 SS-Plekha7em4Mcwi This strain was produced by injecting ZFNs targeting the sequence CCTCTGCCCAGCTACgtcatcTCCCCGGTGGCCCCCGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 19-bp frameshift deletion in exon 8. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2017-01-26) Plekha7em4Mcwi 5143979 1 174249022 174316226 1 - by flanking markers 1 192397589 192463974 1 - by flanking markers 1 185427600 185493985 1 - by flanking markers 1 170364524 170547843 1 - by flanking markers RRID:RGD_5143995 5143996 SS-Agtrapem8Mcwi This strain was produced by injecting ZFNs targeting the sequence ATCCTGGCCCTGGGTgtgtggGCTGTGGCCCAGCGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 100-bp mutation deleting part of exon 3 and the splice acceptor. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Agtrapem8Mcwi 5143970 5 165154252 165164570 1 - by flanking markers 5 168546202 168556520 1 - by flanking markers 5 164888069 164898387 1 - by flanking markers 5 158507427 158519036 1 - by flanking markers RRID:RGD_5143996 5144101 SS-Kcnq1em14Mcwi This strain was produced by injecting ZFNs targeting the sequence GTCTGCAGGCTGCCGCagcaagTACGTGGGCATCTGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 17-bp frameshift deletion in exon 3. PhysGen Knockouts mutant Cryorecovery (as of 2017-01-26) Kcnq1em14Mcwi 5144083 1 203383401 203803687 1 - by flanking markers 1 223154713 223490458 1 - by flanking markers 1 216293087 216630339 1 - by flanking markers 1 198291711 198624683 1 - by flanking markers RRID:RGD_5144101 5144102 ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/EurMcwi-Asipem1Mcwi This strain was produced by injecting ZFNs targeting the sequence agccacctggtatttgaggagacgcttggagatgac into ACI.FHH(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90) embryos. The result is a 5-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Asipem1Mcwi 5144099 3 145445175 145536831 1 - by flanking markers 3 156860395 156949277 1 - by flanking markers 3 150492010 150579870 1 - by flanking markers 3 143473584 143561170 1 - by flanking markers RRID:RGD_5144102 5144103 SS-Ldlrem1Mcwi This strain was produced by injecting ZFNs targeting the sequence TGCATCCCCAGCCTGTGGgcctgcGACGGGGACCGGGAC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ldlrem1Mcwi 5144090 8 20824040 20846920 1 - by flanking markers 8 22804325 22827199 1 - by flanking markers 8 22750425 22773305 1 - by flanking markers 8 20270020 20292981 1 - by flanking markers RRID:RGD_5144103 5144104 SS-Ncf2em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTCTACTACAGCATGgagaagTAAGTGGTGTCGGAGTGT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2017-01-26) Ncf2em1Mcwi 5144089 13 67806516 67834105 1 - by flanking markers 13 75197561 75229600 1 - by flanking markers 13 70226441 70259019 1 - by flanking markers 13 64955502 64986289 1 - by flanking markers RRID:RGD_5144104 5144105 SS-Hexim2em4Mcwi This strain was produced by injecting ZFNs targeting the sequence CAGCCCACTCGGCCCggcctcTCCCCGCGCCCGGAC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Hexim2em4Mcwi 5144095 10 92306494 92312256 1 - by flanking markers 10 90988728 90994491 1 - by flanking markers 10 91212296 91222841 1 - by flanking markers 10 88077870 88084776 1 - by flanking markers RRID:RGD_5144105 5144106 SS-Kcnq1em9Mcwi This strain was produced by injecting ZFNs targeting the sequence GTCTGCAGGCTGCCGCagcaagTACGTGGGCATCTGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp frameshift deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Kcnq1em9Mcwi 5144076 1 203383401 203803687 1 - by flanking markers 1 223154713 223490458 1 - by flanking markers 1 216293087 216630339 1 - by flanking markers 1 198291711 198624683 1 - by flanking markers RRID:RGD_5144106 5144107 SS-Itga9em1Mcwi This strain was produced by injecting ZFNs targeting the sequence GTCGGAGCCTTCCTGTCCgacagcGTGGTTCTCCTCAGGT into SS/JrHsdMcwi rat embryos. The resulting mutation is an 87-bp deletion containing part of exon 13 and its splice acceptor. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Itga9em1Mcwi 5144077 8 123526904 123838241 1 - by flanking markers 8 126493359 126795566 1 - by flanking markers 8 127271029 127576709 1 - by flanking markers 8 118307424 118615527 1 - by flanking markers RRID:RGD_5144107 5144108 SS-Ldlrem4Mcwi This strain was produced by injecting ZFNs targeting the sequence TGCATCCCCAGCCTGTGGgcctgcGACGGGGACCGGGAC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ldlrem4Mcwi 5144075 8 20824040 20846920 1 - by flanking markers 8 22804325 22827199 1 - by flanking markers 8 22750425 22773305 1 - by flanking markers 8 20270020 20292981 1 - by flanking markers RRID:RGD_5144108 5144110 ACI.BN-(D5Mgh17-D5Mgh15)/Shul This congenic strain is developed by further genotyping ACI.BN-(D5Mgh17-D5Rat205)/Shul. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 14730738 167844737 1 - by flanking markers 5 19190627 171364652 1 - by flanking markers 5 14408903 167739697 1 - by flanking markers 5 14529225 161165651 1 - by flanking markers RRID:RGD_5144110 5147594 FHH.PCK-(D9Rat35-D9Rat70)/Mcwi A FHH/EurMcwi male was crossed with a PCK/CrljCrl-Pkhd1pck/Crl female, and the male progeny were backcrossed to FHH/EurMcwi females for five generations by marker assisted breeding. In each generation, males were genotyped by fluorescent genotyping for three markers within the Pkhd1 gene, and 98 markers evenly spaced throughout the genome. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown Pkhd1pck 11535943 9 12916127 21667256 1 - by flanking markers 9 18672124 27914444 1 - by flanking markers 9 19794101 29075268 1 - by flanking markers 9 17220476 25268236 1 - by flanking markers RRID:RGD_5147594 5490515 FHH.BN(D1Rat265-D1Rat76)/Mcwi desired segments from BN were introgressed in FHH background Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Extinct 1 90448902 230411453 1 - by flanking markers 1 95453405 252243871 1 - by flanking markers 1 94364073 244992610 1 - by flanking markers 1 90664883 224569684 1 - by flanking markers RRID:RGD_5490515 5490516 FHH.BN(D14Rat80-D14Hmgc4)/Mcwi desired segments from BN were introgressed in FHH background Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Live Animals; Cryopreserved Sperm 14 13778105 21435476 1 - by flanking markers 14 13914610 21463742 1 - by flanking markers 14 13971208 21555302 1 - by flanking markers 14 12326866 19848266 1 - by flanking markers RRID:RGD_5490516 5490517 FHH.BN(D14Rat78-D14Hmgc4)/Mcwi desired segments from BN were introgressed in FHH background Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Live Animals; Cryopreserved Sperm 14 17564855 21435476 1 - by flanking markers 14 17417347 21463742 1 - by flanking markers 14 17499969 21555302 1 - by flanking markers 14 15995099 19848266 1 - by flanking markers RRID:RGD_5490517 5508304 WUN-Abcc2TR-/HsdRrrc Spontaneous 1-bp deletion mutation occurred on a Wistar Unilever maintained at the Amsterdam Academic Medical Center (AMC). This mutation at amino acid 393 resulting a frameshift and premature stop at position 401. Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-08-02) Abcc2|Abcc2TR- 2366|12792941 1 270999832 271057750 1 - by flanking markers 1 263554426 263612556 1 - by flanking markers 1 242664657 242723239 1 - by flanking markers RRID:RRRC_00442 5508305 F344-Dpp4DPPIV-/DchcHsdRrrc The DPP4 mutant rat was a spontaneous mutation in Fischer 344 rats, which caused a deficiency in DPPIV, was identified by Dr. Douglas C. Hixson at Rhode Island Hospital. Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-03-16) Dpp4DPPIV 12792942 3 44279255 44360283 1 - by flanking markers 3 54957146 55038628 1 - by flanking markers 3 48291055 48372672 1 - by flanking markers 3 46962243 47043870 1 - by flanking markers RRID:RRRC_00443 5508356 SS-Gucy1a3em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CCCTGCTTCTCCCCGGTAtcattAAAGCGGCTGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp frameshift deletion in exon 5. PhysGen Knockouts mutant Extinct Gucy1a3em1Mcwi 5508351 2 173756824 173818316 1 - by flanking markers 2 200453480 200515219 1 - by flanking markers 2 181045694 181103321 1 - by flanking markers 2 167418615 167482293 1 - by flanking markers RRID:RGD_5508356 5508357 SS-Tfdp2em2Mcwi This strain was produced by injecting ZFNs targeting the sequence GTCTGAGTTTACcaatgcGAGTAACCATCTGGCAGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp frameshift deletion in exon 6. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Tfdp2em2Mcwi 5508332 8 101256112 101392512 1 - by flanking markers 8 103489105 103629520 1 - by flanking markers 8 104040795 104181228 1 - by flanking markers 8 96760459 96901466 1 - by flanking markers RRID:RGD_5508357 5508358 SS-Wdr72em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CCCTTCCTTACAGGCATActgccaTCTGCGTAAGTGCATGCC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp deletion in exon 3 and intron 3 PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Wdr72em1Mcwi 5508327 8 78891358 79050751 1 - by flanking markers 8 80586841 80744090 1 - by flanking markers 8 80965734 81125710 1 - by flanking markers 8 74838338 75020938 1 - by flanking markers RRID:RGD_5508358 5508359 SS-Pruneem3Mcwi This strain was produced by injecting ZFNs targeting the sequence ACCTCCGGCTTCACCATGgaggacTACTTGCAGGAC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 32-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Pruneem3Mcwi 5508348 2 190165356 190192807 1 - by flanking markers 2 215924545 215954221 1 - by flanking markers 2 196427714 196457105 1 - by flanking markers 2 182830575 182859972 1 - by flanking markers RRID:RGD_5508359 5508360 SS-Dguokem4Mcwi This strain was produced by injecting ZFNs targeting the sequence GTCGGTTCCTTCTGCgtagacTCCGAGCGTCTTTCCG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 9-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Dguokem4Mcwi 5508323 4 117697251 117725383 1 - by flanking markers 4 179770727 179798683 1 - by flanking markers 4 115180433 115208061 1 - by flanking markers 4 115987101 116014733 1 - by flanking markers RRID:RGD_5508360 5508361 SS-Bcas3em4Mcwi This strain was produced by injecting ZFNs targeting the sequence TGGATCTGTACTCACttcgtACGGGGGAGATGGTCAAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp frameshift deletion in exon 9. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Bcas3em4Mcwi 5508329 10 73617547 74078190 1 - by flanking markers 10 72660671 73177317 1 - by flanking markers 10 72756548 73271851 1 - by flanking markers 10 70213710 70673080 1 - by flanking markers RRID:RGD_5508361 5508362 SS-Ncf2em4Mcwi This strain was produced by injecting ZFNs targeting the sequence CTCTACTACAGCATGgagaagTAAGTGGTGTCGGAGTGT into SS/JrHsdMcwi rat embryos. The resulting mutation is a net 139-bp deletion of part of intron 1 and exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ncf2em4Mcwi 5508342 13 67806516 67834105 1 - by flanking markers 13 75197561 75229600 1 - by flanking markers 13 70226441 70259019 1 - by flanking markers 13 64955502 64986289 1 - by flanking markers RRID:RGD_5508362 5508363 SS-Sorcs2em4Mcwi This strain was produced by injecting ZFNs targeting the sequence CACATCAGCTTCCGCTCTgactggGAGCTGGTCAAGGTGGAC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp frameshift deletion in exon 15. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Sorcs2em4Mcwi 5508326 14 79968072 80344330 1 - by flanking markers 14 79176694 79547823 1 - by flanking markers 14 79538911 79912333 1 - by flanking markers 14 74371089 74735943 1 - by flanking markers RRID:RGD_5508363 5508364 SS-Pruneem1Mcwi This strain was produced by injecting ZFNs targeting the sequence ACCTCCGGCTTCACCATGgaggacTACTTGCAGGAC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 198-bp deletion in the 5 prime URT and exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Pruneem1Mcwi 5508341 2 190165356 190192807 1 - by flanking markers 2 215924545 215954221 1 - by flanking markers 2 196427714 196457105 1 - by flanking markers 2 182830575 182859972 1 - by flanking markers RRID:RGD_5508364 5508365 SS-Agtr1aem5Mcwi This strain was produced by injecting ZFNs targeting the sequence CTTTGCCCCTGTGGGCAGtctatACCGCTATGGAGTACCGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 19-bp frameshift deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Agtr1aem5Mcwi 5508318 17 40629318 40684982 1 - by flanking markers 17 37217810 37270540 1 - by flanking markers 17 35907102 35958136 1 - by flanking markers 17 34173446 34226892 1 - by flanking markers RRID:RGD_5508365 5508366 SS-Tfdp2em5Mcwi This strain was produced by injecting ZFNs targeting the sequence GTCTGAGTTTACcaatgcGAGTAACCATCTGGCAGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 16-bp frameshift deletion in exon 6. PhysGen Knockouts mutant Extinct Tfdp2em5Mcwi 5508334 8 101256112 101392512 1 - by flanking markers 8 103489105 103629520 1 - by flanking markers 8 104040795 104181228 1 - by flanking markers 8 96760459 96901466 1 - by flanking markers RRID:RGD_5508366 5508367 SS-Ulk4em3Mcwi This strain was produced by injecting ZFNs targeting the sequence CTACCTTGTAGCTACccaggtGAGGCTGTCTGATGAA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp deletion in exon 15 and intron 15 PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ulk4em3Mcwi 5508340 8 125992455 126284263 1 - by flanking markers 8 128829597 129125286 1 - by flanking markers 8 129631003 129919080 1 - by flanking markers 8 120670879 120966026 1 - by flanking markers RRID:RGD_5508367 5508368 SS-Trafd1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGTGGTGCCCGGACagagcTGTGTGGCAGCTGTG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp frameshift deletion in exon 5. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Trafd1em1Mcwi 5508352 12 36301824 36315741 1 - by flanking markers 12 42562635 42576553 1 - by flanking markers 12 40695520 40709438 1 - by flanking markers 12 35165606 35179525 1 - by flanking markers RRID:RGD_5508368 5508369 SS-Myadml2em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGATGGGCAGCACCATGgaccccCCGGGGGGTGCA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Myadml2em1Mcwi 5508317 10 110039330 110040967 1 - by flanking markers 10 109418559 109420196 1 - by flanking markers 10 109822170 109827328 1 - by flanking markers 10 105922557 105927867 1 - by flanking markers RRID:RGD_5508369 5508370 SS-Nppbem2Mcwi This strain was produced by injecting ZFNs targeting the sequence TTCCCAATTCGTCACAgaagctGCTGGAGCTGATAAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 100-bp deletion of part of intron 1 and exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Nppbem2Mcwi 5508324 5 165062348 165063650 1 - by flanking markers 5 168454278 168455640 1 - by flanking markers 5 164796176 164797538 1 - by flanking markers 5 158416813 158418175 1 - by flanking markers RRID:RGD_5508370 5508371 SS-Mylipem3Mcwi This strain was produced by injecting ZFNs targeting the sequence GCCCCAGCCATGCTGTGCtatgtGACGAGGCCGGACGCGGTG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 51-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Extinct Mylipem3Mcwi 5508336 17 25308147 25329887 1 - by flanking markers 17 21703590 21725205 1 - by flanking markers 17 19682040 19703681 1 - by flanking markers 17 19286649 19308295 1 - by flanking markers RRID:RGD_5508371 5508380 SS-TgTn(T2ONC)2Mcwi These rats were made by pronuclear injection of a linear plasmid fragment containing a Sleeping Beauty oncogenic transposon harboring the CAG (chicken beta-actin/rabbit beta-globin hybrid promoter), the mouse Foxf2 exon 1 splice donor, and two Adenovirus 2 splice acceptors on opposite DNA strands. PhysGen Knockouts transgenic Cryopreserved Sperm RRID:RGD_5508380 5508381 SS-TgTn(T2ONC)1Mcwi These rats were made by pronuclear injection of a linear plasmid fragment containing a Sleeping Beauty oncogenic transposon harboring the CAG (chicken beta-actin/rabbit beta-globin hybrid promoter), the mouse Foxf2 exon 1 splice donor, and two Adenovirus 2 splice acceptors on opposite DNA strands. PhysGen Knockouts transgenic Cryopreserved Sperm RRID:RGD_5508381 5508392 HsdHlr:ZUC-Leprfa Derived from a colony obtained in 1992 from Hoffmann-la-Roche, Nutley, New Jersey. Envigo outbred Unknown Leprfa 13432153 RRID:RGD_5508392 5508393 BN/RijHsd These were derived from a nucleus colony obtained directly from the TNO Institute, the Netherlands now available at Envigo. Envigo inbred Unknown RRID:RGD_5508393 5508394 FBNF1/Hsd Offspring of a cross between the F344/NHsd inbred female and a BN male rat. Harlan hybrid Unknown RRID:RGD_5508394 5508395 Hsd:RH-Foxn1rnu Athymic Nude Derived from animals obtained from the Rowett Research Institute, Aberdeen, Scotland. Envigo outbred Unknown RRID:RGD_5508395 5508396 HsdRccHan:WIST Derived at Biological Research Laboratories Limited (BRL), formerly RCC, now Harlan Laboratories Ltd., Fullinsdorf, Switzerland from original colony at Zentralinstitute fur Versuchstierzucht, Hannover in 1989. Transferred to Harlan Sprague-Dawley, Inc. in 1993 (nomenclature HsdHan:WIST). Harlan became Envigo in 2015. In 2004 Envigo acquired RCC Ltd. and new breeding stock was transferred in 2008 (nomenclature RccHan:WIST). Unlike competitive models, the RccHan:WIST rat has been maintained from the original nucleus of 156 breeding pairs in Hannover, Germany. ENVIGO outbred Unknown RRID:RGD_5508396 5508397 HotHsd:SD Sprague Dawley Originally developed by the Holtzman Company in Madison, Wisconsin, from Sprague Dawley stock in 1947; to Harlan through acquisition in 1986. Envigo outbred Unknown RRID:RGD_5508397 5508398 BluHsd:LE Long Evans (Blue Spruce) From the University of Rochester, Rochester, New York; to Blue Spruce Farms, Altamont, New York, in 1964; to Harlan through acquisition in 1988. Harlan became Envigo in 2015. Harlan/Envigo outbred Unknown RRID:RGD_5508398 5509086 ACI.BN-(D5Rat72-D5Rat36)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 5 transferred to the ACI/SegHsd strain background Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 120983238 145187034 1 - by flanking markers 5 123027973 147610238 1 - by flanking markers 5 119124918 143846372 1 - by flanking markers 5 114973303 138113774 1 - by flanking markers RRID:RGD_5509086 5509087 ACI.BN-(D5Rat113-D5Rat159)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 5 transferred to the ACI/SegHsd strain background Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 76707366 76707563 1 - by flanking markers 5 79957402 79957599 1 - by flanking markers 5 75809470 75809667 1 - by flanking markers 5 73483796 73483994 1 - by flanking markers RRID:RGD_5509087 5509988 SS-Nppbem4Mcwi This strain was produced by injecting ZFNs targeting the sequence TTCCCAATTCGTCACAgaagctGCTGGAGCTGATAAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 138-bp deletion of part of intron 1 and exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Nppbem4Mcwi 5509979 5 165062348 165063650 1 - by flanking markers 5 168454278 168455640 1 - by flanking markers 5 164796176 164797538 1 - by flanking markers 5 158416813 158418175 1 - by flanking markers RRID:RGD_5509988 5509989 SS-Msraem4Mcwi This strain was produced by injecting ZFNs targeting the sequence CTCATCTTCGAAGGTCatcagcGCGGAGGAAGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is a net 1-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Msraem4Mcwi 5509977 15 43509775 43756283 1 - by flanking markers 15 51307920 51550758 1 - by flanking markers 15 47488333 47800662 1 - by flanking markers 15 38363459 38677406 1 - by flanking markers RRID:RGD_5509989 5509990 SS-Cyp1a1em2Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGGTAACCAACCCTAGGatacagAGAAAGATCCAGGAGGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 188-bp deletion encompassing exon 4 PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Cyp1a1em2Mcwi 5509976 8 61462207 61468237 1 - by flanking markers 8 62249046 62255081 1 - by flanking markers 8 62472087 62478122 1 - by flanking markers 8 58096021 58102130 1 - by flanking markers RRID:RGD_5509990 5509991 SS-Mylipem2Mcwi This strain was produced by injecting ZFNs into SS/JrHsdMcwi rat embryos. The resulting mutation is a 49-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Mylipem2Mcwi 5508333 17 25308147 25329887 1 - by flanking markers 17 21703590 21725205 1 - by flanking markers 17 19682040 19703681 1 - by flanking markers 17 19286649 19308295 1 - by flanking markers RRID:RGD_5509991 5509992 SS-Ube2q2em3Mcwi This strain was produced by injecting ZFNs targeting the sequence TGCTAGATCAACcactaCCCACGGGTCAGGTA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ube2q2em3Mcwi 5509987 8 58688257 58749088 1 - by flanking markers 8 58292660 58349722 1 - by flanking markers 8 59709972 59754102 1 - by flanking markers 8 55518402 55578342 1 - by flanking markers RRID:RGD_5509992 5509993 SS-Tcf7l2em1Mcwi This strain was produced by injecting ZFNs targeting the sequence GGAAGCCTCCAGAGCagacaaGCCCTCAAGGATGCC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 169-bp deletion of exon5 and intron 5. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Tcf7l2em1Mcwi 5509981 1 262031823 262226710 1 - by flanking markers 1 283387566 284118928 1 - by flanking markers 1 276686911 276730517 1 - by flanking markers 1 254785956 254978967 1 - by flanking markers RRID:RGD_5509993 5509994 SS-Sh2b3em2Mcwi This strain was produced by injecting ZFNS targeting the sequence ctcccccatcccacttgaatgtggagcagcctgtg into SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp deletion in exon 7 in SS/JrHsdMcwi. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Sh2b3em2Mcwi 5509982 12 35954679 35958446 1 - by flanking markers 12 42132947 42136714 1 - by flanking markers 12 40261990 40265757 1 - by flanking markers 12 34749849 34753616 1 - by flanking markers RRID:RGD_5509994 5509995 SS-Adra2aem1Mcwi This strain was produced by injecting ZFNs targeting the sequence CAGGCATCCCAGGATATCctggtcACAATGGGATACCGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 47-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Adra2aem1Mcwi 5509986 1 282178475 282181275 1 - by flanking markers 1 274766283 274769083 1 - by flanking markers 1 253061480 253064280 1 - by flanking markers RRID:RGD_5509995 5509996 SS-Stk39em2Mcwi This strain was produced by injecting ZFNs targeting the sequence AACAGCCATTGAattagCAACGGGAGCAGCGC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 24-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Extinct Stk39em2Mcwi 5509978 3 50249626 50517085 1 - by flanking markers 3 60973443 61244306 1 - by flanking markers 3 54359449 54625702 1 - by flanking markers 3 52913583 53179060 1 - by flanking markers RRID:RGD_5509996 5509997 SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi This strain was produced by injecting ZFNs targeting the sequence ctctgaaccttcaactttcagatactgatgacaatgaa into SS.BN-(D13Rat20-D13Got22)/Mcwi rat embryos. The resulting mutation is an 11-bp frameshift deletion in exon 6. PhysGen Knockouts mutant Extinct Nckap5em4Mcwi 5509975 13 38444115 39275959 1 - by flanking markers 13 47369687 48273649 1 - by flanking markers 13 42265875 43049232 1 - by flanking markers 13 37369948 38283257 1 - by flanking markers RRID:RGD_5509997 5529230 ACI.FHH-(D1Hmgc16-D1Rat225)/Mcwi desired segments from FHH/EurMcwi were introgressed in ACI/Eur background Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Cryopreserved Sperm 1 261180160 261180301 1 - by flanking markers 1 275301183 283061559 1 - by flanking markers 1 267871151 271693968 1 - by flanking markers 1 246983819 246984013 1 - by flanking markers RRID:RGD_5529230 5529529 ACI.FHH-(D1Hmgc1-D1Hmgc19)/Mcwi desired segments from FHH/EurMcwi were introgressed in ACI/Eur background Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Cryopreserved Sperm 1 249745626 249745784 1 - by flanking markers 1 271889649 277901651 1 - by flanking markers 1 264446896 270462479 1 - by flanking markers 1 243559115 249583894 1 - by flanking markers RRID:RGD_5529529 5529731 ACI.FHH-(D1Hmgc20-D1Hmgc21)/Mcwi desired segments from FHH/EurMcwi were introgressed in ACI/Eur background Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Cryopreserved Sperm 1 274674350 276466399 1 - by flanking markers 1 267241552 269024803 1 - by flanking markers 1 246355367 248138424 1 - by flanking markers RRID:RGD_5529731 5683886 SS-Chr 12BN.SS-(D12Arb13-D12Mit2)/Mcwi These were generated by crossing SS/JrHsdMcwi with SS-Chr 12BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 12 7382721 20932776 1 - by flanking markers 12 10334114 24663199 1 - by flanking markers 12 8249608 22650918 1 - by flanking markers 12 6833190 19611091 1 - by flanking markers RRID:RGD_5683886 5683888 SS-Chr 12BN.SS-(D12Hmgc3-D12Rat79)/Mcwi These were generated by crossing SS/JrHsdMcwi with SS-Chr 12BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 12 36223785 36224090 1 - by flanking markers 12 17102817 42485122 1 - by flanking markers 12 15085585 40618007 1 - by flanking markers 12 13008296 35088624 1 - by flanking markers RRID:RGD_5683888 5683890 SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi These were generated by crossing SS/JrHsdMcwi with SS-Chr 12BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 12 17102817 24300160 1 - by flanking markers 12 15085585 22283507 1 - by flanking markers 12 13008296 19212979 1 - by flanking markers RRID:RGD_5683890 5685369 SS-Agtr1aem1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTTTGCCCCTGTGGGCAGtctatACCGCTATGGAGTACCGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 2-bp frameshift deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Agtr1aem1Mcwi 5508331 17 40629318 40684982 1 - by flanking markers 17 37217810 37270540 1 - by flanking markers 17 35907102 35958136 1 - by flanking markers 17 34173446 34226892 1 - by flanking markers RRID:RGD_5685369 5686300 SS-Adra2aem1Mcwi-/- SS-Adra2aem1Mcwi-/Adra2aem1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2019-07-26) Adra2aem1Mcwi 5509986 1 282178475 282181275 1 - by flanking markers 1 274766283 274769083 1 - by flanking markers 1 253061480 253064280 1 - by flanking markers RRID:RGD_5686300 5686302 SS-Adra2aem1Mcwi+/+ SS-Adra2aem1Mcwi+/Adra2aem1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686302 5686304 SS-Agtrapem4Mcwi-/- SS-Agtrapem4Mcwi-/Agtrapem4Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Embryo (as of 2018-09-05) RRID:RGD_5686304 5686306 SS-Agtrapem4Mcwi+/+ SS-Agtrapem4Mcwi+/Agtrapem4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686306 5686308 SS-Hexim2em4Mcwi-/- SS-Hexim2em4Mcwi-/Hexim2em4Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686308 5686311 SS-Hexim2em4Mcwi+/+ SS-Hexim2em4Mcwi+/Hexim2em4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686311 5686314 SS-Rasgrp3em1Mcwi-/- SS-Rasgrp3em1Mcwi-/Rasgrp3em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686314 5686316 SS-Rasgrp3em1Mcwi+/+ SS-Rasgrp3em1Mcwi+/Rasgrp3em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686316 5686318 SS-Sh2b3em1Mcwi-/- SS-Sh2b3em1Mcwi-/Sh2b3em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. The resulting mutation is an in-frame 6-bp deletion in exon 2 . PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Sh2b3em1Mcwi 4139858 12 35954679 35958446 1 - by flanking markers 12 42132947 42136714 1 - by flanking markers 12 40261990 40265757 1 - by flanking markers 12 34749849 34753616 1 - by flanking markers RRID:RGD_5686318 5686320 SS-Sh2b3em1Mcwi+/+ SS-Sh2b3em1Mcwi+/Sh2b3em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686320 5686322 SS-Sh2b3em1Mcwi-/+ SS-Sh2b3em1Mcwi-/Sh2b3em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Sh2b3em1Mcwi 4139858 12 35954679 35958446 1 - by flanking markers 12 42132947 42136714 1 - by flanking markers 12 40261990 40265757 1 - by flanking markers 12 34749849 34753616 1 - by flanking markers RRID:RGD_5686322 5686326 SS-Ulk3em4Mcwi-/- SS-Ulk3em4Mcwi-/Ulk3em4Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686326 5686328 SS-Ulk3em4Mcwi+/+ SS-Ulk3em4Mcwi+/Ulk3em4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686328 5686330 SS-Ulk3em4Mcwi-/+ SS-Ulk3em4Mcwi-/Ulk3em4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686330 5686332 SS-Wdr72em2Mcwi-/- SS-Wdr72em2Mcwi-/Wdr72em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686332 5686335 SS-Wdr72em2Mcwi+/+ SS-Wdr72em2Mcwi+/Wdr72em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686335 5686652 SS-Agtr1aem1Mcwi-/- SS-Agtr1aem1Mcwi-/Agtr1aem1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686652 5686654 SS-Agtr1aem1Mcwi+/+ SS-Agtr1aem1Mcwi+/Agtr1aem1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686654 5686657 SS-Agtr1aem5Mcwi-/- SS-Agtr1aem5Mcwi-/Agtr1aem5Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686657 5686659 SS-Agtrapem8Mcwi-/- SS-Agtrapem8Mcwi-/Agtrapem8Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686659 5686662 SS-Agtrapem8Mcwi+/+ SS-Agtrapem8Mcwi+/Agtrapem8Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686662 5686664 SS-Aldh2em2Mcwi-/- SS-Aldh2em2Mcwi-/Aldh2em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686664 5686666 SS-Aldh2em2Mcwi+/+ SS-Aldh2em2Mcwi+/Aldh2em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686666 5686668 SS-Cdh13em1Mcwi-/- SS-Cdh13em1Mcwi-/Cdh13em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryorecovery (as of 2018-09-05) RRID:RGD_5686668 5686670 SS-Cdh13em1Mcwi+/+ SS-Cdh13em1Mcwi+/Cdh13em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686670 5686672 SS-Cyp1a1em1Mcwi-/- SS-Cyp1a1em1Mcwi-/Cyp1a1em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2019-11-06) RRID:RGD_5686672 5686676 SS-Cyp1a1em1Mcwi+/+ SS-Cyp1a1em1Mcwi+/Cyp1a1em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686676 5686678 SS-Cyp1a1em2Mcwi-/- SS-Cyp1a1em2Mcwi-/Cyp1a1em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686678 5686680 SS-Cyp1a1em2Mcwi+/+ SS-Cyp1a1em2Mcwi+/Cyp1a1em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686680 5686684 SS-Cyp1a1em5Mcwi-/- SS-Cyp1a1em5Mcwi-/Cyp1a1em5Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct (as of 2018-09-05) RRID:RGD_5686684 5686687 SS-Cyp1a1em5Mcwi+/+ SS-Cyp1a1em5Mcwi+/Cyp1a1em5Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686687 5686689 SS-Prokr1em1Mcwi-/- SS-Prokr1em1Mcwi-/Prokr1em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct (as of 2018-09-05) RRID:RGD_5686689 5686692 SS-Prokr1em1Mcwi+/+ SS-Prokr1em1Mcwi+/Prokr1em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686692 5686695 SS-Prokr1em2Mcwi-/- SS-Prokr1em2Mcwi-/Prokr1em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct (as of 2018-09-05) RRID:RGD_5686695 5686697 SS-Prokr1em2Mcwi+/+ SS-Prokr1em2Mcwi+/Prokr1em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686697 5686700 SS-Kcnq1em14Mcwi-/- SS-Kcnq1em14Mcwi-/Kcnq1em14Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryorecovery (as of 2018-09-05) RRID:RGD_5686700 5686702 SS-Kcnq1em14Mcwi+/+ SS-Kcnq1em14Mcwi+/Kcnq1em14Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686702 5686704 SS-Msraem3Mcwi-/- SS-Msraem3Mcwi-/Msraem3Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686704 5686706 SS-Msraem3Mcwi+/+ SS-Msraem3Mcwi+/Msraem3Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686706 5686708 SS-Msraem4Mcwi-/- SS-Msraem4Mcwi-/Msraem4Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686708 5686710 SS-Msraem4Mcwi+/+ SS-Msraem4Mcwi+/Msraem4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686710 5686713 SS-Mstnem1Mcwi-/- SS-Mstnem1Mcwi-/Mstnem1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2019-07-26) Mstnem1Mcwi 5143964 9 45426831 45431658 1 - by flanking markers 9 52977371 52982198 1 - by flanking markers 9 53310977 53315804 1 - by flanking markers 9 48453982 48458809 1 - by flanking markers RRID:RGD_5686713 5686715 SS-Mstnem1Mcwi+/+ SS-Mstnem1Mcwi+/Mstnem1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686715 5686718 SS-Mstnem3Mcwi-/- SS-Mstnem3Mcwi-/Mstnem3Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2019-07-26) Mstnem3Mcwi 5131962 9 45426831 45431658 1 - by flanking markers 9 52977371 52982198 1 - by flanking markers 9 53310977 53315804 1 - by flanking markers 9 48453982 48458809 1 - by flanking markers RRID:RGD_5686718 5686721 SS-Mstnem3Mcwi+/+ SS-Mstnem3Mcwi+/Mstnem3Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686721 5686723 SS-Mstnem3Mcwi-/+ SS-Mstnem3Mcwi-/Mstnem3Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686723 5686725 SS-Nppaem4Mcwi-/- SS-Nppaem4Mcwi-/Nppaem4Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686725 5686728 SS-Nppaem4Mcwi+/+ SS-Nppaem4Mcwi+/Nppaem4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686728 5686730 SS-Nppbem2Mcwi-/- SS-Nppbem2Mcwi-/Nppbem2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown Nppbem2Mcwi 5508324 5 165062348 165063650 1 - by flanking markers 5 168454278 168455640 1 - by flanking markers 5 164796176 164797538 1 - by flanking markers 5 158416813 158418175 1 - by flanking markers RRID:RGD_5686730 5686732 SS-Nppbem2Mcwi+/+ SS-Nppbem2Mcwi+/Nppbem2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686732 5686734 SS-Nppbem4Mcwi-/- SS-Nppbem4Mcwi-/Nppbem4Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryorecovery (as of 2018-09-05) RRID:RGD_5686734 5686736 SS-Nppbem4Mcwi+/+ SS-Nppbem4Mcwi+/Nppbem4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686736 5686738 SS-Plcd3em4Mcwi-/- SS-Plcd3em4Mcwi-/Plcd3em4Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686738 5686740 SS-Plcd3em4Mcwi+/+ SS-Plcd3em4Mcwi+/Plcd3em4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686740 5686742 SS-Plcd3em7Mcwi-/- SS-Plcd3em7Mcwi-/Plcd3em7Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686742 5686744 SS-Plcd3em7Mcwi+/+ SS-Plcd3em7Mcwi+/Plcd3em7Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686744 5686747 SS-Plekha7em1Mcwi-/- SS-Plekha7em1Mcwi-/Plekha7em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686747 5686749 SS-Plekha7em1Mcwi+/+ SS-Plekha7em1Mcwi+/Plekha7em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686749 5686758 SS-Plekha7em4Mcwi-/- SS-Plekha7em4Mcwi-/Plekha7em4Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2018-09-05) Plekha7em4Mcwi 5143979 1 174249022 174316226 1 - by flanking markers 1 192397589 192463974 1 - by flanking markers 1 185427600 185493985 1 - by flanking markers 1 170364524 170547843 1 - by flanking markers RRID:RGD_5686758 5686760 SS-Plekha7em4Mcwi+/+ SS-Plekha7em4Mcwi+/Plekha7em4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686760 5686762 SS-Plod1em1Mcwi-/- SS-Plod1em1Mcwi-/Plod1em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryorecovery (as of 2018-09-05) RRID:RGD_5686762 5686764 SS-Plod1em1Mcwi+/+ SS-Plod1em1Mcwi+/Plod1em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686764 5686766 SS-Sh2b3em2Mcwi-/- SS-Sh2b3em2Mcwi-/Sh2b3em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Sh2b3em2Mcwi 5509982 12 35954679 35958446 1 - by flanking markers 12 42132947 42136714 1 - by flanking markers 12 40261990 40265757 1 - by flanking markers 12 34749849 34753616 1 - by flanking markers RRID:RGD_5686766 5686768 SS-Slc30a8em1Mcwi-/- SS-Slc30a8em1Mcwi-/Slc30a8em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686768 5686770 SS-Slc30a8em1Mcwi+/+ SS-Slc30a8em1Mcwi+/Slc30a8em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686770 5686772 SS-Slc30a8em2Mcwi-/- SS-Slc30a8em2Mcwi-/Slc30a8em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686772 5686776 SS-Slc30a8em2Mcwi+/+ SS-Slc30a8em2Mcwi+/Slc30a8em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686776 5686778 SS-Stk39em2Mcwi-/- SS-Stk39em2Mcwi-/Stk39em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct (as of 2018-09-05) Stk39em2Mcwi 5509978 3 50249626 50517085 1 - by flanking markers 3 60973443 61244306 1 - by flanking markers 3 54359449 54625702 1 - by flanking markers 3 52913583 53179060 1 - by flanking markers RRID:RGD_5686778 5686780 SS-Stk39em2Mcwi+/+ SS-Stk39em2Mcwi+/Stk39em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686780 5686782 SS-Stk39em2Mcwi-/+ SS-Stk39em2Mcwi-/Stk39em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct (as of 2018-09-05) Stk39em2Mcwi 5509978 3 50249626 50517085 1 - by flanking markers 3 60973443 61244306 1 - by flanking markers 3 54359449 54625702 1 - by flanking markers 3 52913583 53179060 1 - by flanking markers RRID:RGD_5686782 5686784 SS-Tcf7l2em1Mcwi-/- SS-Tcf7l2em1Mcwi-/Tcf7l2em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686784 5686786 SS-Tcf7l2em1Mcwi+/+ SS-Tcf7l2em1Mcwi+/Tcf7l2em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686786 5686788 SS-Tcf7l2em1Mcwi-/+ SS-Tcf7l2em1Mcwi-/Tcf7l2em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686788 5686790 SS-Ulk3em1Mcwi-/- SS-Ulk3em1Mcwi-/Ulk3em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686790 5686792 SS-Ulk3em1Mcwi+/+ SS-Ulk3em1Mcwi+/Ulk3em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686792 5686794 SS-Ulk3em1Mcwi-/+ SS-Ulk3em1Mcwi-/Ulk3em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686794 5686797 SS-Wdr72em1Mcwi-/- SS-Wdr72em1Mcwi-/Wdr72em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5686797 5686799 SS-Wdr72em1Mcwi+/+ SS-Wdr72em1Mcwi+/Wdr72em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5686799 5686826 ACI.FHH-(D1Mit18-D1Rat90)(D3Rat84-D3Rat59)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Eur Triple congenic strain which was generated using the speed congenic strategy by backcrossing ACI/Eur and FHH/Eur parental strains. Rf-1A QTL region of chr 1, Rf-3 QTL region of chr 3, and Rf4 QTL region of chr 14 are introgressed in this strain. Department of Pediatric Surgery, Erasmus Medical Center, Rotterdam, Netherlands congenic Unknown RRID:RGD_5686826 5686829 ACI.FHH-(D1Mit18-D1Rat90)(D3Rat6-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi Triple congenic strain which was generated using the speed congenic strategy by backcrossing ACI.FHH-(D1Mit18-D1Rat90)(D3Rat84-D3Rat59)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Eur and ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/EurMcwi. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown RRID:RGD_5686829 5686832 ACI.FHH-(D1Mit18-D1Rat90)(D3Got102-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi Multicongenic strain which was generated using the speed congenic strategy by backcrossing ACI.FHH-(D1Mit18-D1Rat90)(D3Rat84-D3Rat59)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Eur and ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/EurMcwi. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown RRID:RGD_5686832 5687688 FHH-Tg(CAG-Rab38)1Mcwi A Sleeping Beauty transposon expressing the wild type (BN strain) Rab38 coding sequence under the control of the ubiquitous chicken-actin-globin (CAG) promoter was injected into FHH embryos with a mRNA source of transposase to produce (CAG-Rab38) transgenic on FHH background. This transgene insertion mapped to chromosome 14, roughly 13.2-Mbp, and was more than 100-kbp away from the nearest gene (downstream of Antrx2). Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_5687688 5687689 FHH-Tg(CAG-Rab38)2Mcwi A Sleeping Beauty transposon expressing the wild type (BN strain) Rab38 coding sequence under the control of the ubiquitous chicken-actin-globin (CAG) promoter was injected into FHH embryos with a mRNA source of transposase to produce (CAG-Rab38) transgenic on FHH background. This transgene insertion in line 2 was found to be within a long interspersed nuclear element (LINE) sequence and could not be unambiguously mapped to a specific chromosome location. Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_5687689 5687969 ACI.BN-(D2Rat251-D2Mgh3)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 2 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 2 6332896 63001078 1 - by flanking markers 2 6118364 81156651 1 - by flanking markers 2 6155132 63538449 1 - by flanking markers 2 8634571 62516896 1 - by flanking markers RRID:RGD_5687969 5687971 ACI.BN-(D2Rat10-D2Rat202)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 2 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 2 35874553 51821161 1 - by flanking markers 2 54092967 70871600 1 - by flanking markers 2 34967269 52507805 1 - by flanking markers 2 36023184 51729300 1 - by flanking markers RRID:RGD_5687971 5687973 ACI.BN-(D18Rat30-D18Rat89)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 18 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 18 5682011 63697215 1 - by flanking markers 18 5795276 62092559 1 - by flanking markers 18 5825946 62905769 1 - by flanking markers 18 5584537 60722497 1 - by flanking markers RRID:RGD_5687973 5687974 SS-Chr 5BN-Cyp4a2em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGCTCTATGACCCTGACTatgtgAAGGTGGTTCTGGGAAGAT into SS-Chr 5BN/Mcwi strain rat embryos. The resulting mutation is a 2-bp framesnift deletion in exon 2. PhysGen Knockouts mutant Extinct Cyp4a2em1Mcwi 5687724 5 135765673 135773006 1 - by flanking markers 5 137989327 138000302 1 - by flanking markers 5 134196910 134207888 1 - by flanking markers 5 128922355 128934188 1 - by flanking markers RRID:RGD_5687974 5687975 SS-Prex1em2Mcwi This strain was produced by injecting ZFNs targeting the sequence CAGTACTTCCGCTTCcatgcgGACGAGGAGATGGAA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp frameshift deletion in exon 16. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Prex1em2Mcwi 5687719 3 157693897 157863943 1 - by flanking markers 3 169494331 169575981 1 - by flanking markers 3 163329580 163477822 1 - by flanking markers 3 155306950 155456688 1 - by flanking markers RRID:RGD_5687975 5687977 SS-Acad10em2Mcwi+/+ SS-Acad10em2Mcwi+/Acad10em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5687977 5687979 SS-Acad10em2Mcwi-/- SS-Acad10em2Mcwi-/Acad10em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. The homozygous mutant carries a 10-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-07-18) Acad10em2Mcwi 5131905 12 36070275 36075844 1 - by flanking markers 12 42285817 42328189 1 - by flanking markers 12 40417918 40460562 1 - by flanking markers 12 34901211 34943973 1 - by flanking markers RRID:RGD_5687979 5687981 SS-Alms1em1Mcwi-/- SS-Alms1em1Mcwi-/Alms1em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) Alms1em1Mcwi 5131906 4 119846037 119946085 1 - by flanking markers 4 181947469 182048235 1 - by flanking markers 4 117371544 117472310 1 - by flanking markers 4 118125581 118226005 1 - by flanking markers RRID:RGD_5687981 5687983 SS-Alms1em1Mcwi+/+ SS-Alms1em1Mcwi+/Alms1em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5687983 5687985 SS-Apoeem7Mcwi+/+ SS-Apoeem7Mcwi+/Apoeem7Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct RRID:RGD_5687985 5687987 SS-Apoeem7Mcwi-/- SS-Apoeem7Mcwi-/Apoeem7Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct RRID:RGD_5687987 5687989 SS-Apoeem8Mcwi-/- SS-Apoeem8Mcwi-/Apoeem8Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct RRID:RGD_5687989 5687992 SS-Apoeem8Mcwi+/+ SS-Apoeem8Mcwi+/Apoeem8Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct RRID:RGD_5687992 5687994 SS-Bcas3em4Mcwi+/+ SS-Bcas3em4Mcwi+/Bcas3em4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5687994 5687996 SS-Bcas3em4Mcwi-/- SS-Bcas3em4Mcwi-/Bcas3em4Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5687996 5687998 SS-Cybaem1Mcwi-/- SS-Cybaem1Mcwi-/Cybaem1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5687998 5688000 SS-Cybaem1Mcwi+/+ SS-Cybaem1Mcwi+/Cybaem1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688000 5688002 SS-Chr 5BN-Cyp4a2em1Mcwi+/+ SS-Chr 5BN-Cyp4a2em1Mcwi+/Cyp4a2em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct RRID:RGD_5688002 5688004 SS-Chr 5BN-Cyp4a2em1Mcwi-/- SS-Chr 5BN-Cyp4a2em1Mcwi-/Cyp4a2em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct RRID:RGD_5688004 5688006 SS-Chr 5BN-Cyp4a2em1Mcwi-/+ SS-Chr 5BN-Cyp4a2em1Mcwi-/Cyp4a2em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct RRID:RGD_5688006 5688008 SS-Ets1em1Mcwi+/+ SS-Ets1em1Mcwi+/Ets1em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688008 5688010 SS-Ets1em1Mcwi-/+ SS-Ets1em1Mcwi-/Ets1em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) Ets1em1Mcwi 4139856 8 32481694 32545237 1 - by flanking markers 8 33798598 33921593 1 - by flanking markers 8 33756634 33879625 1 - by flanking markers 8 31045909 31168010 1 - by flanking markers RRID:RGD_5688010 5688012 SS-Gpr183em1Mcwi-/- SS-Gpr183em1Mcwi-/Gpr183em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5688012 5688014 SS-Gpr183em1Mcwi+/+ SS-Gpr183em1Mcwi+/Gpr183em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688014 5688016 SS-Gpr183em2Mcwi-/- SS-Gpr183em2Mcwi-/Gpr183em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5688016 5688018 SS-Gpr183em2Mcwi+/+ SS-Gpr183em2Mcwi+/Gpr183em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688018 5688020 SS-Gpr183em3Mcwi-/- SS-Gpr183em3Mcwi-/Gpr183em3Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5688020 5688022 SS-Gpr183em3Mcwi+/+ SS-Gpr183em3Mcwi+/Gpr183em3Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688022 5688024 SS-Itga9em1Mcwi+/+ SS-Itga9em1Mcwi+/Itga9em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688024 5688026 SS-Mas1em1Mcwi+/+ SS-Mas1em1Mcwi+/Mas1em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688026 5688028 SS-Mas1em1Mcwi-/- SS-Mas1em1Mcwi-/Mas1em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryorecovery (as of 2017-07-18) RRID:RGD_5688028 5688039 SS-Mthfrem1Mcwi+/+ SS-Mthfrem1Mcwi+/Mthfrem1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688039 5688041 SS-Mthfrem1Mcwi-/+ SS-Mthfrem1Mcwi-/Mthfrem1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5688041 5688043 SS-Nckap5em1Mcwi-/- SS-Nckap5em1Mcwi-/Nckap5em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct (as of 2018-09-05) Nckap5em1Mcwi 4139859 13 38444115 39275959 1 - by flanking markers 13 47369687 48273649 1 - by flanking markers 13 42265875 43049232 1 - by flanking markers 13 37369948 38283257 1 - by flanking markers RRID:RGD_5688043 5688045 SS-Nckap5em1Mcwi+/+ SS-Nckap5em1Mcwi+/Nckap5em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688045 5688047 SS-Nckap5em2Mcwi-/- SS-Nckap5em2Mcwi-/Nckap5em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct (as of 2018-09-05) Nckap5em2Mcwi 4139862 13 38444115 39275959 1 - by flanking markers 13 47369687 48273649 1 - by flanking markers 13 42265875 43049232 1 - by flanking markers 13 37369948 38283257 1 - by flanking markers RRID:RGD_5688047 5688049 SS-Nckap5em2Mcwi+/+ SS-Nckap5em2Mcwi+/Nckap5em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688049 5688051 SS-Nckap5em3Mcwi-/- SS-Nckap5em3Mcwi-/Nckap5em3Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Extinct (as of 2018-09-05) Nckap5em3Mcwi 4139861 13 38444115 39275959 1 - by flanking markers 13 47369687 48273649 1 - by flanking markers 13 42265875 43049232 1 - by flanking markers 13 37369948 38283257 1 - by flanking markers RRID:RGD_5688051 5688053 SS-Nckap5em3Mcwi+/+ SS-Nckap5em3Mcwi+/Nckap5em3Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688053 5688059 SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi-/- SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi-/Nckap5em4Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688059 5688061 SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi+/+ SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi+/Nckap5em4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688061 5688063 SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi-/+ SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi-/Nckap5em4Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688063 5688066 SS-Ncf2em1Mcwi-/- SS-Ncf2em1Mcwi-/Ncf2em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2018-09-05) Ncf2em1Mcwi 5144089 13 67806516 67834105 1 - by flanking markers 13 75197561 75229600 1 - by flanking markers 13 70226441 70259019 1 - by flanking markers 13 64955502 64986289 1 - by flanking markers RRID:RGD_5688066 5688069 SS-Ncf2em1Mcwi+/+ SS-Ncf2em1Mcwi+/Ncf2em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688069 5688074 SS-Nox4em2Mcwi-/- SS-Nox4em2Mcwi-/Nox4em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. This homozygous mutant carries an 8-bp frameshift deletion in exon 7 of rat Nox4. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2019-01-03) Nox4em2Mcwi 4139868 1 143415816 143603554 1 - by flanking markers 1 157106652 157285107 1 - by flanking markers 1 150796359 150976186 1 - by flanking markers 1 140900886 141078844 1 - by flanking markers RRID:RGD_5688074 5688077 SS-Nox4em2Mcwi+/+ SS-Nox4em2Mcwi+/Nox4em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688077 5688080 SS-Nox4em2Mcwi-/+ SS-Nox4em2Mcwi-/Nox4em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2019-07-26) Nox4em2Mcwi 4139868 1 143415816 143603554 1 - by flanking markers 1 157106652 157285107 1 - by flanking markers 1 150796359 150976186 1 - by flanking markers 1 140900886 141078844 1 - by flanking markers RRID:RGD_5688080 5688083 SS-Prex1em2Mcwi-/- SS-Prex1em2Mcwi-/Prex1em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5688083 5688087 FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi-/- FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi-/Rab38em1Mcwi- ZFN mutant founders were backcrossed with FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi to get heterozygous offspring which were intercrossed and offspring maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Rab38em1Mcwi 4139867 1 144783919 144864573 1 - by flanking markers 1 158385888 158466621 1 - by flanking markers 1 152072716 152153449 1 - by flanking markers 1 142182566 142262923 1 - by flanking markers RRID:RGD_5688087 5688090 FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi+/+ FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi+/Rab38em1Mcwi+ ZFN mutant founders were backcrossed with FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown Rab38 628752 1 144783919 144864573 1 - by flanking markers 1 158385888 158466621 1 - by flanking markers 1 152072716 152153449 1 - by flanking markers 1 142182566 142262923 1 - by flanking markers RRID:RGD_5688090 5688092 SS-Rag1em1Mcwi-/- SS-Rag1em1Mcwi-/Rag1em1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5688092 5688094 SS-Rag1em1Mcwi+/+ SS-Rag1em1Mcwi+/Rag1em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688094 5688096 SS-Rag1em2Mcwi-/- SS-Rag1em2Mcwi-/Rag1em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5688096 5688098 SS-Rag1em2Mcwi+/+ SS-Rag1em2Mcwi+/Rag1em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688098 5688100 SS-Renem1Mcwi+/+ SS-Renem1Mcwi+/Renem1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688100 5688102 SS-Renem1Mcwi-/- SS-Renem1Mcwi-/Renem1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2018-09-05) Renem1Mcwi 4139863 13 46262936 46275213 1 - by flanking markers 13 55555583 55566812 1 - by flanking markers 13 50502724 50513953 1 - by flanking markers 13 44796260 44807491 1 - by flanking markers RRID:RGD_5688102 5688107 FHH-Chr 1BN-Sorcs1em1Mcwi-/- FHH-Chr 1BN-Sorcs1em1Mcwi-/Sorcs1em1Mcwi- ZFN mutant founders were backcrossed with FHH-Chr 1BN/Mcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. The resulting mutation is a 14-bp frameshift deletion mutation in exon 7. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Sorcs1em1Mcwi 4139864 1 255767411 256279565 1 - by flanking markers 1 277404996 277912261 1 - by flanking markers 1 269965824 270473097 1 - by flanking markers 1 249080662 249594520 1 - by flanking markers RRID:RGD_5688107 5688109 FHH-Chr 1BN-Sorcs1em1Mcwi+/+ FHH-Chr 1BN-Sorcs1em1Mcwi+/Sorcs1em1Mcwi+ ZFN mutant founders were backcrossed with FHH-Chr 1BN/Mcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688109 5688111 SS-Tfdp2em2Mcwi-/- SS-Tfdp2em2Mcwi-/Tfdp2em2Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5688111 5688113 SS-Tfdp2em2Mcwi+/+ SS-Tfdp2em2Mcwi+/Tfdp2em2Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688113 5688116 SS-Tgfb1em1Mcwi+/+ SS-Tgfb1em1Mcwi+/Tgfb1em1Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offspring which were intercrossed and offspring maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688116 5688119 SS-Tgfb1em3Mcwi+/- SS-Tgfb1em3Mcwi+/Tgfb1em3Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-08-24) RRID:RGD_5688119 5688121 SS-Ube2q2em3Mcwi-/- SS-Ube2q2em3Mcwi-/Ube2q2em3Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5688121 5688123 SS-Ube2q2em3Mcwi+/+ SS-Ube2q2em3Mcwi+/Ube2q2em3Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_5688123 5688125 SS-Ulk4em3Mcwi-/- SS-Ulk4em3Mcwi-/Ulk4em3Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2018-09-05) RRID:RGD_5688125 5688396 ACI.BN-(D3Rat80-D3Rat3)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 3 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 3 32056563 162589029 1 - by flanking markers 3 41713824 175796738 1 - by flanking markers 3 36599933 169714239 1 - by flanking markers 3 35528428 160482157 1 - by flanking markers RRID:RGD_5688396 5688400 ACI.BN-(D4Rat5-D4Got131)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 4 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 4 9638281 162284199 1 - by flanking markers 4 10720881 224994372 1 - by flanking markers 4 10728623 157981900 1 - by flanking markers 4 14118904 158261065 1 - by flanking markers RRID:RGD_5688400 5688402 ACI.BN-(D6Rat148-D6Rat109)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 6 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 6 20826657 146162691 1 - by flanking markers 6 31958575 155686896 1 - by flanking markers 6 22070168 146778380 1 - by flanking markers 6 20894065 139809723 1 - by flanking markers RRID:RGD_5688402 5688405 ACI.COP-(D5Rat12-D5Rat205)/Shul This congenic strain contains a region of COP/CrCrl chromosome 5 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 70669803 70670361 1 - by flanking markers 5 74199071 74199222 1 - by flanking markers 5 70038765 70038916 1 - by flanking markers 5 67856776 67856928 1 - by flanking markers RRID:RGD_5688405 5688407 ACI.COP-(D5Rat28-D5Rat205)/Shul This congenic strain contains a region of COP/CrCrl chromosome 5 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 126963761 126963962 1 - by flanking markers 5 129313212 129313302 1 - by flanking markers 5 125455818 125455908 1 - by flanking markers 5 120740824 120740915 1 - by flanking markers RRID:RGD_5688407 5688409 ACI.COP-(D5Rat28-D5Rat36)/Shul This congenic strain contains a region of COP/CrCrl chromosome 5 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 5 126963761 145187034 1 - by flanking markers 5 129313212 147610238 1 - by flanking markers 5 125455818 143846372 1 - by flanking markers 5 120740824 138113774 1 - by flanking markers RRID:RGD_5688409 6218997 SHR/NCrlAnra These were originally from Harvard University, Boston MA, then at UNESP, Botucatu, SP, Brazil, now maintained at Behavior Genetics Laboratory, SC, Brazil Behavior Genetics Laboratory, Departamento de Biologia Celular, Embriologia e Genetica, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil inbred Unknown RRID:RGD_6218997 6219002 LEW/HsdUnibAnra LEW rats originally from Harlan Sprague Dawley, IN then bred at UNICAMP (Campinas, SP Brazil) now maintained at Behavior Genetics Laboratory, SC, Brazil Behavior Genetics Laboratory, Departamento de Biologia Celular, Embriologia e Genetica, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil inbred Unknown RRID:RGD_6219002 6478788 STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc p53 knockout rat This strain was made by electroporation of DAc8 embryonic stem cells with a targeting vector containing 6.7kb 5 prime and 1.6- kb 3 prime homology arms and a CAG-EGFP-IRES-Pac cassette. Chimeras were formed by microinjecting F344 blastocysts. Founder animals were mated with SD rats. Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-02-01) Tp53|Tp53tm1(EGFP-Pac)Qly 3889|12792957 10 56399721 56411150 1 - by flanking markers 10 55932658 55944087 1 - by flanking markers 10 56186299 56198449 1 - by flanking markers 10 54300070 54311525 1 - by flanking markers RRID:RRRC_00485 6478789 LEW-Tg(CAG-EGFP)YsRrrc Transgene prepared from cDNA fragment of EGFP derived from pEGFP vector (No. 6077-1, Clontech Laboratories, Inc., Palo Alto, CA) and pCXN2 expression vector containing cytomegalovirus enhancer, chicken b-actin enhancer-promoter and rabbit b-globin poly(A) signal. Rat Resource and Research Center transgenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2018-07-16) RRID:RRRC_00296 6478791 F344-Tg(UBC-EGFP)F455Rrrc This transgenic strain was made by injecting the lentivirus vector containing the GFP construct (vector name FUGW) into Lewis rat embryos. Animals that exhibited fluorescence of tails were mated. Offspring were bred with Lewis wild-type mates to map transgene location. Animals were backcrossed 10 generations onto F344. Rat Resource and Research Center transgenic Live Animals; Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00307 6480190 NAft:HS Heterogeneous stock From Dr. Eva Redei, Center for Comparative Medicine, Northwestern University to Dr. Alberto Fernandez-Teruel, Barcelona Psychiatry and Forensic Medicine, Institute of Neurosciences, School of Medicine, Autonomous University of Barcelona, Barcelona, Spain outbred Unknown RRID:RGD_6480190 6480205 MWF-Chr 6SHR Chr 8SHR/Rkb Chr 8 and chr 6 were introgressed from albuminuria-resistant SHR/FubRkb into the sensitive isogenic background of MWF/FubRkb Department of Clinical Pharmacology and Toxicology, Charite-Universitatsmedizin Berlin, Berlin, Germany consomic Unknown RRID:RGD_6480205 6480210 SHR-Chr 8MWF/Rkb SHR/FubRkb male was crossed with female MWF/FubRkb to get F1 animals which in turn were backcrossed with female SHR/FubRkb, this was repeated for 7 generations, tested by sequential marker-assisted backcrossing Department of Clinical Pharmacology and Toxicology, Charite-Universitatsmedizin Berlin, Berlin, Germany consomic Unknown RRID:RGD_6480210 6480218 AR-Ednrbsl/Hkv Aganglionosis rat Congenital megacolon rats were found in offspring of a female albino rat crossed with a wild male by Ikadai et al. at Institute for Animal Reproduction in 1973 and were named Aganglionosis Rat (AR), provided to Dr. Takashi Agui by Dr. Ozaki, National Institute for Physiological Sciences, Okazaki, Japan Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan mutant Unknown Ednrbsl 10755424 15 87893141 87898700 1 - by flanking markers 15 91500400 91531979 1 - by flanking markers 15 88004775 88036354 1 - by flanking markers 15 80640839 80672115 1 - by flanking markers RRID:RGD_6480218 6480220 LE/Hkv.AR-Ednrbsl Aganglionosis rat This strain derived from AR (aganglionosis) rat found by Dr. Ikadai in 1973. AR-derived Ednrbsl was introduced into Long-Evans by Dr. Ozaki (NBRP-Rat # 0557 LE.AR-EdnrbSl/Okkm), and this rat was provided to Dr. Agui at Hokkaido University and inbred line was established by sib mating. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan, National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2016-11-15) Internal Medicine Ednrbsl 10755424 15 87893141 87898700 1 - by flanking markers 15 91500400 91531979 1 - by flanking markers 15 88004775 88036354 1 - by flanking markers 15 80640839 80672115 1 - by flanking markers RRID:RGD_6480220 6480223 F344.AR-Ednrbsl/Hkv Aganglionosis rat This strain derived from AR (aganglionosis) rat found by Dr. Ikadai in 1973. This congenic strain was established by backcrossing (over 10 generations) of AR rat to F344/NSlc. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan, National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2016-10-28) Ednrbsl 10755424 15 87893141 87898700 1 - by flanking markers 15 91500400 91531979 1 - by flanking markers 15 88004775 88036354 1 - by flanking markers 15 80640839 80672115 1 - by flanking markers RRID:RGD_6480223 6480863 BBDR/RhwRrrc BBDR/Rhw from R. H. William Laboratory, University of Washington, Seattle, Washington to Rat Resource & Research Center Rat Resource & Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00463 6480866 BN-Chr 13LH/MavRrrc Chr 13 from LH/Mav was introgressed onto the genetic background of BN/NHsdMcwi and then genotyped Laboratoire de Physiologie, Lyon Cedex , France, Rat Resource & Research Center consomic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00395 6480868 BN-Chr 2LH/MavRrrc Chr 2 from LH/Mav was introgressed onto the genetic background of BN/NHsdMcwi and then genotyped Laboratoire de Physiologie, Lyon Cedex , France, Rat Resource & Research Center consomic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00396 6480874 COP.DA-(D16Rat12-D16Rat90)/McoRrrc Male COP/OlaHsd were crossed with female DA/OlaHsd then the F1 males were backcrossed to COP females. Male progeny containing the fewest number of DA-alleles were backcrossed to female COP. These males were backcrossed to female COP. Transferred from Medical College of Toledo to Rat Resource & Research Center Rat Resource & Research Center congenic Cryopreserved Embryo; Cryopreserved Sperm 16 350121 85734479 1 - by flanking markers 16 1084304 85597057 1 - by flanking markers 16 1090054 86162972 1 - by flanking markers 16 380245 80345693 1 - by flanking markers RRID:RRRC_00444 6482243 WI-CitfhJjlo/Rrrc flathead rat Flathead rat was discovered at University of Connecticut in an inbred colony of Wistar rats. Spontaneous single G deletion in exon 1 of citron kinase (Cit) confers a premature stop codon and lack of citron kinase protein. Department of Physiology and Neurobiology, University of Connecticut, Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2017-07-21) CitfhJjlo 13204831 12 41858134 42019601 1 - by flanking markers 12 48136329 48295119 1 - by flanking markers 12 46334669 46494152 1 - by flanking markers 12 40603073 40764846 1 - by flanking markers RRID:RRRC_00322 6482244 SS-Tg(APOA1)116OpazRrrc SS/JrHsd embryos were microinjected with human APOA1 C3 promoter Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00282 6482245 SS-Tg(Atp1a1)24OpazRrrc SS/JrHsd embryos were microinjected with rat alpha1 Na,K-ATPase promoter (-1288 5 flanking regulatory region isolated from Sprague Dawley genomic library); transgene cDNA: Dahl R alpha1 Na,K-ATPase Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-05-24) RRID:RRRC_00280 6482247 FDIO/Rrrc Cross between F344 (lean phenotype) and SDDIO (diet-induced obese phenotype) then inbred for 6 generations with maintenance of obese phenotype. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm (as of 2022-10-18) RRID:RRRC_00060 6482252 F344-Tg(Pgk1-EGFP)/Rrrc Multiple random integration of EGFP gene under the control of the PGK promoter. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00053 6482254 Gunn-Ugt1a1j/BluHsdRrrc Gunn rat This mutation was first observed in normal Wistar albino rats in a breeding colony at Cannaught Laboratories in 1934. Jaundice was evident at birth or shortly after and was persistant throughout life. Rat Resource and Research Center mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-09-15) Ugt1a1j 13432064 9 87091241 87098362 1 - by flanking markers 9 94982916 94990037 1 - by flanking markers 9 95295701 95302822 1 - by flanking markers 9 88801344 88808465 1 - by flanking markers RRID:RRRC_00341 6482256 HS/Rrrc High Self-Administration Developed from selective breeding of outbred Wistar rats. Selectively bred over six generations for increased intravenous drug self-administration with subsequent inbreeding within this strain over six generations. Rat Resource and Research Center inbred Cryorecovery (as of 2019-02-01) RRID:RRRC_00537 6482259 LS/Rrrc Low Self-Administration Developed from selective breeding of outbred Wistar rats. Selectively bred over six generations for increased intravenous drug self-administration with subsequent inbreeding within this strain over six generations. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2017-01-13) RRID:RRRC_00536 6482268 BRAT-Avpdi/BluHsdRrrc Brattleboro Hereditary hypothalamic diabetes insipidus was first described in offspring from a Long-Evans stock of rats by Dr. Schroeder, later named Brattleboro strain. In 1964 from Dr. Lewis Kinder, Harvard University, Boston to Blue Spruce Farms, Altamont, New York. to Harlan through acquisition in 1988. Brattleboro rats transferred to the RRRC in 2009. Rat Resource and Research Center mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-06-21) Avpdi 13627261 3 118205007 118206985 1 - by flanking markers 3 129615610 129627147 1 - by flanking markers 3 123117482 123119460 1 - by flanking markers 3 117793447 117805091 1 - by flanking markers RRID:RRRC_00445 6482271 LEW.Cg-Foxn1rnu/NRrrc The NIH nude rat was developed in 1979-1980 at the NIH through a series of matings involving the following inbred rat strains: BN/SsN, MR/N, BUF/N, WN/N, ACI/N, WKY/N, M520/N, and F344/N. Received from the National Institute of Health by NCI in 1983. The nude mutation was subsequently backcrossed 17 generations to the Lewis inbred strain. Rat Resource and Research Center congenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00363 6482282 LEW-Tg(EGFP)463-5Rrrc Lewis- GFP transgenic insertion of EGFP transgene with Ubiquitin C promoter Rat Resource and Research Center transgenic Cryopreserved Sperm RRID:RRRC_00083 6482284 LEW-Tg(EGFP)456-9Rrrc Lewis- GFP transgenic insertion of EGFP transgene with Ubiquitin C promoter Rat Resource and Research Center transgenic Cryopreserved Sperm RRID:RRRC_00084 6482286 LEW-Tg(EGFP)458-7Rrrc Lewis- GFP transgenic insertion of EGFP transgene with Ubiquitin C promoter Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00086 6482288 LEW-Tg(EGFP)463-1Rrrc Lewis- GFP transgenic insertion of EGFP transgene with Ubiquitin C promoter Rat Resource and Research Center transgenic Cryopreserved Sperm RRID:RRRC_00085 6482290 LEW-Tg(EGFP)455Rrrc Lewis- GFP transgenic This transgenic strain contains the enhanced green fluorescent protein gene under the control of the human ubiquitin-C promoter with a the woodchuck hepatitis virus posttranscriptional regulatory element (WRE). This transgenic strain was made by injecting the lentivirus vector containing the GFP construct (vector name FUGW) into Lewis rat embryos. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00062 6482292 LEW-Tg((ROSA26)Sor-lacZ)15Jmsk This strain expresses LacZ ubiquitously driven by the ROSA26 promoter established at Jichi Medical School. Rat Resource and Research Center transgenic Cryopreserved Embryo (as of 2017-08-08) RRID:RRRC_00297 6482294 LH-Chr 13BN/MavRrrc Chr 13 from BN/NHsdMcwi was introgressed onto the genetic background of LH/Mav and then genotyped Rat Resource and Research Center consomic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00393 6482296 LH-Chr 17BN/MavRrrc Chr 17 from BN/NHsdMcwi was introgressed onto the genetic background of LH/Mav and then genotyped Rat Resource and Research Center consomic Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00394 6482298 MWF/ZtmRrrc Munich Wistar Fromter From outbred Wistar rats selected for large numbers of superficial glomeruli. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-02-01) RRID:RRRC_00482 6482643 WIN/RhwRrrc Submitted to Rat Resource & Research Center Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00481 6482645 SD-Tg(Rho-S334X)3LavRrrc This transgenic strain carries a mouse rhodopsin gene that bears a termination codon at residue 334, which encodes a C-terminal truncated rhodopsin protein. Submitted to Rat Resource & Research Center Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-08-17) RRID:RRRC_00539 6482654 ACI.BN-(D7Rat36-D7Rat11)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 7 1526177 118826810 1 - by flanking markers 7 2632014 121752141 1 - by flanking markers 7 2653138 121762010 1 - by flanking markers 7 664270 112087821 1 - by flanking markers RRID:RGD_6482654 6482674 HIS/NdkRrrc High-Saccharin-Consuming (HiS) Rat The Occidental HiS (high-saccharin-consuming) rat strain was developed from a male Holtzman Sprague-Dawley rat that voluntarily consumed high levels of saccharin.This male was mated to several Holtzman Sprague-Dawley females and offspring displaying high saccharin consumption were selected. Selective breeding was continued in which offspring with high saccharin consumption were bred. To maintain the outbred status of this colony the donor backcrosses to Hsd:SD every 4-6 generations. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00366 6482676 LOS/NdkRrrc Low-Saccharin-Consuming (HiS) Rat The Occidental LoS (low-saccharin-consuming) rat strain was developed from a male Holtzman Sprague-Dawley rat that did not voluntarily consume saccharin. This male was mated to several Holtzman Sprague-Dawley females and offspring displaying low saccharin consumption were selected. Selective breeding was continued in which offspring with low saccharin consumption (see phenotyping protocol) were bred. To maintain the outbred status of this colony the donor backcrosses to Hsd:SD every 4-6 generations. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm RRID:RRRC_00440 6482680 SD-Tg(MMTV-Erbb2)1UwmRrrc Hsd:SD background carrying a transgene which produces over-expression of the rat Erbb2 proto-oncogene under the control of the mouse mammary tumor virus (MMTV) long terminal repeat. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-04-12) Erbb2 2561 RRID:RRRC_00365 6483453 SS-Dguokem2Mcwi This allele was made by ZFN mutagenesis. The resulting mutation is a 37-bp frameshift deletion in exon 1 (del 74-110) Medical College of Wisconsin, Milwaukee WI mutant Cryopreserved Sperm (as of 2021-11-03) Dguokem2Mcwi 5508354 4 117697251 117725383 1 - by flanking markers 4 179770727 179798683 1 - by flanking markers 4 115180433 115208061 1 - by flanking markers 4 115987101 116014733 1 - by flanking markers RRID:RGD_6483453 6483454 SS-Dguokem1Mcwi This allele was made by ZFN mutagenesis. The resulting mutation is a 32-bp frameshift deletion in exon 1 (del 74-105) Medical College of Wisconsin, Milwaukee WI mutant Cryopreserved Sperm (as of 2017-01-26) Dguokem1Mcwi 5508345 4 117697251 117725383 1 - by flanking markers 4 179770727 179798683 1 - by flanking markers 4 115180433 115208061 1 - by flanking markers 4 115987101 116014733 1 - by flanking markers RRID:RGD_6483454 6483455 SS-Dguokem3Mcwi This allele was made by ZFN mutagenesis. The resulting mutation is a net 57-bp frameshift deletion in exon 1 (del 3-102, ins. GCTTAGCAAGGCGGGCACTTCCGCCgagggcacttccgcctgc) Medical College of Wisconsin, Milwaukee WI mutant Cryopreserved Sperm Dguokem3Mcwi 5508325 4 117697251 117725383 1 - by flanking markers 4 179770727 179798683 1 - by flanking markers 4 115180433 115208061 1 - by flanking markers 4 115987101 116014733 1 - by flanking markers RRID:RGD_6483455 6483846 HsdFcen:WI Wistar Descendants of rats from the Wistar Institute, Philadelphia, Pennsylvania then to Harlan and now maintained at School of Science, Buenos Aires University, Ciudad Universitaria, Buenos Aires, Capital Federal, Argentina Buenos Aires University, Ciudad Universitaria, Buenos Aires, Capital Federal, Argentina outbred Unknown RRID:RGD_6483846 6484519 SS-ROSA26em1(SB11)Mcwi This strain was produced by ZFN-stimulated knockin in the rat Rosa26 locus. ZFNs targeting the sequence CCTTCCCCCTTCTTCcctcgtGATCTGCAACTGGAGTCT were injected into SS/JrHsdMcwi rat embryos along with a plasmid template incorporating the Engrailed-2 mouse splice acceptor, a loxP site, the SB11 Sleeping Beauty transposase cDNA, and SV40 polyadenylation signal to integrate the transgene by homologous recombination. The resulting animal was confirmed by sequencing both junctions to harbor the SB11 gene knocked into the rat locus and expresses SB11 transposase in every cell by immunohistochemistry. PhysGen Knockouts mutant Cryorecovery (as of 2017-08-08) Rosa26em1(SB11)Mcwi 6484518 RRID:RGD_6484519 6484559 SS-Slc34a1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CGTGCTCAGCTCTGCCTTccaactGGCCGGAGGTAGGGCCCG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 12-bp deletion in exon 4. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Slc34a1em1Mcwi 5687699 17 15262929 15277902 1 - by flanking markers 17 11856946 11872100 1 - by flanking markers 17 9747766 9762739 1 - by flanking markers 17 9218876 9233852 1 - by flanking markers RRID:RGD_6484559 6484560 SS-Pdcem2Mcwi This strain was produced by injecting ZFNs targeting the sequence CACCACCATCGTGGTtaacaTTTACGAGGATGGTGTCAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp deletion in exon 5. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Pdcem2Mcwi 5687695 13 64622473 64636031 1 - by flanking markers 13 72510251 72523421 1 - by flanking markers 13 67545430 67558600 1 - by flanking markers 13 62297281 62371754 1 - by flanking markers RRID:RGD_6484560 6484561 SS-Comtem1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGTTCCAGGTCACCATCctcaatGGGGCATCCCAGGATCTT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Comtem1Mcwi 5687725 11 84561591 84581713 1 - by flanking markers 11 89809853 89829568 1 - by flanking markers 11 86715981 86735630 1 - by flanking markers 11 82568052 82587642 1 - by flanking markers RRID:RGD_6484561 6484562 SS-Fgf5em1Mcwi This strain was produced by injecting ZFNs targeting the sequence TGGATCCCACGAAGCcagtgtGTTAAGTAAGTTGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Fgf5em1Mcwi 5687720 14 12713971 12734634 1 - by flanking markers 14 12917742 12938879 1 - by flanking markers 14 12974921 12996046 1 - by flanking markers 14 11325334 11346570 1 - by flanking markers RRID:RGD_6484562 6484563 SS-Cst3em3Mcwi This strain was produced by injecting ZFNs targeting the sequence CTTCGCCGTAAGCGAGTAcaacaaGGGCAGCAACGAT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp insertion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Cst3em3Mcwi 5687738 3 137650903 137654776 1 - by flanking markers 3 149628692 149632565 1 - by flanking markers 3 143219671 143223544 1 - by flanking markers 3 136336923 136340796 1 - by flanking markers RRID:RGD_6484563 6484564 SS-Cd247em3Mcwi This strain was produced by injecting ZFNs targeting the sequence CTCGCCTGCATCCTTCAAGtgcagtTCCCAGGAGCAGGTAAGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Cd247em3Mcwi 5687730 13 81515383 81594699 1 - by flanking markers 13 88876046 88951003 1 - by flanking markers 13 83996045 84071408 1 - by flanking markers 13 78043302 78118437 1 - by flanking markers RRID:RGD_6484564 6484565 SS-Ldlrem3Mcwi This strain was produced by injecting ZFNs targeting the sequence TGCATCCCCAGCCTGTGGgcctgcGACGGGGACCGGGAC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 12-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Ldlrem3Mcwi 5144082 8 20824040 20846920 1 - by flanking markers 8 22804325 22827199 1 - by flanking markers 8 22750425 22773305 1 - by flanking markers 8 20270020 20292981 1 - by flanking markers RRID:RGD_6484565 6484566 SS-Slc6a12em1Mcwi This strain was produced by injecting ZFNs targeting the sequence GTCTCCCTCTCCAGTatggacAGAAAGGTTACAGTC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 53-bp deletion overlapping exon 2 PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Slc6a12em1Mcwi 5687736 4 157781178 157800038 1 - by flanking markers 4 221009224 221029242 1 - by flanking markers 4 153921199 153941333 1 - by flanking markers 4 154585386 154603750 1 - by flanking markers RRID:RGD_6484566 6484567 FHH-Chr 1BN-Sorcs3em1Mcwi This strain was produced by injecting ZFNs targeting the sequence TGCCCGCTCCATTGAcatcagtTCCCTGGTCGTCCAGGAT into FHH-Chr 1BN/Mcwi rat embryos. The resulting mutation is a 33-bp insertion in exon 7 PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Sorcs3em1Mcwi 5687731 1 254125935 254345330 1 - by flanking markers 1 275416357 276060204 1 - by flanking markers 1 267986305 268620331 1 - by flanking markers 1 247099178 247734027 1 - by flanking markers RRID:RGD_6484567 6484568 SS-Cd247em5Mcwi This strain was produced by injecting ZFNs targeting the sequence CTCGCCTGCATCCTTCAAGtgcagtTCCCAGGAGCAGGTAAGG into SS/JrHsdMcwi rat embryos. The resulting mutation is an 8-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Extinct Cd247em5Mcwi 5687713 13 81515383 81594699 1 - by flanking markers 13 88876046 88951003 1 - by flanking markers 13 83996045 84071408 1 - by flanking markers 13 78043302 78118437 1 - by flanking markers RRID:RGD_6484568 6484569 SS-Adora2bem1Mcwi This strain was produced by injecting ZFNs targeting the sequence AACTACTTTCTGGTGTccctgGCGACGGCGGACGTGGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 114-bp deletion in exon 1 PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Adora2bem1Mcwi 5687729 10 48421592 48437967 1 - by flanking markers 10 48358068 48374871 1 - by flanking markers 10 48569563 48586366 1 - by flanking markers 10 46940394 46956772 1 - by flanking markers RRID:RGD_6484569 6484570 SS-Stc1em2Mcwi This strain was produced by injecting ZFNs targeting the sequence CAGCTGCCCAATCACttctccAACAGGTATCCTGAGGGT into SS/JrHsdMcwi rat embryos. The resulting mutation is an 8-bp frameshift deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Stc1em2Mcwi 5687722 15 49566885 49577539 1 - by flanking markers 15 54622230 54632884 1 - by flanking markers 15 50891137 50901791 1 - by flanking markers 15 44299591 44311695 1 - by flanking markers RRID:RGD_6484570 6484571 SS-Myadml2em5Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGATGGGCAGCACCATGgaccccCCGGGGGGTGCA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 31-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Myadml2em5Mcwi 5687726 10 110039330 110040967 1 - by flanking markers 10 109418559 109420196 1 - by flanking markers 10 109822170 109827328 1 - by flanking markers 10 105922557 105927867 1 - by flanking markers RRID:RGD_6484571 6484572 SS-Fgf5em5Mcwi This strain was produced by injecting ZFNs targeting the sequence TGGATCCCACGAAGCcagtgtGTTAAGTAAGTTGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 2-bp deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Fgf5em5Mcwi 5687727 14 12713971 12734634 1 - by flanking markers 14 12917742 12938879 1 - by flanking markers 14 12974921 12996046 1 - by flanking markers 14 11325334 11346570 1 - by flanking markers RRID:RGD_6484572 6484573 SS-Clcn6em2Mcwi This strain was produced by injecting ZFNs targeting the sequence GTCCCTGGTGACGACtgtggtGGTGTTTGTGGCCTCCATG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 15-bp frameshift deletion in exon 13. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Clcn6em2Mcwi 5687740 5 165079773 165110594 1 - by flanking markers 5 168469718 168502323 1 - by flanking markers 5 164811815 164844554 1 - by flanking markers 5 158434299 158465174 1 - by flanking markers RRID:RGD_6484573 6484574 SS-Umodem1Mcwi This strain was produced by injecting ZFNs targeting the sequence CACCACATGCTCCTGccaggCAGGCTTCACTGGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 104-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Extinct Umodem1Mcwi 5687697 1 177729212 177742552 1 - by flanking markers 1 196127939 196141822 1 - by flanking markers 1 189186027 189199939 1 - by flanking markers 1 173816341 173829681 1 - by flanking markers RRID:RGD_6484574 6484575 SS-Resp18em3Mcwi This strain was produced by injecting ZFNS targeting the sequence CTCAGCAGACTCCATCCCCagtatcCATGCCGGAAGGAGGGGAA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp substitution in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Resp18em3Mcwi 5687714 9 74551809 74558151 1 - by flanking markers 9 82240055 82246695 1 - by flanking markers 9 82470794 82477136 1 - by flanking markers 9 76765179 76771824 1 - by flanking markers RRID:RGD_6484575 6484576 SS-Adipoqem1Mcwi This strain was produced by injecting ZFNs targeting the sequence CAGGCATCCCAGGATATCctggtcACAATGGGATACCGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 47-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-13) Adipoqem1Mcwi 5687709 11 79908291 79911065 1 - by flanking markers 11 84363940 84382663 1 - by flanking markers 11 81330845 81344488 1 - by flanking markers 11 77721912 77735644 1 - by flanking markers RRID:RGD_6484576 6484577 SS-Gnb3em1Mcwi This strain was produced by injecting ZFNs targeting the sequence GGCTCCCTCTCTCCTGGCagtccTTGTGGGACATTGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 111-bp deletion overlapping exon 7. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Gnb3em1Mcwi 5687696 4 160957524 160963226 1 - by flanking markers 4 224370234 224376918 1 - by flanking markers 4 157352558 157359237 1 - by flanking markers 4 157639468 157645171 1 - by flanking markers RRID:RGD_6484577 6484578 SS-Mylipem1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGATGGGCAGCACCATGgaccccCCGGGGGGTGCA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 47-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Mylipem1Mcwi 5508347 17 25308147 25329887 1 - by flanking markers 17 21703590 21725205 1 - by flanking markers 17 19682040 19703681 1 - by flanking markers 17 19286649 19308295 1 - by flanking markers RRID:RGD_6484578 6484579 SS-Chr 5BN-Cyp4a3em3Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGCTCTATGACCCTGACTatgtgAAGGTGGTTCTGGGAAGAT into SS-Chr 5BN/Mcwi strain rat embryos. The resulting mutation is an 11-bp deletion in exon 2. PhysGen Knockouts mutant Extinct Cyp4a3em3Mcwi 5687737 5 135876140 135893753 1 - by flanking markers 5 138258628 138274813 1 - by flanking markers 5 134468666 134484851 1 - by flanking markers 5 129097571 129115488 1 - by flanking markers RRID:RGD_6484579 6484580 SS-Ldlrem2Mcwi This strain was produced by injecting ZFNs targeting the sequence TGCATCCCCAGCCTGTGGgcctgcGACGGGGACCGGGAC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 123-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Extinct (as of 2017-01-26) Ldlrem2Mcwi 5144094 8 20824040 20846920 1 - by flanking markers 8 22804325 22827199 1 - by flanking markers 8 22750425 22773305 1 - by flanking markers 8 20270020 20292981 1 - by flanking markers RRID:RGD_6484580 6484581 SS-Resp18em2Mcwi This strain was produced by injecting ZFNS targeting the sequence CTCAGCAGACTCCATCCCCagtatcCATGCCGGAAGGAGGGGAA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Resp18em2Mcwi 5687705 9 74551809 74558151 1 - by flanking markers 9 82240055 82246695 1 - by flanking markers 9 82470794 82477136 1 - by flanking markers 9 76765179 76771824 1 - by flanking markers RRID:RGD_6484581 6484583 SS-Nr2f2em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CCTTCTTCCCTGACCTGCagatcACGGACCAGGTGGCC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 15-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Nr2f2em1Mcwi 5687721 1 125280974 125286929 1 - by flanking markers 1 132486697 132499845 1 - by flanking markers 1 131447671 131465749 1 - by flanking markers 1 124008282 124022521 1 - by flanking markers RRID:RGD_6484583 6484584 SS-Adipoqem2Mcwi This strain was produced by injecting ZFNs targeting the sequence CAGGCATCCCAGGATATCctggtcACAATGGGATACCGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 4-bp frameshift deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-13) Adipoqem2Mcwi 5687716 11 79908291 79911065 1 - by flanking markers 11 84363940 84382663 1 - by flanking markers 11 81330845 81344488 1 - by flanking markers 11 77721912 77735644 1 - by flanking markers RRID:RGD_6484584 6484585 SS-Slc7a9em2Mcwi This strain was produced by injecting ZFNs targeting the sequence ATCGTCGCCATCATCATCatcagcGGACTGGTCCTCCTG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 6. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Slc7a9em2Mcwi 5687701 1 87976440 87999102 1 - by flanking markers 1 92836837 92865759 1 - by flanking markers 1 91709034 91738492 1 - by flanking markers 1 88109517 88132653 1 - by flanking markers RRID:RGD_6484585 6484711 SS-Atp2b1em2Mcwi This strain was produced by injecting ZFNs targeting the sequence TACCTTCTGGGTTCAgaagagGCCGTGGCTTGCTGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 117-bp deletion in intron 8 and exon 9. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Atp2b1em2Mcwi 6484707 7 36493661 36600280 1 - by flanking markers 7 41153926 41262537 1 - by flanking markers 7 41114606 41223138 1 - by flanking markers 7 33735595 33845226 1 - by flanking markers RRID:RGD_6484711 6484712 SS-Lpin1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CCCATCCACTGGTTCtctgggGAAGAAGAGAAGGAAAAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 4-bp deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Lpin1em1Mcwi 6484709 6 40253664 40297195 1 - by flanking markers 6 51532422 51638090 1 - by flanking markers 6 41796214 41905149 1 - by flanking markers 6 39309198 39417034 1 - by flanking markers RRID:RGD_6484712 6484713 SS-Cubnem1Mcwi This strain was produced by injecting ZFNs targeting the sequence CGGGAGTACCTTCAGATTcatgatGGAGACTCCTCAGCG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp deletion in exon 14. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Cubnem1Mcwi 6484705 17 87545893 87772079 1 - by flanking markers 17 82205509 82425565 1 - by flanking markers 17 80584921 80807181 1 - by flanking markers 17 76385046 76593133 1 - by flanking markers RRID:RGD_6484713 6484714 SS-Lssem2Mcwi This strain was produced by injecting ZFNs targeting the sequence CCCATCCACTGGTTCtctgggGAAGAAGAGAAGGAAAAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a net 12-bp deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Lssem2Mcwi 6484706 20 12507575 12534612 1 - by flanking markers 20 15000298 15338473 1 - by flanking markers 20 12844522 12870474 1 - by flanking markers 20 12091138 12118858 1 - by flanking markers RRID:RGD_6484714 6484715 SS-Adora2bem2Mcwi This strain was produced by injecting ZFNs targeting the sequence AACTACTTTCTGGTGTccctgGCGACGGCGGACGTGGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 162-bp deletion in exon 1 PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Adora2bem2Mcwi 5687698 10 48421592 48437967 1 - by flanking markers 10 48358068 48374871 1 - by flanking markers 10 48569563 48586366 1 - by flanking markers 10 46940394 46956772 1 - by flanking markers RRID:RGD_6484715 6484716 SS-Bcat1em2Mcwi This strain was produced by injecting ZFNs targeting the sequence CAGTCTGTACATCCGCCCCacattCATCGGGATTGAGGTA into SS/JrHsdMcwi rat embryos. The resulting mutation is 15-bp deletion in exon 5 PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Bcat1em2Mcwi 6484708 4 182641517 182692917 1 - by flanking markers 4 243444839 243491574 1 - by flanking markers 4 179259305 179340021 1 - by flanking markers 4 177964834 178046573 1 - by flanking markers RRID:RGD_6484716 6484717 SS-Cacna1hem2Mcwi This strain was produced by injecting ZFNs targeting the sequence CCGACCCACAGTGTCtgggagATCGTGGGGCAGGCAGAC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp deletion in exon 11. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Cacna1hem2Mcwi 6484703 10 14621372 14679051 1 - by flanking markers 10 14547456 14605627 1 - by flanking markers 10 14730932 14789201 1 - by flanking markers 10 14390104 14448204 1 - by flanking markers RRID:RGD_6484717 6484718 SS-Aceem2Mcwi This strain was produced by injecting ZFNs targeting the sequence GAAACCCAACCTCGATGTCaccagtACAATGGTACAGAAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp deletion in exon 6. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2017-01-13) Aceem2Mcwi 6484704 10 95361338 95381455 1 - by flanking markers 10 93922062 93965127 1 - by flanking markers 10 94170766 94213831 1 - by flanking markers 10 90910316 90930437 1 - by flanking markers RRID:RGD_6484718 6484719 SS-Leprem2Mcwi This strain was produced by injecting ZFNs targeting the sequence AGCATCGTACTGCCCacaatgGGACATGGTCACAAG into SS/JrHsdMcwi rat embryos. The resulting mutation was a 16-bp deletion in exon 11, predicted nonsense stop codon 30. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Leprem2Mcwi 6484701 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RGD_6484719 6484720 SS-Lepem5Mcwi This strain was produced by injecting ZFNs targeting the sequence CTGTGCCTATCCacaaaGTCCAGGATGACACC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Lepem5Mcwi 6484700 4 55943837 55945938 1 - by flanking markers 4 56085079 56099209 1 - by flanking markers 4 56337695 56351818 1 - by flanking markers 4 57661127 57675262 1 - by flanking markers RRID:RGD_6484720 6484721 SS-Aceem1Mcwi This strain was produced by injecting ZFNs targeting the sequence GAAACCCAACCTCGATGTCaccagtACAATGGTACAGAAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion in exon 6. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2018-11-12) Aceem1Mcwi 6484702 10 95361338 95381455 1 - by flanking markers 10 93922062 93965127 1 - by flanking markers 10 94170766 94213831 1 - by flanking markers 10 90910316 90930437 1 - by flanking markers RRID:RGD_6484721 6766770 BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi This congenic strain was developed by cyclic cross-intercross breeding using diabetic prone and diabetic resistant BB rats. (DP x DR)F1 x DR cross intercross breeding was used to generate F2 lymphopenic rats. These were then genotyped for both the flanking markers of the Gimap5 gene; maintained at Medical College of Wisconsin Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 4 75732943 75733127 1 - by flanking markers 4 141978848 141979031 1 - by flanking markers 4 77307388 79562753 1 - by flanking markers 4 76647384 78886189 1 - by flanking markers RRID:RGD_6766770 6893382 BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi-Il1r1em3Mcwi This strain was produced by injecting ZFNs targeting the sequence AGCTTCATACAGCGGCtccatgTTGCAGGGGATGGAAGTC into BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi rat embryos. The resulting mutation is a 1-bp insertion in exon 5. PhysGen Knockouts mutant Cryorecovery (as of 2017-01-26) Il1r1em3Mcwi 6893378 9 39434910 39473552 1 - by flanking markers 9 46647422 46723241 1 - by flanking markers 9 46962291 47038139 1 - by flanking markers 9 42504917 42580958 1 - by flanking markers RRID:RGD_6893382 6893383 SS-Fynem6Mcwi This strain was produced by injecting ZFNs targeting the sequence TCCATCCCGAACTACAACaacttcCACGCAGCCGGGGGCCAG into SS/JrHsdMcwi rat embryos. The resulting mutation is an 8-bp deletion in exon 4. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Fynem6Mcwi 6893380 20 43501853 43695567 1 - by flanking markers 20 46160734 46353456 1 - by flanking markers 20 44436354 44630316 1 - by flanking markers 20 42767733 42960903 1 - by flanking markers RRID:RGD_6893383 6893384 SS-Kcnj11em9Mcwi This strain was produced by injecting ZFNs targeting the sequence CTACAGAGCCCAGGTAccgtacTCGGGAGAGGAGGGC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Kcnj11em9Mcwi 6893381 1 96614960 96617993 1 - by flanking markers 1 103186859 103190535 1 - by flanking markers 1 102103093 102107134 1 - by flanking markers 1 96591048 96594574 1 - by flanking markers RRID:RGD_6893384 6893385 SS-Kcnj11em5Mcwi This strain was produced by injecting ZFNs targeting the sequence CTACAGAGCCCAGGTAccgtacTCGGGAGAGGAGGGC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Kcnj11em5Mcwi 6893379 1 96614960 96617993 1 - by flanking markers 1 103186859 103190535 1 - by flanking markers 1 102103093 102107134 1 - by flanking markers 1 96591048 96594574 1 - by flanking markers RRID:RGD_6893385 6893429 SS-Nos3em8Mcwi This strain was produced by injecting ZFNs targeting the sequence GACTTCATCAATCAGTACtataaCTCGATCAAAAGGTGGGT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 109-bp deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Nos3em8Mcwi 6893421 4 6158847 6179441 1 - by flanking markers 4 7333272 7353767 1 - by flanking markers 4 7321908 7342404 1 - by flanking markers 4 10793834 10814170 1 - by flanking markers RRID:RGD_6893429 6893430 SS-Nat8em4Mcwi This strain was produced by injecting ZFNs targeting the sequence CACATCCGCCAGTTCCAGgagaggGACTATGAACAGGTC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Nat8em4Mcwi 6893413 4 120001277 120002055 1 - by flanking markers 4 182101688 182103119 1 - by flanking markers 4 117525963 117527443 1 - by flanking markers 4 118279521 118284671 1 - by flanking markers RRID:RGD_6893430 6893431 SS-Nos3em13Mcwi This strain was produced by injecting ZFNs targeting the sequence GACTTCATCAATCAGTACtataaCTCGATCAAAAGGTGGGT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 165-bp deletion including part of exon 3, intron 3, and part of exon 4 PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2017-01-26) Nos3em13Mcwi 6893422 4 6158847 6179441 1 - by flanking markers 4 7333272 7353767 1 - by flanking markers 4 7321908 7342404 1 - by flanking markers 4 10793834 10814170 1 - by flanking markers RRID:RGD_6893431 6893432 SS-Hvcn1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CACACCCAGGCCATCCCTGgacttCAGGAGCCGGCTAAGGAA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp deletion in exon 5. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Hvcn1em1Mcwi 6893410 12 35536954 35556666 1 - by flanking markers 12 41702567 41731349 1 - by flanking markers 12 39822814 39851093 1 - by flanking markers 12 34341673 34370010 1 - by flanking markers RRID:RGD_6893432 6893433 SS-Nos3em2Mcwi This strain was produced by injecting ZFNs targeting the sequence GACTTCATCAATCAGTACtataaCTCGATCAAAAGGTGGGT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Nos3em2Mcwi 6893418 4 6158847 6179441 1 - by flanking markers 4 7333272 7353767 1 - by flanking markers 4 7321908 7342404 1 - by flanking markers 4 10793834 10814170 1 - by flanking markers RRID:RGD_6893433 6893434 SS-Kcnj16em1Mcwi-/- This strain was produced by injecting ZFNs targeting the sequence AGCTGCATCATAAACACCttcatcATTGGGGCAGCCTTGGCA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 18-bp deletion in exon 1. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2017-01-26) Kcnj16em1Mcwi 6893423 10 100514180 100515949 1 - by flanking markers 10 99027026 99087674 1 - by flanking markers 10 99330894 99391551 1 - by flanking markers 10 95990009 96021356 1 - by flanking markers RRID:RGD_6893434 6893435 SS-Tfdp2em6Mcwi This strain was produced by injecting ZFNs targeting the sequence GTCTGAGTTTACcaatgcGAGTAACCATCTGGCAGCT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp deletion in exon 6. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Tfdp2em6Mcwi 6893417 8 101256112 101392512 1 - by flanking markers 8 103489105 103629520 1 - by flanking markers 8 104040795 104181228 1 - by flanking markers 8 96760459 96901466 1 - by flanking markers RRID:RGD_6893435 6893436 SS-Kcnmb1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence AGCTGCATCATAAACACCttcatcATTGGGGCAGCCTTGGCA into SS/JrHsdMcwi rat embryos. The resulting allele is a net 4-bp deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Kcnmb1em1Mcwi 6893415 10 18904902 18912604 1 - by flanking markers 10 18790595 18800957 1 - by flanking markers 10 18910586 18922856 1 - by flanking markers 10 18557510 18614824 1 - by flanking markers RRID:RGD_6893436 6893437 BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi-Il1r1em1Mcwi This strain was produced by injecting ZFNs targeting the sequence AGCTTCATACAGCGGCtccatgTTGCAGGGGATGGAAGTC into BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi rat embryos. The resulting mutation is a 13-bp deletion in exon 5. PhysGen Knockouts mutant Extinct Il1r1em1Mcwi 6893425 9 39434910 39473552 1 - by flanking markers 9 46647422 46723241 1 - by flanking markers 9 46962291 47038139 1 - by flanking markers 9 42504917 42580958 1 - by flanking markers RRID:RGD_6893437 6893438 SS-Fgf1em2Mcwi This strain was produced by injecting ZFNs targeting the sequence TTCCAGTTCAGCTGCAGCtcagtGCGGAAAGCGCGGGCGAA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Fgf1em2Mcwi 6893412 18 31785480 31806452 1 - by flanking markers 18 31951411 32037426 1 - by flanking markers 18 32273830 32359831 1 - by flanking markers 18 30686555 30772667 1 - by flanking markers RRID:RGD_6893438 6893439 SS-Hvcn1em2Mcwi-/- This strain was produced by injecting ZFNs targeting the sequence CACACCCAGGCCATCCCTGgacttCAGGAGCCGGCTAAGGAA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp deletion in exon 5. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Hvcn1em2Mcwi 6893419 12 35536954 35556666 1 - by flanking markers 12 41702567 41731349 1 - by flanking markers 12 39822814 39851093 1 - by flanking markers 12 34341673 34370010 1 - by flanking markers RRID:RGD_6893439 6893440 SS-Fynem1Mcwi This strain was produced by injecting ZFNs targeting the sequence TCCATCCCGAACTACAACaacttcCACGCAGCCGGGGGCCAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion in exon 4. PhysGen Knockouts mutant Extinct Fynem1Mcwi 6893411 20 43501853 43695567 1 - by flanking markers 20 46160734 46353456 1 - by flanking markers 20 44436354 44630316 1 - by flanking markers 20 42767733 42960903 1 - by flanking markers RRID:RGD_6893440 6893441 SS-Grm7em2Mcwi This strain was produced by injecting ZFNs targeting the sequence ATCCGCCATGTTAACTTCaatggTAAGACTCCAATGTC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Grm7em2Mcwi 6893416 4 146952340 147270225 1 - by flanking markers 4 205768625 206680107 1 - by flanking markers 4 142452616 143368460 1 - by flanking markers 4 143730862 144613230 1 - by flanking markers RRID:RGD_6893441 6893442 SS-Ppargem1Mcwi This strain was produced by injecting ZFNs targeting the sequence TGCCATTCTGGCCCAccaactTCGGAATCAGCTCTG into SS/JrHsdMcwi rat embryos. The resulting mutation is a a 133-bp deletion of (RGSC 5.0/rn5): chr4:210,640,676-210,640,808, including part of intron 1 and exon 2 of isoform NM_013124.3 PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ppargem1Mcwi 6893424 4 151492220 151617331 1 - by flanking markers 4 210562928 210688585 1 - by flanking markers 4 147274055 147399383 1 - by flanking markers 4 148423102 148548471 1 - by flanking markers RRID:RGD_6893442 6893443 BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi-Il1r1em2Mcwi This strain was produced by injecting ZFNs targeting the sequence AGCTTCATACAGCGGCtccatgTTGCAGGGGATGGAAGTC into BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi rat embryos. The resulting mutation is a 7-bp deletin in exon 5. PhysGen Knockouts mutant Extinct Il1r1em2Mcwi 6893414 9 39434910 39473552 1 - by flanking markers 9 46647422 46723241 1 - by flanking markers 9 46962291 47038139 1 - by flanking markers 9 42504917 42580958 1 - by flanking markers RRID:RGD_6893443 6893444 SS-Kcnmb1em3Mcwi This strain was produced by injecting ZFNs targeting the sequence AGCTGCATCATAAACACCttcatcATTGGGGCAGCCTTGGCA into SS/JrHsdMcwi rat embryos. The resulting allele is a 21-bp deletion in exon 2 and intron 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Kcnmb1em3Mcwi 6893420 10 18904902 18912604 1 - by flanking markers 10 18790595 18800957 1 - by flanking markers 10 18910586 18922856 1 - by flanking markers 10 18557510 18614824 1 - by flanking markers RRID:RGD_6893444 6893530 BBDR.LA-(D5Rat98-D5Rat233)/Rhw Koletsky rat leptin receptor mutant (lepr) from the LA/N-cp was introgressed into the BBDR/Rhw rats by marker-assisted breeding. This was initiated in 2001 by Dr. Hansen and completed in 2007 at the University of Washington, Seattle. R. H. William Laboratory, University of Washington, Seattle, Washington congenic Unknown 5 100017060 124932061 1 - by flanking markers 5 103451053 127341295 1 - by flanking markers 5 99421434 123480464 1 - by flanking markers 5 95774194 118714492 1 - by flanking markers RRID:RGD_6893530 6893535 BBDR.LA-(D5Rat98-D5Rat233), BBDP-(D4Mit6-D4Mit7)/Rhw Heterozygous BBDR.LA-(D5Rat98-D5Rat233)/Rhw (DR.lepr) were crossed with homozygous BBDR.BBDP-(-(D4Mit6-D4Mit7)/Rhw (DR.Gimap5), to geenrate teh double congenic rats that had mutations for Gimap5 and lepr genes. R. H. William Laboratory, University of Washington, Seattle, Washington congenic Unknown RRID:RGD_6893535 6893551 DA.PVG.1AV1-(D1Rat32-D1Rat51)/Kini DA/Kini females were bred to PVG.1AV1/Kini males and male offspring selected for PVG alleles within the fragment. To ensure that mitochondrial DNA was inherited from the DA/Kini strain, female rats were from the DA/Kini strain throughout the breeding program. Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 1 112148733 159782631 1 - by flanking markers 1 173583273 202649821 1 - by flanking markers 1 167394665 195598217 1 - by flanking markers 1 156677124 156677310 1 - by flanking markers RRID:RGD_6893551 6893554 DA.PVG.1AV1-(D1Rat193-D1Rat68)/Kini DA/Kini females were bred to PVG.1AV1/Kini males and male offspring selected for PVG alleles within the fragment. To ensure that mitochondrial DNA was inherited from the DA/Kini strain, female rats were from the DA/Kini strain throughout the breeding program. Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 1 183163129 193070197 1 - by flanking markers 1 201022827 212591221 1 - by flanking markers 1 193968438 205603226 1 - by flanking markers 1 178810256 188377506 1 - by flanking markers RRID:RGD_6893554 6893599 SS-Pdcem3Mcwi This strain was produced by injecting ZFNs targeting the sequence CACCACCATCGTGGTtaacaTTTACGAGGATGGTGTCAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a net 47-bp deletion in exon 5. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Pdcem3Mcwi 5687712 13 64622473 64636031 1 - by flanking markers 13 72510251 72523421 1 - by flanking markers 13 67545430 67558600 1 - by flanking markers 13 62297281 62371754 1 - by flanking markers RRID:RGD_6893599 6893600 SS-Abcb1bem2Mcwi This strain was produced by injecting ZFNs targeting the sequence GAAAGCTGCCCACCTCATGgatgtgGCCGGAAACAAGGTGGGA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 98-bp frameshift deletion in exon 4. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-07-24) Abcb1bem2Mcwi 6893598 4 21829489 21912239 1 - by flanking markers 4 22161597 22244735 1 - by flanking markers 4 22225123 22307577 1 - by flanking markers 4 25242761 25325194 1 - by flanking markers RRID:RGD_6893600 6902893 BB.SHR-(Acsm3-Igf2)/K Congenics extablished as speed-congenics by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats Dept. of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany congenic Unknown Igf2|Acsm3 2870|62086 1 178054386 202915231 1 - by flanking markers 1 196449042 222733868 1 - by flanking markers 1 189514504 215839081 1 - by flanking markers 1 174133260 197831802 1 - by flanking markers RRID:RGD_6902893 6903879 SS/NEisSlc 1962: Dr. L. K. Dahl found the mutant rat from SD at NIH; 1989: Moved to Eisai (Eisai Co., Ltd.); 1991: Moved to BMR Institute for breeding; 1994: Started selling by SLC, Shizuoka, Japan inbred Unknown RRID:RGD_6903879 6903881 SR/NEisSlc 1962: Dr. L. K. Dahl found the mutant rat from SD at NIH; 1989: Moved to Eisai (Eisai Co., Ltd.); 1991: Moved to BMR Institute for breeding; 1994: Started selling by SLC, Shizuoka, Japan inbred Unknown RRID:RGD_6903881 6903902 WF.COP-(D2Uwm14-D2Uwm13)/Uwm A segment of chromosome 2 was transferred from COP into the WF background. University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 2 10539188 11957973 1 - by flanking markers 2 10116941 11387756 1 - by flanking markers 2 10246312 11522696 1 - by flanking markers 2 12654100 13840758 1 - by flanking markers RRID:RGD_6903902 6903904 WF.COP-(D2Uwm17-D2Rat16)/Uwm A segment of chromosome 2 was transferred from COP into the WF background. University of Wisconsin, Madison, Wisconsin, USA congenic Unknown 2 32051319 43376636 1 - by flanking markers 2 50381686 62691053 1 - by flanking markers 2 31224612 43643900 1 - by flanking markers 2 32373770 43665178 1 - by flanking markers RRID:RGD_6903904 6903912 SS.SHR-(D9Mco72-D9Rat89)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Mco72-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 44842118 72258219 1 - by flanking markers 9 52352690 80172715 1 - by flanking markers 9 52686874 80400631 1 - by flanking markers 9 47902208 74701891 1 - by flanking markers RRID:RGD_6903912 6903914 SS.SHR-(D9Mco72-D9Rat55)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Mco72-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 44842118 69875226 1 - by flanking markers 9 52352690 77741892 1 - by flanking markers 9 52686874 77966876 1 - by flanking markers 9 47902208 47902417 1 - by flanking markers RRID:RGD_6903914 6903917 SS.SHR-(D9Mco72-D9Mco109)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Mco72-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 44842118 44842324 1 - by flanking markers 9 52352690 52352896 1 - by flanking markers 9 52686874 72470724 1 - by flanking markers 9 47902208 67020125 1 - by flanking markers RRID:RGD_6903917 6903920 SS.SHR-(D9Mco72-D9Uia4)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Mco72-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 44842118 59247627 1 - by flanking markers 9 52352690 67265755 1 - by flanking markers 9 52686874 67451944 1 - by flanking markers 9 47902208 62072556 1 - by flanking markers RRID:RGD_6903920 6903922 SS.SHR-(D9Mco72-D9Mco106)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Mco72-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 44842118 44842324 1 - by flanking markers 9 52352690 52352896 1 - by flanking markers 9 52686874 58156770 1 - by flanking markers 9 47902208 53185096 1 - by flanking markers RRID:RGD_6903922 6903925 SS.SHR-(D9Mco72-D9Mco105)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Mco72-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 44842118 44842324 1 - by flanking markers 9 52352690 52352896 1 - by flanking markers 9 52686874 57216771 1 - by flanking markers 9 47902208 52283252 1 - by flanking markers RRID:RGD_6903925 6903928 SS.SHR-(D9Rat7-D9Got111)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Rat7-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 77172934 89249893 1 - by flanking markers 9 83453664 96967940 1 - by flanking markers 9 97276144 97276310 1 - by flanking markers 9 90719946 90720113 1 - by flanking markers RRID:RGD_6903928 6903932 SS.SHR-(D9Rat7-D9Rat52)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Rat7-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 77172934 81205197 1 - by flanking markers 9 83453664 87395775 1 - by flanking markers RRID:RGD_6903932 6903934 SS.SHR-(D9Rat7-D9Mco91)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Rat7-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 77172934 78634594 1 - by flanking markers 9 83453664 84866878 1 - by flanking markers 9 85112340 85112539 1 - by flanking markers 9 80676321 80676524 1 - by flanking markers RRID:RGD_6903934 6903936 SS.SHR-(D9Rat7-D9Rat84)/Mco This is a congenic substrain developed by crossing SS.SHR-(D9Rat7-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio congenic Unknown 9 77172934 83316504 1 - by flanking markers 9 83453664 91313982 1 - by flanking markers 9 91579562 91579769 1 - by flanking markers 9 85193982 85194188 1 - by flanking markers RRID:RGD_6903936 6907047 WF.WKY-(D5Uwm63-D5Uwm60)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Wox7-D5Uwm37). University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 57848236 76159022 1 - by flanking markers 5 61271852 79426001 1 - by flanking markers 5 56733010 75274687 1 - by flanking markers 5 55564549 72943679 1 - by flanking markers RRID:RGD_6907047 6907054 WF.WKY-(D5Uwm67-D5Uwm98)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 79919505 79919776 1 - by flanking markers 5 82897463 82897734 1 - by flanking markers 5 78777540 82587133 1 - by flanking markers 5 76369776 80145576 1 - by flanking markers RRID:RGD_6907054 6907057 WF.WKY-(D5Uwm76-D5Uwm61)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 84434303 84434576 1 - by flanking markers 5 87362775 87363048 1 - by flanking markers 5 83268986 83269259 1 - by flanking markers 5 80813116 80813390 1 - by flanking markers RRID:RGD_6907057 6907059 WF.WKY-(D5Uwm76-D5Uwm98)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 82586913 82587133 1 - by flanking markers 5 80145359 80145576 1 - by flanking markers RRID:RGD_6907059 6907061 WF.WKY-(D5Uwm67-D5Uwm78)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 79919505 79919776 1 - by flanking markers 5 82897463 82897734 1 - by flanking markers 5 78777540 79954846 1 - by flanking markers 5 76369776 77541025 1 - by flanking markers RRID:RGD_6907061 6907063 WF.WKY-(D5Uwm76-D5Got18)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 82406661 82406827 1 - by flanking markers 5 85556660 85556825 1 - by flanking markers 5 81457871 81458036 1 - by flanking markers 5 79031392 79031558 1 - by flanking markers RRID:RGD_6907063 6907076 WF.WKY-(D5Uwm78-D5Uwm98)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 82406661 82406827 1 - by flanking markers 5 85556660 85556825 1 - by flanking markers 5 79954586 81458036 1 - by flanking markers 5 77540762 79031558 1 - by flanking markers RRID:RGD_6907076 6907078 WF.WKY-(D5Uwm95-D5Uwm98)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 82406661 82406827 1 - by flanking markers 5 85556660 85556825 1 - by flanking markers 5 80975875 81458036 1 - by flanking markers 5 78554205 79031558 1 - by flanking markers RRID:RGD_6907078 6907080 WF.WKY-(D5Uwm67-D5Uwm81)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 79919505 79919776 1 - by flanking markers 5 82897463 82897734 1 - by flanking markers 5 78777540 80126657 1 - by flanking markers 5 76369776 77714928 1 - by flanking markers RRID:RGD_6907080 6907084 WF.WKY-(D5Uwm76-D5Uwm92)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 80451098 80451339 1 - by flanking markers 5 78038840 78039084 1 - by flanking markers RRID:RGD_6907084 6907087 WF.WKY-(D5Uwm78-D5Uwm84)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 79954586 80203685 1 - by flanking markers 5 77540762 77791604 1 - by flanking markers RRID:RGD_6907087 6907090 WF.WKY-(D5Uwm78-D5Uwm93)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 79954586 80518802 1 - by flanking markers 5 77540762 78102136 1 - by flanking markers RRID:RGD_6907090 6907092 WF.WKY-(D5Uwm88-D5Uwm92)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 80401019 80451339 1 - by flanking markers 5 77988604 78039084 1 - by flanking markers RRID:RGD_6907092 6907094 WF.WKY-(D5Uwm87-D5Uwm92)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 80372955 80451339 1 - by flanking markers 5 77960535 78039084 1 - by flanking markers RRID:RGD_6907094 6907096 WF.WKY-(D5Uwm85-D5Uwm92)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 80229223 80451339 1 - by flanking markers 5 77816155 78039084 1 - by flanking markers RRID:RGD_6907096 6907098 WF.WKY-(D5Uwm82-D5Uwm92)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 80154593 80451339 1 - by flanking markers 5 77743239 78039084 1 - by flanking markers RRID:RGD_6907098 6907100 WF.WKY-(D5Uwm82-D5Uwm91)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 80154593 80431178 1 - by flanking markers 5 77743239 78018921 1 - by flanking markers RRID:RGD_6907100 6907104 WF.WKY-(D5Uwm77-D5Uwm91)/Uwm A sub congenic strain derived from the progenitor strain WF.WKY-(D5Uwm68-D5Mit4)/Uwm. University of Wisconsin School of Medicine, Madison, Wisconsin congenic Unknown 5 79935684 80431178 1 - by flanking markers 5 77521860 78018921 1 - by flanking markers RRID:RGD_6907104 6907436 SS.BN-(D13Hmgc41-D13Hmgc23)/Mcwi These were generated by crossing SS/JrHsdMcwi with SS-Chr 13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 45282442 47299604 1 - by flanking markers 13 54236862 56238470 1 - by flanking markers 13 49168131 51182122 1 - by flanking markers 13 43830075 43830298 1 - by flanking markers RRID:RGD_6907436 6907438 SS.BN-(D13Rat77-D13Rat105)/Mcwi These were generated by crossing SS/JrHsdMcwi with SS-Chr 13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 45592985 63175600 1 - by flanking markers 13 54552997 71047437 1 - by flanking markers 13 49478067 66075827 1 - by flanking markers 13 44139595 60933518 1 - by flanking markers RRID:RGD_6907438 6907445 SS.BN-(D13Rat124-D13Rat101)/Mcwi These were generated by crossing SS/JrHsdMcwi with SS-Chr 13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 46721037 49428577 1 - by flanking markers 13 55662705 58314767 1 - by flanking markers 13 50609228 53264877 1 - by flanking markers 13 45228358 47841255 1 - by flanking markers RRID:RGD_6907445 7204133 LEW-Rag1em1Ztm This strain was produced by injecting ZFNs into LEW/Ztm rat embryos. The resulting mutation is a 4-bp frameshift deletion in exon 2. Zentrales Tierlaboratorium, Medizinische Hochschule Hannover, Germany mutant Unknown Rag1em1Ztm 7204132 3 86780782 86791878 1 - by flanking markers 3 97866048 97877145 1 - by flanking markers 3 91206394 91217491 1 - by flanking markers 3 87917061 87928158 1 - by flanking markers RRID:RGD_7204133 7204136 SD-Rag1em1Ang This strain was produced by injecting ZFNs into Sprague-Dawley rat embryos. The resulting mutation is a 5-bp frameshift deletion in the Rag1 gene that predicts a protein with a normal sequence up to aa 245, followed by 5 aa from the insertions and mutations, followed by a stop codon in position 751. Institut National de la Sante et de la Recherche Medicale (INSERM) mutant Unknown Rag1em1Ang 7204135 3 86780782 86791878 1 - by flanking markers 3 97866048 97877145 1 - by flanking markers 3 91206394 91217491 1 - by flanking markers 3 87917061 87928158 1 - by flanking markers RRID:RGD_7204136 7207880 LEW.WKY-(D13Arb15-D13Rat58)/Tja Segment of interest from chr 13 of WKY/NCrl was introgressed into LEW/SsNHsd Imperial College, London, UK congenic Unknown 13 71116479 96441728 1 - by flanking markers 13 78673431 103987907 1 - by flanking markers 13 73748382 98985851 1 - by flanking markers 13 68269576 92436175 1 - by flanking markers RRID:RGD_7207880 7240510 DA.PVG.1AV1-(D4Rat113-D4Kiru96)/Kiru congenic strain derived by marker-assisted transfer of the desired region from PVG.1AV1/Kini onto the genetic background of DA/ZtmKini Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University, Stockholm, Sweden congenic Unknown 4 157006984 157007337 1 - by flanking markers 4 220242234 220242357 1 - by flanking markers 4 153152949 155869653 1 - by flanking markers 4 153826368 156260744 1 - by flanking markers RRID:RGD_7240510 7240512 DA.PVG.1AV1-(D4Rat113-D4Kiru80)/Kiru congenic strain derived by marker-assisted transfer of the desired region from PVG.1AV1/Kini onto the genetic background of DA/ZtmKini Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University, Stockholm, Sweden congenic Unknown 4 157006984 157007337 1 - by flanking markers 4 220242234 220242357 1 - by flanking markers 4 153152949 156629648 1 - by flanking markers 4 153826368 156956242 1 - by flanking markers RRID:RGD_7240512 7240513 DA.PVG.1AV1-(D4Kiru90-D4Kiru111)/Kiru congenic strain derived by marker-assisted transfer of the desired region from PVG.1AV1/Kini onto the genetic background of DA/ZtmKini Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University, Stockholm, Sweden congenic Unknown 4 155730927 157145363 1 - by flanking markers 4 156124880 157432020 1 - by flanking markers RRID:RGD_7240513 7240514 DA.PVG.1AV1-(D4Kiru12-D4Kiru55)/Kiru Congenic substrain derived by marker-assisted transfer of the desired region from DA.PVG.1AV1-(D4Kiru90-D4Kiru111)/Kiru onto the genetic background of DA/ZtmKini Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University, Stockholm, Sweden congenic Unknown 4 155929794 156347543 1 - by flanking markers 4 156207922 156684523 1 - by flanking markers RRID:RGD_7240514 7240521 DA.PVG.1AV1-(D4Kini3-D4Rat177)/Kini DA/ZtmKini females were mated with PVG.1AV1/Kini males; breeding pair from N5 generation were crossed for 2 generation to get the desired congenic strain Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden congenic Unknown 4 114073976 114074165 1 - by flanking markers 4 175324865 175325053 1 - by flanking markers 4 110635261 110635449 1 - by flanking markers 4 112478605 112478794 1 - by flanking markers RRID:RGD_7240521 7240522 DA.PVG.1AV1-(D4Kini3-D4Mgh14)/Kini DA/ZtmKini females were mated with PVG.1AV1/Kini males; breeding pair from N5 generation were crossed for 2 generation to get the desired congenic strain Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Viral encephalitis (HSE) 4 36592628 36592773 1 - by flanking markers 4 37534124 37534268 1 - by flanking markers 4 28161938 37685319 1 - by flanking markers 4 31021248 39505420 1 - by flanking markers RRID:RGD_7240522 7241047 LE-Lrrk1em1SageLrrk2em1Sage This strain was produced by crossing LE-Lrrk1em1Sage with LE-Lrrk2em1Sage Horizon Discovery mutant Cryopreserved Embryo (as of 2017-06-06) Lrrk1em1SageLrrk2em1Sage 7241043 7 130105902 130267747 1 - by flanking markers 7 132531591 132694226 1 - by flanking markers 7 132857311 133018549 1 - by flanking markers 7 122826712 122987711 1 - by flanking markers RRID:RGD_7241047 7241048 LE-Park7em1Sage This strain was produced by injecting ZFNs into Crl:LE rat embryos. The resulting mutation is a 9-bp deletion with 1-bp insertion in exon 5 Sigma Advanced Genetic Engineering Labs mutant Unknown Park7em1Sage 7241042 5 168050149 168061616 1 - by flanking markers 5 171559202 171582476 1 - by flanking markers 5 167982438 168004724 1 - by flanking markers 5 161353718 161376993 1 - by flanking markers RRID:RGD_7241048 7241049 LE-Pink1em1Sage-/- ZFN mutant founders were backcrossed with Crl:LE to get heterozygous offspring which were intercrossed and offspring maintained as homozygous. This allele was made by ZFN mutagenesis. The resulting mutation is a 26-bp frameshift deletion in exon 4 (ACTACTACCCAGAAGGCCTGGGCCAC). Horizon Discovery mutant Live Animals (as of 2017-05-08) Pink1em1Sage 7241046 5 157091181 157103293 1 - by flanking markers 5 160425715 160437827 1 - by flanking markers 5 156677146 156689258 1 - by flanking markers 5 150530523 150542635 1 - by flanking markers RRID:RGD_7241049 7241050 LE-Lrrk2em1Sage This strain was produced by injecting ZFNs into Crl:LE rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 30. Horizon Discovery mutant Live Animals (as of 2017-06-06) Lrrk2em1Sage 7241045 7 130105902 130267747 1 - by flanking markers 7 132531591 132694226 1 - by flanking markers 7 132857311 133018549 1 - by flanking markers 7 122826712 122987711 1 - by flanking markers RRID:RGD_7241050 7241051 LE-Lrrk1em1Sage This strain was produced by injecting ZFNs into Crl:LE rat embryos. The resulting mutation is a 19-bp frameshift deletion in exon 4. Horizon Discovery mutant Unknown Lrrk1em1Sage 7241044 1 120695657 120836324 1 - by flanking markers 1 128248473 128372456 1 - by flanking markers 1 127166866 127301053 1 - by flanking markers 1 119844360 119972885 1 - by flanking markers RRID:RGD_7241051 7241052 LE-Prknem1Sage-/- ZFN mutant founders were backcrossed with Crl:LE to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous. The resulting mutation is a 5-bp frameshift deletion in exon 4 (TCAGT). Horizon Discovery mutant Unknown Prknem1Sage 7241041 1 43151265 44374470 1 - by flanking markers 1 49684308 50875397 1 - by flanking markers 1 48880015 50069998 1 - by flanking markers 1 48688651 49882520 1 - by flanking markers RRID:RGD_7241052 7241053 LE-Lrrk1em1Sage-/-Lrrk2em1Sage-/- ZFN mutant founders were backcrossed with Crl:LE to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous Horizon Discovery mutant Unknown Lrrk1em1SageLrrk2em1Sage 7241043 7 130105902 130267747 1 - by flanking markers 7 132531591 132694226 1 - by flanking markers 7 132857311 133018549 1 - by flanking markers 7 122826712 122987711 1 - by flanking markers RRID:RGD_7241053 7241054 LE-Pink1em1Sage This strain was produced by injecting ZFNs into Crl:LE rat embryos. The resulting mutation is a 26-bp frameshift deletion in exon 4. Sigma Advanced Genetic Engineering Labs mutant Unknown Pink1em1Sage 7241046 5 157091181 157103293 1 - by flanking markers 5 160425715 160437827 1 - by flanking markers 5 156677146 156689258 1 - by flanking markers 5 150530523 150542635 1 - by flanking markers RRID:RGD_7241054 7241055 LE-Park7em1Sage-/- ZFN mutant founders were backcrossed with Crl:LE to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous. The resulting mutation is a 9-bp deletion with 1-bp insertion in exon 5 (TTGGTGAAGA). Horizon Discovery mutant Live Animals (as of 2017-05-08) Park7em1Sage 7241042 5 168050149 168061616 1 - by flanking markers 5 171559202 171582476 1 - by flanking markers 5 167982438 168004724 1 - by flanking markers 5 161353718 161376993 1 - by flanking markers RRID:RGD_7241055 7241056 LE-Lrrk2em1Sage-/- ZFN mutant founders were backcrossed with Crl:LE to get heterozygous offspring which were intercrossed and offsprings maintained as homozygous Sigma Advanced Genetic Engineering Labs mutant Live Animals (as of 2018-08-24) Lrrk2em1Sage 7241045 7 130105902 130267747 1 - by flanking markers 7 132531591 132694226 1 - by flanking markers 7 132857311 133018549 1 - by flanking markers 7 122826712 122987711 1 - by flanking markers RRID:RGD_7241056 7241057 LE-Lrrk1em1Sage-/- ZFN mutant founders carrying a 19-bp frameshift deletion in exon 4 were backcrossed with Crl:LE to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous. Horizon Discovery mutant Unknown Lrrk1em1Sage 7241044 1 120695657 120836324 1 - by flanking markers 1 128248473 128372456 1 - by flanking markers 1 127166866 127301053 1 - by flanking markers 1 119844360 119972885 1 - by flanking markers RRID:RGD_7241057 7241058 LE-Prknem1Sage This strain was produced by injecting ZFNs into Crl:LE rat embryos. The resulting mutation is a 5-bp frameshift deletion in exon 4. Sigma Advanced Genetic Engineering Labs mutant Unknown Prknem1Sage 7241041 1 43151265 44374470 1 - by flanking markers 1 49684308 50875397 1 - by flanking markers 1 48880015 50069998 1 - by flanking markers 1 48688651 49882520 1 - by flanking markers RRID:RGD_7241058 7241239 DA.BN-(D9Wox18-D9Rat20)/Kini DA/ZtmKini females were mated with BN/Rj males, speed congenic strategy was used to generate these congenics; when the donor genome outside of the congenic segment was removed, two heterozygous animals were intercrossed to produce homozygous rats Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 9 18347599 47129300 1 - by flanking markers 9 24554204 54685631 1 - by flanking markers 9 25692373 54978814 1 - by flanking markers 9 22071200 50062324 1 - by flanking markers RRID:RGD_7241239 7241240 DA.BN-(D9Mit6-D9Rat29)/Kini DA/ZtmKini females were mated with BN/Rj males, speed congenic strategy was used to generate these congenics; when the donor genome outside of the congenic segment was removed, two heterozygous animals were intercrossed to produce homozygous rats Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 9 1526763 22066432 1 - by flanking markers 9 28304251 28304379 1 - by flanking markers 9 29466970 29467098 1 - by flanking markers 9 25661188 25661317 1 - by flanking markers RRID:RGD_7241240 7241241 DA.BN-(D9Mit6-D9Got15)/Kini DA/ZtmKini females were mated with BN/Rj males, speed congenic strategy was used to generate these congenics; when the donor genome outside of the congenic segment was removed, two heterozygous animals were intercrossed to produce homozygous rats Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 9 1526763 6948180 1 - by flanking markers 9 12615141 12615255 1 - by flanking markers 9 13683965 13684079 1 - by flanking markers 9 11735861 11735976 1 - by flanking markers RRID:RGD_7241241 7241242 DA.BN-(D9Got8-D9Rat139)/Kini DA/ZtmKini females were mated with BN/Rj males, speed congenic strategy was used to generate these congenics; when the donor genome outside of the congenic segment was removed, two heterozygous animals were intercrossed to produce homozygous rats Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 9 2174611 3811711 1 - by flanking markers 9 2597055 37252772 1 - by flanking markers 9 2657610 3308009 1 - by flanking markers 9 4301731 5859822 1 - by flanking markers RRID:RGD_7241242 7241243 DA.BN-(D9Wox24-D9Rat20)/Kini DA/ZtmKini females were mated with BN/Rj males, speed congenic strategy was used to generate these congenics; when the donor genome outside of the congenic segment was removed, two heterozygous animals were intercrossed to produce homozygous rats Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 9 47129152 47129300 1 - by flanking markers 9 9858502 54685631 1 - by flanking markers 9 10869391 54978814 1 - by flanking markers 9 1024537 50062324 1 - by flanking markers RRID:RGD_7241243 7241244 DA.BN-(D9Wox24-D9Wox18)/Kini DA/ZtmKini females were mated with BN/Rj males, speed congenic strategy was used to generate these congenics; when the donor genome outside of the congenic segment was removed, two heterozygous animals were intercrossed to produce homozygous rats Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 9 18347599 18347796 1 - by flanking markers 9 9858502 24554401 1 - by flanking markers 9 10869391 25692570 1 - by flanking markers 9 1024537 22071398 1 - by flanking markers RRID:RGD_7241244 7241245 DA.BN-(D9Wox24-D9Rat139)/Kini DA/ZtmKini females were mated with BN/Rj males, speed congenic strategy was used to generate these congenics; when the donor genome outside of the congenic segment was removed, two heterozygous animals were intercrossed to produce homozygous rats Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 9 2174611 2174738 1 - by flanking markers 9 9858502 37252772 1 - by flanking markers 9 3307883 10869489 1 - by flanking markers 9 1024537 5859822 1 - by flanking markers RRID:RGD_7241245 7241246 DA.BN-(D9Wox24-D9Rat44)/Kini DA/ZtmKini females were mated with BN/Rj males, speed congenic strategy was used to generate these congenics; when the donor genome outside of the congenic segment was removed, two heterozygous animals were intercrossed to produce homozygous rats Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 9 2948882 2949051 1 - by flanking markers 9 2813697 9858600 1 - by flanking markers 9 2880977 10869489 1 - by flanking markers 9 1024537 5109995 1 - by flanking markers RRID:RGD_7241246 7241247 LEW.BN-(D9Got8-D9Got22)/Kini LEW/Rj females were mated with BN/Rj males, speed congenic strategy was used to generate these congenics; when the donor genome outside of the congenic segment was removed, two heterozygous animals were intercrossed to produce homozygous rats Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 9 3811425 12324010 1 - by flanking markers 9 2597055 17959093 1 - by flanking markers 9 2657610 19076070 1 - by flanking markers 9 4301731 16665381 1 - by flanking markers RRID:RGD_7241247 7241248 LEW.BN-(D9Wox24-D9Got22)/Kini LEW/Rj females were mated with BN/Rj males, speed congenic strategy was used to generate these congenics; when the donor genome outside of the congenic segment was removed, two heterozygous animals were intercrossed to produce homozygous rats Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden congenic Unknown 9 12323882 12324010 1 - by flanking markers 9 9858502 17959093 1 - by flanking markers 9 10869391 19076070 1 - by flanking markers 9 1024537 16665381 1 - by flanking markers RRID:RGD_7241248 7241265 SHR-Chr YWKY/Akr WKY/NHsd males were crosssed with SHR/NHsd females to get F1 animals, the hybrid animals were backcrossed with female SHR/NHsd to transfer the Y chromosome Universityof Akron breeding colonies, The University of Akron, Akron, Ohio consomic Unknown RRID:RGD_7241265 7241267 WKY-Chr YSHR/Akr SHR/NHsd males were crosssed with WKY/NHsd females to get F1 animals, the hybrid animals were backcrossed with female WKY/NHsd to transfer the Y chromosome University of Akron breeding colonies, The University of Akron, Akron, Ohio consomic Unknown RRID:RGD_7241267 7241271 SHR.BN-(D10Mit4-D10Wox11)/Cub Segment of chromosome 10 from BN.Lx/Cub was transferred to SHR/Ola after 9 backcrosses an intercross was done to obtain the desired congenic Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic congenic Unknown 10 36649906 53793117 1 - by flanking markers 10 36354729 53388667 1 - by flanking markers 10 36584373 53637634 1 - by flanking markers 10 35392267 51786432 1 - by flanking markers RRID:RGD_7241271 7241594 (SDxF344)F1-Rbm20m1Mlgw This mutation, a deletion in chromosome 1 between bp 260,070,892 and 260,166,363, was originally found in the offspring of Hsd:SD x Hsd:SD. The phenotype was an altered titin isoform expression in the offspring. The parent carrier was identified by crossing both the male and the female Hsd:SD with F344/NHsd. This mutation is maintained on Hsd:SD X F344/NHsd. University of Wisconsin, Madison mutant Cryopreserved Sperm (as of 2017-01-25) Rbm20m1Mlgw 7241593 1 259905545 260144190 1 - by flanking markers 1 281783646 282003053 1 - by flanking markers 1 274391932 274589816 1 - by flanking markers 1 252683760 252907465 1 - by flanking markers RRID:RGD_7241594 7241595 (SDxF344)F1xBN-Rbm20m1Mlgw+/+ Heterozygous offspring were intercrossed and maintained as wild type University of Wisconsin, Madison mutant Cryopreserved Sperm Rbm20m1Mlgw 7241593 1 259905545 260144190 1 - by flanking markers 1 281783646 282003053 1 - by flanking markers 1 274391932 274589816 1 - by flanking markers 1 252683760 252907465 1 - by flanking markers RRID:RGD_7241595 7241596 (SDxF344)F1-Rbm20m1Mlgw+/+ Heterozygous offsprings were intercrossed and maintained as wild type University of Wisconsin, Madison mutant Cryopreserved Sperm Rbm20m1Mlgw 7241593 1 259905545 260144190 1 - by flanking markers 1 281783646 282003053 1 - by flanking markers 1 274391932 274589816 1 - by flanking markers 1 252683760 252907465 1 - by flanking markers RRID:RGD_7241596 7241597 (SDxF344)F1xBN-Rbm20m1Mlgw This mutation, a deletion in chromosome 1 between bp 260,070,892 and 260,166,363, was originally found in the offspring of Hsd:SD x Hsd:SD. The phenotype was an altered titin isoform expression in the offspring. The parent carrier was identified by crossing both the male and the female Hsd:SD with F344/NHsd. This mutation is maintained on Hsd:SD X F344/NHsd. University of Wisconsin, Madison mutant Cryopreserved Sperm (as of 2017-01-25) Rbm20m1Mlgw 7241593 1 259905545 260144190 1 - by flanking markers 1 281783646 282003053 1 - by flanking markers 1 274391932 274589816 1 - by flanking markers 1 252683760 252907465 1 - by flanking markers RRID:RGD_7241597 7241794 SHR/Bbb This SHR colony is maintained at Max-Delbruck Center for Molecular Medicine, Germany Max-Delbruck Center for Molecular Medicine, Germany inbred Unknown RRID:RGD_7241794 7241811 BBDP.WF-(D8Rat73-D8Sunn1467)(D13Rat124-D13Mgh5)/Sunn a double congenic strain which has more than 38.74 Mb of chr 8 and more than 16.78 Mb of chr 13 of Wistar Furth introgressed into the gentic background of BBDP/WorSunn Department of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada congenic Unknown RRID:RGD_7241811 7243955 DA.F344-(D4Got44-D4Arb21)/Arb Congenic substrain derived from backcrossing DA.F344-(D4Got44-D4Arb4)/Arb (DA.F344(Cia3) with DA/BklArbN; after 10 backcrosses offsprings were intercrossed to ensure homozygosity The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown 4 63884916 104416123 1 - by flanking markers 4 63125453 163844250 1 - by flanking markers 4 63411811 99067102 1 - by flanking markers 4 65117277 103194936 1 - by flanking markers RRID:RGD_7243955 7243960 DA.F344-(D4Got44-D4Rat128)/Arb Congenic substrain derived from backcrossing DA.F344-(D4Got44-D4Arb4)/Arb (DA.F344(Cia3) with DA/BklArbN; after 10 backcrosses offsprings were intercrossed to ensure homozygosity The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown 4 63884916 79190364 1 - by flanking markers 4 63125453 145335458 1 - by flanking markers 4 63411811 80666496 1 - by flanking markers 4 65117277 79987019 1 - by flanking markers RRID:RGD_7243960 7243963 DA.F344-(D4Uia2-D4Wox21)/Arb Congenic substrain derived from backcrossing DA.F344-(D4Got44-D4Arb4)/Arb (DA.F344(Cia3) with DA/BklArbN; after 10 backcrosses offsprings were intercrossed to ensure homozygosity The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown 4 68131191 78039646 1 - by flanking markers 4 133170446 144249459 1 - by flanking markers 4 68379412 79575667 1 - by flanking markers 4 69364375 78882954 1 - by flanking markers RRID:RGD_7243963 7243965 DA.F344-(D4Arb21-D4Arb4)/Arb Congenic substrain derived from backcrossing DA.F344-(D4Got44-D4Arb4)/Arb (DA.F344(Cia3) with DA/BklArbN; after 10 backcrosses offsprings were intercrossed to ensure homozygosity The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown 4 104415843 154937227 1 - by flanking markers 4 163843971 216606455 1 - by flanking markers 4 99066823 150682594 1 - by flanking markers 4 103194656 151805662 1 - by flanking markers RRID:RGD_7243965 7243966 DA.F344-(D4Arb5-D4Arb4)/Arb Congenic substrain derived from backcrossing DA.F344-(D4Got44-D4Arb4)/Arb (DA.F344(Cia3) with DA/BklArbN; after 10 backcrosses offsprings were intercrossed to ensure homozygosity The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown 4 120436701 154937227 1 - by flanking markers 4 182615641 216606455 1 - by flanking markers 4 118044851 150682594 1 - by flanking markers 4 118699819 151805662 1 - by flanking markers RRID:RGD_7243966 7244374 FXLE/Stm Recombinant inbred strain derived from Le/Stm (from Ben May, Laboratory for Cancer Research, University of Chicago, Chicago IL) and F344/DuCrlj (from Charles River Japan) and then maintained by brother-sister mating. Saitama Cancer Center Research Institute, 818 Komuro Saitama, Japan advanced_intercross_line Unknown RRID:RGD_7244374 7244380 DA.F344(Cia3c)/Arb Congenic substrain derived from backcrossing DA.F344-(D4Got44-D4Arb4)/Arb (DA.F344(Cia3) with DA/BklArbN; after 10 backcrosses offsprings were intercrossed to ensure homozygosity The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown RRID:RGD_7244380 7244381 DA.F344(Cia3e)/Arb Congenic substrain derived from backcrossing DA.F344-(D4Got44-D4Arb4)/Arb (DA.F344(Cia3) with DA/BklArbN; after 10 backcrosses offsprings were intercrossed to ensure homozygosity The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland congenic Unknown RRID:RGD_7244381 7245481 SD-Tg(hsMt-LacZ)Reh presses LacZ under the transcriptional control of the mouse metallothionein regulatory sequences. Transgene expression in germ cells is constitutive; expression of the transgene can be induced in liver by zinc or cadmium. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-02-05) RRID:RRRC_00540 7245482 SD-Tg(ROSA26-EGFP)RehRrrc Strain carries a 1.8kb transgene consisting of the mouse ROSA26 regulatory sequences driving EGFP. FISH was used to localize the transgene insertion to Chromosome 11q11-q12, proximal to Grik1 and near Ncam2. The transgene is expressed exclusively in male and female germ cells throughtout development. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-02-05) RRID:RRRC_00541 7245488 SD-Tg(Chat-tTA) Rats express a mouse tetracycline-controlled transactivator (tTA) driven by the mouse choline acetyltransferase (Chat) promotor. When mated to a second transgenic strain (RRRC:00633) that carries a target gene (TDP43) under the regulation of a tetracycline response element (TRE), the expression of TDP43 in Chat-expressing motor neurons in the double transgenic rats can be induced by withdrawal of doxycycline. Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2019-02-05) RRID:RRRC_00632 7245494 SD-Tg(TRE-TARDBP-M337V) Strain carries a transgene expressing human TDP43 with the M337V mutation under control of a tTA-dependent promoter (TRE). When mated to a second transgenic strain (RRRC:632) that carries a tetracycline-controlled transactivator driven by the mouse choline acetyltransferase (Chat) promoter, the expression of mutant TDP43 in Chat-expressing motor neurons in the double transgenic rats can be induced by withdrawal of doxycycline. Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2019-02-05) TARDBP 1322081 RRID:RRRC_00633 7245521 SD-Tg(Th-SNCA*)3Ins the transgene overexpressing human mutated alpha-synuclein (A53T and A30P) under the control of rat tyrosine hydroxylase (Th)promoter was microinjected into SD ovocytes to generate 3 transgenic rat lines Rat Resource and Research Center transgenic Unknown RRID:RRRC_00634 7245523 SD-Tg(Th-SNCA*)4Ins the transgene overexpressing human mutated alpha-synuclein (A53T and A30P) under the control of rat tyrosine hydroxylase (Th)promoter was microinjected into SD ovocytes to generate 3 transgenic rat lines Rat Resource and Research Center transgenic Unknown RRID:RRRC_00635 7245527 WKHA/Edh derived from a cross between SHR/N and WKY/N starting in 1980; followed by selected brother/sister inbreedings from F2 generation forward, selecting WKHA for highest activity and lowest blood pressure Rat Resource and Research Center inbred Unknown RRID:RRRC_00663 7245556 WKHT/Edh WKHT rats are derived from a cross between SHR and WKY. Brother/sister inbreeding of the hybrids and successive generations was performed, selecting for the hypertension, but not the behavioral hyperactivity, of the SHR. Rat Resource and Research Center inbred Unknown RRID:RRRC_00664 7246924 HanTacFcfiq:WH Wistar Hannover Received from Taconic in 2001; bred according to the Poiley rotation (1960) with permanent monogamous mating. Universidade de Sao Paulo outbred Unknown RRID:RGD_7246924 7246927 NTacFcfiq:SD Sprague Dawley Received from Taconic in 2001; bred according to the Poiley rotation (1960) with permanent monogamous mating. Universidade de Sao Paulo outbred Unknown RRID:RGD_7246927 7246928 NTac:NIH-Foxn1rnu nude The NIH nude Spontaneous mutant model was developed by NIH in 1979-1980 by intercrossing eight strains of rats. Taconic received stock from NIH Animal Genetic Resource in 1981. The rats were derived by hysterectomy in 1987 and again in 1998. Animals are randomly bred at Taconic without selection for coat color or pigmentation. Taconic outbred Unknown RRID:RGD_7246928 7246929 NTacFcfiq:NIH-Foxn1rnu nude Received from Taconic in 2001; bred according to the Poiley rotation (1960) with permanent monogamous mating between homozygous male x heterozygous female. Universidade de Sao Paulo outbred Unknown RRID:RGD_7246929 7247278 SD-Tg(Camk2a-tTA)Xgx Camk2a-tTA transgenic rats expressing tTA under regulatory control of the forebrain promotor Camk2a. Transgene expression can be blocked by administration of doxycycline to drinking water. Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2019-02-18) RRID:RRRC_00655 7247279 SD-Tg(TRE-FUS-R521C)Xgx Overexpression of R521C mutant form of human FUS (Fused in Sarcoma) transgene is under regulatory control of tetracycline-responsive promoter element. Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2019-02-18) FUS 1318882 RRID:RRRC_00656 7247280 SD-Tg(TRE-LacZ)Xgx LacZ gene was assembled downstream of the TRE (tetracycline-responsive promoter elements) promoter, allowing inducible gene expression. Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2019-02-18) RRID:RRRC_00657 7247286 F344-Tg(APP)21Besey F344/NHsd embryos were microinjected with a DNA construct containing human beta amyloid precursor protein (APP), Swedish (Swe) double mutation (K670N-M671L) and Indiana (Ind) single autosomal dominant mutation (V642F). The transgene is driven by an ubiquitin-C promoter. Homozygous transgenic rats exhibit approximately 2.9-fold more expression of APP mRNA than wild-type rats. Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2019-02-05) APP 736021 RRID:RRRC_00636 7247289 SD-Tg(TETRA-EGFP)Besey SD embryos were microinjected with a DNA construct containing the GFP gene downstream of a miniCMV promoter under the control of tetracycline response element (TRE). The pLV-Tet-GFP was generated by co-transfection of pLV-Tet-GFP, pΔ8.9 and pVSV-G into a 293FT packaging cell line Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2019-02-18) RRID:RRRC_00650 7247290 SD-Tg(Ubc-P2ry2)Besey SD embryos were microinjected with a lentiviral construct containing the rat P2ry2 gene (G protein-coupled purinergic receptor P2Y2) under control of an ubiquitin-C promoter. Results in over-expression of P2ry2 mRNA. Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2017-08-22) P2ry2 62088 RRID:RRRC_00627 7247594 WKY.SHR-(D1Rat90-D1Mit18)/Iwai Fragment of the chromosome 1 derived from SHR and repeated backcross to WKY Shiga University of Medical Science, Otsu, Japan congenic Unknown 1 224426266 267111153 1 - by flanking markers 1 246118980 289137268 1 - by flanking markers 1 238830408 281795785 1 - by flanking markers 1 218753689 259647894 1 - by flanking markers RRID:RGD_7247594 7248453 SS.BN-(D12Hmgc3-AU047911)/Mcwi Subcongenic strain generated by backcrossing SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi to SS-Chr 12BN/Mcwi, intercrossing the F1 generation, and genotyping for recombinations; recombinant strain was backcrossed to SS-Chr 12BN/Mcwi and bred to homozygosity. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 12 15420627 15420833 1 - by flanking markers 12 17102817 19021770 1 - by flanking markers 12 15085585 17031347 1 - by flanking markers 12 13008296 14942487 1 - by flanking markers RRID:RGD_7248453 7248454 SS.BN-(D12Hmgc7-D12Hmgc6)/Mcwi Subcongenic strain generated by backcrossing SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi to SS-Chr 12BN/Mcwi, intercrossing the F1 generation, and genotyping for recombinations; recombinant strain was backcrossed to SS-Chr 12BN/Mcwi and bred to homozygosity. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 12 24299715 24300160 1 - by flanking markers 12 22283062 22283507 1 - by flanking markers 12 19212614 19212979 1 - by flanking markers RRID:RGD_7248454 7248456 SS.BN-(D12Hmgc3-D12Got29)/Mcwi Subcongenic strain generated by backcrossing SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi to SS-Chr 12BN/Mcwi, intercrossing the F1 generation, and genotyping for recombinations; recombinant strain was backcrossed to SS-Chr 12BN/Mcwi and bred to homozygosity. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 12 14395317 14395596 1 - by flanking markers 12 17102817 18009770 1 - by flanking markers 12 15085585 16012213 1 - by flanking markers 12 13008296 13925040 1 - by flanking markers RRID:RGD_7248456 7248716 NAK/Nokh Nodai aphakia This is an inbred anophthalmic rat strain derived from a Sprague-Dawley (SD) colony and designated it as Nodai aphakia (NAK) by Dr.Ryoichi Hashizume in Tokyo University of Agriculture. The NAK rats have decreased body size than wild-type rats and do not have both eyes. Faculty of Bioindustry, Tokyo University of Agriculture in Japan inbred Live Animals RRID:RGD_7248716 7248725 ACI.BN-(D7Rat164-D7Uwm27)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Live Animals (as of 2017-09-07) mammary cancer 7 69506936 69507070 1 - by flanking markers 7 72918736 72918869 1 - by flanking markers 7 72752037 72752170 1 - by flanking markers 7 65287247 65287381 1 - by flanking markers RRID:RGD_7248725 7248727 ACI.BN-(D7Rat164-D7Uwm30)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Live Animals (as of 2017-09-07) mammary cancer 7 69506936 69507070 1 - by flanking markers 7 72918736 72918869 1 - by flanking markers 7 72752037 72752170 1 - by flanking markers 7 65287247 65287381 1 - by flanking markers RRID:RGD_7248727 7248729 ACI.BN-(D7Rat206-D7Uwm30)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown mammary cancer 7 75357125 75357349 1 - by flanking markers 7 78786126 78786349 1 - by flanking markers 7 78758303 78758526 1 - by flanking markers 7 70840118 70840342 1 - by flanking markers RRID:RGD_7248729 7248731 ACI.BN-(D7Rat164-D7Uwm31)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown mammary cancer 7 69506936 69507070 1 - by flanking markers 7 72918736 72918869 1 - by flanking markers 7 72752037 72752170 1 - by flanking markers 7 65287247 65287381 1 - by flanking markers RRID:RGD_7248731 7248733 ACI.BN-(D7Rat164-D7Uwm33)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown mammary cancer 7 69506936 69507070 1 - by flanking markers 7 72918736 72918869 1 - by flanking markers 7 72752037 72752170 1 - by flanking markers 7 65287247 65287381 1 - by flanking markers RRID:RGD_7248733 7248736 ACI.BN-(D7Uwm32-D7Uwm27)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Live Animals (as of 2017-09-07) mammary cancer RRID:RGD_7248736 7248738 ACI.BN-(D7Uwm36-D7Uwm27)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Live Animals (as of 2017-09-07) mammary cancer RRID:RGD_7248738 7248740 ACI.BN-(D7Uwm38-D7Uwm27)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Live Animals (as of 2017-09-07) mammary cancer RRID:RGD_7248740 7248742 ACI.BN-(D7Uwm33-D7Mit27)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 7 98955068 98955278 1 - by flanking markers 7 103159379 103159589 1 - by flanking markers 7 102588240 102588450 1 - by flanking markers 7 93595631 93595843 1 - by flanking markers RRID:RGD_7248742 7248744 ACI.BN-(D7Uwm33-D7Uwm27)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Cryopreserved Sperm (as of 2017-09-07) mammary cancer RRID:RGD_7248744 7248746 ACI.BN-(D7Uwm41-D7Mit16)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Live Animals (as of 2017-09-07) mammary cancer 7 120745845 120746007 1 - by flanking markers 7 123587556 123587717 1 - by flanking markers 7 123602837 123602998 1 - by flanking markers 7 113886156 113886318 1 - by flanking markers RRID:RGD_7248746 7248748 ACI.BN-(D7Uwm28-D7Mit16)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Cryopreserved Sperm (as of 2017-09-07) mammary cancer 7 120745845 120746007 1 - by flanking markers 7 123587556 123587717 1 - by flanking markers 7 123602837 123602998 1 - by flanking markers 7 113886156 113886318 1 - by flanking markers RRID:RGD_7248748 7257663 WI-Tlr4em1Geh This strain was produced by TALEN mediated 13 bp deletion in Exon 1 in the rat Tlr4 gene; background strain is Crl:WI University of Pittsburgh, Rat Resource and Research Center mutant Unknown alcohol action, immune system function, septic shock Tlr4em1Geh 7257661 5 83564100 83577735 1 - by flanking markers 5 86690670 86704302 1 - by flanking markers 5 82587424 82601056 1 - by flanking markers 5 80145867 80159501 1 - by flanking markers RRID:RRRC_00694 7257722 WKY.SHR-(D1Mgh14-D1Rat77)/Iwai Fragment of the chromosome 1 derived from SHR/NCrlj and repeated backcross to WKY/NCrlCrlj Shiga University of Medical Science, Otsu, Japan congenic Unknown 1 238037373 263699089 1 - by flanking markers 1 259703519 285604895 1 - by flanking markers 1 252479838 278228889 1 - by flanking markers 1 231688927 256448636 1 - by flanking markers RRID:RGD_7257722 7349321 LEXF2D/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. Saitama Cancer Center Research Institute, Saitama, Japan recombinant_inbred Unknown RRID:RGD_7349321 7349322 LEXF8B/Stm This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. Saitama Cancer Center Research Institute, Saitama, Japan recombinant_inbred Unknown RRID:RGD_7349322 7349357 DA.PVG.1AV1-(D4Got128-D4Got136) Congenic substrain derived from marker assisted selection for PVG.1AV1 chromsome 4 alleles on the DA recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 159334251 160528447 1 - by flanking markers 4 222712454 223964695 1 - by flanking markers 4 155691688 156945571 1 - by flanking markers 4 156085418 157232313 1 - by flanking markers RRID:RGD_7349357 7364879 SS-Apoeem9Mcwi This strain was produced by injecting ZFNs targeting the sequence CAGGCCCTGAACCGCttctggGATTACCTGCGCTGGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 101-bp deletion in exon 2 and intron 3 PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Apoeem9Mcwi 7364878 1 79003634 79006387 1 - by flanking markers 1 81878372 81882298 1 - by flanking markers 1 80612894 80616820 1 - by flanking markers 1 79353924 79357852 1 - by flanking markers RRID:RGD_7364879 7364880 SS-Cst3em1Mcwi This strain was produced by injecting ZFNs targeting the sequence CTTCGCCGTAAGCGAGTAcaacaaGGGCAGCAACGAT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 18-bp deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Cst3em1Mcwi 5687708 3 137650903 137654776 1 - by flanking markers 3 149628692 149632565 1 - by flanking markers 3 143219671 143223544 1 - by flanking markers 3 136336923 136340796 1 - by flanking markers RRID:RGD_7364880 7364881 SS-Slc7a9em1Mcwi This strain was produced by injecting ZFNs targeting the sequence ATCGTCGCCATCATCATCatcagcGGACTGGTCCTCCTG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp frameshift deletion in exon 6. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Slc7a9em1Mcwi 5687700 1 87976440 87999102 1 - by flanking markers 1 92836837 92865759 1 - by flanking markers 1 91709034 91738492 1 - by flanking markers 1 88109517 88132653 1 - by flanking markers RRID:RGD_7364881 7364882 SS-Sorcs2em1Mcwi This strain was produced by injecting ZFNs targeting the sequence ATCGTCGCCATCATCATCatcagcGGACTGGTCCTCCTG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 34-bp frameshift deletion in exon 15. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Sorcs2em1Mcwi 5508343 14 79968072 80344330 1 - by flanking markers 14 79176694 79547823 1 - by flanking markers 14 79538911 79912333 1 - by flanking markers 14 74371089 74735943 1 - by flanking markers RRID:RGD_7364882 7364902 SS-Chr 2BN/1McwiAek Compared to the current SS-Chr 2BN/Mcwi colony at the Medical College of Wisconsin (where this strain originated) it is a more complete consomic strain (a smaller piece of distal Chromosome 2 is of the SS genotype compared to the SS-Chr 2BN/Mcwi strain). Rat Resource and Research Center consomic Cryopreserved Embryo (as of 2019-02-19) Studies of ischemia reperfusion injury or hypertension RRID:RRRC_00683 7364919 SS.BN-(rs64114288-rs107464428)/Aek This congenic strain contains a fragment of chromosome 2 of the SS-Chr 2BN/Mcwi from the top to ~227 Mb transferred to the SS/JrHsdMcwi strain background. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-19) cardiac ischemia 2 4393495 226787712 1 - by flanking markers 2 4122074 253120782 1 - by flanking markers 2 4124871 233798506 1 - by flanking markers RRID:RRRC_00686 7364923 SS.BN-(rs106982173-rs65057186)/Aek This congenic strain contains a fragment of chromosome 2 of the SS-Chr 2BN/Mcwi from ~95 to 219 Mb transferred to the SS/JrHsdMcwi strain background. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-19) cardiac ischemia 2 95437081 219011790 1 - by flanking markers 2 115311536 243978789 1 - by flanking markers 2 95571004 225944289 1 - by flanking markers RRID:RRRC_00685 7364927 SS.BN-(rs13453786-rs66377062)/Aek This congenic strain contains a fragment of chromosome 2 of the SS-Chr 2BN/Mcwi from ~95 to 219 Mb transferred to the SS/JrHsdMcwi strain background. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-19) cardiac ischemia 2 224440703 248978273 1 - by flanking markers 2 250808785 274502259 1 - by flanking markers 2 231460803 255813030 1 - by flanking markers RRID:RRRC_00684 7364932 ACI.BN-(D7Rat42-D7Uwm33)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Cryopreserved Sperm (as of 2017-09-07) mammary cancer 7 88132195 95760450 1 - by flanking markers 6 20168871 116858395 1 - by flanking markers 6 10173862 108696915 1 - by flanking markers 7 83153392 83153512 1 - by flanking markers RRID:RGD_7364932 7364934 ACI.BN-(rs199006987-D7Uwm27)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Live Animals (as of 2017-09-07) mammary cancer 7 98063531 98063531 1 - by flanking markers 7 101990558 101990558 1 - by flanking markers 7 101422284 101422284 1 - by flanking markers RRID:RGD_7364934 7364936 ACI.BN-(D7Arb15-D7Uwm27)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Cryopreserved Sperm (as of 2017-09-07) mammary cancer 7 96648929 96649150 1 - by flanking markers 7 100740218 100740438 1 - by flanking markers 7 100160221 100160441 1 - by flanking markers 7 91412389 91412612 1 - by flanking markers RRID:RGD_7364936 7364938 (LE x RCS-p+/LavRrrc)F1 RCS-p+/LavRrrc males were mated to LE females. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-18) Retinal Research Mertk 69283 RRID:RRRC_00662 7364940 F344-Tp53tm1(EGFP-Pac)Qly/Rrrc Backcrossed STOCK-Tp53tm1(EGFP-Pac)QlyRrrc with F344 using speed congenic approach to move mutation onto F344 genetic background. Rat Resource and Research Center mutant Unknown tumorigenesis model RRID:RRRC_00661 7364954 DA.ACI-(D2Mit12-D2Got121)/Nsi Congenic strain created by backcrossing DA/BklArbNsi and ACI/SegHsd 7 times then brother-sister mating to maintain in the homozygous state North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-18) arthritis/autoimmunity studies 2 174730375 193841840 1 - by flanking markers 2 201404917 220662282 1 - by flanking markers 2 181990297 201193787 1 - by flanking markers 2 168358098 186483643 1 - by flanking markers RRID:RRRC_00668 7364956 DA.ACI-(D2Wox20-D2Mit14)/Nsi Congenic strain created by backcrossing DA/BklArbNsi and ACI/SegHsd 10 times then brother-sister mating to maintain in the homozygous state North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-18) arthritis/autoimmunity studies 2 181213221 197256313 1 - by flanking markers 2 207864396 224018437 1 - by flanking markers 2 188448030 204585731 1 - by flanking markers 2 174541858 189599348 1 - by flanking markers RRID:RRRC_00669 7364959 DA.ACI-(D2Uwm24-D2Rat54)/Nsi Congenic strain created by backcrossing DA/BklArbNsi and ACI/SegHsd 8 times then brother-sister mating to maintain in the homozygous state North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-18) arthritis/autoimmunity studies 2 198168347 210012267 1 - by flanking markers 2 224860752 234970326 1 - by flanking markers 2 205430606 216878775 1 - by flanking markers 2 190460423 201836059 1 - by flanking markers RRID:RRRC_00670 7364970 DA.ACI-(D12Mit2-D12Got49)/Nsi Congenic strain created by backcrossing DA/BklArbNsi and ACI/SegHsd 12 times then brother-sister mating to maintain in the homozygous state North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-18) arthritis/autoimmunity studies 12 20932559 24257553 1 - by flanking markers 12 24662983 28081151 1 - by flanking markers 12 22650702 26079250 1 - by flanking markers 12 19610870 23060532 1 - by flanking markers RRID:RRRC_00671 7364974 DA.F344-(D10Rat195-D10Rat92)/Nsi Congenic strain created by backcrossing F344/NHsd into DA/BklArbNsi 8 times then brother-sister mating to maintain in the homozygous state North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-19) arthritis/autoimmunity studies 10 63690620 78170722 1 - by flanking markers 10 66394066 77132664 1 - by flanking markers 10 65234285 77269936 1 - by flanking markers 10 62541890 74586024 1 - by flanking markers RRID:RRRC_00676 7364976 DA.F344-(D10Rat195-D10Arb27)/Nsi Congenic strain created by backcrossing F344 into DA/BklArbNsi 8 times then brother-sister mating to maintain in the homozygous state North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-19) arthritis/autoimmunity studies 10 63690620 69160517 1 - by flanking markers 10 66394066 67971488 1 - by flanking markers 10 65234285 68305173 1 - by flanking markers 10 62541890 65927370 1 - by flanking markers RRID:RRRC_00677 7364978 DA.F344-(D10Arb27-D10Rat92)/Nsi Congenic strain created by backcrossing F344 into DA/BklArbNsi 8 times then brother-sister mating to maintain in the homozygous state North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-19) arthritis/autoimmunity studies 10 69160380 78170722 1 - by flanking markers 10 67971352 77132664 1 - by flanking markers 10 68305037 77269936 1 - by flanking markers 10 65927233 74586024 1 - by flanking markers RRID:RRRC_00678 7364981 DA.F344-(D7Rat22-D7Rat15)/Nsi Congenic strain created by backcrossing F344/NHsd into DA/BklArbNsi 11 times then brother-sister mating to maintain in the homozygous state The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-19) arthritis/autoimmunity studies 7 76615341 107428439 1 - by flanking markers 7 110975825 110975995 1 - by flanking markers 7 111043360 111043530 1 - by flanking markers 7 101772987 101773158 1 - by flanking markers RRID:RRRC_00680 7364991 ACI/EurMcwi ACI (August × Copenhagen Irish) substrain of ACI derived from ACI/Eur Medical College of Wisconsin, Rat Resource & Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm Renal disease RRID:RRRC_00284 7365040 SS.SR-(rs65785750-rs13452155)/Opaz Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2021-05-07) 5 106408365 138369243 1 - by flanking markers 5 109436629 140527096 1 - by flanking markers 5 105452223 136738047 1 - by flanking markers RRID:RGD_7365040 7365043 SS.SR-(rs65785750-rs106808193)/Opaz Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-05) 5 106408365 141744732 1 - by flanking markers 5 109436629 143913027 1 - by flanking markers 5 105452223 140120264 1 - by flanking markers RRID:RGD_7365043 7394698 ZUC.BN-(D1Rat42-D1Rat90)/Ste homozygous lean wild-type ZUC-Lepr+Ste were crossed with BN/Crl to get F1; these were backcrossed to lean ZUC males; congenics were selected by genotyping with markers University of California Davis, Davis, CA congenic Unknown 1 135418152 267111153 1 - by flanking markers 1 142342107 289137268 1 - by flanking markers 1 141381406 281795785 1 - by flanking markers 1 133587283 259647894 1 - by flanking markers RRID:RGD_7394698 7394818 P.NP-(D4Mgh16-D4Rat173)/Iusm P.NP-(D4Rat119-D4Rat55)/Iusm and iP rats were crossed to get F1 animals which were further backcrossed to iP rats for 10 generations, this was followed by intercross to generate the congenic strains, these animals were selected by marker-assisted selection Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana congenic Unknown 4 61646674 92716873 1 - by flanking markers 4 61427427 158932336 1 - by flanking markers 4 61708103 94143659 1 - by flanking markers 4 62933269 92489678 1 - by flanking markers RRID:RGD_7394818 7394821 P.NP-(Snca-D4Rat35)/Iusm P.NP-(D4Rat119-D4Rat55)/Iusm and iP rats were crossed to get F1 animals which were further backcrossed to P rats for 10 generations, this was followed by intercross to generate the congenic strains, these animals were selected by marker-assisted selection Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana congenic Unknown Snca 3729 4 89613731 91336908 1 - by flanking markers 4 155592411 157297332 1 - by flanking markers 4 90782412 92490285 1 - by flanking markers 4 89696420 91366774 1 - by flanking markers RRID:RGD_7394821 7401201 SS.SR-(D17Rat24-rs106534785)/Opaz Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-05) 17 57724628 71942842 1 - by flanking markers 17 50489557 65074022 1 - by flanking markers 17 52424553 63306062 1 - by flanking markers 17 49567911 49568080 1 - by flanking markers RRID:RRRC_00615 7401203 SS.SR-(rs105019230-D17Rat44)/Opaz Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains. Rat Resource and Research Center Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts. congenic Cryopreserved Sperm (as of 2021-05-07) 17 63080042 81612488 1 - by flanking markers 17 55371177 75653670 1 - by flanking markers 17 57343133 73981731 1 - by flanking markers 17 70156777 70156904 1 - by flanking markers RRID:RRRC_00616 7401261 LOU/NimrOlaHsd Louvain LOU/C was selected for high immunocytoma incidence; to National Institute of Medical Research, Mill Hill; in 1985 from Nimr to Harlan Envigo inbred Cryorecovery RRID:RGD_7401261 7411634 WDB/Nips Crlj:WI females were bred to DA/Slc males to generate F1 pups which were bred by brother-sister mating; only black (non-agouti) pups were picked for breeding. (The genotype of the pups was checked by backcrossing to BN (for BB or Bb) and Hooded strains (for HH or Hh) genotype.) When the aaBBCCHH genotype of F2 was confirmed then the strain was maintained by brother-sister mating. Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN inbred Unknown RRID:RGD_7411634 7411676 SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc Congenic strain created by speed congenic strategy where the desired region from Chromosome 3 of WKY/Gcrc was introgressed into the SHRSP/Gcrc background. University of Glasgow, Western Infirmary, Glasgow, UK congenic Unknown 3 6373335 149496698 1 - by flanking markers 3 11361699 160347840 1 - by flanking markers 3 6000748 155263151 1 - by flanking markers 3 10778704 147415807 1 - by flanking markers RRID:RGD_7411676 7411679 SHRSP.WKY-(D2Rat13-D2Rat157)(D3Mgh16-D3Rat114)/Gcrc F1 rats generated by crossing SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc and SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc were backcrossed to SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc; heterozygous animals for chr 3 fragment were crossed with homozygous animals for chr 2; animals that were homozygous for both fragments were intercrossed to get the desired bicongenic strain University of Glasgow, Western Infirmary, Glasgow, UK congenic Unknown RRID:RGD_7411679 7411703 SHRSP.SHR-(D1Rat93-D1Rat269)(D18Rat73-D18Rat11)/Izm constructed by crossing and backcrossing the congenic strains for chr 1 and chr 18 segments Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio-Hypertension 18;1 52290789;63990899 71692408;126292805 1 - by flanking markers;1 - by flanking markers 18;1 50804228;63244295 69942605;133485967 1 - by flanking markers;1 - by flanking markers 18;1 51609032;64252881 70803264;132448306 1 - by flanking markers;1 - by flanking markers 1;18 65677942;49999958 124977364;68414117 1 - by flanking markers;1 - by flanking markers RRID:RGD_7411703 7411705 SHR.SHRSP-(D1Rat93-D1Rat269)(D18Rat73-D18Rat11)/Izm constructed by crossing and backcrossing the congenic strains for chr 1 and chr 18 segments Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan, National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cardio-Hypertension 18;1 52290789;63990899 71692408;126292805 1 - by flanking markers;1 - by flanking markers 18;1 50804228;63244295 69942605;133485967 1 - by flanking markers;1 - by flanking markers 18;1 51609032;64252881 70803264;132448306 1 - by flanking markers;1 - by flanking markers 1;18 65677942;49999958 124977364;68414117 1 - by flanking markers;1 - by flanking markers RRID:RGD_7411705 7411707 SHRSP.SHR-(D1Mgh5-D1Got87)/Izm male SHRSP.SHR-(D1Rat93-D1Rat269)/Izm were crossed with female SHRSP/Izm and the offsprings were intercrossed, animals were genotyped to get the desired recombinants which were then backcrossed to SHRSP/Izm Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio-Hypertension 1 78134304 85828306 1 - by flanking markers 1 80946174 92291485 1 - by flanking markers 1 79689548 91156803 1 - by flanking markers 1 78430536 86030749 1 - by flanking markers RRID:RGD_7411707 7411709 SHRSP.SHR-(D1Mit30-D1Rat269)/Izm male SHRSP.SHR-(D1Rat93-D1Rat269)/Izm were crossed with female SHRSP/Izm and the offsprings were intercrossed, animals were genotyped to get the desired recombinants which were then backcrossed to SHRSP/Izm Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio-Hypertension 1 94473940 126292805 1 - by flanking markers 1 101048742 133485967 1 - by flanking markers 1 99983293 132448306 1 - by flanking markers 1 94494440 124977364 1 - by flanking markers RRID:RGD_7411709 7421599 SS.LEW-(D1Chm64-D1Rat19)/Ayd A segment of chromosome 1 was transferred from LEW/Crlc into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 1 43872710 43872827 1 - by flanking markers 1 50173150 50173266 1 - by flanking markers 1 49578577 49578693 1 - by flanking markers 1 49393172 49393289 1 - by flanking markers RRID:RGD_7421599 7421603 SS.LEW-(D1Rat320-D1Mgh32)/Ayd A segment of chromosome 1 was transferred from LEW/Crlc into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 1 119536684 247882384 1 - by flanking markers 1 126980427 269885827 1 - by flanking markers 1 125875758 262433692 1 - by flanking markers 1 118608292 241799120 1 - by flanking markers RRID:RGD_7421603 7421606 SS.LEW-(D1Uia4-D1Rat320)/Ayd A segment of chromosome 1 was transferred from LEW/Crlc into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 1 64343599 119536913 1 - by flanking markers 1 63580258 126980655 1 - by flanking markers 1 64588516 125875986 1 - by flanking markers 16;1;5;9 58114204;66023617;146042096;17435338 58114246;118608521;146042138;17435380 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers;1 - by flanking markers RRID:RGD_7421606 7421610 SS.LEW-(D5Mit5-D5M4Mit14)/Ayd A segment of chromosome 5 was transferred from LEW/Crlc into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 5 109163281 109163425 1 - by flanking markers 5 112057862 112058005 1 - by flanking markers 5 108092659 108092802 1 - by flanking markers 5 104250862 104251008 1 - by flanking markers RRID:RGD_7421610 7421612 SS.LEW-(D16Chm48-D16Chm60)/Ayd A segment of chromosome 16 was transferred from LEW/Crlc into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 16 2116303 3165043 1 - by flanking markers 16 2471921 3491557 1 - by flanking markers 16 3524957 3525217 1 - by flanking markers 16 3080416 3080679 1 - by flanking markers RRID:RGD_7421612 7421617 SS.LEW-(D17Chm14-D17Rat65)/Ayd A segment of chromosome 17 was transferred from LEW/Crlc into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 17 80181988 93930006 1 - by flanking markers 17 74265283 88435496 1 - by flanking markers 17 72580584 86731080 1 - by flanking markers 17 68783937 82479847 1 - by flanking markers RRID:RGD_7421617 7421619 SS.LEW-(D17Chm85-D17Chm71)/Ayd A segment of chromosome 17 was transferred from LEW/Crlc into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown RRID:RGD_7421619 7421621 SS.LEW-(D17Chm131-D17Chm93)/Ayd A segment of chromosome 17 was transferred from LEW/Crlc into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown RRID:RGD_7421621 7421623 SS.LEW-(D17Rat84-D17Chm17)/Ayd A segment of chromosome 17 was transferred from LEW/Crlc into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 17 29603712 29604237 1 - by flanking markers 17 23473207 23473342 1 - by flanking markers 17 21490950 21491085 1 - by flanking markers 17 23653184 23653323 1 - by flanking markers RRID:RGD_7421623 7421634 SS.MNS-(D2Got93-D2Rat222)/Ayd A segment of chromosome 2 was transferred from MNS/N into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 2 140672373 145318823 1 - by flanking markers 2 160649967 164927046 1 - by flanking markers 2 140958240 145514793 1 - by flanking markers 2 135818873 140253961 1 - by flanking markers RRID:RGD_7421634 7421636 SS.MNS-(D2Chm90-D2Rat38)/Ayd A segment of chromosome 2 was transferred from MNS/N into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 2 147424195 155102371 1 - by flanking markers 2 167706439 175354471 1 - by flanking markers 2 148295267 155965721 1 - by flanking markers 2 142323368 149559726 1 - by flanking markers RRID:RGD_7421636 7421638 SS.MNS-(D2Chm381-D2Chm225)/Ayd A segment of chromosome 2 was transferred from MNS/N into the SS/Jr background, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 2 156267173 156267340 1 - by flanking markers 2 177626917 177627084 1 - by flanking markers 2 158268536 158268703 1 - by flanking markers 2 150649899 150650069 1 - by flanking markers RRID:RGD_7421638 7421640 SS.MNS-(D2Rat155-D2Chm161)/Ayd Congenic substrain created by backcrossing congenic strain SS.MNS-(D2Chm25-D2Mit14)/Ayd strain into the parental Dahl Salt-sensitive (SS/Jr) strain, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 2 179581946 179582150 1 - by flanking markers 2 206293779 206293982 1 - by flanking markers 2 186889035 186889238 1 - by flanking markers 2 172982062 172982266 1 - by flanking markers RRID:RGD_7421640 7421643 SS.MNS-(D2Chm254-D2Chm161)/Ayd Congenic substrain created by backcrossing congenic strain SS.MNS-(D2Chm25-D2Mit14)/Ayd strain into the parental Dahl Salt-sensitive (SS/Jr) strain, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown RRID:RGD_7421643 7421645 SS.MNS-(D2Rat155-D2Chm419)/Ayd Congenic substrain created by backcrossing congenic strain SS.MNS-(D2Chm25-D2Mit14)/Ayd strain into the parental Dahl Salt-sensitive (SS/Jr) strain, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 2 179581946 179582150 1 - by flanking markers 2 206293779 206293982 1 - by flanking markers 2 186889035 186889238 1 - by flanking markers 2 172982062 172982266 1 - by flanking markers RRID:RGD_7421645 7421647 SS.MNS-(D2Chm161-D2Chm410)/Ayd Congenic substrain created by backcrossing congenic strain SS.MNS-(D2Chm25-D2Mit14)/Ayd strain into the parental Dahl Salt-sensitive (SS/Jr) strain, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown RRID:RGD_7421647 7421649 SS.MNS-(D2Chm153-D2Chm410)/Ayd Congenic substrain created by backcrossing congenic strain SS.MNS-(D2Chm25-D2Mit14)/Ayd strain into the parental Dahl Salt-sensitive (SS/Jr) strain, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown RRID:RGD_7421649 7421651 SS.MNS-(D2Chm442-D2Chm410)/Ayd Congenic substrain created by backcrossing congenic strain SS.MNS-(D2Chm25-D2Mit14)/Ayd strain into the parental Dahl Salt-sensitive (SS/Jr) strain, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown RRID:RGD_7421651 7421654 SS.MNS-(D2Chm366-D2Rat52)/Ayd Congenic substrain created by backcrossing congenic strain SS.MNS-(D2Chm25-D2Mit14)/Ayd strain into the parental Dahl Salt-sensitive (SS/Jr) strain, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown 2 200866667 200866813 1 - by flanking markers 2 227502003 227502148 1 - by flanking markers 2 208081050 208081195 1 - by flanking markers 2 193094852 193094998 1 - by flanking markers RRID:RGD_7421654 7771589 SS.SR-(D2Rat352-rs63922710)/Opaz Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains Boston University School of Medicine, Boston, Massachusetts. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-05) 2 173606885 196312011 1 - by flanking markers 2 200318348 223091129 1 - by flanking markers 2 180909971 203646445 1 - by flanking markers 2 167282560 167282768 1 - by flanking markers RRID:RRRC_00610 7771600 SS.SR-(rs106870553-rs63922710)/Opaz Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains Boston University School of Medicine, Boston, Massachusetts. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2019-02-05) 2 176635705 196312011 1 - by flanking markers 2 203270720 223091129 1 - by flanking markers 2 183864092 203646445 1 - by flanking markers RRID:RRRC_00611 7771610 SHRSP-Chr 1F344/Rkb SHRSP/Bbb male was crossed with female F344/Crl to get F1 animals which in turn were backcrossed with female SHRSP, this was repeated for 7 generations, tested by sequential marker-assisted backcrossing Department of Clinical Pharmacology and Toxicology, Charite-Universitatsmedizin Berlin, Berlin, Germany consomic Unknown RRID:RGD_7771610 7777135 SS.LEW-(D5Mco39-D5Mco57)/1Mco SS.LEW-(D5Mco34-D5Rat108)/Jr was selectively backcrossed with the SS/Jr strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 0 0 1 - by flanking markers RRID:RGD_7777135 7777138 SS.LEW-(D5Mco41-D5Mco47)/Mco SS.LEW-(D5Mco34-D5Rat108)/Jr was selectively backcrossed with the SS/Jr strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 0 0 1 - by flanking markers 5 116151523 122679716 1 - by flanking markers 5 112175328 117913688 1 - by flanking markers RRID:RGD_7777138 7777140 SS.LEW-(D5Mco39-D5Mco57)(D5Mco41-D5Mco47)/Mco male and female pairs of the monocongenic SS.LEW-(D5Mco39-D5Mco57)/1Mco and SS.LEW-(D5Mco41-D5Mco47)/Mco were randomly selected and intercrossed to get F1; the heterozygous animals for the desired region were intercrossed to get the bicongenics Medical College of Ohio, Toledo, Ohio, USA congenic Unknown RRID:RGD_7777140 7777143 SS.LEW-(D5Mco39-D5Mco57)/2Mco SS.LEW-(D5Mco34-D5Rat108)/Jr was selectively backcrossed with the SS/Jr strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 0 0 1 - by flanking markers RRID:RGD_7777143 7777180 SS.LEW-(D5Mco42-D5Mco47)/1Mco SS.LEW-(D5Mco34-D5Rat108)/Jr was selectively backcrossed with the SS/Jr strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 0 0 1 - by flanking markers 5 116151523 120258299 1 - by flanking markers 5 112175328 116047316 1 - by flanking markers RRID:RGD_7777180 7794691 SS.LEW-(D5Mco39-D5Mco57)(D5Mco42-D5Mco47)/Mco male and female pairs of the monocongenic SS.LEW-(D5Mco39-D5Mco57)/2Mco and SS.LEW-(D5Mco42-D5Mco47)/1Mco were randomly selected and intercrossed to get F1; the heterozygous animals for the desired region were intercrossed to get the bicongenics Medical College of Ohio, Toledo, Ohio, USA congenic Unknown RRID:RGD_7794691 7794694 SS.LEW-(D5Mco39-D5Mco57)/3Mco SS.LEW-(D5Mco34-D5Rat108)/Jr was selectively backcrossed with the SS/Jr strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 0 0 1 - by flanking markers RRID:RGD_7794694 7794696 SS.LEW-(D5Mco43-D5Mco47)/Mco SS.LEW-(D5Mco34-D5Rat108)/Jr was selectively backcrossed with the SS/Jr strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 0 0 1 - by flanking markers 5 116151523 116151740 1 - by flanking markers 5 112175328 112175546 1 - by flanking markers RRID:RGD_7794696 7794698 SS.LEW-(D5Mco39-D5Mco57)(D5Mco43-D5Mco47)/Mco male and female pairs of the monocongenic SS.LEW-(D5Mco39-D5Mco57)/3Mco and SS.LEW-(D5Mco413-D5Mco47)/Mco were randomly selected and intercrossed to get F1; the heterozygous animals for the desired region were intercrossed to get the bicongenics Medical College of Ohio, Toledo, Ohio, USA congenic Unknown RRID:RGD_7794698 7794700 SS.LEW-(D5Mco39-D5Mco41)/Mco SS.LEW-(D5Mco34-D5Rat108)/Jr was selectively backcrossed with the SS/Jr strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 0 0 1 - by flanking markers 5 122679504 122679716 1 - by flanking markers 5 117913475 117913688 1 - by flanking markers RRID:RGD_7794700 7794704 SS.LEW-(D5Mco42-D5Mco47)/2Mco SS.LEW-(D5Mco34-D5Rat108)/Jr was selectively backcrossed with the SS/Jr strain Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 5 0 0 1 - by flanking markers 5 116151523 120258299 1 - by flanking markers 5 112175328 116047316 1 - by flanking markers RRID:RGD_7794704 7794706 SS.LEW-(D5Mco39-D5Mco41)(D5Mco42-D5Mco47)/Mco male and female pairs of the monocongenic SS.LEW-(D5Mco39-D5Mco41)/Mco and SS.LEW-(D5Mco42-D5Mco47)/2Mco were randomly selected and intercrossed to get F1; the heterozygous animals for the desired region were intercrossed to get the bicongenics Medical College of Ohio, Toledo, Ohio, USA congenic Unknown RRID:RGD_7794706 7800659 F344.Cg-Du, TyrC/Kyo downunder rat Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2016-11-10) Development RRID:RGD_7800659 7800661 F344.Cg-Du, TyrCKyo+/+ downunder rat Developed by the DEPOSITOR National BioResource Project for the Rat in Japan mutant Unknown RRID:RGD_7800661 7800667 F344.Cg-Foxn1rnuKyo-/+ Jic N13 to Kyo (1988) National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm Immunology; Cancer Foxn1 3970 RRID:RGD_7800667 7800671 F344-Sv2am1Kyo Established by ENU mutagenesis. A missense mutation (L174Q) mutation in Sv2a: synaptic vesicle glycoprotein 2a, was identified. National BioResource Project for the Rat in Japan mutant Unknown Sv2a|Sv2am1Kyo 619715|12792962 2 190989187 191000859 1 - by flanking markers 2 217808165 217823872 1 - by flanking markers 2 198321100 198336889 1 - by flanking markers 2 183741455 183757290 1 - by flanking markers RRID:RGD_7800671 7800673 KFRS2/Kyo-/+ KFRS2-/+ A male rat "SRR-Do Your Best" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "SRR-Do Your Best" and a female PVG/Seac. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm Ophthalmology; Dermatology Tyr|TyrsiaKyo 1589755|13207345 1 143641257 143746315 1 - by flanking markers 1 157322968 157416594 1 - by flanking markers 1 151012598 151106802 1 - by flanking markers 1 141115036 141210207 1 - by flanking markers RRID:RGD_7800673 7800676 KFRS3A/Kyo+/+ A male rat "SRR-Rocket Science" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "SRR-Rocket Science" and a female PVG/Seac. Homozygous rats for mink were selected for inbreeding. National BioResource Project for the Rat in Japan mutant Unknown RRID:RGD_7800676 7800692 MKO/Tami Minko Rat MKO rat is derived from Wistar male rat which exhibited large-size and abnormal lipid metabolism. National BioResource Project for the Rat in Japan inbred Live Animals; Cryopreserved Embryo RRID:RGD_7800692 7800694 NER.F344-(D1Rat132)(D5Rat100)/Kyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Unknown RRID:RGD_7800694 7800702 KHR/Kyo-/- kaken hairless rat Kaken hairless rat were detected by Kimura from Gunn's rat at Kaken Pharmaceuticals in 1987. 2002 introduced to Kyoto University (F36). National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Dermatology Oca2 2318412 1 115683593 115991040 1 - by flanking markers 1 114661970 114987433 1 - by flanking markers 1 107116278 107446093 1 - by flanking markers RRID:RGD_7800702 7800705 KHR/Kyo-/+ kaken hairless rat Kaken hairless rat were detected by Kimura from Gunn's rat at Kaken Pharmaceuticals in 1987. 2002 introduced to Kyoto University (F36). National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Dermatology Oca2 2318412 1 115683593 115991040 1 - by flanking markers 1 114661970 114987433 1 - by flanking markers 1 107116278 107446093 1 - by flanking markers RRID:RGD_7800705 8142383 SHRSP/BbbUtx Animals transferred from Harvard University/Brigham (Dr Klaus Lindpaintner) originating from SHRSP colony at University of Heidelberg University of Texas, Houston, TX inbred Unknown RRID:RGD_8142383 8142385 SHR/Utx Animals transferred from Professor T. Suzuki, Kinki University School of Medicine, Kinki, Japan in 2002, descended from the original SHR sub-strains reported by Okamoto, 1974 University of Texas, Houston, TX inbred Unknown RRID:RGD_8142385 8547938 CrljJcl:SD Sprague-Dawley from Charles River Laboratory Japan, to CLEA Japan, Inc. CLEA Japan, Inc outbred Live Animals (as of 2021-04-22) RRID:RGD_8547938 8548794 F344-Tg(NC1-269B17)1Nkg BAC clone NC1-269B17 which containing about 120 kb of ACI/NJcl rat-derived Casp3 (caspase 3) was injected into F344/Jcl embryos. The founder rat was backcrossed into F344/Jcl rat to establish the transgenic strain. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Casp3 2275 RRID:RGD_8548794 8548809 F344-Tg(NC1-269B17)2Nkg BAC clone NC1-269B17 which containing about 120 kb of ACI/NJcl rat-derived Casp3 (caspase 3) was injected into F344/Jcl embryos. The founder rat was backcrossed into F344/Jcl rat to establish the transgenic strain. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Casp3 2275 RRID:RGD_8548809 8548812 F344-Tg(NC1-269B17)3Nkg BAC clone NC1-269B17 which containing about 120 kb of ACI/NJcl rat-derived Casp3 (caspase 3) was injected into F344/Jcl embryos. The founder rat was backcrossed into F344/Jcl rat to establish the transgenic strain. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Casp3 2275 RRID:RGD_8548812 8548815 F344-Tg(NC1-269B17)4Nkg BAC clone NC1-269B17 which containing about 120 kb of ACI/NJcl rat-derived Casp3 (caspase 3) was injected into F344/Jcl embryos. The founder rat was backcrossed into F344/Jcl rat to establish the transgenic strain. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Casp3 2275 RRID:RGD_8548815 8548817 KDP.PVG-RT1a/u/Nyo MHC haplotype (RT1.BaDa) of PVG.R23 was transferred onto the genetic background of KDP/Tky strain (RT1.BuDu). This allele has been maintained in heterozygous condition. Backcrossing has started since 2003 and afterwards maintained by sib mating National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity RRID:RGD_8548817 8549599 BN.LEW-(D10Rat32-D10Rat133)/Ciml Congenic strain created from parental BN/Rj and LEW/Rj strains. Institut National de la Sante et de la Recherche Medicale, Toulouse, France congenic Unknown 10 53786347 65668639 1 - by flanking markers 10 53381898 64823355 1 - by flanking markers 10 53630865 53631032 1 - by flanking markers 10 51779662 51779830 1 - by flanking markers RRID:RGD_8549599 8549776 F344-Lepm1Kyo F344 OB rat Established by ENU mutagenesis in F344/NSlc rats. This strain has Lep missense mutation (Q92X). National BioResource Project for the Rat in Japan mutant Live Animals (as of 2017-03-17) Diabetes Obesity Lep|Lepm1Kyo 3000|12792963 4 55943837 55945938 1 - by flanking markers 4 56085079 56099209 1 - by flanking markers 4 56337695 56351818 1 - by flanking markers 4 57661127 57675262 1 - by flanking markers RRID:RGD_8549776 8549778 PVG.KDP-Cblb/Nyo PVG.KDP-Cblb congenic Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo Diabetes Obesity Cblb 620535 RRID:RGD_8549778 8549779 DRU/Uubc The mutant rat showing microphthalmia was found in the colony of Donryu rats at Central Institute for Experimental Animals in 1974. A pair of F3 rats was transferred to The Third Department for Anatomy, School of Medicine, Chiba University in 1975 and maintained by sib mating. F50 rats were transferred to Faculty of Agriculture, Utsunomiya University by Dr. S Sugita in 1991 National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo RRID:RGD_8549779 8549782 SD.Gunn-Ugt1a1j/Aon Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2017-09-15) Neurobiology; Metabolism Ugt1a1|Ugt1a1j 3935|13432064 RRID:RGD_8549782 8549785 W.Gunn-Ugt1a1j/Aon Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Unknown Neurobiology; Metabolism Ugt1a1|Ugt1a1j 3935|13432064 RRID:RGD_8549785 8549798 WMS/SimNcp Munich, Germany from Wistar stock selectively bred for superficial glomeruli. To Simonsen Labs, CA via Veterans Administration Medical Center, San Francisco, California in 1979 at which time inbreeding was begun. Transferred at Nigata University from Simonsen Laboratory in 2005. at Niigata University Department of cellular physiology, Institute of Nephrology, Niigata University, Niigata, Japan, National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo RRID:RGD_8549798 8551711 SS.LEW-(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D10Rat194-D10Chm243)/Ayd and SS.LEW-(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551711 8551714 SS.LEW-(D10Chm10-D10Rat11)(D10Chm246-D10Chm257)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D10Chm10-D10Rat11)/Ayd and SS.LEW-(D10Chm246-D10Chm257)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551714 8551716 SS.LEW-(D10Rat194-D10Chm243)(D16Chm48-D16Chm60)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D10Rat194-D10Chm243)/Ayd and SS.LEW-(D16Chm48-D16Chm60)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551716 8551718 SS.LEW-(D10Chm10-D10Rat11)(D16Chm48-D16Chm60)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D10Chm10-D10Rat11)/Ayd and SS.LEW-(D16Chm48-D16Chm60)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551718 8551721 SS.LEW-(D8Rat58-D8Chm12)(D10Chm10-D10Rat11)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D8Rat58-D8Chm12)/Ayd and SS.LEW-(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551721 8551723 SS.LEW-(D8Rat58-D8Chm12)(D10Rat194-D10Chm243)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D8Rat58-D8Chm12)/Ayd and SS.LEW-(D10Rat194-D10Chm243)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551723 8551725 SS.LEW-(D8Chm12-D8Rat15)(D10Rat194-D10Chm243)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D8Chm12-D8Rat15)/Ayd and SS.LEW-(D10Rat194-D10Chm243)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551725 8551727 SS.LEW-(D3Rat2-D3Chm79)(D10Rat194-D10Chm243)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D3Rat2-D3Chm79)/Ayd and SS.LEW-(D10Rat194-D10Chm243)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551727 8551730 SS.LEW-(D3Rat2-D3Chm79)(D10Chm10-D10Rat11)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D3Rat2-D3Chm79)/Ayd and SS.LEW-(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551730 8551732 SS.LEW-(D17Chm131-D17Chm93)(D10Chm10-D10Rat11)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D17Chm31-D17Chm93)/Ayd and SS.LEW-(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551732 8551734 SS.LEW-(D17Chm131-D17Chm93)(D17Rat84-D17Chm17)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D17Chm31-D17Chm93)/Ayd and SS.LEW-(D17Rat84-D17Chm17)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551734 8551737 SS.LEW-(D2Uia5-D2Mit6)(D10Chm10-D10Rat11)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D2Uia5-D2Mit6)/Ayd and SS.LEW-(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551737 8551739 SS.LEW-(D2Uia5-D2Mit6)(D10Rat194-D10Chm243)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D2Uia5-D2Mit6)/Ayd and SS.LEW-(D10Rat194-D10Chm243)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551739 8551742 SS.LEW-(D16Chm48-D16Chm60)(D18Rat101-D18Rat92)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D16Chm48-D16Chm60)/Ayd and SS.LEW-(D18Rat101-D18Rat92)/Ayd Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown RRID:RGD_8551742 8551748 SS.LEW-(D3Rat17-D3Mco80)(D10Rat194-D10Chm243)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D3Rat17-D3Mco80)/Ayd and SS.LEW-(D10Rat194-D10Chm243)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551748 8551750 SS.LEW-(D1Uia4-D1Rat320)(D10Chm10-D10Rat11)/Ayd A double congenic strain derived from the progenitor strain SS.LEW-(D1Uia4-D1Rat320)/Ayd and SS.LEW-(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551750 8551752 SS.LEW-(D1Rat320-D1Mgh32)(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd A triple congenic strain derived from the progenitor strain SS.LEW-(D1Rat320-D1Mgh32)/Ayd and SS.LEW-(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551752 8551755 SS.LEW-(D1Chm64-D1Rat19)(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd A triple congenic strain derived from the progenitor strain SS.LEW-(D1Chm64-D1Rat19)/Ayd and SS.LEW-(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551755 8551757 SS.LEW-(D7Uia3-D7Mgh1)(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd A triple congenic strain derived from the progenitor strain SS.LEW-(D7Uia3-D7Mgh1)/Ayd and SS.LEW-(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551757 8551759 SS.MNS-(D2Chm90-D2Rat38),LEW-(D10Chm10-D10Rat11)/Ayd A double congenic strain derived from the progenitor strain SS.MNS-(D2Chm90-D2Rat38)/Ayd and SS.LEW-(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551759 8551761 SS.MNS-(D2Chm90-D2Rat38),LEW-(D10Got112-Igfbp4)/Ayd A double congenic strain derived from the progenitor strain SS.MNS-(D2Chm90-D2Rat38)/Ayd and SS.LEW-(D10Got112-Igfbp4)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551761 8551763 SS.MNS-(D2Rat155-D2Chm419),LEW-(D10Rat194-D10Chm243)/Ayd A double congenic strain derived from the progenitor strain SS.MNS-(D2Rat155-D2Chm419)/Ayd and SS.LEW-(D10Rat194-D10Chm243)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551763 8551766 SS.MNS-(D2Rat155-D2Chm419),LEW-(D10Chm10-D10Rat11)/Ayd A double congenic strain derived from the progenitor strain SS.MNS-(D2Rat155-D2Chm419)/Ayd and SS.LEW-(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551766 8551772 SS.MNS-(D2Chm33-Tm2sf1),LEW-(D10Rat194-D10Chm243),LEW-(D10Chm10-D10Rat11)/Ayd A triple congenic strain derived from the progenitor strain SS.MNS-(D2Chm33-Tm2sf1)/Ayd and SS.LEW-(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551772 8551774 SS.MNS-(D2Chm33-Tm2sf1),LEW-(D10Chm10-D10Rat11)/Ayd A double congenic strain derived from the progenitor strain SS.MNS-(D2Chm33-Tm2sf1)/Ayd and SS.LEW-(D10Chm10-D10Rat11)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551774 8551776 SS.MNS-(D2Chm33-Tm2sf1),LEW-(D10Rat194-D10Chm243)/Ayd A double congenic strain derived from the progenitor strain SS.MNS-(D2Chm33-Tm2sf1)/Ayd and SS.LEW-(D10Rat194-D10Chm243)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551776 8551778 SS.MNS-(D2Chm33-Tm2sf1),LEW-(D3Rat2-D3Chm79)/Ayd A double congenic strain derived from the progenitor strain SS.MNS-(D2Chm33-Tm2sf1)/Ayd and SS.LEW-(D3Rat2-D3Chm79)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8551778 8551782 SS.LEW-(D18Chm90-D18Chm4)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 13071222 27421017 1 - by flanking markers 18 12230011 27443258 1 - by flanking markers 18 12441876 27733166 1 - by flanking markers 18 12710576 26538225 1 - by flanking markers RRID:RGD_8551782 8551785 SS.LEW-(D18Wox7-D18Rat67)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 12406948 23780206 1 - by flanking markers 18 15314151 23867696 1 - by flanking markers 18 15539551 24147513 1 - by flanking markers 18 11944273 23012468 1 - by flanking markers RRID:RGD_8551785 8551787 SS.LEW-(D18Rat55-D18Mgh2)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 54856551 62313296 1 - by flanking markers 18 53346348 61092546 1 - by flanking markers 18 54108375 61901354 1 - by flanking markers 18 52539763 59712417 1 - by flanking markers RRID:RGD_8551787 8551789 SS.LEW-(D18Chm59-D18Rat1)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown 18 69138888 86857890 1 - by flanking markers 18 66790645 86108580 1 - by flanking markers 18 67627706 87074531 1 - by flanking markers 18 65970331 83213037 1 - by flanking markers RRID:RGD_8551789 8551864 DA.LEW.1AV1-(D4Mgh17-D4Mgh21)/Kiru LEW.1AV1/Kini allele is introgressed into the DA/ZtmKini rats. Department of Medicine, Karolinska Institutet, Stockholm, Sweden congenic Unknown 4 116611031 116611168 1 - by flanking markers 4 177782842 177926667 1 - by flanking markers 4 113100978 179563872 1 - by flanking markers 4 114921280 114921417 1 - by flanking markers RRID:RGD_8551864 8551866 LEW.1AV1.DA-(D4Mgh17-D4Rat203)/Kiru DA/ZtmKini allele is introgressed into the LEW.1AV1/kini rats. Department of Medicine, Karolinska Institutet, Stockholm, Sweden congenic Unknown 4 116611031 161435775 1 - by flanking markers 4 177782842 224843794 1 - by flanking markers 4 113100978 157826751 1 - by flanking markers 4 114921280 158112799 1 - by flanking markers RRID:RGD_8551866 8551868 PVG.1AV1.DA-(D4Mgh17-D4Rat84)/Kiru DA/ZtmKini allele is introgressed into the PVG.1AV1/Kini rats. Department of Medicine, Karolinska Institutet, Stockholm, Sweden congenic Unknown 4 116611031 185398530 1 - by flanking markers 4 177782842 246313537 1 - by flanking markers 4 113100978 182171018 1 - by flanking markers 4 114921280 180699135 1 - by flanking markers RRID:RGD_8551868 8551872 DA.PVG.1AV1-(D4Rat155-D4Rat113)/Kiru Congenic substrain derived from marker assisted selection for PVG.1AV1/Kini chromosome 4 alleles on the DA/ZtmKini recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 157006984 157007337 1 - by flanking markers 4 47848402 220242357 1 - by flanking markers 4 48053950 153153072 1 - by flanking markers 4 49524674 153826492 1 - by flanking markers RRID:RGD_8551872 8551874 DA.PVG.1AV1-(D4Rat63-D4Rat84)/Kiru Congenic substrain derived from marker assisted selection for PVG.1AV1/Kini chromosome 4 alleles on the DA/ZtmKini recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 156442644 185398530 1 - by flanking markers 4 219683260 246313537 1 - by flanking markers 4 152598827 182171018 1 - by flanking markers 4 153274175 180699135 1 - by flanking markers RRID:RGD_8551874 8551876 DA.PVG.1AV1-(D4Rat203-D4Got130)/Kiru Congenic substrain derived from marker assisted selection for PVG.1AV1/Kini chromosome 4 alleles on the DA/ZtmKini recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 161435633 166051402 1 - by flanking markers 4 224843653 227653798 1 - by flanking markers 4 157826610 162454686 1 - by flanking markers 4 158112655 162281835 1 - by flanking markers RRID:RGD_8551876 8551880 DA.PVG.1AV1-(D4Rat63-D4Rat203)/Kiru Congenic substrain derived from marker assisted selection for PVG.1AV1/Kini chromosome 4 alleles on the DA/ZtmKini recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 156442644 161435775 1 - by flanking markers 4 219683260 224843794 1 - by flanking markers 4 152598827 157826751 1 - by flanking markers 4 153274175 158112799 1 - by flanking markers RRID:RGD_8551880 8551882 DA.PVG.1AV1-(D4Rat203-D4Mit22)/Kiru Congenic substrain derived from marker assisted selection for PVG.1AV1/Kini chromosome 4 alleles on the DA/ZtmKini recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 161435633 175947418 1 - by flanking markers 4 224843653 236764513 1 - by flanking markers 4 157826610 172512411 1 - by flanking markers 4 158112655 171728165 1 - by flanking markers RRID:RGD_8551882 8551885 DA.PVG.1AV1-(D4Mit22-D4Rat84)/Kiru Congenic substrain derived from marker assisted selection for PVG.1AV1/Kini chromosome 4 alleles on the DA/ZtmKini recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 175947270 185398530 1 - by flanking markers 4 236764366 246313537 1 - by flanking markers 4 172512264 182171018 1 - by flanking markers 4 171728017 180699135 1 - by flanking markers RRID:RGD_8551885 8551887 DA.PVG.1AV1-(D4Got126-D4Rat203)/Kiru Congenic substrain derived from marker assisted selection for PVG.1AV1/Kini chromosome 4 alleles on the DA/ZtmKini recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 159298584 161435775 1 - by flanking markers 4 222677930 224843794 1 - by flanking markers 4 155657051 157826751 1 - by flanking markers 4 156050654 158112799 1 - by flanking markers RRID:RGD_8551887 8551889 DA.PVG.1AV1-(D4Rat62-D4Got136)/Kiru Congenic substrain derived from marker assisted selection for PVG.1AV1/Kini chromosome 4 alleles on the DA/ZtmKini recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 157913800 160528447 1 - by flanking markers 4 221142142 223964695 1 - by flanking markers 4 154054175 156945571 1 - by flanking markers 4 154716992 157232313 1 - by flanking markers RRID:RGD_8551889 8551892 DA.PVG.1AV1-(D4Rat113-D4Rat62)/Kiru Congenic substrain derived from marker assisted selection for PVG.1AV1/Kini chromosome 4 alleles on the DA/ZtmKini recipient strain. Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden congenic Unknown 4 157006984 157913968 1 - by flanking markers 4 220242234 221142309 1 - by flanking markers 4 153152949 154054342 1 - by flanking markers 4 153826368 154717160 1 - by flanking markers RRID:RGD_8551892 8552235 SD-Tg(Pbsn-TAg)1Obs SV40 Large T Antigen along with Rat probasin promoter National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2017-08-17) Pbsn 708571 RRID:RGD_8552235 8552237 WI-Tg(Nanog-GFP-PuroR)22Kyo mouse Nanog-GFP IRES puromycin resistant BAC was injected into Crlj:WI rat embryos. 4 lines were established of which line 22 showed the best breeding performance National BioResource Project for the Rat in Japan transgenic Live Animals RRID:RGD_8552237 8552239 F344.WI-Tg(Nanog-GFP-PuroR)Kyo WI-Tg(Nanog-GFP-puro-R)/22Kyo rats were backcrossed to F344/Stm to transfer the transgene onto a different genetic background National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_8552239 8552242 ETR/Eis Eisai Turning Rat Developed by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo Behavior RRID:RGD_8552242 8552244 SD-Tg(Dsp-mCherry-DTR)Jfln This rat carries a transgene consisting of the Dsp promoter followed by a STOP cassette flanked by FRT sites. The stop cassette consists of an mcherry gene encoding for a red fluorescent protein and a kanamycin resistant gene and three SV40polyA adenylation signals. The STOP cassette is followed by a gene encoding for the human diphtheria toxin receptor. Red fluorescence can be detected from the skin of the animals but not the brain. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_8552244 8552247 SD-Tg(Neurod6-mCherry-DTR)Jfln This rat carries a transgene consisting of the NeuroD6 promoter followed by a STOP cassette flanked by FRT sites. The stop cassette consists of an mcherry gene encoding for a red fluorescent protein and a kanamycin resistant gene and three SV40polyA adenylation signals. The STOP cassette is followed by a gene encoding for the human diphtheria toxin receptor. This model is yet to be validated. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2017-08-17) RRID:RGD_8552247 8552249 SD-Tg(Camk2a-FLPo)Jfln This transgene consists of approximately 6kb of the CamK2a promoter followed by a gene encoding FLP, optimised for mamalian exprssion (FLPo). This rat remains unvalidated. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2017-08-16) RRID:RGD_8552249 8552252 ACI.BUF-Aftm1/2Mna This congenic strain was established as a strain with the genetic background of ACI onto which a segment from the BUF/Mna has been transferred. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo RRID:RGD_8552252 8552255 LAP/Hshyo low alcohol preference rat Developed by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo RRID:RGD_8552255 8552257 HAP/Hshyo high alcohol preference rat Developed by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo RRID:RGD_8552257 8552259 F344-Ldlrm1Kyo/Ta Developed by the DEPOSITOR National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo RRID:RGD_8552259 8552261 WIAR.MPR-Arsbabd/Ncchd Developed by the DEPOSITOR. This congenic strain was established by backcrossing MPR/Iar (RGD:2306064) (provided by Dr. Kunieda, Okayama University) to WIAR/Iar (RGD:2304222) National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2023-03-07) Osteology; Metabolism Arsb|ArsbMPR 2158|12792967 2 24067560 24223821 1 - by flanking markers 2 42559079 42717753 1 - by flanking markers 2 23385154 23543028 1 - by flanking markers 2 25002210 25162675 1 - by flanking markers RRID:RGD_8552261 8552267 SHRSP.WKY-(D1Rat116-D1Wox10)/Tkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity 1 218466863 220639653 1 - by flanking markers 1 238863547 244066407 1 - by flanking markers 1 231729437 236763528 1 - by flanking markers 1 212458494 214537671 1 - by flanking markers RRID:RGD_8552267 8552269 SHRSP.WKY-(D1Tkyo58-D1Rat90)/Tkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity 1 267110921 267111153 1 - by flanking markers 1 289137107 289137268 1 - by flanking markers 1 281795624 281795785 1 - by flanking markers 1 259647732 259647894 1 - by flanking markers RRID:RGD_8552269 8552271 SHRSP.WKY-(D1Rat27-D1Wox18)/Tkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity 1 90282040 94626661 1 - by flanking markers 1 95301716 101198506 1 - by flanking markers 1 94201400 100133395 1 - by flanking markers 1 90508614 94644553 1 - by flanking markers RRID:RGD_8552271 8552273 SHRSP.WKY-(D1Tkyo57-D1Wox18)/Tkyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity 1 94626541 94626661 1 - by flanking markers 1 101198387 101198506 1 - by flanking markers 1 100133276 100133395 1 - by flanking markers 1 94644435 94644553 1 - by flanking markers RRID:RGD_8552273 8552275 F344-Lgi1m1Kyo Developed by gene driven ENU mutagenesis in F344/NSlc rats. Lgi1-mutant rats carrying a missense mutation (c.1154 T > G)(L385R). National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2017-03-17) Lgi1|Lgi1m1Kyo 628742|12792970 1 242593236 242634141 1 - by flanking markers 1 264436441 264477332 1 - by flanking markers 1 256955944 256996835 1 - by flanking markers 1 236043376 236084270 1 - by flanking markers RRID:RGD_8552275 8552279 WI-Tg(Per1-luc)Ylab The original work using this transgenic rat was published in Science (Yamazaki et al. 2000). This transgenic rat was generated in the Wistar outbred strain (Charles River, Japan). We maintained the L1 line. The transgenic rat was generated using a DNA construct in which the mouse Period1 promoter drives firefly luciferase National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_8552279 8552285 F344.WI-Tg(Per1-luc)Ylab The original work using this transgenic rat was published in Science (Yamazaki et al. 2000). This transgenic rat was generated in the Wistar outbred strain (Charles River, Japan). We maintained the L1 line. The transgenic rat was generated using a DNA construct in which the mouse Period1 promoter drives firefly luciferase National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_8552285 8552287 F344.WIC-TgrdwKts This is a F344 congenic carrying Tgrdw derived from WIC-Tgrdw/Kts. WIC-Tgrdw/Kts was established from a closed colony of Wistar-Imamichi (WIC) rats as a spontaneous mutant exhibiting congenital dwarfism (rdw), is inherited as an autosomal recessive. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2017-04-27) Metabolism RRID:RGD_8552287 8552289 A5M/Khos Developed by the DEPOSITOR National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo Metabolism RRID:RGD_8552289 8552293 SR/JrSeac Dahl Salt-Resistant Substrain of Dahl SR, from a Sprague-Dawley outbred colony, selected for resistance to salt-induced hypertension developed at Kyudo Co.,Ltd (http://www.kyudo.co.jp/) to Seac Yoshitomi, LTD Japan, now maintained at NBRP National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio- Hypertension RRID:RGD_8552293 8552296 UPL/CasTakeu Substrain of UPL National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo Ophthalmology RRID:RGD_8552296 8552298 DA-Tyrem1Kyo The strain having a Endonuclease-induced 29-bp deletion mutation in Tyr gene was established by TALENs combined with Exonuclease 1. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2017-03-17) Behavior; Dermatology Tyr|Tyrem1Kyo 1589755|12792972 1 143641257 143746315 1 - by flanking markers 1 157322968 157416594 1 - by flanking markers 1 151012598 151106802 1 - by flanking markers 1 141115036 141210207 1 - by flanking markers RRID:RGD_8552298 8552303 DA-Tyrem2Kyo Developed by the DEPOSITOR National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm Behavior; Dermatology RRID:RGD_8552303 8552309 ODUS/Odu The mutant rat showing spontaneous gingivitis was found in the colony of WKY rats in 1972. The inbred strain was established in 1991. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo RRID:RGD_8552309 8552311 ODUR/Odu This inbred strain was established from WKY rats as a control for ODUS/Odu. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo RRID:RGD_8552311 8552313 DA.PVG.1AV1-(D10Rat81-D10Rat238)/Kini DA/Kini females were bred to PVG.1AV1/Kini males and male offspring selected for PVG alleles within the fragment. To ensure that mitochondrial DNA was inherited from the DA/Kini strain, female rats were from the DA/Kini strain throughout the breeding program. Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 10 49618846 62685691 1 - by flanking markers 10 49641148 61927099 1 - by flanking markers 10 49863561 62214000 1 - by flanking markers 10 48075363 60222446 1 - by flanking markers RRID:RGD_8552313 8552315 W-Tg(Thy1-COP4/YFP*)4Jfhy The transgenic rats were established by injection of transgene consisting of ChR2 and Venus fused transgene driven by the Thy-1.2 promoter into Wistar rat fertile eggs. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Ophthalmology; Otorhinology RRID:RGD_8552315 8552317 W-Tg(Thy1-COP4/YFP*)5Jfhy The transgenic rats were established by injection of transgene consisting of ChR2 and Venus fused transgene driven by the Thy-1.2 promoter into Wistar rat fertile eggs. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Ophthalmology; Otorhinology RRID:RGD_8552317 8552319 W-Tg(Thy1-COP4/YFP*)6Jfhy The transgenic rats were established by injection of transgene consisting of ChR2 and Venus fused transgene driven by the Thy-1.2 promoter into Wistar rat fertile eggs. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Ophthalmology; Otorhinology RRID:RGD_8552319 8552321 SHR-Tg(APOC3-CETP)1Tkyo The transgenic rats were established by injection of transgene consisting of cholesterylester tansfer protein gene driven by the APOC3 promoter into SHR/Izm rat fertile eggs. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Diabetes Obesity; Neurobiology RRID:RGD_8552321 8552323 SHR-Tg(APOC3-CETP)2Tkyo The transgenic rats were established by injection of transgene consisting of cholesterylester tansfer protein gene driven by the APOC4 promoter into SHR/Izm rat fertile eggs. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Diabetes Obesity; Neurobiology RRID:RGD_8552323 8552325 SHR-Tg(APOC3-CETP)3Tkyo The transgenic rats were established by injection of transgene consisting of cholesterylester tansfer protein gene driven by the APOC5 promoter into SHR/Izm rat fertile eggs. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Diabetes Obesity; Neurobiology RRID:RGD_8552325 8552327 SHR-Tg(APOC3-CETP)4Tkyo The transgenic rats were established by injection of transgene consisting of cholesterylester tansfer protein gene driven by the APOC4 promoter into SHR/Izm rat fertile eggs. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Diabetes Obesity; Neurobiology RRID:RGD_8552327 8552329 W-Tg(Nqo1)Kop The transgenic rats were established by injection of transgene consisting of NAD(P)H quinone oxidoreductase 1 gene derived from a DA/Slc rat strain into Wistar rat fertile eggs. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Oncology; Metabolism RRID:RGD_8552329 8552331 F344-Il2rgem7Kyo The strain having a Endonuclease-induced 7 bp deletion mutation in the 2nd exon of the rat Il2rg gene was established by TAL effector nuclease obtained from Dr. Yamamoto at Hiroshima University. National BioResource Project for the Rat in Japan mutant Unknown Hematology; Immunology Il2rgem7Kyo 13628732 X 89342055 89345715 1 - by flanking markers X 72017856 72021516 1 - by flanking markers X 71165378 71169078 1 - by flanking markers X 66395330 66399026 1 - by flanking markers RRID:RGD_8552331 8552337 DA.PVG.1AV1-(D10Got406-D10Rat93)/Kini Inbred Dark Agouti (DA) rats were originally obtained from Hannover, Germany and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). Animals for congenic breeding were selected from the 10th generation of an advanced intercross line (AIL) originating from the EAE-susceptible DA and EAE-resistant PVG.1AV1 rat strains. Selected males containing a PVG.1AV1 fragment in the Eae18b region (from OT24.18 to D10Rat93 marker, at 68.36 Mb and 81.9 Mb, respectively) were backcrossed with DA females for 8 generations, and offspring was genotyped using microsatellite markers in each generation. In the 8th generation, heterozygous males and females were crossed to obtain the experimental population of homozygous congenic rats and littermate controls. Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 10 68361384 81887390 1 - by flanking markers 10 67154600 80788180 1 - by flanking markers 10 67495867 80946110 1 - by flanking markers 10 65139038 78210622 1 - by flanking markers RRID:RGD_8552337 8552341 DA.PVG.1AV1-(D10Got6-D10Rat184)/Kini Inbred Dark Agouti (DA) rats were originally obtained from Hannover, Germany and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). Congenic strain was established by transfer of the defined Vra4 segment selected from male donors of G8 generation of a DAxPVG1.AV1 andvanced intercross line. Subsequential backcrossing for 9 generations. Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 10 3219701 11568211 1 - by flanking markers 10 1728277 10319475 1 - by flanking markers 10 2847625 11561989 1 - by flanking markers 10 3406320 3406594 1 - by flanking markers RRID:RGD_8552341 8552346 DA.PVG.1AV1-(D4Rat107-D4Got132)/Kini Inbred Dark Agouti (DA) rats were originally obtained from Hannover, Germany and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). Congenic strain was established by selective transferring of PVG alleles in the interval between D4Rat137 and D4Kiru157 onto DA background in minimum of 13 backcross generations. Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 4 156090003 162362144 1 - by flanking markers 4 219336960 225566369 1 - by flanking markers 4 152249616 158564471 1 - by flanking markers 4 152925326 158841762 1 - by flanking markers RRID:RGD_8552346 8552348 DA.PVG.1AV1-(D13Rat105-D13Rat131)/Kini Inbred Dark Agouti (DA) rats were originally obtained from Hannover, Germany and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). The congenic line was established from DA and MHC-identical PVG.A rats using a speed-congenic approach with marker assisted selection. DA females were mated with male offspring selected from F2 (DAxPVG.A) with heterozygote alleles within chromosome 13 and Eae34 QTL interval and with the lowest PVG.A background contamination using 96 microsatellite markers equally spaced throughout the genome (at 20 centimorgan cM intervals). A breeding pair selected from the N7 generation were crossed for two generations to produce homozygous DA.PVG-Eae34 congenic rats. Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 13 45592985 80755583 1 - by flanking markers 13 54552997 88144258 1 - by flanking markers 13 49478067 83263907 1 - by flanking markers 13 44139595 77313088 1 - by flanking markers RRID:RGD_8552348 8552351 DA.PVG.1AV1-(D9Wox24-D9Rat44)/Kini Inbred Dark Agouti (DA) rats were originally obtained from Hannover, Germany and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). Briefly, in each backcross generation, rats for further breeding were selected on the basis of genotyping of 8 microsatellite markers in the congenic region, from marker D9Wox24 to D9Rat20. The genetic background of rats was also screened with 100 markers. After the complete removal of the donor genome outside the congenic fragment, two heterozygous rats were intercrossed to produce the homozygous strains DA.BN-Eae4(N7F1). Subsequently, interval-specific recombinants were bred from an F2 breeding. R25 recombinant was established in 2003. Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 9 2948882 2949051 1 - by flanking markers 9 2813697 9858600 1 - by flanking markers 9 2880977 10869489 1 - by flanking markers 9 1024537 5109995 1 - by flanking markers RRID:RGD_8552351 8552364 WI-Tg(L2-Venus)Nips The construct contains CAG--lox P--Neo-pA--lox P--Venus--pA (4.3 kb) which was injected into Crlj:WI embryos; now maintained as transgenic heterozygotes Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN transgenic Unknown RRID:RGD_8552364 8552366 WI-Tg(CAG-cre)Nips The construct contains CAG--NLS-Cre--pA (3.3 kb)which was injected into Crlj:WI embryos; now maintained as transgenic heterozygotes Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN transgenic Unknown RRID:RGD_8552366 8552368 WI-Tg(CAG-Venus)Nips The construct contains L2-Venus ÿ CAG-Cre (CAG--lox P--Venus--pA (3.1 kb)) which was injected into Crlj:WI embryos; now maintained as transgenic heterozygotes Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN transgenic Unknown RRID:RGD_8552368 8552371 WDB-ROSA26em1(RT2)Nips This strain was produced by knock-in in the rat Rosa26 locus using the construct 5' arm--tdTomato--IRES-Puro^r-pA--3' arm (11 kb) to the WDB/Nips strain. Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN mutant Unknown RRID:RGD_8552371 8552996 F344/Arc substrain of F344 bred at Animal Resources Centre Australia Animal Resources Centre, Australia inbred Unknown RRID:RGD_8552996 8553001 ArcCrl:CD(SD) substrain derived from Crl:CD(SD); IGS refers to animals bred using the CRL International Genetic Standard system. Animal Resources Centre, Australia outbred Unknown RRID:RGD_8553001 8553003 ArcCrl:WI Wistar rats From Charles River to Animal Resources Centre, Australia Animal Resources Centre, Australia outbred Unknown RRID:RGD_8553003 8553005 BN/RijHsdArc To Animal Resources Centre, Australia from Harlan. Animal Resources Centre, Australia inbred Unknown RRID:RGD_8553005 8553006 DA/Arc substrain of DA bred at Animal Resources Centre, Australia Animal Resources Centre, Australia inbred Unknown RRID:RGD_8553006 8553008 LEW/CrlArc Lewis Developed by Dr. Lewis from Wistar stock in the early 1950s. To Animal Resources Centre, Australia from Charles River Animal Resources Centre, Australia inbred Unknown RRID:RGD_8553008 8553010 PVG/Arc substrain of PVG maintained at Animal Resources Centre Animal Resources Centre, Australia inbred Unknown RRID:RGD_8553010 8553013 SHR/NCrlArc To Animal Resources Centre from Charles River Animal Resources Centre, Australia inbred Unknown RRID:RGD_8553013 8553015 WKY/NCrlArc To Animal Resources Centre from Charles River Animal Resources Centre, Australia inbred Unknown RRID:RGD_8553015 8553187 FHH.BN(D14Rat98-D14Hmgc4)/Mcwi desired segments from BN were introgressed in FHH background Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 14 14535071 21435476 1 - by flanking markers 14 14613528 21463742 1 - by flanking markers 14 14673206 21555302 1 - by flanking markers 14 13015311 19848266 1 - by flanking markers RRID:RGD_8553187 8655639 WAG/Nov Substrain of WAG, now bred at the Institute of Cytology and Genetics, Russian Academy of Sciences (Novosibirsk) Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia inbred Unknown RRID:RGD_8655639 8655660 WAG.OXYS-(D1Rat30-D1Rat219)/Nov desired region was introgressed from OXYS/Nov into the genetic background of WAG/Nov by first intercrossing and then backcrossing to WAG/Nov Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia congenic Unknown Cic|Arhgap33 1310706|2318374 1 100539980 188654926 1 - by flanking markers 1 107049754 209588735 1 - by flanking markers 1 106002252 202571904 1 - by flanking markers 1 100357752 183970443 1 - by flanking markers RRID:RGD_8655660 8655663 WAG.OXYS-(D1Rat219-D1Rat81)/Nov desired region was introgressed from OXYS/Nov into the genetic background of WAG/Nov by first intercrossing and then backcrossing to WAG/Nov Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia congenic Unknown Snurf|Ifit1|Zp2|Gtf3c1|Col17a1 69269|620599|620605|621048|1311130 1 188654686 250119874 1 - by flanking markers 1 209588496 272245383 1 - by flanking markers 1 202571665 264802994 1 - by flanking markers 1 183970203 243914901 1 - by flanking markers RRID:RGD_8655663 8655977 W-Lepr+/+/Nin Wistar NIN lean The lean litter mates of WNIN-Ob (W-LeprfaNin, RGD:8655992). Both are derived from the inbred stock of Wistar rats (W/NIN) dating back to 1920 at National Institute of Nutrition (NIN), Hyderabad, India. National Institute of Nutrition (NIN), Hyderabad, India inbred Unknown RRID:RGD_8655977 8655992 W-LeprfaNin The spontaneously developed obese rat was derived from the colony of inbred W/Nin by selective breeding. Its lean litter mate ( W-Lepr+/+/Nin, RGD:8655977) was used as a control strain in obesity related study. National Institute of Nutrition (NIN), Hyderabad, India mutant Unknown RRID:RGD_8655992 8657051 F344/Nin Substrain of F344 maintained at National Institute of Nutrition (NIN), Hyderabad, India. National Institute of Nutrition (NIN), Hyderabad, India inbred Unknown RRID:RGD_8657051 8657079 SS.LEW-(D18Chm124-D18Chm126)/Ayd SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre-CHUM, Montreal, Quebec, Canada congenic Unknown RRID:RGD_8657079 8657135 SS.LEW-(D10Chm280-D10Chm216)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Chm224-D10Chm6)/Ayd Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown 10 76589831 76590030 1 - by flanking markers 10 74503802 74504001 1 - by flanking markers 10 75603400 75603599 1 - by flanking markers 10 73073387 73073589 1 - by flanking markers RRID:RGD_8657135 8657348 SS.LEW-(D17Chm131-D17Chm93),MNS-(D2Rat155-D2Chm161),LEW-(D18Chm41-D18Rat92)/Ayd A triple congenic strain derived from the progenitor strain SS.LEW-(D17Chm31-D17Chm93)/Ayd, SS.MNS-(D2Rat155-D2Chm161)/Ayd and SS.LEW-(D18Chm41-D18Rat92)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8657348 8657351 SS.MNS-(D2Chm366-D2Rat52),LEW-(D18Rat61-D18Rat45),LEW-(D10Chm128-D10Chm121)/Ayd A triple congenic strain derived from the progenitor strain SS.MNS-(D2Chm366-D2Rat52)/Ayd, SS.LEW-(D18Rat61-D18Rat45)/Ayd and SS.LEW-(D10Chm128-D10Chm121)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8657351 8657361 SS.MNS-(D2Chm254-D2Chm161),LEW-(D10Chm246-D10Chm257),LEW-(D16Chm48-D16Chm60),LEW-(D18Rat55-D18Mgh2)/Ayd A congenic strain derived from the progenitor strain SS.MNS-(D2Chm254-D2Chm161)/Ayd, SS.LEW-(D10Chm246-D10Chm257)/Ayd and SS.LEW-(D16Chm48-D16Chm60)/Ayd and SS.LEW-(D18Rat55-D18Mgh2)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8657361 8657392 SS.LEW-(D10Rat155-D10Chm171)/Ayd A sub congenic strain derived from the progenitor strain SS.LEW-(D10Chm224-D10Chm6)/Ayd. Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown 10 70229781 71032765 1 - by flanking markers 10 69020437 69797898 1 - by flanking markers 10 69385595 70167191 1 - by flanking markers 10 66978955 67750281 1 - by flanking markers RRID:RGD_8657392 8657399 SS.MNS-(D2Chm214-D2Chm302)/Ayd Congenic substrain created by backcrossing congenic strain MNS/N strain with Dahl Salt-sensitive (SS/Jr) strain, the F2 rats were genotyped with markers that resided in the region of interest, heterozygous rat was then backcrossed to SS/Jr rat to duplicate the fragment. Centre Hospitalier de Universite de Montreal (CRCHUM), Quebec, Canada congenic Unknown RRID:RGD_8657399 8657402 SS.LEW-(D3Rat52-D3Chm57),MNS-(D2Chm214-D2Chm302),LEW-(D10Rat194-D10Chm243)/Ayd A triple congenic strain derived from the progenitor strain SS.LEW-(D3Rat52-D3Chm57)/Ayd, SS.MNS-(D2Chm214-D2Chm302)/Ayd and SS.LEW-(D10Rat194-D10Chm243)/Ayd Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada congenic Unknown RRID:RGD_8657402 8661233 SS-TgTn(T2GFP)53Mcwi This strain was made by pronuclear microinjection of SS/JrHsdMcwi embryos with a Sleeping Beauty transposon vector harboring a ubiquitous CAG promoter driving enhanced green fluorescent protein along with mRNA encoding the SB100X transposase. The transposon inserted into rat chromosome 15 near 35.6 Mb (rn4) Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_8661233 8661234 SS-TgTn(T2ePet-eGFP)11Mcwi This strain was made by pronuclear microinjection of SS/JrHsdMcwi embryos with a Sleeping Beauty transposon vector harboring a serotonergic neuron-specific ePet1 promoter driving enhanced green fluorescent protein along with mRNA encoding the SB100X transposase. The transposon inserted into rat chromosome 7 near 123.8Mb (rn4) Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown RRID:RGD_8661234 8661235 FHH-TgTn(T2/Rab38)1Mcwi This strain was made by pronuclear microinjection of a Sleeping Beauty transposon vector harboring a ubiquitous CAG promoter driving the Brown Norway allele cDNA for Rab38 along with mRNA encoding the SB100X transposase. The transposon inserted into rat chromosome 14 near 13.2 Mb (rn4) Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin transgenic Unknown Rab38 628752 RRID:RGD_8661235 8662449 LOU/MBbb LOU/M strain maintained at Max-Delbruck-Center for Molecular Medicine, Berlin, Germany Max-Delbruck-Center for Molecular Medicine, Berlin, Germany inbred Unknown RRID:RGD_8662449 8662861 LOU.BN-(D5Rat59-D5Rat133)/Bbb the desired chromosomal segment from BN/Rj was introgressed into the genetic background of LOU/MBbb Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown 5 1368223 49696253 1 - by flanking markers 5 1662934 53233338 1 - by flanking markers 5 1666587 48652920 1 - by flanking markers 5 2282226 47798053 1 - by flanking markers RRID:RGD_8662861 8662874 LOU.BN-(D5Rat59-D5Rat127)/Bbb this congenic strain is produced by backcrossing LOU.BN-(D5Rat59-D5Rat133)/Bbb to LOU/MBbb Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown 5 1368223 27586431 1 - by flanking markers 5 1662934 31408200 1 - by flanking markers 5 1666587 26713119 1 - by flanking markers 5 2282226 26607972 1 - by flanking markers RRID:RGD_8662874 8662878 LOU.BN-(D5Rat59-D5Rat125)/Bbb this congenic strain is produced by backcrossing LOU.BN-(D5Rat59-D5Rat133)/Bbb to LOU/MBbb Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown 5 1368223 17703194 1 - by flanking markers 5 1662934 22043910 1 - by flanking markers 5 1666587 17263178 1 - by flanking markers 5 2282226 17397969 1 - by flanking markers RRID:RGD_8662878 8662925 LOU.BN-(D5Rat59-rs13448399)/Bbb this congenic strain is produced by backcrossing LOU.BN-(D5Rat59-D5Rat133)/Bbb to LOU/MBbb Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown 5 1368223 5230907 1 - by flanking markers 5 1662934 10489561 1 - by flanking markers 5 1666587 5649731 1 - by flanking markers 5 2282226 2282446 1 - by flanking markers RRID:RGD_8662925 8662933 LOU.BN-(rs65016308-D5Rat133)/Bbb this congenic strain is produced by backcrossing LOU.BN-(D5Rat59-D5Rat133)/Bbb to LOU/MBbb Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown 5 10525723 49696253 1 - by flanking markers 5 15442246 53233338 1 - by flanking markers 5 10652699 48652920 1 - by flanking markers 5 47797856 47798053 1 - by flanking markers RRID:RGD_8662933 8662955 LOU.BN-(rs13448399-D5Rat133)/Bbb this congenic strain is produced by backcrossing LOU.BN-(D5Rat59-D5Rat133)/Bbb to LOU/MBbb Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown 5 5230907 49696253 1 - by flanking markers 5 10489561 53233338 1 - by flanking markers 5 5649731 48652920 1 - by flanking markers 5 47797856 47798053 1 - by flanking markers RRID:RGD_8662955 8662958 LOU.BN-(D5Rat59-rs13448399)/Bbb-/+ this heterozygous congenic strain is produced by backcrossing LOU.BN-(D5Rat59-D5Rat133)/Bbb to LOU/MBbb Max-Delbruck-Center for Molecular Medicine, Berlin, Germany congenic Unknown 5 1368223 5230907 1 - by flanking markers 5 1662934 10489561 1 - by flanking markers 5 1666587 5649731 1 - by flanking markers 5 2282226 2282446 1 - by flanking markers RRID:RGD_8662958 8663453 BN.ACI-(D14Uwm4-D14Rat39)/Shul This congenic strain contains a region of ACI/SegHsd chromosome 14 transferred to the BN/SsNHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 14 77787938 77788272 1 - by flanking markers 14 77221247 77221492 1 - by flanking markers 14 34997325 77240029 1 - by flanking markers 14 32471902 72508789 1 - by flanking markers RRID:RGD_8663453 8663455 BN.ACI-(D14Uwm1-D14Uwm5)/Shul This congenic strain contains a region of ACI/SegHsd chromosome 14 transferred to the BN/SsNHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown 14 34228109 36047474 1 - by flanking markers 14 31707011 33514760 1 - by flanking markers RRID:RGD_8663455 8663458 ACI.BN-(D7Rat164-D7Rat142)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Cryopreserved Sperm (as of 2017-09-07) mammary cancer 7 69506936 76323874 1 - by flanking markers 7 72918736 79648829 1 - by flanking markers 7 72752037 79629245 1 - by flanking markers 7 65287247 71789091 1 - by flanking markers RRID:RGD_8663458 8663462 ACI.BN-(D7Uwm32-D7Uwm43)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Cryopreserved Sperm (as of 2017-09-07) mammary cancer 7 0 0 1 - by flanking markers RRID:RGD_8663462 8663464 ACI.BN-(D7Uwm33-D7Uwm43)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Live Animals (as of 2017-09-07) mammary cancer 7 0 0 1 - by flanking markers RRID:RGD_8663464 8693598 LE-Tg(DIO-mCherry)2OttcRrrc The transgene contains Cre recombinase reporter rat expressing mCherry driven by the EF1 alpha promoter. Rat Resource and Research Center transgenic Cryopreserved Sperm; Cryorecovery RRID:RRRC_00687 9586448 SHR/NCrlPrin Substrain of SHR originally from Charles River now maintained at University of California Dept. of Pharmacology, University of California, San Diego, La Jolla, California inbred Unknown RRID:RGD_9586448 9586450 SHR/OlaIpcvPrin These are substrains of SHR from Czech Academy of Sciences now maintained at University of California Dept. of Pharmacology, University of California, San Diego, La Jolla, California inbred Unknown RRID:RGD_9586450 9587464 SD-Tg(UBC-DsRedT3-emGFP)18Narl SD-Tg(UBC-DsRedT3-emGFP)18 This strain was generated by microinjection of SD embyos with UBC-DsRed-emGFP transgene which is composed of DsRed flanked by loxP and followed by emerald GFP(emGFP). The transgene is driven by human UBC promoter. National Laboratory Animal Center, Taiwan transgenic Live Animals UBC 1346853 RRID:RGD_9587464 9587466 SD-Tg(UBC-cre/ERT2)7Narl This strain was generated by microinjection of SD embyos with UBC-Cre/ERT2 transgene which is composed of Cre/ERT2 recombinase gene driven by human UBC promoter. National Laboratory Animal Center, Taiwan transgenic Cryopreserved Embryo (as of 2017-05-31) UBC 1346853 RRID:RGD_9587466 9587470 SD-Tg(UBC-DsRedT3-emGFP)26Narl This strain was generated by microinjection of SD embyos with UBC-DsRed-emGFP transgene which is composed of DsRed flanked by loxP and followed by emerald GFP(emGFP). The transgene is driven by human UBC promoter. National Laboratory Animal Center, Taiwan transgenic Cryopreserved Embryo UBC 1346853 RRID:RGD_9587470 9587473 SD-Tg(UBC-emGFP)18Narl This strain was produced by microinjection of UBC-cre construct into embryos from SD-Tg(UBC-DsRedT3-emGFP)18Narl National Laboratory Animal Center, Taiwan transgenic Live Animals UBC 1346853 RRID:RGD_9587473 9587475 SD-Tg(UBC-DsRed-GFP)(Col1a(5A)-cre)Narl This strain was produced by microinjection of Col1a(5A)-Cre construct into embryos from SD-Tg(UBC-DsRedT3-emGFP)26Narl. As loxP-flanked DsRed is removed by Col1a(5A) promoter-driven Cre recombinase National Laboratory Animal Center, Taiwan transgenic Unknown RRID:RGD_9587475 9587825 BN/SsNNarl Imported from NIH, now maintained at National Laboratory Animal Center, Taiwan National Laboratory Animal Center, Taiwan inbred Live Animals (as of 2018-03-28) RRID:RGD_9587825 9587827 F344/NNarl Imported from NIH, now maintained at National Laboratory Animal Center, Taiwan National Laboratory Animal Center, Taiwan inbred Live Animals (as of 2018-03-28) RRID:RGD_9587827 9587829 LEW/SsNNarl Imported from NIH in 1995, now maintained at National Laboratory Animal Center, Taiwan National Laboratory Animal Center, Taiwan inbred Live Animals (as of 2018-03-28) RRID:RGD_9587829 9587831 SHR/NCrlNarl Imported from NIH in 2000, now maintained at National Laboratory Animal Center, Taiwan National Laboratory Animal Center, Taiwan inbred Live Animals (as of 2018-03-28) RRID:RGD_9587831 9587833 WKY/NCrlNarl Imported from NIH in 2000, now maintained at National Laboratory Animal Center, Taiwan National Laboratory Animal Center, Taiwan inbred Live Animals (as of 2018-03-28) RRID:RGD_9587833 9587835 CrlNarl:LE Imported from Charles River in 1997, now maintained at National Laboratory Animal Center, Taiwan National Laboratory Animal Center, Taiwan outbred Live Animals (as of 2018-03-28) RRID:RGD_9587835 9588294 CrljKwl:SD Sprague-Dawley from Charles River Laboratory Japan, to Kiwa Laboratory Animals Co.Ltd. Japan in 1985; these were turned into SPF by caesarean section Kiwa Laboratory Animals Co., Ltd. Japan outbred Unknown RRID:RGD_9588294 9588298 Kwl:LE Long Evans from Sasaki Institute, Japan, to Kiwa Laboratory Animals Co.Ltd. Japan in 1971; these were turned into SPF by caesarean section Kiwa Laboratory Animals Co.Ltd. Japan outbred Unknown RRID:RGD_9588298 9588544 SHR-Ndufc2em1Mcwi This strain was produced by injecting ZFNs targeting the sequence GGCTTCCTGGGCTACTGCacgggcCTGATGGACAACATG into SHR/NCrl rat embryos. The resulting mutation is a 9-bp deletion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ndufc2em1Mcwi 9588537 1 154635889 154642112 1 - by flanking markers 1 168576274 168582497 1 - by flanking markers 1 162369801 162376024 1 - by flanking markers 1 151711965 151718188 1 - by flanking markers RRID:RGD_9588544 9588546 SHR-Ndufc2em2Mcwi This strain was produced by injecting ZFNs targeting the sequence GGCTTCCTGGGCTACTGCacgggcCTGATGGACAACATG into SHR/NCrl rat embryos. The resulting mutation is a net 107-bp deltion in exon 1. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-01-26) Ndufc2em2Mcwi 9588541 1 154635889 154642112 1 - by flanking markers 1 168576274 168582497 1 - by flanking markers 1 162369801 162376024 1 - by flanking markers 1 151711965 151718188 1 - by flanking markers RRID:RGD_9588546 9588552 SD-Nfe2l2em1Mcwi This strain was produced by injecting TALENs targeting the sequence TAGTCCTGGCGGTGGCAATTCCAAGTCCATCATGCTGAGGGCGGACGCTGCGCTA into Crl:SD Sprague Dawley rat embryos. The resulting mutation is a 41-bp deletion in exon 1. PhysGen Knockouts mutant Live Animals (as of 2017-01-26) Nfe2l2em1Mcwi 9588549 3 58366693 58394116 1 - by flanking markers 3 69041641 69069190 1 - by flanking markers 3 62497568 62525146 1 - by flanking markers 3 60594239 60621785 1 - by flanking markers RRID:RGD_9588552 9588559 LE-Tg(DIO-iRFP)3Ottc The transgene contains Cre recombinase reporter rat expressing the red fluorescent protein gene (iRFP) driven by the EF1 alpha promoter. Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Cryopreserved Sperm; Cryorecovery RRID:RRRC_00747 9588570 LE-Tg(cFos-eGFP)2Ottc The transgene contains reporter rat expressing eGFP in cFos expressing cells Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Unknown RRID:RRRC_00766 9588572 LE-Tg(Slc6a3-icre)1Ottc The transgene contains BAC transgenic using rat DAT promoter to express Cre recombinase in dopaminergic neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Unknown dopamine neurons in drug abuse or neurodegeneration RRID:RRRC_00730 9588576 LE-Tg(Slc6a3-icre)5Ottc The transgene contains BAC transgenic using rat DAT promoter to express Cre recombinase in dopaminergic neurons Optogenetics and Transgenic Technology Core transgenic Unknown RRID:RGD_9588576 9588578 LE-Tg(Slc6a3-icre)6Ottc The transgene contains BAC transgenic using rat dopamine transporterSlc6a3 (DAT) promoter to express Cre recombinase in dopaminergic neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Live Animals (as of 2017-05-31) neurodegeneration RRID:RRRC_00758 9588581 LE-Tg(cFos-LacZ)1Ottc The transgene contains reporter rat expressing beta-galactosidase in cFos expressing cells Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Unknown RRID:RRRC_00759 9588583 LE-Tg(cFos-TetO-iCre)4Ottc The transgene contains Cre recombinase expressed from cFos promoter and controllable by Tet activator/repressor Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Unknown RRID:RRRC_00760 9588585 LE-Tg(cFos-TetO-iCre)6Ottc The transgene contains Cre recombinase expressed from cFos promoter and controllable by Tet activator/repressor Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Unknown RRID:RRRC_00736 9588587 LE-Tg(EF1a-TetR)1Ottc The transgene expresses TetR using "ubiquitous" promoter; to be used in combination with TetO containing rats or viral vectors Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Unknown RRID:RRRC_00761 9588589 LE-Tg(EF1a-TetR)2Ottc The transgene expresses TetR using "ubiquitous" promoter; to be used in combination with TetO containing rats or viral vectors Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Unknown RRID:RRRC_00735 9588591 LE-Tg(Gad1-iCre)2Ottc The transgene expresses BAC transgenic using rat GAD1 promoter to express Cre recombinase in GABAergic neurons Optogenetics and Transgenic Technology Core transgenic Extinct (as of 2019-02-01) RRID:RGD_9588591 9588593 LE-Tg(Gad1-icre)3Ottc The transgene expresses BAC transgenic using rat GAD1 promoter to express Cre recombinase in GABAergic neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Live Animals (as of 2019-02-28) RRID:RRRC_00751 9588595 LE-Tg(Slc6a5-icre)1Ottc The transgene expresses BAC transgenic using rat GlyT2 promoter to express Cre recombinase in glycinergic neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Unknown RRID:RRRC_00750 9589088 ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul This congenic strain contains regions of COP/CrCrl chromosome 3 and COP/CrCrl chromosome 6 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Rat Resource and Research Center congenic Cryorecovery (as of 2019-02-26) RRID:RRRC_00743 9590284 SS-Tg(ApoC3-CETP)25Opaz SS/JrHsd embryos were microinjected with 1.57 kb human CETP cDNA construct into pSV-SPORT1 with human ApoC3 promoter Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2019-02-05) RRID:RRRC_00637 9685623 SD-Pax6Sey2/Mce This rat (developed spontaneous microphthalmia) was found in a SD rat colony at Yamanouchi Pharma Inc. (Astellas Pharma Inc.)Genomic DNA analysis from mutants revealed a single base(c) insertion, resulting in a abnormal stop codon at 33-bp downstream from the insertion site due to frameshift. Department of Ophthalmology, Okayama University Medical School, Okayama, Japan, National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2017-02-23) Pax6Sey2 12790970 3 91127605 91149178 1 - by flanking markers 3 102320059 102348223 1 - by flanking markers 3 95700241 95728682 1 - by flanking markers 3 92128772 92157022 1 - by flanking markers RRID:RGD_9685623 9685625 F344-Il2rgem1Kyo The strain having a zinc finger nuclease-induced 660-bp deletion mutation in Il2rg gene shows severe combined immunodeficiency and grows normally under SPF condition. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2017-03-27) Immunology Il2rgem1Kyo 12798560 X 89342055 89345715 1 - by flanking markers X 72017856 72021516 1 - by flanking markers X 71165378 71169078 1 - by flanking markers X 66395330 66399026 1 - by flanking markers RRID:RGD_9685625 9685748 F344-Il2rgem2Kyo The severe combined immunodeficiency strain carries a zinc finger induced 1097-bp deletion mutation of Il2rg gene created in the F344/Stm embryos. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-03-27) Immunology Il2rgem2Kyo 12798561 X 89342055 89345715 1 - by flanking markers X 72017856 72021516 1 - by flanking markers X 71165378 71169078 1 - by flanking markers X 66395330 66399026 1 - by flanking markers RRID:RGD_9685748 9685750 F344-Il2rgem3Kyo This strain shows severe combined immunodeficiency caused by a 332 bp deletion in Il2rg gene and grow normally under SPF condition. National BioResource Project for the Rat in Japan mutant Unknown Immunology Il2rgem3Kyo 13464340 X 89342055 89345715 1 - by flanking markers X 72017856 72021516 1 - by flanking markers X 71165378 71169078 1 - by flanking markers X 66395330 66399026 1 - by flanking markers RRID:RGD_9685750 9685752 TM-Il2rgem4Kyo The severe combined immunodeficiency strain carries a zinc finger nuclease-induced 162-bp deletion mutation in rat Il2rg gene. Grows normally under SPF condition. National BioResource Project for the Rat in Japan mutant Unknown Immunology Il2rgem4Kyo 13464339 X 89342055 89345715 1 - by flanking markers X 72017856 72021516 1 - by flanking markers X 71165378 71169078 1 - by flanking markers X 66395330 66399026 1 - by flanking markers RRID:RGD_9685752 9685754 TM-Il2rgem5Kyo This strain shows severe combined immunodeficiency caused by a zinc finger nuclease induced 653-bp deletion in Il2rg gene of TM/Kyo embryo. The rats grow normally under SPF condition. National BioResource Project for the Rat in Japan mutant Unknown Immunology Il2rgem5Kyo 12910099 X 89342055 89345715 1 - by flanking markers X 72017856 72021516 1 - by flanking markers X 71165378 71169078 1 - by flanking markers X 66395330 66399026 1 - by flanking markers RRID:RGD_9685754 9685755 W-Tg(tetO-Pou5f1,-Klf4,-Sox2,Ubc-rtTA,-EGFP)T1-3Hina Doxycycline induced mouse Oct3/4, Klf4, Sox2/ Ubc-promoter EGFP was introduced into embryonic fibroblast of Wistar rat (Slc:Wistar)by replication incompetent type lentivirus vector and iPS cells were induced. Chimeric rats (male) were generated from this iPS cells, and crossed with the wild-type Wistar rat (female). National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Development RRID:RGD_9685755 9685757 W-Il2rgem1Hina This strain was generated by electroporation method: introduction of Il2rg gene-targeting vector (PKG promoter-HSV TK, loxp Tk2 promoter-Neor loxp) into ES cells of Wistar rat(Crlj:Wistar) National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2017-03-27) Immunology Il2rgem1Hina 12798562 X 89342055 89345715 1 - by flanking markers X 72017856 72021516 1 - by flanking markers X 71165378 71169078 1 - by flanking markers X 66395330 66399026 1 - by flanking markers RRID:RGD_9685757 9685759 LEW.WKY-(D13Arb15-D13Rat77)(D16Rat40-D16Rat88)/Tja Segment of interest from chr 13 and chr 16 of WKY/NCrl were introgressed into LEW/SsNHsd Imperial College, London, UK, National BioResource Project for the Rat in Japan, Rat Resource and Research Center congenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26) 16;13 819225;63175274 60432230;96441728 1 - by flanking markers;1 - by flanking markers 16;13 1534408;71047218 59992088;103987907 1 - by flanking markers;1 - by flanking markers 16;13 1550187;66075608 60316851;98985851 1 - by flanking markers;1 - by flanking markers 13;16 60933298;832236 92436175;56733837 1 - by flanking markers;1 - by flanking markers RRID:RRRC_00709 9685785 SS.LEW-(D1Mco36-D1Mco54)/Bj This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Mco101)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 122991895 129013896 1 - by flanking markers 1 130267716 136181734 1 - by flanking markers 1 129208943 135158838 1 - by flanking markers 1 121833674 127592440 1 - by flanking markers RRID:RGD_9685785 9685787 SS.LEW-(D1Mco36-D1Rat200)/Bj This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Mco101)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 122991895 126939275 1 - by flanking markers 1 130267716 134204042 1 - by flanking markers 1 129208943 133164521 1 - by flanking markers 1 121833674 125611741 1 - by flanking markers RRID:RGD_9685787 9685791 SS.LEW-(D1Mco36-D1Mco61)/Bj This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Mco101)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 122991895 124296272 1 - by flanking markers 1 130267716 131494744 1 - by flanking markers 1 129208943 130446906 1 - by flanking markers 1 121833674 123041501 1 - by flanking markers RRID:RGD_9685791 9685793 SS.LEW-(D1Rat200-D1Mco136)/Bj This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Mco101)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 0 126939275 1 - by flanking markers 1 134116233 134204042 1 - by flanking markers 1 133076978 133164521 1 - by flanking markers 1 125611501 125611741 1 - by flanking markers RRID:RGD_9685793 9685795 SS.LEW-(D1Mco55-D1Wox6)/Bj This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Mco101)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 127933558 131956825 1 - by flanking markers 1 135124726 138778112 1 - by flanking markers 1 134089429 137787460 1 - by flanking markers 1 126540680 126540917 1 - by flanking markers RRID:RGD_9685795 9685797 SS.LEW-(D1Mco134-D1Wox6)/Bj This is a congenic substrain developed by crossing the progenitor strain SS.LEW-(D1Mco36-D1Mco101)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region Medical College of Ohio, Toledo, Ohio, USA congenic Unknown 1 0 131956825 1 - by flanking markers 1 138777913 138778112 1 - by flanking markers 1 137787261 137787460 1 - by flanking markers RRID:RGD_9685797 9831158 Y59/Zgd Strain developed by Prof. Borislav Nakic, Prof. Silobrcic and Prof. Andrija Kastelan from outbred Wistar rats during 1960s, maintained at Department of Animal Physiology,Faculty of Science, University of Zagreb, Republic of Croatia University of Zagreb, Republic of Croatia inbred Live Animals (as of 2020-10-05) Immunology and transplantational research RRID:RGD_9831158 9835401 ZDF-Leprm1Rll The Zucker rats from Charles River (ZDF-Leprfa/Crl) carry the Leprm1Rll allele that has substitution of a nucleotide at 880 (A-C) results in Gln-Pro at position 269 Laboratory of Human Behavior and Metabolism, Rockefeller University, New York mutant Unknown Leprm1Rll 9835400 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RGD_9835401 9835403 WDF-Leprm1Rll The WDF colony at Vassar College (WDF/Vc) carry the Leprm1Rll allele that has substitution of a nucleotide at 880 (A-C) results in Gln-Pro at position 269 Laboratory of Human Behavior and Metabolism, Rockefeller University, New York mutant Unknown Leprm1Rll 9835400 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RGD_9835403 9854707 SHR.WKY-(D4Rat143-D4Rat10)/Tja This congenic strain was generated by introgressing the desired fragment from WKY/NCruk onto the genetic background of SHR/NCruk MRC Clinical Centre, London, UK, Rat Resource and Research Center congenic Unknown Insulin Resistance 4 26280781 26280949 1 - by flanking markers 4 2432766 26659527 1 - by flanking markers 4 2380037 26753822 1 - by flanking markers 4 5867662 29593455 1 - by flanking markers RRID:RRRC_00737 9854709 SHR.WKY-(D12Rat1-D12Mit3)/Tja This congenic strain was generated by introgressing the desired fragment from WKY/NCruk onto the genetic background of SHR/NCruk MRC Clinical Centre, London, UK, Rat Resource and Research Center congenic Unknown Insulin Resistance, Hypertension 12;1 555108;223364189 555654;223364281 1 - by flanking markers;1 - by flanking markers 1;12 245071632;6945260 245071725;7384617 1 - by flanking markers;1 - by flanking markers RRID:RRRC_00738 9854711 SHR.WKY-(D16Rat88-D16Rat15)/Tja This congenic strain was generated by introgressing the desired fragment from WKY/NCruk onto the genetic background of SHR/NCruk MRC Clinical Centre, London, UK, Rat Resource and Research Center congenic Unknown Insulin Resistance 16 819225 80047126 1 - by flanking markers 16 1534408 79886465 1 - by flanking markers 16 1550187 80316424 1 - by flanking markers 16 832236 75226532 1 - by flanking markers RRID:RRRC_00739 9999141 IRL/NCr The IRL/NCr rat strain was received into the NIH Genetic Resources program in 1987, now maintained at NCI Animal production program National Cancer Institute, Animal Production Program, Rat Resource and Research Center inbred Unknown Pulmonary hypertension RRID:RRRC_00732 9999143 LOU/MNCr The NCI Animal Production Program received this rat strain from NIH in 1987 for production and distribution of the LOU/MNCr rat strain National Cancer Institute, Animal Production Program, Rat Resource and Research Center inbred Unknown RRID:RRRC_00733 9999145 F344/NCr The F344/NCr rat strain was received into the NIH Genetic Resources program in 1987, now maintained at NCI Animal production program National Cancer Institute, Animal Production Program, Rat Resource and Research Center inbred Unknown Phenylketonuria RRID:RRRC_00734 10002743 DA.E3-(D20Rat42-D20Rat49)/Rhd A fragment containing MHC region from E3/ZtmRhd was introduced in DA/ZtmRhd by marker-assisted breeding and verified as pure congenic line after six generations of backcross to DA/ZtmRhd. Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown 20 4582054 8286657 1 - by flanking markers 20 6265460 10844146 1 - by flanking markers 20 4186104 8654464 1 - by flanking markers 20 4459698 8042534 1 - by flanking markers RRID:RGD_10002743 10002745 DA.E3-(D20Rat47-AA858870)/Rhd A fragment containing MHC region from E3/ZtmRhd was introduced in DA/ZtmRhd by marker-assisted breeding and verified as pure congenic line after six generations of backcross to DA/ZtmRhd. Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown 20 1616332 5924094 1 - by flanking markers 20 4059279 9491404 1 - by flanking markers 20 2018654 7289058 1 - by flanking markers 20 1527842 5767669 1 - by flanking markers RRID:RGD_10002745 10002782 SHR-Sbf1m1Ipcv Spontaneous mutation in the colony of SHR/OlaIpcv in Prague. Institute of Biology and Medical Genetics, Charles University, Prague mutant Unknown Sbf1m1Ipcv 10002755 7 127583779 127611043 1 - by flanking markers 7 129946572 129973566 1 - by flanking markers 7 130261552 130288566 1 - by flanking markers 7 120358338 120385022 1 - by flanking markers RRID:RGD_10002782 10002787 SD-Krt71m1Yuyi Several rats curled arose spontaneously in a closed colony of SD rats maintained at Laboratory Animal Center of Zhengzhou University. a 3 bp deletion at position 420-422 of Krt71 which results in the deletion of aspartate was identified. Laboratory Animal Center of Zhengzhou University, Henan Province, China mutant Unknown Krt71m1Yuyi 10002785 7 141143396 141166531 1 - by flanking markers 7 143345201 143371346 1 - by flanking markers 7 132873532 132898975 1 - by flanking markers RRID:RGD_10002787 10002791 SD-Fahem3Mcwi This strain was produced by injecting TALENs targeting the sequence CTCAGTGTTCCTACTCTgcccctcccagaggttcaATGCTTTGTGTTCAATGTCG into Crl:SD rat embryos. The resulting mutation is a 1-bp frameshift deletion in exon 3. PhysGen Knockouts mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2021-11-03) Fahem3Mcwi 10002790 1 140851975 140876187 1 - by flanking markers 1 147640316 147662920 1 - by flanking markers 1 146713663 146736339 1 - by flanking markers 1 138548830 138571599 1 - by flanking markers RRID:RGD_10002791 10002794 SD-Il2rgem2Mcwi This strain was produced by injecting TALENs targeting the sequence CTTAGACAACTCTCAATAGCTttatgggcctcggccAAGCGGCATGGAAGGAGGC into Crl:SD rat embryos. The resulting mutation is a 1-bp frameshift deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Il2rgem2Mcwi 10002792 RRID:RGD_10002794 10043120 BBDP.ACI-(D2Mit8-D2Rat69)/Sunn 104 Mb region from ACI.BBDP-(RT1u),(Gimap5)/Sunn is introgressed into the BBDP/WorSunn background which includes Iddm26, Iddm33 QTL regions and a small fragment of Iddm32 Sunnybrook Research Institute, Toronto, Ontario, Canada congenic Unknown 2 148790600 247295816 1 - by flanking markers 2 169047256 272813962 1 - by flanking markers 2 149614466 254121739 1 - by flanking markers 2 143657411 143657569 1 - by flanking markers RRID:RGD_10043120 10043122 BBDP.ACI-(D2Mit8-D2Arb16)(D2Rat354-D2Rat69)/Sunn 104 Mb region from ACI.BBDP-(RT1u)(Gimap5)/Sunn is introgressed into the BBDP/WorSunn background which includes Iddm26, Iddm33 QTL regions and a small fragment of Iddm32 the region from D2Rat99 and D2Rat354 is from the background ACI strain Sunnybrook Research Institute, Toronto, Ontario, Canada congenic Unknown 2;2 199719703;148790600 247295816;198312656 1 - by flanking markers;1 - by flanking markers 2;2 226390296;169047256 272813962;225003755 1 - by flanking markers;1 - by flanking markers 2;2 206966406;149614466 254121739;205573168 1 - by flanking markers;1 - by flanking markers 2;2 143657411;191987426 190602963;191987650 1 - by flanking markers;1 - by flanking markers RRID:RGD_10043122 10043124 BBDP.ACI-(D2Mit8-D2Arb16)/Sunn 104 Mb region from ACI.BBDP-(RT1u),(Gimap5)/Sunn is introgressed into the BBDP/WorSunn background which carries the centromeric region of Iddm26 and a small fragment of Iddm32 Sunnybrook Research Institute, Toronto, Ontario, Canada congenic Unknown 2 148790600 198312656 1 - by flanking markers 2 169047256 225003755 1 - by flanking markers 2 149614466 205573168 1 - by flanking markers 2 143657411 190602963 1 - by flanking markers RRID:RGD_10043124 10043127 BBDP.ACI-(D2Mit8-D2Rat354)/Sunn 104 Mb region from ACI.BBDP-(RT1u),(Gimap5)/Sunn is introgressed into the BBDP/WorSunn background which carries the centromeric region of Iddm26 and a small fragment of Iddm32 Sunnybrook Research Institute, Toronto, Ontario, Canada congenic Unknown 2 148790600 199719925 1 - by flanking markers 2 169047256 226390517 1 - by flanking markers 2 149614466 206966627 1 - by flanking markers 2 143657411 191987650 1 - by flanking markers RRID:RGD_10043127 10043129 BBDP.ACI-(D2Arb16-D2Rat63)/Sunn 104 Mb region from ACI.BBDP-(RT1u),(Gimap5)/Sunn is introgressed into the BBDP/WorSunn background which carries the centromeric region of Iddm33 and telomeric region of Iddm26 Sunnybrook Research Institute, Toronto, Ontario, Canada congenic Unknown 2 198312439 231465091 1 - by flanking markers 2 225003539 257699856 1 - by flanking markers 2 205572952 239166203 1 - by flanking markers 2 190602746 222436696 1 - by flanking markers RRID:RGD_10043129 10043132 BBDP.ACI-(D2Rat50-D2Rat63)/Sunn 104 Mb region from ACI.BBDP-(RT1u),(Gimap5)/Sunn is introgressed into the BBDP/WorSunn background which carries the centromeric region of Iddm33 and telomeric region of Iddm26 Sunnybrook Research Institute, Toronto, Ontario, Canada congenic Unknown 2 200390326 231465091 1 - by flanking markers 2 227035223 257699856 1 - by flanking markers 2 207612323 239166203 1 - by flanking markers 2 192625307 222436696 1 - by flanking markers RRID:RGD_10043132 10043368 NER.F344-(D3M2Mit327-D3Arb10)/Kyo The chromosome 3 region (D3M2Mit327-D3Arb10) was introgressed from F344/NSlc to NER/Kyo by backcrossing.（Sep 12, 2012） National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology 3 0 93413837 1 - by flanking markers RRID:RGD_10043368 10043382 F344.NER-(D1Mgh6-D1Rat73)(D5Mgh4-D5Rat36)Lgi1m1/Kyo Triple congenic rat made by mating F344.NER-(D1Mgh6-D1Rat132)(D5Mgh4-D5Rat36)/Kyo and F344-Lgi1m1Kyo. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology Lgi1 628742 5;1 145186817;87656636 145187034;224420760 1 - by flanking markers;1 - by flanking markers 5;1 147610023;92524380 147610238;246113473 1 - by flanking markers;1 - by flanking markers 5;1 143846157;91394009 143846372;238824901 1 - by flanking markers;1 - by flanking markers 1;5 87790149;138113556 218748178;138113774 1 - by flanking markers;1 - by flanking markers RRID:RGD_10043382 10043385 F344.NER-(D1Mgh6-D1Rat73)(D5Mgh4-D5Rat36)Scn1am1/Kyo Triple congenic rat made by mating F344.NER-(D1Mgh6-D1Rat132)(D5Mgh4-D5Rat36)/Kyo and F344-LScn1am1Kyo. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Neurobiology Scn1a 69364 5;3;1 145186817;48238528;87656636 145187034;48364143;224420760 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 5;3;1 147610023;59016641;92524380 147610238;59135580;246113473 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 5;3;1 143846157;52388811;91394009 143846372;52533365;238824901 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 5;1;3 138113556;87790149;50952790 138113774;218748178;51071804 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers RRID:RGD_10043385 10043617 SPRD-Anks6PKD/Fsn This strain rats was provided to University of Kansas from Central Institute for Laboratory Animal Breeding (Hanover, Germany), and then was introduced to Fujita Health University. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2018-04-20) Anks6PKD 11534996 5 63633540 63674953 1 - by flanking markers 5 67163440 67204853 1 - by flanking markers 5 62642974 62684387 1 - by flanking markers 5 61309183 61350596 1 - by flanking markers RRID:RGD_10043617 10043620 SHRSP.WKY-(D1Smu13)/Izm This congenic strain was made by introducing chromosome 1 region (D1Smu13) of WKY into SHRSP/Izm. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio Hypertension 1 173074640 173074855 1 - by flanking markers 1 166884926 166885141 1 - by flanking markers 1 156170341 156170557 1 - by flanking markers RRID:RGD_10043620 10043791 SHRSP.SHR-(D1Mgh5-D1Rat213)/Izm male SHRSP.SHR-(D1Rat93-D1Rat269)/Izm were crossed with female SHRSP/Izm and the offsprings were intercrossed, animals were genotyped to get the desired recombinants which were then backcrossed to SHRSP/Izm Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan, National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio-Hypertension 1 78134304 81548909 1 - by flanking markers 1 80946174 84537228 1 - by flanking markers 1 79689548 83282814 1 - by flanking markers 1 78430536 81777720 1 - by flanking markers RRID:RGD_10043791 10043794 WKY.SHRSP-(D1Mgh5-D1Arb21)/Izm A congenic strain made by introducing a segments of chromosome 1 from SHRSP/Izm into WKY/Izm. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio-Hypertension 1 78134304 187092492 1 - by flanking markers 1 80946174 206277202 1 - by flanking markers 1 79689548 199254774 1 - by flanking markers 1 78430536 182418476 1 - by flanking markers RRID:RGD_10043794 10043808 WKY.SHRSP-(D1Mgh5-D1Arb21)(D4Mgh7-D4Rat68)/Izm A congenic strain made by introducing a segments of chromosome 1 from SHRSP/Izm into WKY/Izm. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm Cardio-Hypertension 4;1 172169471;78134304 172169650;187092492 1 - by flanking markers;1 - by flanking markers 4;1 200825021;80946174 233267140;206277202 1 - by flanking markers;1 - by flanking markers 4;1 136351734;79689548 168998263;199254774 1 - by flanking markers;1 - by flanking markers 1;4 78430536;138503169 182418476;168069246 1 - by flanking markers;1 - by flanking markers RRID:RGD_10043808 10043811 SHRSP.MES-CybaMES/Izm A congenic strain made by introducing a genetic locus of Cyba from Matsumoto Eosinophilic Shinshu (MES/Slc) rat into SHRSP/Izm rat. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Cardio-Hypertension RRID:RGD_10043811 10043813 SHR/HktIzm SHR/Kyushu rat (Kyushu University) was delivered to Shimane University in 2000 and maintained as inbred. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio-Hypertension RRID:RGD_10043813 10043816 LEA-Tg(Pou5f1-YFP*)3Ncco Provided from Kyoto Bioresource center. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Oncology, Development RRID:RGD_10043816 10043826 SHR/Kpo Spontaneously hypertensive rat (SHR) was segregated in Wistar-Kyoto rat in 1963. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Cardio-Hypertension RRID:RGD_10043826 10043828 SHR/2Kpo Spontaneously hypertensive rat (SHR) was segregated in Wistar-Kyoto rat in 1963. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Cardio-Hypertension RRID:RGD_10043828 10044232 SHRSP/Kpo Okamoto et al. found some rats that have cerebrovascular lesion in SHR rats (especially in line A). This strain was established in 1974 and named stroke-prone SHR (SHRSP) rat. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio-Hypertension RRID:RGD_10044232 10045545 CDS/Sasz Cohen diabetic-sensitive rat Original breeders are from a colony at Hadassah University Hospital, Jerusalem, Israel: Professor Cohen AM et al. initiated the Cohen diabetic (CD) rat model at the Hadassah University Hospital in the 1950s to examine the role of constitutional (genetic) and environmental (dietary) factors in the development of type 2 diabetes mellitus. Since 1996, the original colony underwent a secondary inbreeding by Dr. Sarah Zangen designated by Prof. Cohen as responsible for the Cohen diabetic (CD) rat colony. Hebrew University-Hadassah Medical School, Jerusalem, Israel inbred Unknown RRID:RGD_10045545 10045548 CDR/Sasz Cohen diabetic-rssistant rat Original breeders are from a colony at Hadassah University Hospital, Jerusalem, Israel: Professor Cohen AM et al. initiated the Cohen diabetic (CD) rat model at the Hadassah University Hospital in the 1950s to examine the role of constitutional (genetic) and environmental (dietary) factors in the development of type 2 diabetes mellitus. Since 1996, the original colony underwent a secondary inbreeding by Dr. Sarah Zangen designated by Prof. Cohen as responsible for the Cohen diabetic (CD) rat colony. Hebrew University-Hadassah Medical School, Jerusalem, Israel inbred Unknown RRID:RGD_10045548 10045576 SHRSP/2Kpo Okamoto et al. found some rats that have cerebrovascular lesion in SHR rats (especially in line A). This strain was established in 1974 and named stroke-prone SHR (SHRSP) rat. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo; Cryopreserved Sperm Cardio-Hypertension RRID:RGD_10045576 10045578 MSHRSP/Kpo Okamoto et al. found that a few rats developed higher blood pressure (over 230 mmHg) at 10 weeks old. They selected SHRSP rats that show severe hypertension from young age and M-SHRSP (malignant or precocious SHRSP) rat was established in 1985. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo Cardio-Hypertension RRID:RGD_10045578 10045580 LE-Tg((ROSA26)Sor-CAG-tdTomato)24Jfhy Background strain: Long Evans | Transgene: CAG-loxP-flanked Neo/STOP cassette-tdTomato was inserted into mouse ROSA26 BAC (RP23 244D9). National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2016-11-15) RRID:RGD_10045580 10045582 ODURM/Odu This strain shows malocclusion. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm Dentistry RRID:RGD_10045582 10045584 SD-Tg(CAG-HRAS*G12V)218Htsu The transgene consisting of CAG promoter/loxP/neomycin resistant gene casette/lox/Ha-ras*G12V（HrasV12）was injected into embryos of SD rat (Jcl:SD). This strain was generated at CLEA Japan,Inc. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Oncology RRID:RGD_10045584 10045589 SD-Tg(CAG-HRAS*G12V)246Htsu The transgene consisting of CAG promoter/loxP/neomycin resistant gene casette/lox/Ha-ras*G12V（HrasV12）was injected into embryos of SD rat (Jcl:SD). This strain was generated at CLEA Japan,Inc. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Oncology RRID:RGD_10045589 10045590 LEA.F344-(D20Rat47-D20Mgh4)/Tj Long-Evans Agouti (LEA), type 2 diabetes model, dies from lymphocytic insulitis induced by radiation (4 Gy). This LEA.F344-(D20Rat47-D20Mgh4) strain is a congenic strain made by introducing a segment of chromosome 20 (D20Rat47-D20Mgh4) from F344 strain into LEA strain. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity 20 1616332 6880472 1 - by flanking markers 20 4059279 7910747 1 - by flanking markers 20 2018654 5875448 1 - by flanking markers 20 1527842 6691706 1 - by flanking markers RRID:RGD_10045590 10045591 F344-Cacna1agryScn1am1Kyo/Okym GRY/Idr (GRY/Idr has the M251K mutation in the Cacna1a gene) was backcrossed to F344/NSlc, and then crossed to HISS rat (HISS rat has the N1417H mutation in the Scn1a gene) to generate Scn1a/Cacna1a double mutant rats. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2017-05-05) Neurobiology Cacna1a|Scn1am1Kyo|Cacna1agry 2244|12792283|12880382 19 25188170 25424495 1 - by flanking markers 19 36502533 36727039 1 - by flanking markers 19 25453236 25749550 1 - by flanking markers 19 23520741 23819971 1 - by flanking markers RRID:RGD_10045591 10045593 W-Dmdem1Kykn By CRISPR/Cas9 system, mutation was introduced in dystrophin (Dmd) gene of Wistar-Imamichi rat. The resulting mutation is a 329-bp deletion around exon 3 and 2-bp substitution in exon16. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2016-12-08) Neurobiology Dmdem1Kykn 10045592 X 71501362 71671414 1 - by flanking markers X 51475950 53700033 1 - by flanking markers X 51149358 53519271 1 - by flanking markers X 47272324 49504219 1 - by flanking markers RRID:RGD_10045593 10045597 F344-Nfe2l2em1Kyo Zinc-finger nucleases (ZFNs) method targeting exon 5 of Nfe2l2 (Nrf2) (ACCACTGTCCCCAGCCCAgaggccACACTGACAGAGATGGAC) was used; This strain has a 7-bp deletion in Nfe2l2 (Nrf2) gene. National BioResource Project for the Rat in Japan mutant Unknown Neurobiology; Diabetes Obesity Nfe2l2em1Kyo 10045594 3 58366693 58394116 1 - by flanking markers 3 69041641 69069190 1 - by flanking markers 3 62497568 62525146 1 - by flanking markers 3 60594239 60621785 1 - by flanking markers RRID:RGD_10045597 10045600 F344-Nfe2l2em2Kyo Zinc-finger nucleases (ZFNs) method targeting exon 5 of Nfe2l2 (Nrf2) (ACCACTGTCCCCAGCCCAgaggccACACTGACAGAGATGGAC) was used; This strain has a 1 bp insertion in Nfe2l2 gene. National BioResource Project for the Rat in Japan mutant Unknown Neurobiology; Diabetes Obesity Nfe2l2em2Kyo 10045598 3 58366693 58394116 1 - by flanking markers 3 69041641 69069190 1 - by flanking markers 3 62497568 62525146 1 - by flanking markers 3 60594239 60621785 1 - by flanking markers RRID:RGD_10045600 10045602 W-Tg(CMV-Ddx54)19Tsuy This transgenic rat was established by microinjection of transgene consisting of Ddx54 gene (NM_001191548.1) driven by CMV promoter (pCMV-Tag2B) derived from cytomegalovirus into Wistar rat (SLC) pronuclear fertile eggs at UNITECH Co., Ltd. in 2007. National BioResource Project for the Rat in Japan transgenic Unknown Neurobiology RRID:RGD_10045602 10045606 W-Tg(CMV-Ddx54)37Tsuy This transgenic rat was established by microinjection of transgene consisting of Ddx54 gene (NM_001191548.1) driven by CMV promoter (pCMV-Tag2B) derived from cytomegalovirus into Wistar rat (SLC) pronuclear fertile eggs at UNITECH Co., Ltd. in 2007. National BioResource Project for the Rat in Japan transgenic Unknown Neurobiology RRID:RGD_10045606 10046035 SS.SR-(D13Arb5-D13Arb8)/Mcwi A region of chromosome 13 containing the renin gene from the Dahl salt-resistant (Dahl R; SR/JrHsd) strain into the SS genetic background (SS/JrHsdMcwi) Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 38985717 47698301 1 - by flanking markers 13 47898759 56629737 1 - by flanking markers 13 42794724 51577031 1 - by flanking markers 13 37902608 46193066 1 - by flanking markers RRID:RGD_10046035 10047085 SD-Fusem1Ionsz CRISPR/Cas9 system was used to generate this mutant; sgRNA+Cas9+Oligo was injected into zygote of SD rat. The mutation changed the 521th amino acid Arg (R) into Cys (C). Institute of Neuroscience, Chinese Academy of Sciences mutant Unknown Fusem1Ionsz 10047084 1 187250871 187264742 1 - by flanking markers 1 206435510 206449423 1 - by flanking markers 1 199412805 199426705 1 - by flanking markers 1 182576479 182590417 1 - by flanking markers RRID:RGD_10047085 10047391 LE/OrlBarth Long-Evans/Cryptorchid Obtained from Centre Nationale de la Researche Scientifique, Orleans, France; then bred at A.I. duPont Hospital for Children Life Science Center, Wilmington, Delaware A.I. duPont Hospital for Children Life Science Center, Wilmington, Delaware inbred Unknown RRID:RGD_10047391 10047393 SDLEF7/Barth This hybrid strain was created by interbreeding Crl:SD and Crl:LE for F7 generation. A.I. duPont Hospital for Children Life Science Center, Wilmington, Delaware hybrid Unknown RRID:RGD_10047393 10053598 WI-Foxn1em1Nips Foxn1 mutation was induced by injecting pX330 espressing Cas9 and sgRNA targeting the sequence GACTGGAGGGCGAACCCCAA into Crlj:WI rat embryos. The resulting mutation is a 44-bp frameshift deletion in exon 1 (del 54-97). Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN mutant Unknown Foxn1em1Nips 10053596 10 64243323 64256847 1 - by flanking markers 10 66004940 66030134 1 - by flanking markers 10 65621142 65634666 1 - by flanking markers 10 63251400 63273710 1 - by flanking markers RRID:RGD_10053598 10053601 WI-Foxn1em2Nips Foxn1 mutation was induced by injecting pX330 espressing Cas9 and sgRNA targeting the sequence GACTGGAGGGCGAACCCCAA into Crlj:WI rat embryos. The resulting mutation is a 60-bp frameshift deletion in exon 1 (del 46-105). Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN mutant Unknown Foxn1em2Nips 10053599 10 64243323 64256847 1 - by flanking markers 10 66004940 66030134 1 - by flanking markers 10 65621142 65634666 1 - by flanking markers 10 63251400 63273710 1 - by flanking markers RRID:RGD_10053601 10054231 HFJ/Hblac bred from Wistar rats that were from National Resource Center (NRLARC) for Rodent Laboratory Animal (Beijing, China) Hebei Medical University, Shijiazhuang, Hebei, China inbred Unknown RRID:RGD_10054231 10054233 MIJ/Hblac bred from Wistar rats that were from National Resource Center (NRLARC) for Rodent Laboratory Animal (Beijing, China) Hebei Medical University, Shijiazhuang, Hebei, China inbred Unknown RRID:RGD_10054233 10054235 MIJN/Hblac this strain is derived from MIJ/Hblac, they do not carry the infertile gene Hebei Medical University, Shijiazhuang, Hebei, China coisogenic Unknown RRID:RGD_10054235 10054239 DA-Abcd1em2Mcwi CRISPR/Cas9 system was used to introduce a 2-bp insertion mutation in the exon1 of the Abcd1 gene of DA/OlaHsd rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-22) Abcd1em2Mcwi 10054237 X 159614569 159635963 1 - by flanking markers 1 152823436 152844829 1 - by flanking markers X 157073860 157095652 1 - by flanking markers X 151428334 151450115 1 - by flanking markers RRID:RGD_10054239 10054242 DA-Abcd1em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Abcd1 gene of DA/OlaHsd rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Extinct (as of 2016-10-24) Abcd1em4Mcwi 10054240 X 159614569 159635963 1 - by flanking markers 1 152823436 152844829 1 - by flanking markers X 157073860 157095652 1 - by flanking markers X 151428334 151450115 1 - by flanking markers RRID:RGD_10054242 10054245 SS-Adora1em3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Adora1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion in the Adora1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-22) Adora1em3Mcwi 10054243 13 47160292 47192804 1 - by flanking markers 13 56097883 56132155 1 - by flanking markers 13 51042111 51076913 1 - by flanking markers 13 45658872 45695821 1 - by flanking markers RRID:RGD_10054245 10054276 SD-Vcpem1Ionsz CRISPR/Cas9 system was used to generate this mutant; sgRNA+Cas9+Oligo was injected into zygote of SD rat that made the 155th amino acid Arg into His Institute of Neuroscience, Chinese Academy of Sciences mutant Unknown Vcpem1Ionsz 10054274 RRID:RGD_10054276 10054279 SD-Gfapem1(2A-Chr2-EYFP)Ionsz CRISPR/Cas9 system was used to generate this mutant; sgRNA+Cas9+ plasmid was injected into zygote of SD rat that added a 2A ( the self-cleaving 2A peptide sequence from foot-and-mouth disease virus or other picornaviruses), blue light-gated cation channel channelrhodopsin-2 (ChR2) and EYFP behind the last exon of Gfap. Institute of Neuroscience, Chinese Academy of Sciences mutant Unknown Gfapem1Ionsz 10054277 RRID:RGD_10054279 10054284 SS-Adora1em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Adora1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 34-bp deletion in the Adora1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-22) Adora1em4Mcwi 10054282 13 47160292 47192804 1 - by flanking markers 13 56097883 56132155 1 - by flanking markers 13 51042111 51076913 1 - by flanking markers 13 45658872 45695821 1 - by flanking markers RRID:RGD_10054284 10054287 SS-Adora2aem3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Adora2a gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 98-bp deletion in the Adora2a gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals; Cryopreserved Sperm (as of 2017-01-26) Adora2aem3Mcwi 10054285 20 13815719 13834131 1 - by flanking markers 20 16449385 16466147 1 - by flanking markers 20 14265251 14282873 1 - by flanking markers 20 13315848 13333386 1 - by flanking markers RRID:RGD_10054287 10054292 SS-Arhgef11em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Arhgef11 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 17-bp deletion in the Arhgef11 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Arhgef11em4Mcwi 10054289 2 179676236 179796785 1 - by flanking markers 2 206384799 206507431 1 - by flanking markers 2 186979850 187102523 1 - by flanking markers 2 173074383 173195962 1 - by flanking markers RRID:RGD_10054292 10054296 SS-Arhgef11em5Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Arhgef11 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp deletion in the Arhgef11 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-22) Arhgef11em5Mcwi 10054293 2 179676236 179796785 1 - by flanking markers 2 206384799 206507431 1 - by flanking markers 2 186979850 187102523 1 - by flanking markers 2 173074383 173195962 1 - by flanking markers RRID:RGD_10054296 10054299 SS.BN-(D13Rat25-rs106935835)-Btg2em11Mcwi CRISPR/Cas9 system was used to introduce a 16-bp deletion in the Btg2 gene of SS.BN-(D13Rat25-rs106935835)/Mcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Btg2em11Mcwi 10054297 13 47026986 47030745 1 - by flanking markers 13 55966299 55970058 1 - by flanking markers 13 50913185 50916944 1 - by flanking markers 13 45531881 45535642 1 - by flanking markers RRID:RGD_10054299 10054304 SS.BN-(D13Rat25-rs106935835)-Btg2em13Mcwi CRISPR/Cas9 system was used to introduce a 2-bp deletion in the Btg2 gene of SS.BN-(D13Rat25-rs106935835)/Mcwi rat embryos MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Btg2em13Mcwi 10054302 13 47026986 47030745 1 - by flanking markers 13 55966299 55970058 1 - by flanking markers 13 50913185 50916944 1 - by flanking markers 13 45531881 45535642 1 - by flanking markers RRID:RGD_10054304 10054307 SS.BN-(D13Rat25-rs106935835)-Btg2em7Mcwi The Btg2 mutant rats were generated using transcription activator-like effector nuclease (TALEN) constructs specific for the rat Btg2 gene designed to target exon 1 using the target sequence TAGGTTTCCTCACCAGTCtcctgaggactcggggcTGCGTGAGCGAGCAGAGA. The result was a 44-bp deletion mutation in exon 1 (RNO13:50,916,769-50,916,812; aaaccttgagtctctgctcgctcacgcagccccgagtcctcagg) of SS.BN-(D13Rat25-rs106935835)/Mcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals; Cryopreserved Sperm (as of 2021-11-03) Btg2em7Mcwi 10054305 13 47026986 47030745 1 - by flanking markers 13 55966299 55970058 1 - by flanking markers 13 50913185 50916944 1 - by flanking markers 13 45531881 45535642 1 - by flanking markers RRID:RGD_10054307 10054310 SS-Casrem1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Casr gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp (T) insertion in the Casr gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-22) Casrem1Mcwi 10054308 11 66084169 66153292 1 - by flanking markers 11 70278784 70352137 1 - by flanking markers 11 67188204 67262261 1 - by flanking markers 11 64235251 64304811 1 - by flanking markers RRID:RGD_10054310 10054376 LEW-Chrna3em9Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Chrna3 gene of LEW/NCrl rat embryos. The resulting mutation is a 17-bp deletion in the Chrna3 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-11-26) Chrna3em9Mcwi 10054374 8 58570223 58583594 1 - by flanking markers 8 58176165 58189008 1 - by flanking markers 8 59594007 59607122 1 - by flanking markers 8 55401981 55415012 1 - by flanking markers RRID:RGD_10054376 10054379 LEW-Chrna4em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Chrna4 gene of LEW/NCrl rat embryos. The resulting mutation is a 5-bp deletion in the Chrna4 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-11-26) Chrna4em4Mcwi 10054377 3 170171214 170185998 1 - by flanking markers 3 180243234 180258017 1 - by flanking markers 3 176533182 176547965 1 - by flanking markers 3 168136246 168157839 1 - by flanking markers RRID:RGD_10054379 10054383 LEW-Chrna4em3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Chrna4 gene of LEW/NCrl rat embryos. The resulting mutation is a 17-bp deletion in the Chrna4 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-11-26) Chrna4em3Mcwi 10054380 3 170171214 170185998 1 - by flanking markers 3 180243234 180258017 1 - by flanking markers 3 176533182 176547965 1 - by flanking markers 3 168136246 168157839 1 - by flanking markers RRID:RGD_10054383 10054386 LEW-Chrna5em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Chrna5 gene of LEW/NCrl rat embryos. The resulting mutation is a 1-bp insertion in the Chrna5 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-11-26) Chrna5em1Mcwi 10054384 8 58538002 58566388 1 - by flanking markers 8 58143974 58172330 1 - by flanking markers 8 59561817 59590172 1 - by flanking markers 8 55369794 55398526 1 - by flanking markers RRID:RGD_10054386 10054389 LEW-Chrna5em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Chrna5 gene of LEW/NCrl rat embryos. The resulting mutation is a 20-bp deletion in the Chrna5 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-11-26) Chrna5em2Mcwi 10054387 8 58538002 58566388 1 - by flanking markers 8 58143974 58172330 1 - by flanking markers 8 59561817 59590172 1 - by flanking markers 8 55369794 55398526 1 - by flanking markers RRID:RGD_10054389 10054398 DA-Glaem2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Gla gene of DA/OlaHsd rat embryos. The resulting mutation is a 47-bp deletion in the Gla gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals; Cryopreserved Sperm (as of 2018-10-22) Glaem2Mcwi 10054395 X 122044703 122056327 1 - by flanking markers X 105295029 105306686 1 - by flanking markers X 105405915 105417331 1 - by flanking markers X 97769227 97780646 1 - by flanking markers RRID:RGD_10054398 10054401 FHH-Chr 3BN-Helz2em3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Helz2 gene of FHH-Chr 3BN/Mcwi rat embryos.The resulting mutation is a 11-bp deletion in the Helz2 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals; Cryopreserved Sperm (as of 2018-10-22) Helz2em3Mcwi 10054399 3 170368815 170382086 1 - by flanking markers 3 180439958 180454321 1 - by flanking markers 3 176730024 176744382 1 - by flanking markers 3 168338813 168353219 1 - by flanking markers RRID:RGD_10054401 10054405 FHH-Chr 3BN-Helz2em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Helz2 gene of FHH-Chr 3BN/Mcwi rat embryos.The resulting mutation is a 1-bp insertion in the Helz2 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-22) Helz2em4Mcwi 10054402 3 170368815 170382086 1 - by flanking markers 3 180439958 180454321 1 - by flanking markers 3 176730024 176744382 1 - by flanking markers 3 168338813 168353219 1 - by flanking markers RRID:RGD_10054405 10054408 SS-Kcnj10em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Kcnj10 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp insertion in the Kcnj10 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Kcnj10em1Mcwi 10054406 13 88341102 88370591 1 - by flanking markers 13 95245046 95274535 1 - by flanking markers 13 90722945 90753338 1 - by flanking markers 13 84802026 84835383 1 - by flanking markers RRID:RGD_10054408 10054411 SS-Kcnj10em3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Kcnj10 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 3-bp deletion in the Kcnj10 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-22) Kcnj10em3Mcwi 10054409 13 88341102 88370591 1 - by flanking markers 13 95245046 95274535 1 - by flanking markers 13 90722945 90753338 1 - by flanking markers 13 84802026 84835383 1 - by flanking markers RRID:RGD_10054411 10054414 SS-Mmp9em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Mmp9 gene of SS/JrHsdMcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Mmp9em4Mcwi 12743378 3 155985473 155993433 1 - by flanking markers 3 167578904 167605890 1 - by flanking markers 3 161413410 161421473 1 - by flanking markers 3 153684158 153692118 1 - by flanking markers RRID:RGD_10054414 10054417 SS-Mmp9em6Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Mmp9 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp insertion in the Mmp9 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Mmp9em6Mcwi 10054415 3 155985473 155993433 1 - by flanking markers 3 167578904 167605890 1 - by flanking markers 3 161413410 161421473 1 - by flanking markers 3 153684158 153692118 1 - by flanking markers RRID:RGD_10054417 10054420 LEW-Mrpl28em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Mprl28 gene of LEW/NCrl rat embryos. The resulting mutation is a 2-bp insertion in the Mrpl28 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Mrpl28em1Mcwi 10054418 10 15394360 15397270 1 - by flanking markers 10 15309316 15312227 1 - by flanking markers 10 15495616 15498527 1 - by flanking markers 10 15148670 15151581 1 - by flanking markers RRID:RGD_10054420 10054430 LEW-Pkd1em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Pkd1 gene of LEW/NCrl rat embryos. The resulting mutation is a 15-bp deletion in the Pkd1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Pkd1em2Mcwi 10054428 10 13801445 13848212 1 - by flanking markers 10 13731035 13778993 1 - by flanking markers 10 13914057 13962008 1 - by flanking markers 10 13573779 13621138 1 - by flanking markers RRID:RGD_10054430 10054433 LEW-Pkd1em3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Pkd1 gene of LEW/NCrl rat embryos. The resulting mutation is a 12-bp deletion in the Pkd1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-22) Pkd1em3Mcwi 10054431 10 13801445 13848212 1 - by flanking markers 10 13731035 13778993 1 - by flanking markers 10 13914057 13962008 1 - by flanking markers 10 13573779 13621138 1 - by flanking markers RRID:RGD_10054433 10054436 LEW-Pkd1em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Pkd1 gene of LEW/Crl rat embryos. The resulting mutation is a 16-bp deletion in the Pkd1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Extinct (as of 2017-01-26) Pkd1em1Mcwi 10054434 10 13801445 13848212 1 - by flanking markers 10 13731035 13778993 1 - by flanking markers 10 13914057 13962008 1 - by flanking markers 10 13573779 13621138 1 - by flanking markers RRID:RGD_10054436 10054439 LEW-Pkd1em6Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Pkd1 gene of LEW/NCrl rat embryos. The resulting mutation is a 8-bp deletion in the Pkd1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals; Cryopreserved Sperm (as of 2018-10-22) Pkd1em6Mcwi 10054437 10 13801445 13848212 1 - by flanking markers 10 13731035 13778993 1 - by flanking markers 10 13914057 13962008 1 - by flanking markers 10 13573779 13621138 1 - by flanking markers RRID:RGD_10054439 10054444 LEW-Rorcem3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Rorc gene of LEW/NCrl rat embryos. The resulting mutation is a 8-bp deletion in the Rorc gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Rorcem3Mcwi 10054442 2 189345134 189369442 1 - by flanking markers 2 195612471 195636797 1 - by flanking markers 2 182009707 182034910 1 - by flanking markers RRID:RGD_10054444 10054447 LEW-Rorcem5Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Rorc gene of LEW/NCrl rat embryos. The resulting mutation is a 59-bp deletion in the Rorc gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Rorcem5Mcwi 10054445 2 189345134 189369442 1 - by flanking markers 2 195612471 195636797 1 - by flanking markers 2 182009707 182034910 1 - by flanking markers RRID:RGD_10054447 10054450 SS-Sirt3em25Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Sirt3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp deletion in the Sirt3 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-22) Sirt3em25Mcwi 10054448 1 201021391 201043756 1 - by flanking markers 1 220539132 220561380 1 - by flanking markers 1 213613502 213636061 1 - by flanking markers 1 195942066 195964472 1 - by flanking markers RRID:RGD_10054450 10054453 SS-Sirt3em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Sirt3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion in the Sirt3 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Sirt3em4Mcwi 10054451 1 201021391 201043756 1 - by flanking markers 1 220539132 220561380 1 - by flanking markers 1 213613502 213636061 1 - by flanking markers 1 195942066 195964472 1 - by flanking markers RRID:RGD_10054453 10054456 T2DN-Sirt3em35Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Sirt3 gene of T2DN/Mcwi rat embryos. The resulting mutation is a 82-bp deletion of exon 3 in the Sirt3 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-22) Sirt3em35Mcwi 10054454 1 201021391 201043756 1 - by flanking markers 1 220539132 220561380 1 - by flanking markers 1 213613502 213636061 1 - by flanking markers 1 195942066 195964472 1 - by flanking markers RRID:RGD_10054456 10054459 T2DN-Sirt3em30Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Sirt3 gene of T2DN/Mcwi rat embryos. The resulting mutation is a 31-bp deletion in the Sirt3 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Sirt3em30Mcwi 10054457 1 201021391 201043756 1 - by flanking markers 1 220539132 220561380 1 - by flanking markers 1 213613502 213636061 1 - by flanking markers 1 195942066 195964472 1 - by flanking markers RRID:RGD_10054459 10054462 SS-Stk39em5Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Stk39 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 2-bp del in exon 5 in the Stk39 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Stk39em5Mcwi 10054460 3 50249626 50517085 1 - by flanking markers 3 60973443 61244306 1 - by flanking markers 3 54359449 54625702 1 - by flanking markers 3 52913583 53179060 1 - by flanking markers RRID:RGD_10054462 10054465 SS-Stk39em6Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Stk39 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp insertion in the Stk39 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Stk39em6Mcwi 10054463 3 50249626 50517085 1 - by flanking markers 3 60973443 61244306 1 - by flanking markers 3 54359449 54625702 1 - by flanking markers 3 52913583 53179060 1 - by flanking markers RRID:RGD_10054465 10054473 SS.BN-(D13Rat124-D13Hmgc3694)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 0 46721269 1 - by flanking markers 13 55662705 55662936 1 - by flanking markers 13 50609228 50609459 1 - by flanking markers 13 45228358 45228590 1 - by flanking markers RRID:RGD_10054473 10059570 WI-Kiss1tm1Nips This strain was made by electroporation of WDB/Nips-ES1/Nips (RGD ID:10054010) embryonic stem cells with a targeting vector. Homologous recombination of the rKiss1 targeting construct (13.4kb) result in the deletion of 2.5 kb of the Kiss1 locus, consisting of 88 bp of the first coding exon, all of the 2.0-kb downstream intron, and 319 bp of the second coding exon, covering all of the coding region of this exon including the key active region of the processed peptide. Founder animals were backcrossed to Crlj:WI. National Institute for Physiological Sciences, Okazaki Aichi, JAPAN, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan mutant Unknown Kiss1tm1Nips 40902862 13 46244786 46247288 1 - by flanking markers 13 55582365 55590432 1 - by flanking markers 13 50529506 50537603 1 - by flanking markers 13 44774823 44780707 1 - by flanking markers RRID:RGD_10059570 10059573 SS-Adora2aem5Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Adora2a gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion and 5-bp insertion in the Adora2a gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Adora2aem5Mcwi 10059571 20 13815719 13834131 1 - by flanking markers 20 16449385 16466147 1 - by flanking markers 20 14265251 14282873 1 - by flanking markers 20 13315848 13333386 1 - by flanking markers RRID:RGD_10059573 10059576 WKY-Sik2em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Sik2 gene of WKY/NCrl rat embryos. The resulting mutation is a 4-bp deletion in exon 4 of the Sik2 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Sik2em4Mcwi 10059574 8 54240307 54337976 1 - by flanking markers 8 53905730 54005295 1 - by flanking markers 8 55309005 55408608 1 - by flanking markers 8 51225543 51325343 1 - by flanking markers RRID:RGD_10059576 10059635 W-Tg(GnRH-GFP)Mni generated by Dr. Masugi Nishihara's group Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Tokyo Japan transgenic Unknown RRID:RGD_10059635 10395226 Sim:LE Long Evans Received from Dr. Evans, University of California, Berkeley - Experimental Institute of Biology in 1949. Caesarean rederived in 1997. Selection is based on the black-hooded phenotype. Simonsen Laboratories outbred Unknown RRID:RGD_10395226 10395228 Sim:WI Wistar Received from the Lobund Institute, University of Notre Dame in 1957. Caesarean rederived in 1997. Simonsen Laboratories outbred Unknown RRID:RGD_10395228 10395233 Sim:SD Sprague-Dawley Derived Received Sprague-Dawley derived breeding stock from Charles River Laboratory in 1958 and crossed with Sprague-Dawley rats received from ARS/Sprague-Dawley in 1975. Caesarean rederived in 1997. Simonsen Laboratories outbred Unknown RRID:RGD_10395233 10395235 F344/NSim FISCHER 344 Gnotobiotic pedigreed breeders received from the NIH repository colony in 2005. Most widely used inbred rat strain, particularly for toxicology and teratology. Simonsen Laboratories inbred Unknown RRID:RGD_10395235 10395249 FHH.FHH.3BN-(3p-D3Rat98)/Mcwi (FHH X FHH-3BN/Mcwi) F2 males were backcrossed with FHH-3BN/Mcwi females to produce offsprings, these were intercrossed to generate this congenic line Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 3 30253942 30254280 1 - by flanking markers 3 38636977 38637167 1 - by flanking markers 3 33477354 33477544 1 - by flanking markers 3 33703347 33703538 1 - by flanking markers RRID:RGD_10395249 10395251 FHH.FHH.3BN-(D3Hmgc24-3q)/Mcwi (FHH X FHH-3BN/Mcwi) F2 males were backcrossed with FHH-3BN/Mcwi females to produce offsprings, these were intercrossed to generate this congenic line Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown RRID:RGD_10395251 10395253 FHH.FHH.3BN-(D3Hmgc24-3q)(3p-D3Rat98)/Mcwi (FHH X FHH-3BN/Mcwi) F2 males were backcrossed with FHH-3BN/Mcwi females to produce offsprings, these were intercrossed to generate this congenic line Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 3 30253942 30254280 1 - by flanking markers 3 38636977 38637167 1 - by flanking markers 3 33477354 33477544 1 - by flanking markers 3 33703347 33703538 1 - by flanking markers RRID:RGD_10395253 10395297 GK/FarMcwi Goto-Kakizaki Generated by selective brother x sister breeding of 18 non-diabetic Jcl:Wistar rats which were glucose intolerant on oral glucose tolerant tests. This colony is from F36 generation of the Japanese colony provided by Drs. Suzuki and Toyota of Tokoku University , Sendai Japan. Now bred and maintained at Medical College of Wisconsin Medical College of Wisconsin, Milwaukee, Wisconsin inbred Unknown RRID:RGD_10395297 10401195 SD-Tg(CAG.LoxP.EGFP)Zi Random insertion of a Cre inducible expression cassette, controlled by the CAG promoter. LacZ is expressed constitutively, GFP only after Cre mediated recombination Rat Resource and Research Center transgenic Live Animals; Cryopreserved Sperm; Cryorecovery RRID:RRRC_00689 10401201 LE-Tg(Th-cre)3.1Deis Cre gene was introduced immediately before the ATG of the mouse tyrosine hydroxylase (Th) gene on BAC RP23-350E13 Rat Resource and Research Center transgenic Live Animals; Cryopreserved Sperm (as of 2017-05-31) RRID:RRRC_00659 10401204 LE-Tg(ChAT-cre)5.1DeisRrrc Cre gene was introduced immediately before the ATG of the mouse choline acetyltransferase (Chat) gene in BAC RP23-246B12. This strain is estimated to carry 6 copies of the transgene at the integration site. Rat Resource and Research Center transgenic Live Animals; Cryopreserved Sperm (as of 2017-05-31) RRID:RRRC_00658 10401208 F344-Tg(Prp-APP,Prp-PS1)19/Rrrc The strain was coinjected with two transgenes: one contains the human amyloid beta (A4) precursor protein (hAPP) gene with the Swedish mutation (K595N/M596L) driven by mouse prion promoter (Prp). The other contains the human presenilin 1 gene (PS1) with a deletion of exon 9, also driven by the mouse prion promoter (Prp). Based on segregation patterns, it is believed that the two transgenes have integrated at the same chromosomal site. Rat Resource and Research Center transgenic Live Animals; Cryopreserved Sperm (as of 2019-02-20) RRID:RRRC_00699 10401212 SD-Tg(Thy1.2-NIPA1) Human NIPA1G106R mutation is made by site-directed mutagenesis and then inserted into Thy1.2-promotor cassette. Transgenic vector is injected into fertilized eggs to produce 2 independent lines (A, B) Rat Resource and Research Center transgenic Cryopreserved Sperm; Cryorecovery RRID:RRRC_00700 10401835 WKY.F344-(D17Got91-D17Rat51)/Tja A congenic strain made by introducing a 15 Mbp segment of chromosome 17 from F344/NHsd into WKY/Cruk, this region has the distal end of Cm15 QTL MRC Clinical Centre, London, UK congenic Unknown 17 82277434 96587905 1 - by flanking markers 17 76512697 91678127 1 - by flanking markers 17 74852634 90012722 1 - by flanking markers 17 71003329 85119583 1 - by flanking markers RRID:RGD_10401835 10401837 WKY.F344-(D17Got91-D17Rat47)/Tja A congenic substrain derived from the progenitor strain WKY.F344-(D17Got91-D17Rat51)/Tja MRC Clinical Centre, London, UK congenic Unknown 17 82277434 85072478 1 - by flanking markers 17 76512697 79573336 1 - by flanking markers 17 74852634 77922655 1 - by flanking markers 17 71003329 73951021 1 - by flanking markers RRID:RGD_10401837 10401839 WKY.F344-(D17Rat47-D17Rat51)/Tja A congenic substrain derived from the progenitor strain WKY.F344-(D17Got91-D17Rat51)/Tja MRC Clinical Centre, London, UK congenic Unknown 17 85072352 96587905 1 - by flanking markers 17 79573143 91678127 1 - by flanking markers 17 77922462 90012722 1 - by flanking markers 17 73950871 85119583 1 - by flanking markers RRID:RGD_10401839 10401841 WKY.F344-(D17Rat131-D17Rat51)/Tja A congenic substrain derived from the progenitor strain WKY.F344-(D17Got91-D17Rat51)/Tja MRC Clinical Centre, London, UK congenic Unknown 17 93347783 96587905 1 - by flanking markers 17 87712049 91678127 1 - by flanking markers 17 85994775 90012722 1 - by flanking markers 17 81903264 85119583 1 - by flanking markers RRID:RGD_10401841 10401843 WKY-Slc39a12em77Tja This strain was produced by injecting ZFNs targeted sequence into WKY/Cruk rat embryos. The resulting mutation 77 has a stop codon, 15 amino acids from the ZFN-binding site, that resulted in a 490 amino acids (54 kDa) truncated protein, 198 amino acids smaller than the WT protein. MRC Clinical Centre, London, UK mutant Unknown Slc39a12em77Tja 10401842 17 88525527 88605947 1 - by flanking markers 17 83202775 83288616 1 - by flanking markers 17 81455731 81541742 1 - by flanking markers 17 77353761 77440381 1 - by flanking markers RRID:RGD_10401843 10401845 WKY-Slc39a12em77Tja+/- WKY-Slc39a12em77Tja+/WKY-Slc39a12em77Tja- ZFN mutant founders were backcrossed with WKY/Cruk to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. The resulting mutation 77 has a stop codon, 15 amino acids from the ZFN-binding site, that resulted in a 490 amino acids (54 kDa) truncated protein, 198 amino acids smaller than the WT protein. MRC Clinical Centre, London, UK mutant Unknown Slc39a12em77Tja 10401842 17 88525527 88605947 1 - by flanking markers 17 83202775 83288616 1 - by flanking markers 17 81455731 81541742 1 - by flanking markers 17 77353761 77440381 1 - by flanking markers RRID:RGD_10401845 10401848 WKY-Slc39a12em77Tja-/- WKY-Slc39a12em77Tja-/WKY-Slc39a12em77Tja- ZFN mutant founders were backcrossed with WKY/Cruk to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. The resulting mutation 77 has a stop codon, 15 amino acids from the ZFN-binding site, that resulted in a 490 amino acids (54 kDa) truncated protein, 198 amino acids smaller than the WT protein. MRC Clinical Centre, London, UK mutant Unknown Slc39a12em77Tja 10401842 17 88525527 88605947 1 - by flanking markers 17 83202775 83288616 1 - by flanking markers 17 81455731 81541742 1 - by flanking markers 17 77353761 77440381 1 - by flanking markers RRID:RGD_10401848 10401851 SD-Lepem1Narl CRISPR/Cas9 system was used to generate this mutant. This mutant strain has increased body weight, increased circulating cholesterol level and increased triglyceride level compared to its littermates National Laboratory Animal Center, Taiwan mutant Unknown Lep 3000 4 55943837 55945938 1 - by flanking markers 4 56085079 56099209 1 - by flanking markers 4 56337695 56351818 1 - by flanking markers 4 57661127 57675262 1 - by flanking markers RRID:RGD_10401851 10401918 BDIX/HanHsd BDIX/Han maintained at Envigo (Harlan) Envigo inbred Cryorecovery RRID:RGD_10401918 10402160 HCR/1Mco High-capacity runners; generation 5 HCR/Mco bred till the fifth generation Medical College of Ohio, Toledo, Ohio, USA inbred Unknown RRID:RGD_10402160 10402163 HCR/2Mco High-capacity runners; generation 26 HCR/Mco bred till the twenty-sixth generation Medical College of Ohio, Toledo, Ohio, USA inbred Unknown RRID:RGD_10402163 10402165 LCR/1Mco Low-capacity runners; generation 5 LCR/Mco bred till the fifth generation Medical College of Ohio, Toledo, Ohio, USA inbred Unknown RRID:RGD_10402165 10402167 LCR/2Mco Low-capacity runners; generation 26 LCR/Mco bred till the twenty-sixth generation Medical College of Ohio, Toledo, Ohio, USA inbred Unknown RRID:RGD_10402167 10402390 BNW/Jer Brown Norway-wild This is a wild caught strain, characterized by Charles River Laboratories and has been bred brother x sister Agricultural Omega Solutions LLC, Milwaukee, Wisconsin inbred Unknown RRID:RGD_10402390 10402393 HPE/Jer Hairless pink eye dilute This is a strain of unknown background, and has been bred brother x sister Agricultural Omega Solutions LLC, Milwaukee, Wisconsin inbred Unknown RRID:RGD_10402393 10402395 HBLS/Jer Hairless black skin pigmented This is a result of a cross of the BNW and HPE, this spontaneous hairless black skin mutation was selected from the F2 offspring for the black hairless quality and subsequently bred brother x sister Agricultural Omega Solutions LLC, Milwaukee, Wisconsin inbred Unknown RRID:RGD_10402395 10402819 DA-Tph2em2Mcwi This strain was produced by injecting ZFNs targeting the sequence CATGGCTCCGACCCCctctacACCCCGGAACCG into DA/OlaHsd rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2021-11-03) Tph2em2Mcwi 10402817 7 54321033 54430706 1 - by flanking markers 7 58053268 58157949 1 - by flanking markers 7 58042279 58149220 1 - by flanking markers 7 50685694 50789424 1 - by flanking markers RRID:RGD_10402819 10402822 DA-Tph2em3Mcwi This strain was produced by injecting ZFNs targeting the sequence CATGGCTCCGACCCCctctacACCCCGGAACCG into DA/OlaHsd rat embryos. The resulting mutation is a 11-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Cryorecovery (as of 2017-01-26) Tph2em3Mcwi 10402820 7 54321033 54430706 1 - by flanking markers 7 58053268 58157949 1 - by flanking markers 7 58042279 58149220 1 - by flanking markers 7 50685694 50789424 1 - by flanking markers RRID:RGD_10402822 10402834 LEW.SS-(D7Rat27-D7Mgh1)/Ayd LEW/Crlc and SS/Jr were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 7 32004504 32004684 1 - by flanking markers 7 35931747 35931926 1 - by flanking markers 7 35867729 35867908 1 - by flanking markers 7 29409683 29409863 1 - by flanking markers RRID:RGD_10402834 10402836 LEW.SS-(D8Chm12-D8Rat15)/Ayd LEW/Crlc and SS/Jr were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 8 103548728 103548876 1 - by flanking markers 8 105836600 105836747 1 - by flanking markers 8 106394231 106394378 1 - by flanking markers 8 98968617 98968765 1 - by flanking markers RRID:RGD_10402836 10402839 LEW.SS-(D10Mgh6-D10Mgh1)/Ayd LEW/Crlc and SS/Jr were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 10 67677924 67678060 1 - by flanking markers 10 63366082 63366218 1 - by flanking markers 10 64648175 64648311 1 - by flanking markers 10 61345276 61345413 1 - by flanking markers RRID:RGD_10402839 10402842 LEW.SS-(D17Rat15-D17Rat51)/Ayd LEW/Crlc and SS/Jr were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 17 37727971 96587905 1 - by flanking markers 17 33949701 91678127 1 - by flanking markers 17 32055882 90012722 1 - by flanking markers 17 31368391 85119583 1 - by flanking markers RRID:RGD_10402842 10402850 LEW.SS-(D7Rat27-D7Mgh1)(D17Rat15-D17Rat51)/Ayd double congenic strain was generated by combining the two separate congenic strains Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 17;7 37727971;32004504 96587905;32004684 1 - by flanking markers;1 - by flanking markers 17;7 33949701;35931747 91678127;35931926 1 - by flanking markers;1 - by flanking markers 17;7 32055882;35867729 90012722;35867908 1 - by flanking markers;1 - by flanking markers 7;17 29409683;31368391 29409863;85119583 1 - by flanking markers;1 - by flanking markers RRID:RGD_10402850 10402852 LEW.SS-(D7Rat27-D7Mgh1)(D17Rat15-D17Rat51)(D10Mgh6-D10Mgh1)/Ayd multiple congenic strain was generated by combining the three separate congenic strains Research Centre, Centre Hospitalier de l'Universite de Monteal (CHUM), Quebec, Canada congenic Unknown 17;10;7 37727971;67677924;32004504 96587905;67678060;32004684 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 17;10;7 33949701;63366082;35931747 91678127;63366218;35931926 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 17;10;7 32055882;64648175;35867729 90012722;64648311;35867908 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 17;7;10 31368391;29409683;61345276 85119583;29409863;61345413 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers RRID:RGD_10402852 10412325 LE-Tg(Drd1-icre)3Ottc The transgene expresses BAC transgenic using rat dopamine receptor 1 promoter to express Cre recombinase in D1R neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Live Animals (as of 2019-03-18) Drd1 2518 17 16655926 16658161 1 - by flanking markers 17 13211031 13215581 1 - by flanking markers 17 11099736 11104352 1 - by flanking markers 17 10540440 10544971 1 - by flanking markers RRID:RRRC_00767 10412327 LE-Tg(Drd2-iCre)1Ottc The transgene expresses BAC transgenic using rat dopamine receptor 2 promoter to express Cre recombinase in D2R neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Live Animals (as of 2019-03-18) Drd1 2518 17 16655926 16658161 1 - by flanking markers 17 13211031 13215581 1 - by flanking markers 17 11099736 11104352 1 - by flanking markers 17 10540440 10544971 1 - by flanking markers RRID:RRRC_00768 10412329 LE-Tg(Pvalb-icre)2Ottc The transgene expresses BAC transgenic using rat parvalbumin promoter to express Cre recombinase in parvalbumin expressing neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Live Animals (as of 2019-03-18) Pvalb 3457 RRID:RRRC_00773 10413850 SD-Abcc6em1Qlju-/- This strain was produced by injecting ZFNs into SD embryos. ZFNs were designed to target exon 1 of rat Abcc6 gene at the binding site/cutting site 5-CACGCCTGGAGAGTCCTGcgcaggCCTGAGGGTGAGTCC-3 (c.24-c.62). The resulting mutation is a 10-bp deletion (CAGGCCTGAG)from the first coding exon of the rat Abcc6 gene. The mutation is predicted to cause out of frame translation and a premature stop codon. No protein in the homozygous mutant was detected by immunostaining. Thomas Jefferson University, Philadelphia mutant Unknown Abcc6em1Qlju 10413843 1 96448588 96524655 1 - by flanking markers 1 103042723 103096453 1 - by flanking markers 1 101954786 102013252 1 - by flanking markers 1 96447224 96501464 1 - by flanking markers RRID:RGD_10413850 10413852 SD-Abcc6em2Qlju-/- This strain was produced by injecting ZFNs into SD embryos. ZFNs were designed to target exon 1 of rat Abcc6 gene at the binding site/cutting site 5-CACGCCTGGAGAGTCCTGcgcaggCCTGAGGGTGAGTCC-3 (c.24-c.62). The resulting mutation is a 23 bp-deletion (TGCGCAGGCCTGAGGGTGAGTCC) from the first coding exon of the rat Abcc6 gene. The mutation is predicted to cause out of frame translation and a premature stop codon. No protein in the homozygous mutant was detected by immunostaining. Thomas Jefferson University, Philadelphia mutant Unknown Abcc6em2Qlju 10413846 1 96448588 96524655 1 - by flanking markers 1 103042723 103096453 1 - by flanking markers 1 101954786 102013252 1 - by flanking markers 1 96447224 96501464 1 - by flanking markers RRID:RGD_10413852 10413854 SD-Abcc6em3Qlju-/- This strain was produced by injecting ZFNs into SD embryos. ZFNs were designed to target exon 1 of rat Abcc6 gene at the binding site/cutting site 5-CACGCCTGGAGAGTCCTGcgcaggCCTGAGGGTGAGTCC-3 (c.24-c.62). The resulting mutation is a 10-bp deletion (CAGGCCTGAG)from the first coding exon of the rat Abcc6 gene. The mutation is predicted to cause out of frame translation and a premature stop codon. No protein in the homozygous mutant was detected by immunostaining. Thomas Jefferson University, Philadelphia mutant Unknown Abcc6em3Qlju 10413847 1 96448588 96524655 1 - by flanking markers 1 103042723 103096453 1 - by flanking markers 1 101954786 102013252 1 - by flanking markers 1 96447224 96501464 1 - by flanking markers RRID:RGD_10413854 10413856 SD-Abcc6em4Qlju-/- This strain was produced by injecting ZFNs into SD embryos. ZFNs were designed to target exon 1 of rat Abcc6 gene at the binding site/cutting site 5-CACGCCTGGAGAGTCCTGcgcaggCCTGAGGGTGAGTCC-3 (c.24-c.62). The resulting mutation is a 20-bp deletion from cDNA position 30-49 (GAGAGTCCTGCGCAGGCCTG). The mutation is predicted to cause out of frame translation and a premature stop codon. No protein in the homozygous mutant was detected by immunostaining. Thomas Jefferson University, Philadelphia mutant Unknown Abcc6em4Qlju 10413848 1 96448588 96524655 1 - by flanking markers 1 103042723 103096453 1 - by flanking markers 1 101954786 102013252 1 - by flanking markers 1 96447224 96501464 1 - by flanking markers RRID:RGD_10413856 10413858 SD-Abcc6em5Qlju-/- This strain was made by ZFN mutagenesis. ZFNs were designed to target exon 1 of rat Abcc6 gene at the binding site/cutting site 5-CACGCCTGGAGAGTCCTGcgcaggCCTGAGGGTGAGTCC-3 (c.24-c.62). The resulting mutation is a 11-bp deletion from cDNA position 39-49 (CTGCGCAGGCC). The mutation is predicted to cause out of frame translation and a premature stop codon. No protein in the homozygous mutant was detected by immunostaining. Thomas Jefferson University, Philadelphia mutant Unknown Abcc6em5Qlju 10413849 1 96448588 96524655 1 - by flanking markers 1 103042723 103096453 1 - by flanking markers 1 101954786 102013252 1 - by flanking markers 1 96447224 96501464 1 - by flanking markers RRID:RGD_10413858 10450489 SD-Bsnem1Ionsz CRISPR/Cas9 system was used to generate this mutant; sgRNA+Cas9+ plasmid was injected into zygote of SD rat that added a 2a-NpHR-EYFP-2a-ChR2-mcherry-ires-WGA-cre behind the last exon of Bsn Institute of Neuroscience, Chinese Academy of Sciences mutant Unknown Bsnem1Ionsz 10450488 8 113364208 113455766 1 - by flanking markers 8 116227802 116319071 1 - by flanking markers 8 116873721 116965396 1 - by flanking markers 8 108784849 108875819 1 - by flanking markers RRID:RGD_10450489 10755350 F344.ZUC-(Leprfa),OLETF-(D14Rat23-D14Rat12)/Tj The F344.ZUC,OLETF double congenic was produced by crossing F344.ZUC-Leprfa with F344.OLETF-( D14Rat23-D14Rat12) and then selecting Leprfa -Niddm20 (fa/fa-Nidd2/of) homozygotes National BioResource Project for the Rat in Japan congenic Unknown Diabetes Obesity Lepr 3001 14;5 1764386;122320075 41707592;122503449 1 - by flanking markers;1 - by flanking markers 14;5 2222207;124380327 61886417;124556585 1 - by flanking markers;1 - by flanking markers 14;5 2227825;120503475 61783215;120682281 1 - by flanking markers;1 - by flanking markers 5;14 116294409;1217606 116477904;39153750 1 - by flanking markers;1 - by flanking markers RRID:RGD_10755350 10755352 LH/MavRrrcAek Lyon Hypertensive Lyon Hypertensive rats maintained at Department of Pharmacology, University of Iowa Department of Pharmacology, University of Iowa, Iowa inbred Unknown RRID:RGD_10755352 10755354 LN/MavRrrcAek lyon normotensive Lyon normotensive rats maintained at Department of Pharmacology, University of Iowa Department of Pharmacology, University of Iowa, Iowa inbred Unknown RRID:RGD_10755354 11040455 SHR.BN-(D16Rat88-D16Rat9)/Cub Segment of chromosome 16 from BN.Lx/Cub was transferred to SHR/Ola after 9 backcrosses an intercross was done to obtain the desired congenic Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic congenic Unknown 16 819225 22577050 1 - by flanking markers 16 1534408 22473610 1 - by flanking markers 16 1550187 22579213 1 - by flanking markers 16 832236 20872425 1 - by flanking markers RRID:RGD_11040455 11040519 SHR-Ndufc2em1Mcwi-/+ SHR-Ndufc2em1Mcwi-/Ndufc2em1Mcwi+ ZFN mutant founders were backcrossed with SHR/NCrl to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown Ndufc2em1Mcwi 9588537 1 154635889 154642112 1 - by flanking markers 1 168576274 168582497 1 - by flanking markers 1 162369801 162376024 1 - by flanking markers 1 151711965 151718188 1 - by flanking markers RRID:RGD_11040519 11040521 SHR-Ndufc2em2Mcwi-/+ SHR-Ndufc2em2Mcwi-/Ndufc2em2Mcwi+ ZFN mutant founders were backcrossed with SHR/NCrl to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_11040521 11040525 SHR-Ndufc2em1Mcwi+/+ SHR-Ndufc2em1Mcwi+/Ndufc2em1Mcwi+ ZFN mutant founders were backcrossed with SHR/NCrl to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_11040525 11040527 SHR-Ndufc2em2Mcwi+/+ SHR-Ndufc2em2Mcwi+/Ndufc2em2Mcwi+ ZFN mutant founders were backcrossed with SHR/NCrl to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Unknown RRID:RGD_11040527 11040548 CrlCembe:WI Wistar rats CeMBE received breeding stock from Charles River (Crl:WI, strain code 003) in 2014, these are bred according to the Poiley rotation (1960) with permanent monogamous mating. Center for Biological Model Research (CeMBE), Pontifical Catholic University from Rio Grande do Sul (PUCRS), Brazil outbred Unknown RRID:RGD_11040548 11040561 WI-Htr7em1Geh CRISPR/Cas9 system was used to generate this mutant; this induced 89 base pair deletion in exon 1 of the Htr7 gene. Rat Resource and Research Center mutant Cryopreserved Sperm; Cryorecovery Htr7em1Geh 14696714 1 240136279 240260620 1 - by flanking markers 1 261759122 261879914 1 - by flanking markers 1 254547964 254671811 1 - by flanking markers 1 233636442 233761063 1 - by flanking markers RRID:RRRC_00745 11040563 SD-Tg(Adra1a)Vccr Cardiac specific overexpression of the alpha 1A adrenergic receptor, 40 fold overexpression of the receptor Rat Resource and Research Center transgenic Unknown RRID:RRRC_00756 11040565 LEW-Tg(CAG-OFP)Pic random insertion of a transgene carrying orange fluorescent protein (OFP) driven by the CAG promoter Rat Resource and Research Center transgenic Cryopreserved Sperm; Cryorecovery RRID:RRRC_00746 11040568 W-Tg(RNB1-116K03-EGFP-mRFP)3Kyo The transgene consists of the bacterial artificial chromosome (BAC) clone RNB1-116, which contains the attractin (Atrn) gene which is modified by in-frame insertion of the EGFP reporter gene upstream of the 29th exon and an in-frame insertion of the mRFP reporter gene between 24th exon and stop codon. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Atrn 69063 3 118539268 118701177 1 - by flanking markers 3 129934303 130067267 1 - by flanking markers 3 123434409 123567922 1 - by flanking markers 3 118110320 118244326 1 - by flanking markers RRID:RGD_11040568 11040570 W-Tg(RNB1-116K03-EGFP-mRFP)20Kyo The transgene consists of the bacterial artificial chromosome (BAC) clone RNB1-116, which contains the attractin (Atrn) gene which is modified by in-frame insertion of the EGFP reporter gene upstream of the 29th exon and an in-frame insertion of the mRFP reporter gene between 24th exon and stop codon. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Atrn 69063 3 118539268 118701177 1 - by flanking markers 3 129934303 130067267 1 - by flanking markers 3 123434409 123567922 1 - by flanking markers 3 118110320 118244326 1 - by flanking markers RRID:RGD_11040570 11040572 W-Tg(RNB1-116K03-EGFP-mRFP)21Kyo The transgene consists of the bacterial artificial chromosome (BAC) clone RNB1-116, which contains the attractin (Atrn) gene which is modified by in-frame insertion of the EGFP reporter gene upstream of the 29th exon and an in-frame insertion of the mRFP reporter gene between 24th exon and stop codon. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Atrn 69063 3 118539268 118701177 1 - by flanking markers 3 129934303 130067267 1 - by flanking markers 3 123434409 123567922 1 - by flanking markers 3 118110320 118244326 1 - by flanking markers RRID:RGD_11040572 11040574 W-Tg(RNB1-116K03-EGFP-mRFP)22Kyo The transgene consists of the bacterial artificial chromosome (BAC) clone RNB1-116, which contains the attractin (Atrn) gene which is modified by in-frame insertion of the EGFP reporter gene upstream of the 29th exon and an in-frame insertion of the mRFP reporter gene between 24th exon and stop codon. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Atrn 69063 3 118539268 118701177 1 - by flanking markers 3 129934303 130067267 1 - by flanking markers 3 123434409 123567922 1 - by flanking markers 3 118110320 118244326 1 - by flanking markers RRID:RGD_11040574 11040577 W-Tg(RNB1-116K03-EGFP-mRFP)41Kyo The transgene consists of the bacterial artificial chromosome (BAC) clone RNB1-116, which contains the attractin (Atrn) gene which is modified by in-frame insertion of the EGFP reporter gene upstream of the 29th exon and an in-frame insertion of the mRFP reporter gene between 24th exon and stop codon. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Atrn 69063 3 118539268 118701177 1 - by flanking markers 3 129934303 130067267 1 - by flanking markers 3 123434409 123567922 1 - by flanking markers 3 118110320 118244326 1 - by flanking markers RRID:RGD_11040577 11040579 W-Tg(RNB1-116K03-EGFP-mRFP)104Kyo The transgene consists of the bacterial artificial chromosome (BAC) clone RNB1-116, which contains the attractin (Atrn) gene which is modified by in-frame insertion of the EGFP reporter gene upstream of the 29th exon and an in-frame insertion of the mRFP reporter gene between 24th exon and stop codon. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Atrn 69063 3 118539268 118701177 1 - by flanking markers 3 129934303 130067267 1 - by flanking markers 3 123434409 123567922 1 - by flanking markers 3 118110320 118244326 1 - by flanking markers RRID:RGD_11040579 11040581 TRM.W-Tg(RNB1-186G14)51Kyo F344/Stm rat BAC clone RNB1-186G14 was microinjected into embryos of Wistar rats. The founder rats were backcrossed to TRM/Kyo rats. BAC vector:pKS145. RNB1-186G14 contains region between 60185236-60354841 of Rat Chr 10 and this region contains Spata22 gene expressed in testes. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_11040581 11040675 TRM.W-Tg(RNB1-186G14)33Kyo F344/Stm rat BAC clone RNB1-186G14 was microinjected into embyos of Wistar rats. The founder rats were backcrossed to TRM/Kyo rats. BAC vector:pKS145. RNB1-186G14 contains region between 60185236-60354841 of Rat Chr 10 and this region contains Spata22 gene expressed in testes. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_11040675 11040678 TRMR.W-Tg(RNB1-186G14)51Kyo F344/Stm rat BAC clone RNB1-186G14 was microinjected into embyos of Wistar rats. The founder rats were backcrossed to TRM/Kyo rats. BAC vector:pKS145. RNB1-186G14 contains region between 60185236-60354841 of Rat Chr 10 and this region contains Spata22 gene expressed in testes. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_11040678 11040681 TRMR.W-Tg(RNB1-186G14)33Kyo F344/Stm rat BAC clone RNB1-186G14 was microinjected into embyos of Wistar rats. The founder rats were backcrossed to TRM/Kyo rats. BAC vector:pKS145. RNB1-186G14 contains region between 60185236-60354841 of Rat Chr 10 and this region contains Spata22 gene expressed in testes. National BioResource Project for the Rat in Japan transgenic Live Animals; Cryopreserved Sperm RRID:RGD_11040681 11040683 SER.TRMR.W-Tg(RNB1-186G14)51Kyo The sperms from N2 generation rat (ID#252) of TRMR.W-Tg(RNB1-186G14)51Kyo (NBRP-Rat#0677) were microinjected into SER embyos. The offspring with transgese was backcrossed with SER rats. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_11040683 11040916 F344-Zeb2em1Kyo Zinc-finger nucleases (ZFNs) method taregting exon 5 of Zeb2 gene (AGCCAAAGCTTGCCTCCA and GACTACTGACTCAAG) was used; This strain has a 5-bp deletion (cagag) and a 2-bp insertion (tc) in exon7 of Nrf2 gene, resulting in a deletion of Glutamine(Q)541. Background strain: F344/Stm National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Neurobiology; Development Zeb2 1307272 RRID:RGD_11040916 11040918 WTC-furue/Kyo WTC-furue rat was found in a colony of WTC.ZI-Atrn congenic strain at national cancer research center in 2000. The tremor phenotype is controlled by an autosomal recessive mutation ("furue") National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Neurobiology RRID:RGD_11040918 11040920 WTC.Cg-dmyTg(Mrs2-EGFP)39Kyo CHORI230-9K13 recombinant BAC (Mrs2/EGFP) was introduced into Crlj:Wistar embyos. BAC Tg rats were backcrossed with WTC.DMY-dmy. dmy gene: homozygous, transgene: hemizygous. 4 lines: #15, #39, #92, #131 National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_11040920 11040922 WTC.Cg-dmyTg(Mrs2-EGFP)15Kyo CHORI230-9K13 recombinant BAC (Mrs2-EGFP) was introduced into Crlj:Wistar embyos. BAC Tg rats were backcrossed with WTC.DMY-dmy. dmy gene: homozygous, transgene: hemizygous. 4 lines: #15, #39, #92, #131 National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_11040922 11040934 WTC.Cg-dmyTg(Mrs2-EGFP)92Kyo CHORI230-9K13 recombinant BAC (Mrs2-EGFP) was introduced into Crlj:Wistar embyos. BAC Tg rats were backcrossed with WTC.DMY-dmy. dmy gene: homozygous, transgene: hemizygous. 4 lines: #15, #39, #92, #131 National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_11040934 11040936 WTC.Cg-dmyTg(Mrs2-EGFP)131Kyo CHORI230-9K13 recombinant BAC (Mrs2/EGFP) was introduced into Crlj:Wistar embyos. BAC Tg rats were backcrossed with WTC.DMY-dmy. dmy gene: homozygous, transgene: hemizygous. 4 lines: #15, #39, #92, #131 National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_11040936 11040939 STOCK.dmyTg(CMV-Mrs2)Kyo A transgene containing the CMV promoter and MRS2 gene was microinjected into the pronuclei of fertilized oocytes collected from Wistar rats. Transgenic offspring founder rats were backcrossed with WTC.DMy-dmy rats to obtain dmy/dmy homozygous and also hemizygous for the transgede (dmy/dmy, tg/+). National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Mrs2 708529 RRID:RGD_11040939 11040941 SD-Tg(Gfap-Tk1)Jog SD-Tg(Gfap-Tk1) The rats were originally generated by the University of Michigan Transgenic Animal Model Core, University of Michigan. They used a Crl:CD(SD) sub strain of Sprague-Dawley rats, obtained from Charles River Laboratory (Wilmington, MA, USA). The F1 rats have been bred in the UK with Hsd:Sprague Dawley (Harlan laboratories, UK), which are direct descendants of the original 1925 SD-company colony (Madison, Wisconsin, USA). The GFAP-TK rat was generated by pronuclear injection of a Gfap-Tk Bacterial Artificial Chromosome (BAC) construct, engineered using RedET-mediated homologous recombination methods. National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo Gfap|Tk1 2679|621014 RRID:RGD_11040941 11040946 F344-Prkdcem1Kyo This strain was established by Zinc-finger nucleases (ZFNs) method taregting exon1 of rat Prkdc gene, resulting a 46-deletion. Background strain: F344/Stm National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2017-06-08) Prkdc|Prkdcem1Kyo 1308982|12910095 11 86951420 87169229 1 - by flanking markers 11 92347175 92565022 1 - by flanking markers 11 89293547 89510948 1 - by flanking markers 11 85040790 85258357 1 - by flanking markers RRID:RGD_11040946 11040948 F344-Prkdcem2KyoIl2rgem6Kyo This strain was established by Zinc-finger nucleases (ZFNs) method taregting rat Prkdc gene (227-bp deletion) and Il2rg gene (332-bp deletion). Background strain: F344/Stm National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2017-06-08) Il2rg|Prkdc|Prkdcem2Kyo|Il2rgem6Kyo 621466|1308982|12910096|12910097 11;X 86951420;89342055 87169229;89345715 1 - by flanking markers;1 - by flanking markers 11;X 92347175;72017856 92565022;72021516 1 - by flanking markers;1 - by flanking markers X;11 71165378;89293547 71169078;89510948 1 - by flanking markers;1 - by flanking markers 11;X 85040790;66395330 85258357;66399026 1 - by flanking markers;1 - by flanking markers RRID:RGD_11040948 11040950 TM-Prkdcem4KyoIl2rgem5Kyo This strain was established by Zinc-finger nucleases (ZFNs) method causing 20-bp deletion in the exon1 of Prkdc gene and a 653-bp deletion Il2rg gene. Background strain: TM/Kyo National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2017-07-12) Il2rg|Prkdc|Prkdcem4Kyo|Il2rgem5Kyo 621466|1308982|12910098|12910099 11;X 86951420;89342055 87169229;89345715 1 - by flanking markers;1 - by flanking markers 11;X 92347175;72017856 92565022;72021516 1 - by flanking markers;1 - by flanking markers X;11 71165378;89293547 71169078;89510948 1 - by flanking markers;1 - by flanking markers 11;X 85040790;66395330 85258357;66399026 1 - by flanking markers;1 - by flanking markers RRID:RGD_11040950 11040952 WKY.SHRSP-(D1Mgh5-D1Arb21)(D3Mgh16-D3Rat144)/Izm A congenic strain made by introducing a segments of chromosome 1 and 3 from SHRSP/Izm into WKY/Izm. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo; Cryopreserved Sperm 1;3 78134304;6373335 187092492;151449116 1 - by flanking markers;1 - by flanking markers 1;3 80946174;11361699 206277202;162886090 1 - by flanking markers;1 - by flanking markers 1;3 79689548;6000748 199254774;156656443 1 - by flanking markers;1 - by flanking markers 1;3 78430536;10778704 182418476;149313851 1 - by flanking markers;1 - by flanking markers RRID:RGD_11040952 11040954 LEA-Tp53tm1(AmCyan1)Ncco LEA rats were provided from Kyoto Bioresource Center in 2006. Then LEA rat ES cells having Oct4-Venus gene and Oct4-Venus Tg rat strain (LEA-Tg(Pou5f1-YFP*)3Ncco) were established. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo RRID:RGD_11040954 11040957 F344-Tp53m1Kyo This strain was established by ENU mutagenesis (gene-driven) using F344/NSlc and has a missense mutation（R271C). National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm Tp53|Tp53m1Kyo 3889|12792955 10 56399721 56411150 1 - by flanking markers 10 55932658 55944087 1 - by flanking markers 10 56186299 56198449 1 - by flanking markers 10 54300070 54311525 1 - by flanking markers RRID:RGD_11040957 11040959 SER.TRMR.W-tmTRMAtrnziTg(RNB1-186G14)/Kyo The sperms from N2 generation rat (NBRP Rat No:252) of TRMR.W-Tg(RNB1-186G14)51Kyo (NBRP Rat No:0677) were microinjected into SER embryos. The offspring with transgene was backcrossed with SER rats. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_11040959 11040962 F344-Bscl2m1Kyo T239A mutation was found by screening of 4608DNA sample from ENU mutagenesis library KURMA. This strain has a T239A (L80X) nonsense mutation in Bscl2 gene. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2019-01-09) Bscl2|Bscl2m1Kyo 1308135|13838727 1 211509675 211518963 1 - by flanking markers 1 231972073 231983764 1 - by flanking markers 1 225035956 225046137 1 - by flanking markers 1 205731814 205743430 1 - by flanking markers RRID:RGD_11040962 11040969 DWH/Iet Dwarfism derived from Wistar Hannover GALAS rats derived from Wistar Hannover GALAS rats National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo Metabolism Tg 3848 7 104035776 104220754 1 - by flanking markers 7 107399165 107602400 1 - by flanking markers 7 107467260 107652897 1 - by flanking markers 7 98418293 98603210 1 - by flanking markers RRID:RGD_11040969 11040971 F344-TyrCKitH/Kyo 1) point mutation in the exon 2 (896G>A, p.R229H) of Tyrosinase (Tyr) gene (albino phenotype) and 2) retrotransposon insertion (7-bp) in kit gene (hooded phenotype) were targeted by CRISPR/Cas9 system using ssODN. The rat coat colour phenotype was changed from white to black. Background strain: F344/Stm National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm (as of 2017-07-17) Kit|Tyr 620568|1589755 14;1 34906043;143641257 34984819;143746315 1 - by flanking markers;1 - by flanking markers 14;1 34901860;157322968 34979384;157416594 1 - by flanking markers;1 - by flanking markers 14;1 35072131;151012598 35149638;151106802 1 - by flanking markers;1 - by flanking markers 1;14 141115036;32547459 141210207;32624694 1 - by flanking markers;1 - by flanking markers RRID:RGD_11040971 11040974 F344-AsipATyrCKitH/Kyo 1) point mutation in the exon 2 of Tyrosinase (Tyr) gene (albino phenotype), 2) 19-bp deletion in Asip gene (Agouti phenotype), and 3) retrotransposon insertion (7-bp) in kit gene (hooded phenotype) were targeted by CRISPR/Cas9 system using ssODN. The rat coat colour phenotype was changed from white to Agouti. Background strain: F344/Stm National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm Asip|Kit|Tyr 2003|620568|1589755 3;14;1 145445175;34906043;143641257 145536831;34984819;143746315 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 14;3;1 34901860;156860395;157322968 34979384;156949277;157416594 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 3;14;1 150492010;35072131;151012598 150579870;35149638;151106802 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 3;1;14 143473584;141115036;32547459 143561170;141210207;32624694 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers RRID:RGD_11040974 11040977 WI-ROSA26em1(CAG-EGFP)Kyo CAG-GFP vector was knock-in into the rat Rosa26 locus by CRISPR/Cas9 system. Background strain: Crlj:WI National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2017-08-08) RRID:RGD_11040977 11040980 W-Dmdem2Kykn By CRISPR/Cas9 system, mutation was introduced in dystrophin (Dmd) gene of Wistar-Imamichi rat: deletion of exon3 to exon16 National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2017-05-02) Dmd 2507 X 71501362 71671414 1 - by flanking markers X 51475950 53700033 1 - by flanking markers X 51149358 53519271 1 - by flanking markers X 47272324 49504219 1 - by flanking markers RRID:RGD_11040980 11040985 W-Dmdem3Kykn By CRISPR/Cas9 system, mutation was introduced in dystrophin (Dmd) gene of Wistar-Imamichi rat: Deletion of exon3 to exon16 (a part of intron 3 remain). This straindied out in 2015. National BioResource Project for the Rat in Japan mutant Extinct (as of 2017-05-02) Dmd 2507 X 71501362 71671414 1 - by flanking markers X 51475950 53700033 1 - by flanking markers X 51149358 53519271 1 - by flanking markers X 47272324 49504219 1 - by flanking markers RRID:RGD_11040985 11040987 WIC-Tg(Nanog-YFP*)1Utr BAC (containing rat Nanog gene) vector was injected into Iar:Wistar-Imamichi rats. The construct is as follows: Venus-IRES-puromycin resistance gene. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2017-04-21) Nanog 1303178 RRID:RGD_11040987 11041106 LE-Tg(Pvalb-tTA)15Hio background strain #65306; Long-Evans rat #65288; Iar:Long-Evans #65289; Transgene #65306; (1) Parvalbumin (PV) promoter #65306; mouse derived (MGI:97821). PV is calcium-binding protein. (2) tetracycline transactivator (tTA) #65306; Fusion protein of tetracycline repressor (Escherichia coli-derived) and VP16 (Herpes simplex virus-derived). In the absence of Doxycycline (Dox), tTA binds to tetracycline-responsive element (TRE) and expression of TRE-controlled genes can be induced. Vector #65306; pBlueScript (Stratagene), pBACe3.6 (CHORI) National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm RRID:RGD_11041106 11041108 CV/Iet The Laboratory of Reproductive Toxicology at the Institute of Environmental Toxicology has been maintaining a Wistar derived PD strain of rats. In 1986, 1 female and 2 males exhibiting very short and sparse vibrissae were found in a litter of 7 parented by a pd/pd female and phenotypically normal pd/+ male. In 2008, a male Wistar rat and F56 female were crossed, and obtained heterozygous rats were sib-mated. After that, sib mating between homozygous rats was started. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm RRID:RGD_11041108 11041128 TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo The Cblb mutation, one of the causative gene in type 1 diabetes of KDP/Tky and KDP alleles in other modifier genes were transferred onto the genetic background of TM:Kyo strain. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm Diabetes Obesity Cblb 620535 RRID:RGD_11041128 11041139 F344-Tg(Dct-lacZ)9Kyo The construct was made by connecting a 3,659 bp DNA fragment of rat Dct (dopachrome tautomerase) gene (5'-3237 to 422) with the upstream of lacZ gene. Dct gene was derived from F344/Stm. Background strain: F344/NSlc, plasmid: pLacZ-Basic (Clontech Laboratories) National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm Development Dct 1564975 RRID:RGD_11041139 11041143 PL/Iet A new mutant gene that causes preaxial polydactyl in the hindlimbs was found in the Jcl:Wistar -derived strain of rats with fused pulmonary lobes (FRL) at the Laboratory of Reproductive Toxicology at the Institute of Environmental Toxicology . Genetic analysis has revealed that the new mutation is not closely linked with the fpl gene. This strain was established by sib mating (over 20 generations). National BioResource Project for the Rat in Japan inbred Cryopreserved Sperm Development RRID:RGD_11041143 11049145 SD-Crhem1Ionsz CRISPR/Cas9 system was used to generate this mutant; sgRNA+Cas9+ plasmid was injected into zygote of SD rat that added a GFP-Cre-2A behind the last exon of Crh. Institute of Neuroscience, Chinese Academy of Sciences mutant Unknown Crhem1Ionsz 11049142 2 104764023 104765887 1 - by flanking markers 2 124182919 124184783 1 - by flanking markers 2 104459999 104461863 1 - by flanking markers 2 102143055 102144919 1 - by flanking markers RRID:RGD_11049145 11073612 SS-Chr 13BN-Mir29bem1Mcwi This strain was produced by injecting TALENs targeting the sequence TTTAAATAGTGATTGTCtagcaccatttgaaaTCAGTGTTCTTGGTGGA into SS-Chr 13BN/mcwi rat embryos. The resulting mutation is a 4-bp deletion in the mature rno-mir-29b-1-3p sequence PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2021-11-03) Mir29b1em1Mcwi 11073608 4 58100053 58100133 1 - by flanking markers 4 58344310 58344390 1 - by flanking markers 4 59650987 59651067 1 - by flanking markers RRID:RGD_11073612 11073719 SD-Drd1em1Ionsz CRISPR/Cas9 system was used to generate this mutant; sgRNA+Cas9+ plasmid was injected into zygote of SD rat that added a 2A-Chr2-EYFP behind the stop codon of Drd1. Institute of Neuroscience, Chinese Academy of Sciences mutant Unknown Drd1em1Ionsz 11073717 17 16655926 16658161 1 - by flanking markers 17 13211031 13215581 1 - by flanking markers 17 11099736 11104352 1 - by flanking markers 17 10540440 10544971 1 - by flanking markers RRID:RGD_11073719 11081142 SD-Pgrem1Soar Crispr/Cas9 targeting of Exon 3 of rat Pgr gene resulting in a deletion of Exon3 Rat Resource and Research Center mutant Unknown reproduction, neurobiology, and cancer Pgr 3317 8 5784717 5845901 1 - by flanking markers 8 7113895 7172761 1 - by flanking markers 8 7128656 7187796 1 - by flanking markers 8 6073216 6131552 1 - by flanking markers RRID:RRRC_00741 11081149 SD-Esr2em1Soar Zinc finger nuclease targeting of exon 4 of the rat estrogen receptor-2 gene resulting in the deletion of exon 4 Rat Resource and Research Center mutant Unknown reproduction Esr2em1Soar 40902840 6 98691167 98775299 1 - by flanking markers 6 108576398 108626196 1 - by flanking markers 6 99163953 99214711 1 - by flanking markers 6 94858438 94909630 1 - by flanking markers RRID:RRRC_00742 11081151 WI-Grm8em1Geh CRISPR/Cas9 induced 29 base pair deletion in exon 1 Rat Resource and Research Center mutant Unknown neurologic medications, neurologic diseases, normal brain functions Grm8 619858 4 53976781 54902331 1 - by flanking markers 4 54226315 55151544 1 - by flanking markers 4 54474344 55409526 1 - by flanking markers 4 55805762 56731690 1 - by flanking markers RRID:RRRC_00744 11081153 SD-Tg(DIO--iRFP)9Ottc The transgene contains Cre recombinase reporter rat expressing the red fluorescent protein gene (iRFP) driven by the EF1 alpha promoter. Optogenetics and Transgenic Technology Core, Rat Resource and Research Center transgenic Live Animals (as of 2019-02-26) RRID:RRRC_00748 11081177 F344tl toothless (tl) A spontaneous tooth less mutation was maintained in inbred Fisher colony maintained at the University of Massachusetts Medical School. The homozygous mutant is a 10-bp insertion near the beginning of the open reading of the Csf1 gene that yields a truncated, nonfunctional protein and an early stop codon. Rat Resource and Research Center mutant Unknown skeletal and osteoclast biology Csf1tl 12910954 2 203292765 203307968 1 - by flanking markers 2 229989430 230017945 1 - by flanking markers 2 210522370 210550546 1 - by flanking markers 2 195377215 195396608 1 - by flanking markers RRID:RRRC_00749 11084925 SD-Tg(CD59-HBA1)Bryd Transgene: human CD59 gene (cDNA) under control of alpha-globin regulatory elements (alpha-globin promoter and alpha hemoglobin locus control region). Upon administration of intermedilysin (ILY), cells expressing human CD59 will be selectively ablated Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2017-01-26) intravascular hemolysis and related sequelae of anemia, hemoglobinemia, and hemoglobinuria CD59 736600 RRID:RRRC_00754 11084928 WKY-Jundem1Tja The mutation was generated using zinc finger nuclease technology. The mutation involves insertion of one extra C at position 16:20486368 in the intronless JunD gene (Rat (Rnor_6.0)Ensembl) resulting in a null mutation. Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) leukemia, breast cancer Jundem1Tja 11084926 16 19239694 19241529 1 - by flanking markers 16 20342096 20343775 1 - by flanking markers 16 20485028 20486707 1 - by flanking markers 16 18734121 18735799 1 - by flanking markers RRID:RRRC_00755 11084931 SD-Tg(RIP7-RLuc-YFP)Vpoit Transgene: RIP7-RLuc-YFP. This transgene expresses a renilla luciferase-YFP fusion protein under control of the rat insulin 2 gene promoter (RIP7). Rat Resource and Research Center transgenic Unknown RRID:RRRC_00757 11087549 LE-Tg(GFAP-TK)Hcam random insertion of human GFAP promoter driving herpes simples virus thymidine kinase Rat Resource and Research Center transgenic Unknown neurogenesis RRID:RRRC_00764 11087551 SD-Il15em1Soar Zinc finger nuclease mediated 7bp deletion within exon 2 of the Il15 gene, resulting in a frameshift and premature stop codon. Rat Resource and Research Center mutant Unknown Il15|Il15em1Soar 2887|12910491 19 27487268 27498973 1 - by flanking markers 19 34532033 34598725 1 - by flanking markers 19 23542606 23624366 1 - by flanking markers 19 25640013 25706818 1 - by flanking markers RRID:RRRC_00769 11087553 SD-Mmp12em1Soar TALEN mediated 664 bp deletion that includes exon 2 of the Mmp12 gene, resulting in a frameshift and premature stop codon Rat Resource and Research Center mutant Cryopreserved Sperm; Cryorecovery (as of 2017-08-10) allergy and lung responses and blood coagulation Mmp12|Mmp12em1Soar 620195|12910500 8 4249938 4259675 1 - by flanking markers 8 5610392 5620294 1 - by flanking markers 8 5594717 5616494 1 - by flanking markers 8 4581785 4591687 1 - by flanking markers RRID:RRRC_00770 11354901 SS.SHR-(D9Mco110-D9Mco124)/Bj This is a congenic substrain developed by crossing SS.SHR-(D9Rat7-D9Rat84)/Mco to SS/Jr and the F1 were intercrossed to produce an F2 population,which was genotyped using microsatellite markers. The selected recombinant rats were crossed to SS/Jr again to duplicate the recombinant region. University of Toledo College of Medicine and Life Sciences congenic Unknown 9 86987972 89709209 1 - by flanking markers 9 94881322 97361568 1 - by flanking markers 9 95162214 97679852 1 - by flanking markers 9 88698037 91114199 1 - by flanking markers RRID:RGD_11354901 11354903 SS.SHR-(D9Mco110-D9Mco121)/Bj This is a congenic substrain developed by crossing SS.SHR-(D9Rat7-D9Rat84)/Mco to SS/Jr and the F1 were intercrossed to produce an F2 population,which was genotyped using microsatellite markers. The selected recombinant rats were crossed to SS/Jr again to duplicate the recombinant region. University of Toledo College of Medicine and Life Sciences congenic Unknown 9 86987972 89541777 1 - by flanking markers 9 94881322 97223353 1 - by flanking markers 9 95162214 97532584 1 - by flanking markers 9 88698037 90976105 1 - by flanking markers RRID:RGD_11354903 11354924 SS.SHR-(D9Mco113-D9Mco124)/Bj This is a congenic substrain developed by crossing SS.SHR-(D9Rat7-D9Rat84)/Mco to SS/Jr and the F1 were intercrossed to produce an F2 population,which was genotyped using microsatellite markers. The selected recombinant rats were crossed to SS/Jr again to duplicate the recombinant region. University of Toledo College of Medicine and Life Sciences congenic Unknown 9 87225627 89709209 1 - by flanking markers 9 95118069 97361568 1 - by flanking markers 9 95430880 97679852 1 - by flanking markers 9 91113977 91114199 1 - by flanking markers RRID:RGD_11354924 11354926 SS.SHR-(D9Mco110-D9Got111)/Bj This is a congenic substrain developed by crossing SS.SHR-(D9Rat7-D9Rat84)/Mco to SS/Jr and the F1 were intercrossed to produce an F2 population,which was genotyped using microsatellite markers. The selected recombinant rats were crossed to SS/Jr again to duplicate the recombinant region. University of Toledo College of Medicine and Life Sciences congenic Unknown 9 86987972 89249893 1 - by flanking markers 9 94881322 96967940 1 - by flanking markers 9 95162214 97276310 1 - by flanking markers 9 88698037 90720113 1 - by flanking markers RRID:RGD_11354926 11354928 SS.SHR-(D9Mco110-D9Mco114)/Bj This is a congenic substrain developed by crossing SS.SHR-(D9Rat7-D9Rat84)/Mco to SS/Jr and the F1 were intercrossed to produce an F2 population,which was genotyped using microsatellite markers. The selected recombinant rats were crossed to SS/Jr again to duplicate the recombinant region. University of Toledo College of Medicine and Life Sciences congenic Unknown 9 86987972 87252238 1 - by flanking markers 9 94881322 95143906 1 - by flanking markers 9 95162214 95162463 1 - by flanking markers 9 88698037 88698287 1 - by flanking markers RRID:RGD_11354928 11354930 SS.SHR-(D9Mco115-D9Mco124)/Bj This is a congenic substrain developed by crossing SS.SHR-(D9Rat7-D9Rat84)/Mco to SS/Jr and the F1 were intercrossed to produce an F2 population,which was genotyped using microsatellite markers. The selected recombinant rats were crossed to SS/Jr again to duplicate the recombinant region. University of Toledo College of Medicine and Life Sciences congenic Unknown 9 89708990 89709209 1 - by flanking markers 9 95727999 97361568 1 - by flanking markers 9 96024146 97679852 1 - by flanking markers 9 89541728 91114199 1 - by flanking markers RRID:RGD_11354930 11528524 LE-Tg(Slc17a6-icre)3Ottc The BAC-based transgene contains Cre recombinase is expressed from rat Slc17a6 promoter. Optogenetics and Transgenic Technology Core transgenic Extinct (as of 2019-02-01) RRID:RGD_11528524 11528588 SHR.LEW-(D4Rat76-D4Mgh11)/Anra This congenic strain contains a LEW chromosome 4 segment containing a QTL affecting anxiety-related response transferred to the SHR background. Laboratorio de Genetica do Comportamento, Departamento de Biologia Celular, Embriologia e Genetica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brazil congenic Unknown 4 84886545 171204531 1 - by flanking markers 4 150964994 230565226 1 - by flanking markers 4 86312589 168047091 1 - by flanking markers 4 85253748 167139601 1 - by flanking markers RRID:RGD_11528588 11530008 CDS.CDR-(D4Rat9-D4Rat153)/Ygl This CDS congenic containing genomic elements from CDR was created by crossing the consomic strain CDS-Chr 4CDR/Ygl(RGD:4889499) with CDS. The congenic carries QTL affecting diabeties initation. Laboratory for Molecular Medicine and Israeli Rat Genome Center Barzilai University Med Ctr Campus 2 Hahistadrut St Ashkelon 78278, Israel congenic Unknown 4 23537363 23537525 1 - by flanking markers 4 23916923 23917084 1 - by flanking markers 4 23991721 23991882 1 - by flanking markers 4 26907285 26907447 1 - by flanking markers RRID:RGD_11530008 11530011 CDS.SBN-(D13Rat85-D13Mit4)/Ygl This CDS congenic containing the genomic element from SBN/Ygl was created by crossing the SBN/Ygl with CDS. The congenic carries QTL affecting diabeties development. Laboratory for Molecular Medicine and Israeli Rat Genome Center Barzilai University Med Ctr Campus 2 Hahistadrut St Ashkelon 78278, Israel congenic Unknown 13 72141292 90551272 1 - by flanking markers 13 79488981 97381801 1 - by flanking markers 13 74568378 92916783 1 - by flanking markers 13 69060519 86800898 1 - by flanking markers RRID:RGD_11530011 11530028 iNP-Npyem6Sage/Iusm These ZFN mutant rats were produced by injecting zinc finger nuclease targeting rat Npy into iNP/Iusm embryos. A 26-bp deletion, including 6 bp in intron 1 and 20 bp in exon 2 in rat Npy was created in the mutant founders. These mutant founders were backcrossed with iNP/Iusm to produce heterozygous offspring, which were then intercrossed to produce homozygous and heterozygous offspring. Department of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN 46202, USA mutant Unknown Npyem6Sage 11530022 4 78038013 78045187 1 - by flanking markers 4 144233753 144240956 1 - by flanking markers 4 79557856 79565059 1 - by flanking markers 4 78881294 78888495 1 - by flanking markers RRID:RGD_11530028 11531089 SD-F8em1Sage+/-/Novo The heterozygous ZFN mutant rats were produced by backcrossing mutant founders (SD/Novo-F8em1Sage) with Sprague Dawley. Genotyping of the offspring was carried out by PCR amplification of the deletion fragment which caused a premature translation stop. Novo Nordisk, Maaloev, Denmark mutant Unknown F8em1Sage 11531096 18 121134 162008 1 - by flanking markers 18 413447 444491 1 - by flanking markers 18 367862 399242 1 - by flanking markers 18 140848 172330 1 - by flanking markers RRID:RGD_11531089 11531091 SD-F8em1Sage-/-/Novo The homozygous F8 mutant rats were produced by intercrossing the heterozygous ZFN mutants (SD-F8em1Sage+/-/Novo) to produce homozygous and heterozygous offspring. Genotype of the homozygous offspring was confirmed by PCR amplification of the deletion fragment which caused a premature translation stop. Novo Nordisk, Maaloev, Denmark mutant Unknown F8em1Sage 11531096 18 121134 162008 1 - by flanking markers 18 413447 444491 1 - by flanking markers 18 367862 399242 1 - by flanking markers 18 140848 172330 1 - by flanking markers RRID:RGD_11531091 11531094 SD-F8em1Sage/Novo These ZFN mutant rats were produced by injecting zinc finger nuclease targeting rat F8 into Sprague Dawley embryos. A premature translation stop in rat F8 was created in the mutant founders carrying a 13-bp deletion in exon 16. These mutant founders were backcrossed with Sprague Dawley to produce heterozygous offspring, which were then intercrossed to produce homozygous and heterozygous offspring. Novo Nordisk, Maaloev, Denmark mutant Unknown F8em1Sage 11531096 18 121134 162008 1 - by flanking markers 18 413447 444491 1 - by flanking markers 18 367862 399242 1 - by flanking markers 18 140848 172330 1 - by flanking markers RRID:RGD_11531094 11531104 iNP-Npyem6Sage+/-/Iusm The heterozygous ZFN mutant rats were produced by backcrossing mutant founders with iNP/Iusm. Genotyping of the offspring was carried out by PCR amplification of a 26-bp deleted fragment, including 6 bp in intron 1 and 20 bp in exon 2. Department of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN 46202, USA mutant Unknown Npyem6Sage 11530022 4 78038013 78045187 1 - by flanking markers 4 144233753 144240956 1 - by flanking markers 4 79557856 79565059 1 - by flanking markers 4 78881294 78888495 1 - by flanking markers RRID:RGD_11531104 11531106 iNP-Npyem6Sage-/-/Iusm The homozygous Npy mutant rats were produced by intercrossing the heterozygous ZFN mutants (iNP-Npyem6Sage+/- /Iusm) to produce homozygous and heterozygous offspring. Genotype of the homozygous offspring was confirmed by PCR amplification of a 26-bp deleted fragment, including 6 bp in intron 1 and 20 bp in exon 2. Department of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN 46202, USA mutant Unknown Npyem6Sage 11530022 4 78038013 78045187 1 - by flanking markers 4 144233753 144240956 1 - by flanking markers 4 79557856 79565059 1 - by flanking markers 4 78881294 78888495 1 - by flanking markers RRID:RGD_11531106 11532753 F344.ZUC-(Leprfa),OLETF-(D5Rat166-D5Rat90)/Tj The F344.ZUC,OLETF double congenic was produced by crossing F344.ZUC-Leprfa with F344.OLETF-( D5Rat166-D5Rat90) and then selecting Leprfa -Niddm24 (fa/fa-Nidd6/of) homozygotes National BioResource Project for the Rat in Japan congenic Unknown Diabetes Obesity RRID:RGD_11532753 11535000 PKD/Mhm PKD The colony of inbred PKD/Mhm rats was established in the laboratory in Mannheim after 18 additional generations of inbreeding of the Han:SPRD (cy/+).The mutation was a C to T transition that replaces an arginine by a tryptophan at amino acid 823 in the protein sequence. Medical Research Centre, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany inbred Unknown (as of 2016-11-29) Anks6PKD 11534996 RRID:RGD_11535000 11535031 SD-Tg(hCMV-Anks6PKD)Mhm This transgenic strain was derived by pronuclear microinjection of fertilized Sprague Dawley oocytes with a 2.8-kb mutated Anks6PKD cloned between a human cytomegalovirus promoter upstream and an intron as well as a polyadenylation signal of SV40 downstream. Medical Research Centre, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany transgenic Unknown (as of 2016-11-29) Anks6PKD 11534996 RRID:RGD_11535031 11535955 Crlj:CD(SD) A colony of outbred CD(SD) (RGD: 734476) maintained in the Charles River Laboratories Japan. Charles River Laboratories outbred Unknown RRID:RGD_11535955 11553848 WKY-Trpv4em5Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Trpv4 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp deletion in Exon 4 of the Trpv4 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Trpv4em5Mcwi 11553847 12 43226933 43265889 1 - by flanking markers 12 49492064 49529956 1 - by flanking markers 12 47698915 47737902 1 - by flanking markers 12 41938533 41977517 1 - by flanking markers RRID:RGD_11553848 11553850 WKY-Trpv4em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Trpv4 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 4-bp deletion in Exon 4 of the Trpv4 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Trpv4em4Mcwi 11553851 12 43226933 43265889 1 - by flanking markers 12 49492064 49529956 1 - by flanking markers 12 47698915 47737902 1 - by flanking markers 12 41938533 41977517 1 - by flanking markers RRID:RGD_11553850 11553852 SS-Vnn1em2Mcwi CRISPR/Cas9 system and ssODN was used to introduce a N131S mutation in the Vnn1 gene of SS/HsdMcwiCrl rat embryos MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Vnn1em2Mcwi 11553853 1 22087290 22097592 1 - by flanking markers 1 24089365 24099667 1 - by flanking markers 1 22614832 22625134 1 - by flanking markers 1 21537084 21547395 1 - by flanking markers RRID:RGD_11553852 11553855 SS-Vnn1em1Mcwi CRISPR/Cas9 system was used to introduce a 7-bp deletion mutation in the Vnn1 gene of SS/HsdMcwiCrl rat embryos MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Vnn1em1Mcwi 11553856 1 22087290 22097592 1 - by flanking markers 1 24089365 24099667 1 - by flanking markers 1 22614832 22625134 1 - by flanking markers 1 21537084 21547395 1 - by flanking markers RRID:RGD_11553855 11553858 SS-Rbm20em5Mcwi ZFN system was used to introduce a mutation in the Rbm20 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 121-bp deletion in Exon 2 of the Rbm20 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Rbm20em5Mcwi 11553857 1 259905545 260144190 1 - by flanking markers 1 281783646 282003053 1 - by flanking markers 1 274391932 274589816 1 - by flanking markers 1 252683760 252907465 1 - by flanking markers RRID:RGD_11553858 11553860 DA-Scn5aem2Mcwi ZFN system was used to introduce a mutation in the Scn5a gene of DA/MolTac rat embryos. The resulting mutation is a 110-bp deletion in Exon 4 of the Scn5a gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Scn5aem2Mcwi 11553859 8 124446479 124545301 1 - by flanking markers 8 127375781 127471879 1 - by flanking markers 8 128169191 128266681 1 - by flanking markers 8 119220905 119318816 1 - by flanking markers RRID:RGD_11553860 11553862 SS-Shc1em1Mcwi ZFN system was used to introduce a mutation in the Shc1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp deletion in Exon 2 of the Shc1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Shc1em1Mcwi 11553854 2 181616581 181628144 1 - by flanking markers 2 208159786 208171348 1 - by flanking markers 2 188745503 188757066 1 - by flanking markers 2 174837937 174849538 1 - by flanking markers RRID:RGD_11553862 11553873 LE-Fmr1em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Fmr1 gene of Crl:LE rat embryos. The resulting mutation is a 2-bp insertion in exon 8 of the Fmr1 gene. Generated with support from the Simons Foundation Autism Research Initiative (SFARI ); MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals; Cryopreserved Sperm (as of 2021-11-03) Autism, ADHD, Developmental delay, Intellectual disability, Epilepsy (from SFARI GENE) Fmr1em2Mcwi 11553872 X 154756031 154793782 1 - by flanking markers 1 150408220 150445658 1 - by flanking markers X 154684924 154722369 1 - by flanking markers X 147240239 147278057 1 - by flanking markers RRID:RGD_11553873 11553875 LE-Fmr1em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Fmr1 gene of Crl:LE rat embryos. The resulting mutation is a 2-bp deletion in exon 8 of the Fmr1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Fmr1em4Mcwi 11553874 X 154756031 154793782 1 - by flanking markers 1 150408220 150445658 1 - by flanking markers X 154684924 154722369 1 - by flanking markers X 147240239 147278057 1 - by flanking markers RRID:RGD_11553875 11553877 SS-P2rx1em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the P2rx1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 24-bp deletion in Exon 1 of the P2rx1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Extinct (as of 2017-07-18) P2rx1em1Mcwi 11553876 10 59889933 59904985 1 - by flanking markers 10 59305737 59320797 1 - by flanking markers 10 59566268 59581328 1 - by flanking markers 10 57618586 57633648 1 - by flanking markers RRID:RGD_11553877 11553881 SS-Rbm20em10Mcwi ZFN system was used to introduce a mutation in the Rbm20 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp deletion in Exon 2 of the Rbm20 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Rbm20em10Mcwi 11553880 1 259905545 260144190 1 - by flanking markers 1 281783646 282003053 1 - by flanking markers 1 274391932 274589816 1 - by flanking markers 1 252683760 252907465 1 - by flanking markers RRID:RGD_11553881 11553883 SS-Rbm20em8Mcwi ZFN system was used to introduce a mutation in the Rbm20 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 58-bp deletion in Exon 2 of the Rbm20 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Rbm20em8Mcwi 11553882 1 259905545 260144190 1 - by flanking markers 1 281783646 282003053 1 - by flanking markers 1 274391932 274589816 1 - by flanking markers 1 252683760 252907465 1 - by flanking markers RRID:RGD_11553883 11553886 SD-Tp53em3Mcwi ZFN system was used to introduce a mutation in the Trp53 gene of Crl:SD rat embryos.The resulting mutation is a 84-bp deletion in Exon 3 of the Tp53 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Tp53em3Mcwi 11553885 10 56399721 56411150 1 - by flanking markers 10 55932658 55944087 1 - by flanking markers 10 56186299 56198449 1 - by flanking markers 10 54300070 54311525 1 - by flanking markers RRID:RGD_11553886 11553889 SS-Trpc3em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Trpc3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 25-bp deletion in Exon 2 of the Trpc3 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm; Cryorecovery (as of 2018-10-10) Trpc3em2Mcwi 11553887 2 123117180 123184016 1 - by flanking markers 2 142945309 143022844 1 - by flanking markers 2 123329954 123467574 1 - by flanking markers 2 119481313 119619333 1 - by flanking markers RRID:RGD_11553889 11553892 SS-Trpc3em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Trpc3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp insertion in Exon 2 of the Trpc3 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-10) Trpc3em1Mcwi 11553891 2 123117180 123184016 1 - by flanking markers 2 142945309 143022844 1 - by flanking markers 2 123329954 123467574 1 - by flanking markers 2 119481313 119619333 1 - by flanking markers RRID:RGD_11553892 11553894 SS-Tpcn2em1Mcwi ZFN system was used to introduce a mutation in the Tpcn2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 9-bp deletion in Exon 4 of theTpcn2 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Tpcn2em1Mcwi 11553893 1 205702971 205732664 1 - by flanking markers 1 225286480 225316685 1 - by flanking markers 1 218419182 218448902 1 - by flanking markers 1 200416538 200446252 1 - by flanking markers RRID:RGD_11553894 11553896 SHRSP-Spp1em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Spp1 gene of SHRSP/A3NCrl rat embryos. The resulting mutation is a 5-bp deletion in Exon 3 of the Spp1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Spp1em1Mcwi 11553895 14 6653086 6658937 1 - by flanking markers 14 6673686 6679965 1 - by flanking markers 14 5308885 5315120 1 - by flanking markers RRID:RGD_11553896 11553899 WKY-Trpv2em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Trpv2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 17-bp deletion in Exon 4 of the Trpv2 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Trpv2em1Mcwi 11553898 10 48764894 48786150 1 - by flanking markers 10 48686500 48707996 1 - by flanking markers 10 48903540 48925036 1 - by flanking markers 10 47265524 47294263 1 - by flanking markers RRID:RGD_11553899 11553902 SS-Trpc6em3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Trpc6 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 18-bp deletion in Exon 2 of the Trpc6 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Trpc6em3Mcwi 11553901 8 5472515 5577537 1 - by flanking markers 8 6799564 6904623 1 - by flanking markers 8 6811543 6917534 1 - by flanking markers 8 5759387 5864000 1 - by flanking markers RRID:RGD_11553902 11553904 SS-Shc1em3Mcwi ZFN system was used to introduce a mutation in the Shc1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 27-bp deletion in Exon 1 of the Shc1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Shc1em3Mcwi 11553903 2 181616581 181628144 1 - by flanking markers 2 208159786 208171348 1 - by flanking markers 2 188745503 188757066 1 - by flanking markers 2 174837937 174849538 1 - by flanking markers RRID:RGD_11553904 11553908 SS-Trpc6em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Trpc6 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 3-bp substitutions to generate P112Q in Exon 2 of the Trpc6 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Trpc6em4Mcwi 11553907 8 5472515 5577537 1 - by flanking markers 8 6799564 6904623 1 - by flanking markers 8 6811543 6917534 1 - by flanking markers 8 5759387 5864000 1 - by flanking markers RRID:RGD_11553908 11553912 SS-Trpc6em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Trpc6 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 2-bp insertion in Exon 2 of the Trpc6 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Trpc6em1Mcwi 11553911 8 5472515 5577537 1 - by flanking markers 8 6799564 6904623 1 - by flanking markers 8 6811543 6917534 1 - by flanking markers 8 5759387 5864000 1 - by flanking markers RRID:RGD_11553912 11553914 SS-Shc1em4Mcwi ZFN system was used to introduce a mutation in the Shc1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 13-bp deletion in Exon 2 of theShc1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2017-01-26) Shc1em4Mcwi 11553913 2 181616581 181628144 1 - by flanking markers 2 208159786 208171348 1 - by flanking markers 2 188745503 188757066 1 - by flanking markers 2 174837937 174849538 1 - by flanking markers RRID:RGD_11553914 11553916 SS-Shc1em5Mcwi ZFN system was used to introduce a T>G transversion mutation in the Shc1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a substitution to generate S36A in Exon 2 of theShc1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals (as of 2017-01-25) Shc1em5Mcwi 11553915 2 181616581 181628144 1 - by flanking markers 2 208159786 208171348 1 - by flanking markers 2 188745503 188757066 1 - by flanking markers 2 174837937 174849538 1 - by flanking markers RRID:RGD_11553916 11554327 BDIX.BDIV-D10Mit3-D10Mgh16/Zte The BDIX.BDIV-D10Mit3-D10Mgh16/Zte congenic strain was produced by crossing BDIX (tumor-susceptible) and BDIV (tumor resistant) and then selecting for strains carrying homozygous segments of the BDIV chromosome on a BDIX background. Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany congenic Live Animals (as of 2016-10-26) RRID:RGD_11554327 11554329 BDIX.BDIV-D10Got1-D10Rat45/Zte The BDIX.BDIV-D10Got1-D10Rat45/Zte congenic strain was produced by crossing BDIX (tumor-susceptible) and BDIV (tumor resistant) and then selecting for strains carrying homozygous segments of the BDIV chromosome on a BDIX background. Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany congenic Live Animals (as of 2016-10-26) 10 4697541 20233281 1 - by flanking markers 10 3662335 20046466 1 - by flanking markers 10 4835638 20170031 1 - by flanking markers 10 4765527 19816042 1 - by flanking markers RRID:RGD_11554329 11556280 ACI.Cg-Du/Kyo Downunder (Du) mutation is introduced into ACI/Kyo strain. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2016-11-10) Development RRID:RGD_11556280 11556282 WKY-Tg(UBC-sb10)3Wmukf This strtain has transgene that express SleepingBeauty transposase under human Ubiquitin-C promoter. (insertion site of trans gene: unknown) National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2016-11-10) RRID:RGD_11556282 11561897 Crl:WI-Lrapem1Geh The CRISPR/Cas9 genome editing system was used to generate this knockout mutant rat strain. It created a 618-bp deletion in rat Lrap gene. The recipient zygotes were the Wistar rats from Charles River. University of Colorado mutant Unknown behavior, addiction Lrapem1Geh 11561896 12 40910874 40918231 1 - by flanking markers 12 39016258 39017876 1 - by flanking markers 12 33562482 33574339 1 - by flanking markers RRID:RGD_11561897 11561902 WKY-Tg(UBC-pb)5Wmukf This strtain has transgene that expresses piggyBac transposase under human Ubiquitin-C promoter. (insertion site of trans gene: unknown) National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2016-11-10) RRID:RGD_11561902 11561905 WKY-Tg(Gabrb1Tn(pb-Bhr2)1Wmukf) Transposed "Bhr2" was inserted into intron 4 of Gabrb1 gene by piggyBac (pb) transposon system. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2016-11-10) Gabrb1|Gabrb1Tn(pb-Bhr2)1Wmukf 2649|11561925 14 38530259 39005615 1 - by flanking markers 14 38453142 38924073 1 - by flanking markers 14 38631192 39112598 1 - by flanking markers 14 36068725 36548946 1 - by flanking markers RRID:RGD_11561905 11561909 WKY-Tg(Samt4Tn(pb-Bhr7)1Wmukf) Transposed "Bhr7" was inserted into the first Met-coding exon region of rat Samt4 gene by piggyBac (pb) transposon system. National BioResource Project for the Rat in Japan transgenic Extinct (as of 2016-11-10) Samt4Tn(pb-Bhr7)1Wmukf 11561928 RRID:RGD_11561909 11561966 LE.AR-Ednrbsl/Hkv Aganglionosis rat This strain was derived from LE.AR-Ednrbsl/Okkm (NBRP-Rat # 0557 LE.AR-EdnrbSl/Okkm) provided by Dr. Dr.Ozaki to Dr. Agui at Hokkaido University. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan, National BioResource Project for the Rat in Japan congenic Unknown (as of 2016-11-15) Internal Medicine RRID:RGD_11561966 11561970 WKY-Tg(Zbtb20Tn(pb-Bhr7)1Wmukf) Transposed "Bhr7" was inserted into the Intron 3 of Zbtb20 gene by piggyBac (pb) transposon system. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2016-11-15) Zbtb20Tn(pb-Bhr7)1Wmukf 11561972 RRID:RGD_11561970 11561976 WKY-Tg(Plcb1Tn(pb-Bhr2)1Wmukf) Transposed "Bhr2" was inserted into into Plcb1 gene by piggyBac (pb) transposon system. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2016-11-15) Plcb1Tn(pb-Bhr2)1Wmukf 11561974 RRID:RGD_11561976 11561979 LE-Tg((ROSA26)Sor-CAG-tdTomato)9Jfhy Background strain: Long-Evans (Institute for Animal Reproduction); pRSET-B tdTomato is provided by Dr. Roger Tsien(UCSD); Transgene: CAG promoter (CMV virus, chicken), tdTomato(Discosoma sp.); BAC clone: mouse ROSA26 BAC (RP23-244D9) National BioResource Project for the Rat in Japan transgenic Unknown (as of 2016-11-16) RRID:RGD_11561979 11564343 LE-Tg((ROSA26)Sor-CAG-tdTomato)14Jfhy Background strain: Long-Evans (Institute for Animal Reproduction); pRSET-B tdTomato is provided by Dr. Roger Tsien (UCSD); Transgene: CAG promoter (CMV virus, chicken), tdTomato (Discosoma sp.); BAC clone: mouse ROSA26 BAC (RP23-244D9) National BioResource Project for the Rat in Japan transgenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2016-11-16) RRID:RGD_11564343 11564346 F344-Aspaem31Kyo The TALEN genome editing system was used to generate this mutant rat strain. The TALEN system caused a 14-bp deletion in the exon4 of Aspa gene, as a result created a premature stop codon in the gene. Decreased expression levels of Aspa gene and ASPA protein was observed. Histopatologically, this strain shows vacuole formation in the brain and spinal cord. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2016-11-16) Aspaem31Kyo 11564344 10 60178509 60199207 1 - by flanking markers 10 59578788 59627450 1 - by flanking markers 10 59839693 59888244 1 - by flanking markers 10 57891704 57945267 1 - by flanking markers RRID:RGD_11564346 11564349 F344-Aspaem34Kyo The TALEN genome editing system was used to generate this mutant rat strain. The TALEN system caused a 16-bp deletion in the exon4 of Aspa gene, as a result created a premature stop codon in the gene. Decreased expression levels of Aspa gene and ASPA protein was observed. Histopatologically, this strain shows vacuole formation in the brain and spinal cord. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2016-11-16) Aspaem34Kyo 11564348 10 60178509 60199207 1 - by flanking markers 10 59578788 59627450 1 - by flanking markers 10 59839693 59888244 1 - by flanking markers 10 57891704 57945267 1 - by flanking markers RRID:RGD_11564349 11564350 SCR/Sscr Shumiya Cataract Rat Genetic Cataract rat SCR（Shumiya Cataract Rat）was segrigated from a SHR-fa strain colony that developed nuclear cataract at adult stage. This strain is a double mutant caused by recessive gene (ctr1) and dominant lethal gene (Ctr2l) and established by Dr. Shumiya at Tokyo Metropolitan Institute of Gerontology. In 2003, this strain was introduced to Kyoritsu College of Pharmacy (keio University Faculty of Pharmacy). ctr1 is lanosterol synthase (Lss) and Ctr2 is farnesyl diphosphate farnesyl transferase 1 (Fdft1). congenic Cryopreserved Embryo (as of 2016-11-16) Fdft1|Lss 61834|620955 RRID:RGD_11564350 11565091 F344-Ccdc85cem1Kyo TALEN targeting the exon1 of rat Ccdc85c gene was designed and mRNA coding these TALEN was microinjected into F344/Stm embyo. Rats developed hydrocephalus and Subcortical heterotopia. Homozygous rats die within 1 month of hydrocephalus. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2016-11-18) Ccdc85cem1Kyo 11565090 6 132572485 132641431 1 - by flanking markers 6 141284186 141353658 1 - by flanking markers 6 132113806 132183434 1 - by flanking markers 6 127113440 127184328 1 - by flanking markers RRID:RGD_11565091 11565094 F344.LEC-(D4Nirs8-D4Nirs2)/Nrs This strain was established by crossing F344.LEC-xhs1/1Nrs (NBR-rat #0293)(RGD:2304293) with F344/NSlc (RGD:1302627). The radiation sensitivity level of this strain is similar to F344.LEC-xhs1/1Nrs. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2016-11-18) RRID:RGD_11565094 11565097 F344.LEC-(D4Rat54-D4Got87)/Nrs This strain was established by crossing F344.LEC-xhs1/1Nrs (NBRrat NO: 0293)(RGD:2304293) with F344/NSlc (RGD:1302627). The radiation sensitivity level of this strain is different from F344.LEC-xhs1/1Nrs. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2016-11-18) RRID:RGD_11565097 11565100 NMC/Nrs This strain was found in a colony of F344.LEC-xhs1/1Nrs (NBRP Rat No: 0293). As to radiosensitivity gene, D4Nirs8-D4Rat45 region is LEC type. Affected females with dominant gene on Chr10 develop mammary gland cancer after pregnancy (histological type is undetermined). In many cases, this neoplastis lesion resolve spontaneously after delivery. No homozygous female is obtained at this time. Affected male rats don't show any phenotype. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2016-11-18) RRID:RGD_11565100 11565116 LE-Tg(Chat-tdTomato)3Yyan Chat-tdToamto-polyA-FRT sequence was inserted into fertilized egg of Long Evans strain (Japan SLC). vector: BAC clone (RP23-246B12) from a C57BL/6J mouse genomic BAC library (BACPAC Resource Center, Oakland, CA, USA) National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2016-11-21) RRID:RGD_11565116 11565122 SHR.Cg-Leprcp-Tg(APOB)110/Dmcr A BAC clone (CTD-2257F14) containing whole human APOB gene was maicroinjected into fertilized eggs of Wistar rats (Takeda Pharmaceutical Company). Then this Tg rats were backcrossed 9 times with SHR/NDmcr-cp rats (NBRP No.0446, SHR.Cg-Leprcp/NDmcr)(RGD: 2306033) National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo (as of 2016-11-21) Leprcp 11570565 RRID:RGD_11565122 11565125 SHRSP.SHR-(D18Rat87-D18Got66)/Izm A congenic strain made by introducing a segments of chromosome 18 from SHR/Izm into SHRSP/Izm. National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm (as of 2016-11-21) 18 66217583 80805774 1 - by flanking markers 18 64552961 80162163 1 - by flanking markers 18 65366908 81115720 1 - by flanking markers 18 63140870 77629361 1 - by flanking markers RRID:RGD_11565125 11565128 SHRSP.SHR-(D18Rat73-D18Rat52)/Izm A congenic strain made by introducing a segments of chromosome 18 from SHR/Izm into SHRSP/Izm. National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm (as of 2016-11-21) 18 52290789 61290878 1 - by flanking markers 18 50804228 59735418 1 - by flanking markers 18 51609032 60532087 1 - by flanking markers 18 49999958 58536311 1 - by flanking markers RRID:RGD_11565128 11565130 SHRSP.SHR-(D1Rat23-D1Rat213)/Izm A congenic strain made by introducing a segments of chromosome 1 from SHR/Izm into SHRSP/Izm National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm (as of 2016-11-21) Diabetes Obesity 1 78685103 81548909 1 - by flanking markers 1 81497710 84537228 1 - by flanking markers 1 80231217 83282814 1 - by flanking markers 1 78970983 81777720 1 - by flanking markers RRID:RGD_11565130 11565132 SHRSP.SHR-(D1Rat95-D1Got87)/Izm A congenic strain made by introducing a segments of chromosome 1 from SHR/Izm into SHRSP/Izm National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm (as of 2016-11-21) Diabetes Obesity 1 66832211 85828306 1 - by flanking markers 1 73096563 92291485 1 - by flanking markers 1 71706292 91156803 1 - by flanking markers 1 68123229 86030749 1 - by flanking markers RRID:RGD_11565132 11565135 WKY.SHRSP-(D1Rat25-St8sia2)/Izm A congenic strain established by introducing segments of chromosome 1 from SHRSP/Izm into WKY/Izm. National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Unknown (as of 2016-11-21) St8sia2 621843 1 72231246 129191810 1 - by flanking markers 1 67633807 136423629 1 - by flanking markers 1 66845268 135406699 1 - by flanking markers 1 72703913 127838017 1 - by flanking markers RRID:RGD_11565135 11565826 F344-Ttnem1Sage These ZFN mutant rats were produced by injecting zinc finger nuclease targeting rat Ttn into F344 embryos. The zinc-finger nuclease mediated genome editing system created a 12-bp deletion and a 2-bp insertion (TA) at 228,608-228,619 (Rnor_5.0) to introduce a stop codon in exon 303, corresponding to exon 327 in the human sequence. Duke-National University of Singapore, Singapore mutant Unknown (as of 2016-11-28) Ttnem1Sage 11565825 3 59404023 59665308 1 - by flanking markers 3 70138896 70408647 1 - by flanking markers 3 63565160 63837815 1 - by flanking markers 3 61652432 61924912 1 - by flanking markers RRID:RGD_11565826 11565829 F344-Ttnem2Sage These ZFN mutant rats were produced by injecting zinc finger nuclease targeting rat Ttn into F344 embryos. The zinc-finger nuclease mediated genome editing system created a deletion of exons 2-6 (5,286-bp deletion, coordinates 2,323-7,608) to introduce a frameshift (Rnor_5.0). Duke-National University of Singapore, Singapore mutant Unknown (as of 2016-11-28) Ttnem2Sage 11565827 3 59404023 59665308 1 - by flanking markers 3 70138896 70408647 1 - by flanking markers 3 63565160 63837815 1 - by flanking markers 3 61652432 61924912 1 - by flanking markers RRID:RGD_11565829 11567272 SD-Mecp2em1Sage The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Mecp2 into Sprague Dawley embryos. This mutant rat has a knockout of the methyl CpG binding protein 2 (Mecp2). Horizon Discovery mutant Live Animals (as of 2016-12-13) Autism, Rett syndrome, Cognition Mecp2em1Sage 11568035 X 159980599 160035260 1 - by flanking markers 1 152390961 152461647 1 - by flanking markers X 156650389 156713813 1 - by flanking markers X 151781177 151844687 1 - by flanking markers RRID:RGD_11567272 11568040 SD-Fmr1em1Sage The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Fmr1 into Sprague Dawley embryos. This mutant rat has a knockout of Fmr1. Horizon Discovery mutant Live Animals (as of 2017-05-09) Autism, Fragile X syndrome Fmr1em1Sage 11568041 X 154756031 154793782 1 - by flanking markers 1 150408220 150445658 1 - by flanking markers X 154684924 154722369 1 - by flanking markers X 147240239 147278057 1 - by flanking markers RRID:RGD_11568040 11568058 SD-Nrxn1em1Sage The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Nrxn1 into Sprague Dawley embryos. This mutant rat has a 16-bp deletion in exon1 resulting in knockout of Nrxn1. Horizon Discovery mutant Live Animals (as of 2018-03-22) Autism, Schizophrenia Nrxn1em1 11568059 6 14050929 15354069 1 - by flanking markers 6 23843153 25145167 1 - by flanking markers 6 13886757 15191660 1 - by flanking markers 6 3177788 4323848 1 - by flanking markers RRID:RGD_11568058 11568062 SD-Ptenem1Sage The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Pten into Sprague Dawley embryos. This mutant rat has a 7-bp deletion in exon7 resulting in knockout of Pten. Horizon Discovery mutant Live Animals (as of 2016-12-13) Autism, cancer Ptenem1Sage 11568063 1 236771027 236837261 1 - by flanking markers 1 258651829 258717009 1 - by flanking markers 1 251421814 251487634 1 - by flanking markers 1 230631303 230696754 1 - by flanking markers RRID:RGD_11568062 11568067 SD-Grm5em1Sage The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Grm5 into Sprague Dawley embryos. The resulting mutation was a knockout of Grm5 demonstrated by western blot. Horizon Discovery mutant Live Animals; Cryopreserved Embryo (as of 2016-12-13) Autism, Fragile X syndrome, Cognition, Schizophrenia, Anxiety, Pain Grm5em1Sage 11568068 RRID:RGD_11568067 11568071 SD-Metem1Sage The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Met into Sprague Dawley embryos. The resulting mutation was a a-17 base pair deletion in exon 8 of Met. Horizon Discovery mutant Cryopreserved Embryo (as of 2016-12-07) Autism Spectrum Disorders, Synaptic Plasticity, Autoimmune disorders Metem1Sage 11568072 4 43134183 43211355 1 - by flanking markers 4 45354290 45461638 1 - by flanking markers 4 44747467 44854628 1 - by flanking markers 4 45790456 45898139 1 - by flanking markers RRID:RGD_11568071 11568646 SD-Cntnap2em1Sage The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Met into Sprague Dawley embryos. The resulting mutation was a 5-bp deletion in exon 6 of Cntnap2. Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot. Horizon Discovery mutant Live Animals (as of 2017-05-05) Autism Spectrum Disorders, Synaptic Plasticity, Language disorders Cntnap2em1Sage 11568647 4 74277978 75440178 1 - by flanking markers 4 140006078 141697964 1 - by flanking markers 4 74700539 77025463 1 - by flanking markers 4 74109455 76366434 1 - by flanking markers RRID:RGD_11568646 11568700 SD-Nlgn3em1Sage The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Nlgn3 into Sprague Dawley embryos. Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot. Horizon Discovery mutant Live Animals; Cryopreserved Embryo (as of 2016-12-13) Autism, Asperger's syndrome, Synaptic plasticity Nlgn3em1Sage 11568701 X 89376193 89398665 1 - by flanking markers X 72051846 72075119 1 - by flanking markers X 71199390 71227460 1 - by flanking markers X 66427926 66457378 1 - by flanking markers RRID:RGD_11568700 11568703 SD-Cacna1cem1Sage The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Nlgn3 into Sprague Dawley embryos. This model contains 4-bp deletion at 460,649 to 460,652 bp in genomic sequence resulting in an early stop codon in exon 6. Horizon Discovery mutant Cryopreserved Embryo (as of 2016-12-13) Autism, Timothy syndrome, Long QT syndrome, Schizophrenia,Bipolar disorder Cacna1cem1Sage 11568704 4 154895691 155517389 1 - by flanking markers 4 216562477 217184927 1 - by flanking markers 4 150635808 151270790 1 - by flanking markers 4 151764138 152379454 1 - by flanking markers RRID:RGD_11568703 11667072 Sway/Rrrc This phenotype arose spontaneously during the third generation of selective breeding for decreased intravenous drug self-administration in Wistar rats (see RGD:6482259). After 10 weeks of age no drug administration is needed to see phenotype in which animals exhibits motor abnormalities with degenerative changes in cerebellar Purkinje cells. It appears to be transmitted in an autosomal recessive pattern. Animals have an abnormal swaying gait, which is readily identified as a slow (2 to 3 cycles per second) tremor. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26) RRID:RRRC_00538 11667077 SD-Esr2em2Soar Zinc finger nuclease targeting of exon 3 of the rat estrogen receptor-2 gene resulting in the deletion of exon 3. Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) reproduction, neu7roscience, environmental healthg, cardiovascular RRID:RRRC_00719 11667079 SD-Pgrem2Soar zinc finger nucleases were used to generate a 136 bp deletion within the first exon of the progesterone receptor, resulting in a frameshift, premature stop codon, and a null. Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) Reproduction, neuroscience, environmental health, cardiovascular RRID:RRRC_00720 11667081 BDIV-Myo5a/StcRrrc Point mutation in Myo5a (Chromosome 8, end of exon 4)identified in In Berlin-Druckrey (BDIV) shaker rats Rat Resource and Research Center inbred Cryopreserved Sperm (as of 2017-01-26) Myo5am1Stc 42721971 RRID:RRRC_00784 11667084 WCat Wistar Cataract Rat ENU induced total juvenile cataract in inbred Wistar. Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) RRID:RRRC_00704 11667088 SD-Esr1em1Soar zinc finger nucleases were used to generate a 482 bp deletion in Esr1 gene, resulting in a knock out. Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-01-26) A range of experimentation examining the actions of estrogen in reproduction, cancer, cardiovascular, and neurobiology. Esr1em1Soar 12910736 1 35523680 35759891 1 - by flanking markers 1 42534049 42935434 1 - by flanking markers 1 41192029 41594799 1 - by flanking markers 1 41106335 41499104 1 - by flanking markers RRID:RRRC_00701 11667094 W-Tg(CFH)Crl micro-injected with a ~6 kb transgenic cassette, which contained a CMV enhancer, chicken beta-actin promoter, the full-length cDNA encoding human complement factor H, and a rabbit beta-globin poly(A) sequence that had been isolated and purified from plasmid pCAGGS-human fH. Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2017-01-26) RRID:RRRC_00705 11667096 WIST-Tulane Tulane rat Male Wistar rats with inbred congenital unilateral right hydronephrosis were bred from the colony described in 1979 by Friedman et al. Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26) RRID:RRRC_00721 12437069 SS.BN-(D13Rat25-rs198199323)-Btg2em21Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Btg2 gene of SS.BN-(D13Rat25-rs198199323)/Mcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Btg2em21Mcwi 12798564 13 47026986 47030745 1 - by flanking markers 13 55966299 55970058 1 - by flanking markers 13 50913185 50916944 1 - by flanking markers 13 45531881 45535642 1 - by flanking markers RRID:RGD_12437069 12437071 SS.BN-(D13Rat25-rs198199323)-Btg2em24Mcwi CRISPR/Cas9 system was used to introduce a 2-bp insertion in the exon 1 in the Btg2 gene of SS.BN-(D13Rat25-rs198199323)/Mcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Btg2em24Mcwi 12798565 13 47026986 47030745 1 - by flanking markers 13 55966299 55970058 1 - by flanking markers 13 50913185 50916944 1 - by flanking markers 13 45531881 45535642 1 - by flanking markers RRID:RGD_12437071 12738212 SD-Tg(LRRK2*R1441C)268Rwm These rats were created using BAC constructs consisting of the entire 144kb human LRRK2 locus containing the R1441C mutation and fused to a YPet reporter tag. Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2017-08-22) Parkinson's Disease LRRK2 1353141 RRID:RRRC_00775 12738218 SD-GEPR-9 Genetically Epilepsy-Prone Rats (GEPR-9) have severe levels of seizure predisposition. This colony was bred to exhibit clonic convulsions (severe seizures with an ARS of 9) following a single wild running phase in response to sound. Seizures model human generalized tonic/clonic seizures. Rat Resource and Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-30) seizure RRID:RRRC_00304 12738365 SD-Rag2em2Mcwi This strain was produced by injecting TALENs targeting the sequence into Crl:SD rat embryos. The resulting mutation is a 10-bp frameshift deletion,Atgttgagat, in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Rag2em2Mcwi 12738366 3 86764810 86773438 1 - by flanking markers 3 97851318 97859615 1 - by flanking markers 3 91191837 91200134 1 - by flanking markers 3 87902373 87910227 1 - by flanking markers RRID:RGD_12738365 12738372 BDIX.BDIV-D6Mit1-D6Mgh2/Zte The BDIX.BDIV-D6Mit1-D6Mgh2/Zte congenic strain was produced by crossing BDIX (tumor-susceptible) and BDIV (tumor resistant) and then selecting for strains carrying homozygous segments of the BDIV chromosome on a BDIX background. Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany congenic Unknown RRID:RGD_12738372 12738388 BDIX.BDIV-D6Rat132-D6Mgh3/Zte The BDIX.BDIV-D6Rat132-D6Mgh3/Zte congenic strain was produced by crossing BDIX (tumor-susceptible) and BDIV (tumor resistant) and then selecting for strains carrying homozygous segments of the BDIV chromosome on a BDIX background. Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany congenic Unknown RRID:RGD_12738388 12738394 BDIX.BDIV-D6Mit8-D6Rat229/Zte The BDIX.BDIV-D6Mit8-D6Rat229/Zte congenic strain was produced by crossing BDIX (tumor-susceptible) and BDIV (tumor resistant) and then selecting for strains carrying homozygous segments of the BDIV chromosome on a BDIX background. Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany congenic Unknown RRID:RGD_12738394 12738452 ACI.F344-ApcPircUwm This strain develops twice the number of colonic tumors as the F344-ApcPircUwm rats (RGD:1641862). Stop codon mutation at amino acid 1137 of the Apc gene. Nucleotide chr18:26,785,272 (Baylor 3.4/rn4) A to T transversion. University of Wisconsin-Madison, Madison, Wisconsin, Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-02-06) ApcPirc 1554322 18 26732147 26790383 1 - by flanking markers 18 26725560 26820837 1 - by flanking markers 18 27011710 27106323 1 - by flanking markers 18 25828558 25925511 1 - by flanking markers RRID:RRRC_00718 12738455 DA.F344-(D10Got155-D10Nsi55) The Cia5a10 (D10Got155-D10Nsi55) interval was introgressed from F344 into DA/BklArb rats through 8 backcrosses into DA/BklArb rats followed by 7 additional backcrosses into DA/BklArbNsi rats. Heterozygous DA.F344(Cia5a10) rats were brother-sister mated, and the recombinant strain was maintained in the homozygous state thereafter. The Feinstein Institute for Medical Research. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-06) 10 105131088 105131258 1 - by flanking markers 10 104692565 104692735 1 - by flanking markers 10 103609431 103609601 1 - by flanking markers 10 100299840 100300011 1 - by flanking markers RRID:RRRC_00674 12738457 DA.F344-(D10Got152-D10Mcw1) DA/BklArb rats through 8 backcrosses into DA/BklArb rats followed by 7 additional backcrosses into DA/BklArbNsi rats. Heterozygous DA.F344(Cia5a5)(D10Got152-D10Mcw1) rats were brother-sister mated, and the recombinant strain was maintained in the homozygous state thereafter. The Feinstein Institute for Medical Research. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-06) 10 102307572 109926395 1 - by flanking markers 10 100889652 109306076 1 - by flanking markers 10 101211245 109712946 1 - by flanking markers 10 97730563 105813458 1 - by flanking markers RRID:RRRC_00675 12738460 DA.F344-(D7Rat15-D7Mit2) The Cia4d (D7Rat15 -D7Mit2) interval was introgressed from F344 into DA/BklArb rats through 7 backcrosses into DA/BklArb rats followed by 3 additional backcrosses into DA/BklArbNsi rats. Heterozygous DA.F344(Cia4d) rats were brother-sister mated, and the recombinant strain was maintained in the homozygous state thereafter. The Feinstein Institute for Medical Research. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-06) 7 107428268 123191874 1 - by flanking markers 7 110975825 125794357 1 - by flanking markers 7 111043360 126080454 1 - by flanking markers 7 101772987 116294546 1 - by flanking markers RRID:RRRC_00681 12738466 DA-Asipm1 Developed by Beth Bauer, University of Missouri. Spontaneous mutation of agouti gene with resultant black coat color from Sprague Dawley (SD) X Dark Agouti (DA). Albino mutation and hooded mutation have been bred out of this line so that only the agouti mutation remains. Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-02-06) This strain can be used to generate pigmented embryos for use with albino ES cell lines. Asipm1 12738467 3 145445175 145536831 1 - by flanking markers 3 156860395 156949277 1 - by flanking markers 3 150492010 150579870 1 - by flanking markers 3 143473584 143561170 1 - by flanking markers RRID:RRRC_00542 12743611 SS-Renem1Mcwi+/- SS-Renem1Mcwi+/Renem1Mcwi- ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2018-09-05) Renem1Mcwi 4139863 13 46262936 46275213 1 - by flanking markers 13 55555583 55566812 1 - by flanking markers 13 50502724 50513953 1 - by flanking markers 13 44796260 44807491 1 - by flanking markers RRID:RGD_12743611 12743623 BN.F344-ApcPirc The phenotype of the BN.F344-ApcPirc congenic shows high resistance to cancer. The heterozygous animals get spontaneous intestinal lesions (small intestinal and colonic)starting at 60 days of age in males. BN animals are highly resistant to tumor development and can live over 2 years. Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-02-10) ApcPirc 1554322 18 26732147 26790383 1 - by flanking markers 18 26725560 26820837 1 - by flanking markers 18 27011710 27106323 1 - by flanking markers 18 25828558 25925511 1 - by flanking markers RRID:RRRC_00783 12743627 cNLH-Cat congenital NLH Cataract Rat inbreeding since 2003, juvenile total cataract developed in cNLH line. cNLH = congenital non-learned helpless. congenital non-learned helpless and congenital learned helpless (cLH)lines were developed from outbred Dpargue-Dawley from Charles River. Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-02-10) RRID:RRRC_00702 12743630 BN-Spib spitzenborduere (spib) Retinae display marked rosett formation in the outer nuclear layer; in the funduscopy irregular, dark pigment flecks are observed, which cannot be identified in the histology. Linkage analysis indicating at least two genes interacting. Rat Resource and Research Center mutant Cryopreserved Sperm (as of 2017-02-10) RRID:RRRC_00703 12743640 DA.E3-(RT1-DMa-Ggnbp1) The Tcs1 QTL in DA.E3-(RT1-DMa-Ggnbp1)(DA.1IR85) contains a ~0.5 Mb (min- max 0.43 - 0.63 Mb) insert from DA.1I (RGD:10002743, DA.E3-(D20Rat42-D20Rat49)/Rhd). The inserted fragment spans the MHC-I region but excludes most of the MHC-II region, inclduing the RT1-B and RT1-D genes. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-13) RT1-DMa|Ggnbp1 735053|1359729 20 4843458 5271653 1 - by flanking markers 20 7302036 7690734 1 - by flanking markers 20 3935512 5625320 1 - by flanking markers 20 4707028 5116185 1 - by flanking markers RRID:RRRC_00715 12743645 DA.KHW-(RT1-Db1-RT1-DMb) The Tcs2 QTL in DA.KHW-(RT1-Db1-RT1-DMb)(DA.1HR10) contains a ~0.2 from DA.1H [DA.KHW-RT1h]. The insert spans 12 genes in the MHC-II region, including RT1-B and RT1-D. All genes in the insert have been sequenced and sequences are available at GenBank. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-14) RT1-DMb|RT1-Db1 735096|1593282 20 4671489 4836772 1 - by flanking markers 20 6167759 7295355 1 - by flanking markers 20 3945383 4097190 1 - by flanking markers 20 4548664 4700340 1 - by flanking markers RRID:RRRC_00712 12743647 DA.E3-(Btnl2-RT1-DMb) The Tcs2 QTL in DA.E3-(Btnl2-RT1-DMb)(DA.1UR10) contains a ~0.2 Mb fromDA.E3-(D20Rat47-AA858870)/Rhd (RGD:10002745). The insert spans 12 genes in the MHC-II region, including RT1-B and RT1-D. All genes in the insert have been sequenced and sequences are available from GenBank. The genomic sequences of DA/OlaHsd and E3 have been completed and will be available soon (Backdahl et al. BMC Genomics 2014) Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-14) Btnl2|RT1-DMb 620731|735096 20 4613726 4836772 1 - by flanking markers 20 6221727 7295355 1 - by flanking markers 20 3945383 4156365 1 - by flanking markers 20 4490904 4700340 1 - by flanking markers RRID:RRRC_00713 12743650 DA.AS2-(Tesb-RT1-DMb) DA.F-(Tesb-RT1-DMb) (DA.1FR61) contains a ~0.4 Mb (min- max 0.25 - 0.53 Mb) insert from DA.1F (RGD:2307301). The insert spans 12-19 genes in the MHC-II/MHC-III regions, including RT1-B and RT1-D. The 12 genes in the MHC-II region have been sequenced and sequences are available from GenBank. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-14) RT1-DMb|Tsbp1 735096|1597063 20 4532358 4836772 1 - by flanking markers 20 6258025 7295355 1 - by flanking markers 20 3945383 4235947 1 - by flanking markers 20 4410002 4700340 1 - by flanking markers RRID:RGD_12743650 12743652 DA.KHW-(RT1-DMa-Mln) The Tcs1 QTL in DA.KHW-(RT1-DMa-Mln)(DA.1HR83) contains a ~~0.85 Mb (min - max: 0.61 - 1.08 Mb) insert from DA.1H [DA.KHW-RT1h]. The inserted fragment spans the MHC-I region but excludes most of the MHC-II region, including the RT1-B and RT1-D genes. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-14) RT1-DMa|Mln 735053|1642907 20 4843458 5451752 1 - by flanking markers 20 7302036 8814591 1 - by flanking markers 20 3935512 6571791 1 - by flanking markers 20 4707028 5308948 1 - by flanking markers RRID:RRRC_00716 12743655 DA.E3-(RT1-DMa-Mln) The Tcs1 QTL in DA.E3-(RT1-DMa-Mln)(DA.1UR83) contains a ~0.85 Mb (min - max: 0.61 - 1.08 Mb) insert from DA.1U (RGD:10002745). The inserted fragment spans the MHC-I region but excludes most of the MHC-II region, including the RT1-B and RT1-D genes. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-14) RRID:RRRC_00717 12790593 DA.ACI-(Gtf2ird1-D12Rat8)/Nsi The strain contains the Cia25 R11 recombinant interval introgressed from ACI into DA/Hsd rats through 13 backcrosses. Heterozygous DA.ACI-(Chr12:27462118-Chr12:27611814) [also known as DA.ACI(Cia25) R11] rats were brother-sister mated, and the recombinant strain was maintained in the homozygous state thereafter. North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-16) arthritis/autoimmunity studies Gtf2ird1 620856 12 23319373 23934871 1 - by flanking markers 12 27273535 27805720 1 - by flanking markers 12 25264052 25799259 1 - by flanking markers 12 22254113 22779600 1 - by flanking markers RRID:RRRC_00672 12790595 DA.ACI-(D12Mit2-Gtf2i)/Nsi The strain contains the Cia25 R12 recombinant interval introgressed from ACI into DA/Hsd rats through 13 backcrosses. Heterozygous DA.ACI-(D12Got43-Chr12:27368751)/Nsi [also known as DA.ACI(Cia25) R12] rats were brother-sister mated, and the recombinant strain was maintained in the homozygous state thereafter. North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030, Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-16) arthritis/autoimmunity studies Gtf2i 727961 12 20932559 23545621 1 - by flanking markers 12 24662983 27497928 1 - by flanking markers 12 22650702 25487970 1 - by flanking markers 12 19610870 22476243 1 - by flanking markers RRID:RRRC_00673 12790599 WKY-Asic3em6Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Asic3 gene of WKY/Ncrlrat embryos. The resulting mutation is a 61-bp deletion in the exon 1 of the Asic3 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Asic3em6Mcwi 12790597 4 6125614 6129660 1 - by flanking markers 4 7300219 7304265 1 - by flanking markers 4 7287868 7293295 1 - by flanking markers 4 10760509 10764987 1 - by flanking markers RRID:RGD_12790599 12790602 SS-Axlem1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Axl gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 31-bp deletion in the exon 2 of the Axl gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Axlem1Mcwi 12790600 1 80964751 80994300 1 - by flanking markers 1 83812118 83840542 1 - by flanking markers 1 82550892 82580761 1 - by flanking markers 1 81265656 81296278 1 - by flanking markers RRID:RGD_12790602 12790604 SS-Axlem2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Axl gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 32-bp deletion in the exon 2 of the Axl gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Axlem2Mcwi 12790605 1 80964751 80994300 1 - by flanking markers 1 83812118 83840542 1 - by flanking markers 1 82550892 82580761 1 - by flanking markers 1 81265656 81296278 1 - by flanking markers RRID:RGD_12790604 12790608 SS-Cd14em1Mcwi The CRISPR/Cas9 system was used to introduce a 2-bp deletion in exon 2 of the Cd14 gene of SS/JrHsdMcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Cd14em1Mcwi 12790606 18 29374593 29376190 1 - by flanking markers 18 29265328 29267236 1 - by flanking markers 18 29560341 29562290 1 - by flanking markers 18 28335522 28337383 1 - by flanking markers RRID:RGD_12790608 12790610 SS-Cd14em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Cd14 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a net 7-bp deletion of the Cd14 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Cd14em2Mcwi 12790611 18 29374593 29376190 1 - by flanking markers 18 29265328 29267236 1 - by flanking markers 18 29560341 29562290 1 - by flanking markers 18 28335522 28337383 1 - by flanking markers RRID:RGD_12790610 12790621 SS-Cybbem1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Cybb gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 42-bp deletion in the exon 3 of the Cybb gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm; Cryorecovery (as of 2021-11-03) Cybbem1Mcwi 12790620 X 25514572 25547181 1 - by flanking markers X 15359405 15391317 1 - by flanking markers X 14578330 14610049 1 - by flanking markers X 13360583 13392517 1 - by flanking markers RRID:RGD_12790621 12790623 SS-Cybbem3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Cybb gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 35-bp deletion in the exon 3 of the Cybb gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals; Cryopreserved Sperm (as of 2021-11-03) Cybbem3Mcwi 12790624 X 25514572 25547181 1 - by flanking markers X 15359405 15391317 1 - by flanking markers X 14578330 14610049 1 - by flanking markers X 13360583 13392517 1 - by flanking markers RRID:RGD_12790623 12790627 LEW-Igh-6em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Igh-6 gene of LEW/NCrl rat embryos. The resulting mutation is a 8-bp deletion in the exon 2 of the Igh-6 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Igh-6em1Mcwi 12790625 6 143205627 143206076 1 - by flanking markers RRID:RGD_12790627 12790629 LEW-Igh-6em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Igh-6 gene of LEW/Ncrl rat embryos. The resulting mutation is a 2-bp deletion in the exon 2 of the Igh-6 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Igh-6em4Mcwi 12790630 6 143205627 143206076 1 - by flanking markers RRID:RGD_12790629 12790632 SS-Il2rgem1Mcwi This strain was produced by injecting TALENs targeting the sequence of Il2rg gene into the SS/JrHsdMcwi rat embryos. The resulting mutation is a 19-bp deletion in exon 2. PhysGen Knockouts mutant Live Animals; Cryopreserved Sperm (as of 2021-11-03) Il2rgem1Mcwi 12790633 X 89342055 89345715 1 - by flanking markers X 72017856 72021516 1 - by flanking markers X 71165378 71169078 1 - by flanking markers X 66395330 66399026 1 - by flanking markers RRID:RGD_12790632 12790659 SD-Il2rgem3Mcwi This strain was produced by injecting TALENs targeting the Il2rg gene into Crl:SD rat embryos. The resulting mutation is a 2-bp deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-02-20) Il2rgem3Mcwi 12790660 X 89342055 89345715 1 - by flanking markers X 72017856 72021516 1 - by flanking markers X 71165378 71169078 1 - by flanking markers X 66395330 66399026 1 - by flanking markers RRID:RGD_12790659 12790662 WKY-Mbem6Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Mb gene of WKY/NCrl rat embryos. The resulting mutation is a 25-bp deletion in the exon 2 of the Mb gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Mbem6Mcwi 12790663 7 115087558 115094789 1 - by flanking markers 7 118094391 118101622 1 - by flanking markers 7 118101633 118108864 1 - by flanking markers 7 108759903 108767134 1 - by flanking markers RRID:RGD_12790662 12790676 SS-P2rx1em6Mcwi CRISPR/Cas9 system was used to introduce a mutation in the P2rx1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 2-bp deletion in Exon 2 of the P2rx1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryorecovery (as of 2017-02-20) P2rx1em6Mcwi 12790677 10 59889933 59904985 1 - by flanking markers 10 59305737 59320797 1 - by flanking markers 10 59566268 59581328 1 - by flanking markers 10 57618586 57633648 1 - by flanking markers RRID:RGD_12790676 12790679 PCK-P2rx7em8Mcwi CRISPR/Cas9 system was used to introduce a mutation in the P2rx7 gene of PCK/CrljCrl-Pkhd1pck/Crl rat embryos. The resulting mutation is a 1-bp insertion in Exon 2 of the P2rx7 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Pkhd1pck|P2rx7em8Mcwi 11535943|12790680 9;12 18833903;35074025 19338716;35117152 1 - by flanking markers;1 - by flanking markers 9;12 25025958;41242368 25593163;41808755 1 - by flanking markers;1 - by flanking markers 9;12 26164969;39353613 26736704;39396042 1 - by flanking markers;1 - by flanking markers 9;12 22547396;33889709 23037443;33934168 1 - by flanking markers;1 - by flanking markers RRID:RGD_12790679 12790692 SS-Pon1em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Pon1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp insertion of exon 4 in the Pon1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Pon1em1Mcwi 12790693 4 29936314 29964821 1 - by flanking markers 4 30156712 30183204 1 - by flanking markers 4 30249749 30276297 1 - by flanking markers 4 33294737 33325759 1 - by flanking markers RRID:RGD_12790692 12790695 SS-Pon1em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Pon1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp deletion of exon 5 in the Pon1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Extinct (as of 2017-02-20) Pon1em2Mcwi 12790696 4 29936314 29964821 1 - by flanking markers 4 30156712 30183204 1 - by flanking markers 4 30249749 30276297 1 - by flanking markers 4 33294737 33325759 1 - by flanking markers RRID:RGD_12790695 12790698 SS-Pon1em3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Pon1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp insertion of exon 5 in the Pon1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Pon1em3Mcwi 12790699 4 29936314 29964821 1 - by flanking markers 4 30156712 30183204 1 - by flanking markers 4 30249749 30276297 1 - by flanking markers 4 33294737 33325759 1 - by flanking markers RRID:RGD_12790698 12790702 SS-Pon3em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Pon3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 16-bp deletion of exon 4 in the Pon1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Pon3em1Mcwi 12790703 4 30000505 30027203 1 - by flanking markers 4 30218888 30245586 1 - by flanking markers 4 30311981 30338679 1 - by flanking markers 4 33356983 33383681 1 - by flanking markers RRID:RGD_12790702 12790710 SD-Rag2em3Mcwi This strain was produced by injecting TALENs targeting the sequence into Crl:SD rat embryos. The resulting mutation is a 10-bp deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Rag2em3Mcwi 12790711 3 86764810 86773438 1 - by flanking markers 3 97851318 97859615 1 - by flanking markers 3 91191837 91200134 1 - by flanking markers 3 87902373 87910227 1 - by flanking markers RRID:RGD_12790710 12790713 SS-Rag2em1Mcwi This strain was produced by targeting the Rag2 sequence in SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp deletion in exon 2. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Rag2em1Mcwi 12790714 3 86764810 86773438 1 - by flanking markers 3 97851318 97859615 1 - by flanking markers 3 91191837 91200134 1 - by flanking markers 3 87902373 87910227 1 - by flanking markers RRID:RGD_12790713 12790717 SS-Rfwd2em1Mcwi This strain was produced by targeting the Rfwd2 sequence in SS/JrHsdMcwi rat embryos. The resulting mutation is a 6-bp insertion in exon 4. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Rfwd2em1Mcwi 12790718 13 74552876 74590608 1 - by flanking markers 13 81853391 81986197 1 - by flanking markers 13 76942883 77076015 1 - by flanking markers 13 71467164 71561826 1 - by flanking markers RRID:RGD_12790717 12790721 SS.BN-(D13Rat151-D13Rat197)-Serpinc1em2Mcwi ZFN system was used to introduce a mutation in the Serpinc1 gene of SS.BN-(D13Rat151-D13Rat197)/Mcwi rat embryos. The resulting mutation is a 29-bp deletion in Exon 1 of the Serpinc1 gene. Medical College of Wisconsin, Milwaukee, Wisconsin mutant Live Animals; Cryopreserved Sperm (as of 2021-11-03) Serpinc1em2Mcwi 12790722 13 76548456 76562724 1 - by flanking markers 13 83700761 83715029 1 - by flanking markers 13 78806107 78820375 1 - by flanking markers 13 73257208 73271476 1 - by flanking markers RRID:RGD_12790721 12790944 WKY-Sik2em5Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Sik2 gene of WKY/NCrl rat embryos. The resulting mutation is a 5-bp deletion in exon 4 of the Sik2 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Sik2em5Mcwi 12790945 8 54240307 54337976 1 - by flanking markers 8 53905730 54005295 1 - by flanking markers 8 55309005 55408608 1 - by flanking markers 8 51225543 51325343 1 - by flanking markers RRID:RGD_12790944 12790947 SS-Sorcs2em7Mcwi This strain was produced by injecting ZFNs targeting the sequence of Sorcs2 into SS/JrHsdMcwi rat embryos. The resulting mutation is a 33-bp frameshift deletion in exon 15. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-02-22) Sorcs2em7Mcwi 12790948 14 79968072 80344330 1 - by flanking markers 14 79176694 79547823 1 - by flanking markers 14 79538911 79912333 1 - by flanking markers 14 74371089 74735943 1 - by flanking markers RRID:RGD_12790947 12790950 SS-Sorcs2em9Mcwi This strain was produced by injecting ZFNs targeting the sequence of Sorcs2 into SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp frameshift deletion in exon 15. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2017-02-22) Sorcs2em9Mcwi 12790952 14 79968072 80344330 1 - by flanking markers 14 79176694 79547823 1 - by flanking markers 14 79538911 79912333 1 - by flanking markers 14 74371089 74735943 1 - by flanking markers RRID:RGD_12790950 12790954 WKY-Tertem2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Tert gene of WKY/NCrl rat embryos. The resulting mutation is a 17-bp deletion in Tert gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals (as of 2017-02-22) Tertem2Mcwi 12790955 1 30445180 30465942 1 - by flanking markers 1 33675744 33697542 1 - by flanking markers 1 32250876 32275330 1 - by flanking markers 1 29637213 29659509 1 - by flanking markers RRID:RGD_12790954 12790957 SS.SR-(DXrat11-rs64754598)/Opaz Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains. The SR chromosome X region from DXRat11 to rs64754598 was introgressed on the genetic background of SS. Boston University School of Medicine, Boston, Massachusetts. Rat Resource and Research Center congenic Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-02-22) X 62691290 116944293 1 - by flanking markers X 44619917 99887329 1 - by flanking markers X 44320616 100046443 1 - by flanking markers X 41052407 41052531 1 - by flanking markers RRID:RRRC_00651 12790959 SS.SR-(D1Rat68-rs65309623)/Opaz Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains. The SR chromosome 1 region from D1Rat68 to rs65309623 was introgressed on the genetic background of SS. Boston University School of Medicine, Boston, Massachusetts. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-22) 1 193069836 205671704 1 - by flanking markers 1 212591076 225255286 1 - by flanking markers 1 205603081 218387917 1 - by flanking markers 1 188377360 188377506 1 - by flanking markers RRID:RRRC_00608 12790962 SS.SR-(rs106908358-rs105920659)/Opaz Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains. The SR chromosome 1 region from rs106908358 to rs105920659 was introgressed on the genetic background of SS. Boston University School of Medicine, Boston, Massachusetts. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-22) 1 135112460 135775433 1 - by flanking markers 1 142050355 142050355 1 - by flanking markers 1 141088073 141088073 1 - by flanking markers RRID:RRRC_00609 12790964 SS.SR-(rs66001705-D5Mgh16)/Opaz Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains. The SR chromosome 5 region from rs66001705 to D5Mgh16 was introgressed on the genetic background of SS. Boston University School of Medicine, Boston, Massachusetts. Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2017-02-22) 5 156360938 168006088 1 - by flanking markers 5 159701342 171522762 1 - by flanking markers 5 155945375 167946134 1 - by flanking markers 5 161317276 161317411 1 - by flanking markers RRID:RRRC_00614 12792211 SS.BN-(D13Hmgc1048-D13Hmgc664)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Got45-D13Hmgc664)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 0 0 1 - by flanking markers 13 79688409 79688633 1 - by flanking markers 13 74144915 74145142 1 - by flanking markers RRID:RGD_12792211 12792212 SS.BN-(D13Hmgc1048-D13Hmgc1045)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Got45-D13Hmgc664)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 0 75435694 1 - by flanking markers 13 82670970 82671156 1 - by flanking markers RRID:RGD_12792212 12792213 SS.BN-(D13Hmgc1048-D13Hmgc1050)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Got45-D13Hmgc664)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 0 0 1 - by flanking markers RRID:RGD_12792213 12792214 SS.BN-(D13Hmgc1041-D13Hmgc664)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Got45-D13Hmgc664)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 74586260 74586404 1 - by flanking markers 13 81886999 81887143 1 - by flanking markers 13 79688409 79688633 1 - by flanking markers 13 74144915 74145142 1 - by flanking markers RRID:RGD_12792214 12792216 SS.BN-(D13Hmgc885-D13Hmgc664)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Got45-D13Hmgc664)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 77913594 79688633 1 - by flanking markers 13 72402940 74145142 1 - by flanking markers RRID:RGD_12792216 12792217 SS.BN-(D13Hmgc1041-D13Hmgc885)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Got45-D13Hmgc664)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 74586260 74586404 1 - by flanking markers 13 81886999 81887143 1 - by flanking markers 13 77913594 77913762 1 - by flanking markers 13 72402940 72403109 1 - by flanking markers RRID:RGD_12792217 12792226 SS.BN-(D13Got45-D13Hmgc664)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 69494047 69494326 1 - by flanking markers 13 76974692 76974960 1 - by flanking markers 13 72031440 79688633 1 - by flanking markers 13 66706825 74145142 1 - by flanking markers RRID:RGD_12792226 12792939 SS.BN-(D13Got42-D13Rat61)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 66200668 68034927 1 - by flanking markers 13 73648968 75412480 1 - by flanking markers 13 68686589 70445080 1 - by flanking markers 13 63410813 65170683 1 - by flanking markers RRID:RGD_12792939 12792944 SS.BN-(D13Got42-D13Got45)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 66200668 69494326 1 - by flanking markers 13 73648968 76974960 1 - by flanking markers 13 68686589 72031708 1 - by flanking markers 13 63410813 66707096 1 - by flanking markers RRID:RGD_12792944 12792945 SS.BN-(D13Got42-D13Rat130)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 66200668 72283478 1 - by flanking markers 13 73648968 79590001 1 - by flanking markers 13 68686589 74672607 1 - by flanking markers 13 63410813 69163391 1 - by flanking markers RRID:RGD_12792945 12792946 SS.BN-(D13Got42-D13Hmgc354)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 66200668 66200819 1 - by flanking markers 13 73648968 73649118 1 - by flanking markers 13 68686589 76116817 1 - by flanking markers 13 63410813 70599672 1 - by flanking markers RRID:RGD_12792946 12792947 SS.BN-(D13Got42-D13Hmgc497)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 66200668 66200819 1 - by flanking markers 13 73648968 73649118 1 - by flanking markers 13 68686589 77151580 1 - by flanking markers 13 63410813 71637916 1 - by flanking markers RRID:RGD_12792947 12792948 SS.BN-(D13Got42-D13Hmgc885)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 66200668 66200819 1 - by flanking markers 13 73648968 73649118 1 - by flanking markers 13 68686589 77913762 1 - by flanking markers 13 63410813 72403109 1 - by flanking markers RRID:RGD_12792948 12792949 SS.BN-(D13Got42-D13Hmgc664)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 66200668 66200819 1 - by flanking markers 13 73648968 73649118 1 - by flanking markers 13 68686589 79688633 1 - by flanking markers 13 63410813 74145142 1 - by flanking markers RRID:RGD_12792949 12792950 SS.BN-(D13Mit5-D13Rat32)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 78070512 78189379 1 - by flanking markers 13 85176659 85295746 1 - by flanking markers 13 80285619 80403666 1 - by flanking markers 13 74741916 74862225 1 - by flanking markers RRID:RGD_12792950 12792951 SS.BN-(D13Hmgc5885-D13Rat32)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 78189125 78189379 1 - by flanking markers 13 85295639 85295746 1 - by flanking markers 13 77381168 80403666 1 - by flanking markers 13 71870085 74862225 1 - by flanking markers RRID:RGD_12792951 12792952 SS.BN-(D13Hmgc354-D13Rat32)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 78189125 78189379 1 - by flanking markers 13 85295639 85295746 1 - by flanking markers 13 76116593 80403666 1 - by flanking markers 13 70599447 74862225 1 - by flanking markers RRID:RGD_12792952 12792953 SS.BN-(D13Rat130-D13Rat32)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 72283275 78189379 1 - by flanking markers 13 79589799 85295746 1 - by flanking markers 13 74672405 80403666 1 - by flanking markers 13 69163188 74862225 1 - by flanking markers RRID:RGD_12792953 12792954 SS.BN-(D13Got45-D13Rat32)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat151-D13Rat197)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 69494047 78189379 1 - by flanking markers 13 76974692 85295746 1 - by flanking markers 13 72031440 80403666 1 - by flanking markers 13 66706825 74862225 1 - by flanking markers RRID:RGD_12792954 12798529 SS.BN-(D13Hmgc37-D13Got22)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat111-D13Got22)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13;5 32396527;97701780 45828716;97703112 1 - by flanking markers;1 - by flanking markers 13;5 40757538;100631702 54791605;100633034 1 - by flanking markers;1 - by flanking markers 13;5 35643050;96601805 49720682;96603137 1 - by flanking markers;1 - by flanking markers 13;5 30737550;93541170 30737765;93542503 1 - by flanking markers;1 - by flanking markers RRID:RGD_12798529 12798530 SS.BN-(D13Rat115-D13Got22)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat111-D13Got22)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13;5 35719010;97701780 45828716;97703112 1 - by flanking markers;1 - by flanking markers 13;5 44763184;100631702 54791605;100633034 1 - by flanking markers;1 - by flanking markers 13;5 39639775;96601805 49720682;96603137 1 - by flanking markers;1 - by flanking markers 13;5 34778619;93541170 34778759;93542503 1 - by flanking markers;1 - by flanking markers RRID:RGD_12798530 12798531 SS.BN-(D13Hmgc86-D13Got22)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat111-D13Got22)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13;5 36367611;97701780 45828716;97703112 1 - by flanking markers;1 - by flanking markers 13;5 45412259;100631702 54791605;100633034 1 - by flanking markers;1 - by flanking markers 13;5 40295163;96601805 49720682;96603137 1 - by flanking markers;1 - by flanking markers 13;5 35407990;93541170 35408317;93542503 1 - by flanking markers;1 - by flanking markers RRID:RGD_12798531 12798532 SS.BN-(D13Hmgc40-D13Got22)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat111-D13Got22)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13;5 45828608;97701780 45828716;97703112 1 - by flanking markers;1 - by flanking markers 13;5 48645307;100631702 54791605;100633034 1 - by flanking markers;1 - by flanking markers 13;5 43545977;96601805 49720682;96603137 1 - by flanking markers;1 - by flanking markers 13;5 38744968;93541170 38745230;93542503 1 - by flanking markers;1 - by flanking markers RRID:RGD_12798532 12798533 SS.BN-(D13Hmgc85-D13Got22)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat111-D13Got22)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13;5 45828608;97701780 45828716;97703112 1 - by flanking markers;1 - by flanking markers 13;5 54791498;100631702 54791605;100633034 1 - by flanking markers;1 - by flanking markers 5;13 96601805;44588357 96603137;49720682 1 - by flanking markers;1 - by flanking markers 5 93541170 93542503 1 - by flanking markers RRID:RGD_12798533 12798534 SS.BN-(D13Rat77-D13Got22)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat111-D13Got22)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13;5 45828608;97701780 63175600;97703112 1 - by flanking markers;1 - by flanking markers 13;5 54791498;100631702 71047437;100633034 1 - by flanking markers;1 - by flanking markers 13;5 49720575;96601805 66075827;96603137 1 - by flanking markers;1 - by flanking markers 13;5 60933298;93541170 60933518;93542503 1 - by flanking markers;1 - by flanking markers RRID:RGD_12798534 12798535 SS.BN-(D13Rat111-D13Rat115)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat111-D13Got22)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 32030139 35719148 1 - by flanking markers 13 40421740 44763321 1 - by flanking markers 13 35301263 39639912 1 - by flanking markers 13 30395351 34778759 1 - by flanking markers RRID:RGD_12798535 12798536 SS.BN-(D13Rat111-D13Hmgc86)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat111-D13Got22)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 32030139 36367935 1 - by flanking markers 13 40421740 45412583 1 - by flanking markers 13 35301263 40295487 1 - by flanking markers 13 30395351 35408317 1 - by flanking markers RRID:RGD_12798536 12798537 SS.BN-(D13Rat111-D13Rat20)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat111-D13Got22)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 32030139 38329229 1 - by flanking markers 13 40421740 47267192 1 - by flanking markers 13 35301263 42155682 1 - by flanking markers 13 30395351 37262232 1 - by flanking markers RRID:RGD_12798537 12798538 SS.BN-(D13Rat111-D13Hmgc85)/Mcwi SS/JrHsdMcwi were crossed with SS.BN-(D13Rat111-D13Got22)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 32030139 32030259 1 - by flanking markers 13 40421740 40421859 1 - by flanking markers 13 35301263 44588509 1 - by flanking markers 13 30395351 30395471 1 - by flanking markers RRID:RGD_12798538 12802362 SS.BN-(D13Rat25-RN34_13048990782)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN(D13Rat123-D13Rat101)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 46520126 48990782 1 - by flanking markers 13 55314020 55314194 1 - by flanking markers 13 50260357 50260531 1 - by flanking markers 13 45049404 45049579 1 - by flanking markers RRID:RGD_12802362 12802363 SS.BN-(D13Rat25-rs106935835)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN(D13Rat123-D13Rat101)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 46520126 47031810 1 - by flanking markers 13 55314020 55971123 1 - by flanking markers 13 50260357 50918009 1 - by flanking markers 13 45049404 45049579 1 - by flanking markers RRID:RGD_12802363 12802364 SS.BN-(D13Rat25-rs198199323)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN(D13Rat123-D13Rat101)/Mcwi (RGD:2293145), rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 46520126 47031810 1 - by flanking markers 13 55314020 55971123 1 - by flanking markers 13 50260357 50918009 1 - by flanking markers 13 45049404 45049579 1 - by flanking markers RRID:RGD_12802364 12802365 SS.BN-(D13Hmgc64-D13Hmgc23)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN(D13Rat123-D13Rat101)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 45215472 47299604 1 - by flanking markers 13 54170894 56238470 1 - by flanking markers 13 49102205 51182122 1 - by flanking markers 13 43763752 43763948 1 - by flanking markers RRID:RGD_12802365 12802366 SS.BN-(D13Hmgc64-4582)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN(D13Rat123-D13Rat101)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 45215472 46195314 1 - by flanking markers 13 54170894 54171089 1 - by flanking markers 13 49102205 49102400 1 - by flanking markers 13 43763752 43763948 1 - by flanking markers RRID:RGD_12802366 12802367 SS.BN-(2340-RN34_13048990782)/Mcwi SS/JrHsdMcwi were crossed with SS-13BN(D13Rat123-D13Rat101)/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 47139940 48990782 1 - by flanking markers RRID:RGD_12802367 12859278 Slc:ZUC-Leprfa-/- Zucker fatty rats The spontaneous mutation "obese" (Fatty) was found in the 13M rat stock of Sherman and Merck, by Doctor Lois Zucker, Harriet Bird Memorial Laboratory, Stow, Massachusetts 01775, USA, in 1961.This strain was maintained at Japan SLC, Inc. (Hamamatsu, Japan.) Japan SLC, Inc. (Hamamatsu, Japan) outbred Unknown Lepr|Leprfa 3001|13432153 RRID:RGD_12859278 12859279 Ho:ZFDM-Leprfa Zucker Fatty Diabetes Mellitus rats In the Zucker fatty rat colony in Hoshino Laboratory Animals, Inc, they incidentally found fa/fa homozygous male rats having reproductive ability. The Selective breeding using the fa/fa male rats that exhibited relatively high blood glucose levels at 10 weeks of age, resulting in establishment of a diabetic strain. These fa/fa male rats developed diabetes as early as 10 weeks of age, reaching 100% incidence by 21 weeks of age, while none of the fa/+ male rats developed diabetes. Hoshino Laboratory Animals, Inc. (Ibaraki, Japan) outbred Unknown Lepr|Leprfa 3001|13432153 RRID:RGD_12859279 12859287 ZDF-Leprfa/Drt Zucker Diabetic Fatty Rat "Zucker" fatty rats of undefined outbred background, inbred with selection for non-insulin-dependent diabetes mellitus by mating diabetic homozygous fatty males to heterozygous sisters. Indiana University School of Medicine, Indianapolis. inbred Unknown Lepr 3001 RRID:RGD_12859287 12879386 W-Ghsrem1Ottc The CRISPR/Cas9 genome editing system was used to generate this knock out rat strain with 846- bp deletion in the rat Ghsr gene. The rat strain had Ghsr exon1 deletion in the genome and did not express detectable Ghsr mRNA in brain regions. Optogenetics and Transgenic Technology Core, Rat Resource and Research Center mutant Cryopreserved Sperm; Cryorecovery (as of 2018-12-04) Ghsrem1Ottc 12880435 2 113269623 113272999 1 - by flanking markers 2 132784207 132789319 1 - by flanking markers 2 113065953 113071265 1 - by flanking markers 2 110268489 110271865 1 - by flanking markers RRID:RRRC_00827 12879394 F344-Atmm1Kyo Atm missense rats This strain is an Atm missense mutant (amino acid change of leucine (L) to proline (P) at position 2262 (L2262P))rat and was established by ENU mutagenesis using F344/NSlc strain. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm (as of 2017-04-18) Immunology Atmm1Kyo 12879395 8 56894746 56996565 1 - by flanking markers 8 56598503 56703115 1 - by flanking markers 8 58015938 58119973 1 - by flanking markers 8 53828741 53932773 1 - by flanking markers RRID:RGD_12879394 12879400 F344-Atmem1Kyo ZFN-Atm rats This rat strain was established by ZFN method targeting rat Atm gene (resulting in a 8-bp deletion of exon13). Background strain: F344/Stm. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm (as of 2017-04-18) neurobiology Atmem1Kyo 12879401 8 56894746 56996565 1 - by flanking markers 8 56598503 56703115 1 - by flanking markers 8 58015938 58119973 1 - by flanking markers 8 53828741 53932773 1 - by flanking markers RRID:RGD_12879400 12879423 W-Tg(HCRT-cre-EGFP)B5Ahky orexin-Cre rat This transgenic rat strain was established by Dr. Yamanaka (Nagoya University) in 2012. Background strain: Wistar rat (CLEA Japan). plasmid backbone: pCR2.1. Transgene: human HCRT gene promoter, cre recombinase, EGFP gene, 2A gene. EGFP and cre recombinase are specifically expressed in orexin neurons. National BioResource Project for the Rat in Japan transgenic Unknown RRID:RGD_12879423 12879424 LE-ROSA26em1(CAG-COP4*/EGFP)Kyo This strain was established at Kyoto University. ChR90/EGFP fusion gene sequence under CAG promoter is knock-in at the Rosa26 locus. Background strain: Long-Evans strain (charles river). COP4*: Stigeoclonium helveticum-derived channelrhodopsin (Chronos, ChR90) National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-04-19) RRID:RGD_12879424 12879426 ExHC.BN-(D14Got74-D14Rat132)/Kyu This congenic strain was established by introducing a segment of chromosome14 (D14Got74-D14Rat132 including Smek2 gene) from Brown Norway(BN)/seac strain into ExHC/Seac strain. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo (as of 2017-04-19) 14 103289672 107101727 1 - by flanking markers 14 107489676 110102984 1 - by flanking markers 14 107428559 110402569 1 - by flanking markers 14 96644199 100147478 1 - by flanking markers RRID:RGD_12879426 12879428 WKY.SHRSP-(D1Mgh5-D1Arb21)(D3Rat36-D3Rat144)(D4Mgh7-D4Rat68)/Izm A double congenic strain bade by introducing segments of chromosome 1, 3, and 4 from SHRSP/Izm into WKY/Izm. This strain was established by mating between WKY.SHRSP-(D1Mgh5-D1Arb21)(D3Mgh16-D3Rat144)/Izm(NBRP Rat No:0713)and WKY.SHRSP-(D1Mgh5-D1Arb21) (D4Mgh7-D4Rat68)/IzmCNBRP Rat No:0714). This strain was established and is maintained in Shimane University. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo (as of 2017-04-19) 1;3;4 78134304;78808731;172169471 187092492;151449116;172169650 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 3;1;4 89999731;80946174;200825021 162886090;206277202;233267140 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 3;1;4 83300114;79689548;136351734 156656443;199254774;168998263 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 1;3;4 78430536;80367329;138503169 182418476;149313851;168069246 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers RRID:RGD_12879428 12879431 Jcl:WI Wistar rats This strain is a rat strain originating from the Wistar Institute in Philadelphia (USA). The Wistar Institute was named as a memorial to the famous anatomist Professor Casper Wistar at the University of Pennsylvania. CLEA Japan, Inc. started the production and supply of this strain after it was introduced from Carworth (UK). CLEA Japan, Inc outbred Live Animals (as of 2021-04-22) behavioral pharmacology, toxicity, pharmacology, drug efficacy, and safety testing. RRID:RGD_12879431 12879432 W-Ift140em1Kyo This strain was established by CRISPR/Cas9 system at Kyoto University and introduced to the Institute of Environmental Toxicology. Background strain: Jcl:Wistar. This line 1 (em1) has 2-bp insertion (c.23_24insGG) in the exon 1 of Ift140 (intraflagellar transport 140) gene. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2017-04-19) Ift140em1Kyo 12879433 10 14258556 14348468 1 - by flanking markers 10 14189328 14276940 1 - by flanking markers 10 14373668 14461509 1 - by flanking markers 10 14032665 14121682 1 - by flanking markers RRID:RGD_12879432 12879434 W-Ift140em2Kyo This strain was established by CRISPR/Cas9 system at Kyoto University and introduced to the Institute of Environmental Toxicology. Background strain: Jcl:Wistar. This line 2 (em2) has 2-bp deletion (c.23_24del) in the exon 1 of Ift140 (intraflagellar transport 140) gene. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2017-04-19) Ift140em2Kyo 12879435 RRID:RGD_12879434 12879437 SHC/Ta spontaneously hypercholesterolemic rat This strain (Nephropathy model) was segrigated from SD strain (CLEA Japan,Inc.) by selective mating on the basis of total cholesterol level in blood. National BioResource Project for the Rat in Japan inbred Live Animals (as of 2017-04-19) Metabolism RRID:RGD_12879437 12879438 F344-Tg(CAG-EGFP,Acr-EGFP)2Osb This double transgenic strain was established by co-injection of CAG-EGFP and mouse Acr-EGFP into F344/NSlc at Osaka University (over 5 generations, Dec 2016). There are two lines; GBGS（green body, green sperm）#2 and GBGS #6, but copy numbers and insertion site are not identified. Both lines show enough intensity of GFP fluorescence (no quantitative data). National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2017-04-19) RRID:RGD_12879438 12879439 F344-Tg(CAG-EGFP,Acr-EGFP)6Osb This double transgenic strain was established by co-injection of CAG-EGFP and mouse Acr-EGFP into F344/NSlc at Osaka University (over 5 generations, Dec 2016). There are two lines; GBGS(green body, green sperm)#2 and GBGS #6, but copy numbers and insertion site are not identified. Both lines show enough intensity of GFP fluorescence (no quantitative data). National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2017-04-19) RRID:RGD_12879439 12880021 SD-Apoeem1Sage The mutant rat strain was produced by injecting zinc endonuclease targeting the exon 3 of rat Apoe into Sprague Dawley embryos. This mutant rat has a 16-bp deletion in the gene and resulted in complete loss of Apoe protein in homozygotes. Horizon Discovery mutant Live Animals (as of 2017-05-01) Alzheimer's disease, Neurodegenerative diseases Apoeem1Sage 12880022 1 79003634 79006387 1 - by flanking markers 1 81878372 81882298 1 - by flanking markers 1 80612894 80616820 1 - by flanking markers 1 79353924 79357852 1 - by flanking markers RRID:RGD_12880021 12880026 SD-Appem1Sage This rat model carries a bi-allelic deletion of the amyloid precursor protein (APP) gene. Horizon Discovery mutant Cryopreserved Embryo (as of 2017-05-01) Alzheimer's disease, Neurodegenerative diseases Appem1Sage 12880027 11 24457855 24693851 1 - by flanking markers 11 28048897 28265250 1 - by flanking markers 11 24425013 24641872 1 - by flanking markers 11 24019774 24236584 1 - by flanking markers RRID:RGD_12880026 12880037 SD-Dmdem1Ang This mutant strain was generated by injecting TALEN targeting exon23 of rat Dmd into Crl:SD embryo. The resulting mutant is a 11 bp-deletion in exon 23 leading to a +1 grame shift and premature stop codon 81 bp after the mutation. mutant Unknown Dmdem1Ang 12880032 X 71501362 71671414 1 - by flanking markers X 51475950 53700033 1 - by flanking markers X 51149358 53519271 1 - by flanking markers X 47272324 49504219 1 - by flanking markers RRID:RGD_12880037 12902614 SS.LEW-(D10M11Mit119-D10Rat27)/Ayd A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment. Centre Hospitalier de Universiti de Montrial, Quebec, Canada congenic Unknown 10 77091834 77092169 1 - by flanking markers 10 74127825 74127968 1 - by flanking markers 10 75983662 75983805 1 - by flanking markers 10 73452992 73453136 1 - by flanking markers RRID:RGD_12902614 12902616 SD-Apoetm1(APOE*)Sage These rats were created using CrISPR/Cas9 system to replace the Rat ApoE gene with the Human 4 allele APOE gene Horizon Discovery mutant Live Animals (as of 2017-05-09) Alzheimer's disease, Neurodegenerative diseases APOE 736378 RRID:RGD_12902616 12902621 SD-Bdnfem1Sage+/- This ZFN model contains a monoallelic deletion of the Bdnf gene, encoding for the nerve growth factor protein BDNF. Homozygous animals carrying the Bdnf deletion are postnatal lethal. Reductions of BDNF have been observed in patients with Alzheimer's disease (AD), and this model may be useful for understanding the role of BDNF in AD. Horizon Discovery mutant Live Animals (as of 2017-06-20) Schizophrenia and Alzheimer's Disease Bdnfem1Sage 12902622 3 107371329 107421908 1 - by flanking markers 3 100768637 100819216 1 - by flanking markers 3 96165042 96215621 1 - by flanking markers RRID:RGD_12902621 12902625 SD-Nr1i2em1Sage This ZFN model contains a 20-bp deletion within the Nr1i2 gene. No induction of Cyp3a1 in the model. Horizon Discovery mutant Live Animals (as of 2017-05-09) Xenobiotic Sensors Nr1i2em1Sage 12902626 11 64239918 64276702 1 - by flanking markers 11 67024185 67060494 1 - by flanking markers 11 65022100 65058546 1 - by flanking markers 11 62460213 62496665 1 - by flanking markers RRID:RGD_12902625 12903250 SD-Ahrem1Sage This ZFN model contains a 760-bp deletion in the rat Ahr gene. Horizon Discovery mutant Live Animals (as of 2017-05-10) Xenobiotic Sensors Ahrem1Sage 12903271 6 54205104 54240268 1 - by flanking markers 6 64589066 64624078 1 - by flanking markers 6 54963990 55001806 1 - by flanking markers 6 52234089 52271568 1 - by flanking markers RRID:RGD_12903250 12903251 LH-Chr 17LN/Aek Chr 17 from LN was introgressed onto the genetic background of LH by crossing LH/MRrrcAek male to LN/MRrrcAek female rats. consomic Unknown RRID:RGD_12903251 12903257 LH.LH-Chr 17LN-(rs199194111-rs105876746)/Aek This congenic strain contains a fragment of chromosome 17 from the LH-Chr 17LN/Aek from rs199194111 through rs1056876746 transferred to the LH/MRrrcAek background. Rat Resource & Research Center congenic Unknown 17 83801670 90920974 1 - by flanking markers 17 78329613 85282628 1 - by flanking markers 17 76673662 83549032 1 - by flanking markers RRID:RRRC_00822 12903267 SD-Nr1i3em1Sage This model contains a ZFN-induced 10-bp deletion within rat Nr1i3 gene. Horizon Discovery mutant Live Animals (as of 2017-05-10) Xenobiotic Sensors Nr1i3em1Sage 12903268 13 87104241 87108563 1 - by flanking markers 13 94211961 94218143 1 - by flanking markers 13 89585072 89591278 1 - by flanking markers 13 83632940 83638193 1 - by flanking markers RRID:RGD_12903267 12903270 SD-Nr1i2em1Sage Nr1i3em1Sage This model contains two knockout genes, the 20-bp deletion within rat Nr1i2 and the ZFN-induced 10-bp deletion within rat Nr1i3 gene. Horizon Discovery mutant Live Animals (as of 2017-05-10) Xenobiotic Sensors Nr1i2em1Sage|Nr1i3em1Sage 12902626|12903268 13;11 87104241;64239918 87108563;64276702 1 - by flanking markers;1 - by flanking markers 13;11 94211961;67024185 94218143;67060494 1 - by flanking markers;1 - by flanking markers 13;11 89585072;65022100 89591278;65058546 1 - by flanking markers;1 - by flanking markers 13;11 83632940;62460213 83638193;62496665 1 - by flanking markers;1 - by flanking markers RRID:RGD_12903270 12903272 SD-Nr1i2em1Sage Nr1i3em1Sage Ahrem1Sage This model contains three knockout genes, the 20-bp deletion within rat Nr1i2, the ZFN-induced 10-bp deletion within rat Nr1i3 gene and the 760-bp deletion in the rat Ahr gene. Horizon Discovery mutant Cryopreserved Embryo (as of 2017-05-10) Xenobiotic Sensors Nr1i2em1Sage|Nr1i3em1Sage|Ahrem1Sage 12902626|12903268|12903271 13;11;6 87104241;64239918;54205104 87108563;64276702;54240268 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 11;13;6 67024185;94211961;64589066 67060494;94218143;64624078 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 11;13;6 65022100;89585072;54963990 65058546;89591278;55001806 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 13;11;6 83632940;62460213;52234089 83638193;62496665;52271568 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers RRID:RGD_12903272 12904057 SD-Abcb1aem1Sage -/- SD-Abcb1aem1-/Abcb1aem1- This ZFN model contains biallelic 20 bp deletion within Abcba1 gene. Animals exhibit increased oral bioavailability of P-gp-specific substrates. The homozygous knockout rats display total loss of protein via Western blot. Horizon Discovery mutant Live Animals (as of 2017-05-16) Efflux Transporter Abcb1aem1Sage 12904058 4 21709855 21796628 1 - by flanking markers 4 22276390 22448913 1 - by flanking markers 4 22339829 22517642 1 - by flanking markers 4 25357467 25529941 1 - by flanking markers RRID:RGD_12904057 12904059 SD-(Abcb1a- Abcb1b)em1Sage This model carries knockout of Abcb1a and Abcb1b. Horizon Discovery mutant Live Animals (as of 2017-05-16) Efflux Transporter RRID:RGD_12904059 12904063 SD-Abcg2em1Sage This ZFN model carries a 588-bp deletion within Abcg2 gene. Homozygous knockouts display total loss of protein via Western blot Horizon Discovery mutant Live Animals (as of 2017-05-16) Efflux Transporter Abcg2em1Sage 12904064 4 87502584 87560017 1 - by flanking markers 4 153587206 153712481 1 - by flanking markers 4 88765441 88890268 1 - by flanking markers 4 87676241 87802757 1 - by flanking markers RRID:RGD_12904063 12904679 WKY-Cyp2j4em1Sage/Tja ZFN system was used to introduce a 25-bp deletion mutation in the exon 4 of Cyp2j4 gene of WKY/NCrl rat embryos. This deletion results in premature stop of protein translation. mutant Unknown Cyp2j4em1Sage 12904681 5 116702370 116729722 1 - by flanking markers 5 119130644 123455814 1 - by flanking markers 5 119546458 119564843 1 - by flanking markers 5 111179981 111207490 1 - by flanking markers RRID:RGD_12904679 12904684 SD-Abcb1aem1Sage Abcg2em1Sage This model contains two knockout genes, the 20-bp deletion within rat Abcba1 and the 588-bp deletion within rat Abcg2 gene. Horizon Discovery mutant Live Animals (as of 2017-05-17) Efflux Transporter Abcb1aem1Sage|Abcg2em1Sage 12904058|12904064 4;4 21709855;87502584 21796628;87560017 1 - by flanking markers;1 - by flanking markers 4;4 22276390;153587206 22448913;153712481 1 - by flanking markers;1 - by flanking markers 4;4 22339829;88765441 22517642;88890268 1 - by flanking markers;1 - by flanking markers 4;4 25357467;87676241 25529941;87802757 1 - by flanking markers;1 - by flanking markers RRID:RGD_12904684 12904685 SD-Abcc2em1Sage This ZFN model contains a biallelic 726 bp deletion within the Abcc2 gene. Animals exhibit decreased transport of endogenous glutathione and hyperbilirubinemia. The homozygous knockout rats display total loss of protein via Western blot. Horizon Discovery mutant Live Animals (as of 2017-05-17) Efflux Transporter Abcc2em1Sage 12904687 1 270999832 271057750 1 - by flanking markers 1 263554426 263612556 1 - by flanking markers 1 242664657 242723239 1 - by flanking markers RRID:RGD_12904685 12904730 SD-Abcb11em1Sage This ZFN induced knockout model contains biallelic 8-bp deletion within Abcb11 gene. The homozygous knockout rats display total loss of protein via Western blot. Horizon Discovery mutant Live Animals (as of 2017-05-19) Efflux Transporter Abcb11em1Sage 12904731 3 62091490 62195528 1 - by flanking markers 3 55480024 55587946 1 - by flanking markers 3 54016854 54112797 1 - by flanking markers RRID:RGD_12904730 12904733 SD-Slc22a1em1Sage This ZFN induced knockout model contains 11 bp bi-allelic deletion within exon 1 of the Slc22a1. The homozygous knockout rats display total loss of protein via Western blot. Horizon Discovery mutant Cryopreserved Embryo (as of 2017-05-19) Uptake Transporters Slc22a1em1Sage 12904734 1 42351239 42378295 1 - by flanking markers 1 51452604 51479610 1 - by flanking markers 1 48273639 48300645 1 - by flanking markers 1 48076657 48103679 1 - by flanking markers RRID:RGD_12904733 12904891 SD-Slc22a2em1Sage This ZFN model carries the knockout of the rat Slc22a2. Horizon Discovery mutant Live Animals (as of 2017-05-24) Uptake Transporters Slc22a2 61936 1 42395676 42442847 1 - by flanking markers 1 51394014 51435104 1 - by flanking markers 1 48318025 48360219 1 - by flanking markers 1 48121061 48163268 1 - by flanking markers RRID:RGD_12904891 12904892 SD-Slc22a6em1Sage This ZFN model carries the knockout of the rat Slc22a6. Horizon Discovery mutant Cryopreserved Embryo (as of 2017-05-24) Uptake Transporters Slc22a6 69338 1 211294178 211302398 1 - by flanking markers 1 231761600 231772550 1 - by flanking markers 1 224824809 224833284 1 - by flanking markers 1 205522579 205531179 1 - by flanking markers RRID:RGD_12904892 12904893 SD-Slc22a8em1Sage This ZFN model carries the knockout of the rat Slc22a8. Horizon Discovery mutant Cryopreserved Embryo (as of 2017-05-24) Uptake Transporters RRID:RGD_12904893 12904897 SD-Tp53em1Sage This ZFN model carries the monoallelic 11 base pair deletion in Tp53 gene. Animals exhibit broad tumor spectrum with high degree of tumor malignancy. Horizon Discovery mutant Cryopreserved Embryo (as of 2017-05-24) carcinogenicity Tp53em1Sage 12904898 10 56399721 56411150 1 - by flanking markers 10 55932658 55944087 1 - by flanking markers 10 56186299 56198449 1 - by flanking markers 10 54300070 54311525 1 - by flanking markers RRID:RGD_12904897 12904900 SD-Rag1em1Sage This ZFN model carries a 29 bp deletion within exon 2 of the Rag1 gene on chromosome 3. Homozygous animals display loss of Rag1 protein and loss of B and T cells by FACS analysis. Horizon Discovery mutant Cryopreserved Embryo (as of 2017-05-24) immunology/Inflamation and Immunodeficient Rag1em1Sage 12904901 3 86780782 86791878 1 - by flanking markers 3 97866048 97877145 1 - by flanking markers 3 91206394 91217491 1 - by flanking markers 3 87917061 87928158 1 - by flanking markers RRID:RGD_12904900 12904902 F344-Rag1em1Sage This ZFN model carries a 29 bp deletion within exon 2 of the Rag1 gene on chromosome 3. Rag1 knockout rats lack mature B and T lymphocytes. Horizon Discovery mutant Cryopreserved Embryo (as of 2017-05-24) immunology/Inflamation and Immunodeficient Rag1em1Sage 12904901 3 86780782 86791878 1 - by flanking markers 3 97866048 97877145 1 - by flanking markers 3 91206394 91217491 1 - by flanking markers 3 87917061 87928158 1 - by flanking markers RRID:RGD_12904902 12904903 SD-Rag2em1Sage This ZFN model carries a 2 bp deletion within exon 3 of the Rag2 gene on chromosome 3. Homozygous Rag2 knockout rats display loss of RAG2 protein via Western blot. Homozygous Rag2 knockout rats show loss of B and T cells by FACS analysis. Horizon Discovery mutant Live Animals (as of 2017-05-24) immunology/Inflamation and Immunodeficient Rag2em1Sage 12904904 3 86764810 86773438 1 - by flanking markers 3 97851318 97859615 1 - by flanking markers 3 91191837 91200134 1 - by flanking markers 3 87902373 87910227 1 - by flanking markers RRID:RGD_12904903 12904905 F344-Rag2em1Sage This ZFN model carries a 2 bp deletion within exon 3 of the Rag2 gene.on chromosome 3 Rag2 knockout rats completely lack B and T cells. Horizon Discovery mutant Cryopreserved Embryo (as of 2017-05-24) immunology/Inflamation and Immunodeficient Rag2em1Sage 12904904 3 86764810 86773438 1 - by flanking markers 3 97851318 97859615 1 - by flanking markers 3 91191837 91200134 1 - by flanking markers 3 87902373 87910227 1 - by flanking markers RRID:RGD_12904905 12904907 SD-Prkdcem1Sage This ZFN induced knockout rats carrying a shorter truncated gene, 872 by PCR vs 1627 in wild type, have severe combined immunodeficiency (SCID) and lack of both B and T cells Horizon Discovery mutant Live Animals (as of 2017-05-24) immunology/Inflamation and Immunodeficient Prkdcem1Sage 151232284 11 86951420 87169229 1 - by flanking markers 11 92347175 92565022 1 - by flanking markers 11 89293547 89510948 1 - by flanking markers 11 85040790 85258357 1 - by flanking markers RRID:RGD_12904907 12904908 SD-Ldlrem1Sage In this ZFN induced model, a total of 337 bp were deleted at the junction of intron 3 and exon 4 (on chromosome 8), and 4 bp ccgt were inserted rat Ldlr gene on chromosome 8. Homozygous knockout rats display loss of LDLR protein via Western blot. Homozygous knockout rats have increased body weight as compared to wild type. Homozygous knockout rats show significantly elevated serum cholesterol levels. Horizon Discovery mutant Live Animals (as of 2017-05-24) Ldlrem1Sage 12904909 8 20824040 20846920 1 - by flanking markers 8 22804325 22827199 1 - by flanking markers 8 22750425 22773305 1 - by flanking markers 8 20270020 20292981 1 - by flanking markers RRID:RGD_12904908 12904912 SD-Lepem1Sage-/- This ZFN model possesses a 151 bp deletion spanning exon 1/intron 1 junction of Leptin gene. Homozygous knockout rats display loss of Leptin protein via Western blot. Homozygous knockout rats demonstrate significant weight gain compared to wild type littermates. Homozygous knockout rats show significantly elevated serum cholesterol levels Horizon Discovery mutant Cryopreserved Embryo (as of 2017-05-24) Cardiovascular Lepem1Sage 12904927 4 55943837 55945938 1 - by flanking markers 4 56085079 56099209 1 - by flanking markers 4 56337695 56351818 1 - by flanking markers 4 57661127 57675262 1 - by flanking markers RRID:RGD_12904912 12905029 SD-Thtm1(cre)Sage This ZFN knock in model expresses cre-recombinase under the control of the endogenous tyrosine hydroxylase promoter enabling specific expression in dopaminergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Th. The TH-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery mutant Live Animals (as of 2017-05-31) Optogenetics Rats RRID:RGD_12905029 12905031 SD-Slc6a3tm1(cre)Sage This model expresses cre-recombinase under the control of the endogenous dopamine transporter promoter enabling specific expression in dopaminergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of DAT. The DAT-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery mutant Live Animals (as of 2017-05-31) Optogenetics Rats RRID:RGD_12905031 12905032 LE-Camk2atm1(cre)Sage This model expresses cre-recombinase under the control of the endogenous camkIIa promoter enabling specific expression in excititory neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of CamkIIa. The CamkIIa-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery mutant Live Animals (as of 2017-05-31) Optogenetics Rats RRID:RGD_12905032 12905033 LE-Slc32a1tm1(cre)Sage This model expresses cre-recombinase under the control of the endogenous solute carrier family 32 member 1 (Vgat) promoter enabling specific expression in Vgat positive GABAergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of the Vgat gene. The Vgat-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery mutant Live Animals (as of 2017-05-31) Optogenetics Rats RRID:RGD_12905033 12905034 LE-Viptm1(cre)Sage This model expresses cre-recombinase under the control of the endogenous vasoactive intestinal peptide (VIP) promoter enabling specific expression in VIP positive GABAergic interneurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the VIP gene. The VIP-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery mutant Unknown (as of 2017-05-31) Optogenetics Rats RRID:RGD_12905034 12905035 LE-Tph2tm1(cre)Sage This model expresses cre-recombinase under the control of the endogenous Tryptophan Hydroxylase 2 (Tph2) promoter enabling specific expression in Tph2 positive serotonergic neurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the Tph2 gene. The Tph2-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery mutant Live Animals (as of 2017-05-31) Optogenetics Rats RRID:RGD_12905035 12905036 LE-Htr3atm1(cre)Sage This model expresses cre-recombinase under the control of the endogenous 5 prime-hydroxytryptamine receptor 3A (5Ht3a) promoter enabling specific expression in 5Ht3a positive serotonergic neurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the 5Ht3a gene. The 5Ht3a-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery mutant Live Animals (as of 2017-05-31) Optogenetics Rats RRID:RGD_12905036 12905037 LE-ROSA26em1(CAG-tdTomato)1Sage This CRISPR knock in model possesses the fluorophore tdTomato, sitting behind a floxed stop codon in the Rosa26 locus under control of the CAG promoter. By introducing Cre-recombinase through viral transduction or crossing with one of our Cre-driver rats, tdTomato fluorescence will be observed anywhere Cre- is expressed. The tdTomato Reporter rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with Cre-driver lines. Horizon Discovery mutant Live Animals (as of 2017-05-31) RRID:RGD_12905037 12905038 LE-ROSA26em1(CAG-tdTomato-NpHR)1Sage This CRISPR knock in model possesses the Halorhodopsin fused to TdTomato, sitting behind a floxed stop codon in the Rosa26 locus under the control of the CAG promoter. By introducing Cre-recombinase by crossing with one of our Cre-driver rats, neuronal subtype-specific expression of halorhodopsin and TdTomato will be observed anywhere Cre- is expressed. The Halorhodopsin rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with Cre-driver lines. Horizon Discovery mutant Live Animals (as of 2017-05-31) RRID:RGD_12905038 12907568 WI-Abcb1aem2Sage This model contains biallelic 19- bp deletion in exon 7 of Abcba1 gene. The homozygous knockout rats display total loss of protein via Western blot. mutant Unknown Abcb1aem2Sage 12907569 4 21709855 21796628 1 - by flanking markers 4 22276390 22448913 1 - by flanking markers 4 22339829 22517642 1 - by flanking markers 4 25357467 25529941 1 - by flanking markers RRID:RGD_12907568 12907570 WI-Abcb1aem3Sage This model contains one 19- bp deletion and one 428-bp deletion within Abcba1 gene. The homozygous knockout rats display total loss of protein via Western blot. mutant Unknown Abcb1aem3Sage 12907571 4 21709855 21796628 1 - by flanking markers 4 22276390 22448913 1 - by flanking markers 4 22339829 22517642 1 - by flanking markers 4 25357467 25529941 1 - by flanking markers RRID:RGD_12907570 12910101 SD-Ldlrem1 This model possesses a 19-bp deletion in the seventh exon of the ldlr gene by ZFN method. mutant Unknown Ldlrem1 12910102 8 20824040 20846920 1 - by flanking markers 8 22804325 22827199 1 - by flanking markers 8 22750425 22773305 1 - by flanking markers 8 20270020 20292981 1 - by flanking markers RRID:RGD_12910101 12910127 SD-Tg(Th-Ghsros) This transgenic strain carries a synthetic 108-nucleotide DNA fragment spanning the 5 prime extracellular region of GHS-R was cloned in the antisense orientation driven by tyrosine hydroxylase (Th) promoter. transgenic Unknown Ghsr 621397 RRID:RGD_12910127 12910483 Slc:SD Sprague-Dawley Derived Derived from Charles River Laboratory Inc. USA in 1968. Japan SLC, Inc. outbred Unknown RRID:RGD_12910483 12910493 LEW.1WR1-Ifnar1em1 The CRISPR/Cas9 genome editing system was used to generate this mutant rat strain. The resulting strains carrying a 81-bp deletion in exon 4 of Ifnar1 gene. Department of Medicine, University of Massachusetts Medical School, Worcester, MA mutant Unknown Ifnar1em1 12910495 11 31454789 31478449 1 - by flanking markers 11 35248575 35272235 1 - by flanking markers 11 31640407 31666839 1 - by flanking markers 11 30725774 30752227 1 - by flanking markers RRID:RGD_12910493 12910494 LEW.1WR1-Ifnar1em2 The CRISPR/Cas9 genome editing system was used to generate this mutant rat strain. The resulting strains carrying a 81-bp deletion and 4-bp insertion in exon 4 of Ifnar1 gene. Department of Medicine, University of Massachusetts Medical School, Worcester, MA mutant Unknown Ifnar1em2 12910496 11 31454789 31478449 1 - by flanking markers 11 35248575 35272235 1 - by flanking markers 11 31640407 31666839 1 - by flanking markers 11 30725774 30752227 1 - by flanking markers RRID:RGD_12910494 12910505 SD-Mmp12em2Soar TALEN mediated 607 bp deletion that includes exon 2 of the Mmp12 gene, resulting in a frameshift and premature stop codon mutant Unknown Mmp12em2Soar 12910506 8 4249938 4259675 1 - by flanking markers 8 5610392 5620294 1 - by flanking markers 8 5594717 5616494 1 - by flanking markers 8 4581785 4591687 1 - by flanking markers RRID:RGD_12910505 12910514 SD-Leprem1 This strain was produced by injecting TALEN targeting the sequence of rat Lepr into SD embryos. The resulting mutation is a 57-bp deletion. East China Normal University, Shanghai, China mutant Unknown Leprem1 12910515 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RGD_12910514 12910517 SD-Leprem2 This strain was produced by injecting TALEN targeting the sequence of rat Lepr into SD embryos. The resulting mutation is a 1-bp deletion. East China Normal University, Shanghai, China mutant Unknown Leprem2 12910518 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RGD_12910517 12910519 SD-Leprem3 This strain was produced by injecting TALEN targeting the sequence of rat Lepr into SD embryos. The resulting mutation is a 18-bp insertion. East China Normal University, Shanghai, China mutant Unknown Leprem3 12910546 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RGD_12910519 12910762 BN-KitWs A spontaneous mutant male with a large white spot and coat color dilution was identified in the BN/fMai colony in Yagi Memorial Park (kani-gun, Japan). mutant Unknown KitWs 12910763 14 34906043 34984819 1 - by flanking markers 14 34901860 34979384 1 - by flanking markers 14 35072131 35149638 1 - by flanking markers 14 32547459 32624694 1 - by flanking markers RRID:RGD_12910762 12910940 SD-Cdkn1bwe The multiple endocrine neoplasia (MEN)-like phenotype was initially identified in a Sprague Dawley rat-breeding colony and subsequently maintained by matings between affected and nonaffected littermates. Because cataracts are the first visible sign of the phenotype it was provisionally designated as "Sprague Dawley white eye." The abbreviation SDwe is used to denote animals expressing the mutant phenotype. mutant Unknown Cdkn1bwe 12910941 4 171841705 171846506 1 - by flanking markers 4 232962218 232967323 1 - by flanking markers 4 168689043 168694159 1 - by flanking markers 4 167760067 167765177 1 - by flanking markers RRID:RGD_12910940 13204704 W-Myo7atnd/Hubr Wistar tornado rat Male Wistar founder rats were mutagenized using ENU and mated with untreated female to establish F1 population. Selected F1 progeny were mated to produce F2 and then to breed induced mutation to homozygosity. Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands. mutant Unknown Myo7atnd/Hubr 13204705 1 155292620 155362698 1 - by flanking markers 1 169206150 169276706 1 - by flanking markers 1 163001313 163071545 1 - by flanking markers 1 152342611 152414171 1 - by flanking markers RRID:RGD_13204704 13204756 SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em4Mcwi CRISPR/Cas9 system was used to introduce a 5-bp deletion in exon 2 of the rat Pappa2 gene of SS.BN-(D13Hmgc1048-D13Hmgc1050)/Mcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Pappa2em4Mcwi 13204758 13 74286881 74379736 1 - by flanking markers 13 81303663 81574402 1 - by flanking markers 13 76389150 76660248 1 - by flanking markers 13 70873918 71147874 1 - by flanking markers RRID:RGD_13204756 13204788 SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em5Mcwi CRISPR/Cas9 system was used to introduce a 60-bp deletion in exon 2 of the rat Pappa2 gene of SS.BN-(D13Hmgc1048-D13Hmgc1050)/Mcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals; Cryopreserved Sperm (as of 2021-11-03) Pappa2em5Mcwi 13204789 13 74286881 74379736 1 - by flanking markers 13 81303663 81574402 1 - by flanking markers 13 76389150 76660248 1 - by flanking markers 13 70873918 71147874 1 - by flanking markers RRID:RGD_13204788 13207339 LH.LH-Chr 17LN-(Fanccrgdv551196202-C-rs106387478)/Aek This congenic strain contains a fragment of chromosome 17 from the LH-Chr 17LN/Aek from Fanccrgdv551196202-C through rs106387478 transferred to the LH/MRrrcAek background. Rat Resource & Research Center congenic Unknown 17 7228496 53535067 1 - by flanking markers 17 939418 55648100 1 - by flanking markers 17 946321 47839901 1 - by flanking markers RRID:RRRC_00824 13207341 LH.LH-Chr 17LN-(Fanccrgdv551196202-C-rs107291522)/Aek This congenic strain contains a fragment of chromosome 17 from the LH-Chr 17LN/Aek from Fanccrgdv551196202-C through rs107291522 transferred to the LH/MRrrcAek background. Rat Resource & Research Center congenic Unknown 17 7228496 29903973 1 - by flanking markers 17 939418 26499100 1 - by flanking markers 17 946321 24556663 1 - by flanking markers RRID:RRRC_00825 13207416 LH.LH-Chr 17LN-(rgdv421102132T-rgdv413679765T)/Aek This congenic strain contains a fragment of chromosome 17 from the LH-Chr 17LN/Aek from Fanccrgdv551196202-C through rs106387478 transferred to the LH/MRrrcAek background. Rat Resource & Research Center congenic Unknown 17 30894361 74169166 1 - by flanking markers RRID:RRRC_00826 13207488 LEW-Chrnb4em5Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Chrnb4 gene of LEW/NCrl rat embryos. The resulting mutation is a 4-bp deletion of exon 4 in the Chrnb4 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Chrnb4em5Mcwi 13207489 8 58586961 58605545 1 - by flanking markers 8 58192375 58210959 1 - by flanking markers 8 59610489 59629073 1 - by flanking markers 8 55418379 55436967 1 - by flanking markers RRID:RGD_13207488 13207491 SD-Tg(Col3a1-loxP-eGFP-loxP-TurboRFP)Mcwi Bacterial artificial chromosome (BAC) Transgenic rats containing a Cre-inducible reporter switch from eGFP to TurboRFP under the control of the promoter of Col3a1 (BAC: CH230-401H12 ) MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Cryopreserved Sperm (as of 2018-02-12) RRID:RGD_13207491 13207492 SD-Cd55em6Mcwi CRISPR/Cas9 system was used to introduce a 4-bp deletion of exon 2 in the rat Cd55 gene of Crl:SD embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals (as of 2017-08-02) Cd55em6Mcwi 13207493 13 43322246 43348334 1 - by flanking markers 13 52177543 52206137 1 - by flanking markers 13 47125156 47153557 1 - by flanking markers 13 41857242 41885966 1 - by flanking markers RRID:RGD_13207492 13207494 SD-Cd55em4Mcwi CRISPR/Cas9 system was used to introduce a 22-bp deletion of exon 2 in the rat Cd55 gene of Crl:SD embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Cd55em4Mcwi 13207495 13 43322246 43348334 1 - by flanking markers 13 52177543 52206137 1 - by flanking markers 13 47125156 47153557 1 - by flanking markers 13 41857242 41885966 1 - by flanking markers RRID:RGD_13207494 13207497 SS-Kcnj13em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Kcnj13 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp insertion of exon 2 in the Kcnj13 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Kcnj13em1Mcwi 13207498 9 86206927 86216659 1 - by flanking markers 9 94208941 94224828 1 - by flanking markers 9 94486719 94495333 1 - by flanking markers 9 88063003 88071112 1 - by flanking markers RRID:RGD_13207497 13207501 SS-Nlrp10em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Nlrp10 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 11-bp deletion of exon 2 in the Nlrp10 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Nlrp10em2Mcwi 13207502 1 166411647 166419204 1 - by flanking markers 1 180511615 180519172 1 - by flanking markers 1 173521412 173528969 1 - by flanking markers 1 162922806 162930363 1 - by flanking markers RRID:RGD_13207501 13207503 SS-Nlrp10em3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Nlrp10 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp deletion of exon 2 in the Nlrp10 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Nlrp10em3Mcwi 13207504 1 166411647 166419204 1 - by flanking markers 1 180511615 180519172 1 - by flanking markers 1 173521412 173528969 1 - by flanking markers 1 162922806 162930363 1 - by flanking markers RRID:RGD_13207503 13207507 SS-Nlrp12em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Nlrp12 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 2-bp deletion of exon 3 in the Nlrp12 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Nlrp12em1Mcwi 13207508 1 64242875 64271212 1 - by flanking markers 1 63493575 63521356 1 - by flanking markers 1 64506750 64543908 1 - by flanking markers 1 65932610 65969873 1 - by flanking markers RRID:RGD_13207507 13207509 SS-P2rx1em7Mcwi CRISPR/Cas9 system was used to introduce a mutation in the P2rx1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion in Exon 2 of the P2rx1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm; Cryorecovery (as of 2021-11-03) P2rx1em7Mcwi 13207510 10 59889933 59904985 1 - by flanking markers 10 59305737 59320797 1 - by flanking markers 10 59566268 59581328 1 - by flanking markers 10 57618586 57633648 1 - by flanking markers RRID:RGD_13207509 13207511 SS.BN-(D13Rat151-D13Rat197)-Tg(Slc12a1-Ncf2-2A-Luc)26Mcwi A transgenic rat created by Sleeping Beauty transposon system with proximal tubule-specific overexpression of Ncf2 and Luciferase via a self cleaving 2A peptide, under control of the Slc12a1 (also known as Nkcc2) promoter produced in the line 26 strain. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Cryorecovery (as of 2017-08-03) Ncf2 1309424 RRID:RGD_13207511 13207513 SS-Tg(Slc12a1-Ncf2-2A-Luc)-Ncf2em1Mcwi This is compound transgenic/mutant rat strain derived from the breeding of SS-Tg(Slc12a1-Ncf2-2A-Luc) and SS-Ncf2em1Mcwi. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryorecovery (as of 2017-08-03) Ncf2em1Mcwi 5144089 13 67806516 67834105 1 - by flanking markers 13 75197561 75229600 1 - by flanking markers 13 70226441 70259019 1 - by flanking markers 13 64955502 64986289 1 - by flanking markers RRID:RGD_13207513 13207514 SD-ROSA26em1(Epac-SH187)Mcwi CRISPR/SpCas9 was used to knock in the Epac-SH187, Epac-based FRET sensor into the Rosa26 locus under the control of the endogenous promoter using an Ad2 splice acceptor. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals (as of 2017-08-03) RRID:RGD_13207514 13207516 SD-Rag2em3McwiIl2rgem2Mcwi This strain was produced by crossing of SD-Rag2em3Mcwi and SD-Il2rgem2Mcwi. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Il2rgem2Mcwi|Rag2em3Mcwi 10002792|12790711 3;X 86764810;89342055 86773438;89345715 1 - by flanking markers;1 - by flanking markers 3;X 97851318;72017856 97859615;72021516 1 - by flanking markers;1 - by flanking markers 3;X 91191837;71165378 91200134;71169078 1 - by flanking markers;1 - by flanking markers 3;X 87902373;66395330 87910227;66399026 1 - by flanking markers;1 - by flanking markers RRID:RGD_13207516 13207518 SHR-Hspa1em1Mcwi CRISPR/SpCas9 was used to create indel mutations in Hspa1a, Hspa1b, Hspa1L in SHR/NCrl embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryorecovery (as of 2018-05-01) Hspa1a|Hspa1b|Hspa1l 2840|1593284|1595925 20;20 3945716;3955274 3959552;3957748 1 - by flanking markers;1 - by flanking markers 20;20;20 6956234;7032557;4802576 6962151;7038454;7033025 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 20;20;20 2699707;4879998;4877638 2701856;4965191;4880112 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers 20;20;20 3855104;3870765;3848843 3859148;3873221;3855571 1 - by flanking markers;1 - by flanking markers;1 - by flanking markers RRID:RGD_13207518 13207525 SS-Spp1em3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Spp1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 4-bp deletion in Exon 3 of the Spp1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) spp1em3Mcwi 13207528 14 6653086 6658937 1 - by flanking markers 14 6673686 6679965 1 - by flanking markers 14 5308885 5315120 1 - by flanking markers RRID:RGD_13207525 13207529 SS-Spp1em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Spp1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp deletion in Exon 3 of the Spp1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Spp1em4Mcwi 13207530 14 6653086 6658937 1 - by flanking markers 14 6673686 6679965 1 - by flanking markers 14 5308885 5315120 1 - by flanking markers RRID:RGD_13207529 13207537 SD-Tg(Cdh5-cre)2Mcwi Transgenic rat overexpressing Cre under the control of the Cdh5 (VECadherin) promoter. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Live Animals (as of 2017-08-04) RRID:RGD_13207537 13207551 SS-Tg(Nphs2-cre/ERT2)4Mcwi Transgenic rat overexpressing tamoxifen inducible Cre/ERT2 under the control of the Nphs2 (Podocin) promoter MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Live Animals (as of 2017-08-04) RRID:RGD_13207551 13207560 SS-Tg(Aqp2-cre/ERT2)4Mcwi Transgenic overexpressing tamoxifen inducible cre/ERT2 under the control of the Aquaporin 2 promoter MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Live Animals (as of 2017-08-04) RRID:RGD_13207560 13207563 SS-Tg(Mylpf-cre/ERT2)22Mcwi Transgenic overexpressing tamoxifen inducible CreERT2 under the control of the Mylpf (also known ad Mlc2) promoter MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Live Animals (as of 2017-08-04) RRID:RGD_13207563 13207595 WKY-Tph1em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Tph1 gene of WKY/NCrl rat embryos. The resulting mutation is a 1-bp deletion in the exon 4 of the Tph1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Tph1em1Mcwi 13208230 1 97186071 97207551 1 - by flanking markers 1 103746878 103774100 1 - by flanking markers 1 102669868 102699442 1 - by flanking markers 1 97157375 97178415 1 - by flanking markers RRID:RGD_13207595 13208223 LE-(ROSA26) em1(LTR-nLuc)Ottc The CRISPR/Case9 knock-in rats have cre recombinase-dependent expression of nanoluciferase under the control of HIV LTR promoter inserted to the rat ROSA26 locus. Rat Resource and Research Center mutant Unknown RRID:RRRC_00924 13208224 LE-(ROSA)26 em1(CAG-Cas9)Ottc The CRISPR/Case9 knock-in rats have cre recombinase-dependent expression of Cas9 under the control of CAG promoter inserted to the rat ROSA26 locus. Rat Resource and Research Center mutant Unknown RRID:RRRC_00833 13208231 WKY-Tph1em3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Tph1 gene of WKY/NCrl rat embryos. The resulting mutation is a 1-bp insertion in the exon 4 of the Tph1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Tph1em3Mcwi 13208232 1 97186071 97207551 1 - by flanking markers 1 103746878 103774100 1 - by flanking markers 1 102669868 102699442 1 - by flanking markers 1 97157375 97178415 1 - by flanking markers RRID:RGD_13208231 13208517 SD-Nfe2l2em1Mcwi+/+ SD-Nfe2l2em1Mcwi+/Nfe2l2em1Mcwi+ This strain was produced by injecting TALENs targeting the sequence TAGTCCTGGCGGTGGCAATTCCAAGTCCATCATGCTGAGGGCGGACGCTGCGCTA into Crl:SD Sprague Dawley rat embryos. The resulting mutation is a 41-bp deletion in exon 1.Founders were backcrossed with Crl:SD to get heterozygous offspring which were intercrossed and offspring maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals (as of 2017-08-09) RRID:RGD_13208517 13208518 SD-Nfe2l2em1Mcwi-/- SD-Nfe2l2em1Mcwi-/Nfe2l2em1Mcwi- This strain was produced by injecting TALENs targeting the sequence TAGTCCTGGCGGTGGCAATTCCAAGTCCATCATGCTGAGGGCGGACGCTGCGCTA into Crl:SD Sprague Dawley rat embryos. The resulting mutation is a 41-bp deletion in exon 1.Founders were backcrossed with Crl:SD to get heterozygous offspring which were intercrossed and offspring maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals (as of 2017-08-09) Nfe2l2em1Mcwi 9588549 3 58366693 58394116 1 - by flanking markers 3 69041641 69069190 1 - by flanking markers 3 62497568 62525146 1 - by flanking markers 3 60594239 60621785 1 - by flanking markers RRID:RGD_13208518 13208519 SD-Nfe2l2em1Mcwi+/- SD-Nfe2l2em1Mcwi+/Nfe2l2em1Mcwi- This strain was produced by injecting TALENs targeting the sequence TAGTCCTGGCGGTGGCAATTCCAAGTCCATCATGCTGAGGGCGGACGCTGCGCTA into Crl:SD Sprague Dawley rat embryos. The resulting mutation is a 41-bp deletion in exon 1.Founders were backcrossed with Crl:SD to get heterozygous offspring which were intercrossed and offspring maintained as homozygous and heterozygous breeders. PhysGen Knockouts mutant Live Animals (as of 2017-08-09) RRID:RGD_13208519 13208537 HsdFfyb:WI Descendants of rats from the Wistar Institute, Philadelphia, Pennsylvania then to Harlan (Indianapolis).Since 1995 maintained at Bioterio Central- Facultad de Farmacia y Bioquÿ¿mica de la Universidad de Buenos Aires. Contact: Junin 956 8 piso Ciudad Autÿ¿noma de Buenos Aires, Argentina Tel/Fax: +54 11 5287 4811 Mail: bioterio@ffyb.uba.ar Bioterio Central- Facultad de Farmacia y Bioquÿ¿mica de la Universidad de Buenos Aires. Contact: Junin 956 8 piso Ciudad Autÿ¿noma de Buenos Aires, Argentina Tel/Fax: +54 11 5287 4811 Mail: bioterio@ffyb.uba.ar outbred Live Animals (as of 2017-08-11) RRID:RGD_13208537 13208540 CrlFvetFfyb:SD Descendants of rats from the Charles River Laboratories (USA),then to Fvet at Buenos Aires University and since 2014 maintained at Bioterio Central of Facultad de Farmacia y Bioqu¿mica de la Universidad de Buenos Aires. Junin 956 Ciudad Aut¿noma de Buenos Aires, Argentina Bioterio Central of Facultad de Farmacia y Bioqu¿mica de la Universidad de Buenos Aires. Junin 956 Ciudad Aut¿noma de Buenos Aires, Argentina mutant Live Animals (as of 2017-08-11) RRID:RGD_13208540 13208571 SS-Tg(Cyp11b2-cre/ERT2)2Mcwi Transgenic overexpressing tamoxifen inducible cre/ERT2 under the control of the Cyp11b2 promoter MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Live Animals (as of 2019-04-26) RRID:RGD_13208571 13208576 SS-Tg(Slc5a2-cre/ERT2)2Mcwi Transgenic overexpressing tamoxifen inducible cre/ERT2 under the control of the Slc12a1 (Sglt2) promoter MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Live Animals (as of 2017-08-14) RRID:RGD_13208576 13208583 SS-Tg(Ubc-Wisp2)2Mcwi Transgenic overexpressing Wisp2 under the control of the Ubiqutin C promoter MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Live Animals (as of 2017-08-14) RRID:RGD_13208583 13208584 SS-Tg(Ubc-Wisp2)3Mcwi Transgenic overexpressing Wisp2 under the control of the Ubiqutin C promoter MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Live Animals (as of 2017-08-14) RRID:RGD_13208584 13208842 SS-Ptgs2em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Ptgs2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 53-bp deletion of exon 4 in the Ptgs2 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Ptgs2em1Mcwi 13208843 13 64427288 64432978 1 - by flanking markers 13 72315959 72324483 1 - by flanking markers 13 67351230 67356920 1 - by flanking markers 13 62164080 62169770 1 - by flanking markers RRID:RGD_13208842 13208844 SS-Ptgs2em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Ptgs2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion of exon 4 in the Ptgs2 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Ptgs2em2Mcwi 13208845 13 64427288 64432978 1 - by flanking markers 13 72315959 72324483 1 - by flanking markers 13 67351230 67356920 1 - by flanking markers 13 62164080 62169770 1 - by flanking markers RRID:RGD_13208844 13210578 SD-Lepem1 This CRISPR/Cas9 model possesses a 3 bp(ATC) deletion resulting in the deletion of isoleucine at position 14. The Lep mutant rats exhibited similar mutant phenotypes to Lep and Lepr null rats. mutant Unknown Lepem1 13210580 4 55943837 55945938 1 - by flanking markers 4 56085079 56099209 1 - by flanking markers 4 56337695 56351818 1 - by flanking markers 4 57661127 57675262 1 - by flanking markers RRID:RGD_13210578 13210773 ACI.BN-(Fer1l6rgdv775925951-C-D7Uwm27)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Cryopreserved Sperm (as of 2017-09-07) mammary cancer 7 98507649 98507649 1 - by flanking markers RRID:RGD_13210773 13210774 ACI.BN-(Fer1l6rgdv775925951-C-D7Uwm28)/Shul This congenic strain contains a region of BN/SsNHsd chromosome 7 transferred to the ACI/SegHsd strain background. Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison congenic Unknown mammary cancer 7 98507649 98507649 1 - by flanking markers RRID:RGD_13210774 13432148 SS.ZUC-Leprfa-/-/Slc SS.ZUC-Leprfa/Slc rats were generated as the result of an initial mating of a male Zucker rat (Japan SLC) heterozygous for the fa allele of Lepr with a female DahlS/JrSeac rat (Seac, Japan), followed by multiple rounds of backcrossing of the resulting progeny to the SS strain. congenic Unknown Diabetes Obesity Leprfa 13432153 RRID:RGD_13432148 13432150 SS.ZUC-Leprfa-/+/Slc SS.ZUC-Leprfa/Slc rats were generated as the result of an initial mating of a male Zucker rat (Japan SLC) heterozygous for the fa allele of Lepr with a female DahlS/JrSeac rat (Seac, Japan), followed by multiple rounds of backcrossing of the resulting progeny to the SS strain. congenic Unknown Diabetes Obesity Lepr|Leprfa 3001|13432153 RRID:RGD_13432150 13432151 SS.ZUC-Leprfa+/+/Slc SS.ZUC-Leprfa/Slc rats were generated as the result of an initial mating of a male Zucker rat (Japan SLC) heterozygous for the fa allele of Lepr with a female DahlS/JrSeac rat (Seac, Japan), followed by multiple rounds of backcrossing of the resulting progeny to the SS strain. congenic Unknown Diabetes Obesity Lepr 3001 RRID:RGD_13432151 13432199 SHRSP.WKY-(D3Wox20-D3Rat114)/Gcrc Congenic sub-strains were generated by backcrossing male SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc rats to SHRSP females. Progeny generated from this backcross were heterozygous throughout the original congenic interval. Brother X sister mating was carried out to generate sub-strains containing smaller congenic intervals. Institute of Cardiovascular & Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK congenic Unknown RRID:RGD_13432199 13432200 SHRSP.WKY-(D3Mgh16-D3Rat80)/Gcrc Congenic sub-strains were generated by backcrossing male SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc rats to SHRSP females. Progeny generated from this backcross were heterozygous throughout the original congenic interval. Brother X sister mating was carried out to generate sub-strains containing smaller congenic intervals. Institute of Cardiovascular & Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK congenic Unknown RRID:RGD_13432200 13432201 SHRSP.WKY-(D3Mgh16-D3Wox3)/Gcrc Congenic sub-strains were generated by backcrossing male SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc rats to SHRSP females. Progeny generated from this backcross were heterozygous throughout the original congenic interval. Brother X sister mating was carried out to generate sub-strains containing smaller congenic intervals. Institute of Cardiovascular & Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK congenic Unknown RRID:RGD_13432201 13432202 SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc Congenic sub-strains were generated by backcrossing male SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc rats to SHRSP females. Progeny generated from this backcross were heterozygous throughout the original congenic interval. Brother X sister mating was carried out to generate sub-strains containing smaller congenic intervals. Institute of Cardiovascular & Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK congenic Unknown RRID:RGD_13432202 13432203 SHRSP.WKY-(D3Mgh16-rs197649383)/Gcrc Congenic sub-strains were generated by backcrossing male SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc rats to SHRSP females. Progeny generated from this backcross were heterozygous throughout the original congenic interval. Brother X sister mating was carried out to generate sub-strains containing smaller congenic intervals. Institute of Cardiovascular & Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK congenic Unknown RRID:RGD_13432203 13432204 SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc Congenic sub-strains were generated by backcrossing male SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc rats to SHRSP females. Progeny generated from this backcross were heterozygous throughout the original congenic interval. Brother X sister mating was carried out to generate sub-strains containing smaller congenic intervals. Institute of Cardiovascular & Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK congenic Unknown RRID:RGD_13432204 13437612 SS-Adamts16em1Bj This strain was produced by injecting ZFNs target sequence CCGCGGTTGCTTTGCGCTCTGGGTGCTGTTGCTGGCGCA into Dahl S rat eggs as . The resulting mutation is a 17-bp deletion of the sequence gctctgggtgctgttgc in exon 1. University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614. mutant Unknown Adamts16em1Bj 13437613 17 2559771 2690663 1 - by flanking markers 1 36468949 36599799 1 - by flanking markers 1 35067268 35200530 1 - by flanking markers 1 32430436 32562481 1 - by flanking markers RRID:RGD_13437612 13441557 LE-Tg(Cx3cr1-cre/ERT2)3Ottc This strain was generated by microinjection of LE embyos with a BAC DNA containing the Cx3cr1-cre/ERT2 transgene which is composed of cre/ERT2 recombinase gene driven by the rat genomic Cx3cr1promoter. Rat Resource and Research Center transgenic Unknown RRID:RRRC_00858 13446407 SD-Tg(Camk2a-cre/ERT2)/ZiRrrc The hemizygous rats have random insertion of calcium/calmodulin-dependent protein kinase II alpha (Camk2a)- cre/ERT2 (tamoxifen inducible Cre recombinase) transgene in the genome. This transgenic exhibits expression of cre/ERT2 fusion protein in neural populations where the mouse Camk2a promoter region found in the transgene is active. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2017-11-07) RRID:RRRC_00688 13450922 SD-GEPR-3 Genetically Epilepsy-Prone Rats (GEPR-3) have moderate levels of seizure predisposition. This colony,initially referred to as an AGS (audiogenic response score) colony, was bred to exhibit clonic convulsions (moderate seizures with an ARS of 3) following a single wild running phase in response to sound. Siezures model human generalized tonic/clonic seizures. Rat Resource and Research Center inbred Unknown seizure RRID:RRRC_00798 13451132 BN-Crb1m1 This Brown Norway from Janvier rat strain spontaneously develops progressive focal retinal layer disorganization, loss of photoreceptors, cystic cavitation, and RMG abnormalities associated with early retinal vascular telangiectasia and late stage subretinal neovascularization. This phenotype bears reminiscent of human Macular telangiectasia 2. A deletion insertion mutation in exon 6 of the rat crb1 was identified to be responsible for this retinal phenotype. mutant Unknown Crb1m1 13451133 13 52558317 52725099 1 - by flanking markers 13 61292273 61480872 1 - by flanking markers 13 56270519 56462893 1 - by flanking markers 13 50801484 50989261 1 - by flanking markers RRID:RGD_13451132 13451538 FHH-Chr 1BN-Dusp5em1Mcwi This strain was produced by injecting ZFNs targeting the following sequence CAGGGCAGCCGC-CACtggcaGAAGCTGCGGGAGGA in exon 1 of the rat Dusp5 gene into FHH-Chr 1BN/Mcwi embryos. The resulting mutation is a 14 bp deletion and a 3 bp insertion between nucleotides 449 and 464 in Dusp5 mRNA that creates a frame shift mutation which is predicted to introduce a premature stop codon at amino acid 121. mutant Unknown Dusp5em1Mcwi 13451539 1 259754234 259767645 1 - by flanking markers 1 281658075 281671486 1 - by flanking markers 1 274245184 274258595 1 - by flanking markers 1 252538408 252555320 1 - by flanking markers RRID:RGD_13451538 13452382 SD-Tg(Htt*) This rat model was developed by injection of SD embryos with construct containing rat huntingtin cDNA fragment with 51 CAG repeats (from HD patient) under control of the native rat huntingtin promoter. transgenic Unknown HTT 68472 RRID:RGD_13452382 13452406 SHR/NHsdAkr Spontaneously Hypertensive Rat SHR strain obtained from Harlan Sprague-Dawley (Indianapolis, IN) and maintained at the University of Akron breeding colonies, Akron, Ohio University of Akron breeding colonies, Akron, Ohio inbred Unknown RRID:RGD_13452406 13452407 WKY/NHsdAkr These animals were bought from Harlan Indianapolis, Indiana U.S.A. and maintained at the University of Akron breeding colonies, Akron, Ohio. University of Akron breeding colonies, Akron, Ohio. inbred Unknown RRID:RGD_13452407 13462044 LE-Tg(Thy1-GCaMP6f)9Rrrc Pronuclear injection was used to introduce an expression cassette containing the Thy-1 enhancer and GCaMP6f protein coding sequence. GCaMP6f is a genetically encoded calcium indicator. It is a synthetic fusion of green fluorescent protein, calmodulin, and M13, a peptide sequence from myosin light-chain kinase. Janelia Research Campus and Princeton University, Rat Resource & Research Center transgenic Unknown RRID:RRRC_00829 13462045 LE-Tg(Thy1-GCaMP6f)7Rrrc Pronuclear injection was used to introduce an expression cassette containing the Thy-1 enhancer and GCaMP6f protein coding sequence. GCaMP6f is a genetically encoded calcium indicator. Janelia Research Campus and Princeton University, Rat Resource & Research Center transgenic Live Animals (as of 2021-02-12) RRID:RRRC_00830 13464263 F344-Il2rgem1Iexas This strain was established by CRISPR/Cas9 targeting rat Il2rg gene using electroporation. background strain: F344/Jcl. This strain shows severe combined immunodeficiency (SCID) caused by 5-bp deletion of Il2rg gene. This strain grows normally under SPF condition. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm (as of 2018-01-02) Immunology Il2rgem1Iexas 13464264 X 89342055 89345715 1 - by flanking markers X 72017856 72021516 1 - by flanking markers X 71165378 71169078 1 - by flanking markers X 66395330 66399026 1 - by flanking markers RRID:RGD_13464263 13464268 GH/Htru University of Otago Medical School from rats of Wistar origin imported from England in 1930. Selection for high blood pressure started by Smirk in 1955. A number of sublines have been developed. Closely related to strain AS (Heslop and Phelan 1973). Characteristics Develops hypertension, cardiac hypertrophy and vascular disease (Phelan 1968, Simpson and Phelan 1984, Simpson et al, 1994). National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo (as of 2018-01-02) RRID:RGD_13464268 13464270 Seac:LIS Lister Rat, Sea:Lister Hooded In 1990, this strain was introduced from Harlan Olac (UK) to Seiwa Institute of Experimental Animals. Then this strain was introduced to KYUDO Company in 2004. National BioResource Project for the Rat in Japan outbred Cryopreserved Embryo (as of 2018-01-02) RRID:RGD_13464270 13464272 CrljJclKud:SD In 2004, this strain was introduced from CLEA Japan,Inc to KYUDO company. This strain was maintained and supplied as the SPF animal until April 2016. National BioResource Project for the Rat in Japan outbred Cryopreserved Embryo (as of 2018-01-02) RRID:RGD_13464272 13464273 JclKud:WI Wistar rats In 1977, this strain was introduced from CLEA Japan,Inc to KYUDO company. This strain was maintained and supplied as the SPF animal until April 2016. National BioResource Project for the Rat in Japan outbred Cryopreserved Embryo (as of 2018-01-02) RRID:RGD_13464273 13464320 STOCK Aspaem34Kyo Hcn1A354V/Kyo This double mutant strain was established by crossing WTC/Kyo (NBRP Rat No. 0020) and F344-Aspaem34Kyo (NBRP Rat No. 0806). WTC/Kyo has a missense mutation (Hcn1A354V) in Hcn1 (Hyperpolarization-activated cyclic nucleotide-gated channel 1) gene and F344-Aspaem34Kyo has a 16-bp deletion in the exon4 of Aspa (Aspartoacylase) gene (c.622_637del). National BioResource Project for the Rat in Japan inbred Unknown Aspaem34Kyo|Hcn1A354V 11564348|13464319 RRID:RGD_13464320 13464326 LE.W-Tg(Slc32a1-YFP*)1Yyan/Vip The original strain, W-Tg(Slc32a1-YFP*)1Yyan (NBRP No.0554 rat), was established at National Institute for Physiological Sciences in 2004, thereafter introduced to Gunma University in 2006 （Uematsu et al. Cerebral Cortex (2008). This original strain rats were was crossed with Long-Evans rat (Iar:Long-Evans) for 10 generations to establish the congenic strain. National BioResource Project for the Rat in Japan congenic Cryopreserved Embryo (as of 2018-01-03) RRID:RGD_13464326 13464327 WKY.Cg-clest/Iet When the depositor (The Institute of Environmental Toxicology ) conducted mating experiment using male Crl:CD(SD) rats, the offsprings of backcrossed-generation showed multiple malformations such as ectrodactylism, cleft palate or lip in 2013. These phenotype might be inherited in an autosomal recessive pattern. Therefore the congenic strain was established using WKY strain as the recipient strain. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2018-01-03) RRID:RGD_13464327 13464329 FPL/Iet Fused pulmonary lobes, FPL This spontaneous mutant strain wa found in a colony of Jcl:Wistar strain at the Institute of Environmental Toxicology in 1978: 3 rats out of 13 rats showed fused right pulmonary lobes with reduction deformity of middle pulmonary lobes. These rats also had the syndactylism or paten tof the eyelid. It was difficult to maintain this strain in homozygous condition, mating system has been changed to sib mating between heterozygous rats. National BioResource Project for the Rat in Japan inbred Cryopreserved Embryo (as of 2018-01-03) Frem2fpl 13464330 RRID:RGD_13464329 13503336 W;Cg-Acrtm1Osb Acr KO, Acr {tm1 Osb} After homologous recombination using ES cells derived from hybrid (mix) breed of Slc:Wistar (female) and F344/NSlc (male), Acr KO strain was established by GLT at Osaka University. The genomic region including exon 1 to exon 3 is replaced by Neo resistance gene. After mating with Slc:Wistar, this strain is maintained by sib mating or with Slc:Wistar rats. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2018-01-12) RRID:RGD_13503336 13506176 SS-Nox4em2Ncf2em1Mcwi Breeding together of SS-Nox4em2Mcwi (RGDID: 4139883) and SS-Ncf2em1Mcwi (RGDID: 5144104), both models were generated by ZFN mutagenesis. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm; Cryorecovery (as of 2018-11-12) Nox4em2Mcwi|Ncf2em1Mcwi 4139868|5144089 1;13 143415816;67806516 143603554;67834105 1 - by flanking markers;1 - by flanking markers 1;13 157106652;75197561 157285107;75229600 1 - by flanking markers;1 - by flanking markers 1;13 150796359;70226441 150976186;70259019 1 - by flanking markers;1 - by flanking markers 1;13 140900886;64955502 141078844;64986289 1 - by flanking markers;1 - by flanking markers RRID:RGD_13506176 13506737 GK The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. The GK line was established by repeated inbreeding from Wistar rats selected at the upper limit of normal distribution for glucose tolerance. Repeated selection of rats with tendency to lowest glucose tolerance resulted in clear-cut glucose intolerance after five generations.Until the end of 1980s, GK rats were initiated with breeding pairs in several places and also commercially available from Japanese breeders Charles River Japan, Yokohama, Oriental Yeast, Tokyo, Clea Japan Inc., Osaka (GK/Clea), Japan SLC, Shizuoka (GK/SLC), Takeda Lab Ltd., Osaka (GK/Taked), and from Taconic, USA (GK/Mol/Tac). inbred Unknown RRID:RGD_13506737 13506738 GK/Par The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. The GK line was established by repeated inbreeding from Wistar rats selected at the upper limit of normal distribution for glucose tolerance. Repeated selection of rats with tendency to lowest glucose tolerance resulted in clear-cut glucose intolerance after five generation.In 1988, GK/Par substrain was established in Paris, France by initiating breeding pairs F35 from Japanese colonies . inbred Unknown RRID:RGD_13506738 13506739 GK/Jcl The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. The GK line was established by repeated inbreeding from Wistar rats selected at the upper limit of normal distribution for glucose tolerance. Repeated selection of rats with tendency to lowest glucose tolerance resulted in clear-cut glucose intolerance after five generations.This strain was introduced from Tohoku University, and CLEA Japan Inc started its production and supply as GK/Jcl. CLEA Japan, Inc inbred Unknown RRID:RGD_13506739 13506831 SS-P2rx7em10Mcwi CRISPR/Cas9 system was used to introduce a mutation in the P2rx7 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is an 11-bp putative frame-shift deletion in exon 2 MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-02-21) P2rx7em10Mcwi 13792805 12 35074025 35117152 1 - by flanking markers 12 41242368 41808755 1 - by flanking markers 12 39353613 39396042 1 - by flanking markers 12 33889709 33934168 1 - by flanking markers RRID:RGD_13506831 13506832 SS-P2rx7em13Mcwi CRISPR/Cas9 system was used to introduce a mutation in the P2rx7 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is an 10-bp putative frame-shift deletion in exon 2 MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) P2rx7em13Mcwi 13792806 12 35074025 35117152 1 - by flanking markers 12 41242368 41808755 1 - by flanking markers 12 39353613 39396042 1 - by flanking markers 12 33889709 33934168 1 - by flanking markers RRID:RGD_13506832 13506918 F344/N Fischer Curtiss and Dunning 1920 at Columbia University Institute for Cancer Research, To National Institutes of Health in 1951 (Hansen et al 1982). Subsequent sublines from NIH. NIH Autoimmune Rat Model Repository and Development Center inbred Unknown RRID:RGD_13506918 13506919 F344/Nctr Fischer Curtiss and Dunning 1920 at Columbia University Institute for Cancer Research, To National Center for Toxicological Research, FDA. National Center for Toxicological Research, FDA. inbred Unknown RRID:RGD_13506919 13508588 WI Wistar rat The Wistar rat is an outbred albino rat. This breed was developed at the Wistar Institute in 1906 for use in biological and medical research, and is notably the first rat developed to serve as a model organism. outbred Unknown RRID:RGD_13508588 13513909 SD-Tg(Ren2)27-/- This is a littermate wild type control strain for SD-Tg(Ren2)27 (RGD:629501), which was generated by the mouse Ren2 renin gene along with its 5' and 3' flanking sequences being microinjected into fertilized eggs from a Hannover Sprague-Dawley (SD) background. Center for Genome Research, University of Edinburgh, UK transgenic Unknown RRID:RGD_13513909 13524863 LEC/Crlj Long Evans Cinnamon The LEC/Crlj is available at Japan Charles River Inc. (Yokohama, Japan) since 1991 from the Center for Experimental Plants and Animals, Hokkaido University. Japan Charles River Inc. (Yokohama, Japan) inbred Unknown RRID:RGD_13524863 13524998 UPL In 1989, a femal sprague-Dawley rat with spontaneous cataracts was observed in the Upjohn Pharmaceuticals Limited Tsukuba Research Laboratory colony. The cataract was demonstrated to be hereditary and it was determined that there are two cataract types with different onset ages. inbred Unknown RRID:RGD_13524998 13525002 Gunn rats This mutation was observed for the first time in the breeding stock of the rat colony of the Connaught Laboratories in 1934. It is of Wistar origin. segregating_inbred Unknown RRID:RGD_13525002 13592602 SD-Tg(LRRK2*G2019S)418Rwm These rats were created using BAC constructs consisting of the entire 144kb human LRRK2 locus containing the G2019S mutation and fused to a YPet reporter tag. Rat Resource and Research Center transgenic Cryopreserved Sperm; Cryorecovery (as of 2018-05-14) Parkinson's Disease LRRK2 1353141 RRID:RRRC_00776 13592603 SD-Tg(LRRK2)302Rwn These rats were created using BAC constructs consisting of the entire 144kb human wild type LRRK2 locus fused to a YPet reporter tag. Rat Resource and Research Center transgenic Cryopreserved Sperm; Cryorecovery (as of 2018-05-14) LRRK2 1353141 RRID:RRRC_00778 13592604 SD-Tg(LRRK2*G2019S)416Rwm These rats were created using BAC constructs consisting of the entire 144kb human LRRK2 locus containing the G2019S mutation and fused to a YPet reporter tag. Rat Resource and Research Center transgenic Cryopreserved Sperm; Cryorecovery (as of 2018-05-14) Parkinson's Disease RRID:RRRC_00785 13592605 F344-Tg(CAG-loxP-STOP-loxP-ZsGreen)561Bryd F344-Tg(CAG-loxP-STOP-loxP-ZsGreen)561 The transgene consists of a SpeI fragment from plasmid pCAG-loxPSTOPloxP-ZsGreen (Addgene plasmid #51269, donated by Pawel Pelczar). Hemizygous animals contain approximately 4 copies of the transgene integrated at a site on Chromosome 2. Rat Resource and Research Center transgenic Live Animals (as of 2019-03-18) RRID:RRRC_00797 13602097 LE.Cg-(ROSA26) em1(CAG-Cas9*D10A)Ottc The CRISPR/Case9 knock-in rats have cre recombinase-dependent expression of CRISPR associated protein 9 (Cas9) catalytic mutant protein D10A under the control of CAG promoter inserted to the rat ROSA26 locus. Rat Resource and Research Center mutant Unknown RRID:RRRC_00834 13628730 SD-Il2rgem1Ang TALEN targeting the 2nd exon of rat Il2rg gene was designed and mRNA coding these TALEN was microinjected into Crl:SD embyo.This strain carrying an 80 bp deletion generated a premature stop codon in the 3rd exon. No Il2rg protein was detected by western blot. Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, University de Nantes, Nantes, France. mutant Unknown Il2rgem1Ang 13628731 X 89342055 89345715 1 - by flanking markers X 72017856 72021516 1 - by flanking markers X 71165378 71169078 1 - by flanking markers X 66395330 66399026 1 - by flanking markers RRID:RGD_13628730 13673907 NMcwiWfsm:HS Heterogeneous stock 25 breeding pairs were obtained from Dr. Eva Redei, Northwestern University (Chicago) at 55 breeding generations; these animals exhibit 30% genome-wide heterozygosity which is maintained by using a rotational breeding strategy. These HS rats were derived from NMcwi:HS at the Medical College of Wisconsin and maintained at Wake Forest Baptist Medical Center starting in 2017. Department of Internal Medicine, Molecular Medicine Wake Forest Baptist Medical Center outbred Unknown RRID:RGD_13673907 13702080 SD-Ahrem1Soar Crispr/Cas9 targeted deletion of DNA binding domain of the rat Ahr was injected into the embyos of outbred HsdHot:SD. The established Ahr null strain lacks responsiveness to Ahr ligands. Rat Resource and Research Center mutant Cryopreserved Sperm; Cryorecovery (as of 2019-01-21) Toxicology, reproduction, cancer Ahrem1Soar 13702081 6 54205104 54240268 1 - by flanking markers 6 64589066 64624078 1 - by flanking markers 6 54963990 55001806 1 - by flanking markers 6 52234089 52271568 1 - by flanking markers RRID:RRRC_00831 13702084 BBDP.BBDR-Gimap5/Sunn To generated Gimap5 congenic BBDP/WorSunn rats, the laboratory introgressed the wild-type Gimap5 locus derived from BBDR (BBDR/Wor) rats (Biomedical Research Models) into BBDP/WorSunn rats. Briefly, BBDP/WorSunn and BBDR/Wor rats were crossed, and the resulting F1 animals were backcrossed to BBDP/WorSunn rats. This step was followed by 10 more, marker- assisted backcrosses of Gimap5 heterozygous progeny to BBDP/WorSunn rats. After the eleventh backcross, nonlymphopenic rats were intercrossed, and their progeny homozygous for wild-type Gimap5 were selected for establishing the congenic non-lymphopenic BBDP/WorSunn line (also called BBDP/WorSunn.BBDR-Iddm2). Philippe Poussier,Sunnybrook Research Institute/University of Toronto congenic Unknown Gimap5 628871 RRID:RGD_13702084 13702085 BBDP.BBDR-Gimap5, WF-(D13Rat124-D13Mgh5)/Sunn The Gimap5 congenic BBDP/WorSunn rats (BBDP.BBDR-Gimap5/Sunn) were corssed with the BBDP/WorSunn.WF-CD45 inbred line (BBDP.WF-(D13Rat124-D13Mgh5)/Sunn) to develop an inbred BBDP/WorSunn strain that would be congenic for both wild type Gimap5, hence non T lymphopenic (and consequently diabetes resistant), and for the WF-derived CD45.2 (RT7) allele (the original BBDP/WorSunn strain carries the CD45.1 allele). Department of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada, Rat Resource & Research Center congenic Cryopreserved Sperm; Cryorecovery (as of 2019-03-18) Ptprc|Gimap5 3451|628871 RRID:RRRC_00791 13703119 SD-Lamp2em1 This strain was produced by injecting TALEN targeting exon 2 of rat Lamp2 into SD embryos. The resulting mutation is a 2-bp deletion and results in knockout of Lamp2 protein in Lamp2 y/- male. State Key Laboratory of Cancer Biology, National Clinical Research Centre for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China mutant Unknown Lamp2em1 13703121 X 6908285 6951772 1 - by flanking markers X 124809053 124852509 1 - by flanking markers X 124722628 124766079 1 - by flanking markers X 117173097 117222090 1 - by flanking markers RRID:RGD_13703119 13781890 SD-Rnaset2em1Sage Two pairs of CRISPR guide RNAs were designed to cleave together to delete all 9 exons of RNaseT2. The CRISPR guide RNA and Cas9 mRNA mixtures were microinjected into the pronuclei of fertilized embryos of Sprague-Dawley rats and transferred to pseudopregnant female rats. WT, heterozygous and homozygous (KO) rats were born in the expected Mendelian ratio, and homozygous RNaseT2 KO rats were viable and fertile. mutant Unknown Rnaset2em1Sage 13781891 1 47227491 47244660 1 - by flanking markers 1 54425133 54442302 1 - by flanking markers 1 53174879 53192048 1 - by flanking markers 1 52576344 52603151 1 - by flanking markers RRID:RGD_13781890 13782128 SD-Pde4bem1Sage These ZFN mutant rats were produced by injecting zinc finger nuclease targeting exon 1 of rat Pde4b into Sprague Dawley embryos. The 16-bp frameshift deletion (AGCGGCGTCGCTTCAC) in exon 1 in rat was created in the mutant founders. These mutant founders were backcrossed with Sprague Dawley to produce heterozygous offspring, which were then intercrossed to produce homozygous and heterozygous offspring. Horizon Discovery mutant Cryopreserved Embryo (as of 2018-08-22) Pde4bem1Sage 13782129 5 123158156 123533877 1 - by flanking markers 5 125623815 126001128 1 - by flanking markers 5 121759236 122136814 1 - by flanking markers 5 116799827 117367707 1 - by flanking markers RRID:RGD_13782128 13782146 SD-Bace1em1Sage-/- SD-Bace1em1Sage-/Bace1em1Sage- Bace1 (-/-) rats were generated by SAGE Labs using zinc-finger nuclease (ZFN) technology to create a 137-base pair deletion spanning the translation initiation start site in exon 1 of the rat Bace1 gene, corresponding to chr8:48,766,315-48,766,452 (RGSC 5.0/rn5 assembly) mutant Unknown Bace1em1Sage 13782148 8 48817824 48839681 1 - by flanking markers 8 48766005 48788272 1 - by flanking markers 8 50140092 50162388 1 - by flanking markers 8 46142060 46166268 1 - by flanking markers RRID:RGD_13782146 13782163 SD-Sncatm1(SNCA*)Sage This model contains a knockin of the A53T-mutated SNCA gene deeming the rat SNCA gene non-functional. The knockin contains humanized amino acids for the region spanning amino acids 53-122. The resulting model expresses a humanized A53T alpha-synuclein protein without endogenous rat alpha-synuclein. Horizon Discovery mutant Live Animals (as of 2018-08-24) RRID:RGD_13782163 13782164 SD-Sncaem1Sage This model contains a deletion of the endogenous rat SNCA gene, encoding the alpha-synuclein protein. This model was generated using the CRISPR/Cas9 genome targeting strategy. Horizon Discovery mutant Live Animals (as of 2018-08-24) RRID:RGD_13782164 13782280 SS-Kcnj1em1Kasu+/+ Zinc Finger Nuclease (ZFN) was utilized to knockout rat Kcnj1 function. ZFN constructs targeting the gene were designed and purchased from Sigma Aldrich (St. Louis, MO, USA). The targeting site sequence is CTCAAGTGACCATAGGTTACGgattcaGGTTTGTGAC (lower case represents the ZFN cleavage site). Kcnj1 knockout founders were generated by microinjection of ZFN mRNAs into single-cell SS (from Harlan) rat embryos. The resulting mutation is 209 bp deletion from G225 to G433, leading to frameshift and premature termination of Kcnj1 protein. This strain is the wild type littermate from heterozygous cross. Departments of Cardiovascular Diseases, Merck Research Laboratories, Merck&Co.,Inc mutant Unknown RRID:RGD_13782280 13782351 SS-Kcnj1em1Kasu+/- Zinc Finger Nuclease (ZFN) was utilized to knockout rat Kcnj1 function. ZFN constructs targeting the gene were designed and purchased from Sigma Aldrich (St. Louis, MO, USA). The targeting site sequence is TCAAGTGACCATAGGTTACGgattcaGGTTTGTGAC (lower case represents the ZFN cleavage site). Kcnj1 knockout founders were generated by microinjection of ZFN mRNAs into single -cell SS (from Harlan) rat embryos. The resulting mutation is 209 bp deletion from G225 to G433, leading to frameshift and premature termination of Kcnj1 protein in homozygotes. Departments of Cardiovascular Diseases, Merck Research Laboratories, Merck&Co.,Inc mutant Unknown Kcnj1em1Kasu 13782352 8 32158243 32162370 1 - by flanking markers 8 33453597 33454750 1 - by flanking markers 8 33490280 33519127 1 - by flanking markers 8 30779883 30808607 1 - by flanking markers RRID:RGD_13782351 13782353 SS-Kcnj1em1Kasu-/- Zinc Finger Nuclease (ZFN) was utilized to knockout rat Kcnj1 function. ZFN constructs targeting the gene were designed and purchased from Sigma Aldrich (St. Louis, MO, USA). The targeting site sequence is CTCAAGTGACCATAGGTTACGgattcaGGTTTGTGAC (lower case represents the ZFN cleavage site). Kcnj1 knockout founders were generated by microinjection of ZFN mRNAs into single-cell SS (from Harlan) rat embryos. The resulting mutation is 209 bp deletion from G225 to G433, leading to frameshift and premature termination of Kcnj1 protein in homozygotes. Departments of Cardiovascular Diseases, Merck Research Laboratories, Merck&Co.,Inc mutant Unknown Kcnj1em1Kasu 13782352 8 32158243 32162370 1 - by flanking markers 8 33453597 33454750 1 - by flanking markers 8 33490280 33519127 1 - by flanking markers 8 30779883 30808607 1 - by flanking markers RRID:RGD_13782353 13782371 SD-Cacna1f csnb congenital stationary night blindness rat A naturally-occurring mutation in Cacna1f was identified in a male Sprague Dawley rat with the phenotype of congenital stationary night blindness.Sequence analysis revealed a point mutation of C to T at position 2941, which changes codon 981 from arginine (CGA) to a stop codon (TGA). This R981Stop point mutation was predicted to lead to a version of protein shortened by a total of 999 amino acids, and missing the C-terminal and, in particular, part of the third and all of the fourth ion transport domains. mutant Unknown Cacna1f csnb 13782372 X 26908850 26937165 1 - by flanking markers X 16504174 16532670 1 - by flanking markers X 15712709 15741135 1 - by flanking markers X 14868096 14896413 1 - by flanking markers RRID:RGD_13782371 13792570 WI-Oprl1m1Hubr+/- The original mutants were created by target-selected ENU-induced mutagenesis in a Brown Norway background. The animals were outcrossed for two generations on a Brown Norway background. they were subsequently backcrossed on a Wistar (Crl:WI) background for four generations. Backcrossings were performed to eliminate possible additional mutations induced by ENU-mutagenesis. Heterozygous oprl1+/- rats were crossed to generate the experimental animals. A C to G transversion at position 3657 in the oprl1 gene (ENSRNOG00000016768), resulting into a premature stop codon (TAC>TAG) in the third exon. Hubrecht Laboratory, Utrecht, The Netherlands mutant Unknown Oprl1m1Hubr 13792571 3 170869862 170873417 1 - by flanking markers 3 180932344 180943574 1 - by flanking markers 3 177223779 177231663 1 - by flanking markers 3 168831934 168839920 1 - by flanking markers RRID:RGD_13792570 13792572 WI-Oprl1m1Hubr-/- NOPr knockout rat The original mutants were created by target-selected ENU-induced mutagenesis in a Brown Norway background. The animals were outcrossed for two generations on a Brown Norway background. they were subsequently backcrossed on a Wistar (Crl:WI) background for four generations. Backcrossings were performed to eliminate possible additional mutations induced by ENU-mutagenesis. Heterozygous oprl1+/- rats were crossed to generate the experimental animals. A C to G transversion at position 3657 in the oprl1 gene (ENSRNOG00000016768), resulting into a premature stop codon (TAC>TAG) in the third exon.NOPr is completely absent in homozygous mutants. Hubrecht Laboratory, Utrecht, The Netherlands mutant Unknown Oprl1m1Hubr 13792571 3 170869862 170873417 1 - by flanking markers 3 180932344 180943574 1 - by flanking markers 3 177223779 177231663 1 - by flanking markers 3 168831934 168839920 1 - by flanking markers RRID:RGD_13792572 13792573 SD-Lepem1Sage+/- This ZFN model possesses a 151 bp deletion spanning exon 1/intron 1 junction of Leptin gene. Homozygous knockout rats display loss of Leptin protein via Western blot. Homozygous knockout rats demonstrate significant weight gain compared to wild type littermates. Homozygous knockout rats show significantly elevated serum cholesterol levels Horizon Discovery mutant Cryopreserved Embryo (as of 2018-09-13) Cardiovascular Lepem1Sage 12904927 4 55943837 55945938 1 - by flanking markers 4 56085079 56099209 1 - by flanking markers 4 56337695 56351818 1 - by flanking markers 4 57661127 57675262 1 - by flanking markers RRID:RGD_13792573 13792575 SD-Lepem1Sage+/+ These wild type rats are littermates of homozygous knockout rats from heterozygote matings. The Lepr knockout model possesses a 151 bp deletion spanning the exon 1/intron 1 junction of the Leptin gene. Homozygous knockout rats display loss of Leptin protein via Western blot. Homozygous knockout rats demonstrate significant weight gain compared to wild type littermates. Homozygous knockout rats show significantly elevated serum cholesterol levels mutant Unknown (as of 2018-09-13) Cardiovascular RRID:RGD_13792575 13792606 SD-Cd59em1Ask-/- SD-Cd59em1-/Cd59em1- The CRISPR/Cas9 genome editing system was used to generate Cd59 mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 3 of the rat Cd59 created a 11 bp-deletion (TGCAAAACAAA) in exon 3. No protein expression was detected in the blood smear of homozygous mutants. Cardiovascular Research Institute,University of California San Francisco, CA 94143-0521 USA mutant Unknown Cd59em1Ask 13792720 3 89243600 89245129 1 - by flanking markers 3 100650411 100668036 1 - by flanking markers 3 94010481 94028660 1 - by flanking markers 3 90459085 90477571 1 - by flanking markers RRID:RGD_13792606 13792607 SD-Cd59em1Ask+/+ The CRISPR/Cas9 genome editing system was used to generate Cd59 mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 3 of the rat Cd59 created a 11 bp-deletion in exon 3. No protein expression was detected in the blood smear of homozygous mutants. Breeding of CD59 +/- rats was done to generate wildtype (CD59+/+)and homozygous mutant (CD59-/-) rats. Cardiovascular Research Institute,University of California San Francisco, CA 94143-0521 USA mutant Unknown RRID:RGD_13792607 13792682 SD-Abcc6em2Qlju+/- This strain was produced by injecting ZFNs into SD embryos. ZFNs were designed to target exon 1 of rat Abcc6 gene at the binding site/cutting site 5-CACGCCTGGAGAGTCCTGcgcaggCCTGAGGGTGAGTCC-3 (c.24-c.62). The resulting mutation is a 23 bp-deletion (TGCGCAGGCCTGAGGGTGAGTCC) from the first coding exon of the rat Abcc6 gene. The mutation is predicted to cause out of frame translation and a premature stop codon. No protein in the homozygous mutant was detected by immunostaining. Thomas Jefferson University, Philadelphia mutant Unknown Abcc6em2Qlju 10413846 1 96448588 96524655 1 - by flanking markers 1 103042723 103096453 1 - by flanking markers 1 101954786 102013252 1 - by flanking markers 1 96447224 96501464 1 - by flanking markers RRID:RGD_13792682 13792683 SD-Abcc6em2Qlju+/+ This strain was produced by injecting ZFNs into SD embryos. ZFNs were designed to target exon 1 of rat Abcc6 gene at the binding site/cutting site 5-CACGCCTGGAGAGTCCTGcgcaggCCTGAGGGTGAGTCC-3 (c.24-c.62). The resulting mutation is a 23 bp-deletion (TGCGCAGGCCTGAGGGTGAGTCC) from the first coding exon of the rat Abcc6 gene. This wild type mutant is the wild type offspring from the cross of heterozygous mutants. Thomas Jefferson University, Philadelphia mutant Unknown RRID:RGD_13792683 13792701 SD-Trpv1em1Sage-/- These ZFN mutant rats were produced by injecting zinc finger nuclease targeting exon 13 of rat Trpv1 into Sprague Dawley embryos. A 2-bp (CA) frameshift deletion in exon 13 was created. Homozygous knockout rats exhibit complete loss of Trpv1 protein. Horizon Discovery mutant Cryopreserved Embryo (as of 2018-09-21) Trpv1em1Sage 13792702 10 60109656 60134939 1 - by flanking markers 10 59538296 59563441 1 - by flanking markers 10 59799123 59824208 1 - by flanking markers 10 57851428 57876513 1 - by flanking markers RRID:RGD_13792701 13792705 SD-Trpv1em1Sage+/+ These ZFN mutant rats were produced by injecting zinc finger nuclease targeting exon 13 of rat Trpv1 into Sprague Dawley embryos. A 2-bp (CA) frameshift deletion in exon 13 was created ( SD-Trpv1em1Sage-/-). This wild type mutant is the wild type offspring from the cross of heterozygous mutants. mutant Unknown RRID:RGD_13792705 13792727 HanRj:WI Zentralinstitut fur Versuchstierzucht (Hannover) 1982 (from Allington Farm - UK 1964). This strain was selected by DONALDSON in 1906 at the Wistar Institute (USA), from a batch belonging to Chicago University (RUSSEL-LINDSAY, 1979). Janvier Labs outbred Unknown RRID:RGD_13792727 13792794 SD-Fhem1+/- A pair of TALENs targeting exon 1 of the Fh gene was injected into SD embryos to create Fh knock out mutants. The resulting mutation was an 11-bp deletion (acacctttggt) on exon 1 that caused premature stop of FH protein. No homozygous -/- mutant was revealed in litters. mutant Unknown Fhem1 13792797 13 91329837 91355722 1 - by flanking markers 13 98116496 98142636 1 - by flanking markers 13 93651486 93677371 1 - by flanking markers 13 87524331 87550215 1 - by flanking markers RRID:RGD_13792794 13792795 SD-Fhem1+/+ A pair of TALENs targeting exon 1 of the Fh gene was injected into SD embryos to create Fh knock out mutants. The resulting mutation was an 11-bp deletion (acacctttggt) on exon 1 that caused premature stop of FH protein. Breeding of Fh +/- rats was done to generate wildtype (Fh+/+)and Fh (+/-). No homozygous mutant were observed. mutant Unknown RRID:RGD_13792795 13792801 SS-Nlrp3em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Nlrp3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp deletion of exon 1 in the Nlrp3 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-09-28) Nlrp3em2Mcwi 13792799 10 45850224 45874533 1 - by flanking markers 10 45648191 45674617 1 - by flanking markers 10 45884324 45918290 1 - by flanking markers 10 44326770 44353814 1 - by flanking markers RRID:RGD_13792801 13792803 SS-P2rx7em12Mcwi This allele was made by CRISPR/Cas9 system. The resulting mutation is a 10-bp insertion in Exon 2 of the P2rx7 gene. mutant Cryopreserved Sperm (as of 2021-11-03) P2rx7em12Mcwi 13792802 12 35074025 35117152 1 - by flanking markers 12 41242368 41808755 1 - by flanking markers 12 39353613 39396042 1 - by flanking markers 12 33889709 33934168 1 - by flanking markers RRID:RGD_13792803 13792808 SS-Ptk2bem1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Ptk2b gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp deletion in exon 2. mutant Cryopreserved Sperm (as of 2021-11-03) Ptk2bem1Mcwi 13792810 15 45589222 45717866 1 - by flanking markers 15 48646476 48766708 1 - by flanking markers 15 42827306 42947796 1 - by flanking markers 15 40360722 40481235 1 - by flanking markers RRID:RGD_13792808 13792811 SS-Ptk2bem3Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Ptk2b gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a7-bp deletion in exon 2. mutant Unknown Ptk2bem3Mcwi 13792812 RRID:RGD_13792811 13792813 SHRSP-Spp1em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Spp1 gene of SHRSP/A3NCrl rat embryos. The resulting mutation is a 11-bp deletion in Exon 3 of the Spp1 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-01) Spp1em2Mcwi 13792814 14 6653086 6658937 1 - by flanking markers 14 6673686 6679965 1 - by flanking markers 14 5308885 5315120 1 - by flanking markers RRID:RGD_13792813 13792821 SD-Tg(CAG-loxP-stop-loxP-Drp1-GFP)1Mcwi SD-Tg(CAG-loxP-stop-loxP-Drp1-GFP)1 The Sleeping Beauty transposon system was used to introduce a Drp1-GFP fusion driven by a ubiquitous promoter, interupted by a floxed stop cassette. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Unknown RRID:RGD_13792821 13792822 SD-Tg(CAG-loxP-stop-loxP-Drp1-GFP)2Mcwi SD-Tg(CAG-loxP-stop-loxP-Drp1-GFP)2 The Sleeping Beauty transposon system was used to introduce a Drp1-GFP fusion driven by a ubiquitous promoter, interupted by a floxed stop cassette.This is line B. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Unknown RRID:RGD_13792822 13792823 SD-Tg(CAG-loxP-stop-loxP-Drp1-GFP)3Mcwi The Sleeping Beauty transposon system was used to introduce a Drp1-GFP fusion driven by a ubiquitous promoter, interupted by a floxed stop cassette.This is line C. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Unknown RRID:RGD_13792823 13792825 SD-Tg(CAG-loxP-stop-loxP-Mfn1-GFP)1Mcwi The Sleeping Beauty transposon system was used to introduce a Mfn1-GFP fusion driven by a ubiquitous promoter, interupted by a floxed stop cassette. This is line A. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Unknown RRID:RGD_13792825 13792827 WKY-Tg(Ubc-cre/ERT2)4Mcwi The Sleeping Beauty transposon system was used to introduce a cre-ERT2 fusion, driven by the UbC promoter. This is line D.Cre activity is detected even without tamoxifen induction. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Cryopreserved Sperm (as of 2018-10-02) RRID:RGD_13792827 13792828 WKY-Tg(Ubc-cre/ERT2)5Mcwi The Sleeping Beauty transposon system was used to introduce a cre-ERT2 fusion, driven by the UbC promoter. This is line E.Cre activity is detected even without tamoxifen induction. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Cryopreserved Sperm (as of 2018-10-02) RRID:RGD_13792828 13793372 SS-Tlr4em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Tlr4 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp deletion in exon 2. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown Tlr4em1Mcwi 13793373 RRID:RGD_13793372 13793374 DA-Tph1em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Tph1 gene of DA/MolTac rat embryos. The resulting mutation is a 1-bp deletion in exon 4. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-03) Tph1em4Mcwi 13793375 1 97186071 97207551 1 - by flanking markers 1 103746878 103774100 1 - by flanking markers 1 102669868 102699442 1 - by flanking markers 1 97157375 97178415 1 - by flanking markers RRID:RGD_13793374 13793376 SS-Avpr2em4Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Avpr2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 30-bp deletion in exon 2. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Embryo (as of 2018-10-03) Avpr2em4Mcwi 13793377 X 159821860 159823488 1 - by flanking markers 1 152637074 152640726 1 - by flanking markers X 156889006 156892707 1 - by flanking markers X 151633501 151636000 1 - by flanking markers RRID:RGD_13793376 13793378 SS-Avpr2em5Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Avpr2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 9-bp deletion in exon 2. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-03) Avpr2em5Mcwi 13793379 X 159821860 159823488 1 - by flanking markers 1 152637074 152640726 1 - by flanking markers X 156889006 156892707 1 - by flanking markers X 151633501 151636000 1 - by flanking markers RRID:RGD_13793378 13799346 SS-Cgnl1em1Mcwi CRISPR/Cas9 system was used to introduce a 80-bp deletion on exon 2 of Cgnl1 gene in SS/JrHsdMcwi embryos MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-10) Cgnl1em1Mcwi 13799347 8 76088865 76241145 1 - by flanking markers 8 74800532 74950938 1 - by flanking markers 8 78126670 78278490 1 - by flanking markers 8 72273401 72424842 1 - by flanking markers RRID:RGD_13799346 13799348 SS-Cgnl1em2Mcwi CRISPR/Cas9 system was used to introduce a 88-bp deletion on exon 2 of Cgnl1 gene in SS/JrHsdMcwi embryos MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-10) Cgnl1em2Mcwi 13799349 8 76088865 76241145 1 - by flanking markers 8 74800532 74950938 1 - by flanking markers 8 78126670 78278490 1 - by flanking markers 8 72273401 72424842 1 - by flanking markers RRID:RGD_13799348 13799350 T2DN-F2rem1Mcwi CRISPR/Cas9 system was used to introduce a 2-bp deletion in exon 1 of F2r gene in the T2DN/Mcwi embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-10) F2rem1Mcwi 13799351 2 25985800 25989072 1 - by flanking markers 2 45254489 45257761 1 - by flanking markers 2 26118760 26135340 1 - by flanking markers 2 26869343 26885856 1 - by flanking markers RRID:RGD_13799350 13800555 F344/IcoCrl From mating #344 of rats purchased from a local breeder (Fischer). The colony was originated by M. R. Curtis, Columbia University in 1920. To the Germ-Free Animal Laboratory at CNRS, Gif-sur-Yvette, France from the Lobund Institute, University of Notre-Dame, South Bend, Indiana, U.S.A. Subsequently introduced to Charles River France in 1970 as an axenic colony. Charles River inbred Unknown RRID:RGD_13800555 13800556 F344-Hsd11b2em1Jmul-/- F344-Hsd11b2em1Jmul-/Hsd11b2em1Jmul- The ZFN system targeting exon 2 of Hsd11b2 gene was injected into the F344/IcoCrl embryos to induce a 123-bp deletion removing the 3' end of exon 2 and the first 16-bp of intron B and create a premature stop coden TAG. mutant Unknown Hsd11b2em1Jmul 13800560 19 35336342 35341585 1 - by flanking markers 19 48341841 48347084 1 - by flanking markers 19 37476083 37481326 1 - by flanking markers 19 33397656 33402899 1 - by flanking markers RRID:RGD_13800556 13800557 F344-Hsd11b2em1Jmul+/+ F344-Hsd11b2em1Jmul+/Hsd11b2em1Jmul+ This is the wild-type litter mates of the Hsd11b2 F344 mutants created by ZFN system targeting exon 2 of Hsd11b2 gene was injected into the F344/IcoCrl embryos to induce a 123-bp deletion removing the 3' end of exon 2 and the first 16-bp of intron B and create a premature stop coden TAG. mutant Unknown RRID:RGD_13800557 13800746 SS-F8em1Mcwi CRISPR/Cas9 system was used to delete the entire F8 gene in the SS/JrHsdMcwi embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-17) F8em1Mcwi 13800747 18 121134 162008 1 - by flanking markers 18 413447 444491 1 - by flanking markers 18 367862 399242 1 - by flanking markers 18 140848 172330 1 - by flanking markers RRID:RGD_13800746 13800749 Lew-Glp1rem1Mcwi CRISPR/Cas9 system was used to introduce a 84-bp deletion and skipping of exon 5 of the Glp1r gene in Lew/NCrl embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown Glp1rem1Mcwi 13800750 20 9225881 9264184 1 - by flanking markers 20 11768479 11808416 1 - by flanking markers 20 9586075 9626228 1 - by flanking markers 20 8972004 9010241 1 - by flanking markers RRID:RGD_13800749 13800810 SS-Kcnq1em5Mcwi CRISPR/Cas9 system and the single-stranded oligodeoxynucleotide (ssODN ) were combined to introduce the R231H mutation in the Kcnq1 gene of SS/JrHsdMcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-10-18) Kcnq1em5Mcwi 13800813 1 203383401 203803687 1 - by flanking markers 1 223154713 223490458 1 - by flanking markers 1 216293087 216630339 1 - by flanking markers 1 198291711 198624683 1 - by flanking markers RRID:RGD_13800810 13800825 FHH-Muc1em1Mcwi CRISPR/Cas9 system was used to introduce a 2-bp deletion in exon 2 of rat Muc1 gene in the FHH/EurMcwi embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2018-10-18) Muc1em1Mcwi 13800827 2 181399482 181403640 1 - by flanking markers 2 207957206 207962396 1 - by flanking markers 2 188543137 188547874 1 - by flanking markers 2 174635559 174640738 1 - by flanking markers RRID:RGD_13800825 13800838 FHH-Mybphlem1Mcwi CRISPR/Cas9 system was used to introduce a 2-bp deletion in exon 1 of rat Mybphl gene in the FHH/EurMcwi embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Mybphlem1Mcwi 13800841 2 203934530 203948031 1 - by flanking markers 2 230628901 230643002 1 - by flanking markers 2 211158902 211173036 1 - by flanking markers 2 196005297 196018826 1 - by flanking markers RRID:RGD_13800838 13800845 FHH-Mybphlem2Mcwi CRISPR/Cas9 system was used to introduce a 1-bp insertion in exon 1 of rat Mybphl gene in the FHH/EurMcwi embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Mybphlem2Mcwi 13800846 2 203934530 203948031 1 - by flanking markers 2 230628901 230643002 1 - by flanking markers 2 211158902 211173036 1 - by flanking markers 2 196005297 196018826 1 - by flanking markers RRID:RGD_13800845 13800869 SS-P2ry2em6Mcwi CRISPR/Cas9 system was used to introduce a mutation in the P2ry2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 132-bp deletion in exon 3 in the P2ry2 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown P2ry2em6Mcwi 13800870 1 158440018 158454213 1 - by flanking markers 1 172227726 172241921 1 - by flanking markers 1 166031228 166045423 1 - by flanking markers 1 155352050 155367423 1 - by flanking markers RRID:RGD_13800869 13800871 SS-P2ry2em7Mcwi CRISPR/Cas9 system was used to introduce a mutation in the P2ry2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 115-bp deletion in exon 3 in the P2ry2 gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown P2ry2em7Mcwi 13800873 1 158440018 158454213 1 - by flanking markers 1 172227726 172241921 1 - by flanking markers 1 166031228 166045423 1 - by flanking markers 1 155352050 155367423 1 - by flanking markers RRID:RGD_13800871 13800875 SS-Prltm1(PRL)Mcwi CRISPR/Cas9 and plasmid donor containing floxed human prolactin cDNA were used to insert the human cDNA into the start coden of rat prolactin gene MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown PRL 736187 RRID:RGD_13800875 13800877 LH-Chr 17LN-C17h6orf52em2Mcwi CRISPR/Cas9 system was used to introduce a net 10-bp insertion in exon 2 of rat C17h6orf52. mutant Cryopreserved Sperm (as of 2018-10-18) C17h6orf52em2Mcwi 13800878 17 29733271 29746771 1 - by flanking markers 17 23581681 23595498 1 - by flanking markers 17 21600326 21615888 1 - by flanking markers 17 23753359 23776251 1 - by flanking markers RRID:RGD_13800877 13825143 WKY-Gja5em1Mcwi CRISPR/Cas9 system was used to introduce a 1-bp substitution and premature stop codon in exon 2 of rat Gja5 gene of WKY/NCrl rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Gja5em1Mcwi 13825144 2 191824118 191843867 1 - by flanking markers 2 218648368 218669354 1 - by flanking markers 2 199162745 199184942 1 - by flanking markers 2 184602407 184621952 1 - by flanking markers RRID:RGD_13825143 13825147 SS-Per1em3Mcwi CRISPR/Cas9 system was used to introduce a 1-bp deletion in exon 1 of Per1 gene in SS/JrHsdMcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown Per1em3Mcwi 13825148 RRID:RGD_13825147 13825196 SS-Sh2b3tm1Mcwi CRISPR/Cas9 and two ssODNs (single-stranded oligodeoxynucleotide) were used to insert loxP sites flanking multiple exons mutant Cryopreserved Sperm (as of 2018-11-21) Sh2b3tm1Mcwi 14394610 RRID:RGD_13825196 13825199 WI-Mc4rm1Hubr The Mc4r mutant rat line was generated by target-selected ENU-driven mutagenesis, and high-throughput resequencing of genomic target sequences in progeny from mutagenized rats (Wistar/Crl background) revealed an ENU-induced premature stop codon in helix 8 (K314X) of Mc4r. The heterozygous mutant rat was backcrossed to wild-type Wistar background for six generations to eliminate confounding effects from background mutations induced by ENU. Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands. Hera Biolabs, Taconic. mutant Unknown Mc4rm1Hubr 13825200 18 63390922 63392809 1 - by flanking markers 18 61799166 61801053 1 - by flanking markers 18 62612838 62614725 1 - by flanking markers 18 60419832 60421719 1 - by flanking markers RRID:RGD_13825199 13838845 SD-Ahrem2Sage ZFN constructs were designed to target exon 2 which contains the DNA binding bHLH motif of the AHR gene.This ZFN model contains a 29-bp deletion in the rat Ahr gene. mutant Unknown Ahrem2Sage 126790510 6 54205104 54240268 1 - by flanking markers 6 64589066 64624078 1 - by flanking markers 6 54963990 55001806 1 - by flanking markers 6 52234089 52271568 1 - by flanking markers RRID:RGD_13838845 14390067 WI-Slc6a4m1Hubr-/- The Slc6a4 knockout rat was generated by target-selected ENU-induced mutagenesis. An ENU-induced premature stop codon in exon 3 of the Slc6a4 gene in a female rat (Wistar from Crl) was identified.The homozygoous mutant rats were generated by incrossed between heterozygous Slc6a4 knock out rats. Hubrecht Laboratory, Utrecht, The Netherlands mutant Unknown Slc6a4m1Hubr 14390068 10 67134790 67155891 1 - by flanking markers 10 62851326 62872481 1 - by flanking markers 10 63153656 63188377 1 - by flanking markers 10 61824208 61858924 1 - by flanking markers RRID:RGD_14390067 14390069 WI-Slc6a4m1Hubr+/- The Slc6a4 knockout rat was generated by target-selected ENU-induced mutagenesis. An ENU-induced premature stop codon in exon 3 of the Slc6a4 gene in a female rat (Wistar from Crl) was identified.The heterozygoous mutant rats were used to generate homozygous Slc6a4 knock out rats. Hubrecht Laboratory, Utrecht, The Netherlands mutant Unknown Slc6a4m1Hubr 14390068 10 67134790 67155891 1 - by flanking markers 10 62851326 62872481 1 - by flanking markers 10 63153656 63188377 1 - by flanking markers 10 61824208 61858924 1 - by flanking markers RRID:RGD_14390069 14390082 SD-Tg(Fos-LacZ)Bhope The lacZ gene was inserted between NcoI and SalI sites in exon 4 of the murine Fos gene . The linearized DNA was then microinjected into fertilized rat oocytes and line 1-8 was chosen for continuation. Rats were rederived from frozen embryos in 2002 and bred onto SD background for >35 generations at NIDA IRP (Bruce Hope lab) Rat Resource and Research Center transgenic Unknown RRID:RRRC_00865 14390083 WI-Tg(Fos-LacZ)Bhope The lacZ gene was inserted between NcoI and SalI sites in exon 4 of the murine Fos gene . The linearized DNA was then microinjected into fertilized rat oocytes and line 1-8 was chosen for continuation. Initial SD rats were then bred onto Wistar background for >10 generations at NIDA IRP (Bruce Hope lab) transgenic Unknown RRID:RGD_14390083 14392784 ACI.SD-Esr1em1Soar This strain was produced by backcrossing the ZFN induced 482 deletion allele (Esr1em1Soar) in HsdHot:SD to the ACI/SegHsd background for 12 generations. ACI strain is particularly sensitive to Estrogen-induced tumorigenesis. Rat Resource and Research Center mutant Unknown (as of 2019-02-28) Esr1em1Soar 12910736 1 35523680 35759891 1 - by flanking markers 1 42534049 42935434 1 - by flanking markers 1 41192029 41594799 1 - by flanking markers 1 41106335 41499104 1 - by flanking markers RRID:RRRC_00849 14392813 SD-Cftrem1Sage+/- Cftr ZFN knockout rats possess a 16 bp deletion in exon 3 of the Cystic Fibrosis transmembrane conductance regulator (Cftr), resulting in loss of protein expression. This Cftr heterozygous rats exhibited similar bioelectric and other characteristics to wild-type. Horizon Discovery mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-03-04) Cftrem1Sage 14392814 4 43874852 44041870 1 - by flanking markers 4 42281040 42448571 1 - by flanking markers 4 42693263 42860679 1 - by flanking markers 4 46561269 46728759 1 - by flanking markers RRID:RGD_14392813 14392815 SD-Cftrem1Sage-/- CFTR ZFN knockout rats possess a 16 bp deletion in exon 3 of the Cystic Fibrosis transmembrane conductance regulator (Cftr), resulting in loss of protein expression. The homozygous mutant rats are produced by crossing the Cftr heterozygous rats. Horizon Discovery mutant Unknown (as of 2019-03-04) Cftrem1Sage 14392814 4 43874852 44041870 1 - by flanking markers 4 42281040 42448571 1 - by flanking markers 4 42693263 42860679 1 - by flanking markers 4 46561269 46728759 1 - by flanking markers RRID:RGD_14392815 14392817 SD-Cftrem1Sage+/+ CFTR ZFN knockout rats possess a 16 bp deletion in exon 3 of the Cystic Fibrosis transmembrane conductance regulator (Cftr), resulting in loss of protein expression. The homozygous mutant rats and wild-type rats are produced by crossing the Cftr heterozygous rats. mutant Unknown RRID:RGD_14392817 14394485 SD-Bace1em1Sage The mutant rats were generated by SAGE Labs using zinc-finger nuclease (ZFN) technology to create a 137-base pair deletion spanning the translation initiation start site in exon 1 of the rat Bace1 gene, corresponding to chr8:48,766,315-48,766,452 (RGSC 5.0/rn5 assembly) mutant Unknown Bace1em1Sage 13782148 8 48817824 48839681 1 - by flanking markers 8 48766005 48788272 1 - by flanking markers 8 50140092 50162388 1 - by flanking markers 8 46142060 46166268 1 - by flanking markers RRID:RGD_14394485 14394486 SD-Bace1em1Sage+/- SD-Bace1em1Sage+/Bace1em1Sage- The Bace1 (+/-) rats were generated by SAGE Labs using zinc-finger nuclease (ZFN) technology to create a 137-base pair deletion spanning the translation initiation start site in exon 1 of the rat Bace1 gene, corresponding to chr8:48,766,315-48,766,452 (RGSC 5.0/rn5 assembly) mutant Unknown Bace1em1Sage 13782148 8 48817824 48839681 1 - by flanking markers 8 48766005 48788272 1 - by flanking markers 8 50140092 50162388 1 - by flanking markers 8 46142060 46166268 1 - by flanking markers RRID:RGD_14394486 14394487 SD-Bace1em1Sage+/+ SD-Bace1em1Sage+/Bace1em1Sage+ The Bace1 (+/+) rats were generated by crossing SD-Bace1em1Sage. The mutant rats were generated by SAGE Labs using zinc-finger nuclease (ZFN) technology to create a 137-base pair deletion spanning the translation initiation start site in exon 1 of the rat Bace1 gene, corresponding to chr8:48,766,315-48,766,452 (RGSC 5.0/rn5 assembly) mutant Unknown RRID:RGD_14394487 14394488 Lew-Glp1rem2Mcwi CRISPR/Cas9 system was used to introduce a 10-bp deletion in exon 2 of the Glp1r gene in Lew/NCrl embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Glp1rem2Mcwi 14394489 20 9225881 9264184 1 - by flanking markers 20 11768479 11808416 1 - by flanking markers 20 9586075 9626228 1 - by flanking markers 20 8972004 9010241 1 - by flanking markers RRID:RGD_14394488 14394491 Lew-Glp1rem3Mcwi CRISPR/Cas9 system was used to introduce a 4-bp deletion in exon 2 of the Glp1r gene in Lew/NCrl embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Glp1rem3Mcwi 14394492 20 9225881 9264184 1 - by flanking markers 20 11768479 11808416 1 - by flanking markers 20 9586075 9626228 1 - by flanking markers 20 8972004 9010241 1 - by flanking markers RRID:RGD_14394491 14394494 SS-Kcnj2em2Mcwi CRISPR/Cas9 system was used to introduce a 28-bp deletion mutation in exon 1 of the Kcnj2 gene of SS/JrHsdMcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2019-03-22) Kcnj2em2Mcwi 14394495 10 100574985 100576268 1 - by flanking markers 10 99125234 99134077 1 - by flanking markers 10 99429337 99442520 1 - by flanking markers 10 96060849 96071401 1 - by flanking markers RRID:RGD_14394494 14394496 SS-Kcnj2em4Mcwi CRISPR/Cas9 system was used to introduce a 2-bp deletion mutation in exon 1 of the Kcnj2 gene of SS/JrHsdMcwi rat embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Kcnj2em4Mcwi 14394497 10 100574985 100576268 1 - by flanking markers 10 99125234 99134077 1 - by flanking markers 10 99429337 99442520 1 - by flanking markers 10 96060849 96071401 1 - by flanking markers RRID:RGD_14394496 14394501 SHR-Klrb1aem1Mcwi CRISPR/Cas9 system was used to introduce a 5-bp deletion in exon 2 in SHR/NCrl embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2019-03-25) Klrb1aem1Mcwi 14394503 4 165637478 165654188 1 - by flanking markers 4 227150602 227167004 1 - by flanking markers 4 161950270 161966582 1 - by flanking markers 4 161890577 161904050 1 - by flanking markers RRID:RGD_14394501 14394504 SHR-Klrb1aem2Mcwi CRISPR/Cas9 system was used to introduce a 102-bp deletion in exon 2 in SHR/NCrl embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown (as of 2019-03-25) Klrb1aem2Mcwi 14394505 4 165637478 165654188 1 - by flanking markers 4 227150602 227167004 1 - by flanking markers 4 161950270 161966582 1 - by flanking markers 4 161890577 161904050 1 - by flanking markers RRID:RGD_14394504 14394506 SS-P2ry2em5Mcwi CRISPR/Cas9 system was used to induce a mutation in the P2ry2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 27-bp deletion in exon 3. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2019-03-25) P2ry2em5Mcwi 14394507 RRID:RGD_14394506 14394508 BBDR.BBDP-(D4Mit6-D4Mit7)-Tlr4em5Mcwi CRISPR/Cas9 system was used to introduce a 5-bp deletion in exon2 in the Tlr4 gene of BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2019-03-25) Tlr4em5Mcwi 14394509 5 83564100 83577735 1 - by flanking markers 5 86690670 86704302 1 - by flanking markers 5 82587424 82601056 1 - by flanking markers 5 80145867 80159501 1 - by flanking markers RRID:RGD_14394508 14394515 LE-Grin2bem1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Grin2b gene of Crl:LE rat embryos. The resulting mutation is deletion of exon 3. Generated with support from the Simons Foundation Autism Research Initiative (SFARI); MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals; Cryopreserved Sperm (as of 2021-11-03) Autism, Developmental delay, Intellectual disability, Epilepsy (from SFARI GENE) Grin2bem1Mcwi 14394517 4 172721895 173183187 1 - by flanking markers 4 233806406 234260360 1 - by flanking markers 4 169541620 170000216 1 - by flanking markers 4 168580824 169044110 1 - by flanking markers RRID:RGD_14394515 14394518 LE-Arid1bem1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Arid1b gene of Crl:LE rat embryos. The resulting mutation is deletion of exon 4. Generated with support from the Simons Foundation Autism Research Initiative (SFARI); MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals; Cryopreserved Sperm (as of 2021-11-03) Autism, ADHD, Developmental delay, Intellectual disability, Epilepsy (from SFARI GENE) Arid1bem1Mcwi 14394519 1 40012872 40324266 1 - by flanking markers 1 47197399 47550032 1 - by flanking markers 1 45923119 46232301 1 - by flanking markers 1 45567991 45923644 1 - by flanking markers RRID:RGD_14394518 14394520 SS-Tg(CAG-loxP-stop-loxP-Rpl10a-GFP)1Mcwi SS-Tg(CAG-loxP-stop-loxP-Rpl10a-GFP)1 The Sleeping Beauty transposon system was used to introduce a Rpl10a-GFP fusion driven by a ubiquitous promoter, interupted by a floxed stop cassette MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu transgenic Unknown RRID:RGD_14394520 14394616 DA-Tph2em3Mcwi+/+ This wild type strain was produced by crossing Tph2em3Mcwi heterozygous rats and confirmed by sequencing. The Tph2em3Mcwi heterozygous mutant was created by injecting ZFNs targeting the sequence CATGGCTCCGACCCCctctacACCCCGGAACCG into DA/OlaHsd rat embryos. The resulting mutation is a 11-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Cryopreserved Sperm (as of 2021-11-03) Tph2em3Mcwi 10402820 7 54321033 54430706 1 - by flanking markers 7 58053268 58157949 1 - by flanking markers 7 58042279 58149220 1 - by flanking markers 7 50685694 50789424 1 - by flanking markers RRID:RGD_14394616 14394617 DA-Tph2em3Mcwi+/- The Tph2em3Mcwi heterozygous mutant was created by injecting ZFNs targeting the sequence CATGGCTCCGACCCCctctacACCCCGGAACCG into DA/OlaHsd rat embryos. The resulting mutation is a 11-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Unknown Tph2em3Mcwi 10402820 7 54321033 54430706 1 - by flanking markers 7 58053268 58157949 1 - by flanking markers 7 58042279 58149220 1 - by flanking markers 7 50685694 50789424 1 - by flanking markers RRID:RGD_14394617 14394618 DA-Tph2em3Mcwi-/- This homozygous mutant strain was produced by crossing Tph2em3Mcwi heterozygous rats and confirmed by sequencing. The Tph2em3Mcwi heterozygous mutant was created by injecting ZFNs targeting the sequence CATGGCTCCGACCCCctctacACCCCGGAACCG into DA/OlaHsd rat embryos. The resulting mutation is a 11-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Unknown Tph2em3Mcwi 10402820 7 54321033 54430706 1 - by flanking markers 7 58053268 58157949 1 - by flanking markers 7 58042279 58149220 1 - by flanking markers 7 50685694 50789424 1 - by flanking markers RRID:RGD_14394618 14394619 DA-Tph2em2Mcwi+/+ This wild type strain was produced by crossing Tph2em2Mcwi heterozygous rats and confirmed by sequencing. The Tph2em2Mcwi was produced by injecting ZFNs targeting the sequence CATGGCTCCGACCCCctctacACCCCGGAACCG into DA/OlaHsd rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Unknown RRID:RGD_14394619 14394620 DA-Tph2em2Mcwi+/- The Tph2em2Mcwi was produced by injecting ZFNs targeting the sequence CATGGCTCCGACCCCctctacACCCCGGAACCG into DA/OlaHsd rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 7. PhysGen Knockouts mutant Unknown Tph2em2Mcwi 10402817 7 54321033 54430706 1 - by flanking markers 7 58053268 58157949 1 - by flanking markers 7 58042279 58149220 1 - by flanking markers 7 50685694 50789424 1 - by flanking markers RRID:RGD_14394620 14394621 DA-Tph2em2Mcwi-/- The Tph2em2Mcwi was produced by injecting ZFNs targeting the sequence CATGGCTCCGACCCCctctacACCCCGGAACCG into DA/OlaHsd rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 7. This homozygous mutant strain was produced by crossing Tph2em3Mcwi heterozygous rats and confirmed by sequencing. PhysGen Knockouts mutant Unknown Tph2em2Mcwi 10402817 7 54321033 54430706 1 - by flanking markers 7 58053268 58157949 1 - by flanking markers 7 58042279 58149220 1 - by flanking markers 7 50685694 50789424 1 - by flanking markers RRID:RGD_14394621 14398460 SS-Cd40em1Uthal-/- Zinc Finger Nuclease (ZFN) was utilized to knockout rat CD40 function in the embryos of SS/JrHsd rats. The target sequence (CAGCACCGACACTGCgaactcAGTGCGTGGGGCTGCCGGG) introduced an 11 bp-deletion (CTGCGAACTCA) in the third exon of the Cd40 gene, resulted in a trucated protein. Rat Resource and Research Center mutant Unknown Cd40em1Uthal 14398461 3 156092602 156107427 1 - by flanking markers 3 167704285 167719416 1 - by flanking markers 3 161519789 161534943 1 - by flanking markers 3 153790372 153805279 1 - by flanking markers RRID:RRRC_00840 14398463 SS-Prr5em1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Prr5 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 19-bp deletion in the exon 1 of the gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2019-04-19) Prr5em1Mcwi 40818256 7 122693577 122714377 1 - by flanking markers 7 125317939 125338782 1 - by flanking markers 7 125569791 125609340 1 - by flanking markers 7 115795351 115837880 1 - by flanking markers RRID:RGD_14398463 14398465 SS-Prr5em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Prr5 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp deletion in the exon 1 of the gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2019-04-19) Prr5em2Mcwi 40818255 7 122693577 122714377 1 - by flanking markers 7 125317939 125338782 1 - by flanking markers 7 125569791 125609340 1 - by flanking markers 7 115795351 115837880 1 - by flanking markers RRID:RGD_14398465 14398479 SS-Xdhem1Mcwi CRISPR/Cas9 system was used to introduce a 7-bp deletion in exon 4 of rat Xdh gene in the SS/JrHsdMcwi embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Xdhem1Mcwi 14398480 6 21417685 21590015 1 - by flanking markers 6 34996983 35059195 1 - by flanking markers 6 25149570 25211273 1 - by flanking markers 6 21530463 21592172 1 - by flanking markers RRID:RGD_14398479 14398481 SS-Xdhem2Mcwi CRISPR/Cas9 system was used to introduce a 12-bp deletion in exon 4 of rat Xdh gene in the SS/JrHsdMcwi embryos. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Xdhem2Mcwi 14398482 6 21417685 21590015 1 - by flanking markers 6 34996983 35059195 1 - by flanking markers 6 25149570 25211273 1 - by flanking markers 6 21530463 21592172 1 - by flanking markers RRID:RGD_14398481 14398499 LE-Drd1em1(iCre)Berke The CRISPR system was used to created target insertion of iCre recombinase to the Drd1 (Drd1a) locus of the embryos of BluHsd:LE. Rat Resource and Research Center mutant Live Animals (as of 2021-02-12) Drd1em1(iCre)Berke 14398500 17 16655926 16658161 1 - by flanking markers 17 13211031 13215581 1 - by flanking markers 17 11099736 11104352 1 - by flanking markers 17 10540440 10544971 1 - by flanking markers RRID:RRRC_00856 14398734 LE-Adora2aem1(iCre)Berke The CRISPR system was used to created target insertion of iCre recombinase immediately after Adora2a gene, with P2A linker, of the embryos of BluHsd:LE. Rat Resource and Research Center mutant Live Animals (as of 2021-02-12) Adora2aem1(iCre)Berke 14398735 RRID:RRRC_00857 14398825 SD-Fahem15Dlli-/- This strain was produced by injecting Sprague Dawley embryo with CRISPR/Cas9 system targeting the exon 2 of rat Fah gene. The resulting mutation is line 15 with a frameshift deletion causing Fah null in homozygotes. None of the Fah-/- newborns survived longer than three days after birth in the absence of NTBC. Upon NTBC addition to the drinking water, the Fah-/- rats underwent normal growth and were indistinguishable from their WT littermates. East China Normal University, Shanghai, China. mutant Unknown Fahem15Dlli-/- 14398826 1 140851975 140876187 1 - by flanking markers 1 147640316 147662920 1 - by flanking markers 1 146713663 146736339 1 - by flanking markers 1 138548830 138571599 1 - by flanking markers RRID:RGD_14398825 14398828 SD-Fahem10Dlli-/- This strain was produced by injecting Sprague Dawley embryo with CRISP/Case9 system targeting the exon 2 of rat Fah gene. The resulting mutation is a 10-bp deletion in exon 2 caused premature stop in the Fah protein. None of the Fah-/- newborns survived longer than three days after birth in the absence of NTBC. Upon NTBC addition to the drinking water, the Fah-/- rats underwent normal growth and were indistinguishable from their WT littermates East China Normal University, Shanghai, China. mutant Unknown Fahem10Dlli-/- 14398829 1 140851975 140876187 1 - by flanking markers 1 147640316 147662920 1 - by flanking markers 1 146713663 146736339 1 - by flanking markers 1 138548830 138571599 1 - by flanking markers RRID:RGD_14398828 14402419 LE-Chrna5em18Pas The Zinc Finger Nuclease system was used to create184-bp deletion at the beginning of exon 5 thus created the premature stop coden. The embryos were from breeding of Long Evans from Janvier Labs (RjOrl:LE) and reimplanted to foster mother Dark Agouti (Janvier). Heterozygous rats are currently bred to generate heterozygous and homozygous. Strains were produced at Institut Pasteur (France), Departement de Neuroscience, Benoit Forget. The lines will be maintained at Charles River Laboratory France (CRLF). mutant Unknown Chrna5em18Pas 14402420 8 58538002 58566388 1 - by flanking markers 8 58143974 58172330 1 - by flanking markers 8 59561817 59590172 1 - by flanking markers 8 55369794 55398526 1 - by flanking markers RRID:RGD_14402419 14402421 LE-Chrna5em20(D398N)Pas The Zinc Finger Nuclease system was used to knock-in SNP rs16969968 in exon 5 (D398N) thus created a missense mutation. The embryos were from breeding of Long Evans from Janvier Labs (RjOrl:LE) and reimplanted to foster mother Dark Agouti (Janvier). Heterozygous rats are currently bred to generate heterozygous and homozygous. Strains were produced at Institut Pasteur (France), Departement de Neuroscience, Benoit Forget. The lines will be maintained at Charles River Laboratory France (CRLF). mutant Unknown Chrna5em20(D398N)Pas 14402422 8 58538002 58566388 1 - by flanking markers 8 58143974 58172330 1 - by flanking markers 8 59561817 59590172 1 - by flanking markers 8 55369794 55398526 1 - by flanking markers RRID:RGD_14402421 14694847 LE-Pvalbem1(flpo)Berke/Rrrc A double-stranded DNA plasmid donor was synthesized to introduce self-cleaving peptide 2A (P2A),followed by Flpo recombinase,and the V5 peptide tag (GKPIPNPLLGLDST) before the termination codon in exon 5 of rat Parvalbumin. The CRISPR/Cas9 system was used to knock in the plasmid into the targeted gene in the Crl:LE embryo. (ref:bioRxiv preprint first posted online Aug. 7, 2018; doi: http://dx.doi.org/10.1101/386474. ) Rat Resource and Research Center mutant Unknown Pvalbem1(flpo)Berke 14694849 7 116115034 116127508 1 - by flanking markers 7 119420581 119435235 1 - by flanking markers 7 119428657 119443674 1 - by flanking markers 7 109772939 109787954 1 - by flanking markers RRID:RRRC_00859 14694998 SD-Sdhbem1Ast This mutant strain was generated by injecting TALEN targeting rat Sdhb into NTac:SD embryo. The resulting mutant is a 4 bp-deletion in Sdhb. Rat Resource and Research Center mutant Unknown RRID:RRRC_00853 14694999 SD-Sdhbem2Ast This mutant strain was generated by injecting TALEN targeting rat Sdhb into NTac:SD embryo. The resulting mutant is a 6 bp-deletion in Sdhb. Rat Resource and Research Center mutant Unknown RRID:RRRC_00854 14695000 SD-Sdhbem3Ast This mutant strain was generated by injecting TALEN targeting rat Sdhb into NTac:SD embryo. The resulting mutant is a 15 bp-deletion in Sdhb. Rat Resource and Research Center mutant Unknown RRID:RRRC_00855 14695002 SD-L1camem1Jgn The CRISPR/Cas9 genome editing system was used to generate L1cam mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 4 of the rat L1cam created a 1bp-insertion (206_207insT) in exon 4. No protein expression was detected in the brain. Rat Resource and Research Center mutant Unknown L1camem1Jgn 38599015 X 159784792 159801553 1 - by flanking markers 1 152649353 152676124 1 - by flanking markers X 156901244 156928064 1 - by flanking markers X 151597270 151623776 1 - by flanking markers RRID:RRRC_00850 14695003 SD-L1camem2Jgn The CRISPR/Cas9 genome editing system was used to generate L1cam mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 4 of the rat L1cam created a 300 bp-deletion(c.205_505del) in exon 4. No protein expression was detected in the brain. Rat Resource and Research Center mutant Unknown L1camem2Jgn 14696788 X 159784792 159801553 1 - by flanking markers 1 152649353 152676124 1 - by flanking markers X 156901244 156928064 1 - by flanking markers X 151597270 151623776 1 - by flanking markers RRID:RRRC_00851 14695004 BBDR.F344-(D4Mgh24-D4Rhw6),BBDP-(D4Rhw6-D4Rhw10)/Rhw 3 Mb of F344 DNA introgressed on Chr.4 between D4Mgh24 (73.75 Mb) and D4Rhw6 (76.83 Mb), and BB diabetes prone (DP) DNA introgressed from D4Rhw6 to D4Rhw10 (the most distal marker the end of the chromosome) Rat Resource and Research Center congenic Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2019-06-27) RRID:RRRC_00458 14695026 W-Tg(Crh-cre)Msg Cre recombinase has been inserted into the genome under the control of the Crh promoter. Generated on Wistar and backcrossed to Wistar every generation. Rat Resource and Research Center transgenic Live Animals (as of 2021-02-12) RRID:RRRC_00852 14695028 SD.DA-Kcnh2tm(EGFP-Pac)1Qly This strain was made by electroporation of DAc8 embryonic stem cells with a targeting vector containing 6.3kb 5' and 2.1kb 3' homology arm. The Kcnh2 gene 7th and 8th exons are replaced with a CAG-EGFP-IRES-Pac cassette. Chimeras were formed by microinjecting into F344 blastocysts. Founder animals were mated with SD rats to produce this strain. Rat Resource and Research Center mutant Unknown RRID:RRRC_00847 14695029 SD.DA-Kcnh2tm(CAG-EGFP)1Qly This strain was made by electroporation of DAc8 embryonic stem cells with a targeting vector containing 7.5kb 5' and 1.6kb 3' homology arm. A FRT-CAG-EGFP-IRES-Pac-FRT cassette is inserted into the intron between 8th and 9th exons of Kcnh2 gene. Chimeras were formed by microinjecting into F344 blastocysts. Founder animals were mated with SD rats to produce this strain Rat Resource and Research Center mutant Unknown RRID:RRRC_00848 14695030 SD.DA-Pex1Tm(G843D-FRT-CAG-Pac-FRT)1Qly This strain was made by electroporation of DAc8 embryonic stem cells with a targeting vector containing 5.8kb 5' and 1.7kb 3' homology arms. A G843D point mutation is introduced into the Pex1 gene. The 12th and 13th exons are flanked with two loxP sites. A FRT-CAG-Pac-FRT cassette is inserted into the intron between Pex1 13th and 14th exon. This strain mimics the Peroxisomal Disorders. Heterozygote does not show any abnormalities. Rat Resource and Research Center mutant Unknown RRID:RRRC_00846 14695031 SD.DA-Il2rgTm(G843D-FRT-CAG-Pac-FRT)1Qly This strain was made by electroporation of DAc8 embryonic stem cells with a targeting vector containing 6.0kb 5' and 1.8kb 3' homology arms and a FRT-CAG-Pac-FRT cassette. The FRT-CAG-Pac-FRT cassette is inserted into the intron between Il2rg 4th and 5th exon. No genomic sequence is deleted. Chimeras were formed by microinjecting into F344 blastocysts. Founder animals were mated with SD rats to produce this strain. Rat Resource and Research Center mutant Unknown RRID:RRRC_00845 14695032 SD-Tg(CAG-loxP-mCherry-loxP-EGFP)1Qly A CAG-loxP-mCherry-loxP-EGFP cassette was injected into SD zygote to generate this line. The integration site is not determined. This transgenic line could be mated to other rat lines that express Cre/CreER for lineage tracing. Rat Resource and Research Center transgenic Unknown RRID:RRRC_00844 14695033 SD-Tg(CAG-Flpe)Qly A CAG-Flpe cassette was injected into SD zygote to generate this line. The integration site is not determined.This transgenic line could be used to mate with other rat models that contains FRT sites to remove the cassette that is flanked by those FRT sites. Rat Resource and Research Center transgenic Unknown RRID:RRRC_00843 14695034 ZUC-Leprfa.BN-(D1Rat183-D1Rat90)/Ste Congenic for distal half of Chromosome 1 from D1Rat183 to D1Rat90 from Brown Norway (BN) on the UC Davis ZUC Lepr faSte/+ strain background. The genetic backgound of the ZUC strain carries a defective leptin receptor on Chromosome 4. Rat Resource and Research Center congenic Unknown RRID:RRRC_00837 14695052 ACI-Tg(ROSA26-ALPP)Rrrc F344-Tg(ROSA26-ALPP)EpsRrrc (RGD:1566458) received in 1999 from Dr. Eric Sandgren, Univ. Wisconsin-Madison. Since 1999 bred on ACI background. Rat Resource and Research Center transgenic Cryopreserved Sperm (as of 2019-07-01) ALPP 1314395 RRID:RRRC_00817 14695053 ZDF-Cnr1em1/Rrrc ZDF-Cnr1em1 11bp deletion from genomic DNAfor the cannabinoid-1 receptor (Cnr1)using Zinc-Fingers Nucleases. Animals are resistant to the development of type-2 diabetes. Rat Resource and Research Center mutant Unknown RRID:RRRC_00800 14695054 F344-Tg(CAG-loxP-STOP-loxP-ZsGreen)551Bryd F344-Tg(CAG-loxP-STOP-loxP-ZsGreen)551 Rat Resource and Research Center transgenic Live Animals (as of 2019-07-01) RRID:RRRC_00795 14695055 MHS/Roman Milan Hypertensive Strain Inbred hypertension model linked to a mutation in Add1 gene that has been validated as one of the genes linked to hypertension in numerous human genetic studies. Inbred strain originally developed by Dr. Bianchi in Milan in 1979. Rat Resource and Research Center inbred Unknown RRID:RRRC_00794 14695058 SD-Add3em1Roman frame shift deletion in an exon 12 of Add3 gene causing a stop codon and loss of function. SD outbred background. Rat Resource and Research Center mutant Unknown RRID:RRRC_00792 14695059 BBDP/WorSunn.WAG-rnu/Sunn To develop BBDP rats congenic for the rnu mutation (nude BBDP), researchers introgressed the rnu mutation from inbred rnu/rnu WAG rats (obtained from Biomedical Research Models) using marker assisted genotyping. Rat Resource and Research Center congenic Unknown RRID:RRRC_00789 14695060 WKY-Tg(Ef1a-GFP)Tja Transgenic strain using Sleeping Beauty transposon germline transgenesis, ubiquitously expressing green fluorescent protein (GFP) under the rat elongation factor 1 alpha (Ef1a) promoter. Two integration sites located on chromosome 8:28170658 and chromosome 1:276465837, both located in intronic gene areas, Jam3 (RGD:1303248) intron 1 and Vti1a (RGD:621490) intron 6, respectively. The Jam3 intron 1 is 51bp long, and the transgene resides at 37kb from exon 1 and 13kb from exon 2. In Vti1a intron 6, 102 bp long, the transgene is located at 81.4 kb from exon 5 and 21 kb from exon 6. Rat Resource and Research Center transgenic Unknown RRID:RRRC_00780 14695061 LobRrrc:WI Lobund-Wistar Male L-W develop spontaneous tumors in the anterior and ventral prostate and the seminal vesicle @ an average of 20 months. Tumors can be induced with N-methylnitrosourea and testosterone propinate in an average of 10 months. A cell line of a prostate adenocarcinoma was also created from the strain (PAIII) and can be administer SC in L-W rats with palpable tumor in 7-14 days and metastasis to the lymph nodes and lungs in 28-30 days. Freimann Life Science Center, University of Notre Dame, Indiana , Rat Resource and Research Center outbred Unknown RRID:RRRC_00962 14695063 BN.LEW-(D10Rat258 and D10Rat51)/Ssn Severe osteopetrosis with numerous non-functioning osteoclasts. Locus on chromosome 10. Homozygotes not fertile, need to test breed to ID heterozygotes. Homozygotes have no teeth, require ground food. One of only 4 osteopetrotic mutations in rat. Genetic lesion is not yet known but mutation is inherited in an autosomal recessive manner. The candidate gene region has been localized to Chr 10 between D10Rat258 and D10Rat51. original background strain is LEW/Ssn. Rat Resource and Research Center congenic Unknown 10 11212678 13365903 1 - by flanking markers 10 10039921 13302032 1 - by flanking markers 10 11278340 13486971 1 - by flanking markers 10 11072115 13146036 1 - by flanking markers RRID:RRRC_00752 14695083 W/LnneRrrc Audiogenic Wistar rat Wistar rats maintained at the animal facility of the Ribeirao Preto School of Medicine at the University of Sao Paulo, Brazil, were tested for audiogenic seizures, using as criteria an SI and the L1 (ref. RGD:14695082). The WAR colony foundation stock was produced by mating animals displaying at least procursive behaviors in three consecutive tests, one every 4 days (two males and four females). Each couple produced two or three lit-ters, from which selected individuals displaying the highest SI and shortest L1 were mated, at adult age,with their fathers and mothers. From the second generation on, brother and sister matings were done, in a ratio of one male to two females, selected accordingto the criteria above. Rat Resource and Research Center inbred Unknown RRID:RRRC_00697 14695085 SD-Trim63em1(hiLuc)/Rrrc The use of zinc finger nuclease technology (ZFN) to knockin a luciferase reporter directly downstream of MuRF1 (Trim63) coding sequences in rats,leaving endogenous MuRF1 gene expression intact and bicistro-nically linking it to the inserted reporter through a hepatitis CIRES (HCV-IRES). The resulting knockin rat line, MuRF1-hiLUCs, has reporter characteristics that are fully reflective ofendogenous MuRF1 gene expression, can be used as a universalbiomarker of skeletal muscle atrophyin vivo, and has abioluminescent readout compatible with whole animal imagingmodalities. Rat Resource and Research Center mutant Unknown Trim63em1(hiLuc) 14696789 5 153059573 153073907 1 - by flanking markers 5 156292566 156306092 1 - by flanking markers 5 152533362 152547138 1 - by flanking markers 5 146533492 146547332 1 - by flanking markers RRID:RRRC_00731 14695086 Zuc/VcJw Zucker fatty The original background strain derived from Sherman and Merck stock M rats (13 M strain). Obese animals produced by crossing homozygous obese males to heterozygous lean females. Rat Resource and Research Center inbred Unknown RRID:RRRC_00740 14695088 WMS/SimfBR Munich Wistar Received from Munich, Germany via the V.A. San Francisco as line bred stock. Caesarean rederived when pedigreed brother x sister matings began. Selected for surface glomeruli and prominent elongated nephrons at the 6th, 12th and 18th .This strain also possess elongated nephrons. Unlike other Wistar strains with surface glomeruli, these animals do not become proteinuric as they age, which allows for the study of long term, chronic models. Age related proteinuria and spontaneous renal disease could interfere with experimentally-induced conditions. Rat Resource and Research Center inbred Cryopreserved Embryo (as of 2019-07-03) RRID:RRRC_00832 14695547 LEW-Tg(HLA-B*2705,B2M)33-3Trg This strain was made by pronuclear injection into LEW/Crl embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene and the human beta-2-microglobulin gene. The strain carries 55 copies of HLA-B*2705 and 29 copies of human beta-2-microglobulin gene. The transgenic strain was transferred from Dr. Joel Taurog, University of Texas Southwestern Medical School in Dallas to the Rat Resource and Research Center . Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2019-07-08) B2M|HLA-B 735892|1352836 RRID:RRRC_00624 14695548 LEW-Tg(HLA-B*2705,B2M)21-4HTrg This strain was made by pronuclear injection into LEW/Crl embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene and the human beta-2-microglobulin gene. The strain carries 150 copies of HLA-B*2705 and 90 copies of human beta-2-microglobulin gene. The transgenic strain was transferred from Dr. Joel Taurog, University of Texas Southwestern Medical School in Dallas to the Rat Resource and Research Center . Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2019-07-08) B2M|HLA-B 735892|1352836 RRID:RRRC_00622 14696715 SD-Htr7em1Msu CRISPR/Cas9 system was used to generate this mutant; this induced an 11 bp deletion in exon 1 and a 4 bp deletion in exon 2 of the Htr7 gene. Transgenic and Genome Editing Facility, and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan mutant Unknown Htr7em1Msu 14696716 1 240136279 240260620 1 - by flanking markers 1 261759122 261879914 1 - by flanking markers 1 254547964 254671811 1 - by flanking markers 1 233636442 233761063 1 - by flanking markers RRID:RGD_14696715 14696719 F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi+/+ These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Trpc4 gene. The heterozygotes were intercrossed to produce the wild type mutant. PhysGen, Transposagen, Rat Resource and Research Center mutant Unknown RRID:RRRC_00344 14696720 F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi-/- These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Trpc4 gene. The heterozygotes were intercrossed to produce the homozygous mutant. PhysGen, Transposagen, Rat Resource and Research Center mutant Unknown RRID:RRRC_00344 14696721 F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi-/+ These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169). This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Trpc4 gene. The heterozygotes were intercrossed to produce the heterozygous mutant. PhysGen, Transposagen, Rat Resource and Research Center mutant Unknown RRID:RRRC_00344 14696722 SD-Cyp3a23/3a1em1Myliu,Cyp3a2em1Myliu This rat strain is a double knock out for Cyp3a23/3a1 and Cyp3a2 created by using CRISPR/Cas9 targeting exons of Cyp3a23/3a1 and Cyp3a2. This strain carries a 22-bp deletion of Cyp3a23/3a1 and a 10-bp deletion of Cyp3a2 on Sprague Dawley background. East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences. Shanghai, China mutant Unknown Cyp3a23-3a1em1Myliu|Cyp3a2em1Myliu 14696724|14696725 12;12 9567120;9517016 9595974;9541000 1 - by flanking markers;1 - by flanking markers 12;12 13145742;13719927 13174596;13740743 1 - by flanking markers;1 - by flanking markers 12;12 11053888;11641500 11082742;11677818 1 - by flanking markers;1 - by flanking markers 12;12 9207986;9256159 9230038;9285020 1 - by flanking markers;1 - by flanking markers RRID:RGD_14696722 14700890 SD-Tg(Cx3cr1-cre/ERT2)3Ottc This strain was generated by microinjection of Sprague-Dawley embyos with a BAC DNA containing the Cx3cr1-cre/ERT2 transgene which is composed of cre/ERT2 recombinase gene driven by the rat genomic Cx3cr1promoter. Rat Resource & Research Center transgenic Live Animals (as of 2021-02-12) RRID:RRRC_00862 14975242 ACI.FHH-(rs105487995-rs105373896)/Mcwi This congenic line was produced by backcrossing ACI.FHH-[D1Rat74-D1Rat90] (also named Rf-1A, RGD:5143940) congenic rats to ACI rats to initiate the generation of Rf-1 congenic sublines. Offspring that had inherited a desirable recombination within the Rf-1 region were selected. These selected offspring were backcrossed and intercrossed to produce homozygous congenic sublines used for phenotyping. Medical College of Wisconsin congenic Unknown RRID:RGD_14975242 14975243 ACI.FHH-(rs105487995-rs106411696)/Mcwi This congenic line was produced by backcrossing ACI.FHH-[D1Rat74-D1Rat90] (also named Rf-1A, RGD:5143940) congenic rats to ACI rats to initiate the generation of Rf-1 congenic sublines. Offspring that had inherited a desirable recombination within the Rf-1 region were selected. These selected offspring were backcrossed and intercrossed to produce homozygous congenic sublines used for phenotyping. Medical College of Wisconsin congenic Unknown RRID:RGD_14975243 14975244 ACI.FHH-(rgdv393055223-rs107095981)/Mcwi This congenic line was produced by backcrossing ACI.FHH-[D1Rat74-D1Rat90] ((also named Rf-1A, RGD:5143940) congenic rats to ACI rats to initiate the generation of Rf-1 congenic sublines. Offspring that had inherited a desirable recombination within the Rf-1 region were selected. These selected offspring were backcrossed and intercrossed to produce homozygous congenic sublines used for phenotyping. Medical College of Wisconsin congenic Unknown RRID:RGD_14975244 14975245 ACI.FHH-(rgdv393055223-rs198922144)/Mcwi This congenic line was produced by backcrossing ACI.FHH-[D1Rat74-D1Rat90] (also named Rf-1A, RGD:5143940) congenic rats to ACI rats to initiate the generation of Rf-1 congenic sublines. Offspring that had inherited a desirable recombination within the Rf-1 region were selected. These selected offspring were backcrossed and intercrossed to produce homozygous congenic sublines used for phenotyping. Medical College of Wisconsin congenic Unknown RRID:RGD_14975245 14975246 ACI.FHH-(rgdv393055223-rs198076037)/Mcwi This congenic line was produced by backcrossing ACI.FHH-[D1Rat74-D1Rat90] (also named Rf-1A, RGD:5143940) congenic rats to ACI rats to initiate the generation of Rf-1 congenic sublines. Offspring that had inherited a desirable recombination within the Rf-1 region were selected. These selected offspring were backcrossed and intercrossed to produce homozygous congenic sublines used for phenotyping. Medical College of Wisconsin congenic Unknown RRID:RGD_14975246 14975247 ACI.FHH-(rs105373896-rgdv253272372)/Mcwi This congenic line was produced by backcrossing ACI.FHH-[D1Rat74-D1Rat90] (also named Rf-1A, RGD:5143940) congenic rats to ACI rats to initiate the generation of Rf-1 congenic sublines. Offspring that had inherited a desirable recombination within the Rf-1 region were selected. These selected offspring were backcrossed and intercrossed to produce homozygous congenic sublines used for phenotyping. Medical College of Wisconsin congenic Unknown RRID:RGD_14975247 14975248 ACI.FHH-(rs198076037-rs105278863)/Mcwi This congenic line was produced by backcrossing ACI.FHH-[D1Rat74-D1Rat90] (also named Rf-1A, RGD:5143940) congenic rats to ACI rats to initiate the generation of Rf-1 congenic sublines. Offspring that had inherited a desirable recombination within the Rf-1 region were selected. These selected offspring were backcrossed and intercrossed to produce homozygous congenic sublines used for phenotyping. Medical College of Wisconsin congenic Unknown RRID:RGD_14975248 14975305 F344-Bmpr2em1Sage+/- These ZFN mutant rats were produced by injecting zinc finger nuclease targeting rat Bmpr2 into F344 embryos. The zinc-finger nuclease mediated genome editing system created a deletion of 527 bp across intron and exon1 boundary. The strains of both sexes were confirmed Bmpr2 haplodeficiency. VA Palo Alto Health Care System, Stanford University School of Medicine mutant Unknown Bmpr2em1Sage 14981587 9 58327587 58436057 1 - by flanking markers 9 66371542 66486121 1 - by flanking markers 9 66568074 66683019 1 - by flanking markers 9 61192718 61307280 1 - by flanking markers RRID:RGD_14975305 14981588 F344-Bmpr2em2Sage+/- These ZFN mutant rats were produced by injecting zinc finger nuclease targeting rat Bmpr2 into F344 embryos. The zinc-finger nuclease mediated genome editing system created a deletion of 16 bp in exon1. The strains of both sexes were confirmed Bmpr2 haplodeficiency. VA Palo Alto Health Care System, Stanford University School of Medicine mutant Unknown Bmpr2em2Sage 14981589 9 58327587 58436057 1 - by flanking markers 9 66371542 66486121 1 - by flanking markers 9 66568074 66683019 1 - by flanking markers 9 61192718 61307280 1 - by flanking markers RRID:RGD_14981588 14981597 SD-Tg(SOD1*G93A)26DwcTac SD rats were microinjected with a linear 12 kb EcoRI-BamH1 fragment containing the coding sequence and promoter region of human SOD1 gene with G93A mutation. Originally created by John Kulik at Wyeth. Transgenic Model of SOD1 mediated Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's Disease). Came to Taconic in April 2002 for David Howland at Wyeth for distribution as an Emerging Model. Joint collaboration between Wyeth and The ALS Association. TACONIC transgenic Unknown SOD1 730855 RRID:RGD_14981597 14985210 LE-Cyfip1em1Sage+/- The bioinformatics software (Horizon Discovery, St. Louis, USA) was used to design a short guide RNA (sgRNA) targeting a Protospacer Adjacent Motif (PAM) sequence within exon 7 of the rat Cyfip1gene (GGCAGATCCACAATCCATCCagg) on chromosome 1 (first 21 of 32 exons, Refseq: NC_005100.4, NM_001107517.1).sgRNA-Cas9 was performed by nucleofecting the sgRNA-Cas9 into rat C6 glial cells. Genomic DNA (gDNA) PCR products were subsequently generated from nucleofected C6 cells using primers flanking the sgRNA site (FOR: GCCAAAGCTTCCCCTAAAGT; REV: TGGGCGTCAAGTACATTCTG; 497bp amplicon). Embryos were collected from donor female Long Evans rats and injected with the validated sgRNA-Cas9. Then implanted into synchronized pseudopregnant Long Evans recipient female This mutant carries 4bp out of frame heterozygous deletion in exon 7 of the Cyfip1, resulting bioinformatics prediction of an early stop codon in exon 8. mutant Unknown Cyfip1em1Sage 14985211 1 107245993 107334337 1 - by flanking markers 1 115265128 115353515 1 - by flanking markers 1 114258773 114347138 1 - by flanking markers 1 106710924 106799393 1 - by flanking markers RRID:RGD_14985210 14995941 Wpk Wistar polycystic kidney rat The wpk mutation was first recognized in 1994 in a colony of outbred Wistar rats at Utrecht University (Utrecht, The Netherlands). In 1996, a breeding pair of test-proven heterozygotes were transferred to the University of Rotterdam (Rotterdam, The Netherlands), and a new subcolony was initiated. This colony has been maintained by brother-sister matings for more than five generations. Individuals heterozygous for the mutant allele were identified in each generation by test-crossing phenotypically normal offspring from known heterozygotes. A single C to T substitution in exon 12 was identified as the mutated allele in the Wpk rat. This mutation converts a proline to a leucine in the protein products(P394L). This mutation was not present in the parental Wistar strain. mutant Unknown Tmem67wpk 14995943 5 26324625 26377531 1 - by flanking markers 5 30371964 30424943 1 - by flanking markers 5 25666138 25721056 1 - by flanking markers 5 25536458 25589378 1 - by flanking markers RRID:RGD_14995941 15017093 Wpk +/- Wpk heterozygous rat The wpk mutation was first recognized in 1994 in a colony of outbred Wistar rats at Utrecht University (Utrecht, The Netherlands). In 1996, a breeding pair of test-proven heterozygotes were transferred to the University of Rotterdam (Rotterdam, The Netherlands), and a new subcolony was initiated. This colony has been maintained by brother-sister matings for more than five generations. Individuals heterozygous for the mutant allele were identified in each generation by test-crossing phenotypically normal offspring from known heterozygotes. A single C to T substitution in exon 12 was identified as the mutated allele in the Wpk rat. This mutation converts a proline to a leucine in the protein products(P394L). mutant Unknown Tmem67wpk 14995943 5 26324625 26377531 1 - by flanking markers 5 30371964 30424943 1 - by flanking markers 5 25666138 25721056 1 - by flanking markers 5 25536458 25589378 1 - by flanking markers RRID:RGD_15017093 15017094 Wpk -/- Wpk homozygous rat The wpk mutation was first recognized in 1994 in a colony of outbred Wistar rats at Utrecht University (Utrecht, The Netherlands). In 1996, a breeding pair of test-proven heterozygotes were transferred to the University of Rotterdam (Rotterdam, The Netherlands), and a new subcolony was initiated. This colony has been maintained by brother-sister matings for more than five generations. Individuals heterozygous for the mutant allele were identified in each generation by test-crossing phenotypically normal offspring from known heterozygotes. A single C to T substitution in exon 12 was identified as the mutated allele in the Wpk rat. This mutation converts a proline to a leucine in the protein products(P394L). mutant Unknown Tmem67wpk 14995943 5 26324625 26377531 1 - by flanking markers 5 30371964 30424943 1 - by flanking markers 5 25666138 25721056 1 - by flanking markers 5 25536458 25589378 1 - by flanking markers RRID:RGD_15017094 15036806 WKAH/Tj Wistar-King A, WKA WKAH/Tj inbred rats were bred in the Institute for Animal Experimentation, the University of Tokushima School of Medicine, under specific pathogen free conditions. inbred Unknown (as of 2019-11-18) RRID:RGD_15036806 15045605 SD-Tg(Prnp-LacZ/EGFP)12084 This transgenic strain line 12084 carries the dual-reporter LacZ/EGFP (enhanced green fluorescent protein) cloned into the rat Prnp vector (raPrnp) and the expression of transgenes were driven by rat Prnp promoter. transgenic Unknown RRID:RGD_15045605 15045606 SD-Tg(Prnp-LacZ/EGFP)12085 This transgenic strain line Tg12085 carries the dual-reporter LacZ/EGFP (enhanced green fluorescent protein) cloned into the rat Prnp vector (raPrnp) and the expression of transgenes were driven by rat Prnp promoter. transgenic Unknown RRID:RGD_15045606 15045607 SD-Tg(Prnp-Prnp)2919 This transgenic strain line Tg2919 carries the open reading frame of rat Prnp (prion protein) cloned into the rat Prnp vector (raPrnp) and the expression of transgene were driven by rat Prnp promoter. transgenic Unknown RRID:RGD_15045607 15045608 SD-Tg(Prnp-Prnp)2922 This transgenic strain line Tg2922 carries the open reading frame of rat Prnp (prion protein) cloned into the rat Prnp vector (raPrnp) and the expression of transgene were driven by rat Prnp promoter. transgenic Unknown RRID:RGD_15045608 15090817 WI-Ahrem1Hyama+/- Heterozygous rats carrying a defective exon 2 in rat Ahr gene was created by injecting TALEN mRNA containing 5'-TTCTAAACGACACAGAGACCGGCTGAACACAGAGTTAGACCGCCTGGCTA-3' to embryos of JclKud:WI. mutant Unknown Ahrem1Hyama 15090818 RRID:RGD_15090817 15090819 WI-Ahrem1Hyama-/- The homozygous rats carrying 2 defective Ahr genes. The deletion of part of exon 2 in rat Ahr gene was created by injecting TALEN mRNA containing 5'-TTCTAAACGACACAGAGACCGGCTGAACACAGAGTTAGACCGCCTGGCTA-3' to embryos of JclKud:WI. mutant Unknown Ahrem1Hyama 15090818 RRID:RGD_15090819 18182944 SS-Vwfem2Mcwi-/- CRISPR/Cas9 mediated gene editing was used to delete a 130,954bp region of the VWF gene in DahlSS/Mcw (SS/JrHsdMcwi ) rat embryos MCW Gene Editing Rat Resource Center, through Versiti Blood Research Institute; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals (as of 2020-01-14) Bleeding Disorders Vwfem2Mcwi 18182945 4 161723415 161854766 1 - by flanking markers 4 225098521 225229257 1 - by flanking markers 4 158085059 158219525 1 - by flanking markers 4 158360152 158491539 1 - by flanking markers RRID:RGD_18182944 18182946 SS-Vwfem3Mcwi-/- CRISPR/Cas9 mediated gene editing was used to delete a 130,921bp region of the VWF gene in DahlSS/Mcw (SS/JrHsdMcwi ) rat embryos MCW Gene Editing Rat Resource Center, through Versiti Blood Research Institute; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2020-01-14) Bleeding Disorders Vwfem3Mcwi 18182947 4 161723415 161854766 1 - by flanking markers 4 225098521 225229257 1 - by flanking markers 4 158085059 158219525 1 - by flanking markers 4 158360152 158491539 1 - by flanking markers RRID:RGD_18182946 18337282 Iar: LE Long-Evans Rats This strain was established by Dr. Long and Dr. Evans in 1915. This traces its roots to Monash University to Tohoku University in 1984; to Institute for Animal Reproduction through acquisition in 1996. Institute for Animal Reproduction outbred Unknown Ophthalmology, Behavior RRID:RGD_18337282 19165133 F344;SD-C3em1Linf This mutant strain was created by CRISPR/Cas9 genome editing system. The mutant carried insertion of a premature termination codon in exon 2 and was predicted to result in loss of protein expression due to non-sense mediated decay of mRNA. The heterozygous knock out rats (F344/Sprague Dawley mixed background) were bred to each other, and the pups were genotyped to identify the WT and C3 homozygous knock out littermates. The animal facility of Lerner Research Institute, Cleveland Clinic mutant Unknown C3em1Linf 19165134 9 8728465 8754412 1 - by flanking markers 9 9721137 9747084 1 - by flanking markers 9 2087437 2114366 1 - by flanking markers RRID:RGD_19165133 19259464 SHR-Camk2n1em1Tja-/- SHR-Camk2n1em1Tja-/Camk2n1em1Tja- SHR-Camk2n1-/- knockout rats were generated on an SHR/NCrl background by microinjecting zinc-finger nuclease (ZFN) mRNA (Sigma), targeted to exon 1 of Camk2n1, into one-cell stage SHR/NCrl embryos that were implanted into pseudopregnant rats. Heterozygous progeny, from a founder harboring a 38bp deletion in Camk2n1, were intercrossed to generate homozygous knockout rats. mutant Unknown Camk2n1em1Tja 19259465 5 157235534 157237314 1 - by flanking markers 5 160625616 160627396 1 - by flanking markers 5 156876706 156878486 1 - by flanking markers 5 150674819 150676600 1 - by flanking markers RRID:RGD_19259464 21079475 SD-Leprem4Lizh The Lepr knockout rats were generated by CRISPR/Cas9. Two pairs of synthesized oligonucleotides for gRNA targeting on the exon 4 of Lepr, TAGGCAAATCATCTATAACTTC and AAACGAAGTTATAGATGATTTG; TAGGCTGAAAGCTGTCTTTCAG and AAACCTGAAAGACAGCTTTCAG were microinjected into Sprague Dawley (originally from Charles River) zygotes. The rat was genotyped by PCR with the primers, 5-prime-CTTGTGTCCAGAGCCTTCCTATAAC and 5-prime-ATTCCCCATGTTGTCTAGTAGTGATC. For genotyping, a 662-bp fragment of WT and a 368-bp fragment of the Lepr knockout gene were amplified with PCR. Founder 2 was chosen to establish a colony (designated as Lepr-/-), which carried a 298-bp deletion from No. 90043 bp to 90341 bp in the Lepr genome DNA sequence (NC_005104.4) and a 4-bp insertion and resulted in a termination codon TGA, deleting 997 amino acid of LEPR. Western blot analysis of total protein from liver tissue of the Lepr-/- rats confirmed the absence of LEPR. Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, China mutant Unknown RRID:RGD_21079475 21083604 SD-ROSA26 em1(LTR-nLuc)Ottc The CRISPR/Case9 knock-in rats have cre recombinase-dependent expression of nanoluciferase under the control of HIV LTR promoter inserted to the rat ROSA26 locus. Optogenetics and Transgenic Technology Core mutant Unknown RRID:RGD_21083604 21409748 DA/Mmab Dark Agouti Dark Agouti rats which were bred and housed at the Military Medical Academy in Belgrade, Serbia Military Medical Academy, Serbia inbred Unknown RRID:RGD_21409748 21409752 DA/Ibiss Dark Agouti Dark agouti rats were bred and housed at Institute for biological research Sinisa Stankovic, Belgrade, Serbia inbred Unknown RRID:RGD_21409752 25314294 MWF/Ztm Munich Wistar Fromter Fromter selected from outbred Munich-Wistar rats for large numbers of superficial glomeruli. inbred Unknown RRID:RGD_25314294 25330087 LE-Cntnap2em1Mcwi The rat strain was produced by injecting CRISPR/Cas9 targeting rat Cntnap2 into Crl:LE embryos. The result is a 1-bp deletion in exon 6 of the gene. Generated with support from the Simons Foundation Autism Research Initiative (SFARI); MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown Autism, ADHD, Developmental delay, Intellectual disability, Epilepsy, Bipolar disorder (from SFARI GENE) Cntnap2em1Mcwi 25330101 RRID:RGD_25330087 25330088 LE-Chd8em1Mcwi The rat strain was produced by injecting the CRISPR/Cas9 system targeting rat Chd8 gene of Crl:LE embryos. The result is a 5-bp deletion in exon 3 of rat Chd8 gene. Generated with support from the Simons Foundation Autism Research Initiative (SFARI); MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals; Cryopreserved Sperm (as of 2021-11-03) Autism, ADHD, Developmental delay, Intellectual disability, Epilepsy, Schizophrenia (from SFARI GENE) Chd8em1Mcwi 25330100 15 27642767 27704443 1 - by flanking markers 15 32423198 32482762 1 - by flanking markers 15 28612932 28672574 1 - by flanking markers 15 24905789 24965461 1 - by flanking markers RRID:RGD_25330088 25330089 LE-Nrxn1em1Mcwi The rat strain was produced by injecting CRISPR/Cas9 targeting rat Nrxn1 into Crl:LE embryos. The result is a 4-bp deletion in exon 1. Generated with support from the Simons Foundation Autism Research Initiative (SFARI ); MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown Autism, ADHD, Developmental delay, Intellectual disability, Epilepsy, Schizophrenia, Bipolar disorder (from SFARI GENE) RRID:RGD_25330089 25330091 SS-Rictorem4Mcwi CRISPR/Cas9 system was used to introduce a 11-bp deletion in exon 19 of rat Rictor gene. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Rictorem4Mcwi 40818254 2 55982784 56071528 1 - by flanking markers 2 75754848 75846705 1 - by flanking markers 2 56013898 56105818 1 - by flanking markers 2 55811877 55903893 1 - by flanking markers RRID:RGD_25330091 25330093 SD-Mir146bem1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Crl:SD rat embryos. The resulting mutation is a 7-bp deletion in Mir146b. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown Mir146bem1Mcwi 152600899 1 251558047 251558134 1 - by flanking markers 1 273520429 273520516 1 - by flanking markers 1 266089488 266089575 1 - by flanking markers 1 245203438 245203525 1 - by flanking markers RRID:RGD_25330093 25394526 LE-Dyrk1aem3Mcwi The rat strain was produced by injecting CRISPR/Cas9 targeting rat Dyrk1a into Crl:LE embryos. The result is a 5-bp deletion in exon 3 of the gene. Generated with support from the Simons Foundation Autism Research Initiative (SFARI); MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown Developmental delay, Intellectual disability, Epilepsy (from SFARI GENE) RRID:RGD_25394526 25394528 SD-Ephx2em2Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Crl:SD rat embryos. The resulting mutation is a a 23-bp deletion in exon 3. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2021-11-03) Ephx2em2Mcwi 25394529 15 45497660 45556101 1 - by flanking markers 15 48799823 48836848 1 - by flanking markers 15 42757241 42794211 1 - by flanking markers 15 40289901 40327632 1 - by flanking markers RRID:RGD_25394528 25394530 LE-Scn2aem1Mcwi The rat strain was produced by injecting CRISPR/Cas9 targeting rat Scn2a into Crl:LE embryos. The mutant allele was produced by injecting CRISPR/Cas9 targeting rat Scn2a into Crl:LE embryos. The resulting mutation is net 4-bp deletion in exon 5 comprising a 10-bp deletion (shown in lower case: CTACGGGATccctggaattGGTTGGATTTCACAGTCATT ) and a 6-bp insertion (TTCACT). MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Live Animals (as of 2021-11-03) Scn2aem1Mcwi 25394531 3 47588413 47722800 1 - by flanking markers 3 58322640 58456658 1 - by flanking markers 3 51687910 51822008 1 - by flanking markers 3 50302781 50437504 1 - by flanking markers RRID:RGD_25394530 25824850 NHla:SD The colony history began with a colony of rats established by Robert Dawley around 1925. SD rats are often referred to as "Sprague-Dawley" Mr. Dawley used both his name and the maiden name, "Sprague", of his wife to create the name of the stock. The colony then went to Sprague Dawley, Inc. in 1945. NIH began a closed colony with animals obtained from Sprague Dawley, Inc. Hilltop Lab Animals, Inc. received animals from NIH in 1984. Through cesarean rederivation, the animals were fostered onto gnotobiotic rats in isolation. Descendants of these animals then became the colonies currently available. All colony histories contain some possibility of inaccuracy. This information is provided to the best of Hilltop's knowledge. Hilltop Lab Animals, Inc. (http://www.hilltoplabs.com/public/sd.html) Hilltop Lab Animals, Inc. outbred Unknown RRID:RGD_25824850 27095885 SS.BN-(D13Hmgc41-D13Rat101)-Renem2Mcwi This strain was produced by injecting ZFNs targeting the sequence acccttcatgctggccaagtttgacggggttctgggcatg into SS.BN(D13Hmgc41-D13Rat101)/Mcwi rat embryos. The resulting mutation is a net 4-bp frameshift deletion in exon 5. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown Renem2Mcwi 27095886 RRID:RGD_27095885 30309956 SS.BN-(D13Hmgc41-D13Rat101)/Mcwi These were generated by crossing SS/JrHsdMcwi with SS-Chr 13BN/Mcwi, rats from F1 were intercrossed and genotyped to get the congenic strain. Medical College of Wisconsin, Milwaukee, Wisconsin congenic Unknown 13 45282442 49428577 1 - by flanking markers 13 54236862 58314767 1 - by flanking markers 13 49168131 53264877 1 - by flanking markers 13 43830075 47841255 1 - by flanking markers RRID:RGD_30309956 32716420 BDIX.BDIV-D6Rat132-D6Rat229/Zte The BDIX.BDIV-D6Rat132-D6Rat229/Zte congenic strain was produced by crossing BDIX (tumor-susceptible) and BDIV (tumor resistant) and then selecting for strains carrying homozygous segments of the BDIV chromosome on a BDIX background. Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany congenic Unknown 6 52753065 99750142 1 - by flanking markers 6 63175341 63175567 1 - by flanking markers 6 53553892 53554118 1 - by flanking markers 6 50818445 50818672 1 - by flanking markers RRID:RGD_32716420 35668858 LEW-Tg(HLA-B*2705m1,B2M)133-1TrgTg/0 This strain was made by pronuclear injection into Lewis embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene (human HLA-B27 gene with Serine replacing Cys67) and the human beta-2-microglobulin gene. The strain carries 12 copies of HLA-B*2705 and 4 copies of the human beta-2-microglobulin gene. transgenic Unknown RRID:RGD_35668858 35668859 W-Gnrh1tm1(cre)Aeh This model was generated using zinc finger nuclease (ZFN) method. Cre recombinase was expressed under the control of the endogenous Gnrh1 gene by inserting an internal ribosomal entry site (IRES)-Cre cassette 30bp downstream from the translational stop site of the Gnrh1 open reading frame. This was achieved by pronuclear co-injection of zinc finger nucleases (ATCCACAACATCCGAGTGtgacattGACGCTGAGATCCATGAC; cleavage site in lower case) along with a donor plasmid containing two 800bp homologous arms (HA) flanking IRES-Cre into a one-cell stage rat embryo. (1.) Allan Herbison at Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; (2.) Vincent Prevot in INSERM, Lille, France. mutant Live Animals (as of 2020-07-09) Neuroendocrinology, Neurobiology, Development RRID:RGD_35668859 35668861 LEW-Tg(HLA-B*2705,B2M)Tg/021-3Reh This strain was made by pronuclear injection into LEW/Crl embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene and the human beta-2-microglobulin gene. The strain carries 20 copies of HLA-B*2705 and 15 copies of the human beta-2-microglobulin gene. transgenic Unknown RRID:RGD_35668861 35668863 LEW-Tg(HLA-B*2705,B2M)21-3RehTg/Tg This strain was made by pronuclear injection into LEW/Crl embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene and the human beta-2-microglobulin gene. The strain carries 40 copies of HLA-B*2705 and 30 copies of human beta-2-microglobulin gene. Founder 21-3 was selected and carrier animals from this founder were mated and bred to homozygosity. transgenic Unknown RRID:RGD_35668863 36174030 SD-Hamp em1Jfcol +/- Hamp KO, Sprague-Dawley rats were generated by Transposagen Biopharmaceuticals (Lexington, KY). Four different genetically engineered rat lines, each with different sized Hamp deletions (with or without concurrent insertions), were created using TALEN technology. SD-Hamp em1Jfcol +/- (RGD: 36174030) is heterozygous carrying a 169-bp deletion between exons 2 & 3 of rat Hamp gene. Rat Resource & Research Center (RRRC) mutant Cryopreserved Sperm (as of 2020-07-28) This rat models hereditary hemochromatosis (Type 2B) in humans. Iron overload research. Hamp em1Jfcol 38455987 1 85978120 85980059 1 - by flanking markers 1 90523506 90525473 1 - by flanking markers 1 89368021 89369960 1 - by flanking markers 1 86170926 86172865 1 - by flanking markers RRID:RGD_36174030 36174220 SD-Hamp em1Jfcol -/- Hamp KO, Sprague-Dawley rats were generated by Transposagen Biopharmaceuticals (Lexington, KY). Four different genetically engineered rat lines, each with different sized Hamp deletions (with or without concurrent insertions), were created using TALEN technology. SD-Hamp em1Jfcol -/- (RGD:36174220) is homozygous carrying the 169-bp deletion between exons 2 & 3 of both rat Hamp alleles. Rat Resource & Research Center (RRRC) mutant Cryopreserved Sperm (as of 2020-07-29) This rat models hereditary hemochromatosis (Type 2B) in humans. Iron overload research. Hamp em1Jfcol 38455987 1 85978120 85980059 1 - by flanking markers 1 90523506 90525473 1 - by flanking markers 1 89368021 89369960 1 - by flanking markers 1 86170926 86172865 1 - by flanking markers RRID:RGD_36174220 36174221 SD-Hamp em2Jfcol +/- Hamp KO, Sprague-Dawley rats were generated by Transposagen Biopharmaceuticals (Lexington, KY). Four different genetically engineered rat lines, each with different sized Hamp deletions (with or without concurrent insertions), were created using TALEN technology. SD-Hamp em2Jfcol +/- (RGD:36174221) is heterozygous carrying a 230-bp deletion and a 1-bp insertion between exons 2 & 3 of the rat Hamp gene. Rat Resource & Research Center (RRRC) mutant Cryopreserved Sperm (as of 2020-07-29) This rat models hereditary hemochromatosis (Type 2B) in humans. Iron overload research. Hamp em2Jfcol 38455989 1 85978120 85980059 1 - by flanking markers 1 90523506 90525473 1 - by flanking markers 1 89368021 89369960 1 - by flanking markers 1 86170926 86172865 1 - by flanking markers RRID:RGD_36174221 36174222 SD-Hamp em2Jfcol -/- Hamp KO, Sprague-Dawley rats were generated by Transposagen Biopharmaceuticals (Lexington, KY). Four different genetically engineered rat lines, each with different sized Hamp deletions (with or without concurrent insertions), were created using TALEN technology. SD-Hamp em2Jfcol -/- (RGD:36174222) is homozygous carrying a 230-bp deletion and a 1-bp insertion between exons 2 & 3 of both rat Hamp alleles. Rat Resource & Research Center (RRRC) mutant Cryopreserved Sperm (as of 2020-07-29) This rat models hereditary hemochromatosis (Type 2B) in humans. Iron overload research. Hamp em2Jfcol 38455989 1 85978120 85980059 1 - by flanking markers 1 90523506 90525473 1 - by flanking markers 1 89368021 89369960 1 - by flanking markers 1 86170926 86172865 1 - by flanking markers RRID:RGD_36174222 36174223 SD-Hamp em3Jfcol +/- Hamp KO, Sprague-Dawley rats were generated by Transposagen Biopharmaceuticals (Lexington, KY). Four different genetically engineered rat lines, each with different sized Hamp deletions (with or without concurrent insertions), were created using TALEN technology. SD-Hamp em3Jfcol +/- (RGD:36174223) is heterozygous carrying a 20-bp deletion and a 3-bp insertion in exon 2 of the rat Hamp gene. Rat Resource & Research Center (RRRC) mutant Cryopreserved Sperm (as of 2020-07-29) This rat models hereditary hemochromatosis (Type 2B) in humans. Iron overload research. Hamp em3Jfcol 38455990 1 85978120 85980059 1 - by flanking markers 1 90523506 90525473 1 - by flanking markers 1 89368021 89369960 1 - by flanking markers 1 86170926 86172865 1 - by flanking markers RRID:RGD_36174223 36174224 SD-Hamp em3Jfcol -/- Hamp KO, Sprague-Dawley rats were generated by Transposagen Biopharmaceuticals (Lexington, KY). Four different genetically engineered rat lines, each with different sized Hamp deletions (with or without concurrent insertions), were created using TALEN technology. SD-Hamp em3Jfcol -/- (RGD:36174224) is homozygous carrying a 20-bp deletion and a 3-bp insertion in exon 2 of both rat Hamp alleles. Rat Resource & Research Center (RRRC) mutant Cryopreserved Sperm (as of 2020-07-29) This rat models hereditary hemochromatosis (Type 2B) in humans. Iron overload research. Hamp em3Jfcol 38455990 1 85978120 85980059 1 - by flanking markers 1 90523506 90525473 1 - by flanking markers 1 89368021 89369960 1 - by flanking markers 1 86170926 86172865 1 - by flanking markers RRID:RGD_36174224 36174225 SD-Hamp em4Jfcol +/- Hamp KO, Sprague-Dawley rats were generated by Transposagen Biopharmaceuticals (Lexington, KY). Four different genetically engineered rat lines, each with different sized Hamp deletions (with or without concurrent insertions), were created using TALEN technology. SD-Hamp em4Jfcol +/- (RGD:36174225) is heterozygous carrying a 15-bp deletion in exon 2 of the rat Hamp gene Rat Resource & Research Center (RRRC) mutant Cryopreserved Sperm (as of 2020-07-29) This rat models hereditary hemochromatosis (Type 2B) in humans. Iron overload research. Hamp em4Jfcol 38455991 1 85978120 85980059 1 - by flanking markers 1 90523506 90525473 1 - by flanking markers 1 89368021 89369960 1 - by flanking markers 1 86170926 86172865 1 - by flanking markers RRID:RGD_36174225 36174226 SD-Hamp em4Jfcol -/- Hamp KO, Sprague-Dawley rats were generated by Transposagen Biopharmaceuticals (Lexington, KY). Four different genetically engineered rat lines, each with different sized Hamp deletions (with or without concurrent insertions), were created using TALEN technology. SD-Hamp em4Jfcol -/- (RGD:36174226) is homozygous carrying a 15-bp deletion in exon 2 of both rat Hamp alleles Rat Resource & Research Center (RRRC) mutant Cryopreserved Sperm (as of 2020-07-29) This rat models hereditary hemochromatosis (Type 2B) in humans. Iron overload research. Hamp em4Jfcol 38455991 1 85978120 85980059 1 - by flanking markers 1 90523506 90525473 1 - by flanking markers 1 89368021 89369960 1 - by flanking markers 1 86170926 86172865 1 - by flanking markers RRID:RGD_36174226 38456008 LOU/C Bazin and Beckers from rats of presumed Wistar origin kept at the Universite Catholique de Louvain. LOU/C was selected among 28 parallel sublines for its high incidence of immunocytomas, and LOU/M for its low incidence. The two are histocomaptible (Bazin 1977, Bazin and Beckers 1978). Institut National de la Sante' et de la Recherche Medicale, Bichat-Claude Bernard, Paris, France inbred Unknown RRID:RGD_38456008 38500209 NISAG NISAG were stress-sensitive hypertensive rats that exhibited normal systolic pressure during the first weeks after birth. The development of hypertension in these rats is accompanied by increased sensitivity of the hypothalamic-pituitary-adrenocortical and sympathoadrenal systems to stress. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia inbred Unknown RRID:RGD_38500209 38501059 SD-Cpem1Ang+/+ The wild type rats were littermates of cross of heterozygotes Cp mutant rats. The mutations created by CRISPR/Cas9 contained a 54- bp deletion and a 2-bp insertion in exon1 of Cp, resulted a premature stop coden in exon 2. The sgRNAcr377 (TacGene, Paris, France) used targeted the exon 1 of Cp and had the following sequence: 59-GGAAT-TACTGAAGCAGTTT-39. mutant Unknown RRID:RGD_38501059 38501060 SD-Cpem1Ang+/- The heterozygous Cp mutant rats were created by CRISPR/Cas9. They contained a 54- bp deletion and a 2-bp insertion in exon1 of Cp, resulted a premature stop coden in exon 2. The sgRNAcr377 (TacGene, Paris, France) used targeted the exon 1 of Cp and had the following sequence: 59-GGAAT-TACTGAAGCAGTTT-39. mutant Unknown Cpem1Ang 38501062 2 105086278 105135367 1 - by flanking markers 2 124467383 124524140 1 - by flanking markers 2 104744249 104803034 1 - by flanking markers 2 102439433 102498075 1 - by flanking markers RRID:RGD_38501060 38501061 SD-Cpem1Ang-/- The homozygous Cp mutant rats are littermates of cross of heterozygotes Cp mutant rats . The mutations created by CRISPR/Cas9 contained a 54- bp deletion and a 2-bp insertion in exon1 of Cp, resulted a premature stop codon in exon 2. The sgRNAcr377 (TacGene, Paris, France) used targeted the exon 1 of Cp and had the following sequence: 59-GGAAT-TACTGAAGCAGTTT-39. mutant Unknown Cpem1Ang 38501062 2 105086278 105135367 1 - by flanking markers 2 124467383 124524140 1 - by flanking markers 2 104744249 104803034 1 - by flanking markers 2 102439433 102498075 1 - by flanking markers RRID:RGD_38501061 38501086 SD-Bmpr2em1Ang+/- BMPR2-deficient rats were generated by using zinc-finger nucleases (Sigma, St. Louis, MO). The mRNA encoding mRNA at 5 ng/μL encoding a pair of zinc-finger nucleases recognizing rat BMPR2 sequences was injected to the cytoplasm of Sprague-Dawley zygotes. A rat line with a heterozygous 140 base pairs deletion in the first exon (BMPR2Δ140Ex1/+ rats) was chosen for this study becauseit displayed an intense pulmonary vascular remodeling at 3 months of life that was absent in the wild-type littermates. mutant Unknown Bmpr2em1Ang 38501087 9 58327587 58436057 1 - by flanking markers 9 66371542 66486121 1 - by flanking markers 9 66568074 66683019 1 - by flanking markers 9 61192718 61307280 1 - by flanking markers RRID:RGD_38501086 38508891 F344-Tg(Cx3cr1-cre/ERT2)3Ottc The transgene of LE-Tg(Cx3cr1-cre)3Ottc (RGD: 13441557) was crossed onto Fischer344 background by backcrossing the hybrid to Fischer344 and select for the presence of transgene. The donor LE transgenic was generated by microinjection of LE embyos with a BAC DNA containing the Cx3cr1-cre/ERT2 transgene which is composed of cre/ERT2 recombinase gene driven by the rat genomic Cx3cr1promoter. transgenic Unknown RRID:RGD_38508891 38508893 F344.LE-ROSA26 em1(LTR-nLuc)Ottc The mutated ROSA26 locus of LE-(ROSA)26 em1(LTR-nLuc)Ottc (RGD:13208223) was crossed onto Fischer344 background by backcrossing the hybrid to Fischer344 and select for the presence of mutated locus. The LE donor is CRISPR/Case9 knock-in strain that has cre recombinase-dependent expression of nanoluciferase under the control of HIV LTR promoter inserted to the rat ROSA26 locus. mutant Unknown RRID:RGD_38508893 38543943 SD-Rag2em1Hera The Rag2 gene in rat spermatogonia stem cells (SSC, SD-WT2) was targeted by TALENs and resulted in a 27-bp in-frame deletion. The genome modified SSC was transplanted to Busulfan-treated, Dazl-deficient male Sprague Dawley rats and mated with wild type female Sprague Dawley rats 70 to 81 later. The allele was then bred to homozygosity to generate the Sprague-Dawley Rag2 (SDR)-knockout rat. mutant Unknown RRID:RGD_38543943 38548914 SD-Rag1em1Rag2em1/Mlit The Rag1, Rag2 double-knock rats were obtained by injecting the mixture of Rag1- and Rag2-targeting sgRNA into 1-cell embryo. The resulted mutations were a 1564-bp deletion in Rag1 and 85-bp deletion in Rag2. The animal facility at Tongji University (Shanghai, China). mutant Unknown RRID:RGD_38548914 38548915 SD-Il2rgem1-/y/Mlit The Il2rg knock-out rats were obtained by injecting Il2rg-targeting sgRNA into 1-cell embryos. The resulted mutation is 1-bp insertion (A) at 71169012 position. No protein was detected in the spleen of this Il2rg knock out. The animal facility at Tongji University (Shanghai, China). mutant Unknown RRID:RGD_38548915 38548916 SD-Rag1em1Rag2em1Il2rgem1-/y/Mlit The Rag1, Rag2, and Il2rg triple-knockout rats were obtained by intercrossing Rag1 and Rag2 double-knockout rat (RGD:38548914) with Il2rg knockout rat (RGD:38548915). The animal facility at Tongji University (Shanghai, China). mutant Unknown RRID:RGD_38548916 38548927 HsdCpb:WU Wistar Wu Rat The Wistar rat is selected at the Wistar Institute, Philadelphia, USA, prior to 1910. In 1932, from Wistar Institute to Glaxo Laboratory, UK. In 1933, from Glaxo to the Dutch Institution for Nutrition, Amsterdam. In 1941, the Unilever Company, Vlaardingen, the Netherlands, obtained a breeding stock from Dutch Institution for Nutrition. Thereafter, the Unilever stock was referred as the Wistar Unilever or WU rat. In 1958, transferred from Unilever to TNO Central Institute for the Breeding of Laboratory Animals. To Harlan Laboratories through acquisition in 1986. Harlan became Envigo in 2015. ENVIGO outbred Unknown RRID:RGD_38548927 38549341 RP/AEurRijHsd Muhlbock, Amsterdam, 1947, from Wistar stock. To University of Leiden in 1958. To Erasmus University, Rotterdam in 1968. To Rijswick in 1982 (Greenhouse et al 1991). To Harlan (?). inbred Unknown RRID:RGD_38549341 38549343 WKY/NIcoCrlf A substrain of WKY from Charles River France and bred at Institut Francois Magendie, Bordeaux Cedax, France. Charles River, France inbred Unknown RRID:RGD_38549343 38549351 HXB10/IpcvMcwi Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, and maintain by Medical College of Wisconsin. Medical College of Wisconsin, Milwaukee, Wisconsin recombinant_inbred Unknown RRID:RGD_38549351 38549352 SHR/OlaIpcvMcwi These are re-derived rats of SHR substrain (SHR/OlaIpcv, RGD:9586450) from Czech Academy of Sciences now maintained at Medical College of Wisconsin. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu inbred Unknown RRID:RGD_38549352 38549353 SD-Defb23em1Mlit CRISPR/Cas9 system was used to generate this mutant; sgRNA targeting exon2 of Defb23 was injected into the cytoplasm of fertilized embryos of Slc:SD. The resulting mutation is a 171-bp deletion in exon2. School of Life Science and Technology, Tong Ji University, Shanghai, China. mutant Unknown Defb23em1Mlit 38599011 3 142780126 142784338 1 - by flanking markers 3 154275191 154279834 1 - by flanking markers 3 147928201 147932413 1 - by flanking markers 3 140923474 140927686 1 - by flanking markers RRID:RGD_38549353 38549354 SD-Defb26em1Mlit CRISPR/Cas9 system was used to generate this mutant; sgRNA targeting exon2 of Defb26 was injected into the cytoplasm of fertilized embryos of Slc:SD. The resulting mutations is a 246-bp deletion in exon2. School of Life Science and Technology, Tong Ji University, Shanghai, China. mutant Unknown Defb26em1Mlit 38599012 3 142834066 142837469 1 - by flanking markers 3 154391632 154395035 1 - by flanking markers 3 147982213 147985616 1 - by flanking markers 3 140977489 140980893 1 - by flanking markers RRID:RGD_38549354 38549355 SD-Defb42em1Mlit CRISPR/Cas9 system was used to generate this mutant; sgRNA targeting exon2 of Defb42 was injected into the cytoplasm of fertilized embryos of Slc:SD. The resulting mutation is a 85 -bp deletion in exon2. School of Life Science and Technology, Tong Ji University, Shanghai, China. mutant Unknown Defb42em1Mlit 38599013 15 42247668 42254485 1 - by flanking markers 15 49925455 49932279 1 - by flanking markers 15 46159511 46166335 1 - by flanking markers 15 37234751 37241568 1 - by flanking markers RRID:RGD_38549355 38549356 SD-Defb23em2MlitDefb26em2Mlit CRISPR/Cas9 system was used to generate this double-gene knockout. The Slc:SD zygotes were injected with sgRNAs that containing 4 sgRNAs (5 ng/ml each) targeting 2 adjacent sites (target sites 1 and 2) of each of the 2 genes. The resulting mutations are 317 bp (Defb23) and 380 bp (Defb26) fragments which were deleted in the Defb23/Defb26 double-mutant strain. School of Life Science and Technology, Tong Ji University, Shanghai, China. mutant Unknown Defb23em2MlitDefb26em2Mlit 38599014 RRID:RGD_38549356 38549357 SD-Defb23em2MlitDefb26em2MlitDefb42em1Mlit CRISPR/Cas9 system was used to generate the Defb23, Defb26 double-gene knockout (RGD:38549356) and Defb42 (RGD:38549355). The triple-KO rats were generated by crossing the heterozygous Defb23/26 mutation rats with the heterozygous Defb42 mutation rats. School of Life Science and Technology, Tong Ji University, Shanghai, China. mutant Unknown Defb42em1Mlit|Defb23em2MlitDefb26em2Mlit 38599013|38599014 15 42247668 42254485 1 - by flanking markers 15 49925455 49932279 1 - by flanking markers 15 46159511 46166335 1 - by flanking markers 15 37234751 37241568 1 - by flanking markers RRID:RGD_38549357 38549372 SD-Eif2ak4em1 The sgRNA targeted the following sequence: GGACTTCCAGGATCTGCGGC CGG on the rat Eif2ak4 was injected to the one-cell stage embryos collected from female rats (Crl:SD). The strain carrying the biallelic deletion of 152 bp in the first exon of Eif2ak4. mutant Unknown Eif2ak4em1 38599016 3 104870871 104875529 1 - by flanking markers 3 116705333 116791037 1 - by flanking markers 3 110159624 110245382 1 - by flanking markers 3 105356261 105441630 1 - by flanking markers RRID:RGD_38549372 38596327 WI-Tbc1d4em1Gdcz The mutant rats were created with CRISPR/Cas9 system. A single guide RNA (sgRNA) and protospacer adjacent motif was designed targeting coding strand: 5' GCGACAAGCGCTTCCGGCTA TGG 3' with a predicted cut site 111 bp downstream of the initiation codon. Fertilized eggs, produced by mating superovulated Wistar female rats (Envigo Hsd:WI, Strain Code 001) with Wistar males, were microinjected with sgRNA and implanted to pseudopregnant rats. A founder line carrying a 20-bp substitution deletion (TGGCGACAAGCGTTCCGGC) was selected and backcrossed with wild type Wistar outbred rats (Charles River Laboratory; Wilmington, VA) to establish heterozygous (+/-) colony. No protein product was detected from knock out T homozygous mutant (-/-) . Unit for Laboratory Animal Medicine, University of Michigan. mutant Unknown Tbc1d4em1 38596330 15 85359159 85561229 1 - by flanking markers 15 89695614 89871879 1 - by flanking markers 15 85927978 86105829 1 - by flanking markers 15 78256030 78434168 1 - by flanking markers RRID:RGD_38596327 38596339 SD-Rarres2em1Msu Rat zygotes, produced by mating superovulated Sprague-Dawley females with males of the same strain [Crl:CD(SD), were microinjected with CRISPR/Cas9 reagents targeting arres2 exon2. The resulting allele lacked the splice site and the first 13 aa of exon 2. Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA. mutant Unknown Rarres2em1Msu 38596341 4 76659507 76662465 1 - by flanking markers 4 142869493 142872619 1 - by flanking markers 4 78205809 78208956 1 - by flanking markers 4 77522549 77525733 1 - by flanking markers RRID:RGD_38596339 38599146 BN-Aireem1Ang-/- The homozygous Aire mutant rats are littermates of cross of heterozygotes Aire mutant rats . The mutations created by ZFN reagents targeting to a DNA sequence 59-TGCCACCCAGACCCCCCACAAAGAGAAGAGCCCTGGAAGAG- 39 in exon 3 of the Aire gene. This mutant carries a 17-bp deletion in the nuclear localization signal sequence, causing a premature stop codon. mutant Unknown Aireem1Ang 38599148 20 10980031 10996102 1 - by flanking markers 20 13535776 13550486 1 - by flanking markers 20 11365630 11380636 1 - by flanking markers 20 10636058 10651060 1 - by flanking markers RRID:RGD_38599146 38599147 SD.BN-Aireem1Ang-/- The BN homozygous Aire mutant rats were derived from founder rats that were backcrossed in a Sprague Dawley (SD; outbred strain) background for six generations to obtain AIRE-deficient SD rats. The original founder were from BN mutants carrying the mutations created by ZFN reagents targeting to a DNA sequence 59-TGCCACCCAGACCCCCCACAAAGAGAAGAGCCCTGGAAGAG- 39 in exon 3 of the Aire gene. This mutant carriesa 17-bp deletion in the nuclear localization signal sequence, causing a premature stop codon. mutant Unknown Aireem1Ang 38599148 20 10980031 10996102 1 - by flanking markers 20 13535776 13550486 1 - by flanking markers 20 11365630 11380636 1 - by flanking markers 20 10636058 10651060 1 - by flanking markers RRID:RGD_38599147 38599152 WI-Lpin1m1Hubr The mutant rats were created using N-ethyl-N-nitrosourea (ENU) mutagenesis. A point mutation in the 5'-end splice site of intron 18 resulting in mis-splicing, a reading frameshift, and a premature stop codon was identified. As this mutation does not induce nonsense-mediated decay, it allows the production of a truncated Lipin 1 protein lacking phosphatidate phosphatase 1 activity. From the Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands, mutant Unknown Lpin1m1Hubr 38599153 6 40253664 40297195 1 - by flanking markers 6 51532422 51638090 1 - by flanking markers 6 41796214 41905149 1 - by flanking markers 6 39309198 39417034 1 - by flanking markers RRID:RGD_38599152 38599155 BN-Themism1Adej This autosomal recessive mutation occurred spontaneously in a Brown-Norway rat colony and was identified as causing marked T cell lymphopenia. The mutation was identified as a frameshift mutation caused by a four-nucleotide insertion in the Themis gene, leading to its disruption. UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Universit de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France mutant Unknown Themism1Adej 38599156 1 17032677 17226924 1 - by flanking markers 1 18308043 18532366 1 - by flanking markers 1 17152973 17378225 1 - by flanking markers 1 16433906 16623889 1 - by flanking markers RRID:RGD_38599155 38599157 F344-Depdc5em1Kyo+/- TALEN mRNAs targeting exon 2 of rat Depdc5 were microinjected into fertilized eggs of Fisher 344 (F344) rats to yield two founder mutant rats named Depdc5em1kyo (c.40_44delins17/p.Gly15*) and Depdc5em2kyo (c.39_55delinsT/p.Lys13fs*8). The genome edited fragment was identified by PCR. A 267 bp band was detected for wildtype, a 279 bp band for Depdc5em1kyo mutant and a 251 bp band for Depdc5em2kyo mutant. Depdc5 mutant homozygous pups were never observed at birth. Deletion of both alleles resulted in in utero lethality started around E14.5. National Bio Resource Project Rat in Japan mutant Unknown Depdc5em1Kyo 38599194 14 83484354 83614818 1 - by flanking markers 14 83775510 83906381 1 - by flanking markers 14 83089000 83219576 1 - by flanking markers 14 77732297 77862924 1 - by flanking markers RRID:RGD_38599157 38599158 F344-Depdc5em2Kyo+/- TALEN mRNAs targeting exon 2 of rat Depdc5 were microinjected into fertilized eggs of Fisher 344 (F344) rats to yield two founder mutant rats named Depdc5em1kyo (c.40_44delins17/p.Gly15*) and Depdc5em2kyo (c.39_55delinsT/p.Lys13fs*8). The genome edited fragment was identified by PCR. A 267 bp band was detected for wildtype, a 279 bp band for Depdc5em1kyo mutant and a 251 bp band for Depdc5em2kyo mutant. Depdc5 mutant homozygous pups were never observed at birth. Deletion of both alleles resulted in in utero lethality started around E14.5. National BioResource Project for the Rat in Japan mutant Unknown Depdc5em2Kyo 38599195 14 83484354 83614818 1 - by flanking markers 14 83775510 83906381 1 - by flanking markers 14 83089000 83219576 1 - by flanking markers 14 77732297 77862924 1 - by flanking markers RRID:RGD_38599158 38599187 SHRSP.SHR-(D1Mgh5-D1Got87)(D18Rat73-D18Rat11)/Izm A double congenic strain made by introducing a segments of chromosome 1 and 18 from SHR/Izm into SHRSP/Izm. Developed by Dr. Tohru Nabika from Shimane University. National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm (as of 2020-09-14) Hypertension and cerebral apoplexy 1;18 78134304;52290789 85828306;71692408 1 - by flanking markers;1 - by flanking markers 1;18 80946174;50804228 92291485;69942605 1 - by flanking markers;1 - by flanking markers 1;18 79689548;51609032 91156803;70803264 1 - by flanking markers;1 - by flanking markers 1;18 78430536;49999958 86030749;68414117 1 - by flanking markers;1 - by flanking markers RRID:RGD_38599187 38599188 SHRSP.SHR-(D1Rat23-D1Rat213)(D18Rat73-D18Rat11)/Izm A double congenic strain made by introducing a segments of chromosome 1 and 18 from SHR/Izm into SHRSP/Izm. Developed by Dr. Tohru Nabika from Shimane University. National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm (as of 2020-09-14) Hypertension and cerebral apoplexy 1;18 78685103;52290789 81548909;71692408 1 - by flanking markers;1 - by flanking markers 1;18 81497710;50804228 84537228;69942605 1 - by flanking markers;1 - by flanking markers 1;18 80231217;51609032 83282814;70803264 1 - by flanking markers;1 - by flanking markers 1;18 78970983;49999958 81777720;68414117 1 - by flanking markers;1 - by flanking markers RRID:RGD_38599188 38599189 F344-Rag2em1Iexas This strain was established by targeting Rag2 gene in F344/Jcl using CRISPR/Cas9 system. gRNA to Rag2: AACATAGCCTTAATTCAACCAGG (PAM: last AGG); Cas 9 mRNA transcribed from T7-NLS hCas9-pA (RDB13130) was used for the system. Gene transfer was performed by electroporation. This strain shows severe combined immunodeficiency (SCID) caused by 1-bp insertion in Rag2 gene on chromosome 3. This strain grows normally under SPF condition. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2020-09-14) immunology/Inflamation and Immunodeficient Rag2em1Iexas 38599191 3 86764810 86773438 1 - by flanking markers 3 97851318 97859615 1 - by flanking markers 3 91191837 91200134 1 - by flanking markers 3 87902373 87910227 1 - by flanking markers RRID:RGD_38599189 38599190 F344-Il2rgem1IexasRag2em1Iexas This strain was established by targeting Il2rg gene and Rag2 gene in F344/Jcl using CRISPR/Cas9 system. gRNA seq to Il2rg: CCAACCTCACTATGCACTATAGG (PAM: first CCA); gRNA to Rag2: AACATAGCCTTAATTCAACCAGG (PAM: last AGG); Cas 9 mRNA transcribed from T7-NLS hCas9-pA (RDB13130) was used for the system. Gene transfer was performed by electroporation.This strain shows severe combined immunodeficiency (SCID) caused by 5-bp deletion in Il2rg gene on X chromosome and 1-bp insertion in Rag2 gene on chromosome 3. This strain grows normally under SPF condition. The sexual maturation is a bit late. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2020-09-14) severe combined immunodeficiency Il2rgem1Iexas|Rag2em1Iexas 13464264|38599191 3;X 86764810;89342055 86773438;89345715 1 - by flanking markers;1 - by flanking markers 3;X 97851318;72017856 97859615;72021516 1 - by flanking markers;1 - by flanking markers 3;X 91191837;71165378 91200134;71169078 1 - by flanking markers;1 - by flanking markers 3;X 87902373;66395330 87910227;66399026 1 - by flanking markers;1 - by flanking markers RRID:RGD_38599190 38599197 W.F344-Lepm1Kyo This cocngenic strain was made by backcrossing F344-Lepm1Kyo(RGD: 8549776, F344/NSlc rats having an induced mutation in the Lep gene by ENU mutagenesis) to W/Kyo (RGD:1302672). National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm (as of 2020-09-14) Obesity Lepm1Kyo 12792963 4 55943837 55945938 1 - by flanking markers 4 56085079 56099209 1 - by flanking markers 4 56337695 56351818 1 - by flanking markers 4 57661127 57675262 1 - by flanking markers RRID:RGD_38599197 38599201 SHRSP.SHR-(D18Rat73-D18Rat8)/Izm A congenic strain made by introducing a segments of chromosome 18 from SHR/Izm into SHRSP/Izm. National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm (as of 2020-09-15) Hypertension and cerebral apoplexy 18 52290789 72450442 1 - by flanking markers 18 50804228 70825941 1 - by flanking markers 18 51609032 71692768 1 - by flanking markers 18 49999958 69140759 1 - by flanking markers RRID:RGD_38599201 38599202 SHRSP.SHR-(D1Rat23-D1Rat213)(D18Rat73-D18Rat52)/Izm A double congenic strain made by introducing a segments of chromosome 1 and 18 from SHR/Izm into SHRSP/Izm. National BioResource Project for the Rat in Japan, Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan. congenic Cryopreserved Sperm (as of 2020-09-15) Hypertension and cerebral apoplexy 1;18 78685103;52290789 81548909;61290878 1 - by flanking markers;1 - by flanking markers 1;18 81497710;50804228 84537228;59735418 1 - by flanking markers;1 - by flanking markers 1;18 80231217;51609032 83282814;60532087 1 - by flanking markers;1 - by flanking markers 1;18 78970983;49999958 81777720;58536311 1 - by flanking markers;1 - by flanking markers RRID:RGD_38599202 38599203 LE-Tg(Gt(ROSA26)Sor-CAG-COP4*C167A/YFP*)2Jfhy The transgenic LE line 2(Back ground strain: Iar:Long-Evans (RGD:18337282) (Kumagai-shigeyasu Co.,Ltd)) carrying Transgene: ROSA26 (mouse ROSA26 BAC: RP23 244D9), and Channel rhodopsin fast receiver (ChRFR)(COP4*C167A) (Chlamydomonas reinhardtii) fused with YFP* (Venus). Copy number: 3, In this strain, COP4*C167A, modified photosensitivity cation channel, is expressed ubiquitously in the presence of exogenous Cre protein. The ChRFR(COP4*C167A), one of the channel rhodopsin (step-function opsin, SFO), opens under blue light and is closed under yellow light. The Venus (YFP*) is tagged with channel rhodopsin. There is no differences between line 1 and 2 except for copy number. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-15) RRID:RGD_38599203 38599204 LE-Tg(Gt(ROSA26)Sor-CAG-COP4*C167A/YFP*)1Jfhy The transgenic LE line 2(Back ground strain: Iar:Long-Evans (RGD:18337282) (Kumagai-shigeyasu Co.,Ltd)) carrying Transgene: ROSA26 (mouse ROSA26 BAC: RP23 244D9), and Channel rhodopsin fast receiver (ChRFR)(COP4*C167A) (Chlamydomonas reinhardtii) fused with YFP* (Venus). Copy number: 1, In this strain, COP4*C167A, modified photosensitivity cation channel, is expressed ubiquitously in the presence of exogenous Cre protein. The ChRFR(COP4*C167A), one of the channel rhodopsin (step-function opsin, SFO), opens under blue light and is closed under yellow light. The Venus (YFP*) is tagged with channel rhodopsin. There is no differences between line 1 and 2 except for copy number. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-15) RRID:RGD_38599204 38599206 SHR-Prdx2em2Izm This strain is established at Kyoto University: By CRISPR/Cas9 system, mutation was introduced in Peroxiredoxin-2 (Prdx2) gene of SHR/Izm rat. This KO rat strain has 6-bp deletion (5'-CTCCGG-3', c.6_12del6) in the exon2 of Prdx2 gene. Target sequence is 5?-CCTCCGGCAACGCGCACATCGGA-3?(PAM sequence:CCT). National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-15) RRID:RGD_38599206 38599208 SHR-Prdx2em1Izm This strain is established at Kyoto University: By CRISPR/Cas9 system, mutation was introduced in Peroxiredoxin-2 (Prdx2) gene of SHR/Izm rat. This KO rat strain has 7-bp deletion (5'-CTCCGGC-3', c.6_13del7) in the exon2 of Prdx2 gene. Target sequence is 5?-CCTCCGGCAACGCGCACATCGGA-3?(PAM sequence:CCT). National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-15) RRID:RGD_38599208 38599241 SD;DA-Tg(Thy1-APP*)1Dspb Mutant human amyloid beta (APP*) combined Thy1 promoter which is specifically expressed in neurons, was induced to ES cells from DA strain rats, and chimera rats obtained from the ES cells. The F1 rats were backcrossed with Crl:CD (SD) strain rats and F3 rats was deposited to NBRP. The expression levels of mutant human APP mRNA are different among Lines (12>1>14>6). National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-16) dementia RRID:RGD_38599241 38599242 SD;DA-Tg(Thy1-APP*)6Dspb Mutant human amyloid beta (APP*) combined Thy1 promoter which is specifically expressed in neurons, was induced to ES cells from DA strain rats, and chimera rats obtained from the ES cells. The F1 rats were backcrossed with Crl:CD (SD) strain rats and F3 rats was deposited to NBRP. The expression levels of mutant human APP mRNA are difficult among Lines (12>1>14>6). National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-16) dementia RRID:RGD_38599242 38599243 SD;DA-Tg(Thy1-APP*)12Dspb Mutant human amyloid beta (APP*) combined Thy1 promoter which is specifically expressed in neurons, was induced to ES cells from DA strain rats, and chimera rats obtained from the ES cells. The F1 rats were backcrossed with Crl:CD (SD) strain rats and F3 rats was deposited to NBRP. The expression levels of mutant human APP mRNA are difficult among Lines (12>1>14>6). National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-16) dementia RRID:RGD_38599243 38599244 SD;DA-Tg(Thy1-APP*)14Dspb Mutant human amyloid beta (APP*) combined Thy1 promoter which is specifically expressed in neurons, was induced to ES cells from DA strain rats, and chimera rats obtained from the ES cells. The F1 rats were backcrossed with Crl:CD (SD) strain rats and F3 rats was deposited to NBRP. The expression levels of mutant human APP mRNA are difficult among Lines (12>1>14>6). National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-16) dementia RRID:RGD_38599244 38599245 LE-Tg(Tac1-cre)6-7Koba Background strain: Long-Evans rat (Iar:Long-Evans, RGD:18337282). This strain was established by injection of modified BAC (cre gene was inserted into the exon 2 of rat Tac1 gene) into Long-Evans rat's fertile eggs. This transgenic strain expresses Cre recombinase under the control of Tac1 promoter. The expression levels of Cre recombinase in LE-Tg(Tac1-cre)6-7Koba are lower than in LE-Tg(Tac1-cre)4-1Koba (RGD:38599247) National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-16) RRID:RGD_38599245 38599247 LE-Tg(Tac1-cre)4-1Koba Background strain: Long-Evans rat (Iar:Long-Evans, RGD:18337282). This strain was established by injection of modified BAC (cre gene was inserted into the exon 2 of rat Tac1 gene) into Long-Evans rat's fertile eggs.This transgenic strain expresses Cre recombinase under the control of Tac1 promoter. The expression levels of Cre recombinase in LE-Tg(Tac1-cre)4-1Koba are higher than in LE-Tg(Tac1-cre)6-7Koba (RGD:38599245). National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-16) RRID:RGD_38599247 38676250 F344-Hcn1em3Kyo TALEN (Left:ttcagＡＡＴＧＡＴＴＣＡＴＧＧＧ, Right:ＡＣＧＣＡＣＴＣＴＴＣＡＡＡＧＣＴＡ）targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 13-bp deletion in the exon4 of Hcn1 gene: as a result of frameshift mutation, stop codon is produced. Decreased expression levels of Hcn1 gene and HCN1 protein. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-16) RRID:RGD_38676250 38676251 F344-Hcn1em2Kyo TALEN (Left: ttcagAATGATTCATGGG, Right : ACGCACTCTTCAAAGCTA) targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 24-bp deletion in the exon4 of Hcn1 gene. It is predicted that 8 amino-acid deleted HCN1 protein is expressed. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-16) RRID:RGD_38676251 38676253 F344-Hcn1em1Kyo TALEN (Left: ttcagAATGATTCATGGG, Right : ACGCACTCTTCAAAGCTA) targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 7-bp deletion in the exon4 of Hcn1 gene: as a result of frameshift mutation, stop codon is produced. Decreased expression levels of Hcn1 gene and HCN1 protein. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-16) Hcn1em1Kyo 150429632 2 49525949 49939066 1 - by flanking markers 2 68473431 68874494 1 - by flanking markers 2 50099576 50499799 1 - by flanking markers 2 49495771 49899702 1 - by flanking markers RRID:RGD_38676253 38676254 F344-Ppargm1Kyo By using ENU mutagenesis followed by MuT-POWER screening of the KURMA (Kyoto University Rat Mutant Archive) samples, the depositors generated a heterozygous PPARg mutant (Ppargmkyo/+) rat with a missense mutation (G488T p.C163F in Pparg1 or G578T p.C193F for Pparg2) in Pparg. The PpargG488T homozygous rats are embryonic lethal. Heterozygous Ppargmkyo/+ rats showed reduced fat mass with adipocyte hypertrophy and insulin resistance, which were highly predictable from known actions of Pparg agonists and phenotypes of patients with the PPARG mutation. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-16) Ppargm1Kyo 127285617 4 151492220 151617331 1 - by flanking markers 4 210562928 210688585 1 - by flanking markers 4 147274055 147399383 1 - by flanking markers 4 148423102 148548471 1 - by flanking markers RRID:RGD_38676254 38676255 F344-Hcn1em4Kyo TALEN (Left: ttcagAATGATTCATGGG, Right : ACGCACTCTTCAAAGCTA) targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 18-bp deletion in the exon4 of Hcn1 gene. It is predicted that 6 amino-acid deleted HCN1 protein is expressed. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-16) RRID:RGD_38676255 38676310 RjHan:SD The outbred strain [Sprague-Dawley] was created by R. W. Dawley in 1925, from a hooded male hybrid of unknown origin and an albino female (probably Wistar), and was crossed with the female's progeny for 7 generations. Janvier Labs received from Zentralinstitut fur Versuchstierzucht (Hannover) in1982. Janvier Labs, France outbred Live Animals (as of 2020-09-17) RRID:RGD_38676310 38676445 W-Tg(Slc32a1-cre)1_4Fusa This strain was established by Bac transgenic method (construct: Kazuhiro Yamakawa, phD) supported by C.B.S.Nresource (Dr. Kazuto Kobayashi, Dr. Yuchio Yanagawa) in 2014 and maintained at Jikei University School of Medicine. Background: Crlj:WI. Transgene: VGAT (Slc32a1: mouse, Kanamycin registance gene (E. coli), Cre (P1 phage), polyA signal (SV40 virus. Mouse BAC clone: RP23-392-P11). Cre recombinase is expressed under the control of mouse Slc32a1 (VGAT) promoter. This strain is used for GABAergic neuron-specific Cre-Lox site-specific recombination system. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-17) RRID:RGD_38676445 38676446 W-Tg(Slc32a1-cre)2_5Fusa This strain was established by Bac transgenic method (construct: Kazuhiro Yamakawa, phD) supported by C.B.S.Nresource (Dr. Kazuto Kobayashi, Dr. Yuchio Yanagawa) in 2014 and maintained at Jikei University School of Medicine. Background: Crlj:WI. Transgene: VGAT (Slc32a1: mouse, Kanamycin registance gene (E. coli), Cre (P1 phage), polyA signal (SV40 virus. Mouse BAC clone: RP23-392-P11). Cre recombinase is expressed under the control of mouse Slc32a1 (VGAT) promoter. This strain is used for GABAergic neuron-specific Cre-Lox site-specific recombination system. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-17) RRID:RGD_38676446 38676447 W-Tg(Slc32a1-cre)5_9Fusa This strain was established by Bac transgenic method (construct: Kazuhiro Yamakawa, phD) supported by C.B.S.Nresource (Dr. Kazuto Kobayashi, Dr. Yuchio Yanagawa) in 2014 and maintained at Jikei University School of Medicine. Background: Crlj:WI. Transgene: VGAT (Slc32a1: mouse, Kanamycin registance gene (E. coli), Cre (P1 phage), polyA signal (SV40 virus. Mouse BAC clone: RP23-392-P11). Cre recombinase is expressed under the control of mouse Slc32a1 (VGAT) promoter. This strain is used for GABAergic neuron-specific Cre-Lox site-specific recombination system. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-17) RRID:RGD_38676447 38676448 W-Trpa1em1Kcrd This Trpa1-deleted Wistar (background: Crl:WI) strain was generated by using Zinc Finger Nuclease at Kirin Company, Limited in 2013. Exon 22-24, which form ion channel pore required for the activation in Trpa1 gene, was deleted. National BioResource Project for the Rat in Japan mutant Cryopreserved Embryo (as of 2020-09-17) Trpa1em1Kcrd 38676449 5 3531163 3584401 1 - by flanking markers 5 3764339 3818781 1 - by flanking markers 5 3783247 3836485 1 - by flanking markers 5 4379999 4433243 1 - by flanking markers RRID:RGD_38676448 38676450 F344-Phf24em2Kyo In 2013, F344/Stm female rat deleted 392b (delta392) of KIAA1045 (Phf24) was generated by Platinum TALEN methods. Although spontaneous GTCS is not observed, seizure susceptibility is increased and kindling induced by PTZ is promoted. In addition, locomotor activity is increased, disturbed behavior and spacial memory are decreased, and emotional behavior is increased due to unpleasant stimulation. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm (as of 2021-07-01) RRID:RGD_38676450 38676451 W-Phf24em11Iexas This strain was establishe by CRISPR-Cas9 system at Osaka University. Target sequence is CCATGGGGGTGTTGATGTCCAAG (CCA is PAM sequence). Back ground strain is Crlj:Wistar (WI). This strain is line No. 11 and has a 128-bp deletion in Phf24 gene. Off-target effects (214 candidate region) have not yet been examined. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-17) RRID:RGD_38676451 38676452 W-Phf24em24Iexas This strain was establishe by CRISPR-Cas9 system at Osaka University. Target sequence is CCATGGGGGTGTTGATGTCCAAG (CCA is PAM sequence). Back ground strain is Crlj:Wistar (WI). This strain is line No. 24 and has a 141-bp deletion in Phf24 gene. Off-target effects (214 candidate region) have not yet been examined. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-17) RRID:RGD_38676452 38676453 F344; W-Phf24em6(EGFP)Iexas This strain (line No. 6) was establishe by CRISPR-Cas9 system at Osaka University and EGFP sequence was knock-in in Phf24 gene. Back ground strain is Crlj:Wistar (WI). Founder rats were crossed with F344/NSlc, and this strain was maintained by crossing with F344/NSlc (F2 or F3 generation, November 2017). At the point of sperm cryopreservation, this strain is not "congenic" strain (backcross generation was <5 generations), but background is mix of Crlj:Wistar and F344/NSlc. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-17) RRID:RGD_38676453 38676459 HHR/Hat Hirosaki hairless rat Hirosaki hairless rat (HHR) is a mutant strain spontaneously derived from Sprague-Dawley rats, and its inheritance is autosomal recessive. . These mutations are autosomal recessive and are suggested to be due to deletion of the keratin gene cluster. HHR attain sexualmaturity at approximately 10 weeks of age and give birth to young but are not able to nurse them. Depart of Biochemistry and Genome Biology, Hirosaki Univer-sity School of Medicine mutant Unknown RRID:RGD_38676459 38676461 HiSER/Hat Hirosaki small-eye rat HiSER was established in 2013 as a spontaneous mutant of Sprague-Dawley rat. This mutant strain has retinal detachment and the disease is progressively exacerbated. The muation is autosomal recessive and is suggested to be due to deletion of the crystallin gene Cryba1. Depart of Biochemistry and Genome Biology, Hirosaki Univer-sity School of Medicine mutant Unknown RRID:RGD_38676461 38676463 HHSE/Hat HHSE/Hat was derived from Hirosaki hairless rat (HHR) and Hirosaki small-eye rat (HiSER), which are Sprague-Dawley rat (SDR)mutant lines. HHR was established in 1984 as a spontaneous mutant of SDR that has been inbred in Department of Biochemistry and Genome Biology Hirosaki University Graduate School of Medicine. Whole body shows hypotrichosis, abnormal differentiation of thymus, and regressed mammary gland in females. These mutations are autosomal recessive and are suggested to be due to deletion of the keratin gene cluster and the lectin-like receptor gene Ly49s3. HiSER was established in 2013 as a spontaneous mutant of Sprague-Dawley rat maintained in our course in the same way as HHR/Hat. This mutant strain has retinal detachment and the disease is progressively exacerbated. The muation is autosomal recessive and is suggested to be due to deletion of the crystallin gene Cryba1. The mutations in HHR and HiSER are on different chromosomes and do not affect each other. The mutations in HHR and HiSER are on different chromosomes and do not affect each other. National BioResource Project for the Rat in Japan ;Depart of Biochemistry and Genome Biology, Hirosaki Univer-sity School of Medicine mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2020-09-18) Cryba1Hiser 38676462 10 63758929 63765451 1 - by flanking markers 10 66458061 66480390 1 - by flanking markers 10 65160777 65167504 1 - by flanking markers 10 62608373 62614726 1 - by flanking markers RRID:RGD_38676463 38676464 WIC-Cspg4em1Kyst By CRISPR/Cas9 system, mutation was introduced in Cspg4 gene of Wistar-Imamichi rat. 7 bp deletion on Exon1. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-18) RRID:RGD_38676464 38676495 BN-Lx/CubMcwi Brown Norway with polydactyly-luxate These are re-derived rats of BN-Lx/Cub now maintained at Medical College of Wisconsin. The parent strain was derived by introgressing mutant Lx gene of the polydactylous (PD/Cub) rat onto the BN background. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu mutant Unknown (as of 2021-07-21) The Hybrid Rat Diversity Panel RRID:RGD_38676495 39128162 WIC-Cspg4em2Kyst By CRISPR/Cas9 system, mutation was introduced in Cspg4 gene of Wistar-Imamichi rat. 7 bp deletion on Exon1. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-23) RRID:RGD_39128162 39128163 WIC-Cspg4em3Kyst By CRISPR/Cas9 system, mutation was introduced in Cspg4 gene of Wistar-Imamichi rat. 2 bp insertion on Exon1. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-23) RRID:RGD_39128163 39128166 WIC-Sparcem1Kykn By CRISPR/Cas9 system, mutation was introduced in Sparc gene of Wistar-Imamichi rat. 7 bp deletion around Exon7. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-23) RRID:RGD_39128166 39128167 W-Tg(Grp-YFP*)14Hskmt This strain was generated by microinjecting YFP* (Venus): yellow fluorescent protein variant, which is inserted at downstream of Grp-promoter (4 kb) to Wistar rat zygotes. The number of inserted gene is approximately 100 copy. National BioResource Project for the Rat in Japan transgenic Live Animals; Cryopreserved Sperm (as of 2020-09-23) RRID:RGD_39128167 39128170 SHRSP-Stim1em1Izm "This strain was generated by co-introducing fertilized eggs of SHRSP/Izm with the guide RNA/Cas9 nuclease expression plasmid and ssODN, which targets the Stim1 gene, at the Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University. SHRSP/Izm strain has a nonsense mutation (c.1918C>T, p.Arg640X) in the Stim1 gene, but homologous recombination with the introduced ssODN replaces this mutation with a normal sequence. The sequence of the guide RNA target site is as follows, Stim1: 5'-GCAGGGTAGCTGAAACACAC-3' The sequence of the ssODN for homologous recombination is as follows, 5'-ATAGCCTTCTTGCCAGCCAAGTGGGGAATTCGTGTGTTTCGGCTACCCTGCAGGGCTCGGCTGTCCCCAACTGGAGATGGCCATCTCCAGTTGGGGACAGCCGAGCCCTGCAGGGTAGCCGAAACACACGAATTCCCCACTTGGCTGGCAAGAAGGCTAT-3'" National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2020-09-23) RRID:RGD_39128170 39128171 LE-Tg(Pvalb-cre)2-28Koba This strain is established by injection of modified BAC (cre gene was inserted into the exon 2 of mouse Pvalb gene) into Long-Evans rat's fertile eggs. National BioResource Project for the Rat in Japan mutant Live Animals; Cryopreserved Sperm (as of 2020-09-23) RRID:RGD_39128171 39128172 W-Tg(Slc32a1-cre)3_5Fusa This strain was established by Bac transgenic method (construct: Kazuhiro Yamakawa, phD) in 2014 and maintained at Jikei University School of Medicine. Background: Crlj:WI. Transgene: VGAT（Slc32a1: mouse, Kanamycin resistance gene（E. coli）, Cre（P1 phage), polyA signal（SV40 virus). Mouse BAC clone: RP23-392-P11 National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2020-09-23) RRID:RGD_39128172 39128239 GK/CskCrlj The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. To Chugai Pharmaceutical Co. To Charles River Japan in 1995. Charles River Laboratories Japan inbred Unknown RRID:RGD_39128239 39128242 SD-Vwfem1Mcwi-/- CRISPR/Cas9 mediated gene editing resulted a 130,938-bp deletion between 32-bp in front of the 5' end of Exon 1 and 122bp after the stop codon. MCW Gene Editing Rat Resource Center, through Versiti Blood Research Institute; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2020-10-09) Vwfem1Mcwi 39457948 4 161723415 161854766 1 - by flanking markers 4 225098521 225229257 1 - by flanking markers 4 158085059 158219525 1 - by flanking markers 4 158360152 158491539 1 - by flanking markers RRID:RGD_39128242 39131285 SD-Tg(DIO-mCherry)2Ottc This Cre recombinase reporter rat expressing mCherry was generated by backcrossing Sprague-Dawley to LE-Tg(DIO-mCherry)2Ottc (RGD:8693598). The transgene contains Cre recombinase reporter rat expressing mCherry driven by the EF1 alpha promoter. Optogenetics and Transgenic Technology Core transgenic Unknown RRID:RGD_39131285 39456105 F344/StmMcwi F344/StmMcwi was redelivered from F344/Stm which was derived from F344/DuCrlj. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu inbred Live Animals (as of 2023-02-14) RRID:RGD_39456105 39456107 LE/StmMcwi The LE/StmMcwi was rederived from LE/Stm and maintained at Medical College of Wisconsin. The LE/Stm rats were introduced into Saitama Cancer Center Research Institute in 1969 from a closed colony of Long Evans rats maintained in the Ben May Laboratory for Cancer Research, University of Chicago. A mutant with red-eyed dilution was found in 1970 in the Long-Evans colony, and the mutation was fixed by selective mating. Thereafter, they were maintained by sister-brother mating more than F50. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu inbred Live Animals (as of 2023-02-14) RRID:RGD_39456107 39456108 SD-Trpv4em1Sage TRPV4 gene?specific zinc finger constructs directed against exon 13, containing the coding sequence for part of TM5, the pore region, and TM6, were injected in zygotes from Sprague-Dawley rats. An animal with an 899 bp deletion in the TRPV4 gene was selected as a founder for further breeding. This deletion completely removes exon 13, plus parts of intron 12-13 and intron 13-14 . mutant Unknown Trpv4em1Sage 39456109 12 43226933 43265889 1 - by flanking markers 12 49492064 49529956 1 - by flanking markers 12 47698915 47737902 1 - by flanking markers 12 41938533 41977517 1 - by flanking markers RRID:RGD_39456108 39457682 LCR-mtHCR/Tol Mitochodrial genome of LCR/ was selectively replaced by HCR to create this conplastic strain; these have the mitochondrial genome of HCRl on LCR nuclear genetic background University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614 conplastic Unknown RRID:RGD_39457682 39457683 HCR-mtLCR/Tol Mitochodrial genome of HCR/ was selectively replaced by LCR to create this conplastic strain; these have the mitochondrial genome of LCRl on HCR nuclear genetic background University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614 conplastic Unknown RRID:RGD_39457683 39457699 LCR/Tol Low-capacity runners Artificially selected for aerobic running capacity from the genetic heterogenous rats; these were selected for low capacity based on distance run to exhaustion on a motorized treadmill. University of Toledo College of Medicine and Life Sciences, Toledo, Ohio. inbred Unknown RRID:RGD_39457699 39457701 HCR/Tol High-capacity runners Artificially selected for aerobic running capacity from the genetic heterogenous rats; these were selected for high capacity based on distance run to exhaustion on a motorized treadmill. University of Toledo College of Medicine and Life Sciences, Toledo, Ohio. inbred Unknown RRID:RGD_39457701 39457945 WI- Lpar1m1Hubr The Lpar1 mutant rat line was generated by target-selected ENU-driven mutagenesis of male MSH6 knockout rats, and high-throughput resequencing of genomic target sequences in progeny from mutagenized rats revealed an ENU-induced missense mutation in Lpar1 that resulted in the change of a methionine into an arginine (p.M318R) in the 8th helix and that was predicted to be deleterious for protein function. Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands. Hera Biolabs, Taconic. mutant Unknown Lpar1m1Hubr 126848739 5 76449470 76571458 1 - by flanking markers 5 79707131 79825313 1 - by flanking markers 5 75557038 75678067 1 - by flanking markers 5 73229047 73347874 1 - by flanking markers RRID:RGD_39457945 39457947 SD-Bckdkm1Dbsa The frogleg phenotype arose in a breeding colony of Sprague-Dawley rats which had originated with animals purchased from Taconic Farms (Hamilton, NY). The frogleg rats, which require no special husbandry, were bred and maintained at Spring Valley Laboratories, Inc (Woodbine,MD). The complex phenotype seen in the frogleg rat arises from a missense mutation (p.G369E) in the gene Bckdk. Spring Valley Laboratories, Inc (Woodbine,MD) mutant Unknown RRID:RGD_39457947 39457950 SD-Ngly1em1Ta-/- The homozygous Ngly1 mutant rats are littermates of cross of heterozygotesNgly1 mutant rats . The mutations created by CRISPR/Cas9 contained 2.6 kb deletions in exon 11 and exon 12 and a 3' flanking region of the Ngly1. Two single-guideRNA (sgRNA) sequences targeting sites upstream (5'-sgRNA;5'-cagaggaattgtgatagtacagg-3')anddownstream(3'-sgRNA; 5'-ccagttattcataccatggtaaa-3') of the exon 11, exon 12 and a 3'flanking region of the ratNgly1genome, respectively. By the time of deposition, this strain was crossed twice to Crl:CD (SD). "Homozygous rats are obtained by crossing between heterozygous rats. Maintain the strain by crossing between heterozygous rats or by backcrossing to Crl:CD (SD) rats. Homozygous rats, both females and males, have no record of pregnancy and reproduction. They are more likely to be infertile." National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2021-07-22) Ngly1em1Ta 149735565 15 10704196 10750564 1 - by flanking markers 15 14450836 14501356 1 - by flanking markers 15 10405453 10455973 1 - by flanking markers 15 9153738 9210228 1 - by flanking markers RRID:RGD_39457950 40818253 LE-Dyrk1aem1Mcwi The rat strain was produced by injecting CRISPR/Cas9 targeting rat Dyrk1a into Crl:LE embryos. The result is a 14-bp deletion in exon 3 Generated with support from the Simons Foundation Autism Research Initiative (SFARI); MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown RRID:RGD_40818253 40818401 M520/NRrrcMcwi To N 1951 from Heston at F51. Developed by Curtis at Columbia University Institute for Cancer Research, 1920; to Heston, 1949 at F49. It was then sent to Rat Resource and Research Center (RRRC). Medical College of Wisconsin received live animals from cryo-resuscitated pairs at RRRC in 2009. inbred Unknown RRID:RGD_40818401 40924649 Beta IIM Nine inbred lines developed from random-bred colony maintained by B. Houssay since 1948. Inbreeding and upward selection of body weight and fertility were performed in every line. Groups of rats from lines 'b' were separated in 1958 and raised at the School of Medicine at Rosario. In 1976, some degree of overweight was found in the original 'b' group and in 1980, the obesity group was identified as Beta line. School of Medicine at Rosario, Argentina inbred Unknown RRID:RGD_40924649 40924650 Alpha IIM Nine inbred lines developed from random-bred colony maintained by B. Houssay since 1948. Inbreeding and upward selection of body weight and fertility were performed in every line. Groups of rats from lines 'b' and 'alpha' were separated in 1958 and 1972 respectively and raised at the School of Medicine at Rosario. This line alpha (Alpha IIM) ), obtained from the F1 'a' X 'd', was used as control for the obese Beta line (RGD:40924649). School of Medicine at Rosario, Argentina inbred Unknown RRID:RGD_40924650 40924656 BN.ZUC-Leprfa Established as congenics by introducing fa from 13M/Vc to BN/Crl mutant Unknown (as of 2021-01-19) Leprfa 13432153 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RGD_40924656 40924661 LA-cp/NRll This corpulent rat used by Rudolph L Leibel's laboratory was developed at the National Institutes of Health (NIH). It was a congenic strain initially derived by mating a male Koletsky rat that was heterozygous for the corpulent gene (cp/ +) to a female Lister Albany/NIH (LAIN) rat. This congenic carrying the recessive Leprcp (RGD:11570565) identified in in the obese spontaneously hypertensive Koletsky rat. mutant Unknown Leprcp 11570565 5 122320075 122503449 1 - by flanking markers 5 124380327 124556585 1 - by flanking markers 5 120503475 120682281 1 - by flanking markers 5 116294409 116477904 1 - by flanking markers RRID:RGD_40924661 41404646 SD-Lrp5em1Vari CRISPR/Cas9 system was used to introduce a 18-bp deletion of exon 2 in the rat Lrp5 gene of Crl:SD embryos. mutant Unknown Lrp5em1Vari 41404647 1 206102750 206206350 1 - by flanking markers 1 225689353 225793075 1 - by flanking markers 1 218816833 218920147 1 - by flanking markers 1 200814247 200917581 1 - by flanking markers RRID:RGD_41404646 41404648 SD-Lrp5em2Vari CRISPR/Cas9 system was used to introduce a 22-bp deletion at the sgRNA2 site of exon 2 in the rat Lrp5 gene of Crl:SD embryos. mutant Unknown Lrp5em2Vari 41404650 1 206102750 206206350 1 - by flanking markers 1 225689353 225793075 1 - by flanking markers 1 218816833 218920147 1 - by flanking markers 1 200814247 200917581 1 - by flanking markers RRID:RGD_41404648 41404651 SD-Lrp5em3Vari CRISPR/Cas9 system was used to introduce an inversion coupled with small deletions in the exon 2 at both the sgRNA1 (11 bp) and sgRNA2 sites (3 bp) in the rat Lrp5 gene of Crl:SD embryos. mutant Unknown Lrp5em3Vari 41404652 1 206102750 206206350 1 - by flanking markers 1 225689353 225793075 1 - by flanking markers 1 218816833 218920147 1 - by flanking markers 1 200814247 200917581 1 - by flanking markers RRID:RGD_41404651 41404660 GK/Jpe The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. The GK line was established by repeated inbreeding from Wistar rats selected at the upper limit of normal distribution for glucose tolerance. Repeated selection of rats with tendency to lowest glucose tolerance resulted in clear-cut glucose intolerance after five generations.Until the end of 1980s, Center for Neurosciences and Cell Biology of Coimbra, University of Coimbra, Coimbra, Portugal inbred Unknown RRID:RGD_41404660 41404661 W/Jpe Inbred Wistar rats maintained at Center for Neurosciences and Cell Biology of Coimbra, University of Coimbra, Coimbra, Portugal Center for Neurosciences and Cell Biology of Coimbra, University of Coimbra, Coimbra, Portugal inbred Unknown RRID:RGD_41404661 41404705 SD-Shank3em1Bux The mutant rats were generated using zinc-finger nuclease (ZFN) technology to target exon 6 of the ankyrin repeat domain of rat Shank3. The resulting mutant has a 68-base pair deletion in exon 6 leading to a premature stop codon. mutant Unknown Shank3em1Bux 41404706 7 127817026 127877875 1 - by flanking markers 7 130159246 130220171 1 - by flanking markers 7 130474278 130534679 1 - by flanking markers 7 120568707 120630796 1 - by flanking markers RRID:RGD_41404705 41404723 DA.W-Ncf1W/Rhd The Wistar Ncf1 (Ncf1W) allele was backcrossed to the DA background for 10 generations Section for Medical Inflammation Research, Lund University, Lund, Sweden. congenic Unknown Ncf1W 41404724 RRID:RGD_41404723 41408337 DA.F344-Dpp4DPPIV/SvH Generation of the congenic strain was started with an initial cross between F344/Crl(Wiga)SvH-Dpp4m females, homozygous for the loss-of-function mutation in the Dpp4 gene on RNO3 and a DA/Ztm wild type male rat. The DP4 deficient congenic DA strain is maintained via brother=sister mating Hannover Medical School, Hannover, Germany mutant Unknown Dpp4DPPIV 12792942 3 44279255 44360283 1 - by flanking markers 3 54957146 55038628 1 - by flanking markers 3 48291055 48372672 1 - by flanking markers 3 46962243 47043870 1 - by flanking markers RRID:RGD_41408337 41408339 WI.SD-PcloTn(sb-B-Geo)Fkh The Sprague-Dawley transposon mutagenesis spermatogonial gene trap library was screen to generate rats with a disrupted Pclo gene in Wistar rat background. The transposon element was integrated into exon 3 of the Pclo genomic sequence, leading to a premature stop in the reading frame. University of Texas Southwestern Medical Center, Dallas TX mutant Unknown PcloTn(sb-B-Geo)Fkh 41408340 4 15911051 16269090 1 - by flanking markers 4 16428814 17031648 1 - by flanking markers 4 16454904 17058921 1 - by flanking markers 4 19691439 20050015 1 - by flanking markers RRID:RGD_41408339 41410881 WI-Grm2em1 This mutant rat strain was produced by Transposagen Biopharmaceutical and available in mGluR2+/- breeding pairs. The genome modification created a premature stop codon insertion that causes a nonsense mutation at amino acid C407, deleting the transmembrane and intracellular domains of the receptor and rendering the gene nonfunctional. Transposagen Biopharmaceutical mutant Unknown Grm2em1 41410882 8 111837086 111850133 1 - by flanking markers 8 114705123 114718193 1 - by flanking markers 8 115344999 115358628 1 - by flanking markers 8 107280099 107293159 1 - by flanking markers RRID:RGD_41410881 41412170 BBDR/RhwMcwi This strain was given to Medical College of Wisconsin by Ake Lernmark and maintained there. Medical College of Wisconsin, Milwaukee WI inbred Unknown RRID:RGD_41412170 41412172 BBDR.BBDP-(D4Mit6-D4Mit24)/RhwMcwi The lymphopenia locus from diabetic proned BBDP rat was transferred onto the genome of diabetic-resistant BB rat by marker-assisted selection in nine cycles of cross-intercross breeding. This congenic strain from Ake Lernmark, Laboratory, University of Washington, Seattle, Washington to Medical College of Wisconsin. Medical College of Wisconsin, Milwaukee, WI, USA congenic Unknown 4 75732943 78039637 1 - by flanking markers 4 141978848 144249450 1 - by flanking markers 4 77307388 79575658 1 - by flanking markers 4 76647384 78882945 1 - by flanking markers RRID:RGD_41412172 41412186 BBDP/Wor Diabetic prone BB rats. The Biobreeding rats (BB) spontaneously developed autoimmune diabetes mellitus were found in a closed colony of outbred WI (Wistar) rats at the Bio-Breeding Laboratories, Ottawa, Ontario in 1974. In 1977, Butler et al. began inbreeding BB rats at the University of Massachusetts Medical Center (laboratory code Wor) with 300 breeders purchased from the Bio-Breeding Laboratories. In 1978, during inbreding, pathogen-free rodent barrier system was introduced and and 2 strains were produced: disease prone (DP) and disease resistant (DR) by selected progenies were diabetic (DP) or remained diabtes free (DR). inbred Unknown RRID:RGD_41412186 41457452 WI-Prdm14em10Nips Prdm14 mutation was induced by introducing ribonucleic complexes (crRNA, tract RNA and Cas9 protein) into Crlj:WI rat embryos using electroporator. The resulting mutation is a 4412-bp deletion in exon 1 to 4. Homozygous Prdm14 knocked-out rats have the germ cell-deficient phenotype. Section of Mammalian Transgenesis, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN mutant Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2021-02-24) Prdm14em10Nips 41457453 5 10550222 10570255 1 - by flanking markers 5 5710076 5730560 1 - by flanking markers 5 6082163 6092712 1 - by flanking markers RRID:RGD_41457452 42721973 LEW/SsNArc This strain is now maintained at Animal Resources Centre in Canning Vale, WA 6970 AUSTRALIA. The LEW rats were received from National Institutes of Health , Bethesda MD, USA. inbred Unknown RRID:RGD_42721973 42721974 LEW-Nek8lpk/Arc The Lewis Polycystic Kidney (LPK) rat is a spontaneous mutant identified in the LEW colony (LEW/SsNArc) maintained at Animal Resources Centre in Canning Vale, WA 6970 AUSTRALIA. The causal gene is identified as a non-synonymous mutation R650C in the NIMA (never in mitosis gene a)- related kinase 8 ( Nek8) gene. mutant Unknown Nek8lpkArc 42721975 10 64458886 64470044 1 - by flanking markers 10 66196993 66230588 1 - by flanking markers 10 65404489 65439059 1 - by flanking markers 10 63060868 63073546 1 - by flanking markers RRID:RGD_42721974 42721977 SD-Pde6bem1Baek Cpf1 mRNA (50 ng per uL) and CRISPR RNA (100 ng per uL) were co-microinjected into the cytoplasm of pronuclear stage embryos; surviving embryos were transplanted into the oviducts of pseudo-pregnant surrogate mothers to generate live animals. A Pde6b-mutant rat line with an 11-bp deletion in exon 1 was established. Western blot analysis confirmed deficiency of Pde6b protein in the homozygous mutant retina, indicating successful generation of Pde6b-deficient rats with Cpf1-mediated gene targeting. Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea mutant Unknown Pde6bem1Baek 42721979 14 1871037 1914170 1 - by flanking markers 14 2327104 2370811 1 - by flanking markers 14 2328690 2371913 1 - by flanking markers 14 1323310 1366450 1 - by flanking markers RRID:RGD_42721977 42722004 F344-Tg(HIV)1Hsd Noninfectious clone containing gag-pol-deleted HIV-1 provirus under the viral LTR promoter was microinjected into fertilized one-cell Sprague�Dawley � Fisher 344/NHsd F1. Female founder with opaque cataracts was mating with wil-type Fischer 344/NHsd. Tg rats from line 1 contained 20�25 copies. transgenic Unknown RRID:RGD_42722004 45073130 SD-Fmr1em1Mzhe The CRISPR/Cas9 system was used to introduce deletions/mutations in exon 4 of the rat Fmr1 gene of outbred Sprague- Dawley embryos. The resulting mutation is a deletion of five amino acids and a G-A mutation in the Fmr1 gene. This genetic modification results in a frame-shift starting from the second Agenet-like 2 domain in the Fmr1 protein. The laboratory animal center of Peking University. mutant Unknown Fmr1em1Mzhe 124715480 X 154756031 154793782 1 - by flanking markers 1 150408220 150445658 1 - by flanking markers X 154684924 154722369 1 - by flanking markers X 147240239 147278057 1 - by flanking markers RRID:RGD_45073130 45073133 SD-Pon1em1Lizh CRISPR/Cas9 system was used to introduce a 342-bp deletion in exon 4 of rat PON1 gene in Sprague- Dawley embryos. The destruction of Pon1 gene caused the absence of the the expression of Pon1 mRNA, protein in liver, spleen and thymus in the Pon1 homozygous knock-out rat. Institute of Laboratory Animal Science of Peking Union Medical College mutant Unknown Pon1em1Lizh 124715481 4 29936314 29964821 1 - by flanking markers 4 30156712 30183204 1 - by flanking markers 4 30249749 30276297 1 - by flanking markers 4 33294737 33325759 1 - by flanking markers RRID:RGD_45073133 53621137 SD-Tg(Wnt1-cre/ERT2)AppscRrrc The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Wnt1 gene linked by 2A peptide. This model is used to lineage tracing of neural crest cells by tissue specific expression of creERT2 Rat Resource and Research Center transgenic Live Animals (as of 2021-07-19) RRID:RRRC_00868 56677892 SD-Tg(GFAP-cre/ERT2)AppscRrrc The 'docking site ready (DSR)' rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. With integrase, these TARGAT/DSR rats are used as embryo donors. TARGATT rat embryos will be microinjected with a mixture of TARGATT Cre DNA constructs containing human GFAP promoter, a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The astrocyte tissue-specific expression of a CreERT2 is also tamoxifen-dependent. Rat Resource and Research Center transgenic Live Animals (as of 2021-07-19) RRID:RRRC_00876 58366897 SD-Tg(Tie2-cre/ERT2)AppscRrrc The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Tie2 gene linked by 2A peptide. This model is used to lineage tracing of vascular endothelial cells by tissue specific expression of creERT2 Rat Resource and Research Center transgenic Live Animals (as of 2021-07-19) RRID:RRRC_00877 124713544 W-Cyp27b1em1Thka This strain was established by injecting Jcl:Wistar embryo with CRISPR/Cas9 system to delete the cysteine at position 462 in exon 8, which is the 5th ligand of heme iron and an active center of Cyp27b1. The resulting mutation is a 25 amino acid deletion (75 bp deletion) in the target site. The mutant was maintained with CE-2 formula diet (CLEA Japan, Inc., Tokyo, Japan) containing 1.15% calcium and 2,100 IU vitamin D3/kg diet. Homozygotes Cyp27b1 mutants were maintained by mating of heterozygotes. mutant Unknown Cyp27b1em1Thka 124713545 7 70512763 70517707 1 - by flanking markers 7 70333150 70340006 1 - by flanking markers 7 62869340 62876242 1 - by flanking markers RRID:RGD_124713544 124713546 W-Vdrem1Thka This strain was established by injecting Jcl:Wistar embryo with CRISPR/Cas9 system to disrupt the array near the arginine codon (CGC) at position 270 of the Vdr gene. This resulted in changing arginine codon to Leu at p.270 of the Vdr gene. They were allowed food and water ad libitum and fed a CE-2 formula diet ( CLEA Japan, Inc., Tokyo, Japan) containing 1.15% calcium and 2,100 IU vitamin D3/kg diet. The Vdr (R270L) rats for analysis were fed an F-2 formula diet (Oriental Yeast Co., Tokyo, Japan) containing 0.74% calcium and 2000 IU vitamin D/kg diet12 after weaning because the CE-2 diet partially reversed their rickets symptoms. Homozygotes Vdr(R270L mutants were maintained bymating of heterozygotes. mutant Unknown Vdrem1Thka 124713547 7 136567614 136617280 1 - by flanking markers 7 139536241 139585928 1 - by flanking markers 7 139344452 139394138 1 - by flanking markers 7 128987981 129037677 1 - by flanking markers RRID:RGD_124713546 124713548 W-Vdrem2Thka This strain was established by injecting Jcl:Wistar embryo with CRISPR/Cas9 system to disrupt the array near the arginine codon (CGC) at position 270 of the Vdr gene. This resulted in 1bp deletion and caused premature stop at p266 of the Vdr gene. They were allowed food and water ad libitum and fed a CE-2 formula diet ( CLEA Japan, Inc., Tokyo, Japan) containing 1.15% calcium and 2,100 IU vitamin D3/kg diet. The Vdr knock out rats for analysis were fed an F-2 formula diet (Oriental Yeast Co., Tokyo, Japan) containing 0.74% calcium and 2000 IU vitamin D/kg diet12 after weaning because the CE-2diet partially reversed their rickets symptoms. Homozygotes Vdr knock out mutants were maintained by mating of heterozygotes. mutant Unknown Vdrem2Thka 124713550 7 136567614 136617280 1 - by flanking markers 7 139536241 139585928 1 - by flanking markers 7 139344452 139394138 1 - by flanking markers 7 128987981 129037677 1 - by flanking markers RRID:RGD_124713548 125093746 SD-Disc1em1Rst CRISPR/Cas9 system was used to introduce a 371-bp deletion of exon 2 in the rat Disc1 gene of one-cell Crl:SD embryos. This deletion caused non-sense mutation and early termination of translation. University of Wisconsin-Madison School of Medicine and Public Health, mutant Unknown Disc1em1Rst 125093747 19 55265116 55449375 1 - by flanking markers 19 68529791 68769050 1 - by flanking markers 19 57818838 58069992 1 - by flanking markers 19 53014201 53223617 1 - by flanking markers RRID:RGD_125093746 125097486 SD-Nr3c1em1Kuan The CRISPR/Cas9 genome editing system was used to created a conditional knockout of floxed Nr3c1 gene in outbred SD embryos. The LoxP sequences were inserted in the 5prime and 3prime sides of exon 3. For CaMKIIa cell-specific knockdown, 0.1 ul of AAV9.CamKII.HI.eGFP-Cre.WPRE.SV40 (CaMKIIa Cre) [Penn Vector Core] was injected bilaterally and allowed a minimal of 3 weeks to incubate. Department Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, United States mutant Unknown Nr3c1em1Kuan 125097487 18 32371496 32459145 1 - by flanking markers 18 31408742 32348480 1 - by flanking markers 18 31728373 32704022 1 - by flanking markers 18 31271681 31393320 1 - by flanking markers RRID:RGD_125097486 125097491 WI.WDB-Prdm14tm1(H2BVenus)Nips Targeting vector was designed to replace 1st and 4th exons encoding DNA-binding domain of Prdm14 locus with H2BVenus. The vector was introduced into WDB/Nips-ES1/Nips (RGD ID:10054010) embryonic stem cells by electroporation . Targeted ES cells were injected into Crlj:WI blastocysts to produce chimeric rats. The chimeric rats were crossed with Crlj:WI rats to produce heterozygous founder rats. These rat strains are being maintained by crossing the founder rats with Crlj:WI rats. Homozygous Prdm14 knocked-in rats have the germ cell-deficient phenotype. Section of Mammalian Transgenesis, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Aichi 444-8787, JAPAN mutant Live Animals; Cryopreserved Embryo (as of 2021-04-01) Prdm14tm1(H2BVenus)Nips 126781696 5 10550222 10570255 1 - by flanking markers 5 5710076 5730560 1 - by flanking markers 5 6082163 6092712 1 - by flanking markers RRID:RGD_125097491 125097492 WI-Sall1em1Nips Sall1 mutation was induced by injecting a mix of two pX330 expressing Cas9 and sgRNA targeting the sequence into Crlj:WI rat embryos. The resulting mutation is a 4456-bp deletion in exon 2 to 3. Homozygous Sall1 knocked-out rats had the anephric phenotype at E21.5, and died at postnatal Day-1. Section of Mammalian Transgenesis, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Aichi 444-8787, JAPAN. mutant Live Animals; Cryopreserved Embryo (as of 2021-04-01) Sall1em1Nips 126781694 19 19277337 19293298 1 - by flanking markers 19 34377838 34395131 1 - by flanking markers 19 23387737 23405025 1 - by flanking markers 19 18005782 18022705 1 - by flanking markers RRID:RGD_125097492 125097494 WI.WDB-Sall1tm4(tdTomato)Nips Targeting vector was designed to replace 2nd and 3rd exons encoding DNA-binding domain of Sall1 locus with tdTomato. The vector was introduced into WDB/Nips-ES1/Nips (RGD ID:10054010) embryonic stem cells by electroporation.Targeted ES cells were injected into Crlj:WI blastocysts to produce chimeric rats. The chimeric rats were crossed with Crlj:WI rats to produce heterozygous founder rats..These rat strains are being maintained by crossing the founder rats with Crlj:WI rats. Homozygous Sall1 knocked-in rats had the anephric phenotype at E21.5, and died at postnatal Day-1. Section of Mammalian Transgenesis, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi 444-8787, JAPAN mutant Live Animals; Cryopreserved Embryo (as of 2021-04-01) Sall1tm4(tdTomato)Nips 126781695 19 19277337 19293298 1 - by flanking markers 19 34377838 34395131 1 - by flanking markers 19 23387737 23405025 1 - by flanking markers 19 18005782 18022705 1 - by flanking markers RRID:RGD_125097494 125097496 Iar:WIC Iar:Wistar-Imamichi Institute for Animal Reproduction in Japan outbred Unknown Metabolism; Development RRID:RGD_125097496 125097497 WIC;WI;WDB-Kiss1tm8Nips This strain was made by electroporation of WDB/Nips-ES1/Nips (RGD ID:10054010) embryonic stem (ES) cells with a targeting vector. A targeting vector was designed to insert two loxP sites encompassing exons 2 and 3 of the Kiss1 gene coding for 52-amino acid rat kisspeptin-1 (Kiss1) and a neomycin-resistance gene into the Kiss1 locus in rat ES cells via homologous recombination. Targeted ES cells were injected into Crlj:WI blastocysts to produce chimeric rats. The chimeric rats were crossed with Iar:Wistar-Imamichi rats to produce heterozygous founder rats. This rat strain is being maintained by crossing the founder rat with Iar:Wistar-Imamichi rats. Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN mutant Live Animals; Cryopreserved Embryo (as of 2021-04-01) Kiss1tm8Nips 126781693 13 46244786 46247288 1 - by flanking markers 13 55582365 55590432 1 - by flanking markers 13 50529506 50537603 1 - by flanking markers 13 44774823 44780707 1 - by flanking markers RRID:RGD_125097497 126777684 WI-Mkxem1Asah The CRISPR/Cas9 genome editing system targeting exon 2 of rat Mkx gene was injected to the Wistar embryo to generate this knock out rat strain with 14- bp deletion causing frameshift mutation in the gene. mutant Unknown Mkxem1Asah 126777685 17 63631540 63710138 1 - by flanking markers 17 62321329 62332471 1 - by flanking markers 17 60537615 60553284 1 - by flanking markers 17 55077073 55156877 1 - by flanking markers RRID:RGD_126777684 126777687 WKY-Dnd1ter/Ztm A spontaneous mutation (ter) leading to the formation of congenital ovarian and testicular tumors was detected in the WKY/Ztm rat strain. Sequence analysis detected a point mutation in exon 4 of the rat Dnd1, which introduces a premature stop codon assumed to cause a truncation of the Dnd1 protein. This recessive ter mutation has a complete penetrance of teratocarcinogenesis and infertility of both sexes in homozygous genotype. Institute for Laboratory Animal Science, Hannover Medical School (MHH), Germany mutant Unknown Dnd1ter 150340622 18 29464691 29467315 1 - by flanking markers 18 29312395 29315019 1 - by flanking markers 18 29608588 29611212 1 - by flanking markers 18 28378692 28381316 1 - by flanking markers RRID:RGD_126777687 126779578 LOU/MWsl A substrain of LOU/M maintained in the laboratory of Dr. H. Bazin at Universite de Louvain. Experimental Immunology Unite Faculty of Medicine Clos Chapelle aux Champs 30.56 Bruxelles 1200 BELGIUM inbred Unknown RRID:RGD_126779578 126779586 SD-Csf1rtm(EGFP)+/-/Tset Targeting vector was designed to disrupt the first exon encoding of Csf1r gene with a drug selection cassette by homologous recombination in Rat ESC clone DAK31-C2. Sprague-Dawley females were used as embryo donors and pseudo-pregnant recipients University of Edinburgh, United Kingdom mutant Unknown Csf1rtm(EGFP)Tset 126781692 18 57080324 57107295 1 - by flanking markers 18 55662670 55689297 1 - by flanking markers 18 56414493 56458300 1 - by flanking markers 18 54546673 54590418 1 - by flanking markers RRID:RGD_126779586 126779587 DA-Csf1rtm(EGFP)+/-/Hume Heterozygotes "SD-Csf1rtm(EGFP)+/-/Tset" were back-crossed for at least 7 generations to the inbred dark agouti (DA) background from the Animal Resource Centre, Western Australia. Department of Microbiology, University of Queensland, Brisbane, Queensland 4072 Australia mutant Unknown Csf1rtm(EGFP)Tset 126781692 18 57080324 57107295 1 - by flanking markers 18 55662670 55689297 1 - by flanking markers 18 56414493 56458300 1 - by flanking markers 18 54546673 54590418 1 - by flanking markers RRID:RGD_126779587 126779591 SD-Csf1rtm(EGFP)-/-/Tset Targeting vector was designed to disrupt the first exon encoding of Csf1r gene with a drug selection cassette by homologous recombination in Rat ESC clone DAK31-C2. Sprague-Dawley females were used as embryo donors and pseudo-pregnant recipients. The homozygotes were obtained by crossing of heterozygotes. University of Edinburgh, United Kingdom mutant Unknown Csf1rtm(EGFP)Tset 126781692 18 57080324 57107295 1 - by flanking markers 18 55662670 55689297 1 - by flanking markers 18 56414493 56458300 1 - by flanking markers 18 54546673 54590418 1 - by flanking markers RRID:RGD_126779591 126779592 DA-Csf1rtm(EGFP)-/-/Hume Heterozygotes "SD-Csf1rtm(EGFP)+/-/Tset" were back-crossed for at least 7 generations to the inbred dark agouti (DA) background from the Animal Resource Centre, Western Australia. The homozygotes were obtained by crossing of heterozygotes Department of Microbiology, University of Queensland, Brisbane, Queensland 4072 Australia mutant Unknown Csf1rtm(EGFP)Tset 126781692 18 57080324 57107295 1 - by flanking markers 18 55662670 55689297 1 - by flanking markers 18 56414493 56458300 1 - by flanking markers 18 54546673 54590418 1 - by flanking markers RRID:RGD_126779592 126781838 SD-Tg(PDGFB-cre/ERT2)AppscRrrc The 'docking site ready (DSR)' rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. With integrase, these TARGAT/DSR rats are used as embryo donors. TARGATT rat embryos will be microinjected with a mixture of TARGATT Cre DNA constructs containing human PDGFB promoter, a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The brain tissue-specific expression of a CreERT2 is also tamoxifen-dependent. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2021-07-19) RRID:RRRC_00869 126781839 SD-Tg(Olfr16-cre/ERT2)AppscRrrc The 'docking site ready (DSR)' rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. With integrase, these TARGAT/DSR rats are used as embryo donors. TARGATT rat embryos will be microinjected with a mixture of TARGATT Cre DNA constructs containing mouse Olfr16 (MOR23) promoter, a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The Olfactory sensory neuronal lineage tissue-specific expression of a CreERT2 is also tamoxifen-dependent. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2021-07-19) RRID:RRRC_00870 126781841 SD-Tg(Mnx1-cre/ERT2)AppscRrrc The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Mnx1 (HB9) gene linked by 2A peptide. This model is used to lineage tracing of motor neurons by tissue specific expression of creERT2 Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryorecovery (as of 2021-07-19) RRID:RRRC_00872 126781842 SD-Tg(Drd1-cre/ERT2)AppscRrrc The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Drd1 (Drd1a) gene linked by 2A peptide. This model is used to lineage tracing of dopamine D1 receptor expressing neurons Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryorecovery (as of 2021-07-19) RRID:RRRC_00873 126781843 SD-Tg(Gad1-cre/ERT2)AppscRrrc The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Gad1 (Gad67) gene linked by 2A peptide. This model is used to lineage tracing of glutamate decarboxylase 1 expressing cells such as GABAergic neurons, islet cells and spermatocytes. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryorecovery (as of 2021-07-19) RRID:RRRC_00874 126781844 SD-Tg(SMHC-cre/ERT2)AppscRrrc The 'docking site ready (DSR)' rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. With integrase, these TARGAT/DSR rats are used as embryo donors. TARGATT rat embryos will be microinjected with a mixture of TARGATT Cre DNA constructs containing rabbit smooth muscle myosin heavy chain (SMHC) gene promoter, a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The Olfactory sensory neuronal lineage tissue-specific expression of a CreERT2 is also tamoxifen-dependent. Rat Resource and Research Center transgenic Live Animals (as of 2021-07-19) RRID:RRRC_00878 126781845 SD-Tg(CAG-GFP-LacZ)AppscRrrc A transgenic line carrying random insertion of transgene cassette CAG-LSL-GFP-LacZ (LSL: loxp-Stop-Loxp). It is used as a Cre reporter/test line expressing GFP and lacZ. Used as lineage tracing tool rat line by mating with tissue specific cre or cre/ERT2 line Rat Resource and Research Center transgenic Unknown RRID:RRRC_00879 126790464 SD-Ube3aem1Jue The CRISPR/Cas9 genome editing system was injected into fertilized Sprague-Dawley rat embryos and inserted into a surrogate. Two genomic RNAs (gRNAs) were designed to target the 5ʹ-end of the Ube3a gene (upstream of the Ube3a coding sequence) and two gRNAs target sequences downstream of Ube3a. gRNA pairs were used on each end of the deletion to maximize the probability of a complete deletion of the 90-kb region encompassing the Ube3a gene. The 90 kb deletion in Ube3a was confirmed by genome sequencing. Only pups with maternal inheritance of the deletion carried traits for model of Angleman Syndrome. mutant Unknown Ube3aem1Jue 126790465 1 110729142 110816491 1 - by flanking markers 1 117745283 117834011 1 - by flanking markers 1 116586901 116678161 1 - by flanking markers 1 110070260 110161675 1 - by flanking markers RRID:RGD_126790464 126790469 F344.Cg-Foxn1rnu-/-/Jcl This congenic strain was established as a strain with the genetic background of F344/N onto which a segment from the nude rat containing the Foxn1rnu was transferred. Originally, hairless mutant (rnu) was observed in a colony of outbred hooded rats maintained at the Rowett Research Institute in Scotland. Backcrossing started at Central Institute for Experimental Animals in 1979 and thereafter the subline was transported to CLEA Japan, Inc for production and supply of these rats. CLEA Japan, Inc congenic Live Animals (as of 2021-04-22) Immuno deficiency RRID:RGD_126790469 126790472 F344.Cg-Foxn1rnu-/+/Jcl This congenic strain was established as a strain with the genetic background of F344/N onto which a segment from the nude rat containing the Foxn1rnu was transferred. Originally, hairless mutant (rnu) was observed in a colony of outbred hooded rats maintained at the Rowett Research Institute in Scotland. Backcrossing started at Central Institute for Experimental Animals in 1979 and thereafter the subline was transported to CLEA Japan, Inc for production and supply of these rats. CLEA Japan, Inc congenic Live Animals (as of 2021-04-22) Immuno deficiency RRID:RGD_126790472 126790496 SD-Shank2em13Sage The Shank2 KO rat line 13 was generated by zinc finger nuclease technology targeting exon 31 for deletion . Line 13 has a 437 bp deletion around and including the entire exon 31, thereby causing a frameshift and premature stop codon in all three known isoforms of the rat Shank2 mRNA mutant Unknown Shank2em13Sage 126790499 1 204399856 204855474 1 - by flanking markers 1 222118530 224450737 1 - by flanking markers 1 217149156 217593950 1 - by flanking markers 1 199146210 199590962 1 - by flanking markers RRID:RGD_126790496 126790511 Jcl:WIST CLEA Japan, Inc., Taconic Farms Inc. (USA), and Taconic Europe (Denmark) created the Global Alliance for Laboratory Animal Standardization (GALASTM) agreement in collaboration with the Central Institute for Experimental Animals to promote the international standardization of outbred stocks usable for safety testing in the field of toxicity and pharmacology. Based on these activities,Wistar Hannover GALAS rats are derived from the Han:WIST strain from the Zentral Institut fur Versuchstierzucht (ZfV) (Hannover, Germany). In 1989, 156 pairs were introduced from ZfV to the Institute for Biomedical Research (IBM) in Switzerland (IBM underwent a structural change [name change] to BRL Ltd. and RCC Ltd.). At and after the end of 1998, RCC Ltd. gave more than 50 pairs of pedigreed BrlHan:WIST rats to each GALAS member to use as seed rats for the Wistar Hannover GALAS strain. CLEA Japan, Inc outbred Live Animals (as of 2021-04-23) RRID:RGD_126790511 126790547 SD-Rin1em1-/-Hcz This strain was produced by injecting TALEN targeting the sequence of ratRin1 into SD embryos. The resulting mutation is a knock out of the gene. Department of Histology and Embryology, Basic Medical College, China Medical University, Shenyang 110122, China mutant Unknown Rin1em1Hcz 126790548 1 207671502 207676150 1 - by flanking markers 1 227359504 227364152 1 - by flanking markers 1 220335036 220342319 1 - by flanking markers 1 202355729 202362731 1 - by flanking markers RRID:RGD_126790547 126848737 WI- Msh6m1Hubr The Msh6 knockout mutant rat line was generated by target-selected ENU-driven mutagenesis on Crl:WI rats. The founder rat carried an ENU-induced premature stop codon in exon 4 of the Msh6 gene was bred to obtain homozygous animals. Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands. Hera Biolabs, Taconic. mutant Unknown Msh6m1Hubr 126848738 6 11525292 11542592 1 - by flanking markers 6 21616672 21634338 1 - by flanking markers 6 11644565 11662389 1 - by flanking markers 6 6562631 6579995 1 - by flanking markers RRID:RGD_126848737 126848740 SDT.Cg-Leprfa/JttJcl SDT fatty Leprfa allele from ZDF was introgressed into SDT rats using the speed congenic method. The newly establised congenic strain of a SDT rat for Leprfa was maintained by intercross between fa-heterozygous littermates in Japan CLEA Inc. CLEA Japan, Inc congenic Live Animals (as of 2021-05-06) RRID:RGD_126848740 126848751 RCS-Mertkrdyp/LavJcl This strain maintained at Japan JCLEA is homozygous at the pink eye (p) locus and homozygous for a deletion in the Mertk gene. CLEA Japan, Inc congenic Live Animals (as of 2021-04-28) Mertkrdy 40902839 RRID:RGD_126848751 126848763 ODS-Gulood+/+/ShiJcl Osteogenic disorder Shionagi rat, wild type This is the wild type control for ODS-Gulood/od/ShiJcl (RGD:4140404) . Dr. Susumu Makino and his colleagues found several animals that had gait abnormalities among Wistar rats maintained at Shionogi Co. They named these animals osteogenic disorder (OD) rats because they exhibited prominent bone and joint abnormalities and systemic bleeding. Subsequent studies revealed that these symptoms were derived from an ascorbic acid (vitamin C) deficiency arising from defective gulonolactone oxidase (GLO) activity. This characteristic was confirmed to be the result of a mutation involving the autosomal single recessive gene od. Scurvy due to L-gulonolactone oxidase deficincy; phenotype normalizes if supplied with ascorbic acid 300mg/kg/d. od/od rats are more susceptible to dental caries as compared with +/+ rats, in only amoun parous females. CLEA Japan, Inc inbred Live Animals (as of 2021-04-29) RRID:RGD_126848763 126848776 RCS-Mertkrdy+p/LavJcl This strain maintained at Japan JCLEA is homozygous at the pink eye (p) locus and homozygous for wild type Mertk gene. CLEA Japan, Inc congenic Live Animals (as of 2021-04-30) RRID:RGD_126848776 126848777 SD-Tg(HRAS)128NccJcl Hras128 is a transgenic rat, introduced human proto-type c-Ha-ras gene to Jcl:SD rat fertilized egg by Dr. Hiroyuki Tsuda, Natl. Cancer Center, in 1998. The strain has been kept by CLEA Japan from its creation and supplied to the related research organization after concluded an agreement with Natl. Cancer Center and Japan Science and Technology Agency (JST). This strain is carrying three copies of the human c-Ha-ras proto-oncogene, including its own promoter region. CLEA Japan, Inc transgenic Live Animals (as of 2021-04-30) RRID:RGD_126848777 126848778 SD-Tg(CAG-KRAS*G12V)301Jcl The transgene consisting of CAG promoter/loxP/neomycin resistant gene casette/lox/Ha-Kras*G12V (KrasV12) was injected into embryos of SD rat (RGD:8547938). This strain was generated at CLEA Japan,Inc. This strain is introduced 3 copies of hemagglutinin (HA) epitope tag connected HA-K-rasv12 gene expression cassette by using Cre/loxP system for controlling term/location expression of human mutated form K-rasv12 gene (changing glycine to valine at the 12 amino acid sequence) that normally floxed rat does not express K-rasv12 gene. CLEA Japan, Inc transgenic Live Animals (as of 2021-04-30) Oncology RRID:RGD_126848778 126848793 SS-Gper1em1Bj-/- CRISPR/Cas 9 was utilized to delete rat Gper1 gene in the one-cell embryos of SS/Jr rats. RNA validation performed via deletion PCR using a sense primer at the 5' end and an antisense primer at the 3' end showed a deletion PCR product of 544 bps versus wild-type PCR product of 1484 bps. The homozygous founders had complete deletion of Gper1 was confirmed by DNA sequenching. University of Toledo College of Medicine and life Sciences OH mutant Unknown Gper1em1Bj 151347865 12 15718615 15719893 1 - by flanking markers 12 19296086 19301691 1 - by flanking markers 12 17309122 17315267 1 - by flanking markers 12 15217217 15222679 1 - by flanking markers RRID:RGD_126848793 126848794 SHR-Zbtb16em1Ipcv+/- TALEN was used to target Zbtb16 (Plzf )in the SHR and one founder with a deletion of G at position 93 of the coding sequence (c.93delG) was identified. That deletion resulted in a frameshift downstream glycine 31 (p.Gly31fs). The frameshift mutation caused the incorporation of 20 aberrant amino acids downstream of the deleted G, followed by a stop codon. The founder was bred with SHR to generate more heterozygous animals. The homozygous animals die perinatally because of multiple developmental abnormalities. Institute of Biology and Medical Genetics, Charles University, Prague mutant Unknown Zbtb16em1Ipcv 150340624 8 51931530 52094813 1 - by flanking markers 8 51573252 51740759 1 - by flanking markers 8 52980226 53146765 1 - by flanking markers 8 48989376 49177011 1 - by flanking markers RRID:RGD_126848794 126848804 F344-Trpc4Tn(sb)1Bni The Sleeping Beauty transposon system was used to insert the sleeping beauty transposon into the first intron of the rat Trpc4 gene. Trpc4 knock-out (510 bp) and wild-type allele (905 bp) were confirmed using PCR and gel electrophoresis Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, B-3000 Leuven Belgium mutant Unknown Trpc4Tn(sb)Tngen 126848808 2 143350286 143485716 1 - by flanking markers 2 163115873 163282223 1 - by flanking markers 2 143433102 143605757 1 - by flanking markers 2 138307676 138476856 1 - by flanking markers RRID:RGD_126848804 126908010 SD-Kcnk3em1Ang-/- The homozygous Kcnk3 mutant rats are littermates of cross of heterozygotesKcnk3 mutant rats . The mutation created by CRISPR/Cas9 contained a 94- bp deletion in exon1 of resulted a premature stop codon. mutant Unknown Kcnk3em1Ang 126908015 6 25745923 25782144 1 - by flanking markers 6 36969843 37005778 1 - by flanking markers 6 27154274 27190209 1 - by flanking markers 6 25761487 25799153 1 - by flanking markers RRID:RGD_126908010 126908013 SD-Kcnk3em1Ang-/+ The heterozygous Kcnk3 mutant rats were created by CRISPR/Cas9. The mutated allele contained a 94- bp deletion in exon1 of resulted a premature stop codon. mutant Unknown Kcnk3em1Ang 126908015 6 25745923 25782144 1 - by flanking markers 6 36969843 37005778 1 - by flanking markers 6 27154274 27190209 1 - by flanking markers 6 25761487 25799153 1 - by flanking markers RRID:RGD_126908013 126925134 SD-Il36rntm1(Myh6-cre)Mhzh This line was produced by mating rats carrying Il36rnf/f allele and Myh6-cre-allele. The expression of Il36rn was knockout in cardiomyocytes. Nanjing University Model Animal Center. mutant Unknown Il36rntm1(Myh6-cre)Mhzh 126925161 3 2530402 2536999 1 - by flanking markers 3 1378833 1385430 1 - by flanking markers 3 1385256 1392275 1 - by flanking markers 3 7044419 7051016 1 - by flanking markers RRID:RGD_126925134 126925135 SD-Il1rl2tm1(Myh6-cre)Mhzh This line was produced by mating rats carrying IIl1rl2f/f allele and Myh6-cre-allele. The expression of Il1rl2 was knockout in cardiomyocytes. Nanjing University Model Animal Center. mutant Unknown Il1rl2tm1(Myh6-cre)Mhzh 126925159 9 39492187 39537792 1 - by flanking markers 9 46733619 46778352 1 - by flanking markers 9 47044870 47093679 1 - by flanking markers 9 42591658 42639351 1 - by flanking markers RRID:RGD_126925135 126925136 SD-Mstnem1Cqin ZFN constructs were designed to target the genomic region of rat Mstn exon 1. A ZFN construct engineered to target bp 277 to 281 of rat Mstn was used for the rat embryo injection. The # 6 founder was found to have sequence changed from GATCA to AGTC, resulting in a frame shift mutation within the open reading frame and generate an early termination codon, resulting in a truncated 109 amino acid peptide (wild type is 376). ZFN mutant founders were backcrossed to Spargue Dawley rats to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. mutant Unknown Mstnem1Cqin 151347430 9 45426831 45431658 1 - by flanking markers 9 52977371 52982198 1 - by flanking markers 9 53310977 53315804 1 - by flanking markers 9 48453982 48458809 1 - by flanking markers RRID:RGD_126925136 126925137 SD-Ogdhem1Yuyi The TALEN systems targeting Ogdh were injected to Sprague Dawley one cell embryos and an 8-bp deletion was identified in one founder animal. No homozygous rats were obtained from mating of heterozygotes that suggests embryonic lethal for the homozygotic mutant. Laboratory Animal Center of Zhengzhou university mutant Unknown Ogdhem1Yuyi 126925168 14 87022994 87090768 1 - by flanking markers 14 87376110 87442862 1 - by flanking markers 14 86414924 86481903 1 - by flanking markers 14 81150021 81217479 1 - by flanking markers RRID:RGD_126925137 126925138 SD-Ubdem1 This Ubd (FAT10) knockout rat strain was generated using theCRISPR-Cas9 technique in a Sprague Dawley (SD) background. The knockout allele has a 911 bp deletion of exon 2, leading to a truncated protein of Ubd. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006 mutant Unknown Ubdem1 126925166 20 1475944 1477895 1 - by flanking markers 20 3917777 3919728 1 - by flanking markers 20 1876175 1878126 1 - by flanking markers 20 1385487 1387438 1 - by flanking markers RRID:RGD_126925138 126925139 SD-Dnmt1tm1(Myh6-cre)Cqin To specifically knockout Dnmt1 in the myocardium, Cre-loxP system was used by crossing alpha -MHC-Cre rats with Dnmt1 cKO rats. Dnmt1+/- offspring positive for the alpha MHC-Cre transgene (double-positive) were selected. In the second round of crossbreeding, the double-positive rats were crossed with Dnmt1 cKO rats, and Dnmt1-/- offspring positive for the alpha MHC-Cre transgene were obtained as myocardium-specific Dnmt1-KO rats Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College (ZLF18003), Beijing, China mutant Unknown Dnmt1tm1(Myh6-cre)Cqin 126925165 8 19926995 19973256 1 - by flanking markers 8 21978830 22024656 1 - by flanking markers 8 21922515 21968495 1 - by flanking markers 8 19440611 19486659 1 - by flanking markers RRID:RGD_126925139 126925196 F344-Slc6a3m1Span This strain was identified in the N-ethyl-N-nitrosourea (ENU)-driven target-selected mutagenesis screen. A point mutation in the Slc6a3 (DAT) coding sequence (exon 3) with a T/G transversion at nucleotide position 471 was identified in a male rat. This nucleotide exchange leads to substitution of an asparagine amino acid residue by a lysine residue at position 157 (N157K) in the SLC6A3 (DAT) protein, which introduces new positive charge into the amino acid sequence. Central Institute of Mental Health Department of Psychopharmacology Central Institute of Mental Health Mannheim, mutant Unknown Slc6a3m1Span 126925197 1 30516568 30557540 1 - by flanking markers 1 33745060 33788878 1 - by flanking markers 1 32323011 32363983 1 - by flanking markers 1 29709443 29750413 1 - by flanking markers RRID:RGD_126925196 126925212 WI- Drd1m1Hubr The Drd1 mutant rat line was generated by target-selected ENU-driven mutagenesis on outbred Wistar rats. Sequencing of genomic target sequences in progeny from mutagenized rats revealed an ENU-induced missense mutation in Drd1. The mutation resulted in an isoleucine to serine exchange (Drd1I116S) in helix III of the protein. Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands. mutant Unknown Drd1m1Hubr 126925213 17 16655926 16658161 1 - by flanking markers 17 13211031 13215581 1 - by flanking markers 17 11099736 11104352 1 - by flanking markers 17 10540440 10544971 1 - by flanking markers RRID:RGD_126925212 126925756 SD-Cryba1Nuc1Dbsa This spontaneous mutation was identified in the offspring of pregnant Sprague-Dawley rats purchased from Taconic Farms. This mutant exhibited abnormal eye phenotype including nuclear cataracts and was called Nuc1 rat. Sequencing of the mutant allele revealed a 27 base pair insertion in exon 6 of Cryba1. The Johns Hopkins University School of Medicine The Wilmer Eye Institute The Johns Hopkins University School of Medicine Baltimore mutant Unknown Cryba1Nuc1Dbsa 126925758 10 63758929 63765451 1 - by flanking markers 10 66458061 66480390 1 - by flanking markers 10 65160777 65167504 1 - by flanking markers 10 62608373 62614726 1 - by flanking markers RRID:RGD_126925756 126925949 SD-Myh7bem1Blar+/- The Myh7b knockout SD rats were generated using the CRISPR/Cas9 system targeting exon 2, resulting 7 bases deletion of exon 2 and generated a new termination codon TGA in exon 3. The heterzygous Myh7b+/- rats were crossed to generate littermate controls. The birth ratio of wild type (WT):Myh7b+/-:Myh7b-/- was approximately 1:2:1, indicating that Myh7b-/- did not cause fetal death. Beijing Laboratory Animal Research Center of Chinese Academy of Medical Sciences. mutant Unknown Myh7bem1Blar 126925953 3 146115687 146139441 1 - by flanking markers 3 157472519 157518151 1 - by flanking markers 3 151105038 151150621 1 - by flanking markers 3 144076911 144122714 1 - by flanking markers RRID:RGD_126925949 126925952 SD-Myh7bem1Blar-/- The Myh7b knockout SD rats were generated using the CRISPR/Cas9 system targeting exon 2, resulting 7 bases deletion of exon 2 and generated a new termination codon TGA in exon 3. The heterzygous Myh7b+/- rats were crossed to generate littermate controls. The birth ratio of wild type (WT):Myh7b+/-:Myh7b-/- was approximately 1:2:1, indicating that Myh7b-/- did not cause fetal death. Beijing Laboratory Animal Research Center of Chinese Academy of Medical Sciences. mutant Unknown Myh7bem1Blar 126925953 3 146115687 146139441 1 - by flanking markers 3 157472519 157518151 1 - by flanking markers 3 151105038 151150621 1 - by flanking markers 3 144076911 144122714 1 - by flanking markers RRID:RGD_126925952 126925978 SD-Ercc6em1Cgen The CRISPR/Cas9 system was designed to introduce an in-frame amino acid substitution (R571X. CGA > TGA). A silent mutation (ACC to ACG) was also introduced to prevent the binding and re-cutting of the sequence by gRNA after HDR. Founder animals harboring the expected single-nucleotide substitution were bred to produce heterozygous and homozygous rats.The heterozygous rats had phenotypes similar to the wild type littermates. Key Laboratory of Neurological Function and Health, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China. mutant Unknown Ercc6em1Cgen 126925980 16 8024881 8091587 1 - by flanking markers 16 10699983 10770565 1 - by flanking markers 16 8734028 8804610 1 - by flanking markers 16 7764983 7835587 1 - by flanking markers RRID:RGD_126925978 126925992 SD-Cftrem1Ang The CRISPR/Cas9 system targeting at exon 12 to create deletion at codon F508 was injected to the male pronucleus of the fertalized one-cell stage embryos collected from Crl:SD. The donor DNA generated a codon deletion at F508 and the creation of one NdeI restriction site for sequencing identification. mutant Unknown Cftrem1Ang 126925993 4 43874852 44041870 1 - by flanking markers 4 42281040 42448571 1 - by flanking markers 4 42693263 42860679 1 - by flanking markers 4 46561269 46728759 1 - by flanking markers RRID:RGD_126925992 126925994 SD-Cftrem2Ang The CRISPR/Cas9 system targeting at exon 3 to create gene knock out was injected to the male pronucleus of the fertalized one-cell stage embryos collected from Crl:SD. The donor DNA generated a frameshift and the creation of one XbaI restriction site and a premature stop codon. Two knockout founders ( referred as MUKORAT8.3 and MUKORAT 6.4) exhibit no difference in phenotypes and were pooled for study. INSERM 1151 INEM Universit? de Paris Paris France. mutant Unknown Cftrem2Ang 126925995 4 43874852 44041870 1 - by flanking markers 4 42281040 42448571 1 - by flanking markers 4 42693263 42860679 1 - by flanking markers 4 46561269 46728759 1 - by flanking markers RRID:RGD_126925994 126928141 SD-F8em1Sage/Novo-Tg(ITGA2B-F8*)Mcwi This transgenic was produced by crossing the SD transgenic rat carrying Lentivirus constructs containing the 2bF8 vector [B-domain deleted human FVIII under control of ITGA2B (IIb) promoter] with an F8 knockout rat SD-F8em1Sage-/-/Novo (RGD:11531091). This transgenic rat strain expressed B-domain deleted human F8 under the control of ITGA2B promoter in the absence of rat F8 product. Blood Research Institute 8733 W Watertown Plank Road Milwaukee, WI 53226 transgenic Unknown F8em1Sage 11531096 RRID:RGD_126928141 126928146 ACI.Cg.-Cdkn1bem1Musc The CRISPR-Cas9 system targeted to exon 2 of the rat Cdkn1b was injected to zygotes derived from the Sprague-Dawley outbred rat strain. Two mutations with the highest potential impact on Cdkn1b function were transferred through the germline showing a 32-bp deletion (DEL-32, em1Musc) and a 65-bp deletion (DEL-65, em4Musc), both disrupting the open reading frame of the Cdkn1b gene. The selected mutations were breded to the ACI inbred strain for future study. This mutant strain ACI.Cg.-Cdkn1bem1Musc harbors 32-bp deletion of Cdkn1b exhibits same phenotype as the em4Musc with 65-bp deletion Transgenic and Gene Function Core, Medical University of South Carolina, Charleston, South Carolina, United States of America mutant Unknown Cdkn1bem1Musc 126928147 4 171841705 171846506 1 - by flanking markers 4 232962218 232967323 1 - by flanking markers 4 168689043 168694159 1 - by flanking markers 4 167760067 167765177 1 - by flanking markers RRID:RGD_126928146 126928150 ACI.Cg.-Cdkn1bem4Musc The CRISPR-Cas9 system targeted to exon 2 of the rat Cdkn1b was injected to zygotes derived from the Sprague-Dawley outbred rat strain. Two mutations with the highest potential impact on Cdkn1b function were transferred through the germline showing a 32-bp deletion (DEL-32, em1Musc) and a 65-bp deletion (DEL-65, em4Musc), both disrupting the open reading frame of the Cdkn1b gene. The selected mutations were breded to the ACI inbred strain for future study. This mutant strain ACI.Cg.-Cdkn1bem4Musc harbors 65-bp deletion of Cdkn1b exhibits same phenotype as the em1Musc with 32-bp deletion Transgenic and Gene Function Core, Medical University of South Carolina, Charleston, South Carolina, United States of America mutant Unknown Cdkn1bem4Musc 126928151 4 171841705 171846506 1 - by flanking markers 4 232962218 232967323 1 - by flanking markers 4 168689043 168694159 1 - by flanking markers 4 167760067 167765177 1 - by flanking markers RRID:RGD_126928150 127284837 GK/Wnsm The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. The GK line was established by repeated inbreeding from Wistar rats selected at the upper limit of normal distribution for glucose tolerance. Repeated selection of rats with tendency to lowest glucose tolerance resulted in clear-cut glucose intolerance after five generations. This GK/Wnsm colony was established at the University of Wales College of Medicine (Cardiff, UK) after received breeding pairs provided by Professor Y Goto (Tohoku University School of Medicine, Sendai, Japan). University of Wales College of Medicine (Cardiff, UK) inbred Unknown RRID:RGD_127284837 127284865 F344-Nppcem1Kyo This strain was established by injecting Zinc-finger nucleases (ZFNs) to F344/Stm pronuclear stage embryos. Selected ZFNs were designed to target exon 1 of rat Nppc, which encodes the N-terminus of natriuretic peptide precursor C (target sequence: CGAAGCCAAGCCCGGGACaccaccGAAGGTGGGTGCTGTCGCG; nucleotides 179 - 221, NC_005108.4). The injected F344/Stm embryos were transferred into the oviducts of pseudopregnant rats. Four lines of knockout strains were estaglished. This F344-Nppcem1Kyo strain ( delta 6) was deduced to generate a two a.a. deletion (a.a. 28 and 29, Pro and Pro, NP_446202, at nucleotides 198 - 203, NM_053750.1). National BioResource Project for the Rat in Japan mutant Unknown Nppcem1Kyo 127284866 9 85434254 85438454 1 - by flanking markers 9 93458753 93462953 1 - by flanking markers 9 93731436 93735636 1 - by flanking markers 9 87320051 87324251 1 - by flanking markers RRID:RGD_127284865 127284868 F344-Nppcem2Kyo This strain was established by injecting Zinc-finger nucleases (ZFNs) to F344/Stm pronuclear stage embryos. Selected ZFNs were designed to target exon 1 of rat Nppc, which encodes the N-terminus of natriuretic peptide precursor C (target sequence: CGAAGCCAAGCCCGGGACaccaccGAAGGTGGGTGCTGTCGCG; nucleotides 179 - 221, NC_005108.4). The injected F344/Stm embryos were transferred into the oviducts of pseudopregnant rats. Four lines of knockout strains were estaglished. This F344-Nppcem2Kyo strain ( delta 9) was deduced to generate one amino-acid substitution (a.a. 26, from Gly to Ala, NP_446202, at nucleotides 192 - 194, NM_053750.1) and a three amino-acid deletion (a.a. 27 - 29, Thr, Pro and Pro, NP_446202, at nucleotides 193 - 201, NM_053750.1), within the N-terminal portion of the full-length Nppc National BioResource Project for the Rat in Japan mutant Unknown Nppcem2Kyo 127284869 9 85434254 85438454 1 - by flanking markers 9 93458753 93462953 1 - by flanking markers 9 93731436 93735636 1 - by flanking markers 9 87320051 87324251 1 - by flanking markers RRID:RGD_127284868 127284870 F344-Nppcem3Kyo This strain was established by injecting Zinc-finger nucleases (ZFNs) to F344/Stm pronuclear stage embryos. Selected ZFNs were designed to target exon 1 of rat Nppc, which encodes the N-terminus of natriuretic peptide precursor C (target sequence: CGAAGCCAAGCCCGGGACaccaccGAAGGTGGGTGCTGTCGCG; nucleotides 179 - 221, NC_005108.4). The injected F344/Stm embryos were transferred into the oviducts of pseudopregnant rats. Four lines of knockout strains were estaglished. This F344-Nppcem3Kyo strain ( delta 11)was deduced to generated a frame shift and a premature stop codon (at nucleotides 275 - 277, NM_053750.1) National BioResource Project for the Rat in Japan mutant Unknown Nppcem3Kyo 127284871 9 85434254 85438454 1 - by flanking markers 9 93458753 93462953 1 - by flanking markers 9 93731436 93735636 1 - by flanking markers 9 87320051 87324251 1 - by flanking markers RRID:RGD_127284870 127284872 F344-Nppcem4Kyo This strain was established by injecting Zinc-finger nucleases (ZFNs) to F344/Stm pronuclear stage embryos. Selected ZFNs were designed to target exon 1 of rat Nppc, which encodes the N-terminus of natriuretic peptide precursor C (target sequence: CGAAGCCAAGCCCGGGACaccaccGAAGGTGGGTGCTGTCGCG; nucleotides 179 - 221, NC_005108.4). The injected F344/Stm embryos were transferred into the oviducts of pseudopregnant rats. Four lines of knockout strains were estaglished. This F344-Nppcem4Kyo strain ( delta 774) had a massive deletion within the Nppc gene that included the translation initiation site. Quantitative RT-PCR revealed that the expression of Nppc mRNA in the brain was drastically decreased in homozygous delta 774 mutant rats. National BioResource Project for the Rat in Japan mutant Unknown Nppcem4Kyo 127284873 9 85434254 85438454 1 - by flanking markers 9 93458753 93462953 1 - by flanking markers 9 93731436 93735636 1 - by flanking markers 9 87320051 87324251 1 - by flanking markers RRID:RGD_127284872 127284883 SD-Aqp4em1Hrt The transcription activator-like effector nuclease (TALEN)-mediated knockout approach was applied to generate Aqp4-deficient rats. The synthesized TALENs against the following sequences: (5′-CACAGCAGAGTTCCTGG-3′) for the sense strand and (5′-GGATCCCACGCTGAGCA-3′) for the antisense strand. The founder animal lacking three base pairs was crossed with wild-type rat to produced the F1 generration and the heterozygous offspring of F1 were corssed to produce mutant strains and confirmed by sequencing analysis of PCR products of modified genome region. Department of Anatomy and Histology, School of Basic Medical Sciences, Peking University, Beijing, China mutant Unknown Aqp4em1Hrt 127284884 18 6626313 6642766 1 - by flanking markers 18 6720759 6737703 1 - by flanking markers 18 6766009 6782757 1 - by flanking markers 18 6507903 6524558 1 - by flanking markers RRID:RGD_127284883 127285380 SD-Mir31em1Sage CRISPR/Cas9 system was used to introduce the gene knockout of Mir31 in the Sprague Dawley embryos. Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210; mutant Unknown RRID:RGD_127285380 127285404 SHR-Cfbem1Tja This strain was produced by injecting ZFNs targeting exon 6 of rat complement factor b (Cfb) (target sequence: CCCCTCGGGCTCCATGaatatcTACATGGTGCTGGATG),into SHR/NCrl rat embryos. The resulting mutation is a 19-bp deletion. Centre for Genomic and Experimental Medicine, MRC Institute for Genetics and Molecular Medicine, Edinburgh, United Kingdom mutant Unknown Cfbem1Tja 127285405 20 6616005 6621872 1 - by flanking markers 20 4536206 4542073 1 - by flanking markers 20 3970643 3976510 1 - by flanking markers RRID:RGD_127285404 127285409 SD-Abcc8em1Cgen TALEN system targeting the rat Abcc8 (sulfonylurea receptor 1, SUR1 ) gene was injected into Crl:CD(SD) embryos. This strain carries a 16-bp deletion corresponding to CCT CAC GGG GCT TCTG compared with wild-type rats is homozygous. No Abcc8 protein was detected in the liver and muscle tissues. Cyagen Biosciences Inc., Guangzhou, China mutant Unknown Abcc8em1Cgen 127285598 1 96622574 96703723 1 - by flanking markers 1 103194473 103275508 1 - by flanking markers 1 102110708 102191287 1 - by flanking markers 1 96598663 96679495 1 - by flanking markers RRID:RGD_127285409 127285661 SD-Adgrl3em1Huyc The CRISPR/Cas9 system was used to to delete exon 3 of the rat Adgrl3 (Lphn3). Two sgRNAs targeting the sequences flanking exon 3 (GTCCCTTGCCAGTACATCTC and CCTAGTGTTGTGTTCTGCTA),Cas9 mRNA with the CRISPR/Cas9 reagents was injected into fertilized eggs. Genotyping of founder rats was confirmed by PCR genotyping using three primers: 1. AAAGGGTCATAGCATCCGGC, 2. CTAACGTGGCTTTTTGTCTTCT, and 3. GCTCGACAGACAGTGTGGAT. The WT band occurs at ~320 bp and KO band at ~452 bp. Department of Pediatrics, University of Cincinnati College of Medicine, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH mutant Unknown Adgrl3em1Huyc 127285662 14 28385112 28854677 1 - by flanking markers 14 28183727 29040121 1 - by flanking markers 14 28362176 29226085 1 - by flanking markers 14 26336320 27104060 1 - by flanking markers RRID:RGD_127285661 127285810 SD-Trpa1em1Gne This Trpa1-deleted Sprague Dawley strain was generated by using CRISPR/Cas9. Rats harboring a 7282 bp deletion spanning Trpa1 exons 19 through 24, corresponding to genomic position RGSC 6.0/rn6 chr5:3,818,620-3,825,901 were identified. Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080 USA mutant Unknown Trpa1em1Gne 127285812 5 3531163 3584401 1 - by flanking markers 5 3764339 3818781 1 - by flanking markers 5 3783247 3836485 1 - by flanking markers 5 4379999 4433243 1 - by flanking markers RRID:RGD_127285810 127338473 WM/Nem This Strain was from the National Institute of Genetics., Mishima, Japan to the research institute of Environmental Medicine, Nagoya University. The research institute of Environmental Medicine, Nagoya University. inbred Unknown RRID:RGD_127338473 127338474 BDIX/Nem This strain was maintained in Germany and was transferred to Japan by Dr. Tanaka of Aichi Cancer Center. Thereafter, this strain was transferred to Research Institute of Environmental Medicine, Nagoya University in 1973 inbred Unknown RRID:RGD_127338474 127345097 SD-Muc1em1Cgen The Muc1 knock out Sprague Dawley rats were produced by targeted gene mutation at rat Muc1 gene. The deletion was made by microinjection of TALENs and located in the exon 1 of rat Muc1 gene (Gen Bank: NM_012602.1). Genotyping was performed by PCR of tail DNA using primers specific for the rat MUC1 gene with forward primer 5′-CTAGCAAGCCTAAAAGGTGAGAGGT-3′ and reverse primer 5′-ACGAAGAGCATTTGCCTACTC-3′, followed by DNA sequencing analysis. Cyagen Biosciences Inc., Guangzhou, China mutant Unknown Muc1em1Cgen 127345099 2 181399482 181403640 1 - by flanking markers 2 207957206 207962396 1 - by flanking markers 2 188543137 188547874 1 - by flanking markers 2 174635559 174640738 1 - by flanking markers RRID:RGD_127345097 127345123 F344-Angptl8em1Kyo-/- This line #1 Angptl8 knock out (KO) rats were generated using the CRISPR/Cas9 system containing two guide RNAs (gRNAs) targeting exons 2 and 3 in the rat Angptl8 gene. A mixture of transcribed Cas9 and gRNAs was microinjected into F344/Stm rat zygotes [National BioResource Project rat number: 0140) provided by the National BioResource Project for the Rat in Japan. Two lines of rats heterozygous for Angptl8 (lines #1 and #2). Male and female Het rats were intercrossed to obtain homozygous Angptl8 KO rats. Rats were genotyped by PCR with the following primers, 5'-CATCTGTTGAGCAGGCAGAA-3' (sense) and 5'-GTTCAGTGGTGGCTTCCTTC-3' (antisense) for line #1. A 7-bp deletion mutation was identified in line #1. Medical Innovation Center Kyoto University Graduate School of Medicine, Kyoto, Japan, National BioResource Project for the Rat in Japan mutant Unknown Angptl8em1Kyo 127345127 8 20948070 20950087 1 - by flanking markers 8 22910979 22913005 1 - by flanking markers 8 22855495 22858565 1 - by flanking markers 8 20376462 20378488 1 - by flanking markers RRID:RGD_127345123 127345124 F344-Angptl8em1Kyo+/- This line #1 Angptl8 heterozygous rats were generated using the CRISPR/Cas9 system containing two guide RNAs (gRNAs) targeting exons 2 and 3 in the rat Angptl8 gene. A mixture of transcribed Cas9 and gRNAs was microinjected into F344/Stm rat zygotes [National BioResource Project rat number: 0140) provided by the National BioResource Project for the Rat in Japan. Two lines of rats heterozygous for Angptl8 (lines #1 and #2). Male and female Het rats were intercrossed to obtain homozygous Angptl8 KO rats. Rats were genotyped by PCR with the following primers, 5'-CATCTGTTGAGCAGGCAGAA-3'(sense) and 5'-GTTCAGTGGTGGCTTCCTTC-3' (antisense) for line #1. A 7-bp deletion mutation was identified in line #1. Medical Innovation Center Kyoto University Graduate School of Medicine, Kyoto, Japan, National BioResource Project for the Rat in Japan mutant Unknown Angptl8em1Kyo 127345127 8 20948070 20950087 1 - by flanking markers 8 22910979 22913005 1 - by flanking markers 8 22855495 22858565 1 - by flanking markers 8 20376462 20378488 1 - by flanking markers RRID:RGD_127345124 127345125 F344-Angptl8em2Kyo-/- This line #2 Angptl8 knock out (KO) rats were generated using the CRISPR/Cas9 system containing two guide RNAs (gRNAs) targeting exons 2 and 3 in the rat Angptl8 gene. A mixture of transcribed Cas9 and gRNAs was microinjected into F344/Stm rat zygotes [National BioResource Project rat number: 0140) provided by the National BioResource Project for the Rat in Japan. Two lines of rats heterozygous for Angptl8 (lines #1 and #2). Male and female Het rats were intercrossed to obtain homozygous Angptl8 KO rats. Rats were genotyped by PCR with the following primers5'-GGGTGAGCAAAGCTGACCTA-3' (sense) and 5'-GAGTAAACCCACCAGGCTCA-3' (antisense) for line #2. A 980-bp deletion in the ANGPTL8 gene was identified in line # 2, resulting in a premature termination codon. Medical Innovation Center Kyoto University Graduate School of Medicine, Kyoto, Japan, National BioResource Project for the Rat in Japan mutant Unknown Angptl8em2Kyo 127345128 RRID:RGD_127345125 127345126 F344-Angptl8em2Kyo+/- This line #2 Angptl8 heterozygous rats were generated using the CRISPR/Cas9 system containing two guide RNAs (gRNAs) targeting exons 2 and 3 in the rat Angptl8 gene. A mixture of transcribed Cas9 and gRNAs was microinjected into F344/Stm rat zygotes [National BioResource Project rat number: 0140) provided by the National BioResource Project for the Rat in Japan. Two lines of rats heterozygous for Angptl8 (lines #1 and #2). Male and female Het rats were intercrossed to obtain homozygous Angptl8 KO rats. Rats were genotyped by PCR with the following primers5'-GGGTGAGCAAAGCTGACCTA-3' (sense) and 5'-GAGTAAACCCACCAGGCTCA-3' (antisense) for line #2. A 980-bp deletion in the ANGPTL8 gene was identified in line # 2, resulting in a premature termination codon. Medical Innovation Center Kyoto University Graduate School of Medicine, Kyoto, Japan, National BioResource Project for the Rat in Japan mutant Unknown Angptl8em2Kyo 127345128 RRID:RGD_127345126 149735334 SD-Wfs1em1Ptsn Rat Wfs1 exon 5-specific zinc-finger nucleases (ZNFs) and microinjection-ready mRNA were injected to embryos harvested from female Sprague-Dawley rats (Crl: CD(SD) )rats. Thereafter, microinjected egg cells were transferred to the oviduct of pseudopregnant Sprague-Dawley recipients.Three different Wfs1 mutant rat lines were created: Wfs1em1 ( Wfs1-ex5-KO232), Wfs1em2 (Wfs1-ex5-KO266) and Wfs1em3 (Wfs1-ex5-INS244). Wfs1em1 rats carry a 184 bp deletion, resulting 27 amino acids deletion in exon 5 (aa212-238) and a new GCC codon(alanine). Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, mutant Unknown Wfs1em1Ptsn 149735335 14 79379680 79404003 1 - by flanking markers 14 78606172 78630689 1 - by flanking markers 14 78640707 78665224 1 - by flanking markers 14 73810478 73834993 1 - by flanking markers RRID:RGD_149735334 149735336 SD-Wfs1em2Ptsn Rat Wfs1 exon 5-specific zinc-finger nucleases (ZNFs) and microinjection-ready mRNA were injected to embryos harvested from female Sprague-Dawley rats (Crl: CD(SD) )rats. Thereafter, microinjected egg cells were transferred to the oviduct of pseudopregnant Sprague-Dawley recipients.Three different Wfs1 mutant rat lines were created: Wfs1em1 ( Wfs1-ex5-KO232), Wfs1em2 (Wfs1-ex5-KO266) and Wfs1em3 (Wfs1-ex5-INS244). Wfs1em2 rats carry a 27 amino acids deletion in exon 5 (aa212-238). Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, mutant Unknown Wfs1em2Ptsn 149735337 14 79379680 79404003 1 - by flanking markers 14 78606172 78630689 1 - by flanking markers 14 78640707 78665224 1 - by flanking markers 14 73810478 73834993 1 - by flanking markers RRID:RGD_149735336 149735338 SD-Wfs1em3Ptsn Rat Wfs1 exon 5-specific zinc-finger nucleases (ZNFs) and microinjection-ready mRNA were injected to embryos harvested from female Sprague-Dawley rats (Crl: CD(SD) )rats. Thereafter, microinjected egg cells were transferred to the oviduct of pseudopregnant Sprague-Dawley recipients.Three different Wfs1 mutant rat lines were created: Wfs1em1 ( Wfs1-ex5-KO232), Wfs1em2 (Wfs1-ex5-KO266) and Wfs1em3 (Wfs1-ex5-INS244). Wfs1em3 rats carry a substitution in exon 5 of the Wfs1 gene, which is predicted to result in a substitution of LQK (aa 224-226) into YCMNTI in the WFS1 protein. Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, mutant Unknown Wfs1em3Ptsn 149735339 14 79379680 79404003 1 - by flanking markers 14 78606172 78630689 1 - by flanking markers 14 78640707 78665224 1 - by flanking markers 14 73810478 73834993 1 - by flanking markers RRID:RGD_149735338 149735356 SD-Tg(Wnt1-cre/ERT2)Appsc The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Wnt1 gene linked by 2A peptide. This model is used to lineage tracing of neural crest cells by tissue specific expression of creERT2 Available at Rat Resource and Research Center transgenic Live Animals (as of 2021-07-19) RRID:RGD_149735356 149735357 SD-Tg(PDGFB-cre/ERT2)Appsc The 'docking site ready (DSR)' rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. With integrase, these TARGAT/DSR rats are used as embryo donors. TARGATT rat embryos will be microinjected with a mixture of TARGATT Cre DNA constructs containing human PDGFB promoter, a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The brain tissue-specific expression of a CreERT2 is also tamoxifen-dependent. Available at Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2021-07-19) RRID:RGD_149735357 149735358 SD-Tg(Olfr16-cre/ERT2)Appsc The 'docking site ready (DSR)' rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. With integrase, these TARGAT/DSR rats are used as embryo donors. TARGATT rat embryos will be microinjected with a mixture of TARGATT Cre DNA constructs containing mouse Olfr16 (MOR23) promoter, a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The Olfactory sensory neuronal lineage tissue-specific expression of a CreERT2 is also tamoxifen-dependent. Available at Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2021-07-19) RRID:RGD_149735358 149735359 SD-Tg(Mnx1-cre/ERT2)Appsc The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Mnx1 (HB9) gene linked by 2A peptide. This model is used to lineage tracing of motor neurons by tissue specific expression of creERT2 available at Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryorecovery (as of 2021-07-19) RRID:RGD_149735359 149735361 SD-Tg(Drd1-cre/ERT2)Appsc The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Drd1 (Drd1a) gene linked by 2A peptide. This model is used to lineage tracing of dopamine D1 receptor expressing neurons Available at Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryorecovery (as of 2021-07-19) RRID:RGD_149735361 149735362 SD-Tg(Gad1-cre/ERT2)Appsc The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Gad1 (Gad67) gene linked by 2A peptide. This model is used to lineage tracing of glutamate decarboxylase 1 expressing cells such as GABAergic neurons, islet cells and spermatocytes. Available at Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryorecovery (as of 2021-07-19) RRID:RGD_149735362 149735363 SD-Tg(GFAP-cre/ERT2)Appsc The 'docking site ready (DSR)' rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. With integrase, these TARGAT/DSR rats are used as embryo donors. TARGATT rat embryos will be microinjected with a mixture of TARGATT Cre DNA constructs containing human GFAP promoter, a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The astrocyte tissue-specific expression of a CreERT2 is also tamoxifen-dependent. Available at Rat Resource and Research Center transgenic Live Animals (as of 2021-07-19) RRID:RGD_149735363 149735364 SD-Tg(Tie2-cre/ERT2)Appsc The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Tie2 gene linked by 2A peptide. This model is used to lineage tracing of vascular endothelial cells by tissue specific expression of creERT2 Available at Rat Resource and Research Center transgenic Live Animals (as of 2021-07-19) RRID:RGD_149735364 149735365 SD-Tg(SMHC-cre/ERT2)Appsc The 'docking site ready (DSR)' rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. With integrase, these TARGAT/DSR rats are used as embryo donors. TARGATT rat embryos will be microinjected with a mixture of TARGATT Cre DNA constructs containing rabbit smooth muscle myosin heavy chain (SMHC) gene promoter, a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The Olfactory sensory neuronal lineage tissue-specific expression of a CreERT2 is also tamoxifen-dependent. Available at Rat Resource and Research Center transgenic Live Animals (as of 2021-07-19) RRID:RGD_149735365 149735366 SD-Tg(CAG-GFP-LacZ)Appsc A transgenic line carrying random insertion of transgene cassette CAG-LSL-GFP-LacZ (LSL: loxp-Stop-Loxp). It is used as a Cre reporter/test line expressing GFP and lacZ. Used as lineage tracing tool rat line by mating with tissue specific cre or cre/ERT2 line Available at Rat Resource and Research Center transgenic Unknown RRID:RGD_149735366 149735371 SHR-C3em1Kyo ZFN constructs specific for the rat C3 gene were designed to target bases 1803-1841 (NCBI reference sequence: NM_016994) of C3 (target sequence: cagggggcccgagtgggctagtggctgtggacaagggg) by Sigma-Aldrich (Tokyo, Japan). The ZFN systems were injected into the pronucleus of SHR/Izm embryos. The DNA of 10 day old pups was extracted and screened for ZFN-induced mutations. Briefly, DNA extracted from ear tissue was amplified using primers flanking the target sequence (forward primer: 5'-ACTCTTCCCTGTCTTGCGTC-3'; reverse primer: 5'-AATAGAGGCCACCAATGCAC-3'). This mutant revealed a 9-base frameshift deletion of bases 1815-1824 (ggctagtgg). National BioResource Project for the Rat in Japan advanced_intercross_line Cryopreserved Embryo (as of 2021-07-20) C3em1Kyo 149735372 RRID:RGD_149735371 149735516 LL/MavRrrcAek Lyon hypotensive In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed unrestrained conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. The strain from Rat Resource & Research Center was maintained at Department of Pharmacology, University of Iowa inbred Unknown (as of 2021-07-21) RRID:RGD_149735516 149735517 LEXF10A/StmMcwi These are re-derived rats of LEXF10A/Stm now maintained at Medical College of Wisconsin. The parent strain was derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_149735517 149735518 HXB4/IpcvMcwi These are re-derived rats of HXB4/Ipcv now maintained at Medical College of Wisconsin. The parent strain was derived from founder strains SHR/OlaIpcv and BN-Lx/Cub RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_149735518 149735519 HXB31/IpcvMcwi These are re-derived rats of HXB31/Ipcv now maintained at Medical College of Wisconsin. The parent strain was derived from founder strains SHR/OlaIpcv and BN-Lx/Cub RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_149735519 149735520 HXB2/IpcvMcwi These are re-derived rats of HXB2/Ipcv now maintained at Medical College of Wisconsin. The parent strain was derived from founder strains SHR/OlaIpcv and BN-Lx/Cub. RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_149735520 149735521 HXB20/IpcvMcwi These are re-derived rats of HXB20/Ipcv now maintained at Medical College of Wisconsin. The parent strain wasDerived from founder strains SHR/OlaIpcv and BN-Lx/Cub RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_149735521 149735530 BXH2/CubMcwi These are re-derived rats of BXH2/Cub now maintained at Medical College of Wisconsin. The parent strain was derived from founder strains BN-Lx/Cub and SHR/OlaIpcv RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_149735530 149735533 BXH3/CubMcwi These are re-derived rats of BXH3/Cub now maintained at Medical College of Wisconsin. The parent strain was derived from founder strains BN-Lx/Cub and SHR/OlaIpcv. RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_149735533 149735557 LE-Tg(Pdyn-cre)2-9Koba This strain was produced by injecting a modified BAC, in which a Cre recombinase was inserted into the third exon of the rat Pdyn gene, into rat zygotes (Iar:Long-Evans, RGD:18337282). This strain is a transgenic rat that expresses Cre recombinase under the control of the Pdyn gene. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2021-07-22) RRID:RGD_149735557 149735558 F344.LEA-Ugl/Okt A congenic strain in which the ugl locus of LEA/Tohm rats was introduced into F344/NSlc rats. "This strain is homozygous for the ugl locus, which contains a 13 bp deletion in the Ctns gene.Cystinosis model rat. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2021-07-22) RRID:RGD_149735558 149735559 F344.LEA-Idao/Okt A congenic strain in which the Idao locus of LEA/Tohm rats was introduced into F344/NSlc rats. "This strain is homozygous for the Idao locus, which contains a 54.1 kb deletion in the Dao gene. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2021-07-22) RRID:RGD_149735559 149735560 LE-Gad1em15Yyan Knockout rats carry a 291 bp deletion, including exon-6 of Gad1 gene using the CRISPR/Cas9. Glutamate decarboxylase (GAD; there are two isoforms, GAD65 and GAD67) is an enzyme that synthesizes the neurotransmitter GABA. In this strain, the Gad1 gene encoding GAD67 was knocked out. In homozygous rats, low body weight at 3 weeks and impaired spatial learning memory were observed. Some homozygous rats die as juveniles. This strain is maintained in heterozygotes. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2021-07-22) Gad1em15Yyan 149735561 3 52789370 52830038 1 - by flanking markers 3 63479963 63519879 1 - by flanking markers 3 56861440 56902139 1 - by flanking markers 3 55369704 55410335 1 - by flanking markers RRID:RGD_149735560 149735562 LE-Gad2em24Yyan Knockout rats in which the Gad2 gene was disrupted using the TALEN. In this strain, the Gad2 gene encoding GAD65 was knocked out. In homozygous rats, a high rate of epileptic seizures was observed at 2 to 3 weeks of age. National BioResource Project for the Rat in Japan mutant Cryopreserved Sperm (as of 2021-07-22) Gad2em24Yyan 149735563 17 96259430 96321857 1 - by flanking markers 17 90851699 90914893 1 - by flanking markers 17 89171576 89234770 1 - by flanking markers 17 84763630 84826155 1 - by flanking markers RRID:RGD_149735562 149735570 F344-Atg16l1em8Rrrc CRISPR-Cas9-mediated knock-in of a single base pair polymorphism of guanine to alanine in exon 10, resulting in a threonine to alanine substitution at amino acid position 299 in the rat. Mimics the same nucleotide substitution for the threonine to alanine substitution at amino acid position 300 in humans (T300A), Homozygosity for this allele is embryonic lethal. RRRC mutant Live Animals (as of 2021-07-23) Inflammatory Bowel Disease, autophagy Atg16l1em8Rrrc 149735571 RRID:RGD_149735570 149735895 LEW-Tg(Col2a1-luc,-mCherry)RmptRrrc Random insertion of transgene consisting of firefly luciferase-T2A-mCherry driven by regulatory elements of rat Col2a1, for conditional expression in chondrogenic cells. Both reporters are expressed by chondrogenic cells, leading to bioluminescence within regions of active chondrogenesis upon injecting rats with D-luciferin Rat Resource and Research Center transgenic Unknown Skeletal Regenerative Medicine RRID:RRRC_00942 149735896 LEW-Tg(Col2a1-luc,-mCherry)Rmpt Random insertion of transgene consisting of firefly luciferase-T2A-mCherry driven by regulatory elements of rat Col2a1, for conditional expression in chondrogenic cells. Both reporters are expressed by chondrogenic cells, leading to bioluminescence within regions of active chondrogenesis upon injecting rats with D-luciferin This transgenic was created by Dr. Ryan Porter at University of Arkansas for Medical Sciences. Now available at Rat Resource and Research Center transgenic Unknown Skeletal Regenerative Medicine RRID:RGD_149735896 149735897 F344-Cacna1agry/Okym This strain is derived from GRY/Idr (GRY/Idr has the M251K mutation in the Cacna1a gene) provided from NBRP-Rat. GRY/Idr was backcrossed to F344/NSlc. National BioResource Project for the Rat in Japan congenic Cryopreserved Sperm (as of 2021-07-29) Neurobiology RRID:RGD_149735897 149735898 SD-Myh7bem1Blar+/+ This is the homozygous wild type littermate from crossing of heterozygous SD-Myh7b mutants. The Myh7b knockout SD rats were generated using the CRISPR/Cas9 system targeting exon 2, resulting 7 bases deletion of exon 2 and generated a new termination codon TGA in exon 3. The heterzygous Myh7b+/- rats were crossed to generate littermate controls. The birth ratio of wild type (WT):Myh7b+/-:Myh7b-/- was approximately 1:2:1, indicating that Myh7b-/- did not cause fetal death. Beijing Laboratory Animal Research Center of Chinese Academy of Medical Sciences. mutant Unknown RRID:RGD_149735898 149735906 RCCHan:WIST Wistar Hannover rats are derived from the Han:WIST strain from the Zentral Institut fur Versuchstierzucht (ZfV) (Hannover, Germany). In 1989, 156 pairs were introduced from ZfV to the Institute for Biomedical Research (IBM) in Switzerland (IBM underwent a structural change [name change] to BRL Ltd. and RCC Ltd.) outbred Unknown RRID:RGD_149735906 150340617 SHRSP.SHR-(rs197197017 -rs198445122)/Utx A congenic strain made by introducing B2 fragment (a segment of chromosome 1, 154.7 Mb - 203 Mb) from SHR/Utx into SHRSP/BbbUtx.The B2 fragment contains wild-type Stim1 as confirmed by sequencing. University of Texas, Houston, TX congenic Unknown 1 148969064 186536846 1 - by flanking markers 1 163213339 205713847 1 - by flanking markers 1 156969388 198720287 1 - by flanking markers RRID:RGD_150340617 150340629 SS-Tgfb1em3Mcwi+/+ SS-Tgfb1em3Mcwi+/Tgfb1em3Mcwi+ ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed to produce homozygous wild type and heterozygous mutant littermates. PhysGen Knockouts mutant Unknown RRID:RGD_150340629 150404267 LEW-Myo15aci2/Ztm LEW/Ztm-ci2 rat is an animal model for syndromal deafness that arose from a spontaneous mutation. Base substitution (T->C) in exon 56 of Myo15, leading to an amino acid exchange from leucine (Leu) to proline (Pro) within the carboxy-terminal MyTH4 domain in the proteins' tail region. Institute of Laboratory Animal Science, Hannover Medical School, Hannover, Germany mutant Unknown Myo15aci2 150404269 10 46742535 46798928 1 - by flanking markers 10 46595676 46660835 1 - by flanking markers 10 46840098 46897362 1 - by flanking markers 10 45277619 45335953 1 - by flanking markers RRID:RGD_150404267 150429598 SS-Vwfem4Mcwi The rat strain was created via CRISPR/Cas9 targeting the VWF gene in DahlSS/Mcw (SS/JrHsdMcwi ) rat embryos. The resulting rat strain has a 13bp deletion in the untranslated region of Exon 52 of the VWF gene (g.158491511 - 158491523 on chromosome 4, Assembly: mRatBN7.2) The 13-bp deletion happens to be in the region where the polyadenylation signal resides (AAUAAA). The resulting mRNA is not polyadenylated and has trouble with transport from the nucleus to the cytoplasm. The result is a phenotype that is similar to a Type I von Willebrand Disease, being a partial quantitative deficiency of the circulating VWF protein. Some mRNA must make it through to translation, because low levels of VWF protein are detectable via ELISA (<10%). Both homozygous pairs and heterozygous pairs were used for breeding. Rat Genetic Models, through Versiti Blood Research Institute mutant Unknown Type I von Willebrand Disease Vwfem4Mcwi 150429599 4 161723415 161854766 1 - by flanking markers 4 225098521 225229257 1 - by flanking markers 4 158085059 158219525 1 - by flanking markers 4 158360152 158491539 1 - by flanking markers RRID:RGD_150429598 150429601 MWF.SHR-(D6Rat1-D6Rat30)/Rkb The congenic MWF.SHR-(D6Rat1-D6Rat30)/Rkb was generated by transfer of different nested SHR/FubRkb segments onto the MWF/FubRkb background. For this procedure, male and female rats of the MWF-6SHR (RGD:1641831) breeding, that were homozygous for all MWF chromosomes except RNO6 and heterozygous for RNO6, were intercrossed. Eight congenics were generated. Freie Universitdt Berlin, Berlin, Germany congenic Unknown 6 48631043 144152572 1 - by flanking markers 6 58374821 153672040 1 - by flanking markers 6 49695264 144745573 1 - by flanking markers 6 47370564 137801795 1 - by flanking markers RRID:RGD_150429601 150429602 MWF.SHR-(D6Rat1-D6Rat106)/Rkb The congenic MWF.SHR-(D6Rat1-D6Rat106)/Rkb was generated by transfer of different nested SHR/FubRkb segments onto the MWF/FubRkb background. For this procedure, male and female rats of the MWF-6SHR (RGD:1641831) breeding, that were homozygous for all MWF chromosomes except RNO6 and heterozygous for RNO6, were intercrossed. Eight congenics were generated. Freie Universitdt Berlin, Berlin, Germany congenic Unknown 6 68036028 144152572 1 - by flanking markers 6 78348236 153672040 1 - by flanking markers 6 68781170 144745573 1 - by flanking markers 6 65531555 137801795 1 - by flanking markers RRID:RGD_150429602 150429603 MWF.SHR-(D6Rat1-D6Mit8)/Rkb The congenic MWF.SHR-(D6Rat1-D6Mit8)/Rkb was generated by transfer of different nested SHR/FubRkb segments onto the MWF/FubRkb background. For this procedure, male and female rats of the MWF-6SHR (RGD:1641831) breeding, that were homozygous for all MWF chromosomes except RNO6 and heterozygous for RNO6, were intercrossed. Eight congenics were generated. Freie Universitdt Berlin, Berlin, Germany congenic Unknown 6 97561873 144152572 1 - by flanking markers 6 107370981 153672040 1 - by flanking markers 6 97949772 144745573 1 - by flanking markers 6 93701310 137801795 1 - by flanking markers RRID:RGD_150429603 150429604 MWF.SHR-(D6Rat1-D6Rat121)/Rkb The congenic MWF.SHR-(D6Rat1-D6Rat121)/Rkb was generated by transfer of different nested SHR/FubRkb segments onto the MWF/FubRkb background. For this procedure, male and female rats of the MWF-6SHR (RGD:1641831) breeding, that were homozygous for all MWF chromosomes except RNO6 and heterozygous for RNO6, were intercrossed. Eight congenics were generated. Freie Universitdt Berlin, Berlin, Germany congenic Unknown 6 99651951 144152572 1 - by flanking markers 6 109506414 153672040 1 - by flanking markers 6 100120078 144745573 1 - by flanking markers 6 95760211 137801795 1 - by flanking markers RRID:RGD_150429604 150429605 MWF.SHR-(D6Rat1-D6Mgh4)/Rkb The congenic MWF.SHR-(D6Rat1-D6Mgh4)/Rkb was generated by transfer of different nested SHR/FubRkb segments onto the MWF/FubRkb background. For this procedure, male and female rats of the MWF-6SHR (RGD:1641831) breeding, that were homozygous for all MWF chromosomes except RNO6 and heterozygous for RNO6, were intercrossed. Eight congenics were generated. Freie Universitdt Berlin, Berlin, Germany congenic Unknown 6 108503674 144152572 1 - by flanking markers 6 117391806 153672040 1 - by flanking markers 6 108154445 144745573 1 - by flanking markers 6 104085867 137801795 1 - by flanking markers RRID:RGD_150429605 150429606 MWF.SHR-(D6Rat1-D6Rat81)/Rkb The congenic MWF.SHR-(D6Rat1-D6Rat81)/Rkb was generated by transfer of different nested SHR/FubRkb segments onto the MWF/FubRkb background. For this procedure, male and female rats of the MWF-6SHR (RGD:1641831) breeding, that were homozygous for all MWF chromosomes except RNO6 and heterozygous for RNO6, were intercrossed. Eight congenics were generated. Freie Universitdt Berlin, Berlin, Germany congenic Unknown 6 111967597 144152572 1 - by flanking markers 6 120994890 153672040 1 - by flanking markers 6 111715478 144745573 1 - by flanking markers 6 107351142 137801795 1 - by flanking markers RRID:RGD_150429606 150429607 MWF.SHR-(D6Rat1-D6Rat115)/Rkb The congenic MWF.SHR-(D6Rat1-D6Rat115)/Rkb was generated by transfer of different nested SHR/FubRkb segments onto the MWF/FubRkb background. For this procedure, male and female rats of the MWF-6SHR (RGD:1641831) breeding, that were homozygous for all MWF chromosomes except RNO6 and heterozygous for RNO6, were intercrossed. Eight congenics were generated. Freie Universitdt Berlin, Berlin, Germany congenic Unknown 6 116550201 144152572 1 - by flanking markers 6 125802476 153672040 1 - by flanking markers 6 116576030 144745573 1 - by flanking markers 6 111837996 137801795 1 - by flanking markers RRID:RGD_150429607 150429608 MWF.SHR-(D6Rat1-D6Rat184)/Rkb The congenic MWF.SHR-(D6Rat1-D6Rat184)/Rkb was generated by transfer of different nested SHR/FubRkb segments onto the MWF/FubRkb background. For this procedure, male and female rats of the MWF-6SHR (RGD:1641831) breeding, that were homozygous for all MWF chromosomes except RNO6 and heterozygous for RNO6, were intercrossed. Eight congenics were generated. Freie Universitdt Berlin, Berlin, Germany congenic Unknown 6 121381065 144152572 1 - by flanking markers 6 130448688 153672040 1 - by flanking markers 6 121224054 144745573 1 - by flanking markers 6 116506292 137801795 1 - by flanking markers RRID:RGD_150429608 150429614 FHH-Tg(CAG-Add3)McwiRoman A full-length rat wild type Add3 cDNA obtained from an expression plasmid pCMV6-entry-Add3 purchased from Origene (Rockville, MD) was inserted in a sleeping beauty transposon vector. The expression of wild type ADD3 in the transposon vector was driven by a CAG promoter. The construct was injected into the pronucleus ofoocytes collected from female FHH/EurMcwi rats along with SB100 transposase mRNA. A single-transgene insertion was identified on chromosome 10, which is located .64 kbp away from the protein shisa-6 homolog precursor at its 59 end and .360 kbp away from the phosphoinositide-interacting protein at the 3 prime end. Heterozygous founders were intercrossed to derive a homozygous transgenic line that was used for studies. Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi transgenic Unknown Add3 2043 RRID:RGD_150429614 150429615 SD-Add3em1Mcwi/ Roman ZFN system was used to Knock out the rat Add3 gene of Crl:SD rat embryos.The ZFN mRNA was injected into the pronucleus of fertilized SpragueDawley embryos and transferred to the oviduct of pseudopregnant females. PCR genotyping of tail biopsies confirmed a 14-bp deletion using forward primer 5'-GCCCCCATGAGTCACTACAC-3' and reverse primer 5'-GCTACAGGAAGCATCTCCTGTG-3'. Founders with Add3 deletion were backcrossed to the parental strain to generate heterozygous F1 rats. Heterozygous F1 siblings were then intercrossed to derive a homozygous KO line used Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi mutant Unknown (as of 2021-09-09) Add3em1Mcwi 150429617 1 259347673 259455407 1 - by flanking markers 1 281267424 281375203 1 - by flanking markers 1 273854195 273961982 1 - by flanking markers 1 252147341 252255126 1 - by flanking markers RRID:RGD_150429615 150429618 FHH-Chr 1BN-Add3em2Mcwi /Roman ZFN system was used to Knock out the rat Add3 gene of FHH-Chr 1BN/Mcwi rat embryos.The ZFN mRNA was injected into the pronucleus of fertilized FHH-Chr 1BN/Mcwi embryos and transferred to the oviduct of pseudopregnant females. PCR genotyping of tail biopsies confirmed a 68-bp deletion using forward primer 5'-GCCCCCATGAGTCACTACAC-3' and reverse primer 5'-GCTACAGGAAGCATCTCCTGTG-3'. Founders with Add3 deletion were backcrossed to the parental strain to generate heterozygous F1 rats. Heterozygous F1 siblings were then intercrossed to derive a homozygous KO line used Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi mutant Unknown Add3em2Mcwi 150429619 1 259347673 259455407 1 - by flanking markers 1 281267424 281375203 1 - by flanking markers 1 273854195 273961982 1 - by flanking markers 1 252147341 252255126 1 - by flanking markers RRID:RGD_150429618 150429634 F344 -Aspaem34Kyo Hcn1em1Kyo F344-Aspaem34Kyo (RGD:11564349) and F344-Hcn1em1Kyo (RGD:38676253) rats from the National BioResource Project-Rat were intercrossed to produce F1 hybrids and then to obtain F2 progeny. Rats homozygous for both Aspa and Hcn1 knockout alleles were selected from among F2 progeny and were used to generate the F344-Aspaem34Kyo/Hcn1em1Kyo double- knockout strain. Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan mutant Unknown Aspaem34Kyo|Hcn1em1Kyo 11564348|150429632 10;2 60178509;49525949 60199207;49939066 1 - by flanking markers;1 - by flanking markers 10;2 59578788;68473431 59627450;68874494 1 - by flanking markers;1 - by flanking markers 10;2 59839693;50099576 59888244;50499799 1 - by flanking markers;1 - by flanking markers 2;10 49495771;57891704 49899702;57945267 1 - by flanking markers;1 - by flanking markers RRID:RGD_150429634 150429707 SD-Cyp2c11em1Nju CRISPR/Cas9 system containing two pairs of single guide RNA (sgRNA) primers: sgRNA1 (forward primer: 59-GCTACTG- TAACTGACATGTT-39; reverse primer: 59-AACATGTCAGTTACAGTAGC- 39) and sgRNA2 (forward primer: 59-TCAAGGGTAAACTCAGACTG-39; reverse primer: 59-CAGTCTGAGTTTACCCTTGA-39), was injected to Sprague-Dawley rat one-cell embryos. The F0 pups were screened by genomic DNA sequencing to identify heterozygous CYP2C11+/2 founders.This mutant strain carries a two base pairs (GT) insertion into exon 6 of CYP2C11 and resulting in the knockout allele. mutant Unknown Cyp2c11em1Nju 150429708 1 243281320 243320945 1 - by flanking markers 1 265418158 265454574 1 - by flanking markers 1 257676172 258004428 1 - by flanking markers 1 236762719 236799069 1 - by flanking markers RRID:RGD_150429707 150429760 SHRSP.SHR-(rs198233821-rs198932221)/Utx A congenic strain made by introducing IgH haplotype block (a segment of chr6:146,030,387 to 154,214,590 ,Rn5 assembly of the rat genome). from SHR-B2 (SHR/Utx) into SHR-A3 (SHRSP/BbbUtx). The igH block contains sequences that are highly divergent between of SHR-A3 and SHR-B2 . University of Texas, Houston, TX congenic Unknown 6 137279131 144688132 1 - by flanking markers 6 146030387 154214590 1 - by flanking markers 6 137021260 145293041 1 - by flanking markers RRID:RGD_150429760 150429814 SD-Gnalem1Hpng+/- The heterozygousGnal mutant rats were created by CRISPR/Cas9. Guide RNA sequences targeting the first exon of the rat Gnal gene isoform 2 were designed. The mutated allele contained a 13- bp deletion in exon1 that corresponded to position 34 to 46 downstream of the translation start point ATG of the Gnal splicing variant 2 was detected resulting in an early stop at position 150 and producing a truncated protein with 50 amino acids . Core Facility Transgenic Animals, University Clinics Tuebingen, Tuebingen, Germany mutant Unknown Gnalem1Hpng 150429816 18 63595606 63735803 1 - by flanking markers 18 61991738 62131420 1 - by flanking markers 18 62805406 62946133 1 - by flanking markers 18 60622311 60762599 1 - by flanking markers RRID:RGD_150429814 150429815 SD-Gnalem1Hpng+/+ The homozygous wild type Gnal rats were littermates of SD-Gnalem1Hpng+/- (RGD:150429814) created by CRISPR/Cas9. The heterozygous mutants carried one copy of mutated allele contained a 13- bp deletion in exon1 that corresponded to position 34 to 46 downstream of the translation start point ATG of theGnal splicing variant 2 was detected resulting in an early stop at position150 and producing a truncated protein with 50 amino acids . Core Facility Transgenic Animals, University Clinics Tuebingen, Tuebingen, Germany mutant Unknown RRID:RGD_150429815 150429817 SD-Gnalem1Hpng-/- Thehomozygous Gnal mutant rats were created by CRISPR/Cas9. Guide RNA sequences targeting the first exon of the rat Gnal gene isoform 2 were designed. The mutated allele contained a 13- bp deletion in exon1 that corresponded to position 34 to 46 downstream of the translation start point ATG of the Gnal splicing variant 2 was detected resulting in an early stop at position 150 and producing a truncated protein with 50 amino acids. Only 5% of homozygous Gnal knockout mice could survive till maturity Core Facility Transgenic Animals, University Clinics Tuebingen, Tuebingen, Germany mutant Unknown Gnalem1Hpng 150429816 18 63595606 63735803 1 - by flanking markers 18 61991738 62131420 1 - by flanking markers 18 62805406 62946133 1 - by flanking markers 18 60622311 60762599 1 - by flanking markers RRID:RGD_150429817 150429818 BN/HsdMcwiRrrc Inbred from a single pair of SsN line rats obtained from Harlan Sprague Dawley (Alabama colony). Maintained at the Medical College of Wisconsin since 1995. To confirm homozygosity, the strain was tested with 200 microsatellite markers (genome-wide scan at 20cM) all of which were homozygous for all regions tested (Cowley et al. 2000, Physiol. Genomics. 2:107-115). This strain was maintained at RRRC. Rat Resource & Research Center inbred Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2021-09-30) RRID:RRRC_00562 150429825 SD-Scn9a*tm1Amgn/Crl Exon 25 of the rat Scn9a gene was replaced with the human SCN9A exon counterpart (exon 26) using ZFN technology. The mRNAs of the active ZFN pair targets middle region of the exon (CACCATCATGGTTCTTATAtgcctcAACATGGTAA CCATGATG, ZFN binding sites in uppercase). This Sprague Dawley (SD) rat model was designed by Amgen, adapted and executed by SAGE Labs, Sigma-Aldrich and maintained in Charles River Laboratories. mutant Unknown Scn9a*tm1Amgn 150429827 3 48438725 48518893 1 - by flanking markers 3 59207264 59286961 1 - by flanking markers 3 52583953 52664209 1 - by flanking markers 3 51145148 51293342 1 - by flanking markers RRID:RGD_150429825 150429828 SD-Tspoem1Vpl Tspo-targeted genome editing in Sprague Dawley rats embryos by microinjecting with optimized and customized ZFNs designed for targeted gene KO. Locus-specific PCR was performed to identify Rat5 founders using the following primer pairs: CKOZFN-F: 50-AGAGCATACTCTTGCCGTCG-30 and CKOZFN-R:50-ACTCCTAAAGGGGTTGCAGG-30; Normal PCRs generated 362 bp for the WT and 273 bp for the mutant,(89 bp deletion). McGill University and Genome Quebec Innovation Centre (Montreal, Canada) mutant Unknown Tspoem1Vpl 150429831 7 121597084 121599342 1 - by flanking markers 7 124449361 124459090 1 - by flanking markers 7 124460358 124470610 1 - by flanking markers 7 114720188 114730450 1 - by flanking markers RRID:RGD_150429828 150429830 SD-Tspoem2Vpl Tspo-targeted genome editing in Sprague Dawley rats embryos by microinjecting with optimized and customized ZFNs designed for targeted gene KO. Locus-specific PCR was performed to identify Rat7 founders using the following primer pairs: COMPOZr-1kbF: 50-CCTGGATATGCTGTGTCCCC-30 and COMPOZr-1kbR: 50-TGATGGGTCATTTGTGCCCT-30.; Normal PCRs generated 818 bp for WT and 652 bp for the mutant (166 bp deletion). McGill University and Genome Quebec Innovation Centre (Montreal, Canada) mutant Unknown Tspoem2Vpl 150429832 7 121597084 121599342 1 - by flanking markers 7 124449361 124459090 1 - by flanking markers 7 124460358 124470610 1 - by flanking markers 7 114720188 114730450 1 - by flanking markers RRID:RGD_150429830 150429960 WIC-Wwoxlde/Fta Established from a closed colony of Wistar-Imamichi (WIC) rats as a spontaneous mutant exhibiting severe dwarfism, short lifespan (early postnatal lethality), and high incidence of epileptic seizures. Mutant rats showed growth retardation after 3 d of age, and at 21 d their weight was about 56% that of normal rats. Sequencing of the full-length Wwox transcript identified a 13-bp deletion in exon 9 in lde/lde rats. This mutation causes a frame shift, resulting in aberrant amino acid sequences at the C-terminal. Laboratory of Veterinary Physiology, Nippon Veterinary and Life Science University, Tokyo mutant Unknown Wwoxlde 150429961 19 44516391 44829849 1 - by flanking markers 19 57582172 58503008 1 - by flanking markers 19 46761353 47695247 1 - by flanking markers 19 42432141 43360278 1 - by flanking markers RRID:RGD_150429960 150429963 WI-Pmchm1Hubr The Pmch mutant rat line was generated by target-selected ENU-driven mutagenesis, and high-throughput resequencing of genomic target sequences in progeny from mutagenized rats (Wistar/Crl background) revealed an ENU-induced premature stop codon in exon 1(K50X) of Pmch in a rat. The heterozygous mutant rat was backcrossed to wild-type Wistar background for six generations to eliminate confounding effects from background mutations induced by ENU. Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands. Hera Biolabs, Taconic. mutant Unknown Pmchm1Hubr 150429964 7 24778133 24779449 1 - by flanking markers 7 28764993 28766309 1 - by flanking markers 7 28655206 28656522 1 - by flanking markers 7 22511934 22513250 1 - by flanking markers RRID:RGD_150429963 150429965 SD-Apoa4em1Bcgen TALEN system targeting the rat Apoa4 gene was injected to Sprague Dawley embryos. An 8 bp deletion was induced within the coding region of Apoa4 gene, which results in a frameshift and gene knockout. The genotypes were confirmed by PCR analysis followed by Sanger sequencing and agarose electrophoresis (PCR forward primer: 5′-TATCCCAACTCCAACATCATCCA-3′, reverse primer: 5′-TCGCAGTCTGATCCCACTTACTT-3′). The knockout allele generated a band at 237 bp, while the wild-type allele was at 245 bp. Beijing Biocytogen Co., Ltd. (Beijing, China). mutant Unknown Apoa4em1Bcgen 150429966 8 49233142 49233431 1 - by flanking markers 8 49163055 49165333 1 - by flanking markers 8 50536983 50539371 1 - by flanking markers 8 46539083 46541464 1 - by flanking markers RRID:RGD_150429965 150429988 SHR-Tg(Ef1a-Wars2)Ipcv This strain was derived by microinjecting fertilized eggs with a mix of the Sleeping Beauty construct containing BN Wars2 cDNA under control of the universal EF-1α promoter and mRNA of the SB100X transposase (Ivics et al. 2014). Transgenic rats were detected using PCR with the following primers: Wars2-F 5'-TGT GCT ACA AGT CCA CAC AC-3' and Wars2-R 5'-GCA GAA GGG TCA CGA AGA GA-3'. Czech Academy of Sciences, Prague, Czech Republic transgenic Unknown Wars2 1593417 RRID:RGD_150429988 150517549 SS.SHR-(D2Rat46- D2Mco48)/Mco This SS congenic carries the chromosomal fragment from the spontaneously hypertensive rat (SHR). Recombinant Progeny Testing (RPT) was used to fine-map the proteinuria locus. The congenic was developed from the recombinant families by fixing the transferred genomic interval (D2Rat46- D2Mco48) in the homozygous SHR/SHR state University of Toledo Toledo, Ohio congenic Unknown 2;20 174932771;29853888 190428097;29855558 1 - by flanking markers;1 - by flanking markers 2;20 201609408;34115408 201609573;34116469 1 - by flanking markers;1 - by flanking markers 2 182194909 182195074 1 - by flanking markers 2 168559501 168559667 1 - by flanking markers RRID:RGD_150517549 150517550 SS.SHR-(D2Rat127- D2Rat230)/Mco This SS congenic carries the chromosomal fragment from the spontaneously hypertensive rat (SHR). Recombinant Progeny Testing (RPT) was used to fine-map the proteinuria locus. The congenic was developed from the recombinant families by fixing the transferred genomic interval (D2Rat127- D2Rat230) in the homozygous SHR/SHR state University of Toledo Toledo, Ohio congenic Unknown 2 177914620 177914774 1 - by flanking markers 2 204650681 204650836 1 - by flanking markers RRID:RGD_150517550 150519895 SD-Gfapem1Mes /Rrrc The targeted mutation in the rat GFAP gene was based on the severity and frequency of the R239H mutation in human disease. The CRISPR/Cas9 system was used to mediated knockin of point mutation (R237H) to Sprague-Dawley embryos. The current background srain is Crl:CD (SD). This mutant strain serves as a model for Alexander disease. knockins have post-weaning failure to thrive and ~10% mortality by 12 weeks, but afterwards are viable and can breed . Rat Resource and Research Center mutant Unknown Gfapem1Mes 150519905 10 92059881 92068555 1 - by flanking markers 10 90763150 90771823 1 - by flanking markers 10 90990762 90999435 1 - by flanking markers 10 87852891 87861631 1 - by flanking markers RRID:RRRC_00932 150519896 SD-Gfapem2Mes /Rrrc CRISPR/Cas9 mediated single nucleotide deletion resulting in a frameshift that creates a premature stop and generates a null allele. This strain serves as a model for Alexander disease - nulls are of interest for traumatic brain injury and many other studies of CNS disease and astrocyte response. Rat Resource and Research Center mutant Unknown Gfapem2Mes 150519906 10 92059881 92068555 1 - by flanking markers 10 90763150 90771823 1 - by flanking markers 10 90990762 90999435 1 - by flanking markers 10 87852891 87861631 1 - by flanking markers RRID:RRRC_00931 150519899 F344-Prkar1bem1Tua CRISPR/Cas9 system containing guide RNAs targeting exon 2 and intron 2 were introduced into the F344/Stm embryos using a super electroporator NEPA 2. This mutant strain F344-Prkar1bem1Tua carried a 2-bp frameshift insertion in exon2 creating a premature stop codon in the Prkar1b transcripts. Expression levels of Prkar1b transcripts and protein are significantly decreased in the mutants. Department of Animal Science Faculty of Agriculture Tokyo University of Agriculture 1737 Funako Atsugi Kanagawa 243-0034 Japan mutant Unknown Prkar1bem1Tua 150519902 12 16025867 16131129 1 - by flanking markers 12 19611694 19708682 1 - by flanking markers 12 17614536 17713567 1 - by flanking markers 12 15492233 15624942 1 - by flanking markers RRID:RGD_150519899 150519901 F344-Prkar1bem2Tua CRISPR/Cas9 system containing guide RNAs targeting exon 2 and intron 2 were introduced into the F344/Stm embryos using a super electroporator NEPA 2. This mutant strain F344-Prkar1bem2Tua carried a 13-bp frameshift deletion in exon2 creating a premature stop codon in the Prkar1b transcripts. Expression levels of Prkar1b transcripts and protein are significantly decreased in the mutants. Department of Animal Science Faculty of Agriculture Tokyo University of Agriculture 1737 Funako Atsugi Kanagawa 243-0034 Japan mutant Unknown Prkar1bem2Tua 150519903 12 16025867 16131129 1 - by flanking markers 12 19611694 19708682 1 - by flanking markers 12 17614536 17713567 1 - by flanking markers 12 15492233 15624942 1 - by flanking markers RRID:RGD_150519901 150520049 WBN-Ht/Kob The hairless rat was orginially found in JCL:Wistar rats at Ishikawa Laboratory Animal company, Saitama, Japan. Thereafter, hairless rats were backcrossed with WBN rats for 8 generations and the congenic strain of hairless rats has been established with a background of WBN at the company. congenic Unknown RRID:RGD_150520049 150520052 SS-Mlycdem1Mcwi CRISPR/Cas9 system was used to introduce a mutation in the Mlycd gene of SS/JrHsdMcwi rat embryos. This resulted in a global knock-out of the rat Mlycd gene. Please contact: mcwcustomrats@mcw.edu mutant Unknown RRID:RGD_150520052 150520162 Kwl:Wistar Kiwa Laboratory Animals Co., Ltd. Japan outbred Unknown RRID:RGD_150520162 150520182 LE-ROSA26em1(CAG-tdTomato)Rrrc The DNA construct was made by replacing ZsGreen with TdTomato in plasmid pCAG-loxP-STOP-loxP-ZsGreen (Addgene plasmid #51269, donated by Pawel Pelczar). CRISPR/Cas9 genome editing technology was used to knock in the DNA construct into the rat Rosa26 locus in the embryos from outbred BluHsd:LE. Reporter line that can be crossed with Cre-expressing strains. In presence of Cre, the floxed "STOP" upstream of the TdTomato gene is deleted allowing expression of the red fluorescent TdTomato protein. Rat Resource and Research Center mutant Live Animals (as of 2021-11-03) RRID:RRRC_00938 150520183 BDIX.BDIV-Mss1c/ZteRrrc strain haboring on a BDIX background a 22,3 MB BDIV Fragment called Mss1c which covers part of the Mss1 fragment. Homozygous rats of both sexes display resistence towards ENU-induced development of PNS tumors in terms of survival time and incidence. Rat Resource and Research Center congenic Unknown RRID:RRRC_00904 150520185 SD-Ldlrem1Dlli Zygotes of SD rats were microinjected with CRISPR/Cas9 system targeting Ldlr . This mutant possesses a 118-bp deletion from No.22759599bp to 22759716bp in the Ldlr gene (NC_005107.4), resulting in a termination codon TAG, and deletion of 768 amino acids of Ldlr. mutant Unknown Ldlrem1Dlli 150520193 8 20824040 20846920 1 - by flanking markers 8 22804325 22827199 1 - by flanking markers 8 22750425 22773305 1 - by flanking markers 8 20270020 20292981 1 - by flanking markers RRID:RGD_150520185 150520186 SD-Apoeem1Dlli carried a 130 bp deletion from No.80613571bp to 80613700bp in Apoe gene (NC_005100.4), resulting in a termination codon TAA, and deletion of 231 amino acids of ApoE. Shanghai Key Laboratory of Regulatory Biology East China Normal University, Shanghai, China mutant Unknown RRID:RGD_150520186 150520187 LE-Apoeem1DlliLdlrem1Ldlr This Apoe/Ldlr double knock-out (DKO) was derived from cross-breeding of SD-Apoeem1Dlli (RGD:150520186) and SD-Ldlrem1Dlli (150520185). mutant Unknown RRID:RGD_150520187 150520189 SD-Apoeem1Ejt The mutant rat strain was produced by injecting TALEN system targeting the exon 4 of rat Apoe into Sprague Dawley (Hsd:SD) embryos. This mutant rat has a 16-bp deletion in the gene third coding exon) located on chromosome 1; frameshift mutation resulted (p.Glu178fs) Purdue Center for Cancer Research, 201 South University Street, Purdue University, West Lafayette, Indiana, 47907, United States mutant Unknown Apoeem1Ejt 150520190 1 79003634 79006387 1 - by flanking markers 1 81878372 81882298 1 - by flanking markers 1 80612894 80616820 1 - by flanking markers 1 79353924 79357852 1 - by flanking markers RRID:RGD_150520189 150520204 SHR/OlaIpcv-mtLEW/Ipcv Mitochodrial genome of SHR/OlaIpcv was selectively replaced by LEW/Ipcv to create this conplastic strain using the supersonic breeding strategy; these have the mitochondrial genome of LEW/Ipcv on SHR/OlaIpcv nuclear genetic background. Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic conplastic Unknown RRID:RGD_150520204 150520205 SHR-Gja8m1+/-Cub This strain is derived from SHR/OlaIpcv where a spontaneous mutation was observed in the NH2-terminal cytosolic domain of Cx50, L7Q. The connexin50 mutation in heterozygous state affects significantly the lipid profile and the oxidative stress parameters in SHR rats. Department of Biology, Charles University in Prague, Prague, Czech Republic coisogenic Unknown Gja8m1Cub 12791992 RRID:RGD_150520205 150520206 SHR-Tg(Ef1a-Folr1 )Ipcv Generated by microinjecting SHR/OlaIpcv zygotes with wild type Folr1 cDNA from BN-Lx/Cub under control of EF-1α universal promoter Czech Academy of Sciences, Prague, Czech Republic transgenic Unknown RRID:RGD_150520206 150520207 F344-ROSA26em1(AttP)Davis/Rrrc The CRISPR/Cas9 system was used to introduce 2 AttP landing sites in the ROSA26 locus of F344/NHsd rat embryos. Rat Resource and Research Center (RRRC) mutant Cryopreserved Sperm (as of 2021-11-05) Tool rat for creating other trasngenic rat models RRID:RGD_150520207 150520208 ACI-Pvt1em1Shul Using CRISPR/Cas9, exon 1b of the Pvt1 gene was excised from the ACI/SegHsd genome in a 1165bp deletion. Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison mutant Live Animals (as of 2021-11-05) RRID:RGD_150520208 150520209 ACI-Pvt1em1Shul/Rrrc The ACI-Pvt1em1Shul was created using CRISPR/Cas9 by Shull laboratory at UW madison. The exon 1b of the Pvt1 gene was excised from the ACI/SegHsd genome in a 1165bp deletion. Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison. This strain is now maintained at Rat Resource and Research Center. mutant Unknown RRID:RGD_150520209 150520210 ACI-Pvt1em2Shul Using CRISPR/Cas9, a 568bp region of the Pvt1 gene was deleted from the ACI genome including all of exon 3. Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison mutant Live Animals (as of 2021-11-05) RRID:RGD_150520210 150520211 ACI-Pvt1em2Shul/Rrrc Using CRISPR/Cas9, a 568bp region of the Pvt1 gene was deleted from the ACI genome including all of exon 3. The strain was created at Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison. This strain is maintained at Rat Resource and Research Center. mutant Unknown (as of 2021-11-09) RRID:RGD_150520211 150520212 ACI-Pvt1em3Shul using CRISPR/Cas9, exon 8 of the pvt1 gene was deleted from the ACI genome. Resulting in a total excision of 588bp. Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison mutant Live Animals (as of 2021-11-05) RRID:RGD_150520212 150520213 ACI-Pvt1em3Shul/Rrrc using CRISPR/Cas9, exon 8 of the pvt1 gene was deleted from the ACI genome. Resulting in a total excision of 588bp. The strain was created at Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison. This strain is maintained at Rat Resource and Research Center. mutant Live Animals (as of 2021-11-05) RRID:RGD_150520213 150520214 ACI-Pvt1em4Shul CRISPR/Cas9 was used to delete miR1208 in a 763bp excision in ACI rat embryos. Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison mutant Live Animals (as of 2021-11-05) RRID:RGD_150520214 150520215 ACI-Pvt1em4Shul/Rrrc CRISPR/Cas9 was used to delete miR1208 in a 763bp excision in ACI rat embryos. The strain was created at Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison. This strain is maintained at Rat Resource and Research Center. mutant Unknown RRID:RGD_150520215 150520216 ACI-Pvt1em5Shul Using CRISPR/Cas9, a suspected enhancer of miR1208 was deleted in a 8315bp excision in ACI rat embryos. Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison mutant Live Animals (as of 2021-11-05) RRID:RGD_150520216 150520217 ACI-Pvt1em5Shul/Rrrc Using CRISPR/Cas9, a suspected enhancer of miR1208 was deleted in a 8315bp excision in ACI rat embryos. The strain was created at Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison. This strain is maintained at Rat Resource and Research Center. mutant Unknown RRID:RGD_150520217 150520220 SD-Ccdc39em1Jgn The CRISPR/Case9 system was desgined to create the progressive hydrocephalus (prh) mutation in Sprague Dawley rats. The homozygous rat carries chr2:g.120305679A>T change that creates a splice site (Ccdc39c.916+2T ) mutation in the rat Ccdc39 gene. Cincinnati Children's Hospital Medical Center, Cincinnati, OH mutant Unknown Ccdc39em1Jgn 150521525 2 120117112 120154958 1 - by flanking markers 2 139933049 139971476 1 - by flanking markers 2 120278605 120367829 1 - by flanking markers 2 116665261 116703364 1 - by flanking markers RRID:RGD_150520220 150520221 SD-Slco1b2em1Myliu The Sprague Dawley embryos were injected with CRISPR/Case9 system targeting the first exon of the rat Slco1b2 gene. A Slco1b2 knockout was created with 11-bp deletion. Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China mutant Unknown Slco1b2em1Myliu 150521524 4 179045586 179118680 1 - by flanking markers 4 240035313 240103015 1 - by flanking markers 4 175814118 175881775 1 - by flanking markers 4 174551463 174619988 1 - by flanking markers RRID:RGD_150520221 150521538 SD-Uoxem1Cya The CRISPR/Cas9 system targeting exons 2 to 4 was injected into Sprague Dawley embryos. The resulting mutation was complete deletion of exons 2, 3 and 4. Yunnan University of Traditional Chinese Medicine,and Kunming Medical University, Kunming, Yunnan, China. mutant Unknown Uoxem1Cya 150521540 2 244795552 244832143 1 - by flanking markers 2 270978811 271015097 1 - by flanking markers 2 252452282 252488497 1 - by flanking markers 2 235486867 235523053 1 - by flanking markers RRID:RGD_150521538 150521556 SD-Trpm4em1Sage Trpm4 gene specific Zinc finger constructs directed against exons 18-19, which contain the coding sequence for TM3-5 and the pore region of the TRPM4 protein, were injected in zygotes from Sprague-Dawley rats. This mutant rat with a 514 bp deletion which includes completely removes exon 18 and a piece of exon 19 from the Trpm4 gene, plus the intron 18-19. The deletion was confirmed via genomic sequencing and western blotting. Laboratory of Biological Psychology, Brain and Cognition, Katholieke Universiteit Leuven (KUL), Tiensestraat 102, 3000 Leuven, Belgium mutant Unknown RRID:RGD_150521556 150521559 LEW.SD-CD8am1Trg Male SD rats were treated with the mutagen N-ethyl-N-nitrosourea (60 mg/kg intraperitoneally) at ages 9 and 10 weeks. A heterozygous mutant founder carrying a T to C transition that encoded a substitution of a proline residue (CCA) for a highly conserved serine residue (TCA) at amino acid position 94 was identified. This mutant male was mated to a LEW female and phenotyping by the expression of CD8a and CD8ab. University of Texas Southwestern Medical Center, 5323 mutant Unknown RRID:RGD_150521559 150521599 SD-Tshrem1Mlit CRISPR/Cas9 system targeting exon 10 of the rat Tshr gene was injected into Sprague Dawley embryos to create this mutant strain. The strain was homozygous with 5 bp deletion (CACGC) which introduces frameshift at residue 449 and a stop codon at 478 (P449fsX478). Animal Center of Tongji University; Tongji University School of Medicine, Shanghai, 200065, China mutant Unknown Tshrem1Mlit 150521600 6 115024999 115162531 1 - by flanking markers 6 124509406 124561916 1 - by flanking markers 6 115170290 115306871 1 - by flanking markers 6 110341585 110475297 1 - by flanking markers RRID:RGD_150521599 150521602 OFA(SD)-Dsg4hr/Crl This Iffa Credo ( IC) hairless strain was a spontaneous recessive mutant identified in a colony of Crl:OFA(SD) at 1974. A large intracellular out-of-frame deletion in Dsg4 of IC mutant rats was identified. The intragenic deletion spanning exons 2?10 that results in a significant down-regulation of Dsg4 message. Iffa Credo (L'Arbresle Cedex, France; www.criver.com/ ico/iffa_reachus.html). mutant Unknown Dsg4hr 150521603 18 12173507 12209833 1 - by flanking markers 18 11853980 11888828 1 - by flanking markers 18 12056113 12092858 1 - by flanking markers 18 11720975 11756234 1 - by flanking markers RRID:RGD_150521602 150521604 WKY-Tnfrsf14em1Tja/Rrrc This strain was produced by injecting ZFNs targeted sequence into WKY/Cruk rat embryos. The resulting mutation 77 has a stop codon, 15 amino acids from the ZFN-binding site, that resulted in a 490 amino acids (54 kDa) truncated protein, 198 amino acids smaller than the WT protein. This strain was created by Tim Aitman at University of Edinburgh and now maintained at Rat Resource and Research Center mutant Cryopreserved Sperm; Cryorecovery (as of 2021-11-11) RRID:RRRC_00796 150521605 W/Lnne Audiogenic Wistar rat Wistar rats maintained at the animal facility of the Ribeirao Preto School of Medicine at the University of Sao Paulo, Brazil, were tested for audiogenic seizures, using as criteria an SI and the L1 (ref. RGD:14695082). The WAR colony foundation stock was produced by mating animals displaying at least procursive behaviors in three consecutive tests, one every 4 days (two males and four females). Each couple produced two or three lit-ters, from which selected individuals displaying the highest SI and shortest L1 were mated, at adult age,with their fathers and mothers. From the second generation on, brother and sister matings were done, in a ratio of one male to two females, selected accordingto the criteria above. Norberto Garcia-Cairasco at University of Sao Paulo inbred Unknown audiogenic seizures RRID:RGD_150521605 150521606 SD-Lrp5em2Vari/Rrrc CRISPR/Cas9 system was used to introduce a 22-bp deletion at the sgRNA2 site of exon 2 in the rat Lrp5 gene of Crl:SD embryos. Rat Resource and Research Center mutant Unknown Lrp5em2Vari 41404650 1 206102750 206206350 1 - by flanking markers 1 225689353 225793075 1 - by flanking markers 1 218816833 218920147 1 - by flanking markers 1 200814247 200917581 1 - by flanking markers RRID:RRRC_00880 150521608 SD-Lrp5em3Vari/Rrrc CRISPR/Cas9 system was used to introduce an inversion coupled with small deletions in the exon 2 at both the sgRNA1 (11 bp) and sgRNA2 sites (3 bp) in the rat Lrp5 gene of Crl:SD embryos. Rat Resource and Research Center mutant Unknown Lrp5em3Vari 41404652 1 206102750 206206350 1 - by flanking markers 1 225689353 225793075 1 - by flanking markers 1 218816833 218920147 1 - by flanking markers 1 200814247 200917581 1 - by flanking markers RRID:RRRC_00881 150521610 SD-Lrp5em1Vari/Rrrc CRISPR/Cas9 system was used to introduce a 18-bp deletion of exon 2 in the rat Lrp5 gene of Crl:SD embryos. Rat Resource and Research Center mutant Unknown Lrp5em1Vari 41404647 1 206102750 206206350 1 - by flanking markers 1 225689353 225793075 1 - by flanking markers 1 218816833 218920147 1 - by flanking markers 1 200814247 200917581 1 - by flanking markers RRID:RRRC_00867 150521611 BDIX.BDIV-D6Mit8-D6Rat229/ZteRrrc The BDIX.BDIV-D6Mit8-D6Rat229/Zte congenic strain was produced by crossing BDIX (tumor-susceptible) and BDIV (tumor resistant) and then selecting for strains carrying homozygous segments of the BDIV chromosome on a BDIX background. Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany. Rat Resource and Research Center congenic Unknown RRID:RRRC_00899 150521612 BDIX.BDIV-Mss1b/ZteRrrc strain haboring on a BDIX background two BDIV Fragments generated by a double recombination, 37,3 and 20,0 Mb long,Mss1b1 and Mss1b2 both covering parts of the Mss1 fragment. Homozygous rats of both sexes display susceptibility towards ENU-induced development of PNS tumors in terms of survival time and incidence. Through the Mss1b1 and Mss1b2 fragments and the Mss1c fragment the Mss1 locus was fine-mapped between 82.9 and 85.2Mb Rat Resource and Research Center congenic Unknown RRID:RRRC_00905 150521613 BDIX.BDIV-D6Mit1-D6Mgh2/ZteRrrc The BDIX.BDIV-D6Mit1-D6Mgh2/Zte congenic strain was produced by crossing BDIX (tumor-susceptible) and BDIV (tumor resistant) and then selecting for strains carrying homozygous segments of the BDIV chromosome on a BDIX background. Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany.Rat Resource and Research Center congenic Unknown RRID:RRRC_00901 150521614 BDIX.BDIV-D10Got1-D10Rat45/ZteRrrc The BDIX.BDIV-D10Got1-D10Rat45/Zte congenic strain was produced by crossing BDIX (tumor-susceptible) and BDIV (tumor resistant) and then selecting for strains carrying homozygous segments of the BDIV chromosome on a BDIX background. Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany. Rat Resource and Research Center congenic Unknown RRID:RRRC_00902 150521616 BDIX.BDIV-D10Mit3-D10Mgh16/ZteRrrc The BDIX.BDIV-D10Mit3-D10Mgh16/Zte congenic strain was produced by crossing BDIX (tumor-susceptible) and BDIV (tumor resistant) and then selecting for strains carrying homozygous segments of the BDIV chromosome on a BDIX background. Institute of Cell Biology (Cancer Research) of Duisburg-Essen University Medical School, Essen, Germany. Rat Resource and Research Center congenic Live Animals (as of 2021-11-12) RRID:RRRC_00903 150521617 BDIX/IfzRrrc BDIX/IFZ rats have been inbred in the Institute of Cell Biology, Essen and later in the Central Animal Facility,Essen for about 45 years. The BDIX/Ifz rats are extremely susceptible to ENU-induced development of tumors of the peripheral and central nervous system. Duisburg-Essen University Medical School, Essen, Germany. Rat Resource and Research Center inbred Unknown RRID:RRRC_00900 150521619 BDIV/lfzRrrc Substrain of BDIV, from cross between BDI and BDII single mating pair, with selection for coat color alleles (Druckrey 1971). BDIV/IFZ rats have been inbred in the Institute of Cell Biology, Essen and later in the Central Animal Facility for about 45 years. BDIX/Ifz rats are extremely resistant to ENU-induced development of tumors of the peripheral nervous System. Rat Resource and Research Center inbred Unknown RRID:RRRC_00898 150521659 FHH-Chr 1BN-Dusp5em1Mcwi/Rrrc This strain was produced by injecting ZFNs targeting the following sequence CAGGGCAGCCGC-CACtggcaGAAGCTGCGGGAGGA in exon 1 of the rat Dusp5 gene into FHH-Chr 1BN/Mcwi embryos. The resulting mutation is a 14 bp deletion and a 3 bp insertion between nucleotides 449 and 464 in Dusp5 mRNA that creates a frame shift mutation which is predicted to introduce a premature stop codon at amino acid 121. Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2021-11-15) RRID:RGD_150521659 150521660 LE-Tg(DIO-mCherry)2Ottc The transgene contains Cre recombinase reporter rat expressing mCherry driven by the EF1 alpha promoter. A Rrrc substrain available at Rat Resource and Research Center transgenic Unknown RRID:RGD_150521660 150521661 SD-Tg(DIO-mCherry)2OttcRrrc The transgene contains Cre recombinase reporter rat expressing mCherry driven by the EF1 alpha promoter. Expresses mCherry in cells of the brain transduced with a Cre-expression virus. Currently in SD background generated by backcrossing to LE-Tg(DIO-mCherry)2Ottc Rat Resource and Research Center transgenic Unknown RRID:RRRC_00928 150521675 BN/NHsdShul Inbred substrain derived from BN/SsNHsd(RGD:10008) Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison inbred Live Animals (as of 2021-11-16) RRID:RGD_150521675 150521676 ACI/SegHsdShul Inbred substrain of ACI of ACI derived from ACI/SegHsd Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison inbred Live Animals (as of 2021-11-16) RRID:RGD_150521676 150521677 BN/HsdShulRrrc Inbred substrain derived from BN/SsNHsd(RGD:10008) This substrain is transferred from Shull Lab, Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison to Rat Reource & Research Center in 2021. inbred Unknown RRID:RGD_150521677 150521708 SD-Tbc1d1Tn(sb)1Fkh The Sleeping Beauty transposon-mediated mutagenesis was used to knock out the rat Tbc1d1 gene in in rat spermatogonial stem cells from Sprague Dawley. University of Texas Southwestern Medical Center, Dallas TX mutant Unknown Tbc1d1Tn(sb)1Fkh 150521709 14 46594874 46781813 1 - by flanking markers 14 45404208 45603325 1 - by flanking markers 14 45598753 45797650 1 - by flanking markers 14 43936820 44135133 1 - by flanking markers RRID:RGD_150521708 150523755 SD-Ighmem1Ang The mutation in this rat strain (line 19) comprised a 64 bp deletion of the IgM CH1 domain and generation of a stop codon. This strain carries deletion in both alleles has truncated Cmu. Platform Rat Transgenesis IBiSA-CNRS, Nantes, France. mutant Unknown Ighmem1Ang 150523756 RRID:RGD_150523755 150523757 SD-Ighmem2Ang Microinjection of Sprague-Dawley rat zygotes with ZFN mRNA specific for the JH locus resulted in the generation of a mutant animal with a 2465 bp DNA deletion, spanning the entire locus Platform Rat Transgenesis IBiSA-CNRS, Nantes, France. mutant Unknown Ighmem2Ang 150523758 RRID:RGD_150523757 150523775 LEW-Tg(HLA-B*2705,B2M)Tg/021-3Reh Rrrc This strain was made by pronuclear injection into LEW/Crl embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene and the human beta-2-microglobulin gene. The strain carries 20 copies of HLA-B*2705 and 15 copies of the human beta-2-microglobulin gene. This strain is now available at Rat Resource and Research Center transgenic Cryopreserved Sperm; Cryorecovery (as of 2022-03-10) RRID:RRRC_00916 150523778 LEW-Tg(B2M)283-2RehRrrc This strain carries 35 copies of genomic human B2-microglobulin gene. When crossed with the 21-3 line (RRRC:00 916), the F1 males develop a spontaneous disease mimicking human spondyloarthritis. Rat Resource and Research Center transgenic Cryopreserved Sperm; Cryorecovery (as of 2022-03-10) RRID:RRRC_00917 150523780 LEW-Erap1em1Reh2786/Rrrc The ZFN mRNA targeting exon 2 of Erap1 was microinjected into both the pronuclei and the cytoplasm of fertilized LEW eggs. This strain was heterozygous for a 2-bp deletion within the targeted AGGAGA sequence of Erap1. Rat Resource and Research Center mutant Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2021-11-19) RRID:RRRC_00918 150523781 LEW-Erap1em1Reh2786 The ZFN mRNA targeting exon 2 of Erap1 was microinjected into both the pronuclei and the cytoplasm of fertilized LEW eggs. This strain was heterozygous for a 2-bp deletion within the targeted AGGAGA sequence of Erap1. University of Texas Southwestern Medical Center mutant Unknown RRID:RGD_150523781 150524338 SD-Tg(ERAP1*)2793RehRrrc This transgenic rat carrying the human " II or *002" allele of ERAP1 under mouse H-2K promoter control. The construct was made by Dr. Edd James, University of Southampton, UK. The II allele is generally considered to be a risk allele for ankylosing spondylitisThe original background strain is SD and the current background strain is mixed Lewis x SD. Rat Resource and Research Center transgenic Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2021-11-29) RRID:RRRC_00919 150526804 AZK/Misiv Azman Kamal rats The rat was derived from inbreeding of Sprague Dawley rats for 3 years. Because of longer inbreeding process we got SD progenies without fur. So, this rat is used for wound healing study in our facility. Forest Research Institute Malaysia inbred Live Animals (as of 2021-12-01) Wound healing RRID:RGD_150526804 150526809 SD-Artfm/Rrrc This spontaneous mutant strain was originally derived from King Holtzman background and now maintained in Sprague Dawley background. A single nucleotide mutation was identified in the androgen receptor gene. The tfm males are sterile so the mutation is carried via females who breed normally. Donated by Cynthia Jordan from Michigan State University, now available at Rat Resource and Research Center mutant Unknown RRID:RRRC_00940 150527860 BDIX/OrlIco BDIX Rats Rats selected in 1937 by H. Druckrey in Berlin from a strain of yellow coated, pink-eyed rats. It is part of a series of BD I to X strains produced at Max Planck Institute, Freiburg and was introduced to France in 1971 to the INSERM unit, Immunology Laboratory, Dijon where it was maintained in strict brother-sister inbreeding. Developed and studied by Dr. Ms. Martin, CNRS/CSEAL, Orleans (Orl) acquired by IFFA CREDO later (Ico). Charles River Laboratories inbred Unknown RRID:RGD_150527860 150573816 SD-Nkx3-1em1Pjhak+/- A pair of TALENs targeting coding region of rat Nkx3-1gene was electroporated into SD zygotes to create NKx3-1 mutants. The resulting mutation was indel mutation with sequences loss beyond TALEN recognition resulting a premature termination codon of the protein. Department of Laboratory Animal Medicine College of Veterinary Medicine Seoul National University mutant Unknown Nkx3-1em1Pjhak 150573819 15 49743313 49745905 1 - by flanking markers 15 54796102 54798694 1 - by flanking markers 15 51065316 51067908 1 - by flanking markers 15 44473851 44476443 1 - by flanking markers RRID:RGD_150573816 150573818 SD-Nkx3-1em1Pjhak-/- A pair of TALENs targeting coding region of rat Nkx3-1gene was electroporated into SD zygotes to create NKx3-1 mutants. The resulting mutation was indel mutation with sequences loss beyond TALEN recognition resulting a premature termination codon of the protein. Department of Laboratory Animal Medicine College of Veterinary Medicine Seoul National University mutant Unknown Nkx3-1em1Pjhak 150573819 15 49743313 49745905 1 - by flanking markers 15 54796102 54798694 1 - by flanking markers 15 51065316 51067908 1 - by flanking markers 15 44473851 44476443 1 - by flanking markers RRID:RGD_150573818 151347605 SD-Ddah1em1Ywxu CRISPR-Cas9 technique was used to generate DDAH1-/- rats on Sprague-Dawley background. Genome deletion in exon 1 was confirmed by PCR analysis with the primers:DDAH1-F (5'-GCGCTGCTCTCGGGAAGA-3') and DDAH1-R (5'-GGGTGATGAGGGCGGTCT-3'). Cardiovascular Department, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, China mutant Unknown Ddah1em1Ywxu 151347606 2 243932221 244069832 1 - by flanking markers 2 270160842 270289319 1 - by flanking markers 2 251634368 251766009 1 - by flanking markers 2 234667499 234800322 1 - by flanking markers RRID:RGD_151347605 151347873 Slc:ZUC-Leprfa+ Zucker lean rats The Zucker lean rats were siblings of Zucker fatty rats. They were used as lean controls for Zucker fatty rats studies. This strain was available at Japan SLC, Inc. (Hamamatsu, Japan.) Japan SLC, Inc. (Hamamatsu, Japan) outbred Unknown Lepr 3001 RRID:RGD_151347873 151356741 SD-Tg(Alb-TAg)Mlcr This transgenic strain was generated by microinjection into outbred Sprague-Dawley from Harlan Sprague-Dawley (Hsd:SD) fertilized eggs and carries simian virus T Antigen drived by the enhancer/promoter region of the mouse albumin gene. McArdle Laboratory for Cancer Research, Medical School, University of Wisconsin, Madison, Wisconsin 53706-1599, USA. transgenic Unknown RRID:RGD_151356741 151356945 LE-ROSA26em1(EF1a-TetR, Fos-iCre)/Bhope Two DNA expression constructs, the bacterial tetracyclin repressor (TetR) under the expression control of human EF1a promoter and the improved Cre recombinase (iCre) under Fos promoter were joined in an antiparallel orientation in one rat ROSA26 targeting cassette. The DNA construct, together with CRISPR /Cas9 system, was injected to one cell Long-Evans (Crl:LE) rat embryos and founders were identified and bred for 8 generations at at NIDA IRP (Hope lab). NIDA IRP (Hope lab). mutant Unknown RRID:RGD_151356945 151356946 LE-ROSA26em1(EF1a-TetR, Fos-iCre)/BhopeRrrc Two DNA expression constructs, the bacterial tetracyclin repressor (TetR) under the expression control of human EF1a promoter and the improved Cre recombinase (iCre) under Fos promoter were joined in an antiparallel orientation in one rat ROSA26 targeting cassette. The DNA construct, together with CRISPR /Cas9 system, was injected to one cell Long-Evans (Crl:LE) rat embryos and founders were identified and bred for 8 generations at at NIDA IRP (Hope lab). Rat Resource and Research Center mutant Unknown RRID:RRRC_00953 151356950 WI-Tg(Fos-LacZ)BhopeRrrc The lacZ gene was inserted between NcoI and SalI sites in exon 4 of the murine Fos gene . The linearized DNA was then microinjected into fertilized rat oocytes and line 1-8 was chosen for continuation. Initial SD rats were then bred onto Wistar background for >10 generations at NIDA IRP (Bruce Hope lab) Rat Resource and Research Center transgenic Unknown RRID:RRRC_00952 151356957 Sah:SD Sprague-Dawley maintained at South Australian Health and Medical Research Institute North Terrace Adelaide SA 5000 Australia outbred Unknown RRID:RGD_151356957 151356958 SD-Cftrem1Apb The CRISPR/Cas9 system was used to target exon 11 to create a deletion at codon F508 which was injected into Sprague-Dawley one-cell embryos (C076 line). One rat had an allele that contained the desired homology-directed repair edited TTT deletion and was designated the Phe508del founder (c.1522_1524delTTT). Organization: Australian Phenomics Facility, Australian National University mutant Unknown Cftrem1Apb 151660342 RRID:RGD_151356958 151356959 SD-Cftrem2Apb The CRISPR/Cas9 system was used to target exon 11 and create a deletion at codon F508, which was injected into Sprague-Dawley one-cell embryos (C076 line). A rat with an 8-bp deletion upstream of the TTT site (c.1514_1521delATATCATC) was used to establish the KO strain. Organization: Australian Phenomics Facility, Australian National University mutant Unknown Cftrem2Apb 151660343 RRID:RGD_151356959 151356971 RjOrl:LE This model was developed by Dr Long and Dr Evans in 1915. The LONG EVANS rat is the result of a cross between a female albino from the WISTAR Institute and a wild male (Rattus norvegicus) captured near Berkeley and offspring selection. The LONG EVANS rat is small and resistant to oncogenesis. This strain is widely used in behavioral, learning, ageing (visual acuity less affected than that of albino strains), addiction - especially to alcohol - studies. Janvier outbred Live Animals; Cryopreserved Embryo (as of 2022-02-21) RRID:RGD_151356971 151356985 LE-Tg(cFos-eGFP)Bhope This LE transgenic rats were created by injecting the cfos-eGFP construct to pronuclei of fertilized eggs obtained from Long Evans females. The 5 prime end of the transgenic DNA construct contained mouse genomic cFos (indluding the promoter and all exon and intron sequences) was fused with eGFP (including poly(A) tail derived from the IRES (phosphorylated-internal ribosomal entry site) of the EGFP Clontech (Cambridge, UK) vector. A single founder animal was identified. All subsequent breeding used hemizygous cfos-GFP male rats paired with wild-type Long Evans female rats obtained from Charles River Laboratories. Rats were bred on Long-Evans background for 13 generations at NIDA IRP (Hope lab). NIDA IRP (Hope lab) transgenic Unknown RRID:RGD_151356985 151356988 LE-Tg(cFos-eGFP)BhopeRrrc This transgenic was created by Dr. Bruce Hope at at NIDA IRP and donated to RRRC in 2022. The transgenic rats were created by injecting the cfos-eGFP construct to pronuclei of fertilized eggs obtained from Long Evans females. The 5 prime end of the transgenic DNA construct contained mouse genomic cFos (indluding the promoter and all exon and intron sequences) was fused with eGFP (including poly(A) tail derived from the IRES (phosphorylated-internal ribosomal entry site) of the EGFP Clontech (Cambridge, UK) vector. A single founder animal was identified. All subsequent breeding used hemizygous cfos-GFP male rats paired with wild-type Long Evans female rats obtained from Charles River Laboratories. Rats were bred on Long-Evans background for 13 generations Rat Resource and Research Center transgenic Unknown RRID:RRRC_00954 151664748 SD-Slc9a6 em1Moro CRISPR/Cas9 system was used to generate this mutant. Guide RNA sequence is the following: 5'-CGGCTGTGTAACCCTGATGA-3'. Cas9-mediated cleavage at exon 7 in the Slc9a6 locus resulted in the insertion of 2 bp (TT) generating frameshift and a premature stop codon. Organization: Brown University 70 Ship Street, Box G-E4 Providence RI 02912 USA mutant Unknown Slc9a6 em1Moro 151664749 X 141146237 141201234 1 - by flanking markers X 153620082 153675717 1 - by flanking markers X 158979081 159045019 1 - by flanking markers X 134430588 134486747 1 - by flanking markers RRID:RGD_151664748 151665324 SS-Ucp2em1Mcwi Generated by CRISPR/Cas9 mutagenesis of SS/JrHsdMcwi rats by Aron Geurts. The resulting mutation is a 23-bp deletion (rn7: chr1:154,842,967-154,842,989) Medical College of Wisconsin, contact MCW Rat Distribution at mcwcustomrats@mcw.edu mutant Cryopreserved Sperm (as of 2022-03-18) RRID:RGD_151665324 151665772 WI-Tfap2cem1(tdTomato)Nips The targeting vector was designed to replace the stop codon of Tfap2c with T2A-tdTomato. The adeno-associated virus carrying the targeting vector was infected to Crlj:WI (RGD ID: 2312504) rat 1 cell zygotes followed by the introduction of CRISPR/Cas9 ribonucleoprotein complex by electroporation. After incubation overnight, the zygotes were transferred into oviducts of pseudo-pregnant rats. The pups were judged correct gene-targeting by genomic PCR. These rat strains are being maintained by crossing the founder rats with Crlj:WI rats. The tdTomato fluorescence faithfully label Tfap2c expressing cells. Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi 444-8787, Japan. or Division of Mammalian Embryology, Center for Stem Cell Biology and Regenerative Medicine, The Institute for Medical Science, The University of Tokyo, Tokyo108-8639, Japan. mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2022-04-01) RRID:RGD_151665772 151667414 LE-Ckmtm1(cre)/Rrrc This model expresses cre-recombinase under the control of the endogenous Ckm (creatine kinase, M-type) promoter. Cre was targeted to the rat Ckm gene of LE embryos through CRISP/Cas9 system genome editing system. This strain will be deposited with RRRC Rat Resource and Research Center mutant Unknown RRID:RGD_151667414 151893484 SS-Tg(CAG-Fh)A1Mcwi This is a transgenic model created using Sleeping Beauty system. The transgenic animals are overexpressing fumarate hydratase (Fh) under the control of the ubiquitous CAG promoter in the Dahl salt-sensitive strain background. Medical College of Wisconsin, contact MCW Rat Distribution at mcwcustomrats@mcw.edu transgenic Live Animals; Cryopreserved Sperm (as of 2022-04-21) RRID:RGD_151893484 152975964 SS-F8em2Mcwi Full gene inversion of the rat F8 gene introduced by CRISPR/Cas9, to DahlSS background rats. This inversion causes a premature stop codon 3 amino acids into the protein. F8 activity in rats, homozygous for the mutation, is undetectable. Blood Research Institute 8733 W Watertown Plank Road Milwaukee, WI 53226, Contact MCW Rat Distribution at mcwcustomrats@mcw.edu mutant Unknown RRID:RGD_152975964 152975965 SS-F8em2Mcwi-Tg(ITGA2B-F8*)Mcwi This transgenic was produced by crossing the SS transgenic rat carrying Lentivirus constructs containing the 2bF8 vector [B-domain deleted human FVIII under control of ITGA2B (IIb) promoter] with an F8 knockout rat SS-F8em2Mcwi (RGD:152975964). This transgenic rat strain expressed B-domain deleted human F8 under the control of ITGA2B promoter in the absence of rat F8 product. Blood Research Institute 8733 W Watertown Plank Road Milwaukee, WI 53226, contact MCW Rat Distribution at mcwcustomrats@mcw.edu transgenic Unknown RRID:RGD_152975965 152977766 LE-Tg(Drd2-IL2RA/YFP)1Koba Background strain: Iar:LE (Institute for Animal Reproduction) ( RGD:18337282). This strain was generated by injecting a modified BAC, in which a fusion protein created from the human IL2R alpha-subunit gene (IL2RA) and YFP was inserted into the second exon of the rat Drd2 gene, into fertilized eggs of Long-Evans rats. National BioResource Project for the Rat in Japan transgenic Cryopreserved Sperm (as of 2022-07-06) RRID:RGD_152977766 152977768 WIC-Tg(Oprk1-YFP*)1Utthe The KOR-Venus construct consisting of promoter of rat Oprk1 (opioid receptor, kappa 1) fused with Venus fluorescent protein, was introduced into fertilized eggs of Wistar rats (Crlj:WI, Charles River Japan). They were then crossed with Wistar-Imamichi rats (Iar:Wistar-Imamichi, Institute for Animal Reproduction) to maintain the strain. Transgenic rats expressing the fluorescent protein Venus under the control of the Oprk1 promoter. This strain is heterozygous. National BioResource Project for the Rat in Japan transgenic Unknown RRID:RGD_152977768 152985526 WIC-Cdkn2aem1Kyhs A 7-bp deletion in exon 1 of the Cdkn2a (p16) gene was introduced by the CRISPR/Cas9. Genetic background is Iar:Wistar-Imamichi (Institute for Animal Reproduction) (RGD:125097496). Introducing the deletion mutation in the Cdkn2a (p16) gene into the background of DMD rats (muscular dystrophy model rats) improves muscle pathology. National BioResource Project for the Rat in Japan mutant Unknown RRID:RGD_152985526 152995284 W/Nov Substrain of Wistar, now bred at the Institute of Cytology and Genetics, Russian Academy of Sciences (Novosibirsk) Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia inbred Unknown RRID:RGD_152995284 152999000 LE-Fxn em2Fara-/+ Heterozygous KO of the Fxn gene obtained by targeting exon 4 with CRISPR/Cas9 system This strain has been deposited with RRRC mutant Unknown Fxn em2Fara 152999006 1 227647092 227671081 1 - by flanking markers 1 249400435 249426597 1 - by flanking markers 1 242123975 242152834 1 - by flanking markers 1 221874007 221897841 1 - by flanking markers RRID:RGD_152999000 152999001 LE-Fxn em1Fara-/+ Exon 4 of the rat Fxn gene was targeted for homologous recombination to introduce loxP sites using CRISPR/Cas9 This strain has been deposited with RRRC. mutant Unknown Fxn em1Fara 152999004 1 227647092 227671081 1 - by flanking markers 1 249400435 249426597 1 - by flanking markers 1 242123975 242152834 1 - by flanking markers 1 221874007 221897841 1 - by flanking markers RRID:RGD_152999001 152999002 LE-Fxn em2Fara-/+/Rrrc Heterozygous KO of the Fxn gene obtained by targeting exon 4 with CRISPR/Cas9 system This strain has been deposited with RRRC Rat Resource and Research Center mutant Unknown Fxn em2Fara 152999006 1 227647092 227671081 1 - by flanking markers 1 249400435 249426597 1 - by flanking markers 1 242123975 242152834 1 - by flanking markers 1 221874007 221897841 1 - by flanking markers RRID:RRRC_00961 152999003 LE-Fxn em1Fara-/+/Rrrc Exon 4 of the rat Fxn gene was targeted for homologous recombination to introduce loxP sites using CRISPR/Cas9 Rat Resource and Research Center mutant Unknown Fxn em1Fara 152999004 1 227647092 227671081 1 - by flanking markers 1 249400435 249426597 1 - by flanking markers 1 242123975 242152834 1 - by flanking markers 1 221874007 221897841 1 - by flanking markers RRID:RRRC_00960 152999023 SD-Aif1tm(EGFP)Apps/Mmmc Applied StemCell, Inc (Milpitas, CA) was contracted to generate the Iba1-EGFP knock-in rat model using CRISPR/Cas9 technology in the Sprague Dawley rat strain. The donor construct inserted consisted of the EGFP coding sequence (minus the first ATG), followed by the 22 amino acid sequence of the porcine teschovirus-1 2A (P2A) self-cleaving peptide, and then the first exon of the rat Iba1 gene immediately downstream of the translational start site. Guide RNA with the following sequence: 5'- TACCCTGCAAATCCTTGCTCTGG-3' targeting the Iba1 gene just downstream of the translational start site were used. Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland 21201 mutant Unknown Aif1tm(EGFP)Apps 152999024 20 3714428 3716327 1 - by flanking markers 20 7234609 7240454 1 - by flanking markers 20 5161350 5167176 1 - by flanking markers 20 3646784 3652670 1 - by flanking markers RRID:RGD_152999023 153298963 Taiep/JosvRrrc These mutants were found in Sprague-Dawley rats at University of Puebla in 1989 and donated by John Svaren to RRRC now are maintained at RRRC Rat Resource and Research Center mutant Unknown RRID:RRRC_00963 153323320 MR/NRrrc Maudsely reactive Origin: as for MNR except selection was for high defecation response in the open field. To Harrington in 1965 at F25 and to NIH in 1964 at F18+ (Hansen et al 1982). Now is available at Rat Resource & Research Center Rat Resource and Research Center inbred Cryopreserved Embryo; Cryorecovery (as of 2022-08-15) RRID:RRRC_00173 153323324 FXLE12/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown Diabetes Obesity; Cancer RRID:RGD_153323324 153344518 FXLE15/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_153344518 153344519 LEXF1C/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown Diabetes Obesity; Cancer RRID:RGD_153344519 153344520 LEXF6B/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin. RGD HRDP, contact HRDP recombinant_inbred Unknown Diabetes Obesity; Cancer RRID:RGD_153344520 155260360 COP/HsdUwmRrrc Copenhagen Donated from Michael Gould/Jim Shull at University of Wisconsin Madison to Rat Resource & Research Center Rat Resource and Research Center inbred Unknown RRID:RRRC_00966 155260361 SD-Tg(Sycp1-Cas9-eGFP)SynblRrrc This project entailed generation of a novel rat strain in which a P2A-Cas9-T2A-EGFP coding sequence was inserted at the stop codon of the rat Sycp1 gene for co-expression of Cas9 and EGFP under the control of the Sycp1 regulatory elements. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 from RRRC. transgenic Cryopreserved Sperm (as of 2022-10-06) Genetics, Reproductive Biology, Gene Conversion, Active Genetics RRID:RGD_155260361 155260362 SD-Tg(Ddx4-Cas9)SynblRrrc rat strain designed to express Cas9 under the control of the rat Ddx4 (Vasa) regulatory elements while also retaining expression of Ddx4. The strategy entailed insertion of a P2A sequence followed by human-codon-optimized Cas9 coding sequences with nuclear localization signals near the C-terminus of the rat Ddx4 (Vasa) gene. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 RRRC transgenic Unknown Genetics, Reproductive Biology, Gene Conversion, Active Genetics RRID:RGD_155260362 155260363 SD-Tg(Cyp2e1-CYP2E1*-Cas9)SynblRrrc rat strain in which the rat Cyp2e1 gene is humanized by insertion of a human CYP2E1 minigene (CYP2E1*) insert at the native start codon. The insert also included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance of the modified allele when crossed to a rat expressing Cas9 in the germline. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 URL: URL: Doi:10.1101/2022.08.30.505951 RRRC transgenic Cryopreserved Sperm (as of 2022-10-06) Genetics, Reproductive Biology, Gene Conversion, Active Genetics, Drug Metabolism, Cyp450 RRID:RGD_155260363 155260364 SD-Tg(Cyp3a23-3a1-Cyp3A4*-Cas9)SynblRrrc rat strain in which the rat Cyp3a1 gene (Cyp3a23-3a1, RGD:628626) was inactivated by insertion of a human CYP3A4 minigene (Cyp3A4*) and the linked rat Cyp3a2 locus was simultaneously mutated by CRISPR-mediated indel introduction. Strain contains Indel 8 at the Rat 3A2 locus (55 kb away), The CYP3A4 minigene included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance. Strain contains and Active Genetic cassette which encodes a gRNA targeting the Rat 3A1 and 3A2 translation initiation site. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 URL: URL: Doi:10.1101/2022.08.30.505951 RRRC transgenic Cryopreserved Sperm (as of 2022-10-06) Genetics, Reproductive Biology, Gene Conversion, Active Genetics, Drug Metabolism, Cyp450 RRID:RGD_155260364 155260365 SD-Tg(Sycp1-Cas9-eGFP)Synbl This project entailed generation of a novel rat strain in which a P2A-Cas9-T2A-EGFP coding sequence was inserted at the stop codon of the rat Sycp1 gene for co-expression of Cas9 and EGFP under the control of the Sycp1 regulatory elements. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 Created by Dr. Kurt Jarnagin at Synbal, Inc.San Diego, CA, USA. Donated to Rat Resource & Research Center transgenic Cryopreserved Sperm (as of 2022-10-06) Genetics, Reproductive Biology, Gene Conversion, Active Genetics RRID:RGD_155260365 155260366 SD-Tg(Ddx4-Cas9)Synbl rat strain designed to express Cas9 under the control of the rat Ddx4 (Vasa) regulatory elements while also retaining expression of Ddx4. The strategy entailed insertion of a P2A sequence followed by human-codon-optimized Cas9 coding sequences with nuclear localization signals near the C-terminus of the rat Ddx4 (Vasa) gene. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 Created by Dr. Kurt Jarnagin at Synbal, Inc.San Diego, CA, USA. Donated to Rat Resource & Research Center transgenic Unknown Genetics, Reproductive Biology, Gene Conversion, Active Genetics RRID:RGD_155260366 155260367 SD-Tg(Cyp2e1-CYP2E1*-Cas9)Synbl rat strain in which the rat Cyp2e1 gene is humanized by insertion of a human CYP2E1 minigene (CYP2E1*) insert at the native start codon. The insert also included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance of the modified allele when crossed to a rat expressing Cas9 in the germline. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 URL: URL: Doi:10.1101/2022.08.30.505951 Created by Dr. Kurt Jarnagin at Synbal, Inc.San Diego, CA, USA. Donated to Rat Resource & Research Center transgenic Cryopreserved Sperm (as of 2022-10-06) Genetics, Reproductive Biology, Gene Conversion, Active Genetics, Drug Metabolism, Cyp450 RRID:RGD_155260367 155260368 SD-Tg(Cyp3a23-3a1-Cyp3A4*-Cas9)Synb rat strain in which the rat Cyp3a1 gene (Cyp3a23-3a1, RGD:628626) was inactivated by insertion of a human CYP3A4 minigene (Cyp3A4*) and the linked rat Cyp3a2 locus was simultaneously mutated by CRISPR-mediated indel introduction. Strain contains Indel 8 at the Rat 3A2 locus (55 kb away), The CYP3A4 minigene included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance. Strain contains and Active Genetic cassette which encodes a gRNA targeting the Rat 3A1 and 3A2 translation initiation site. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 URL: URL: Doi:10.1101/2022.08.30.505951 Created by Dr. Kurt Jarnagin at Synbal, Inc.San Diego, CA, USA. Donated to Rat Resource & Research Center transgenic Cryopreserved Sperm (as of 2022-10-06) Genetics, Reproductive Biology, Gene Conversion, Active Genetics, Drug Metabolism, Cyp450 RRID:RGD_155260368 155269039 WI.WDB-ROSA26tm1(H2B-tdTomato)/Nips PCR products of the human H2BC11 (H2B-6), tdTomato, splice acceptor sequence, and IRES-Neor-SV40pA were inserted into the NheI site of prRosa26-1 with an in-fusion cloning kit. The final tdTomato-H2B-6 targeting vector was linearized by SalI digestion. The vector was introduced into WDB/Nips-ES1/Nips (RGD ID:10054010) embryonic stem cells by electroporation. Targeted ES cells were injected into Crlj:WI (RGD ID: 2312504) blastocysts to produce chimeric rats. The chimeric rats were crossed with Crlj:WI rats to produce heterozygous founder rats.These rat strains are being maintained by crossing the founder rats with Crlj:WI rats. Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN mutant Cryopreserved Embryo (as of 2022-10-11) RRID:RGD_155269039 155269040 F344-Tg(CAG-ACE2)057Bryd The human ACE2 gene was placed under control of the synthetic CAG promoter which allows ubiquitous expression of the gene. Based on droplet digital PCR analysis, the strain carries only 1 copy of the transgene. The integration site is unknown. These rats express the human ACE2 gene. The encoded protein is a functional receptor for the spike glycoprotein of several human coronaviruses including SARS-CoV-2, the causative agent of coronavirus disease-2019 (COVID-19). Deposited at Rat Resource and Research Center transgenic Live Animals (as of 2022-10-11) RRID:RRRC_00946 155269102 McwiWfsmAap:HS Heterogeneous stock This HS is maintained and distributed from Dr. Palmer's laboratory at UCSD. The origin of HS was from 25 breeding pairs obtained from Dr. Eva Redei, Northwestern University (Chicago) at 55 breeding generations; these animals exhibit 30% genome-wide heterozygosity which is maintained by using a rotational breeding strategy. The Wake Forest HS rats were derived from NMcwi:HS at the Medical College of Wisconsin and maintained at Wake Forest Baptist Medical Center starting in 2017. The colony from Wake Forest was sent to Dr. Palmer's laboratory at University of California San Diego Department of Psychiatry. Dr. Abraham Palmer laboratory at UCSD outbred Unknown RRID:RGD_155269102 155598601 SD-Bmal1em1Mcwi CRISPR/Cas9 system was used to introduce a 58-base pair deletion in exon 6 in the rat Bmal1 gene of Crl:SD embryos. The deletion caused a premature stop codon in exon 6 resulting in a severe truncation of the Bmal1 protein. MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu mutant Unknown Bmal1em1Mcwi 155598603 1 171062181 171162426 1 - by flanking markers 1 185007527 185105413 1 - by flanking markers 1 178039002 178137469 1 - by flanking markers 1 167331756 167430235 1 - by flanking markers RRID:RGD_155598601 155630631 CD-Ctnsem2Vjupk The mutant rat was produced by injecting Crl:CD(SD) zygotes with gRNA +Cas9 ribonucleoprotein complex targeting exon 3 of rat Ctns. The founder of this strain possessed a 2-bp insertion which results in frameshift and pre-mature stop truncated protein. Vernon Jansen Unit, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand mutant Unknown Ctnsem2Vjupk 155630632 10 60060254 60075352 1 - by flanking markers 10 59488895 59503993 1 - by flanking markers 10 59749250 59772475 1 - by flanking markers 10 57801551 57817213 1 - by flanking markers RRID:RGD_155630631 155630633 CD-Ctnsem3Vjupk The mutant rat was produced by injecting Crl:CD(SD) zygotes with gRNA +Cas9 ribonucleoprotein complex targeting exon 3 of rat Ctns. The founder of this strain possessed a 8-bp insertion which results in frameshift and pre-mature stop truncated protein. Vernon Jansen Unit, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand mutant Unknown Ctnsem3Vjupk 155630634 10 60060254 60075352 1 - by flanking markers 10 59488895 59503993 1 - by flanking markers 10 59749250 59772475 1 - by flanking markers 10 57801551 57817213 1 - by flanking markers RRID:RGD_155630633 155630635 CD-Ctnsem4Vjupk The mutant rat was produced by injecting Crl:CD(SD) zygotes with gRNA +Cas9 ribonucleoprotein complex targeting exon 3 of rat Ctns. The founder of this strain possessed a 7-bp deletion which results in frameshift and pre-mature stop truncated protein. Vernon Jansen Unit, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand mutant Unknown Ctnsem4Vjupk 155630636 10 60060254 60075352 1 - by flanking markers 10 59488895 59503993 1 - by flanking markers 10 59749250 59772475 1 - by flanking markers 10 57801551 57817213 1 - by flanking markers RRID:RGD_155630635 155631259 Taiep These mutants were found in Sprague-Dawley rats at University of Puebla in 1989. A spontaneous neurological mutation was detected in a colony of Sprague Dawley rats. The animals developed a progressive neurological syndrome characterized by tremor (which appeared at the age of 1 month), ataxia (at 4 months), immobility episodes (after 5-6 months), audiogenic seizures and hindlimb paralysis (after 10 months). Cross breeding experiments indicate that this is an autosomal recessive mutation, The rat line was named taiep (tremor, ataxia, tonic immobility episodes, epilepsy and paralysis) rats. Departamento de Ciencias Fisiologicas, Universidad Autonoma de Puebla, Mexico. mutant Unknown RRID:RGD_155631259 155631261 SD-Brca1em1Kyo CRISPR/Cas9 system was used to generate this mutant; sgRNA+Cas9 targeting exon 4 of rat Brca1was injected to fertilized eggs of Jcl:SD rats (Clea Japan). The founder animal carried c.188T>A (p.L63X) was mated to closed-colony Jcl:SD rats. Kyoto University Institute of Laboratory Animals Graduate School of Medicine Yoshida Konoe-cho, Skyo-ku, Kyoto 606-8501 JAPAN mutant Unknown Brca1em1Kyo 155631262 10 90513630 90572676 1 - by flanking markers 10 89192653 89252760 1 - by flanking markers 10 89394821 89455093 1 - by flanking markers 10 86417441 86477762 1 - by flanking markers RRID:RGD_155631261 155631278 SD-Flnaem1Ang This mutant strain was generated by electroporating rat zygotes with CRISPRs/Cas9 system targeting exon12 of rat Flna into Crl:SD embryo. This mutant strain carries P637Q knock in the gene. The Transgenic Rats and ImmunoPhenomic (TRIP) facility in Nantes (France). mutant Unknown Flnaem1Ang 155631280 X 160362334 160385626 1 - by flanking markers 1 152200936 152227391 1 - by flanking markers X 156460785 156487245 1 - by flanking markers X 152007758 152034266 1 - by flanking markers RRID:RGD_155631278 155631285 SD-Tg(MECP2 )Chnsr PAC671D9 (AF031078) DNA containing all the exons of human MECP2 was injected to SD embryos to generate MECP2 duplication rat. transgenic Unknown RRID:RGD_155631285 155631289 SD-Pde6bem1Cgen This mutant strain was generated by microinjecting CRISPRs/Cas9 system targeting rat Pde6b. Pde6b knock out rat was successfully created. Cyagen Biosciences Inc, Santa Clara, CA, USA mutant Unknown Pde6bem1Cgen 155631290 14 1871037 1914170 1 - by flanking markers 14 2327104 2370811 1 - by flanking markers 14 2328690 2371913 1 - by flanking markers 14 1323310 1366450 1 - by flanking markers RRID:RGD_155631289 155631293 SD-Pde3aem1Bdr The rat mutant was generated by pronuclear microinjection of Sprague-Dawley rat zygotes with a mixture of Cas9/Cas9 system to target the region in the rat Pde3a gene homologous to the human T445N mutation. The rat model exhibits a 9-bp deletion within the conserved 15-bp regulatory region that leads to the loss of 3 amino acids (aa 441-443 analogous to human PDE3A aa 444-446). Max-Delbr'ck-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany mutant Unknown Pde3aem1Bdr 155631294 4 178658896 178930417 1 - by flanking markers 4 239659270 239921900 1 - by flanking markers 4 175431904 175703844 1 - by flanking markers 4 174172804 174443944 1 - by flanking markers RRID:RGD_155631293 155631295 SD-Pde3aem2Bdr The rat mutant was generated by pronuclear microinjection of Sprague-Dawley rat zygotes with a mixture of Cas9/Cas9 system to target the region in the rat Pde3a gene homologous to the human T445N mutation. The rat model exhibits a 20-bp deletion within the conserved 15-bp regulatory region that leads to n a frameshift and thus in a truncated and functionally deleted protein (functional DEL). Max-Delbr'ck-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany mutant Unknown Pde3aem2Bdr 155631296 4 178658896 178930417 1 - by flanking markers 4 239659270 239921900 1 - by flanking markers 4 175431904 175703844 1 - by flanking markers 4 174172804 174443944 1 - by flanking markers RRID:RGD_155631295 155631298 SD-Pde3aem3Bdr The rat mutant was generated by pronuclear microinjection of Sprague-Dawley rat zygotes with a mixture of Cas9/Cas9 system to target the catalytic domain in the rat Pde3a gene. The model has a carriesa CGT to TGD missense mutation and results in R862C substitutions in the protein Max-Delbr'ck-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany mutant Unknown Pde3aem3Bdr 155631299 4 178658896 178930417 1 - by flanking markers 4 239659270 239921900 1 - by flanking markers 4 175431904 175703844 1 - by flanking markers 4 174172804 174443944 1 - by flanking markers RRID:RGD_155631298 155641233 SD-Tg(Rho*P23H)1Lav This transgenic strain carries a copy of mouse Rhodopsin gene with a proline to histidine substitution at codon 23 (c.68C>A). Retinal Degeneration Rat Model Resource ,Rat Resource and Research Center transgenic Unknown RRID:RGD_155641233 155641235 WMI/Eer WKY most immobile 3 pairs of WKY males and females with highest immobility and lowest climbing scores in the forced swim test were mated. Dept. of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Rat Resource and Research Center inbred Unknown RRID:RRRC_00973 155641237 WLI/Eer WKY least immobile 3 pairs of WKY males and females with lowest immobility and highest climbing scores in the forced swim test were mated. Dept. of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Now deposited at Rat Resource and Research Center inbred Unknown RRID:RRRC_00967 155641239 SS.SR-(rs65785750-rs13452155)/OpazRrrc Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts. Now deposited at Rat Resource and Research Center congenic Cryopreserved Sperm; Cryorecovery (as of 2022-11-03) RRID:RRRC_00612 155641240 SS.SR-(rs65785750-rs106808193)/OpazRrrc Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts. Now deposit at Rat Resource and Research Center congenic Cryopreserved Sperm (as of 2022-11-03) 5 106408365 141744732 1 - by flanking markers 5 109436629 143913027 1 - by flanking markers 5 105452223 140120264 1 - by flanking markers RRID:RRRC_00613 155641241 SS.SR-(rs105019230-D17Rat44)/OpazRrrc Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains. Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts. Now deposited at Rat Resource and Research Center. congenic Cryopreserved Sperm (as of 2022-11-03) 17 63080042 81612488 1 - by flanking markers 17 55371177 75653670 1 - by flanking markers 17 57343133 73981731 1 - by flanking markers 17 70156777 70156904 1 - by flanking markers RRID:RRRC_00616 155641245 SD-Tg(Oprm1-icre)1Ottc Targeted knock-in adding a T2A-iCre to the Oprm1 (mu opioid receptor) in this cre recombinase reporter SD rat This rat was produced by Optogenetics and Transgenic Technology Core and now cryopreserved at RRRC. transgenic Unknown RRID:RGD_155641245 155641246 F344-Tg(Cx3cr1-cre/ERT2)3OttcRrrc The transgene of LE-Tg(Cx3cr1-cre)3Ottc (RGD: 13441557) was crossed onto Fischer344 background by backcrossing the hybrid to Fischer344 and select for the presence of transgene. The donor LE transgenic was generated by microinjection of LE embyos with a BAC DNA containing the Cx3cr1-cre/ERT2 transgene which is composed of cre/ERT2 recombinase gene driven by the rat genomic Cx3cr1promoter. This strain is now deposited at Rat Resource and Research Center transgenic Unknown RRID:RGD_155641246 155641247 F344.LE-ROSA26 em1(LTR-nLuc)Ottc/Rrrc The mutated ROSA26 locus of LE-(ROSA)26 em1(LTR-nLuc)Ottc (RGD:13208223) was crossed onto Fischer344 background by backcrossing the hybrid to Fischer344 and select for the presence of mutated locus. The LE donor is CRISPR/Case9 knock-in strain that has cre recombinase-dependent expression of nanoluciferase under the control of HIV LTR promoter inserted to the rat ROSA26 locus. now deposited at Rat Resource and Research Center mutant Unknown RRID:RRRC_00926 155641248 SD-ROSA26em1(LTR-nLuc)Ottc/Rrrc The CRISPR/Case9 knock-in rats have cre recombinase-dependent expression of nanoluciferase under the control of HIV LTR promoter inserted to the rat ROSA26 locus. This strain was created by Optogenetics and Transgenic Technology Core and now deposited at Rat Resource and Research Center mutant Unknown RRID:RRRC_00925 155641251 F344-Tg(CAG-ACE2)057BrydRrrc The human ACE2 gene was placed under control of the synthetic CAG promoter which allows ubiquitous expression of the gene. Based on droplet digital PCR analysis, the strain carries only 1 copy of the transgene. The integration site is unknown. These rats express the human ACE2 gene. The encoded protein is a functional receptor for the spike glycoprotein of several human coronaviruses including SARS-CoV-2, the causative agent of coronavirus disease-2019 (COVID-19). Rat Resource and Research Center transgenic Live Animals (as of 2022-11-04) RRID:RRRC_00946 155663364 SD-Del(Yp)1Mcwi CRISPR guide RNAs flanking Sry4a and Sry1 (Sry) on the Y-chromosome were injected into Crl:SD strain embryos. Chromosomal deletions have not been explicitly defined. Medical College of Wisconsin mutant Live Animals (as of 2022-11-11) RRID:RGD_155663364 155663365 CD-Tg(RNECO-180E22)208Arno This transgenic model line 208 was made by injecting bacterial artificial chromosome (BAC) RNECO-180E22, into Crl:CD(SD) strain embryos. The BAC clone RNECO-180E22, a kind gift of Helen Skaletsky, is derived from Rattus norvegicus strain SHR chromosome Y. Art Arnold laboratory, University of California Los Angeles transgenic Unknown RRID:RGD_155663365 155663366 CD-Tg(RNECO-180E22)424Arno This transgenic model line 424 was made by injecting bacterial artificial chromosome (BAC) RNECO-180E22, into Crl:CD(SD) strain embryos. The BAC clone RNECO-180E22, a kind gift of Helen Skaletsky, is derived from Rattus norvegicus strain SHR chromosome Y. Art Arnold laboratory, University of California Los Angeles transgenic Unknown RRID:RGD_155663366 155663367 CD-Tg(RNECO-180E22)733Arno This transgenic model line 733 was made by injecting bacterial artificial chromosome (BAC) RNECO-180E22, into Crl:CD(SD) strain embryos. The BAC clone RNECO-180E22, a kind gift of Helen Skaletsky, is derived from Rattus norvegicus strain SHR chromosome Y. Art Arnold laboratory, University of California Los Angeles transgenic Unknown RRID:RGD_155663367 155663368 CD-Tg(RNECO-180E22)737Arno This transgenic model line 737 was made by injecting bacterial artificial chromosome (BAC) RNECO-180E22, into Crl:CD(SD) strain embryos. The BAC clone RNECO-180E22, a kind gift of Helen Skaletsky, is derived from Rattus norvegicus strain SHR chromosome Y. Art Arnold laboratory, University of California Los Angeles transgenic Unknown RRID:RGD_155663368 155663559 SD-Gcgtm1(iCre)Lrina CRISPR/Cas9 technology was used to insert an IRES for iCre expression after the final coding sequence of exon 6 of the rat Gcg gene, before the 3' UTR. Strain has been deposited to RRRC(RRRC:00983, RGD:155663560) mutant Live Animals (as of 2022-11-28) Neuroscience, diabetes, metabolic syndrome, obesity, anxiety RRID:RGD_155663559 155663560 SD-Gcgtm1(iCre)Lrina/Rrrc CRISPR/Cas9 technology was used to insert an IRES for iCre expression after the final coding sequence of exon 6 of the rat Gcg gene, before the 3' UTR. This strain was created by Dr. Linda Rinaman PhD and now deposited at Rat Resource and Research Center mutant Unknown Neuroscience, diabetes, metabolic syndrome, obesity, anxiety RRID:RRRC_00983 155663675 LE-Tg(ChAT-cre)5.1Deis Cre gene was introduced immediately before the ATG of the mouse choline acetyltransferase (Chat) gene in BAC RP23-246B12. This strain is estimated to carry 6 copies of the transgene at the integration site. The strain is deposited to Rat Resource and Research Center transgenic Live Animals; Cryopreserved Sperm (as of 2022-12-05) RRID:RGD_155663675 155782877 SHRSP/NgskMeltw Imported from Kyoto University in 2010, now maintained at Molecular Embryological & DNA Methylation Lab at National Chung Hsing University, Taiwan. Department of Life Sciences in Molecular Embryological & DNA Methylation Lab at National Chung Hsing University, Taiwan inbred Live Animals (as of 2022-12-07) Chronic kidney disease; Hypertension; Proteinuria; Stroke RRID:RGD_155782877 155782879 SS-Chr3BN.SS-(D3Rat26-D3Mgh30)/Mcwi SS/JrHsdMcwi were crossed with SS-3BN/Mcwi, rats from F1 were intercrossed and genotyped to select the congenic strain carrying introgressed chromosome 3 from SS to BN. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown 3 90573349 153262477 1 - by flanking markers 3 101798743 164637442 1 - by flanking markers 3 95176716 158417703 1 - by flanking markers 3 91609794 151080115 1 - by flanking markers RRID:RGD_155782879 155782880 SS-Chr 3BN.SS-(D3Arb3-D3Rat93)( D3Rat78-D3Rat1)/Mcwi SS/JrHsdMcwi were crossed with SS-3BN/Mcwi, rats from F1 were intercrossed and genotyped to select the congenic strain carrying introgressed chromosome 3 from SS to BN. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown 3 35797577 147990731 1 - by flanking markers 3 44863125 158307423 1 - by flanking markers 3 39773247 153412619 1 - by flanking markers 3 38710365 145956249 1 - by flanking markers RRID:RGD_155782880 155782881 SS-Chr3BN.SS-(D3Rat222-D3Rat218)/Mcwi SS/JrHsdMcwi were crossed with SS-3BN/Mcwi, rats from F1 were intercrossed and genotyped to select the congenic strain carrying introgressed chromosome 3 from SS to BN. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown 3 77727907 126079458 1 - by flanking markers 3 88924451 137527624 1 - by flanking markers 3 82222060 131051652 1 - by flanking markers 3 79285268 125293758 1 - by flanking markers RRID:RGD_155782881 155782885 SS-Chr3BN.SS-(D3Rat36-D3Rat156)/Mcwi SS/JrHsdMcwi were crossed with SS-3BN/Mcwi, rats from F1 were intercrossed and genotyped to select the congenic strain carrying introgressed chromosome 3 from SS to BN. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown 3 78808731 124269028 1 - by flanking markers 3 89999731 135651688 1 - by flanking markers 3 83300114 129166212 1 - by flanking markers 3 80367329 123513386 1 - by flanking markers RRID:RGD_155782885 155782909 SS-Chr3BN.SS-(D3Arb22 - D3Mgh30)/Mcwi SS/JrHsdMcwi were crossed with SS-3BN/Mcwi, rats from F1 were intercrossed and genotyped to select the congenic strain carrying introgressed chromosome 3 from SS to BN. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown 3 136541408 153262477 1 - by flanking markers 3 148587087 164637442 1 - by flanking markers 3 142174160 158417703 1 - by flanking markers 3 135287266 151080115 1 - by flanking markers RRID:RGD_155782909 155782910 SS-Chr3BN.SS-(D3Rat154 - D3Mgh30)/Mcwi SS/JrHsdMcwi were crossed with SS-3BN/Mcwi, rats from F1 were intercrossed and genotyped to select the congenic strain carrying introgressed chromosome 3 from SS to BN. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown 3 125060606 153262477 1 - by flanking markers 3 136438243 164637442 1 - by flanking markers 3 129958906 158417703 1 - by flanking markers 3 124286544 151080115 1 - by flanking markers RRID:RGD_155782910 155782911 SS-Chr3BN.SS-(D3Rat26 - D3Rat14)/Mcwi SS/JrHsdMcwi were crossed with SS-3BN/Mcwi, rats from F1 were intercrossed and genotyped to select the congenic strain carrying introgressed chromosome 3 from SS to BN. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown 3 90573349 127698688 1 - by flanking markers 3 101798743 139030095 1 - by flanking markers 3 95176716 132567457 1 - by flanking markers 3 91609794 126854898 1 - by flanking markers RRID:RGD_155782911 155782912 SS-Chr3BN.SS-(D3Rat26 - D3Rat5)/Mcwi SS/JrHsdMcwi were crossed with SS-3BN/Mcwi, rats from F1 were intercrossed and genotyped to select the congenic strain carrying introgressed chromosome 3 from SS to BN. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown 3 90573349 148643323 1 - by flanking markers 3 101798743 161185522 1 - by flanking markers 3 95176716 154416795 1 - by flanking markers 3 91609794 146592883 1 - by flanking markers RRID:RGD_155782912 155782913 SS-Chr3BN.SS-(D3Rat12 - D3Mgh30)/Mcwi SS/JrHsdMcwi were crossed with SS-3BN/Mcwi, rats from F1 were intercrossed and genotyped to select the congenic strain carrying introgressed chromosome 3 from SS to BN. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown 3 127988419 153262477 1 - by flanking markers 3 139333901 164637442 1 - by flanking markers 3 132875075 158417703 1 - by flanking markers 3 127162703 151080115 1 - by flanking markers RRID:RGD_155782913 155782914 SS-Chr3BN.SS-(D3Rat217- D3Mgh30)/Mcwi SS/JrHsdMcwi were crossed with SS-3BN/Mcwi, rats from F1 were intercrossed and genotyped to select the congenic strain carrying introgressed chromosome 3 from SS to BN. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown 3 134491977 153262477 1 - by flanking markers 3 146499815 164637442 1 - by flanking markers 3 140077066 158417703 1 - by flanking markers 3 133293002 151080115 1 - by flanking markers RRID:RGD_155782914 155782915 SS-Chr3BN.SS-(D3Rat26 - D3Rat217)/Mcwi SS/JrHsdMcwi were crossed with SS-3BN/Mcwi, rats from F1 were intercrossed and genotyped to select the congenic strain carrying introgressed chromosome 3 from SS to BN. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown 3 90573349 134492553 1 - by flanking markers 3 101798743 146499996 1 - by flanking markers 3 95176716 140077247 1 - by flanking markers 3 91609794 133293184 1 - by flanking markers RRID:RGD_155782915 155791425 SS-Chr 3BN-Il2rgem1Mcwi/Mcwi The IL2Rg gene was targeted in the SS/JrHsdMcwi rat by TALEN injection into single-cell rat embryos. Once established, a homozygous (RGD:12790632) female rat from the SSIL2Rg line was intercrossed with a homozygous SS.BN3 (RGD:1358154) male to yield heterozygous SS.BN3IL2Rg offspring (F1), followed by brother-sister mating to yield homozygous SS. BN3IL2Rg offspring by the F3 generation. This strain is Immunodeficient Ilrg (X-SCID) mutant consomic line. Medical College of Wisconsin mutant Unknown RRID:RGD_155791425 155791431 SS-Chr 3BN.SS-(D3Arb3-D3Rat93)( D3Rat78-D3Rat1)-Il2rgem1/Mcwi Immunodeficient congenic line developed by intercross of SS-Chr 3BN.SS-(D3Arb3-D3Rat93)( D3Rat78-D3Rat1)/Mcwi (RGD:155782880) withSS-Il2rgem1Mcwi (RGD:12790632) to breed the Il2rg (X-SCID) mutation into this background. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown RRID:RGD_155791431 155791432 SS-Chr 3BN.SS-(D3Rat26-D3Mgh30)-Il2rgem1/Mcwi Immunodeficient congenic line developed by intercross of SS-Chr3BN.SS-(D3Rat26-D3Mgh30)/Mcwi(RGD:155782879) withSS-Il2rgem1Mcwi (RGD:12790632) to breed the Il2rg (X-SCID) mutation into this background. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown RRID:RGD_155791432 155791433 SS-Chr 3BN.SS-(D3Rat222-D3Rat218)-Il2rgem1/Mcwi Immunodeficient congenic line developed by intercross of SS-Chr3BN.SS-(D3Rat222-D3Rat218)/Mcwi(RGD:155782881) withSS-Il2rgem1Mcwi (RGD:12790632) to breed the Il2rg (X-SCID) mutation into this background. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown RRID:RGD_155791433 155791434 SS-Chr 3BN.SS-(D3Rat222-D3Got42)-Il2rgem1/Mcwi Immunodeficient subcongenic line developed by intercross SS-Chr 3BN.SS-(D3Rat222-D3Rat218)-Il2rgem1Mcwi/Mcwi (RGD:155791433) heterozygous congenic, Il2rg null mutant (X-SCID) lines. . This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown RRID:RGD_155791434 155791435 SS-Chr 3BN.SS-(D3Rat222-D3Mco33)-Il2rgem1/Mcwi Immunodeficient subcongenic line developed by intercross SS-Chr 3BN.SS-(D3Rat222-D3Rat218)-Il2rgem1Mcwi/Mcwi (RGD:155791433) heterozygous congenic, Il2rg null mutant (X-SCID) lines. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown RRID:RGD_155791435 155791436 SS-Chr 3BN.SS-(D3Rat26-D3Rat218)-Il2rgem1/Mcwi Immunodeficient subcongenic line developed by intercross SS-Chr 3BN.SS-(D3Rat222-D3Rat218)-Il2rgem1Mcwi/Mcwi (RGD:155791433) heterozygous congenic, Il2rg null mutant (X-SCID) lines. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown RRID:RGD_155791436 155791437 SS-Chr 3BN.SS-(D3Rat160-D3Rat218)-Il2rgem1/Mcwi Immunodeficient subcongenic line developed by intercross SS-Chr 3BN.SS-(D3Rat222-D3Rat218)-Il2rgem1Mcwi/Mcwi (RGD:155791433) heterozygous congenic, Il2rg null mutant (X-SCID) lines. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. congenic Unknown RRID:RGD_155791437 155791438 SS-Chr 3BN.SS-(D3Rat164-D3Rat218)-Il2rgem1/Mcwi Immunodeficient subcongenic line developed by intercross SS-Chr 3BN.SS-(D3Rat222-D3Rat218)-Il2rgem1Mcwi/Mcwi (RGD:155791433) heterozygous congenic, Il2rg null mutant (X-SCID) lines. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. mutant Unknown RRID:RGD_155791438 155791439 SS-Chr 3BN.SS-(D3Mgh13-D3Rat218)-Il2rgem1/Mcwi Immunodeficient subcongenic line developed by intercross SS-Chr 3BN.SS-(D3Rat222-D3Rat218)-Il2rgem1Mcwi/Mcwi (RGD:155791433) heterozygous congenic, Il2rg null mutant (X-SCID) lines. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. mutant Unknown RRID:RGD_155791439 155791440 SS-Chr 3BN.SS-(D3Rat 86 to D3Rat218)-Il2rgem1/Mcwi Immunodeficient subcongenic line developed by intercross SS-Chr 3BN.SS-(D3Rat222-D3Rat218)-Il2rgem1Mcwi/Mcwi (RGD:155791433) heterozygous congenic, Il2rg null mutant (X-SCID) lines. This strain was submitted by Dr. Amit Joshi Medical College of Wisconsin. Contact MCW rat distribution at mcwcustomrats@mcw.edu for availability. mutant Unknown RRID:RGD_155791440 155791645 BN/NOlaHsd In 1980, from National Institutes of Health, Bethesda, USA (BN/SsN, RGD:61115) to OLAC (now Envigo). Harlan Sprague Dawley, Inc., Indianapolis, IN inbred Unknown RRID:RGD_155791645 155804258 BN/Rij inbred Brown Norway (BN) rat strain produced in the Rijswijk colony. inbred Unknown RRID:RGD_155804258 155888488 MWF/SimwMcwi A colony of inbred Munich Wistar Fromter (MWF) rats maintained at the Medical College of Wisconsin since 2014, more than 20 breeding generations. Imported from a colony at Indiana University maintained more than 20 years; originally obtained from Roland Blatz at the University of California, San Diego Medical College of Wisconsin inbred Live Animals (as of 2023-02-07) RRID:RGD_155888488 155888489 MWF/Simw A colony of Munich Wistar Fromter (MWF) rats maintained at Indiana University over 20 years, originally obtained from Roland Blatz at the University of California, San Diego Indiana University inbred Live Animals (as of 2023-02-07) RRID:RGD_155888489 155900755 SD-Chrna6em1Slot Using CRISPR/Cas9 genomic engineering in rats via homologous end-joining in fertilized embryos, we have knocked'in a humanized CHRNA6 3'UTR in place of the natural CHRNA6 3'UTR of the Sprague Dawley rat line. This new genetically modified CHRNA6C123G humanized rat line carries a homozygous GG nucleotide modification at position 123 within the CHRNA6 gene 3'UTR. The laboratory has deposited these strains with the RRRC. mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2023-02-09) Drug Addiction, Nicotine/Tobacco Addiction Chrna6em1Slot 155900756 16 69012201 69018901 1 - by flanking markers 16 68486608 68493308 1 - by flanking markers 16 68860018 68866718 1 - by flanking markers 16 64697741 64704441 1 - by flanking markers RRID:RRRC_00984 155900757 SD-Chrna6em2Slot Using CRISPR/Cas9 genomic engineering in rats via homologous end-joining in fertilized embryos, we have knocked'in a humanized CHRNA6 3'UTR in place of the natural CHRNA6 3'UTR of the Sprague Dawley rat line. This new genetically modified CHRNA6C123G humanized rat line carries a homozygous CC nucleotide modification at position 123 within the CHRNA6 gene 3'UTR. The laboratory has deposited these strains with the RRRC. mutant Cryopreserved Embryo; Cryopreserved Sperm (as of 2023-02-09) Drug Addiction, Nicotine/Tobacco Addiction Chrna6em2Slot 155900759 16 69012201 69018901 1 - by flanking markers 16 68486608 68493308 1 - by flanking markers 16 68860018 68866718 1 - by flanking markers 16 64697741 64704441 1 - by flanking markers RRID:RRRC_00985 156212871 HSRA/Ummc heterogeneous stock-derived renal agenesis rat An inbred strain derived from the Heterogeneous Stock by selective inbreeding more than 20 generations for spontaneous renal agenesis. Michael Garrett, University of Mississippi Medical Center inbred Live Animals (as of 2023-02-14) Renal agenesis, CAKUT, altered neprhogenesis RRID:RGD_156212871 156340304 MWF/HsdMcwi Munich Wistar Fromter These are re-derived rats of from substrain of Munich Wistar stock, inbred by Harlan Sprague Dawley and now maintained at Medical College of Wisconsin RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu inbred Unknown RRID:RGD_156340304 156354230 PVG/SeacMcwi Piebald Virol Glaxo These are re-derived rats of from Seac Yoshitomi, LTD., Fukuoka, Japan. and maintained at Medical College of Wisconsin. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu inbred Unknown Immunology RRID:RGD_156354230 156362762 RCS/LavRrrcMcwi royal college of surgeons rat These are re-derived rats of from RCS/LavRrrc and maintained at Medical College of Wisconsin. Originally developed before 1965 by Sidman from stock obtained from Sorsby of the Royal College of Surgeons, London. Then to University of California- San Francisco, School of Medicine, deposited to Rat Resource & Research Center. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu inbred Unknown RRID:RGD_156362762 156368567 BDIX/NemOdaMcwi These are re-derived rats of from BDIX/NemOda and maintained at Medical college of Wisconsin. This strain was maintained in Germany and was transferred to Japan by Dr. Tanaka of Aichi Cancer Center. Thereafter, this strain was transferred to Research Institute of Environmental Medicine, Nagoya University in 1973 and to Department of Agricultural, Nagoya University in 1992. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu inbred Unknown Cancer RRID:RGD_156368567 156403001 BUF/MnaMcwi These are re-derived rats of from BUF/Mna and maintained at Medical College of Wisconsin. BUF strain originated from Heston 1946 from Buffalo stock of H. Morris. To NIH in 1950 at F10. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu inbred Unknown Cancer; Urology RRID:RGD_156403001 156406412 HTX/KyoMcwi hydrocephalus texas These are re-derived rats of from HTX/Kyo and maintained at Medical College of Wisconsin.1981 by Kohn from institutional albino rats of unknown origin at University of Texas. From Juntendo University to Kyoto University in 1992. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu inbred Unknown Neurobiology RRID:RGD_156406412 156420138 MR/HarMcwi Maudsely reactive These are re-derived rats of MR/Har now maintained at Medical College of Wisconsin. This strain has been selected for high open-field defecation (a test of emotional reactivity). The underlying genetic basis for this phenotype is not known. Originally selected by Broadhurst in 1954 for high open-field defacation (OFD) response in an open field. By Broadhurst to Harrington at the University of Northern Iowa at generation 25 in 1965. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu inbred Unknown RRID:RGD_156420138 156420139 MNS/NMcwi Milan normotensive strain These are re-derived rats of MNS/N now maintained at Medical College of Wisconsin. Origin: Wistar rats with brother x sister mating and selection for low systolic blood pressure as a normotensive control for MHS. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu inbred Unknown RRID:RGD_156420139 156420144 HXB1/IpcvMcwi Embryo-rederived from breeder stock HXB1/Ipcv provided by Pravenec and Kren from the Prague colonies, maintained at Medical college of Wisconsin. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu recombinant_inbred Unknown RRID:RGD_156420144 156420145 HXB7/IpcvMcwi Embryo-rederived from breeder stock HXB7/Ipcv provided by Pravenec and Kren from the Prague colonies, maintained at Medical college of Wisconsin. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu recombinant_inbred Unknown RRID:RGD_156420145 156420146 HXB13/IpcvMcwi Embryo-rederived from breeder stock HXB13/Ipcv provided by Pravenec and Kren from the Prague colonies, maintained at Medical college of Wisconsin. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu recombinant_inbred Unknown RRID:RGD_156420146 156420147 HXB17/IpcvMcwi Embryo-rederived from breeder stock provided by Pravenec and Kren from the Prague colonies, maintained at Medical college of Wisconsin. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu recombinant_inbred Unknown RRID:RGD_156420147 156420148 HXB18/IpcvMcwi Embryo-rederived from breeder stock HXB18/Ipcv provided by Pravenec and Kren from the Prague colonies, maintained at Medical college of Wisconsin. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu recombinant_inbred Unknown RRID:RGD_156420148 156420149 HXB23/IpcvMcwi Embryo-rederived from breeder stock HXB23/Ipcv provided by Pravenec and Kren from the Prague colonies, maintained at Medical college of Wisconsin. RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu recombinant_inbred Unknown RRID:RGD_156420149 156420150 BXH6/CubMcwi Embryo-rederived from breeder stock BXH6/Cub provided by Dr. Kren from Charles University, Department of Biology, Prague, Czech Republic, maintained at Medical College of Wisconsin RGD HRDP, contact Hybrid Rat Diversity Panel at HRDP@mcw.edu recombinant_inbred Unknown RRID:RGD_156420150 156420151 ZDF-Leprfa/+/Crl This is the control model for the ZDF-Leprfa/Crl. Charles River Laboratories coisogenic Unknown RRID:RGD_156420151 156420152 Mlac:WR Wistar rats This outbred Wistar was maintained at National Laboratory Animal Center (NLAC), Thailand. All animals were housed at the Chulalongkorn University Laboratory Animal Center (CULAC) . National Laboratory Animal Center, Mahidol University Thailand outbred Unknown RRID:RGD_156420152 156420153 Mlac:SD Sprague Dawley rats This outbred Sprague Dawley was maintained at National Laboratory Animal Center (NLAC), Thailand. All animals were housed at the Chulalongkorn University Laboratory Animal Center (CULAC) . National Laboratory Animal Center, Mahidol University Thailand outbred Unknown RRID:RGD_156420153 156430076 LEXF1A/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430076 156430077 LEXF2A/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430077 156430078 LEXF2B/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430078 156430079 LEXF2C/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430079 156430080 LEXF3/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown Diabetes Obesity; Cancer RRID:RGD_156430080 156430081 LEXF4/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430081 156430082 LEXF5/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430082 156430083 LEXF7A/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430083 156430085 LEXF7B/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430085 156430086 LEXF7C/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430086 156430087 LEXF8A/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430087 156430089 LEXF8D/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430089 156430090 LEXF9/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430090 156430091 LEXF10B/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430091 156430092 LEXF10C/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430092 156430093 LEXF11/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430093 156430094 FXLE13/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430094 156430095 FXLE14/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430095 156430099 FXLE16/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430099 156430100 FXLE17/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430100 156430101 FXLE18/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430101 156430102 FXLE19/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430102 156430103 FXLE21/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430103 156430104 FXLE22/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430104 156430105 FXLE23/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430105 156430106 FXLE24/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430106 156430107 FXLE25/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430107 156430108 FXLE26/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/Stm. RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430108 156430109 FXLE20/StmMcwi This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. This substrain was maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430109 156430110 BXH12-1/CubMcwi Embryo-rederived from breeder stock BXH12-1/Cub provided by Dr. Kren from Charles University, Department of Biology, Prague, Czech Republic, maintained at Medical College of Wisconsin RGD HRDP, contact HRDP recombinant_inbred Unknown RRID:RGD_156430110 156430169 SD-Mecp2em1Sage/Hsd The MeCP2 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo. The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Mecp2 into Sprague Dawley embryos. This mutant rat has a knockout of the methyl CpG binding protein 2 (Mecp2). ENVIGO mutant Cryopreserved Embryo (as of 2023-02-22) Autism, Rett syndrome, Cognition RRID:RGD_156430169 156430327 FSL Flinders Sensitive Line Rat Flinders Sensitive Line Rat (FSL) was selectively bred from outbred Sprague Dawley for increased response an anticholinesterase agent. The FSL rat partially resembles depressed individuals with phenotypes of reduced appetite and psychomotor function but exhibits normal hedonic responses and cognitive function. Karolinska Institutet, Stockholm Sweden inbred Unknown RRID:RGD_156430327 156430328 FRL Flinders Resistant Line Rat Flinders Resistant Line Rat (FRL) was selectively bred from outbred Sprague Dawley for less response to an anticholinesterase agent than FSL. FRL is not more resistant to the anticholinesterase agent compared to other outbred rats. The FSL rat partially resembles depressed individuals with phenotypes of reduced appetite and psychomotor function but exhibits normal hedonic responses and cognitive function. Karolinska Institutet, Stockholm Sweden inbred Unknown RRID:RGD_156430328 156451369 HAD high-alcohol-drinking These high-alcohol-drinking rats were developed by selective breeding from the heterogeneous N/N (N:NIH) strain . 8 inbred rat strains were intercrossed for alcohol preference and consumption.Within-family selection and a rotational breeding design were employed to reduce inbreeding and to allow maintenance of non-inbred replicate lines Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana outbred Unknown RRID:RGD_156451369 156451370 LAD low-alcohol-drinking These low-alcohol-drinking were developed by selective breeding from the heterogeneous strain N:NIH (RGD:728185). 8 inbred rat strains were intercrossed for alcohol preference and consumption. Within-family selection and a rotational breeding design were employed to reduce inbreeding and to allow maintenance of non-inbred replicate lines. Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana outbred Unknown RRID:RGD_156451370 158013766 SD-Akt1em1Soar This Akt mutant strain was created in zygotes from Holtzman Sprague-Dawley. Guided RNAs targeting exon 4 (target sequence: GCCGTTTGAGTCCATCAGCC; nucleotides 356-375) and exon 7 (target sequence: TTGTCATGGAGTACGCCAAT; nucleotides 712-731) of the Akt1 gene (NM_033230.3) were injected to the embryos to create a1332-bp deletion from exon 4 to exon7, resulting a premature stop of the protein. Institute for Reproductive and Developmental Sciences, Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA. mutant Unknown Akt1em1Soar 158013767 6 137640482 137657552 1 - by flanking markers 6 146225955 146247008 1 - by flanking markers 6 137218398 137239970 1 - by flanking markers 6 131713716 131735319 1 - by flanking markers RRID:RGD_158013766 288084580 F344-Txn1m1Kyo age dependent mitochondrial cytopathy rat This mutation Phe54Leu is an autosomal dominant mutation that appeared in a stock of F344/NSlc rats that had been mutagenized with N-ethyl-N-nitrosourea (ENU). Rats heterozygous for Txn1 (Txn1 /+) exhibited running seizures only in its juvenile stage. The rat called Adem rat, exhibited age dependent mitochondrial cytopathy (Adem). The rats were backcrossed for more than ten generations on the F344/NSlc inbred background to ensure other mutations induced by ENU was reduced. The causative gene was identified as a missense substitution (c. 160 T > C, p. Phe54Leu) in exon 3 of Txn1. Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan mutant Unknown Neurobiology RRID:RGD_288084580 288084582 F344-Txn1 em1Kyo This CRISPR/Cas9 induced mutation Phe54Leu is induced in embryos of F344/NSlc. The genome editing system targeting exon 3 of Txn1 gene ( (c. 160 T > C) was delivered into embryos by electroporation. The two-cell stage embryos were transferred into the oviducts of pseudopregnant females. The rat called Txn1-F54L rat, replicates Adem rats (RGD:288084580) which carried Phe54Leu mutation in the same gene.These two strains exhibit similar phenotype. Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan mutant Unknown Neurobiology RRID:RGD_288084582 291492855 SD-Tg(Prp-DISC1)Uhg Transgenic Sprague Dawley rats were generated by injecting the linearized fragment of the CosSHa.tet vector containing the full-length, non-mutant human DISC1 as transgene with the polymorphisms F607 and C704, under the control of the Syrian hamster prion protein promoter, into pronuclei of Sprague Dawley rats. Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich-Heine University D�sseldorf, D�sseldorf, Germany transgenic Unknown RRID:RGD_291492855 329322880 SD-Mertkem1Cgen The gRNA to rat Mertk gene, and Cas9 mRNA were co-injected into fertilized rat eggs to generate targeted knockout offspring. F0 founder animals were identified by PCR followed by sequence analysis, which were bred to wildtype rat to test germline transmission and F1 animal generation. This strain was derived from founder 6# carrying a 13934 deletion which included exons 3 to 5. Cyagen Biosciences (Guangzhou) Inc.Building D, 3rd Floor, 3 Juquan Road, Science City, Guangzhou, 510663, China mutant Live Animals (as of 2023-04-24) RRID:RGD_329322880 329333019 SD-Spon2em1Holi This Spon2 knockout mutant was produced by injecting TALENs targeting exon 2 of rat Spon2 into Sprague Dawley embryos. Founder #4-1 (a1) carrying a 22-bp deletion was chosen to produce heterozygous and homozygous rats. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China mutant Unknown Spon2em1Holi 329333021 RRID:RGD_329333019 329812004 Ibd:WI Wistar rats The Wistar rats maintained at The Nencki Institute of Experimental Biology of the Polish Academy of Sciences, Warsaw, Poland outbred Unknown RRID:RGD_329812004